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Cost-effectiveness of protein-rich meals and snacks for increasing protein intake in older adults 增加老年人蛋白质摄入量的富含蛋白质的正餐和点心的成本效益
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-27 DOI: 10.1016/j.jnha.2024.100381
P. Rautakallio-Järvinen , S. Kunvik , M. Laaksonen , L. Fogelholm , I. Nykänen , U. Schwab

Objectives

To investigate the cost-effectiveness of protein-rich meals and snacks for increasing protein intake in home-dwelling older adults.

Design

Cost effectiveness analysis from a randomized controlled trial, the Power Meals study.

Setting

Participants were randomized into one of three groups for eight weeks: a protein-rich meal, snack and bread (Protein), a regular meal (Normal) and a control group without meal service (Control).

Participants

Home-dwelling home care clients, caregivers and care recipients aged ≥65 years (n = 65).

Measurements

Protein intake was assessed by a three-day food diary at the end of the study. Cost for the daily diet was estimated by using Finnish grocery store databases and the prices of the food service. The cost-effectiveness was assessed by an incremental cost-effectiveness ratio (ICER).

Results

Costs for the daily diet in the Protein (8.35 €/d) and the Normal (7.94 €/d) groups were significantly higher than in the control group (5.65 €/d) (p < 0.001). Incremental cost-effectiveness analysis showed that increasing protein intake was cost-effective in the Protein group as incremental cost-effectiveness ratio was 8.11 in the Protein, 8.72 in the Normal and 6.45 in the Control group.

Conclusions

Including protein rich meals and snacks in a diet increases protein intake in home-dwelling older adults cost-effectively.
目的研究富含蛋白质的正餐和点心在增加居家老年人蛋白质摄入量方面的成本效益。设置参与者被随机分为三组,每组八周:富含蛋白质的正餐、点心和面包组(蛋白质组)、普通正餐组(普通组)和不提供膳食服务的对照组(对照组)。日常饮食成本通过芬兰杂货店数据库和餐饮服务价格进行估算。结果蛋白质组(8.35 欧元/天)和正常组(7.94 欧元/天)的日常饮食成本明显高于对照组(5.65 欧元/天)(p < 0.001)。增量成本效益分析表明,蛋白质组增加蛋白质摄入量具有成本效益,因为蛋白质组的增量成本效益比为 8.11,正常组为 8.72,对照组为 6.45。
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引用次数: 0
Association of ultra-processed food intake with severe non-alcoholic fatty liver disease: a prospective study of 143073 UK Biobank participants 超加工食品摄入量与严重非酒精性脂肪肝的关系:对 143073 名英国生物数据库参与者的前瞻性研究
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-27 DOI: 10.1016/j.jnha.2024.100352
Yi-Feng Zhang , Wanning Qiao , Jinhong Zhuang , Hanxiao Feng , Zhilan Zhang , Yang Zhang

Background

Previous studies indicate a link between non-alcoholic fatty liver disease (NAFLD) and unhealthy dietary patterns or nutrient intake. However, it remains unclear whether ultra-processed foods (UPF) contribute to an increased risk of NAFLD. This study aimed to explore how ultra-processed food consumption correlates with severe NAFLD using the UK Biobank data.

Methods

This prospective cohort study included 143,073 participants from the UK Biobank. UPF consumption levels were determined using the NOVA classification and quantified from 24-h dietary recall data. The association between UPF consumption and severe NAFLD (hospitalization or death) was initially examined using Cox proportional hazards models with intake quartiles. Nonlinear associations were investigated using penalized cubic splines fitted in the Cox proportional hazards models. Adjustments were made for general characteristics, sociodemographic factors, body mass index (BMI), and lifestyle.

Results

Throughout the median follow-up period of 10.5 years, 1,445 participants developed severe NAFLD. The adjusted models indicated a significant increase in severe NAFLD risk in higher UPF intake groups compared to the lowest quartile (HR: 1.26 [95% CI: 1.11–1.43]). Subgroup analysis revealed that individuals with a BMI of 25 or higher were at greater risk in the highest quartile of UPF consumption. Sensitivity analyses yielded results consistent with these findings.

