Nutrition Clinique et Metabolisme最新文献

{"title":"Molecular crosstalk between nutrition and osteosarcopenia in chronic liver disease: Pathophysiology and therapeutic prospects","authors":"Omer Qutaiba B. Allela ,&nbsp;Abdulkareem Shareef ,&nbsp;Hayder Naji Sameer ,&nbsp;Ahmed Yaseen ,&nbsp;Zainab H. Athab ,&nbsp;Mohaned Adil","doi":"10.1016/j.nupar.2025.09.002","DOIUrl":"10.1016/j.nupar.2025.09.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Osteosarcopenia, defined by the simultaneous loss of bone and muscle mass, is a growing complication in chronic liver disease (CLD) that worsens frailty, fracture risk, and clinical outcomes. However, its nutritional and molecular drivers remain poorly understood. This scoping review examines the prevalence and clinical impact of osteosarcopenia in CLD and explores underlying nutritional and metabolic pathways to identify modifiable dietary targets for prevention and treatment.</div></div><div><h3>Material and methods</h3><div>A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science up to May 2025. Twenty-six eligible studies were included: seven focused on prevalence and outcomes, and nineteen investigated nutrient-related mechanisms. Thematic synthesis was guided by PRISMA-ScR methodology.</div></div><div><h3>Results</h3><div>Osteosarcopenia affects up to 20% of individuals with CLD and is independently associated with increased frailty, fractures, and mortality. Pathophysiological drivers include amino acid depletion, vitamin D deficiency, bile acid-related malabsorption, and endocrine dysregulation (e.g., reduced IGF-1, elevated myostatin). Inflammatory and oxidative pathways mediated by TNF-α, IL-6, and NF-κB further promote musculoskeletal catabolism. Nutrients such as leucine, arginine, glutamine, vitamin D, omega-3 fatty acids, and gut-derived short-chain fatty acids modulate critical anabolic and anti-catabolic pathways, including the mTORC1, Wnt/β-catenin, SIRT1/PGC-1α, and Nrf2 pathways.</div></div><div><h3>Conclusion</h3><div>Osteosarcopenia in CLD is not merely a secondary consequence of malnutrition but a distinct, nutritionally modifiable syndrome driven by disrupted inter-organ crosstalk. Dietary interventions targeting gut-muscle-bone-liver axes could represent safe, scalable, and cost-effective strategies to mitigate musculoskeletal decline in CLD. Integrating nutrition into hepatology care is a critical priority to enhance patient resilience, independence, and survival.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 282-291"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of creatine supplementation on muscle protein synthesis in athletes: A review","authors":"Mohammad Ali Izadi,&nbsp;Farhad Daryanoosh","doi":"10.1016/j.nupar.2025.09.001","DOIUrl":"10.1016/j.nupar.2025.09.001","url":null,"abstract":"<div><div>Muscle mass is a key factor in the performance and health of athletes. Skeletal muscle mass is determined by the balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). One of the goals of strength athletes is to have more muscle mass through exercise, nutritional, and supplementation strategies. From a supplementation perspective, creatine supplementation, especially when combined with resistance training, is recognized as a strategy for increasing lean tissue mass and muscle strength. The mechanisms of action of creatine in skeletal muscle include increased energy availability, IGF-1 signaling, activation of the mTOR pathway, increased intracellular water, activation of satellite cells, reduced muscle damage, and improved recovery, which are discussed in this review. This article provides a comprehensive review of the current literature on creatine supplementation and its effects on MPS in athletes. We review the mechanisms through which creatine exerts its effects, its implications for different types of exercise training, and considerations for optimal dosing protocols.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 273-281"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint association of the triglyceride glucose and body roundness index with cardiovascular diseases among Chinese middle and old-aged adults with abnormal glucose metabolism: A nationwide prospective cohort study","authors":"Wangyang Bai ,&nbsp;Yi Ling ,&nbsp;Hangqi Chen ,&nbsp;Xiaofei Ye ,&nbsp;Jinfang Xu ,&nbsp;Xiaojing Guo ,&nbsp;Jia He","doi":"10.1016/j.nupar.2025.08.003","DOIUrl":"10.1016/j.nupar.2025.08.003","url":null,"abstract":"<div><h3>Objectives</h3><div>It remains unclear whether the combined use of the triglyceride glucose index (TyG) and body roundness index (BRI), specifically the triglyceride glucose-body roundness index (TyG-BRI), is associated with the incidence of cardiovascular diseases (CVD). This study aimed to investigate the joint association of the TyG and BRI with CVD among middle-aged and elderly adults with abnormal glucose metabolism.