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Sarcopenic obesity is associated with cardiometabolic multimorbidity in Chinese middle-aged and older adults: a cross-sectional and longitudinal study 中国中老年人肌肉松弛性肥胖与心脏代谢多病相关:一项横断面和纵向研究
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-07 DOI: 10.1016/j.jnha.2024.100353
Bingyan Yu , Shize Jia , Tiantian Sun , Jieliang Liu , Junguo Jin , Shanghong Zhang , Qiyao Xiao , Haojian Dong , Yanqiu Ou

Objectives

Sarcopenic obesity (SO) has been found to increase the risk of metabolic disorders, however, its relationship with cardiometabolic multimorbidity (CMM) remains unexplored. This study aims to investigate the potential association between SO and CMM in the middle-aged and older population.

Methods

Our study subjects were from CHARLS. SO was defined as the combination of impaired grip strength (grip strength <28 kg for men and <18 kg for women) and increased body mass index (BMI ≥25 kg/m2). CMM was defined as having two or more cardiometabolic diseases, including diabetes mellitus, stroke, and heart disease. The participants were divided into four groups according to their sarcopenia and obesity status, and logistic regression analysis was used to examine the association between SO and CMM.

Results

A total of 15,252 study subjects were included in the cross-sectional study, with an average age of 60.6 years and a male proportion of 47.4%. In the cross-sectional analysis conducted in 2015, the prevalence of CMM was highest in the SO group (9.1%), followed by the obesity (3.7%) and sarcopenia (3.5%) group. After adjustment for confounding factors, SO [OR (95%CI): 2.453 (1.742−3.455)], sarcopenia [OR (95% CI): 1.601 (1.157−2.217)], obesity [OR (95% CI): 1.446 (1.107−1.888)] were all observed to be associated with CMM, with the strongest association in the SO group. Furthermore, in the longitudinal analysis, only the SO group demonstrated a significant risk for developing CMM [OR (95% CI): 2.302 (1.239−4.228)].

Conclusions

SO was independently and positively associated with CMM in middle-aged and older population.

研究发现,肌肉松弛性肥胖(SO)会增加代谢紊乱的风险,但其与心脏代谢多病症(CMM)之间的关系仍未得到探讨。本研究旨在调查中老年人群中肥胖症与 CMM 之间的潜在关联。SO定义为握力受损(男性握力为28公斤,女性握力为18公斤)和体重指数增加(BMI≥25 kg/m2)。CMM的定义是患有两种或两种以上的心脏代谢疾病,包括糖尿病、中风和心脏病。根据参与者的肌少症和肥胖状况将其分为四组,并采用逻辑回归分析法研究肌少症与 CMM 之间的关系。结果共有 15 252 名研究对象参与了横断面研究,平均年龄为 60.6 岁,男性比例为 47.4%。在2015年进行的横断面分析中,SO组的CMM发病率最高(9.1%),其次是肥胖组(3.7%)和肌肉疏松组(3.5%)。在对混杂因素进行调整后,观察到SO组[OR(95%CI):2.453(1.742-3.455)]、肌肉疏松组[OR(95%CI):1.601(1.157-2.217)]、肥胖组[OR(95%CI):1.446(1.107-1.888)]均与CMM相关,其中SO组的相关性最强。此外,在纵向分析中,只有SO组显示出罹患CMM的显著风险[OR(95% CI):2.302(1.239-4.228)]。
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引用次数: 0
Association of novel anthropometric indices with all-cause mortality in hypertensive patients: Evidence from NHANES 2007–2018 新型人体测量指数与高血压患者全因死亡率的关系:来自 2007-2018 年国家健康调查(NHANES)的证据
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-07 DOI: 10.1016/j.jnha.2024.100356
Shanshan Jia , Lu Liu , Xingwei Huo, Lirong Sun, Xiaoping Chen
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引用次数: 0
The association between weight-adjusted waist index and frailty defined by Fried's Frailty Phenotype among Chinese people 中国人体重调整后腰围指数与弗里德虚弱表型所定义的虚弱之间的关系。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-05 DOI: 10.1016/j.jnha.2024.100350
Xiao-Ming Zhang , Lihuan Chen , Xin You , Aizhang Zhu , Jiang Wang , Rui Zeng , Fayi Xie , Dongmei Ye , Wan Zhu , Ke Zhu , Tenghui Fan , Yunzhi Yang , Wen-wu Zhang , Conghua Wang
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引用次数: 0
The relationship between mineral mixture intake and cognitive function in older US adults: a cross-sectional NHANES study 美国老年人矿物质混合物摄入量与认知功能之间的关系:一项横断面 NHANES 研究。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-05 DOI: 10.1016/j.jnha.2024.100355
Yan Zhuang , Laifu Li , Yanqi Zhang , Fei Dai , Jingyan Sun
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引用次数: 0
Integrating precision health with multidomain interventions to advance strategies for healthy aging 将精准健康与多领域干预相结合,推进健康老龄化战略。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-05 DOI: 10.1016/j.jnha.2024.100354
Liang-Kung Chen
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引用次数: 0
Analysis of combinatory effects of free weight resistance training and a high-protein diet on body composition and strength capacity in postmenopausal women - A 12-week randomized controlled trial 分析自由重量阻力训练和高蛋白饮食对绝经后妇女身体成分和力量能力的综合影响 - 一项为期 12 周的随机对照试验
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-03 DOI: 10.1016/j.jnha.2024.100349
Paulina Ioannidou , Zsuzsanna Dóró , Jan Schalla , Wim Wätjen , Patrick Diel , Eduard Isenmann

