Pub Date : 2025-11-01Epub Date: 2025-09-29DOI: 10.1016/j.jnha.2025.100689
Ho Chen , Eri Maeda , Wen Hao , Kenji Wakai , Satoe Okabayashi , Shigekazu Ukawa , Akiko Tamakoshi
Objectives
Geriatric depression is an increasingly important public health issue in an aging society. However, while Japan boasts one of the world’s highest and healthiest life expectancies at birth, there was no prospective cohort study dedicated to the specific association between the Japanese diet and geriatric depression. Thus, we aimed to examine this relationship and assess whether such association extends beyond better physical health secondary to higher diet quality.
Design, setting, participants, and measurements
Our study utilized the New Integrated Suburban Seniority Investigation (NISSIN) Project, which is an age-specific prospective cohort study that recruited residents of Nisshin City, Japan who were about to reach 65 years of age between 1996 and 2005. We measured the adherence to the Japanese diet of 1620 elderly Japanese individuals (827 male and 793 female) with a modified version of the Japanese Diet Index (JDI) and assessed the development of geriatric depression with the Geriatric Depression Scale 15 items questionnaire when they reached 70 years of age.
Results
A total of 135 individuals developed geriatric depression at 70 years of age. After adjusting for major confounding factors, those within the highest group of adherence to the Japanese diet had significantly reduced risk of developing geriatric depression (adjusted odds ratio [aOR] = 0.525, 95% confidence interval [CI]: 0.286 – 0.962) when compared to those with the lowest adherence, and each point received on the JDI was also associated with reduced risk of geriatric depression (aOR = 0.900, 95% CI: 0.816−0.992). Dietary item-wise analyses showed that fish and shellfish (p = 0.024), green-yellow vegetable (p = 0.003), and soybean-derived products (p = 0.001) were significantly associated with lower risk of geriatric depression.
Conclusion
Adherence to the Japanese diet, especially those rich in green-yellow vegetables, soybean-derived products, and fish and shellfish, may be protective against geriatric depression.
{"title":"Adherence to the Japanese Diet is Associated with Lower Risk of Geriatric Depression: A Prospective-Cohort Study Based on the New Integrated Suburban Seniority Investigation (NISSIN) Project","authors":"Ho Chen , Eri Maeda , Wen Hao , Kenji Wakai , Satoe Okabayashi , Shigekazu Ukawa , Akiko Tamakoshi","doi":"10.1016/j.jnha.2025.100689","DOIUrl":"10.1016/j.jnha.2025.100689","url":null,"abstract":"<div><h3>Objectives</h3><div>Geriatric depression is an increasingly important public health issue in an aging society. However, while Japan boasts one of the world’s highest and healthiest life expectancies at birth, there was no prospective cohort study dedicated to the specific association between the Japanese diet and geriatric depression. Thus, we aimed to examine this relationship and assess whether such association extends beyond better physical health secondary to higher diet quality.</div></div><div><h3>Design, setting, participants, and measurements</h3><div>Our study utilized the New Integrated Suburban Seniority Investigation (NISSIN) Project, which is an age-specific prospective cohort study that recruited residents of Nisshin City, Japan who were about to reach 65 years of age between 1996 and 2005. We measured the adherence to the Japanese diet of 1620 elderly Japanese individuals (827 male and 793 female) with a modified version of the Japanese Diet Index (JDI) and assessed the development of geriatric depression with the Geriatric Depression Scale 15 items questionnaire when they reached 70 years of age.</div></div><div><h3>Results</h3><div>A total of 135 individuals developed geriatric depression at 70 years of age. After adjusting for major confounding factors, those within the highest group of adherence to the Japanese diet had significantly reduced risk of developing geriatric depression (adjusted odds ratio [aOR] = 0.525, 95% confidence interval [CI]: 0.286 – 0.962) when compared to those with the lowest adherence, and each point received on the JDI was also associated with reduced risk of geriatric depression (aOR = 0.900, 95% CI: 0.816−0.992). Dietary item-wise analyses showed that fish and shellfish (p = 0.024), green-yellow vegetable (p = 0.003), and soybean-derived products (p = 0.001) were significantly associated with lower risk of geriatric depression.</div></div><div><h3>Conclusion</h3><div>Adherence to the Japanese diet, especially those rich in green-yellow vegetables, soybean-derived products, and fish and shellfish, may be protective against geriatric depression.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100689"},"PeriodicalIF":4.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-09-03DOI: 10.1016/j.jnha.2025.100669
Xingchen He , Yaxuan Yan , Jiawen Wang , Yijia Lin , Xinyi Wu , Min Li , Tianyu Zhong , Xuliang Weng
{"title":"Nonlinear Dose-Response and Calcium-Magnesium Interactions of Dietary Minerals with Cognitive Function in Older Adults","authors":"Xingchen He , Yaxuan Yan , Jiawen Wang , Yijia Lin , Xinyi Wu , Min Li , Tianyu Zhong , Xuliang Weng","doi":"10.1016/j.jnha.2025.100669","DOIUrl":"10.1016/j.jnha.2025.100669","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100669"},"PeriodicalIF":4.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-09-23DOI: 10.1016/j.jnha.2025.100690
Kylie Kavanagh , Taylor Sheridan , Ravichandra Vemuri , Aleaya Bowie , Darla DeStephanis , Shannon Kraniak , Elizabeth Burner , McKinley Santiago
Objective
To assess the relationship between fecal Faecalibacterium prausnitzii and health resiliency.