</div></div><div><h3>Material and methods</h3><div>This study obtained four national waves data from China Health and Retirement Longitudinal Study. Patients age ≥<!--> <!-->45 years with abnormal glucose metabolism were included. The primary outcome was incident CVD. Multivariable-adjusted Cox proportional hazards regression models were employed to assess the joint association of the TyG, BRI and the TyG-BRI with outcomes.</div></div><div><h3>Results</h3><div>A total of 4805 Chinese adults with abnormal glucose metabolism were enrolled in this study. In the follow-up, 899 participants (18.7%) experienced CVD events. Compared to the first quartile of the index, the fourth quartile of TyG-BRI was associated with increased risk for CVD by 53.8% (HR, 1.538 [95% CI, 1.249–1.893]). Mediation effects analyses revealed that high TyG index significantly mediated 4.545% (<em>P</em> <!-->=<!--> <!-->0.016) of the association between a high BRI and CVD incidence, while BRI simultaneously mediated 14.583% (<em>P</em> <!-->&lt;<!--> <!-->0.001) of the association between high TyG index and CVD.</div></div><div><h3>Conclusions</h3><div>TyG, BRI, and the combined TyG-BRI index are independently associated with increased risks of CVD among middle-aged and older adults with abnormal glucose metabolism in China. These indicators are easy to obtain and can be implemented in resource-limited primary hospitals to assist clinical practitioners in early screening and assessment of cardiovascular disease risk in patients with abnormal glucose metabolism.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 310-318"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145595039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canevas de structuration d’une unité transversale de nutrition institutionnelle","authors":"Frédéric V. Valla ,&nbsp;Cécile Betry ,&nbsp;Alexandra Aupetit ,&nbsp;Dorothée Bedock ,&nbsp;Cécile Bossu Estour ,&nbsp;Caroline Dendoncker ,&nbsp;Adam Jirka ,&nbsp;Johann Morizot ,&nbsp;Alexandre Morvan ,&nbsp;Dominique Soupart ,&nbsp;Bérénice Teulieres ,&nbsp;Sophie Vandendorpe ,&nbsp;Maggie Le Bourhis ,&nbsp;Francisca Joly","doi":"10.1016/j.nupar.2025.07.004","DOIUrl":"10.1016/j.nupar.2025.07.004","url":null,"abstract":"<div><div>In 2002, the French ministry of health encouraged the creation of organized and specialized healthcare professional teams dedicated to nutrition support within healthcare institutions. Since then, many institutions have implemented local nutrition support teams (NST), with locally defined objectives, scopes, missions and resources. However, only 17% of French and Belgian institutions have managed to do so and many others struggle to implement a local NST. A multidisciplinary group was set up, with 12 experts involved in a local NST, with the input of a hospital director and a health economist, to help design future local NST, through an NST Framework. Eleven questions were generated (NST scope of action, mission, institutional interaction and integration, composition, mandatory tools, rationale, health economic model, training, dietician and medical doctors’ collaboration, and resultant monitoring). Plans and strategies were conceived for each of the 11 questions, to facilitate local healthcare institutions to adapt this framework to their local context.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 251-259"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-carbohydrate diet-induced central obesity in gerbils: 20-hydroxyecdysone effects on adrenal zona fasciculata histology","authors":"Zineb Bellahreche,&nbsp;Ouahiba Sihali-Beloui,&nbsp;Nesrine Semiane,&nbsp;Aicha Mallek,&nbsp;Yasmina Dahmani","doi":"10.1016/j.nupar.2025.07.002","DOIUrl":"10.1016/j.nupar.2025.07.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Excessive consumption of carbohydrates often leads to central obesity, endocrine metabolic alterations, and adrenal dysfunctions. Phytoecdysteroids, a class of active natural compounds, have shown promising effects on the physiological functions of vertebrates. In this study, we investigated the impact of 20-hydroxyecdysone (20E), a specific phytoecdysteroid, on the adrenal zona fasciculata of the obese gerbil species <em>Gerbillus tarabuli</em>.</div></div><div><h3>Materials and methods</h3><div>Gerbils were fed a high-carbohydrate diet (HCD) for a period of 3 months, followed by an additional 2-month period on the same diet, with and without supplementation with 20E (50<!