Journal of Nutrition Health & Aging最新文献

{"title":"Associations of individual beverage types and substitution with dementia risk","authors":"Huimin Wang","doi":"10.1016/j.jnha.2026.100795","DOIUrl":"10.1016/j.jnha.2026.100795","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 3","pages":"Article 100795"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current marijuana use is cross-sectionally associated with accelerated biological aging among U.S. adults: exploring mediating effect of blood cadmium","authors":"Kai Wei ,&nbsp;Xiaotong Chen","doi":"10.1016/j.jnha.2026.100778","DOIUrl":"10.1016/j.jnha.2026.100778","url":null,"abstract":"<div><h3>Background</h3><div>Global marijuana use has risen markedly in recent decades. Although prior research suggests that marijuana use is associated with epigenetic alterations, its relationship with biological aging remains unclear. This study aimed to examine the association between marijuana use and accelerated aging and explore the mediating role of metal exposure.</div></div><div><h3>Methods</h3><div>Using data from 12,806 U.S. adults (NHANES 2005–2018), biological age (BA) was calculated using two validated algorithms, phenotypic age (PhenoAge) and Klemera–Doubal biological age (KD-BioAge), with aging acceleration defined as the residuals from linear regression of BA on chronological age (CA). Marijuana use status was ascertained via standardized interviews. Analyses included survey-weighted multivariable linear regression, stratified subgroup analyses, joint exposure assessments, and mediation analyses.</div></div><div><h3>Results</h3><div>Current marijuana users exhibited significantly accelerated aging versus never users: PhenoAge acceleration (β = 0.72, 95% CI: 0.41–1.02, <em>P</em> &lt; 0.001) and KD-BioAge acceleration (β = 0.36, 95% CI: 0.14–0.59, <em>P</em> = 0.002), after full adjustment. Subgroup and joint exposure analyses showed consistent associations, with evidence of additive associations among dual users of marijuana and tobacco. Mediation analyses identified blood cadmium as a partial mediator, explaining 15.6% and 8.3% of aging acceleration for PhenoAge and KD-BioAge, respectively.</div></div><div><h3>Discussion</h3><div>This study provides robust epidemiological evidence linking marijuana use to accelerated biological aging, with blood cadmium identified as a potential mechanistic link. These findings highlight the public health importance of understanding the long-term physiological correlates of marijuana use.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 3","pages":"Article 100778"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145963128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allostatic load elevates the risk and adverse prognosis of immune-mediated inflammatory diseases: modulatory effects of lifestyle interventions and genetic susceptibility","authors":"Ziling Yang ,&nbsp;Jinming Zhang ,&nbsp;Zhong Qu ,&nbsp;Zhuo Zhao ,&nbsp;Yajuan Zheng","doi":"10.1016/j.jnha.2026.100792","DOIUrl":"10.1016/j.jnha.2026.100792","url":null,"abstract":"<div><h3>Background</h3><div>Allostatic load (AL)—the cumulative biological cost of lifelong stress—can disrupt immune homeostasis via hypothalamic–pituitary–adrenal-axis dysregulation and persistent sympathetic activation. Immune-mediated inflammatory diseases (IMIDs) are organ-specific chronic inflammatory disorders imposing a major public-health burden, yet their causal link with AL remains unclear.</div></div><div><h3>Methods</h3><div>In this prospective study of 186 310 UK Biobank participants, Cox proportional-hazards models quantified dose-response associations between AL and the incidence of ten IMIDs plus all-cause mortality. Interaction models evaluated the modifying effects of physical activity, ω-3 polyunsaturated fatty acids (ω-3 PUFAs) and other lifestyle variables, and assessed gene–environment interplay using polygenic risk scores (PRS).</div></div><div><h3>Results</h3><div>Compared with the lowest AL quartile, the highest quartile showed significantly greater incidence of rheumatoid arthritis (hazard ratios (HR) = 1.52), spondyloarthritis (HR = 2.50), asthma (HR = 1.38), inflammatory bowel disease (IBD) (HR = 1.19), type 1 diabetes (T1DM) (HR = 5.16), psoriasis (HR = 1.87), autoimmune retinopathy (HR = 1.77) and composite IMIDs (HR = 1.55) (all p &lt; 0.05). Elevated AL also predicted dose-dependent increases in all-cause mortality among patients with rheumatoid arthritis (HR = 6.59), asthma (HR = 1.87), IBD (HR = 2.00), T1DM (HR = 2.72) and composite IMIDs (HR = 2.01). Sufficient physical activity and higher ω-3 PUFA intake partially attenuated AL-related risks, whereas high PRS synergistically amplified AL effects for spondyloarthritis (attributable proportion (AP) = 7.6%), T1DM (AP = 4.7%) and psoriasis (AP = 4.9%).