Background

Menopause has a significant impact on the endocrine system of middle-aged women, resulting in a loss of skeletal muscle mass (SMM), changes in fat mass (FM) and a reduction in strength capacity. Resistance training (RT) and a high-protein diet (HPD) are effective methods for maintaining or increasing SMM. This study aims to determine the effects of HPD and RT on body composition, muscle thickness and strength capacity in postmenopausal women.

Methods

In total 55 healthy postmenopausal women (age: 58.2 ± 5.6 years, weight 69.1 ± 9.6 kg, height 166.5 ± 6.5 cm) successfully participated in the study. The women were randomly assigned to either group: training + protein (2.5 g/kg fat-free mass (FFM)) (n = 15; TP); only training (n = 12; T); only protein (2.5 g/kg FFM) (n = 14; CP) or control (n = 14; C). TP and T performed RT for 12 weeks with three training sessions and five exercises each. CP and C were prohibited from training during the period. The main parameters analysed for body composition were FFM, SMM, FM, muscle thickness of the M. rectus femoris, M. biceps femoris, M. triceps brachii and M. biceps brachii muscles. Strength was tested using a dynamometer for grip strength and 1-RM in the squat (BBS) and deadlift (DL).

Results

The SMM significantly increased by RT (TP: (Δ+1.4 ± 0.9 kg; p < 0.05; d = 0.4; T: Δ+1.2 ± 1.3kg; p < 0.05; d = 0.3) and FM could be reduced only in T: (Δ−2.4 ± 2.9 kg; p < 0.05; d = 0.3). In muscle thickness a significant increase in the M. biceps brachii in both training groups (TP: (Δ+0.4 ± 0.3 cm; p < 0.05; d = 1.6; T: (Δ+0.3 ± 0.3 cm; p < 0.05; d = 0.9) and in M. biceps femoris only in TP (Δ+0.3 ± 0.4 cm; p < 0.05; d = 0.9) were observed. HPD without training does not affect body composition, A significant increase in grip strength (TP: Δ+4.7 ± 2.4 kg; (p < 0.05; d = 1.5; T: (Δ+3.6 ± 3.0 kg; p < 0.05; d = 0.8), in BBS (TP: (Δ+30.0 ± 14.2 kg; p < 0.05; d = 1.5; T: (Δ+34.0 ± 12.0 kg; p < 0.05; d = 2.4) and in DL (TP: (Δ+20.8 ± 10.3 kg; p < 0.05; d = 1.6; T: (Δ+22.1 ± 7.6 kg; p < 0.05; d = 2.0) was observed in both training groups. The CP also recorded a significant increase in the BBS (Δ+7.5 ± 5.4 kg; p < 0.05; d = 0.4) and in DL (Δ+5.5 ± 7.7 kg; p < 0.05; d = 0.5). No significant differences were detected for TP and T for any of the parameters.