Conclusion

Higher consumption of UPF is associated with an increased risk of severe NAFLD. Reducing the intake of UPF can be a potential approach to lower the risk of NAFLD.
背景以往的研究表明,非酒精性脂肪肝(NAFLD)与不健康的饮食模式或营养摄入之间存在联系。然而,超加工食品(UPF)是否会导致非酒精性脂肪肝风险增加,目前仍不清楚。这项研究旨在利用英国生物库的数据,探讨超加工食品的摄入量与严重非酒精性脂肪肝的相关性。这项前瞻性队列研究纳入了英国生物库中的143,073名参与者,采用NOVA分类法确定UPF消费水平,并根据24小时饮食回忆数据进行量化。采用摄入量四分位数的考克斯比例危险模型初步检验了UPF摄入量与严重非酒精性脂肪肝(住院或死亡)之间的关系。在Cox比例危险模型中使用惩罚性立方样条来研究非线性关联。结果在中位 10.5 年的随访期间,有 1,445 名参与者患上了严重的非酒精性脂肪肝。调整后的模型显示,与最低四分位数相比,UPF摄入量较高的人群患严重非酒精性脂肪肝的风险明显增加(HR:1.26 [95% CI:1.11-1.43])。亚组分析显示,体重指数为25或更高的人在UPF摄入量最高的四分位组中风险更大。结论较高的 UPF 摄入量与严重非酒精性脂肪肝的风险增加有关。减少UPF的摄入量是降低非酒精性脂肪肝风险的一种潜在方法。
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引用次数: 0
Association of allostatic load with functional disability in the China Health and Retirement Longitudinal Study 中国健康与退休纵向研究中异位负荷与功能障碍的关系
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-27 DOI: 10.1016/j.jnha.2024.100367
Wanyu Zhao , Yanjun Si , Xueqin Li , Yunli Zhao , Shuli Jia , Birong Dong

Objectives

Allostatic load (AL) is an index that manifests as cumulative wear and tear on multiple physiological systems resulting from repeated adaptation to stressors throughout the life course. Higher AL was found to be associated with increased risk of adverse health outcomes, but studies on functional disability among large Chinese older population were limited. We aimed to investigate the associations of AL with functional disability among Chinese older adults.

Research design and methods

This prospective cohort study included 5880 older adults who were at least 50 years old and participated in the CHARLS at baseline (2011 wave), with 3 follow-ups (2013, 2015 and 2018 waves). We selected 11 biomarkers from 4 physiological systems to construct AL. AL score was classified into three categories based on tertiles: 0–1 (low burden), 2–3 (medium burden) and 4–11 (high burden). Functional disability was assessed by activities of daily living (ADL) and instrumental activities of daily living (IADL). Multivariable logistic regression models examined the association between baseline AL, transitions of AL burden and incidence of functional disability.

Results

In cross-sectional analyses, medium and high AL burden were associated with an increased prevalence of ADL disability, while association was only significant between high AL burden and IADL disability. During the 7-year follow-up, 1102 and 1777 participants incident ADL disability and IADL disability, respectively. Those with medium and high AL burden had an increased risk of new-onset ADL disability than those with low AL burden (“medium”: OR = 1.25, 95%CI = 1.01, 1.55; “high”: OR = 1.69, 95%CI = 1.32, 2.18). As for IADL disability, association was only significant in “high” group (OR = 1.50, 95% CI = 1.24, 1.83). We also found keep medium/high AL burden in 2011 and 2015 was associated with new-onset ADL (OR = 2.27, 95%CI = 1.50, 3.44) and IADL disability (OR = 1.51, 95%CI = 1.11, 2.05) in 2018.