Design
Cohorts of nonhuman primates were evaluated prior to disease development for fecal abundances of Faecalibacterium prausnitzii.
Setting
Radiation-induced and spontaneously arising age-induced morbidity and mortality, including high rates of Type 2 diabetes.
Participants
Old world male and female nonhuman primates.
Measurements
Age, weight, glycemic indices, fecal total microbial loads and specific detection Faecalibacterium prausnitzii levels as measured by whole genome sequencing or polymerase chain reaction.
Results
Higher levels of fecal Faecalibacterium prausnitzii was observed in nonhuman primates that survived whole body irradiation, had longer lifespans, and were protected from future Type 2 diabetes diagnoses. Type 2 diabetes development further lowered Faecalibacterium prausnitzii levels. The mean effect size for differences in fecal abundance was 1.76 (95% confidence interval 0.03–3.50).
Conclusion
The abundance of the intestinal microbial species Faecalibacterium prausnitzii appears to be a strong candidate biomarker species for a preferred microbiome that predicts superior health resiliency and associated lifespan.
{"title":"Faecalibacterium prausnitzii Indicates Healthspan and Lifespan in Nonhuman Primates","authors":"Kylie Kavanagh , Taylor Sheridan , Ravichandra Vemuri , Aleaya Bowie , Darla DeStephanis , Shannon Kraniak , Elizabeth Burner , McKinley Santiago","doi":"10.1016/j.jnha.2025.100690","DOIUrl":"10.1016/j.jnha.2025.100690","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the relationship between fecal <em>Faecalibacterium prausnitzii</em> and health resiliency.</div></div><div><h3>Design</h3><div>Cohorts of nonhuman primates were evaluated prior to disease development for fecal abundances of <em>Faecalibacterium prausnitzii.</em></div></div><div><h3>Setting</h3><div>Radiation-induced and spontaneously arising age-induced morbidity and mortality, including high rates of Type 2 diabetes.</div></div><div><h3>Participants</h3><div>Old world male and female nonhuman primates.</div></div><div><h3>Measurements</h3><div>Age, weight, glycemic indices, fecal total microbial loads and specific detection <em>Faecalibacterium prausnitzii</em> levels as measured by whole genome sequencing or polymerase chain reaction.</div></div><div><h3>Results</h3><div>Higher levels of fecal <em>Faecalibacterium prausnitzii</em> was observed in nonhuman primates that survived whole body irradiation, had longer lifespans, and were protected from future Type 2 diabetes diagnoses. Type 2 diabetes development further lowered <em>Faecalibacterium prausnitzii</em> levels. The mean effect size for differences in fecal abundance was 1.76 (95% confidence interval 0.03–3.50).</div></div><div><h3>Conclusion</h3><div>The abundance of the intestinal microbial species <em>Faecalibacterium prausnitzii</em> appears to be a strong candidate biomarker species for a preferred microbiome that predicts superior health resiliency and associated lifespan.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100690"},"PeriodicalIF":4.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The World Health Organization's Integrated Care for Older People framework emphasizes intrinsic capacity (IC) assessment, yet the relationship between specific intrinsic capacity impairments and self-rated health (SRH) across different age groups remains inadequately characterized.
