Journal of Nutrition Health & Aging最新文献

{"title":"Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study","authors":"Sihan Song ,&nbsp;Joong-Yeon Lim ,&nbsp;Miji Kim ,&nbsp;Chang Won Won ,&nbsp;Hyun-Young Park","doi":"10.1016/j.jnha.2025.100713","DOIUrl":"10.1016/j.jnha.2025.100713","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to explore the association of circulating vitamin D levels with incidence of sarcopenia and its diagnostic components in older men and women.</div></div><div><h3>Design</h3><div>Two-year longitudinal study.</div></div><div><h3>Setting</h3><div>Nationwide Korean Frailty and Aging Cohort Study.</div></div><div><h3>Participants</h3><div>A total of 1,292 adults (53% women) aged 70–84 years without sarcopenia at baseline and who completed the 2-year follow-up sarcopenia assessment were included.</div></div><div><h3>Measurements</h3><div>Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured using a chemiluminescent immunoassay and categorized into sex- and blood collection period-specific quartiles. The appendicular skeletal muscle mass was assessed using dual-energy X-ray absorptiometry. Muscle strength was evaluated using handgrip strength, and physical performance was assessed using the five-times-sit-to-stand test, usual gait speed, and Short Physical Performance Battery. Sarcopenia was defined in accordance with the 2019 consensus of the Asian Working Group for Sarcopenia. Logistic regression and generalized linear models were used to assess the association of serum 25(OH)D concentrations with sarcopenia and its components.</div></div><div><h3>Results</h3><div>Over the 2-year follow-up, incident sarcopenia occurred in 15.7% of men and 12.1% of women. Serum 25(OH)D concentrations were inversely associated with incident sarcopenia in men (odds ratio [OR] for the highest vs. lowest quartile, 0.47; 95% confidence interval [CI], 0.23–0.94; P for trend = 0.03), whereas no significant association was observed in women. When examining the association between serum 25(OH)D concentrations and components of sarcopenia, the third quartile was associated with lower odds of low muscle mass in men (OR, 0.39; 95% CI, 0.20–0.77) and low physical performance in women (OR, 0.32; 95% CI, 0.15–0.68), compared to the first quartile. Additionally, higher serum 25(OH)D concentrations were associated with more favorable annual changes in usual gait speed in men but not in women.</div></div><div><h3>Conclusion</h3><div>Low serum 25(OH)D concentrations are associated with a higher likelihood of incident sarcopenia and its components, particularly among men. Adequate 25(OH)D concentrations may help slow age-related decline in muscle mass and function, with potential sex differences.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100713"},"PeriodicalIF":4.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cMIND diet adherence and frailty among Chinese older adults: A 10-year longitudinal study","authors":"Lin Yang ,&nbsp;Mengying Li ,&nbsp;Jing Shu ,&nbsp;Lizheng Cao","doi":"10.1016/j.jnha.2025.100709","DOIUrl":"10.1016/j.jnha.2025.100709","url":null,"abstract":"<div><h3>Background</h3><div>Both cognitive impairment and diet are significant factors associated with frailty, however, the association between the Chinese Mediterranean-DASH Intervention for Neurodegenerative Delay (cMIND) diet and frailty remains unclear.</div></div><div><h3>Methods</h3><div>This longitudinal study analyzed data from 1,943 adults aged ≥65 in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) spanning 2008–2018. Adherence to the cMIND diet was assessed using a food frequency questionnaire, whereas frailty status was determined using the frailty index. The cMIND dietary scores were categorized into three groups based on tertiles: (T1:0−4; T2:4.5–5.5; T3:6–12). The association between cMIND adherence and frailty incidence was assessed using Cox proportional hazards models, while the dose-response relationship was examined with restricted cubic splines (with knots at the 5th, 35th, 65th, and 95th percentiles).</div></div><div><h3>Results</h3><div>The mean age was 74.9 ± 7.3 years; 50.5% were female. The restricted cubic spline model revealed a significant nonlinear association between baseline cMIND dietary scores and frailty risk (nonlinear <em>p</em> &lt; 0.05). Subsequently, the Cox proportional hazards model showed that, after adjusting for covariates, participants in the highest tertile of cMIND scores exhibited a 16% reduction in frailty risk compared to those in the lowest tertile (HR = 0.84, 95% CI: 0.72−0.97, <em>p</em> = 0.022). However, subgroup analyses revealed that the association varied according to baseline cognitive function. A significant inverse association was present in those with normal cognition (HR = 0.91, 95% CI: 0.86−0.96) but absent in those with cognitive impairment (HR = 1.01, 95% CI: 0.93–1.09; interaction <em>p</em> = 0.037).