Conclusion

The results indicate that RT enhances body composition and strength capacity in postmenopausal women and is a preventive strategy against muscle atrophy. Besides HPD without training has a trivial significant effect on BBS and DL. HPD with RT has no clear additive effect on body composition and strength capacity. Further studies are needed to confirm these observations.

背景绝经对中年女性的内分泌系统有重大影响,导致骨骼肌质量(SMM)减少、脂肪量(FM)变化和力量能力下降。阻力训练(RT)和高蛋白饮食(HPD)是维持或增加骨骼肌质量的有效方法。本研究旨在确定 HPD 和 RT 对绝经后妇女的身体成分、肌肉厚度和力量能力的影响。方法共有 55 名健康的绝经后妇女(年龄:58.2 ± 5.6 岁,体重 69.1 ± 9.6 公斤,身高 166.5 ± 6.5 厘米)成功参与了本研究。这些妇女被随机分配到以下任一组:训练+蛋白质(2.5 克/千克无脂质量(FFM))(n = 15;TP);仅训练(n = 12;T);仅蛋白质(2.5 克/千克无脂质量(FFM))(n = 14;CP)或对照组(n = 14;C)。TP和T进行了为期12周的RT训练,各进行了三次训练和五次练习。CP 和 C 在此期间禁止训练。身体成分分析的主要参数包括 FFM、SMM、FM,以及股直肌、股二头肌、肱三头肌和肱二头肌的肌肉厚度。使用测力计测试握力以及深蹲(BBS)和负重举(DL)的 1-RM 力量。4 ± 0.9 kg; p < 0.05; d = 0.4; T: Δ+1.2 ± 1.3 kg; p < 0.05; d = 0.3),而 FM 仅在 T: (Δ-2.4 ± 2.9 kg; p < 0.05; d = 0.3) 时才会减少。在肌肉厚度方面,两个训练组的肱二头肌(TP:(Δ+0.4 ± 0.3 cm; p < 0.05; d = 1.6;T:(Δ+0.3 ± 0.3 cm; p < 0.05; d = 0.9)和股二头肌(TP:(Δ+0.3 ± 0.4 cm; p < 0.05; d = 0.9)都有明显增加。不进行训练的 HPD 不会影响身体成分,但握力(TP:Δ+4.7 ± 2.4 kg;p <;0.05;d = 1.5;T:Δ+3.6 ± 3.0 kg;p <;0.05;d = 0.8)、BBS(TP:Δ+30.0 ± 14.2 kg; p < 0.05; d = 1.5; T: (Δ+34.0 ± 12.0 kg; p < 0.05; d = 2.4)和 DL (TP: (Δ+20.8 ± 10.3 kg; p < 0.05; d = 1.6; T: (Δ+22.1 ± 7.6 kg; p < 0.05; d = 2.0)中都观察到。CP组的BBS(Δ+7.5 ± 5.4 kg;p <;0.05;d = 0.4)和DL(Δ+5.5 ± 7.7 kg;p <;0.05;d = 0.5)也有明显增加。结果表明,RT 可增强绝经后妇女的身体成分和力量能力,是预防肌肉萎缩的一种策略。此外,不进行训练的 HPD 对 BBS 和 DL 的影响微不足道。HPD 和 RT 对身体成分和力量能力没有明显的叠加效应。要证实这些观察结果,还需要进一步的研究。
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引用次数: 0
Breastfeeding in infancy and cardiovascular disease in middle-aged and older adulthood: a prospective study of 0.36 million UK Biobank participants 婴儿期母乳喂养与中老年心血管疾病:对 0.36 万英国生物数据库参与者的前瞻性研究
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-08-30 DOI: 10.1016/j.jnha.2024.100347
Shanshan Li , Xiaoyan Wang , Xinmei Li , Weiwei Zhang , Yingying Guo , Nuo Xu , Junkai Luo , Shankuan Zhu , Wei He

Background

Cardiovascular disease originates in early life. We aimed to investigate the association between breastfeeding in infancy and cardiovascular disease in adult life.