Objectives
To analyze age-specific associations between six IC domains and self-rated health using Taiwan Longitudinal Study on Aging data, adjusting for demographic, socioeconomic, and health factors.
Methods
We extracted 3,330 participants with good or poor self-rated health, stratified into three age groups: 55−64 years (n = 1,278), 65−74 years (n = 1,011), and 75+ years (n = 1,041). Five sequential logistic regression models assessed associations between IC impairments (locomotor capacity, vitality, vision, hearing, cognition, psychological capacity) and self-rated health, adjusting for sex, education, marital status, employment, economic satisfaction, chronic conditions, smoking, drinking, physical exercise, and sleep quality.
Results
IC impairment prevalence increased with age: 17.2% (55−64), 38.2% (65−74), and 61.5% (75+). After adjustment, age-specific patterns of IC impairments associated with poor self-rated health emerged. In middle-aged adults (55−64), locomotor capacity showed the strongest association with poor self-rated health (OR = 14.61, 95% CI: 3.50–61.01), though the wide confidence interval reflects the low prevalence of impairment. Psychological capacity (OR = 5.96, 95% CI: 3.32–10.69) could thus be the most dominant IC impairment that is linked to poor self-rated health in this age group. For young-old adults (65−74), locomotor capacity had the greatest impact (OR = 4.19, 95% CI: 2.02–8.67), followed by psychological capacity (OR = 3.68, 95% CI: 2.33–5.82) and vitality (OR = 2.14, 95% CI: 1.11–4.16). In the oldest adults (75+), vitality became particularly important (OR = 4.17, 95% CI: 2.22–7.84), alongside with psychological capacity (OR = 3.15, 95% CI: 2.18–4.56) and locomotor capacity (OR = 2.20, 95% CI: 1.52–3.17).
Conclusions
Age-specific patterns suggest targeted interventions: mental health support for middle-aged adults, mobility preservation for young-old adults, and vitality enhancement for the oldest adults. These findings provide guidance for age-tailored ICOPE strategies.
{"title":"Age-specific associations between intrinsic capacity impairments and self-rated health in community-dwelling adults: Insights from Taiwan longitudinal study on aging","authors":"Sheng-Ping Chu , Chi-Yun Wu , Hsi-Yu Lai , I-Tzu Chen , Lin-Chieh Meng , Chih-Kuang Liang , Ming-Yueh Chou , Wei-Ju Lee , Liang-Kung Chen , Fei-Yuan Hsiao","doi":"10.1016/j.jnha.2025.100688","DOIUrl":"10.1016/j.jnha.2025.100688","url":null,"abstract":"<div><h3>Background</h3><div>The World Health Organization's Integrated Care for Older People framework emphasizes intrinsic capacity (IC) assessment, yet the relationship between specific intrinsic capacity impairments and self-rated health (SRH) across different age groups remains inadequately characterized.</div></div><div><h3>Objectives</h3><div>To analyze age-specific associations between six IC domains and self-rated health using Taiwan Longitudinal Study on Aging data, adjusting for demographic, socioeconomic, and health factors.</div></div><div><h3>Methods</h3><div>We extracted 3,330 participants with good or poor self-rated health, stratified into three age groups: 55−64 years (n = 1,278), 65−74 years (n = 1,011), and 75+ years (n = 1,041). Five sequential logistic regression models assessed associations between IC impairments (locomotor capacity, vitality, vision, hearing, cognition, psychological capacity) and self-rated health, adjusting for sex, education, marital status, employment, economic satisfaction, chronic conditions, smoking, drinking, physical exercise, and sleep quality.</div></div><div><h3>Results</h3><div>IC impairment prevalence increased with age: 17.2% (55−64), 38.2% (65−74), and 61.5% (75+). After adjustment, age-specific patterns of IC impairments associated with poor self-rated health emerged. In middle-aged adults (55−64), locomotor capacity showed the strongest association with poor self-rated health (OR = 14.61, 95% CI: 3.50–61.01), though the wide confidence interval reflects the low prevalence of impairment. Psychological capacity (OR = 5.96, 95% CI: 3.32–10.69) could thus be the most dominant IC impairment that is linked to poor self-rated health in this age group. For young-old adults (65−74), locomotor capacity had the greatest impact (OR = 4.19, 95% CI: 2.02–8.67), followed by psychological capacity (OR = 3.68, 95% CI: 2.33–5.82) and vitality (OR = 2.14, 95% CI: 1.11–4.16). In the oldest adults (75+), vitality became particularly important (OR = 4.17, 95% CI: 2.22–7.84), alongside with psychological capacity (OR = 3.15, 95% CI: 2.18–4.56) and locomotor capacity (OR = 2.20, 95% CI: 1.52–3.17).</div></div><div><h3>Conclusions</h3><div>Age-specific patterns suggest targeted interventions: mental health support for middle-aged adults, mobility preservation for young-old adults, and vitality enhancement for the oldest adults. These findings provide guidance for age-tailored ICOPE strategies.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100688"},"PeriodicalIF":4.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01Epub Date: 2025-08-26DOI: 10.1016/j.jnha.2025.100650
