Journal of Nutrition Health & Aging最新文献

{"title":"Effects of nutritional guidance on frailty in older adults: A systematic review","authors":"Tatsuya Koyama ,&nbsp;Junko Nohara ,&nbsp;Mieko Nakamura","doi":"10.1016/j.jnha.2025.100756","DOIUrl":"10.1016/j.jnha.2025.100756","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is a prevalent geriatric syndrome associated with risk of disability, hospitalization, and mortality. Despite nutrition and exercise playing central roles in maintaining muscle mass and function, the specific effects of nutritional guidance, distinct from supplementation, remain unclear.</div></div><div><h3>Objective</h3><div>This systematic review aimed to evaluate the effectiveness of nutritional guidance interventions on frailty in community-dwelling older adults.</div></div><div><h3>Methods</h3><div>A systematic search in MEDLINE (PubMed) identified relevant randomized controlled trials (RCTs) published up to April 2025. Eligible studies included those with participants aged ≥65 years who received nutritional guidance, defined as dietary counseling or education without supplementation, with frailty status as the primary outcome measure. The risk of bias was assessed using Cochrane RoB 2.0.</div></div><div><h3>Results</h3><div>From 211 initial records, 11 relevant RCTs were included in the analyses. The interventions varied in duration (12 weeks to 8 years), delivery (individual or group sessions), and implementers (dietitians, health professionals, or non-professionals). Short-term interventions produced mixed results, whereas long-term programs, particularly those combined with exercise, showed more consistent improvements in frailty measures. Individually tailored and professionally delivered interventions were generally more effective. However, substantial heterogeneity in intervention design, frailty definitions, and outcome measures limited comparability across studies. Few trials quantitatively assessed dietary intake, restricting mechanistic understanding.</div></div><div><h3>Conclusion</h3><div>Nutritional guidance can help prevent or improve frailty in older adults, especially when implemented as a long-term, individualized, and professionally delivered program, ideally combined with physical activity. Future research should adopt standardized frailty criteria, reliable dietary assessment methods, and multidisciplinary approaches to strengthen the evidence and inform sustainable strategies for healthy aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 1","pages":"Article 100756"},"PeriodicalIF":4.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handgrip strength as a predictor of adverse events in hospitalized older adults: A prospective cohort study","authors":"Giancarlo Sante Farfan ,&nbsp;Roberto Zenteno Zeballos ,&nbsp;Leandro Huayanay Falconi","doi":"10.1016/j.jnha.2025.100746","DOIUrl":"10.1016/j.jnha.2025.100746","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate whether dynapenia at hospital admission predicts adverse events in older adults hospitalized for medical conditions.</div></div><div><h3>Design</h3><div>Prospective observational cohort study. Setting: Hospital Cayetano Heredia, Lima, Peru. Participants: 120 patients aged ≥60 years admitted for medical reasons between July and December 2024. Measurements: Handgrip strength was assessed within 48 h of admission using a JAMAR® dynamometer. Dynapenia was defined as &lt;12 kg in men and &lt;8 kg in women (sex-specific 25th percentile). Participants were followed for 30 days to identify adverse events, including mortality, delirium, readmission, healthcare-associated infections, pressure ulcers, and falls. Cox regression models estimated hazard ratios (HR).</div></div><div><h3>Results</h3><div>Median age was 74 years; 49.2% were women. Dynapenia was present in 30% of participants. During follow-up, 45 adverse events were documented: mortality (12.5%), delirium (9.2%), readmission (5.8%), and others (7.4%). Patients with dynapenia had a higher incidence of adverse outcomes (41.7% vs. 16.7%, p &lt; 0.05). Dynapenia was independently associated with adverse events (adjusted HR 2.32; 95% CI: 1.08–4.99). Sensitivity analyses using intrapopulation tertiles and EWGSOP2 thresholds yielded consistent associations.</div></div><div><h3>Conclusion</h3><div>Dynapenia at admission is an independent predictor of adverse events in hospitalized older adults. Handgrip strength is a simple bedside tool that may improve early risk stratification and support targeted preventive interventions.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 1","pages":"Article 100746"},"PeriodicalIF":4.