Conclusion

These results show that higher AL predicts functional disability among Chinese older adults. Monitoring AL and paying close attention to those with medium/high AL burden may aid prevention of adverse health outcomes, thus giving a healthier ageing experience to a large proportion of the population.
目的 静力负荷(Allostatic load,AL)是一个指数,表现为在整个生命过程中因反复适应压力因素而对多个生理系统造成的累积磨损。研究发现,较高的静力负荷与不良健康后果风险的增加有关,但有关中国老年人群功能障碍的研究却很有限。研究设计和方法这项前瞻性队列研究纳入了5880名年龄至少50岁、基线(2011年波)时参加了CHARLS的老年人,并进行了3次随访(2013年、2015年和2018年波)。我们从 4 个生理系统中选取了 11 个生物标志物来构建 AL。AL得分根据梯度分为三类:0-1(低负担)、2-3(中等负担)和 4-11(高负担)。功能障碍通过日常生活活动(ADL)和工具性日常生活活动(IADL)进行评估。多变量逻辑回归模型检验了基线AL、AL负担的转变与功能性残疾发生率之间的关联。结果在横断面分析中,中度和高度AL负担与ADL残疾发生率的增加有关,而高度AL负担与IADL残疾之间的关联仅有显著性。在7年的随访中,分别有1102名和1777名参与者出现了ADL残疾和IADL残疾。与低AL负担者相比,中度和高度AL负担者新发ADL残疾的风险更高("中度":OR=1.25,95%IR=1.25,95%IR=1.25):OR=1.25,95%CI=1.01,1.55;"高":OR=1.69,95%CI=1.32,2.18)。至于 IADL 残疾,只有 "高 "组的相关性显著(OR = 1.50,95% CI = 1.24,1.83)。我们还发现,2011 年和 2015 年的中/高 AL 负担与 2018 年新发的 ADL(OR = 2.27,95%CI = 1.50,3.44)和 IADL 残疾(OR = 1.51,95%CI = 1.11,2.05)相关。监测AL并密切关注中/高AL负担人群可能有助于预防不良健康后果,从而为大部分人群带来更健康的老年生活。
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引用次数: 0
Biological sex as a tailoring variable for exercise prescription in hospitalized older adults 将生理性别作为住院老年人运动处方的定制变量
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-27 DOI: 10.1016/j.jnha.2024.100377
Mikel L. Sáez de Asteasu , Nicolás Martínez-Velilla , Robinson Ramírez-Vélez , Fabricio Zambom-Ferraresi , Arkaitz Galbete , Eduardo L. Cadore , Mikel Izquierdo

Background

Sex-based differences in the clinical presentation and outcomes are well-established in patients hospitalized for geriatric syndromes. We aimed to investigate sex differences in response to in-hospital exercise on function, strength, cognition, and quality of life in acute care admissions.

Methods

570 patients (mean age 87 years, 298 females [52.3%]) admitted to acute care for elderly units were randomized to multicomponent exercise emphasizing progressive resistance training or usual care. Functional assessments included Short Physical Performance Battery (SPPB), grip strength, Mini-Mental State Examination (MMSE), and health-related quality of life (EQ-VAS).

Results

Exercising females showed more significant SPPB improvements than males (between-group difference 1.48 points, p = 0.027), exceeding the minimal clinically significant difference. While female participants significantly increased handgrip strength and male patients improved cognition after in-hospital exercise compared to the control group (all p < 0.001), no sex differences occurred.

Conclusions

Females demonstrate more excellent physical function improvements compared to male older patients. Findings highlight the importance of tailored exercise incorporating patient factors like biological sex in geriatric medicine.

Trial registration

NCT04600453.
背景因老年综合症住院的患者在临床表现和预后方面的性别差异已得到证实。我们的目的是研究急诊入院患者对院内运动在功能、力量、认知和生活质量方面的反应的性别差异。方法:570 名老年急诊入院患者(平均年龄 87 岁,298 名女性 [52.3%])被随机分配到强调渐进阻力训练的多组分运动或常规护理中。功能评估包括短期体能测试(SPPB)、握力、迷你精神状态检查(MMSE)和与健康相关的生活质量(EQ-VAS)。结果与男性相比,锻炼女性的SPPB改善更为显著(组间差异为1.48分,P = 0.027),超过了最小临床显著性差异。与对照组相比,女性参与者的手握力明显增强,男性患者在院内锻炼后认知能力有所提高(均为 p <0.001),但无性别差异。结论与男性老年患者相比,女性患者的身体功能改善更为显著。研究结果凸显了在老年医学中结合患者生理性别等因素进行量身定制运动的重要性。
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引用次数: 0
Development of an older adult Nutrition Equity Index (NEI) and association with the Healthy Eating Index (HEI) in older Black and White U.S. adults 美国黑人和白人老年人营养公平指数(NEI)的制定及其与健康饮食指数(HEI)的联系
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-25 DOI: 10.1016/j.jnha.2024.100343
Aarohee P. Fulay , Samaneh Farsijani , Kerri Freeland , Jimmie Roberts , Andrea L. Rosso , Denise K. Houston , Elsa S. Strotmeyer