</div></div><div><h3>Conclusions</h3><div>AL is causally linked to both the development and prognosis of IMIDs, with its impact jointly modifiable by lifestyle factors and genetic susceptibility. Building AL-centred psychoneuroimmunological biomarker networks may enable refined risk stratification and precision interventions for IMIDs.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 3","pages":"Article 100792"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between vitamin intake and biological aging: evidence from NHANES 2007–2018","authors":"Xinyu Zhang ,&nbsp;Yujie Xu ,&nbsp;Xiaoyu Wang ,&nbsp;Mengxue Chen ,&nbsp;Jingyuan Xiong ,&nbsp;Guo Cheng","doi":"10.1016/j.jnha.2026.100776","DOIUrl":"10.1016/j.jnha.2026.100776","url":null,"abstract":"<div><h3>Background</h3><div>The combined effect of vitamin mixture on biological aging, along with the specific contribution of individual components, remains unclear. This study investigated the associations between a mixture of 11 dietary vitamins and biological aging.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 15050 adults from NHANES 2007–2018. Daily intakes of 11 vitamins were estimated using the multiple source method to account for within-person variation from two 24 -h recalls, incorporating both food and supplement contributions. Total vitamin intake was calculated as their sum. Biological aging was assessed using three established indicators: KDM-acceleration and PhenoAge-acceleration (derived as regression residuals of biological age on chronological age), and homeostatic dysregulation (HD, a composite physiological score). Multiple linear regression, restricted cubic spline regression, and quantile g-computation were used to assess individual and joint associations.</div></div><div><h3>Results</h3><div>The median age was 51.0 years, and 51.5% were female. Higher total vitamin intake was significantly associated with reduced biological aging (KDM-acceleration: β = −1.281; PhenoAge-acceleration: β = −1.379; HD: β = −0.046). Dose-response relationships were linear (all <em>P</em>_nonlinear &gt; 0.05). Stratified analyses revealed stronger associations in males and individuals with comorbidity. Vitamin C was the primary protective component, followed by vitamin B2.</div></div><div><h3>Conclusions</h3><div>Higher intake of dietary vitamin mixture was associated with slower biological aging, with vitamin C as the key protective driver. These findings support recommending vitamin-rich diets to promote healthy aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 2","pages":"Article 100776"},"PeriodicalIF":4.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to the Mediterranean Diet and frailty criteria in an old population with metabolic syndrome: A cross-sectional analysis","authors":"Macarena Torrego-Ellacuría ,&nbsp;Federico Cuesta-Triana ,&nbsp;María Ortiz-Ramos ,&nbsp;Miguel Ángel Martínez-González ,&nbsp;Dolores Corella ,&nbsp;Héctor Vázquez-Lorente ,&nbsp;Montserrat Fitó ,&nbsp;José Alfredo Martínez ,&nbsp;Lucas Tojal-Sierra ,&nbsp;Julia Wärnberg ,&nbsp;Jesús Vioque ,&nbsp;Dora Romaguera ,&nbsp;José López-Miranda ,&nbsp;Ramon Estruch ,&nbsp;Francisco J Tinahones ,&nbsp;José Manuel Santos-Lozano ,&nbsp;J. Luís Serra-Majem ,&nbsp;Aurora Bueno-Cavanillas ,&nbsp;Josep A. Tur ,&nbsp;Juan Carlos Romero Vigara ,&nbsp;Pilar Matía-Martín","doi":"10.1016/j.jnha.2025.100757","DOIUrl":"10.1016/j.jnha.2025.100757","url":null,"abstract":"<div><h3>Objectives</h3><div>Frailty has emerged as a key indicator of biological aging. This study aimed to assess the relationship between MedDiet adherence and frailty prevalence in the context of metabolic syndrome (MetS).</div></div><div><h3>Design</h3><div>Cross-sectional study. Baseline data from PREDIMED-Plus trial</div></div><div><h3>Setting</h3><div>Primary care health, 23 recruitment sites (2013–2016).</div></div><div><h3>Participants</h3><div>A total of 6874 participants with overweight/obesity and ≥3 MetS components.