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary manganese, type 2 diabetes, and cardiovascular disease: A UK Biobank cohort study and meta-analysis of over 270,000 individuals","authors":"Gebretsadkan Gebremedhin Gebretsadik ,&nbsp;Bo Yang ,&nbsp;Andrea J. Glenn ,&nbsp;Ai-Min Yang ,&nbsp;Jie Li ,&nbsp;Vicky Wai-Ki Chan ,&nbsp;Man-Sau Wong ,&nbsp;Simin Liu ,&nbsp;Ka-Hei Kenneth Lo","doi":"10.1016/j.jnha.2025.100754","DOIUrl":"10.1016/j.jnha.2025.100754","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the association of dietary Manganese (Mn) intake with type 2 diabetes (T2D) incidence, total cardiovascular disease (CVD), and CVD mortality by analyzing data from the UK Biobank and conducting a meta-analysis of available prospective cohorts.</div></div><div><h3>Design</h3><div>Prospective analysis of a primary cohort with a dose-response meta-analysis of prospective cohorts.</div></div><div><h3>Setting</h3><div>The UK Biobank cohort and the meta-analysis of prospective cohorts.</div></div><div><h3>Participants</h3><div>UK Biobank participants aged 40–69 years at baseline were enrolled between 2006 and 2010 and followed until December 2022. We included 165,194 participants in T2D analytic cohort and 164,111 individuals in CVD analytic cohort. Our systematic review and meta-analysis of six studies comprised over 270,000 participants.</div></div><div><h3>Exposure</h3><div>Dietary manganese (Mn) intake.</div></div><div><h3>Measurements</h3><div>The outcome measurements were T2D incidence, total CVD, and CVD mortality. Dietary intake was assessed using 24-h dietary instrument. Cox proportional hazards models were used to assess associations of Mn intake with T2D and CVD risk. Effect estimates were presented in hazard ratios (HR) with 95% confidence intervals (CI). In meta-analysis, a pooled risk for a 1 mg/day increase in Mn intake was estimated using restricted maximum likelihood (REML).</div></div><div><h3>Results</h3><div>High Mn intake (Q5) was not significantly associated with lower risk of T2D as compared to Q1 (adjusted HR 0·91; 95% CI 0·82, 1.01, P_trend = 0·07). The dose-response meta-analysis revealed a 4% reduction in T2D risk with each mg/day increase in Mn intake (pooled RR 0·96; 95% CI 0·94, 0·99), with potential non-linearity (P_nonlinear&lt; 0.01). Q5 Mn intake was not significantly associated with reduced risk of CVD (adjusted HR 0·99; 95% CI 0·92, 1.05; <em>P_trend</em> = 0·61) or CVD mortality (adjusted HR 0·85; 95% CI 0·64, 1.13; <em>P_trend</em> = 0·66).</div></div><div><h3>Conclusions</h3><div>Our meta-analysis suggested that increasing Mn intake may lower T2D risk, potentially exhibiting a dose-response non-linear pattern, although not corroborated by UK Biobank analysis.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 2","pages":"Article 100754"},"PeriodicalIF":4.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145711919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do the effects of krill oil supplementation on skeletal muscle function and size in older adults differ by sex, age or BMI: A secondary analysis of a randomised controlled trial","authors":"Oliver Hayman ,&nbsp;Saleh AA Alkhedhairi ,&nbsp;Emile Combet ,&nbsp;Terry J Quinn ,&nbsp;Angus M Hunter ,&nbsp;Stuart Goodall ,&nbsp;Stuart R. Gray","doi":"10.1016/j.jnha.2025.100747","DOIUrl":"10.1016/j.jnha.2025.100747","url":null,"abstract":"<div><div>This study examined whether the effects of krill oil supplementation on muscle function and size differ by sex, age or BMI in healthy older adults. This was a secondary exploratory analysis of a previous randomised controlled trial. Men and women aged ≥65 years, with BMI &lt; 35 kg/m² and engaging in &lt;1 h per week of structured exercise, were enrolled in a randomised, double-blind, controlled trial (NCT04048096) between March 2018 and March 2020. Participants received either 4 g/day krill oil or a control oil for 6 months. Ninety-four participants were included (Control n = 45; 27 women, 18 men; Krill n = 49; 26 women, 23 men) with muscle size, strength and neuromuscular function measured before and after the intervention period. Responses to intervention were compared between subgroups by sex (male/female), age (≤70 years/&gt;70 years) and BMI (≤24.9 kg/m²/&gt;25 kg/m²). Increases in muscle strength, size, and physical function in response to krill oil supplementation were comparable across age, sex and BMI subgroups (all P &gt; 0.05). This was similar for neuromuscular measures although increases in the Mwave the response to krill oil supplementation differed by sex, with no change over time in females in either krill or control groups, but an increase in Mwave in males in the krill group (+3.80 [1.72–5.88] mV, p = 0.016) with a tendency for a decrease in the control group (−3.71 [1.58–6.05] mV, p = 0.059). In conclusion, krill oil supplementation improved muscle strength and size in older adults regardless of age, sex and BMI status, although neuromuscular effects of krill oil on membrane excitability, via the Mwave, may be more pronounced in men.