Anna Rudzińska , Gulistan Bahat , Gülçin Özalp , Serdar Özkök , Sumru Savas , Biljana Petreska-Zovic , André Rodrigues , Evrydiki Kravvariti , Anne Wissendorff Ekdahl , Sofia Duque , Mirko Petrovic , Marina Kotsani , Karolina Piotrowicz
Objectives
High quality nutrition and medical nutrition therapy in long-term care (LTC) settings are essential to overcome malnutrition and ensure a better quality of life. Heterogenous and often insufficient regulations contribute to a disparity in nutritional practices across Europe. The aim of the study was to gather information on nutrition-related regulations and practices, as well as establish potential future directions in LTC settings in five European countries: Greece, North Macedonia, Poland, Portugal and Türkiye.
Design
A country-specific literature review was conducted, including analysis of national regulations on nutrition in LTC settings. Additionally, the authors discussed possible future directions for each of the areas included in the review.
Results
In all the countries included regulations regarding the nutrition of LTC residents were identified. Countries differed in the availability of nutritional guidelines for this specific population, the requirement to employ a dietitian, and the presence of a mandatory nutritional assessment. No country-specific tools were identified for screening, assessment and diagnosing malnutrition. Meals are adapted in all countries to accommodate religious and/or cultural dietary preferences.
Conclusion
Areas for significant improvement were identified in all countries. The exchange of experiences between different European countries can lead to the development of good practices and a common direction for quality improvement regulations for nutritional care in LTC.
{"title":"Nutritional practices in long-term care across five European countries: Findings from the COST Action PROGRAMMING","authors":"Anna Rudzińska , Gulistan Bahat , Gülçin Özalp , Serdar Özkök , Sumru Savas , Biljana Petreska-Zovic , André Rodrigues , Evrydiki Kravvariti , Anne Wissendorff Ekdahl , Sofia Duque , Mirko Petrovic , Marina Kotsani , Karolina Piotrowicz","doi":"10.1016/j.jnha.2025.100650","DOIUrl":"10.1016/j.jnha.2025.100650","url":null,"abstract":"<div><h3>Objectives</h3><div>High quality nutrition and medical nutrition therapy in long-term care (LTC) settings are essential to overcome malnutrition and ensure a better quality of life. Heterogenous and often insufficient regulations contribute to a disparity in nutritional practices across Europe. The aim of the study was to gather information on nutrition-related regulations and practices, as well as establish potential future directions in LTC settings in five European countries: Greece, North Macedonia, Poland, Portugal and Türkiye.</div></div><div><h3>Design</h3><div>A country-specific literature review was conducted, including analysis of national regulations on nutrition in LTC settings. Additionally, the authors discussed possible future directions for each of the areas included in the review.</div></div><div><h3>Results</h3><div>In all the countries included regulations regarding the nutrition of LTC residents were identified. Countries differed in the availability of nutritional guidelines for this specific population, the requirement to employ a dietitian, and the presence of a mandatory nutritional assessment. No country-specific tools were identified for screening, assessment and diagnosing malnutrition. Meals are adapted in all countries to accommodate religious and/or cultural dietary preferences.</div></div><div><h3>Conclusion</h3><div>Areas for significant improvement were identified in all countries. The exchange of experiences between different European countries can lead to the development of good practices and a common direction for quality improvement regulations for nutritional care in LTC.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100650"},"PeriodicalIF":4.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01Epub Date: 2025-08-27DOI: 10.1016/j.jnha.2025.100664
Longqing Yu
{"title":"Letter to the editor concerning ‘Creatinine and cystatin C-based indices for predicting sarcopenia, frailty and disability in older community-dwelling adults’","authors":"Longqing Yu","doi":"10.1016/j.jnha.2025.100664","DOIUrl":"10.1016/j.jnha.2025.100664","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100664"},"PeriodicalIF":4.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01Epub Date: 2025-08-29DOI: 10.1016/j.jnha.2025.100665