--> <!-->mg/kg body weight). At the end of the experimental period, we recorded body and organ weights, assessed biochemical and hormonal parameters, and analyzed the adrenal glands through histological and ultrastructural examinations.</div></div><div><h3>Results</h3><div>The HCD regimen elevated both body weight and abdominal adipose tissue in <em>Gerbillus tarabuli</em>, accompanied by hyperactivation of the HPA axis. Significantly increased levels of plasma glucose, insulin, and adrenal cortisol were also observed. Histological and ultrastructural analyses of the adrenal glands revealed important alterations, characterized by zona fasciculata disorganization, inflammatory cell infiltration, and collagen deposition. Conversely, administration of 20E led to improvements in biochemical and hormonal parameters, including significant reductions in insulin, glucose, HOMA-IR, cholesterol, and plasma adrenocorticotropic hormone levels. Although no significant changes were observed in body weight, mesenteric or subcutaneous fat mass or relative adrenal weight, we noted a significant reduction in perigonadal adipose tissue weight, underscoring its selective impact on fat distribution.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 292-301"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145595041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The metabolic promise of intermittent fasting in obesity intervention: Insights from human clinical studies","authors":"Pınar Unaldi-Daldeviren,&nbsp;Seda Ciftci","doi":"10.1016/j.nupar.2025.07.003","DOIUrl":"10.1016/j.nupar.2025.07.003","url":null,"abstract":"<div><h3>Purpose of review</h3><div>Obesity is a multifaceted condition that significantly increases the risk of metabolic disorders, including type 2 diabetes, cardiovascular diseases, hypertension, stroke, and certain cancers. Traditional dietary interventions emphasize continuous caloric restriction; however, intermittent fasting (IF) has emerged as an alternative approach that prioritizes meal timing over sustained calorie reduction. This review examines the effectiveness of IF in obesity management, highlighting its potential benefits, mechanisms of action, and clinical implications. Notably, the focus is on evidence from human clinical studies, excluding data from animal models.</div></div><div><h3>Recent findings</h3><div>IF, which includes protocols such as alternate-day fasting (ADF), modified alternate-day fasting (MADF), the 5:2 diet, and time-restricted feeding (TRF), has demonstrated efficacy in promoting weight loss, improving metabolic health, and optimizing body composition. Studies indicate that a 5–10% reduction in body weight within six months can enhance glycemic control, blood pressure, and lipid profiles, thereby reducing obesity-related complications. IF provides a sustainable approach to dietary regulation without necessitating the elimination of specific food groups. Emerging clinical evidence also suggests that beyond weight loss, IF can improve insulin sensitivity, lower blood pressure, modulate appetite-regulating hormones (e.g., leptin and adiponectin), and even reduce liver fat and enzymes associated with non-alcoholic fatty liver disease.</div></div><div><h3>Summary</h3><div>IF represents a promising dietary strategy for obesity management, offering metabolic benefits beyond weight loss. While accumulating evidence supports its effectiveness, further research is required to determine its long-term effects, optimal implementation strategies, and broader impact on metabolic health.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 240-250"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue contents","authors":"","doi":"10.1016/S0985-0562(25)00084-6","DOIUrl":"10.1016/S0985-0562(25)00084-6","url":null,"abstract":"","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Page e1"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composition of fatty acids in lipid emulsions and clinical outcomes in non-surgical critically ill patients: A systematic review and meta-analysis of randomized controlled trials","authors":"Melika Hajimohammadebrahim-Ketabforoush ,&nbsp;Amene Saghazadeh ,&nbsp;Maryam Behfar ,&nbsp;Amir Ali Hamidieh ,&nbsp;Zahra Vahdat Shariatpanahi","doi":"10.1016/j.nupar.2025.06.006","DOIUrl":"10.1016/j.nupar.2025.06.006","url":null,"abstract":"<div><h3>Background &amp; objectives</h3><div>Increasing evidence has demonstrated that lipid emulsions are an essential part of nutrition therapy for critically-ill patients who are candidates for parenteral nutrition (PN). Meanwhile, determining the optimal lipid composition remains challenging, especially in non-surgical critically-ill patients. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing fatty acids in lipid emulsions and clinical outcomes in these patients.</div></div><div><h3>Methods</h3><div>Based on our predefined search strategy, PubMed, Cochrane, and Web of Science were searched for RCTs published up to 18 October 2023. The interventions included fish oil (FO), olive oil (OO), medium-chain triglyceride (MCT), and soybean oil (SO) or their mixture and were compared with traditional emulsions mostly based on 100% SO. The clinical outcomes evaluated included infections, mechanical ventilation, intensive care unit (ICU) length of stay (LOS), hospital LOS, ICU mortality, in-hospital mortality, and long-term mortality.</div></div><div><h3>Results</h3><div>A total of 802 articles were retrieved in the first stage of our search. Based on our predefined inclusion criteria, 9 articles were eligible for entering this meta-analysis. The studies had a low to moderate risk of bias. Hospital LOS was the only statistically significant outcome with a lower value in the treatment groups compared with the controls (Hedges's g −0.45; 95% CI −0.69, −0.20; <em>P</em> <!-->=<!--> <!-->0.00; I² <!-->=<!--> <!-->8.90%). Infection was identified as another statistically significant variable (Log odds-ratio 0.77; 95% CI 0.13, 1.42; <em>P</em> <!-->=<!--> <!-->0.02; I² <!-->=<!--> <!-->0%); however, only 2 articles in this regard were included in the meta-analysis.</div></div><div><h3>Conclusion</h3><div>The results of our meta-analysis highlighted a decrease in hospital LOS and infections. However, particularly regarding infections, more future studies are required. In accordance with previous meta-analyses, this findings highlight the superiority of mixed lipid emulsions consisting of FO/OO/MCT/SO, especially based on FO, over the traditional ones mostly based on SO, in non-surgical critically-ill patients who are candidates for PN.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 230-239"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L’éditorial de la présidente de la SNFCM","authors":"Francisca Joly","doi":"10.1016/j.nupar.2025.10.001","DOIUrl":"10.1016/j.nupar.2025.10.001","url":null,"abstract":"","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Page 229"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What diet is optimal in adults with metabolic dysfunction-associated steatotic liver disease? A systematic review and network meta-analysis","authors":"Zi Zeng ,&nbsp;Hua Wei ,&nbsp;Yuejuan Dong ,&nbsp;Sijin Sun ,&nbsp;Zhuoma Sunu","doi":"10.1016/j.nupar.2025.08.004","DOIUrl":"10.1016/j.nupar.2025.08.004","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effects of various dietary regimens on adult patients with metabolic dysfunction-associated steatotic liver disease.</div></div><div><h3>Methods</h3><div>Randomized controlled trials of various dietary regimens in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), published up to October 6th, 2024, were included in this study. The Cochrane Collaboration tool was employed to assess the risk of bias for quality evaluation. STATA 17.0 software was utilized for both pairwise meta-analysis and a series of network meta-analyses (NMA).</div></div><div><h3>Results</h3><div>A total of 19 randomized controlled trials (RCTs) from 22 studies involving 1288 patients were included, focusing on 12 different dietary approaches. The findings indicated that the recommended diet varied based on different outcome measures. The very low-calorie ketogenic diet (VLCKD) was found to be the most effective for reducing body weight, body mass index (BMI), and waist circumference. In contrast, the Dietary Approaches to Stop Hypertension (DASH) was more effective in lowering blood lipid levels. Regarding liver enzyme indicators, the results were inconsistent, leading to no specific recommendations. Additionally, the low free sugar diet (LFSD) demonstrated greater benefits in improving glucose metabolism indicators.</div></div><div><h3>Conclusions</h3><div>The VLCKD is more effective for improving anthropometric indicators, while the DASH diet is more suitable for enhancing lipid indicators. There is currently no standardized dietary recommendation for alleviating liver enzyme indicators. The LFSD has proven to be more effective for parameters related to glucose metabolism indicators. Clinical applications should be tailored to the individual circumstances of each patient.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 319-333"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145595040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}