</div><div>ClinicalTrials.gov Identifier: NCT04048096</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 1","pages":"Article 100747"},"PeriodicalIF":4.0,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalizability concerns in the vitamin D and sarcopenia link","authors":"Yi Zou,&nbsp;Qi Yang,&nbsp;Xiping Wang,&nbsp;Xiaokun Tang,&nbsp;Mei Yang","doi":"10.1016/j.jnha.2025.100741","DOIUrl":"10.1016/j.jnha.2025.100741","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 1","pages":"Article 100741"},"PeriodicalIF":4.0,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor concerning “Association between cMIND diet adherence and frailty among Chinese older adults: A 10-year longitudinal study”","authors":"Lin Yang,&nbsp;Jing Shu","doi":"10.1016/j.jnha.2025.100742","DOIUrl":"10.1016/j.jnha.2025.100742","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 1","pages":"Article 100742"},"PeriodicalIF":4.0,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor concerning ‘Association between cMIND diet adherence and frailty among Chinese older adults: A 10-year longitudinal study’","authors":"Yu Qiu ,&nbsp;Longqing Yu","doi":"10.1016/j.jnha.2025.100743","DOIUrl":"10.1016/j.jnha.2025.100743","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 1","pages":"Article 100743"},"PeriodicalIF":4.0,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Individual Beverage Types and Substitution with Dementia Risk: A UK Biobank Cohort Study","authors":"Jung-Hwan Kim ,&nbsp;Yu-Jin Kwon ,&nbsp;Yaeji Lee ,&nbsp;Taehwa Han ,&nbsp;Mi Young Lim ,&nbsp;Seok-Jae Heo ,&nbsp;Ji-Won Lee","doi":"10.1016/j.jnha.2025.100740","DOIUrl":"10.1016/j.jnha.2025.100740","url":null,"abstract":"<div><h3>Objectives</h3><div>The role of beverage consumption in dementia prevention, particularly regarding substitution effects and interactions with modifiable risk factors, remains unclear. This study aimed to evaluate the associations of major beverage types and their substitution effects with the risk of all-cause dementia.</div></div><div><h3>Design</h3><div>A prospective cohort study.</div></div><div><h3>Setting and participants</h3><div>We included 118,963 dementia-free participants (2006–2010 baseline) with complete dietary questionnaires from the UK Biobank.</div></div><div><h3>Measurements</h3><div>Self-reported intake of sugar-sweetened beverages, artificially sweetened beverages, natural juices, coffee, and tea was assessed through 24-h dietary recall. The primary outcome was incident all-cause dementia, ascertained through linked primary care, hospital admission, and mortality registration data. Associations between beverage intake and dementia risk were evaluated using Cox proportional hazards models, yielding hazard ratios (HRs) and 95% confidence intervals (CIs). Substitution modeling assessed the effects of replacing one beverage with another. Interaction analyses explored variations by modifiable risk factors, including obesity, hypertension, depression, or dyslipidemia.</div></div><div><h3>Results</h3><div>Over 13.45 years, 992 all-cause dementia cases were recorded. Higher sugar-sweetened beverage intake (&gt;1 glass/day) was associated with an increased risk of all-cause dementia (HR, 1.61; 95% CI, 1.28–2.02; <em>P</em> &lt; 0.001). Coffee and tea consumption were associated with a lower risk of all-cause dementia. Substituting sugar-sweetened beverages or artificially sweetened beverages with coffee or tea significantly reduced the risk of all-cause dementia. These protective associations were strongest among individuals with obesity, hypertension, depression, or dyslipidemia.</div></div><div><h3>Conclusion</h3><div>Replacing sugar-sweetened beverages or artificially sweetened beverages with coffee or tea was associated with a reduced risk of dementia, particularly among individuals with modifiable risk factors. These findings support beverage substitution as a simple, targeted strategy for mitigating the risk of dementia.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 1","pages":"Article 100740"},"PeriodicalIF":4.0,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential causes of malnutrition in older adults in primary healthcare—A cross-sectional study","authors":"Stefan Pfannkuch ,&nbsp;Rainer Wirth ,&nbsp;Ulrike Trampisch ,&nbsp;Dorothee Volkert ,&nbsp;Maryam Pourhassan","doi":"10.1016/j.jnha.2025.100745","DOIUrl":"10.1016/j.jnha.2025.100745","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the prevalence of the Determinants of Malnutrition in Aged Persons (DoMAP) and identify determinants of malnutrition among older adults attending primary healthcare.