Ángel Buendía-Romero , Enrique Higueras-Liébana , Luis M. Alegre , Ignacio Ara , Pedro L. Valenzuela
{"title":"Centenarian athletes: The paradigm of healthy longevity?","authors":"Ángel Buendía-Romero , Enrique Higueras-Liébana , Luis M. Alegre , Ignacio Ara , Pedro L. Valenzuela","doi":"10.1016/j.jnha.2025.100665","DOIUrl":"10.1016/j.jnha.2025.100665","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100665"},"PeriodicalIF":4.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01Epub Date: 2025-09-09DOI: 10.1016/j.jnha.2025.100655
Caiyun Li, Fei Xia, Yang Ni, Yiwen Liu
Background
Frailty is increasingly recognized as a predictor of poor outcomes in acute neurological conditions. However, its impact on the short-term prognosis of patients with intracranial hemorrhage (ICrH) remains unclear. This meta-analysis aimed to evaluate the association between frailty and short-term mortality and functional outcomes in patients with ICrH.
Methods
A systematic literature search was conducted in PubMed, Embase, and Web of Science from inception to February 10, 2025. Cohort studies evaluating the association between frailty and prognosis in ICrH patients were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model by incorporating the influence of heterogeneity.
Results
Twelve cohort studies involving 70,664 patients with ICrH were included. Frailty was significantly associated with increased short-term mortality (OR: 1.79, 95% CI: 1.36–2.35, p < 0.001; I2 = 72%) and poor functional outcome (OR: 1.75, 95% CI: 1.33–2.30, p < 0.001; I2 = 67%). Subgroup analyses were performed for mortality outcomes and confirmed consistent associations across different patient demographics, frailty assessment tools, and follow-up durations (p for subgroup difference all >0.05). Sensitivity analyses by excluding one study at a time showed similar results (p all < 0.05), which demonstrated robustness.
Conclusion
Our study suggests that frailty may be associated with an increased risk of short-term mortality and poor functional outcomes in patients with ICrH. These findings highlight the importance of frailty assessment in risk stratification and clinical decision-making for ICrH patients.
背景：衰弱越来越被认为是急性神经系统疾病预后不良的预测因素。然而，其对颅内出血（ICrH）患者短期预后的影响尚不清楚。本荟萃分析旨在评估ICrH患者虚弱、短期死亡率和功能结局之间的关系。方法系统检索PubMed、Embase、Web of Science自建站至2025年2月10日的文献。纳入了评估ICrH患者虚弱与预后之间关系的队列研究。比值比（ORs）和95%置信区间（ci）通过纳入异质性影响的随机效应模型进行汇总。结果纳入12项队列研究，涉及70,664例ICrH患者。虚弱与短期死亡率增加（OR: 1.79, 95% CI: 1.36-2.35, p < 0.001; I2 = 72%）和功能预后不良（OR: 1.75, 95% CI: 1.33-2.30, p < 0.001; I2 = 67%）显著相关。对死亡率结果进行了亚组分析，并证实了不同患者人口统计学、虚弱评估工具和随访时间之间的一致关联（亚组差异p均为0.05）。通过一次排除一项研究的敏感性分析显示类似的结果（p均<； 0.05），这证明了稳健性。结论：我们的研究表明，虚弱可能与ICrH患者短期死亡风险增加和功能预后不良有关。这些发现强调了脆弱性评估在ICrH患者风险分层和临床决策中的重要性。
{"title":"Frailty and the short-term prognosis of patients with intracranial hemorrhage: A meta-analysis","authors":"Caiyun Li, Fei Xia, Yang Ni, Yiwen Liu","doi":"10.1016/j.jnha.2025.100655","DOIUrl":"10.1016/j.jnha.2025.100655","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is increasingly recognized as a predictor of poor outcomes in acute neurological conditions. However, its impact on the short-term prognosis of patients with intracranial hemorrhage (ICrH) remains unclear. This meta-analysis aimed to evaluate the association between frailty and short-term mortality and functional outcomes in patients with ICrH.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted in PubMed, Embase, and Web of Science from inception to February 10, 2025. Cohort studies evaluating the association between frailty and prognosis in ICrH patients were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model by incorporating the influence of heterogeneity.</div></div><div><h3>Results</h3><div>Twelve cohort studies involving 70,664 patients with ICrH were included. Frailty was significantly associated with increased short-term mortality (OR: 1.79, 95% CI: 1.36–2.35, <em>p</em> < 0.001; I<sup>2</sup> = 72%) and poor functional outcome (OR: 1.75, 95% CI: 1.33–2.30, <em>p</em> < 0.001; I<sup>2</sup> = 67%). Subgroup analyses were performed for mortality outcomes and confirmed consistent associations across different patient demographics, frailty assessment tools, and follow-up durations (<em>p</em> for subgroup difference all >0.05). Sensitivity analyses by excluding one study at a time showed similar results (<em>p</em> all < 0.05), which demonstrated robustness.</div></div><div><h3>Conclusion</h3><div>Our study suggests that frailty may be associated with an increased risk of short-term mortality and poor functional outcomes in patients with ICrH. These findings highlight the importance of frailty assessment in risk stratification and clinical decision-making for ICrH patients.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100655"},"PeriodicalIF":4.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01Epub Date: 2025-08-18DOI: 10.1016/j.jnha.2025.100653