</div></div><div><h3>Measurements</h3><div>Adherence to the MedDiet: 17-item MedDiet score. Frailty and prefrailty (3 or 1–2 criteria): modified Fried Frailty Index (FFI), considering exhaustion, physical activity and functional capacity. Main independent variable was analysed: as a continuous variable (range: 0–17); in quartiles of adherence using univariate and multivariate logistic regression models adjusted for potential confounders.</div></div><div><h3>Results</h3><div>Prefrailty and frailty prevalence were 49.7% and 2.9%, respectively. Compared to those with the lowest MedDiet adherence (0–6), participants with the highest adherence (11–17) had significantly lower odds of meeting frailty criteria. Fully adjusted models showed ORs of 0.479 (p = 0.097) for frailty, 0.705 (p = 0.001) for prefrailty, and 0.694 (p = 0.001) for frailty or prefrailty in participants with higher/greater MedDiet adherence. Each 1-point increase in the 17-item score was associated with an OR ranging from 0.878 to 0.977 (p &lt; 0.05 for all comparisons, except functional capacity: p = 0.100). When adherence was dichotomized, the adjusted ORs ranged from 0.406 to 0.834 (p &lt; 0.05 for all comparisons).</div></div><div><h3>Conclusions</h3><div>Higher adherence to MedDiet was associated with a lower prevalence of frailty and prefrailty in older adults with overweight/obesity and MetS, reinforcing its potential role in promoting healthy aging despite cardiometabolic comorbidities.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 2","pages":"Article 100757"},"PeriodicalIF":4.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity and risk of hip fracture in older adults: evidence from five multinational aging cohorts","authors":"Xiaoming Zhang ,&nbsp;Deji Xu ,&nbsp;Yunzhi Yang ,&nbsp;Yufei Zeng ,&nbsp;Huilin Yu ,&nbsp;Tengfei Fang ,&nbsp;Ke Zhu ,&nbsp;Yi Xiao ,&nbsp;Jiang Wang ,&nbsp;Qingli Dou ,&nbsp;Wenwu Zhang","doi":"10.1016/j.jnha.2026.100773","DOIUrl":"10.1016/j.jnha.2026.100773","url":null,"abstract":"<div><h3>Background</h3><div>Hip fracture poses a substantial threat to the quality of life in older adults. Evidence regarding the association between intrinsic capacity (IC) and hip fracture is limited. This study aimed to investigate the relationship between IC and hip fracture risk in older populations.</div></div><div><h3>Methods</h3><div>This multi-cohort study included five nationally representative aging cohorts: the China Health and Retirement Longitudinal Study (CHARLS), the Health and Retirement Study (HRS), the Mexican Health and Aging Study (MHAS), the Survey of Health, Ageing and Retirement in Europe (SHARE), and the English Longitudinal Study of Ageing (ELSA). Participants aged 60 years and older with baseline IC assessments and at least two follow-ups were included. Individuals with baseline hip fracture, missing hip fracture data, missing covariate data, or lost to follow-up were excluded. IC was comprehensively evaluated across five domains: cognition, locomotion, vitality, sensory function, and psychological function. Hip fractures were identified through self-report or physician diagnosis. Cox proportional hazards regression models were used to estimate the association between IC and hip fracture, and results were pooled across cohorts using a common-effects meta-analysis.</div></div><div><h3>Results</h3><div>A total of 37,267 participants were included, with hip fracture prevalence ranging from 1.40% in SHARE to 4.64% in CHARLS. Higher IC was significantly associated with lower hip fracture risk in all cohorts: CHARLS (HR = 0.75, 95% CI [0.67–0.84]), HRS (HR = 0.65, 95% CI [0.53–0.78]), MHAS (HR = 0.77, 95% CI [0.63–0.95]), SHARE (HR = 0.83, 95% CI [0.72–0.95]), and ELSA (HR = 0.74, 95% CI [0.57–0.98]). The pooled estimate from the common-effects model was HR = 0.76 (95% CI [0.71–0.81], I² = 10.7%). In addition, Sensitivity analyses further supported the robustness of these findings.</div></div><div><h3>Conclusions</h3><div>Higher IC is associated with a lower risk of hip fracture among older adults. IC may serve as an early predictive indicator of hip fracture, supporting preventive strategies to reduce the economic and societal burden of hip fractures and to preserve quality of life in aging populations.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 2","pages":"Article 100773"},"PeriodicalIF":4.