</div></div><div><h3>Conclusion</h3><div>Higher adherence to the cMIND diet is associated with a lower risk of frailty among older adults in China, specifically in those with normal cognitive function at baseline.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100709"},"PeriodicalIF":4.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building a roadmap to nutrition for Healthy Ageing: a brief report on the ILSI Europe Healthy Ageing Task Force","authors":"Leonie Lang ,&nbsp;Thomas Hunt ,&nbsp;David Vauzour ,&nbsp;Philipe de Souto Barreto ,&nbsp;Miguel Gueimonde ,&nbsp;Renger Witkamp ,&nbsp;Isabelle Guelinckx ,&nbsp;Bruno Pot ,&nbsp;Simon McArthur ,&nbsp;Louise Dye ,&nbsp;Lesley Hoyles ,&nbsp;Nils Billecke ,&nbsp;Andrea Bertocco ,&nbsp;Maria Camprubi Robles ,&nbsp;Caroline Perreau ,&nbsp;Gabriele Civiletto ,&nbsp;Maria Tonti","doi":"10.1016/j.jnha.2025.100683","DOIUrl":"10.1016/j.jnha.2025.100683","url":null,"abstract":"<div><div>At the end of October 2024, ILSI Europe brought together industry and academic experts from different fields to identify research gaps and challenges in nutritional interventions supporting healthy ageing. The objectives of the Healthy Ageing Working Group workshop were to address the urgent need to define ageing outcomes and associated biomarkers, determine the trajectory of functional ageing across the lifespan, and leverage technology to tailor nutritional and lifestyle interventions for healthy ageing. This brief report presents the key points highlighted during this workshop.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100683"},"PeriodicalIF":4.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why frailty must be central in anti-amyloid therapies for Alzheimer’s disease","authors":"Jorge G. Ruiz","doi":"10.1016/j.jnha.2025.100708","DOIUrl":"10.1016/j.jnha.2025.100708","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100708"},"PeriodicalIF":4.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lemon myrtle extract enhances muscle hypertrophy induced by low-load bodyweight resistance training in older adults: Findings from two independent randomized controlled trials","authors":"Shuji Sawada ,&nbsp;Azusa Nishino ,&nbsp;Shinichi Honda ,&nbsp;Yuji Tominaga ,&nbsp;Shiori Makio ,&nbsp;Hayao Ozaki ,&nbsp;Shuichi Machida","doi":"10.1016/j.jnha.2025.100706","DOIUrl":"10.1016/j.jnha.2025.100706","url":null,"abstract":"<div><h3>Objectives</h3><div>Previous literature has shown that combining lemon myrtle (LM) leaf extract with low-load resistance training may promote muscle hypertrophy. The current our studies aimed to verify the effects of LM intake combined with different training volumes on anterior thigh (AT) muscle thickness in older adults.</div></div><div><h3>Design</h3><div>Two independent randomized, double-blind, placebo-controlled trials.</div></div><div><h3>Setting</h3><div>Community-based training intervention program.</div></div><div><h3>Participants</h3><div>A total of 125 Japanese adults aged ≥65 years, with self-reported declines in muscle strength or walking ability. Study 1 (n = 47; LM group: n = 25, placebo group: n = 22) and Study 2 (n = 41; LM group: n = 22, placebo group: n = 19) were conducted independently, each with separate randomization into LM and placebo groups.</div></div><div><h3>Intervention</h3><div>Both studies involved low-load bodyweight resistance training twice weekly for 12 weeks. Study 1 compared LM + three sets of training with placebo + three sets; whereas Study 2 compared LM + one set with placebo + one set.</div></div><div><h3>Measurements</h3><div>AT muscle thickness (primary outcome) was assessed using B-mode ultrasound at baseline, 6, and 12 weeks. Secondary outcomes were normal walking speed (10-m walk test, m/s), maximum walking speed (10-m walk test, m/s), and 30-second chair stand (CS-30, repetitions).</div></div><div><h3>Results</h3><div>In Study 1, the LM + exercise group showed a greater increase in AT muscle thickness than the placebo + exercise group (12-week difference: 1.29 mm; 95% CI: −0.17 to 2.75 mm), although the difference was not statistically significant. In Study 2, the LM + exercise group showed a significant increase in AT muscle thickness compared with the placebo + exercise group (1.59 mm; 95% CI: 0.19–2.98 mm). No significant group-by-time interaction was found for secondary outcomes in either study.</div></div><div><h3>Conclusions</h3><div>LM intake may enhance muscle hypertrophy when combined with low-load resistance training in older adults with self-reported declines in muscle strength decline, particularly under low-volume training conditions. Further studies are needed to establish its clinical relevance.