Objectives

We developed a novel measure for older U.S. adults called the Nutrition Equity Index (NEI), which includes functional ability. We compared both the NEI and food insufficiency with Healthy Eating Index (HEI) scores.

Design

The Health, Aging, and Body Composition Study is a prospective, longitudinal cohort of Medicare-eligible, community-dwelling Black and White men and women.

Setting

Pittsburgh, PA and Memphis, TN.

Participants

Participants (N = 2468, aged 74.7 ± 2.9 years) had baseline (1997−98) and 1-year follow-up NEI data; and 1 year follow-up for food insufficiency, key covariates, and the HEI (diet quality measure) from a 108-item interviewer-administered food frequency questionnaire.

Measurements

Food insufficiency was defined from a modified validated question on ample food amount/variety from the U.S. Department of Agriculture. NEI was constructed from 8 questions in three subdomains: food insecurity (food insufficiency, hunger, anxiety about limited food, limited money for food), food access (groceries), and food acquisition (difficulty shopping, preparing meals, carrying groceries). Final NEI categories were low nutrition equity (0), moderate nutrition equity (1), and high nutrition equity (2). Multivariable linear regression compared both NEI and food insufficiency with HEI, adjusted for sociodemographic, lifestyle and comorbidity factors.

Results

Of participants, 13.5% had food insufficiency, 12.1% had low NEI, and 32.5% had moderate NEI. Participants with food insufficiency (vs. food sufficiency) or low NEI (vs. high NEI) were more likely to be Black and have < high school education (both p < 0.0001). In minimally adjusted models, food insufficiency was associated with 2.2 point lower HEI score (p = 0.001), low NEI with 2.6 point lower HEI score (p = 0.001), and moderate NEI with 1.0 point lower HEI score (p < 0.05). Adjusting for race attenuated NEI associations with HEI to non-significance. After multivariable adjustment, food insufficiency was associated with 1.5 point lower HEI score (p = 0.03).