Methods

We followed 364,240 participants from UK Biobank aged 40–73 years from 2006 – 2010 to 2021. Information on breastfeeding in infancy was self-reported by questionnaire. Cox proportional hazard regression models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for the association between breastfeeding and cardiovascular disease in middle-aged and older adulthood. The multivariable Cox models were used by adjusting for the age (used as the time scale), sex, ethnicity, assessment centre, birth weight, multiple birth status, maternal smoking during pregnancy, Townsend deprivation index, smoking status, alcohol drinker status, physical activity, and menopausal status for women. Binary and multinomial multivariable logistic regression models were used to explore the associations of breastfeeding in infancy with cardiovascular disease risk factors including obesity, body composition, metabolic and inflammatory disorders.

Results

During a median of 12.6 years of follow-up, we documented 29,796 new cases of cardiovascular disease, including 24,797 coronary heart disease and 6229 stroke. The multivariable adjusted HRs for breastfed versus non-breastfed were 0.94 (95% CI: 0.91, 0.96) for cardiovascular disease, 0.94 (95% CI: 0.91, 0.96) for coronary heart disease, and 0.95 (95% CI: 0.89, 1.01) for stroke. Furthermore, the strength of observed association between breastfeeding and cardiovascular disease seems to decrease with age (P for interaction <0.001), and increase with polygenic risk for cardiovascular disease (P for interaction <0.001). Consistently, breastfeeding in infancy was associated with cardiovascular disease risk factors including lower body mass index 0.92 (95% CI: 0.89, 0.95), body fat percentage 0.85 (95% CI: 0.83, 0.87), android to gynoid fat ratio 0.89 (95% CI: 0.83, 0.96), visceral adipose tissue 0.92 (95% CI: 0.84, 1.01), as well as lower C-reactive protein level 0.95 (95% CI: 0.94, 0.97) and a lower risk of metabolic syndrome 0.89 (95% CI: 0.85, 0.92).

Conclusions

Breastfeeding in infancy was associated with a lower risk of cardiovascular disease in middle-aged and older adulthood. Promoting breastfeeding is vital not only for promoting child health, but also for halting the increasing trend of cardiovascular disease in adults.