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100706"},"PeriodicalIF":4.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor regarding “Effects of nutritional education intervention on frailty status in lung cancer patients”","authors":"Parth Aphale ,&nbsp;Shashank Dokania ,&nbsp;Himanshu Shekhar","doi":"10.1016/j.jnha.2025.100707","DOIUrl":"10.1016/j.jnha.2025.100707","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100707"},"PeriodicalIF":4.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum leptin and accelerated biological aging in US adults: Findings from NHANES III","authors":"Kai Wei","doi":"10.1016/j.jnha.2025.100695","DOIUrl":"10.1016/j.jnha.2025.100695","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100695"},"PeriodicalIF":4.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain trajectories in relation to incident functional limitation among older adults: A prospective cohort study","authors":"Qiao Xiang ,&nbsp;Yuxiao Li ,&nbsp;Ziyi Zhong ,&nbsp;Wei Huang ,&nbsp;Jielei Chu ,&nbsp;Taiping Lin ,&nbsp;Birong Dong ,&nbsp;Jirong Yue ,&nbsp;Masoud Isanejad","doi":"10.1016/j.jnha.2025.100704","DOIUrl":"10.1016/j.jnha.2025.100704","url":null,"abstract":"<div><h3>Objectives</h3><div>We aimed to identify pain trajectories and examine their associations with incident functional limitation in older adults, including activities of daily living (ADL) and instrumental ADL (IADL).</div></div><div><h3>Design</h3><div>A prospective cohort study.</div></div><div><h3>Setting</h3><div>Community-based setting in western China.</div></div><div><h3>Participants</h3><div>We included participants with pain score information during 2018–2022, no prevalent functional limitation by 2022, and sufficient follow-up data for functional limitation assessment during 2023–2024.</div></div><div><h3>Measurements</h3><div>Group-based trajectory modeling was applied to identify pain trajectories based on the Numeric Rating Scale pain scores. Multivariate logistic regression models were used to assess the association between pain trajectories and incident ADL and IADL limitation. Sensitivity analyses were conducted using generalized estimating equations. Subgroup analyses were performed to assess potential interaction effects.</div></div><div><h3>Results</h3><div>A total of 887 older adults (all aged ≥60 years) were finally included in the analytic sample, of whom 139 (15.7%) and 198 (22.3%) individuals developed incident ADL and IADL limitation during the two-year follow-up, respectively. Four pain trajectories were identified: ‘<em>Persistently Pain-Free</em>’ (43.0%), ‘<em>Pain Remission</em>’ (16.7%), ‘<em>Developing Mild Pain</em>’ (21.9%), and ‘<em>Persistent Mild-to-Moderate Pain</em>’ (18.5%). Compared to the ‘<em>Persistently Pain-Free</em>’ group, only participants in the ‘<em>Persistent Mild-to-Moderate Pain</em>’ group had a significantly higher risk of developing ADL limitation (adjusted odds ratio = 2.19, 95% CI 1.32–3.63). No significant associations were found between any pain trajectory and the risk of incident IADL limitation. No significant interactions were observed in the subgroup analyses for either ADL or IADL (P for interaction &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Persistent pain, even at mild-to-moderate levels, independently predicts incident limitation in ADL rather than IADL in older adults, while achieving pain remission may help prevent functional decline in ADL. These findings underscore the importance of early identification and management of persistent pain to help maintain functional independence.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100704"},"PeriodicalIF":4.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of standard dietary inflammatory index with diabetic retinopathy in diabetes: A prospective cohort study","authors":"Zihan Xu ,&nbsp;Feipeng Jiang ,&nbsp;Yun Zhang ,&nbsp;Jier Ma ,&nbsp;Jianjun Ren ,&nbsp;Meixia Zhang","doi":"10.1016/j.jnha.2025.100694","DOIUrl":"10.1016/j.jnha.2025.100694","url":null,"abstract":"<div><h3>Background and aims</h3><div>Diabetic retinopathy (DR) is a major cause of vision impairment, and its development is linked to chronic inflammation. Investigating the role of dietary patterns, specifically the standard dietary inflammatory index (DII), may provide insights into modifiable risk factors for DR.</div></div><div><h3>Objective</h3><div>To quantify the impact of dietary inflammatory potential (assessed via the standard DII) on both risk of DR and structural alterations across individual retinal layers.