Conclusion

Food insufficiency was associated with lower dietary quality in this sample of older Black and White U.S. adults. NEI performed similarly to food insufficiency for HEI associations prior to multivariable adjustment and identified more older adults with nutrition inequity, who may be at risk for poor health outcomes.
目标我们为美国老年人开发了一种名为营养公平指数(NEI)的新测量方法,其中包括功能能力。我们将营养公平指数和食物不足指数与健康饮食指数 (HEI) 的得分进行了比较。参与者(N = 2468,年龄为 74.7 ± 2.9 岁)拥有基线(1997-1998 年)和 1 年随访的 NEI 数据;以及 1 年随访的食物不足、主要协变量和 HEI(饮食质量测量)数据,这些数据来自由访问者管理的 108 项食物频率问卷。NEI由三个子域中的8个问题构成:食物不安全(食物不足、饥饿、对食物有限的焦虑、购买食物的钱有限)、食物获取(杂货)和食物获取(购物、准备膳食、携带杂货的困难)。最终的营养公平指数类别为低营养公平指数(0)、中营养公平指数(1)和高营养公平指数(2)。多变量线性回归比较了NEI和食物不足与HEI,并对社会人口学、生活方式和合并症等因素进行了调整。结果 在参与者中,13.5%的人存在食物不足,12.1%的人存在低NEI,32.5%的人存在中度NEI。食物不足(vs.食物充足)或低NEI(vs.高NEI)的参与者更有可能是黑人且具有<高中学历(均为p<0.0001)。在最小调整模型中,食物不足与 HEI 分数降低 2.2 分相关(p = 0.001),低 NEI 与 HEI 分数降低 2.6 分相关(p = 0.001),中度 NEI 与 HEI 分数降低 1.0 分相关(p <0.05)。调整种族因素后,NEI 与 HEI 的相关性减弱至不显著。结论在美国老年黑人和白人样本中,食物不足与较低的膳食质量有关。在进行多变量调整之前,NEI 与食物不足在 HEI 关联性方面的表现类似,并且发现了更多存在营养不均的老年人,他们可能面临不良健康后果的风险。
{"title":"Development of an older adult Nutrition Equity Index (NEI) and association with the Healthy Eating Index (HEI) in older Black and White U.S. adults","authors":"Aarohee P. Fulay ,&nbsp;Samaneh Farsijani ,&nbsp;Kerri Freeland ,&nbsp;Jimmie Roberts ,&nbsp;Andrea L. Rosso ,&nbsp;Denise K. Houston ,&nbsp;Elsa S. Strotmeyer","doi":"10.1016/j.jnha.2024.100343","DOIUrl":"10.1016/j.jnha.2024.100343","url":null,"abstract":"<div><h3>Objectives</h3><div>We developed a novel measure for older U.S. adults called the Nutrition Equity Index (NEI), which includes functional ability. We compared both the NEI and food insufficiency with Healthy Eating Index (HEI) scores.</div></div><div><h3>Design</h3><div>The Health, Aging, and Body Composition Study is a prospective, longitudinal cohort of Medicare-eligible, community-dwelling Black and White men and women.</div></div><div><h3>Setting</h3><div>Pittsburgh, PA and Memphis, TN.</div></div><div><h3>Participants</h3><div>Participants (N = 2468, aged 74.7 ± 2.9 years) had baseline (1997−98) and 1-year follow-up NEI data; and 1 year follow-up for food insufficiency, key covariates, and the HEI (diet quality measure) from a 108-item interviewer-administered food frequency questionnaire.</div></div><div><h3>Measurements</h3><div>Food insufficiency was defined from a modified validated question on ample food amount/variety from the U.S. Department of Agriculture. NEI was constructed from 8 questions in three subdomains: food insecurity (food insufficiency, hunger, anxiety about limited food, limited money for food), food access (groceries), and food acquisition (difficulty shopping, preparing meals, carrying groceries). Final NEI categories were low nutrition equity (0), moderate nutrition equity (1), and high nutrition equity (2). Multivariable linear regression compared both NEI and food insufficiency with HEI, adjusted for sociodemographic, lifestyle and comorbidity factors.</div></div><div><h3>Results</h3><div>Of participants, 13.5% had food insufficiency, 12.1% had low NEI, and 32.5% had moderate NEI. Participants with food insufficiency (vs. food sufficiency) or low NEI (vs. high NEI) were more likely to be Black and have &lt; high school education (both p &lt; 0.0001). In minimally adjusted models, food insufficiency was associated with 2.2 point lower HEI score (p = 0.001), low NEI with 2.6 point lower HEI score (p = 0.001), and moderate NEI with 1.0 point lower HEI score (p &lt; 0.05). Adjusting for race attenuated NEI associations with HEI to non-significance. After multivariable adjustment, food insufficiency was associated with 1.5 point lower HEI score (p = 0.03).</div></div><div><h3>Conclusion</h3><div>Food insufficiency was associated with lower dietary quality in this sample of older Black and White U.S. adults. NEI performed similarly to food insufficiency for HEI associations prior to multivariable adjustment and identified more older adults with nutrition inequity, who may be at risk for poor health outcomes.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 11","pages":"Article 100343"},"PeriodicalIF":4.3,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intake of vegetables and fruits at midlife and the risk of physical frailty in later life 中年时蔬菜和水果的摄入量与晚年身体虚弱的风险
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-23 DOI: 10.1016/j.jnha.2024.100374
Kevin Yiqiang Chua , Huiqi Li , Li-Ting Sheng , Wee-Shiong Lim , Woon-Puay Koh

Objectives

Our study evaluated the independent and overall associations of vegetable and fruit consumption at midlife with the likelihood of physical frailty in later life. We also investigated whether specific nutrients in these foods could have accounted for these associations, if present.