Luping Wang , Jinye Ma , Nanyang Liu , Lina Ma , Hui Pei , Shan He , Hao Li
Background
Loneliness is often accompanied by depression and is associated with an increased risk of dementia. However, evidence remains limited regarding how loneliness and depression jointly relate to future dementia risk, and whether depression may help explain the observed association between loneliness and dementia.
Method
We conducted a study using prospective cohort data from three multinational populations. The association between loneliness, depression, and dementia risk was evaluated using Cox proportional hazards models. Mediation analysis was conducted to evaluate the potential contribution of depression to the observed association between loneliness and dementia risk. Additionally, both multiplicative and additive interaction methods were employed to assess the interaction between loneliness and depression with dementia risk, quantifying their combined associations.
Results
At baseline, a total of 133,388 participants were included in the study. Our study revealed a significant independent association between loneliness or depression and increased dementia risk. Additionally, compared to the group without loneliness or depressive symptoms, the other three groups had significantly higher risks of dementia during follow-up (loneliness only: HR = 1.26, 95% CI: 1.15–1.38; depression only: HR = 1.58, 95% CI: 1.41–1.78; loneliness with depression: HR = 1.98, 95% CI: 1.81–2.17). Mediation analysis showed that depression accounted for 36% of the loneliness-dementia association. Furthermore, we observed a significant additive interaction between loneliness and depression on dementia risk.
Conclusions
This study examined the combined association of loneliness and depression with the risk of developing dementia, underscoring the importance of addressing loneliness and depression as potentially related factors in dementia prevention.
{"title":"Associations of loneliness and depression with increased risks of incident dementia: A prospective study from three older adult cohorts","authors":"Luping Wang , Jinye Ma , Nanyang Liu , Lina Ma , Hui Pei , Shan He , Hao Li","doi":"10.1016/j.jnha.2025.100653","DOIUrl":"10.1016/j.jnha.2025.100653","url":null,"abstract":"<div><h3>Background</h3><div>Loneliness is often accompanied by depression and is associated with an increased risk of dementia. However, evidence remains limited regarding how loneliness and depression jointly relate to future dementia risk, and whether depression may help explain the observed association between loneliness and dementia.</div></div><div><h3>Method</h3><div>We conducted a study using prospective cohort data from three multinational populations. The association between loneliness, depression, and dementia risk was evaluated using Cox proportional hazards models. Mediation analysis was conducted to evaluate the potential contribution of depression to the observed association between loneliness and dementia risk. Additionally, both multiplicative and additive interaction methods were employed to assess the interaction between loneliness and depression with dementia risk, quantifying their combined associations.</div></div><div><h3>Results</h3><div>At baseline, a total of 133,388 participants were included in the study. Our study revealed a significant independent association between loneliness or depression and increased dementia risk. Additionally, compared to the group without loneliness or depressive symptoms, the other three groups had significantly higher risks of dementia during follow-up (loneliness only: HR = 1.26, 95% CI: 1.15–1.38; depression only: HR = 1.58, 95% CI: 1.41–1.78; loneliness with depression: HR = 1.98, 95% CI: 1.81–2.17). Mediation analysis showed that depression accounted for 36% of the loneliness-dementia association. Furthermore, we observed a significant additive interaction between loneliness and depression on dementia risk.</div></div><div><h3>Conclusions</h3><div>This study examined the combined association of loneliness and depression with the risk of developing dementia, underscoring the importance of addressing loneliness and depression as potentially related factors in dementia prevention.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100653"},"PeriodicalIF":4.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01Epub Date: 2025-07-31DOI: 10.1016/j.jnha.2025.100645
Ziyuan Li , Jun Wu , Zhunzhun Liu
Objective
The purpose of this study was to evaluate the feasibility of nutrition education interventions in improving frailty status and dietary quality indicated by the Chinese Healthy Eating Index (CHEI) in frail patients with lung cancer.