</div></div><div><h3>Design and setting</h3><div>Prospective, observational, monocentric study in primary healthcare.</div></div><div><h3>Participants</h3><div>500 older adults.</div></div><div><h3>Measurements</h3><div>Malnutrition was diagnosed using the Global Leadership Initiative on Malnutrition (GLIM) criteria. Potential causes of malnutrition were assessed by the attending physician using the DoMAP model with a 1:1 recruitment of malnourished and non-malnourished older persons.</div></div><div><h3>Results</h3><div>Malnourished individuals (mean age 81.7 ± 5.0 years; 59% women) exhibited a significantly higher prevalence of almost all DoMAP determinants compared to non-malnourished persons, particularly low intake (88 vs. 11%), high requirements (83 vs. 49%), poor appetite (73 vs. 9%), shopping difficulties (59 vs. 26%), inflammation (81 vs. 49%), gastrointestinal disease (17 vs. 2%), cancer (11 vs. 1%), depression (35 vs. 19%), dementia (21 vs. 6%), polypharmacy (60 vs. 38%), and hospitalization (27 vs. 4%). The mean total determinants count was significantly higher in malnourished participants (14.9 ± 5.0) than in non-malnourished ones (6.8 ± 4.4; <em>p</em> &lt; 0.001). Regression analysis revealed low intake as the strongest determinant at Level1; poor appetite, forgetting to eat, shopping difficulties and inflammation at Level2; gastrointestinal disease, cancer and depression at Level3, and frailty and hospitalization at Level4.</div></div><div><h3>Conclusion</h3><div>This study highlights the complex multifactorial nature of malnutrition in older adults attending primary healthcare, confirming the superior role of low intake and poor appetite among other determinants. The DoMAP model offers a structured framework for potential causative factors of malnutrition in older subjects.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 1","pages":"Article 100745"},"PeriodicalIF":4.0,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Omega-3 Supplement Use and Cognitive Function in Korean Older Adults: An 8-Year Longitudinal Cohort Study","authors":"Won Man Lee ,&nbsp;So Im Ryu ,&nbsp;Myoung-Nam Lim ,&nbsp;Ji Won Han ,&nbsp;Jong Bin Bae ,&nbsp;Tae Hui Kim ,&nbsp;Kyung Phil Kwak ,&nbsp;Bong Jo Kim ,&nbsp;Shin Gyeom Kim ,&nbsp;Jeong Lan Kim ,&nbsp;Seok Woo Moon ,&nbsp;Joon Hyuk Park ,&nbsp;Seung-Ho Ryu ,&nbsp;Dong Woo Lee ,&nbsp;Seok Bum Lee ,&nbsp;Jung Jae Lee ,&nbsp;Dong Young Lee ,&nbsp;Ki Woong Kim ,&nbsp;Jin Hyeong Jhoo","doi":"10.1016/j.jnha.2025.100739","DOIUrl":"10.1016/j.jnha.2025.100739","url":null,"abstract":"<div><h3>Objectives</h3><div>South Korea has a relatively high baseline omega-3 fatty acids (O3FA) status due to dietary patterns. However, evidence on additional benefits of O3FA supplementation remains limited. This study examined the 8-year longitudinal effects of O3FA supplement use on cognitive performance among community-dwelling older adults in South Korea.</div></div><div><h3>Design</h3><div>Prospective longitudinal cohort study.</div><div>Setting and participants: Data were from the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD). A total of 4,949 adults aged ≥60 years (mean age = 69.55 ± 6.56; 44.2% men) were included, and 2,053 completed the 8-year follow-up (2010–2012 to 2018–2020).</div></div><div><h3>Measurements</h3><div>O3FA supplement use was assessed through structured questionnaires on regular intake of omega-3 or fish oil supplements. Cognitive performance was assessed using the Korean version of Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet Neuropsychological Assessment Battery (CERAD-K[N]), and total and memory domain scores were analyzed. Longitudinal changes were examined using repeated measures analysis of covariance and linear mixed-effects models (LMMs; unweighted and weighted), adjusting for potential covariates.</div></div><div><h3>Results</h3><div>Over the 8 years, CERAD-K[N] (t = −2.686, p = .007) and memory domain (t = −4.026, p &lt; .001) scores significantly improved among O3FA users. In the weighted LMM, significant time × supplement duration interactions were observed (CERAD-K[N]: β = 2.398, 95% CI 1.207–3.589, p &lt; .001; memory: β = 1.050, 95% CI 0.643–1.456, p &lt; .001), indicating greater improvement in long-term users.</div></div><div><h3>Conclusion</h3><div>O3FA supplement use was associated with better maintenance of cognitive function over eight years. These findings suggest a potential role of O3FA supplementation in supporting cognitive health during aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 1","pages":"Article 100739"},"PeriodicalIF":4.0,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}