Design

Prospective cohort study.

Setting

A population-based cohort of Chinese adults followed over a period of 20 years in Singapore.

Participants

We used data from 11,959 subjects who participated in the baseline (1993–1998) and follow-up 3 (2014–2017) interviews of the Singapore Chinese Health Study.

Measurements

At baseline, dietary intake was evaluated using a validated food frequency questionnaire. During the follow-up 3 visits, physical frailty was assessed using a modified Cardiovascular Health Study phenotype that included weakness, slowness, exhaustion and weight loss. Multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the associations with physical frailty.

Results

Participants had mean ages of 52 years at baseline, and 72 years at follow-up 3. Baseline intake of vegetables, but not of fruits, showed a dose-dependent inverse relationship with physical frailty at follow-up 3 (Ptrend = 0.001). Compared to participants in the lowest quintile of vegetable intake, those in the highest quintile had reduced odds of frailty [OR (95% CI): 0.73 (0.60−0.89)]. Among the components of physical frailty, vegetable intake had the strongest inverse association with weakness defined by handgrip strength [OR (95% CI) between extreme quintiles: 0.62 (0.52−0.73); Ptrend < 0.001]. In models that were individually adjusted for nutrients, the vegetable-frailty association was attenuated and no longer statistically significant after adjusting for the intake of β-carotene, lutein, folate, α-carotene, and isothiocyanates.

Conclusion

: Increased midlife intake of vegetables was associated with reduced odds of physical frailty in later life, and the intake of β-carotene, lutein, folate, α-carotene, and isothiocyanates could have accounted for this association.
我们的研究评估了中年时蔬菜和水果消费量与晚年身体虚弱可能性之间的独立和整体关联。我们使用了 11959 名受试者的数据,这些受试者参加了新加坡华人健康研究的基线(1993-1998 年)和后续 3 次(2014-2017 年)访谈。测量基线时,我们使用经过验证的食物频率问卷评估了饮食摄入量。在后续 3 次访谈中,使用修改后的心血管健康研究表型评估身体虚弱情况,包括虚弱、迟钝、疲惫和体重减轻。采用多变量逻辑回归模型估算了与身体虚弱相关的几率比(OR)和 95% 的置信区间(CI)。与蔬菜摄入量最低五分位数的参与者相比,蔬菜摄入量最高五分位数的参与者身体虚弱的几率较低[OR (95% CI):0.73 (0.60-0.89)]。在体质虚弱的各组成部分中,蔬菜摄入量与以手握强度定义的体质虚弱的反向关系最为密切[极端五分位数之间的OR(95% CI):0.62(0.52-0.73);Ptrend < 0.001]。在对营养素进行单独调整的模型中,在调整了β-胡萝卜素、叶黄素、叶酸、α-胡萝卜素和异硫氰酸盐的摄入量后,蔬菜与肥胖的关系有所减弱,不再具有显著的统计学意义:结论:中年时期蔬菜摄入量的增加与晚年身体虚弱几率的降低有关,β-胡萝卜素、叶黄素、叶酸、α-胡萝卜素和异硫氰酸盐的摄入量可能是造成这种关联的原因。
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引用次数: 0
Gender-specific capacity of insulin resistance proxies to predict functional decline in older adults 胰岛素抵抗代用指标预测老年人功能衰退的能力因性别而异
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-23 DOI: 10.1016/j.jnha.2024.100376
Mariam El Assar , Javier Angulo , José Antonio Carnicero , Begoña Molina-Baena , Francisco José García-García , Patricia Sosa , Leocadio Rodríguez-Mañas

Objectives

Insulin resistance determined by Homeostasis Model of Insulin Resistance (HOMA-IR) has been associated with functional decline in non-diabetic older subjects. However, insulin is not routinely assessed. The study evaluated the predictive value of non-insulin-dependent IR surrogates on functional decline in non-diabetic older men and women.

Design and participants

Prospective cohort study over 5 years. The study included 615 older participants from the Toledo Study of Healthy Aging.