Design
A 12-week randomized controlled study on nutrition education in frail patients with lung cancer.
Participants
This study enrolled 56 frail patients with lung cancer (aged ≥60 years) from the Department of Oncology, Affiliated Hospital of Jiangnan University (September 2024-January 2025).
Intervention
Participants were randomly allocated to either the intervention group (n = 28), receiving personalized weekly nutrition education supported by structured dietary interventions that included dietary manuals and site instruction, or the control group (n = 28), which received standard care without additional dietary components.
Main outcome measures
The primary outcomes of this study included frailty scores and prevalence, assessed according to the Fried phenotype criteria, as well as the CHEI score. The Fried phenotype criteria was defined by five components: weight loss, exhaustion, weakness, slowness, and low physical activity. The total score ranges from 0 to 5, with a score of ≥3 indicating frailty. The CHEI score was calculated based on the intake of food categories relative to their standard proportions (SP).
Results
Of the 56 participants, 71.4% were male, with a mean age of 70.6 (SD 4.9). Linear mixed-effects modeling demonstrated that the nutritional intervention group showed significantly lower frailty scores (Effect size = ?'0.642, 95%CI (?'1.017, ?'0.268), P < 0.001) and higher CHEI scores (Effect size = 5.932, 95%CI (1.648, 10.216), P = 0.007), with these effects being independent of temporal variation (time effect: P = 0.347, P = 0.740) and revealed a significant group ?- time interaction for low physical activity scores (Effect size = ?'0.250, 95%CI (?'0.465, ?'0.035), P = 0.023).
Conclusion
In frail lung cancer patients, dietary quality-focused nutrition education improved frailty, nutritional status, and quality of life, offering a safe and promising non-pharmacological strategy for frailty management in this population.
目的评价营养教育干预在改善中国健康饮食指数（CHEI）所指示的虚弱肺癌患者的虚弱状态和饮食质量方面的可行性。设计：虚弱肺癌患者营养教育的12周随机对照研究。研究对象：本研究纳入江南大学附属医院肿瘤科56例（年龄≥60岁）体弱肺癌患者（2024年9月- 2025年1月）。干预参与者被随机分配到干预组（n = 28）和对照组（n = 28），干预组接受个性化的每周营养教育，由结构化的饮食干预支持，包括饮食手册和现场指导，对照组接受标准护理，没有额外的饮食成分。主要结果测量本研究的主要结果包括虚弱评分和患病率，根据Fried表型标准评估，以及CHEI评分。Fried表型标准由五个组成部分定义：体重减轻、疲惫、虚弱、行动迟缓和低体力活动。总分为0 ~ 5分，≥3分为虚弱。CHEI评分是根据食物种类相对于其标准比例（SP）的摄入量计算的。结果56名参与者中，71.4%为男性，平均年龄70.6岁（SD 4.9）。线性混合效应模型显示，营养干预组虚弱评分显著低于对照组(效应值= 0.642,95%CI (1.017, 0.268), P <；0.001)和较高的CHEI得分（效应值= 5.932,95%CI (1.648, 10.216), P = 0.007），且这些效应与时间变化无关（时间效应：P = 0.347, P = 0.740），低体力活动得分存在显著的组-时间交互作用（效应值= 0.250,95%CI (0.465, 0.035), P = 0.023）。结论以饮食质量为中心的营养教育可改善虚弱肺癌患者的虚弱、营养状况和生活质量，为该人群的虚弱管理提供了一种安全、有前景的非药物策略。
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