背景心血管疾病起源于生命早期。我们的目的是调查婴儿期母乳喂养与成年后心血管疾病之间的关系。方法我们对英国生物库中年龄在 40-73 岁之间的 364 240 名参与者进行了跟踪调查,调查时间从 2006 年至 2010 年,直至 2021 年。关于婴儿期母乳喂养的信息是通过问卷调查自我报告的。我们使用 Cox 比例危险回归模型来估算母乳喂养与中老年心血管疾病之间关系的危险比 (HR) 和 95% 置信区间 (CI)。使用多变量 Cox 模型时,对年龄(作为时间尺度)、性别、种族、评估中心、出生体重、多胎妊娠状况、孕期吸烟、汤森贫困指数、吸烟状况、饮酒状况、体力活动和女性更年期状况进行了调整。结果在中位数为 12.6 年的随访期间,我们记录了 29796 例心血管疾病新发病例,其中包括 24797 例冠心病和 6229 例中风。母乳喂养与非母乳喂养的多变量调整 HR 值分别为:心血管疾病 0.94(95% CI:0.91,0.96),冠心病 0.94(95% CI:0.91,0.96),中风 0.95(95% CI:0.89,1.01)。此外,观察到的母乳喂养与心血管疾病之间的关联强度似乎随着年龄的增长而降低(交互作用的 P 值为 0.001),并随着心血管疾病多基因风险的增加而升高(交互作用的 P 值为 0.001)。一致的是,婴儿期母乳喂养与心血管疾病风险因素相关,包括较低的体重指数 0.92 (95% CI: 0.89, 0.95)、体脂百分比 0.85 (95% CI: 0.83, 0.87)、甲状腺与雌性脂肪比率 0.89 (95% CI: 0.83, 0.96)、内脏脂肪组织 0.92(95% CI:0.84,1.01),以及较低的 C 反应蛋白水平 0.95(95% CI:0.94,0.97)和较低的代谢综合征风险 0.89(95% CI:0.85,0.92)。推广母乳喂养不仅对促进儿童健康至关重要,而且对遏制成人心血管疾病的增长趋势也至关重要。
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引用次数: 0
Letter to the Editor regarding “The Role of Sarcopenia in Overactive Bladder in Adults in the United States: Retrospective Analysis of NHANES 2011–2018” 致编辑的信,内容涉及 "膀胱过度活动症在美国成年人中的作用:2011-2018年NHANES回顾性分析"
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-08-29 DOI: 10.1016/j.jnha.2024.100348
Dieying Jiang , Jianyang Luo
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引用次数: 0
Adherence to resistance training and hypocaloric diet among persons near retirement age — A secondary data analysis of three randomized controlled trials 接近退休年龄的人坚持阻力训练和低热量饮食--对三项随机对照试验的二手数据分析
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-08-26 DOI: 10.1016/j.jnha.2024.100344
S. Bauer , L. Reiter , P.J.M. Weijs , J.D. Schoufour , Y. Boirie , E. Topinková , R.G. Memelink , A.M. Verreijen , A. Borenich , D. Eglseer , the SO-NUTS consortium

Objectives

Adherence to lifestyle interventions is crucial for the treatment of obesity. However, there is little research about adherence to lifestyle interventions in persons around retirement age. The objectives of this study are (1) to identify factors associated with the adherence to resistance training and a hypocaloric diet and (2) to describe the association between adherence and changes in body composition outcome parameters.

Design

This secondary data analysis included three randomized controlled trials.

Setting & participants

The inclusion criteria of the participants were an age of 55–75 years, a BMI ≥ 25 kg/m2 and receiving both a hypocaloric diet and resistance training. All participants were residing in the community.

Measurements

Adherence to hypocaloric diet was measured through the mean dietary intake on the basis of a 3-day dietary record. If the participant consumed at least 600 kcal less than the individual caloric requirements, they were considered adherent. Adherence to resistance training was achieved if ≥67% of the recommended training sessions were attended over the course of the study periods.

Results

232 participants were included, 47.0% female, mean age 64.0 (±5.5) years. 80.2% adhered to resistance training and 51.3% adhered to a hypocaloric diet. Older age (Beta 0.41; 95% CI 0.05, 0.78; p = 0.028) and male sex (Beta 7.7; 95% CI 3.6, 11; p < 0.001) were associated with higher resistance training adherence. A higher BMI at baseline (Beta 6.4; 95% CI 3.6, 9.2; p < 0.001) and male sex (Beta 65; 95% CI 41, 88; p < 0.001) were associated with higher adherence to hypocaloric diet.

Conclusion

We identified several associated factors (sex, age and BMI at baseline) that should be considered to promote adherence in future lifestyle intervention studies in persons around retirement age. We recommend including behavior change techniques in lifestyle interventions and consider sex-specific interventions to improve the adherence of women.