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study using data from the UK Biobank. Cox proportional hazards models and restricted cubic splines were used to examine the correlation between the standard DII and DR in three adjusted models. Sensitivity analyses were performed to test the robustness of the outcomes. Linear regression models were employed to explore the associations between the standard DII and retinal structural parameters.</div></div><div><h3>Results</h3><div>Data from 16,224 participants with diabetes from the UK Biobank were analyzed, including 1,257 (7.75%) who developed DR during the follow-up period. Higher standard DII scores were associated with an increased risk of DR in all adjusted models [Model 3: HR = 1.51, 95% CI: (1.15, 1.99), p = 0.003]. A J-shaped association between standard DII scores and DR was observed, and the relationship was significant only when the standard DII score was greater than −2.5 [HR = 1.59, 95% CI: (1.44, 2.04), p = 0.002]. Subgroup analyses revealed consistent results across different stratified groups, indicating increased DR risk. Image analysis revealed that standard DII scores were associated with the thinning of the retinal pigment epithelium layer.</div></div><div><h3>Conclusions</h3><div>Our findings suggest a J-shaped association between standard DII score and DR risk in a multiracial sample from the UK Biobank. These findings indicate that an anti-inflammatory diet may be promising for mitigating the onset of DR.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100694"},"PeriodicalIF":4.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Egg intake and cognitive function in healthy adults: A systematic review of the literature","authors":"Nessmah Sultan ,&nbsp;Nicole J. Kellow ,&nbsp;Caroline J. Tuck ,&nbsp;Edellyne Cheng ,&nbsp;Clare MacMahon ,&nbsp;Jessica R. Biesiekierski","doi":"10.1016/j.jnha.2025.100696","DOIUrl":"10.1016/j.jnha.2025.100696","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive decline is a growing public health concern, particularly in aging populations. Eggs are a widely consumed, nutrient-dense food containing choline, phospholipids, tryptophan, and omega-3 fatty acids, which individually support cognitive processes such as memory, attention, and neurogenesis. While these individual nutrients have demonstrated benefits in supplementation studies, the cognitive effects of whole egg consumption are not well established. This systematic review aimed to evaluate the association between whole egg consumption and cognitive function in healthy adults.</div></div><div><h3>Methods</h3><div>A systematic search of five electronic databases (Medline, Embase, CINAHL Plus, SCOPUS, and PsychInfo) was conducted from database inception through February 2025. Studies were included if they investigated whole egg intake in relation to cognitive outcomes in healthy adults. Risk of bias was assessed using tools appropriate to study design. Due to heterogeneity in study methods, outcomes were synthesised narratively. Cognitive outcomes were categorised into domains including global cognitive function, memory, executive function, language, processing speed, and dementia risk.</div></div><div><h3>Results</h3><div>Eleven studies met the inclusion criteria: one pre-post intervention study, six prospective cohort studies, three cross-sectional studies, and one case-control study. Study populations were predominantly older adults and included &gt;38,000 participants. Two studies reported a reduced risk of dementia or cognitive impairment associated with moderate egg consumption (approximately 0.5–1 egg per day), while one study found increased risk at high intake levels (Over 1 egg per day). Several studies showed improvements in memory, verbal fluency, or processing speed with moderate—but not high—egg intake. The pre-post study reported improved reaction time following eight weeks of daily egg consumption (2 eggs per day). Heterogeneity in exposure measurement and cognitive testing methods limited direct comparisons across studies.</div></div><div><h3>Discussion</h3><div>Moderate whole egg consumption may be associated with improvements in cognitive outcomes in healthy adults, including reduced dementia risk and better memory performance. However, findings are inconsistent and limited by differences in study design, dietary assessment, and cognitive testing. Further well-controlled intervention studies are needed to determine optimal intake levels, explore mechanisms, and assess whether eggs can be integrated meaningfully into dietary strategies to support cognitive aging. (PROSPERO registration: 408532).</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100696"},"PeriodicalIF":4.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}