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of post-stroke changes in body mass index with activity of daily living and instrumental activity of daily living trajectories: A multi-cohort analysis.","authors":"Guillaume Chambinaud, Aurore Fayosse, Aline Dugravot, Benjamin Landré, Alexis Schnitzler, Archana Singh-Manoux, Séverine Sabia, Louis Jacob","doi":"10.1016/j.jnha.2026.100772","DOIUrl":"10.1016/j.jnha.2026.100772","url":null,"abstract":"<p><strong>Objectives: </strong>The determinants of functional limitation trajectories after stroke remain scarce. This study aimed to investigate the association of early body mass index (BMI) changes with trajectories of activities of daily living (ADLs) and instrumental activities of daily living (IADLs) following stroke.</p><p><strong>Design: </strong>Three cohorts from Europe and the United States.</p><p><strong>Setting: </strong>Community.</p><p><strong>Participants: </strong>Stroke survivors.</p><p><strong>Measurements: </strong>BMI changes were assessed 1-4 years after self-reported stroke and categorized as decreased (≤-5% initial BMI), increased (≥5% initial BMI), and stable. An alternate cut-point of 2% was also used. Functional limitations were measured as the number of ADL and IADL limitations, which were repeatedly measured for up to 24 years after stroke. Associations were evaluated using segmented linear mixed-effects models after adjusting for demographic, behavioral, and medical factors.</p><p><strong>Results: </strong>The study population comprised 2544 adults with stroke (mean [standard deviation] age 70.0 [10.9] years; 52.0% women). Based on a 5% cutoff, the number of ADL and IADL limitations was higher in the groups of decreased (ADL: 0.56 [95% CI = 0.28, 0.85]; IADL: 0.66 [95% CI = 0.38, 0.94]) and increased BMI (ADL: 0.55 [95% CI = 0.28, 0.81]; IADL: 0.59 [95% CI = 0.33, 0.85]) compared to stable BMI, respectively. Similar findings were obtained for a 2% cutoff. These differences frequently persisted for 24 years for decreased BMI and 6-12 years for increased BMI.</p><p><strong>Conclusion: </strong>Early decreased BMI, and to a lesser extent increased BMI, following stroke could be a marker of long-term adverse trajectories of physical functioning, underlying the importance of nutritional and physical activity management after a stroke.</p>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 2","pages":"100772"},"PeriodicalIF":4.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12901523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between dietary patterns and the incidence of idiopathic pulmonary fibrosis: A cohort study","authors":"Yonghao Li ,&nbsp;Xinran Dou ,&nbsp;Hui Li ,&nbsp;Xuan Li ,&nbsp;Luqin Yang ,&nbsp;Jiawei Chen ,&nbsp;Fengqin Zhang ,&nbsp;Huihui Yue ,&nbsp;Ruihan Dong ,&nbsp;Jianhan He ,&nbsp;Xuewen Wang ,&nbsp;Wei Wei ,&nbsp;Li Liu ,&nbsp;Huilan Zhang","doi":"10.1016/j.jnha.2025.100755","DOIUrl":"10.1016/j.jnha.2025.100755","url":null,"abstract":"<div><h3>Background</h3><div>Idiopathic pulmonary fibrosis (IPF) is a progressive, age-related lung disease with few modifiable risk factors. While healthy dietary patterns have been associated with reduced risk of chronic diseases, their impact on IPF remains unclear. This study investigated the relationship between adherence to healthy dietary patterns and incident IPF and explored whether phenotypic age acceleration mediates this association.</div></div><div><h3>Methods</h3><div>We analyzed 196,473 participants from the UK Biobank. Dietary intake was assessed via repeated 24 -h recall questionnaires, and adherence scores were calculated for the DASH, MEDAS, and MIND dietary patterns. Cox proportional hazards models were used to estimate the association between dietary scores and incident IPF. Mediation analysis was conducted to examine the role of phenotypic age acceleration.</div></div><div><h3>Results</h3><div>During a median follow-up of 12.4 years, 516 IPF cases were identified. Higher adherence to all three dietary patterns was significantly associated with a reduced risk of IPF. In fully adjusted models, hazard ratios for the highest vs. lowest quartiles were 0.75 (95% CI: 0.59–0.95) for DASH, 0.53 (0.37–0.75) for MEDAS, and 0.66 (0.51–0.86) for MIND. Phenotypic age acceleration partially mediated these associations.</div></div><div><h3>Conclusions</h3><div>Higher dietary scores were associated with a lower risk of incident IPF, partially mediated by reduced phenotypic age acceleration. These findings suggest that promoting healthy eating habits may contribute to reducing age-related lung disease burden in older adults.