目标坚持生活方式干预对治疗肥胖症至关重要。然而,有关退休人员坚持生活方式干预的研究却很少。本研究的目的是:(1)确定与坚持阻力训练和低热量饮食相关的因素;(2)描述坚持阻力训练与身体成分结果参数变化之间的关系。测量低热量饮食的依从性根据 3 天饮食记录的平均饮食摄入量进行测量。如果参与者摄入的热量比个人热量需求至少少 600 千卡,则被视为坚持低热量饮食。如果在研究期间参加了≥67%的推荐训练课程,则视为坚持了阻力训练。结果232名参与者中,47.0%为女性,平均年龄为64.0(±5.5)岁。80.2%的参与者坚持阻力训练,51.3%的参与者坚持低热量饮食。年龄越大(Beta 0.41; 95% CI 0.05, 0.78; p = 0.028)、性别为男性(Beta 7.7; 95% CI 3.6, 11; p <0.001),坚持阻力训练的比例越高。基线体重指数(BMI)较高(Beta 6.4;95% CI 3.6,9.2;p <;0.001)和男性(Beta 65;95% CI 41,88;p <;0.001)与低热量饮食坚持率较高相关。我们建议在生活方式干预中加入行为改变技术,并考虑针对不同性别的干预措施,以提高女性的坚持率。
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引用次数: 0
Sex differences in the association between social frailty and diet quality among older adults in Spain 西班牙老年人社会脆弱性与饮食质量之间的性别差异
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-08-26 DOI: 10.1016/j.jnha.2024.100346
Lucía Carcedo-Argüelles , Sara Llamas-Fernández , María del Mar Fernández-Álvarez , Francisco Félix Caballero-Díaz , Fernando Rodríguez-Artalejo , Esther López-García , Alberto Lana

Objective

The aim was to examine the association between social frailty and diet quality in adults over 65 years of age, and whether results differed by sex.

Design

Population-based cross-sectional study using data from the Spanish National Health Survey.

Participants

5,071 community-dwelling people ≥65 years from Spain.

Measurements

Social frailty was deemed to exist when the person both lived alone and had low social support, measured with the Duke-UNC scale. Diet was assessed with the Spanish Healthy Eating Index (S-HEI), ranging from 0 to 100 points (highest diet quality). Means and 95% confidence intervals of the S-HEI score for each social frailty group were calculated using linear regressions, with socially robust people as reference. Analyses were adjusted for main confounders, including sociodemographic, lifestyle and morbidity variables.

Results

There were no differences in the S-HEI adjusted mean of socially frail (74.3 points, 95%CI: 73.4−75.2) compared to socially robust older adults (75.4 points; 95%CI: 75.1−75.7). In sex-stratified analyses, the S-HEI adjusted mean of socially frail men (71.9 points; 95%CI: 70.6−73.2) was lower than robust men (74.8 points; 95%CI: 74.4−75.3). Specifically, social frailty was associated with lower consumption of vegetables, fruits, dairy and lower diet variety in men. Differences were not observed according to social frailty among older women.

Conclusions

Social frailty was associated with poor diet quality in community-dwelling older men, but not in women in Spain. Gender differences in self-care could partly explain this association. Sex-specific interventions are required to minimize the impact of social frailty on diet quality.

目的:研究 65 岁以上成年人的社会脆弱性与饮食质量之间的关系,以及不同性别的研究结果是否存在差异。饮食采用西班牙健康饮食指数(S-HEI)进行评估,从 0 分到 100 分不等(饮食质量最高)。以社交能力强的人为参照,通过线性回归计算出每个社交能力弱群体的 S-HEI 分数的平均值和 95% 的置信区间。结果与社交能力强的老年人(75.4 分;95%CI:75.1-75.7)相比,社交能力弱的老年人的 S-HEI 调整后平均值(74.3 分,95%CI:73.4-75.2)没有差异。在性别分层分析中,社交脆弱男性的 S-HEI 调整后平均值(71.9 分;95%CI:70.6-73.2)低于社交稳健男性(74.8 分;95%CI:74.4-75.3)。具体而言,男性的社会脆弱性与蔬菜、水果和奶制品的消费量较低以及饮食种类较少有关。结论在西班牙,社会脆弱性与社区居住的老年男性饮食质量差有关,但与女性无关。自我护理方面的性别差异可以部分解释这种关联。需要采取针对不同性别的干预措施,以尽量减少社会脆弱性对饮食质量的影响。
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引用次数: 0
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Journal of Nutrition Health & Aging
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