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 2","pages":"Article 100755"},"PeriodicalIF":4.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145749500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomy, disruptions and coping strategies of community-dwelling older adults in food-related activities - food shopping, cooking and eating- a scoping review","authors":"Hélène Trimaille ,&nbsp;Yoshimasa Sagawa ,&nbsp;Aline Chassagne","doi":"10.1016/j.jnha.2025.100769","DOIUrl":"10.1016/j.jnha.2025.100769","url":null,"abstract":"<div><h3>Background</h3><div>Food-related activities—shopping, cooking, and eating—play a critical role in enabling community-dwelling older adults to live and age in place.</div></div><div><h3>Objectives</h3><div>This scoping review aims to explore existing knowledge on the experiences of community-dwelling older adults in their food-related activities. It also seeks to identify which stages of these activities have been studied.</div></div><div><h3>Method</h3><div>A systematic search of four databases (2000–2023) identified 1,189 articles. After screening, 48 studies were included. Data were analysed to determine which stages of food-related activities were examined and to extract emerging themes.</div></div><div><h3>Results</h3><div>Of the 48 studies, 31% addressed all three stages, 14% focused on two stages, and 54% examined one stage. This review highlights the complex interplay of social, cultural, economic, political, and health environments that structure food-related activities. Disruptions within these environments challenge autonomy. Depending on their social roles, interests, skills, and knowledge, older adults develop coping strategies to maintain control over their food-related activities.</div></div><div><h3>Conclusion</h3><div>The findings underscore the need for ethical, person-centered support from healthcare and social service professionals, as well as relatives. Support should respect the decision-making autonomy of older adults while offering tailored nutritional guidance that enables them to adapt their food-related activities to evolving needs.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 2","pages":"Article 100769"},"PeriodicalIF":4.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lycopene, Race and Periodontitis: Disparities in Older Adults","authors":"Katherine Kwong ,&nbsp;You Lu ,&nbsp;ZhuoHuan Li ,&nbsp;Susu Luo ,&nbsp;Zhaoyu Huang ,&nbsp;Zhong Chen ,&nbsp;Na Zhao ,&nbsp;Tung-Sung Tseng","doi":"10.1016/j.jnha.2025.100759","DOIUrl":"10.1016/j.jnha.2025.100759","url":null,"abstract":"<div><h3>Background</h3><div>Periodontitis is a severe gum disease that can be an indicator of other health conditions such as cardiovascular disease and diabetes. Lycopene has been suggested as an adjunct therapy for periodontitis. This study aims to investigate the association between insufficient lycopene intake and the risk of Periodontitis among non-Hispanic White (NHW) and non-Hispanic Black (NHB) older adults.</div></div><div><h3>Methods</h3><div>The study included 1,227 adults aged 65–79 years from the National Health and Nutritional Examination Survey (2009–2014). Total lycopene intake from daily diet was studied with age, race, marital status, smoking status, BMI, diabetes, sex, and education as independent variables in regression model.</div></div><div><h3>Results</h3><div>Overall, 48.7% of the older adults exhibited varying degrees of PD, and 49.1% had insufficient dietary lycopene intake. Adequate lycopene intake was associated with a reduced likelihood of severe PD (odds ratio (O.R.): 0.33; 95%CI: 0.17−0.65). NHBs were more prone to developing severe PD compared to NHWs (O.R.: 2.82, 95%CI: 1.46−5.45). Women exhibiting a lower likelihood of severe PD than men (O.R.: 0.27; 95% CI: 0.14−0.55). NHW females, who were less likely to have severe PD compared to NHW males (O.R.: 0.26; 95% CI: 0.12−0.56).</div></div><div><h3>Conclusion</h3><div>Dietary lycopene intake is associated with reduced risk of severe PD, particularly in NHW individuals over 65 years old. PD was more common in men and NHB individuals, with a latter group showing a higher prevalence of severe PD. Our results suggest that future PD prevention strategies should consider targeted, race-and sex-specific dietary interventions.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 2","pages":"Article 100759"},"PeriodicalIF":4.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}