Methods

Frailty was assessed by the Frailty Trait Scale-5 (FTS-5) at baseline and after 5 years follow-up. 193 subjects experienced functional decline (2.5-point reduction in the FTS-5 score). Multivariate regression models analysed the effect of five described IR surrogates on functional decline considering potential confounders.

Results

Among evaluated IR proxies, triglyceride glucose-body mass index (TyG-BMI) and HOMA-IR were significantly associated with an increased risk of functional decline (odd ratio (95% confidence interval) TyG-BMI: 1.16 (1.05, 1.28), p = 0.0035 and HOMA-IR: 1.59 (1.15, 2.21), p = 0.0056) among all participants. When stratified by gender, HOMA-IR was related to functional decline in men [2.02 (1.13, 3.59), p = 0.0173] and TyG-BMI in women [1.19 (1.05, 1.35), p = 0.0057].

Conclusions

Only TyG-BMI index mimics the predictive capacity of insulin-based IR marker. The predictive ability of IR indexes is gender-specific, being TyG-BMI the only index able to predict functional decline in women and HOMA-IR in men.
目的通过胰岛素抵抗稳态模型(HOMA-IR)确定的胰岛素抵抗与非糖尿病老年人的功能衰退有关。然而,胰岛素并不是常规评估指标。该研究评估了非胰岛素依赖型红外替代物对非糖尿病老年男性和女性功能衰退的预测价值。研究对象包括托莱多健康老龄化研究(Toledo Study of Healthy Aging)中的 615 名老年参与者。方法在基线和随访 5 年后,用虚弱特质量表-5(FTS-5)评估虚弱程度。193名受试者出现功能衰退(FTS-5得分下降2.5分)。考虑到潜在的混杂因素,多变量回归模型分析了五种已描述的 IR 代用指标对功能衰退的影响。结果在所有参与者中,甘油三酯血糖-体重指数(TyG-BMI)和 HOMA-IR 与功能衰退风险增加显著相关(奇异比(95% 置信区间)TyG-BMI:1.16 (1.05, 1.28),p = 0.0035;HOMA-IR:1.59 (1.15, 2.21),p = 0.0056)。结论只有 TyG-BMI 指数模拟了基于胰岛素的 IR 指标的预测能力。IR指标的预测能力具有性别特异性,TyG-BMI是唯一能够预测女性功能衰退的指标,而HOMA-IR则是唯一能够预测男性功能衰退的指标。
{"title":"Gender-specific capacity of insulin resistance proxies to predict functional decline in older adults","authors":"Mariam El Assar ,&nbsp;Javier Angulo ,&nbsp;José Antonio Carnicero ,&nbsp;Begoña Molina-Baena ,&nbsp;Francisco José García-García ,&nbsp;Patricia Sosa ,&nbsp;Leocadio Rodríguez-Mañas","doi":"10.1016/j.jnha.2024.100376","DOIUrl":"10.1016/j.jnha.2024.100376","url":null,"abstract":"<div><h3>Objectives</h3><div>Insulin resistance determined by Homeostasis Model of Insulin Resistance (HOMA-IR) has been associated with functional decline in non-diabetic older subjects. However, insulin is not routinely assessed. The study evaluated the predictive value of non-insulin-dependent IR surrogates on functional decline in non-diabetic older men and women.</div></div><div><h3>Design and participants</h3><div>Prospective cohort study over 5 years. The study included 615 older participants from the Toledo Study of Healthy Aging.</div></div><div><h3>Methods</h3><div>Frailty was assessed by the Frailty Trait Scale-5 (FTS-5) at baseline and after 5 years follow-up. 193 subjects experienced functional decline (2.5-point reduction in the FTS-5 score). Multivariate regression models analysed the effect of five described IR surrogates on functional decline considering potential confounders.</div></div><div><h3>Results</h3><div>Among evaluated IR proxies, triglyceride glucose-body mass index (TyG-BMI) and HOMA-IR were significantly associated with an increased risk of functional decline (odd ratio (95% confidence interval) TyG-BMI: 1.16 (1.05, 1.28), p = 0.0035 and HOMA-IR: 1.59 (1.15, 2.21), p = 0.0056) among all participants. When stratified by gender, HOMA-IR was related to functional decline in men [2.02 (1.13, 3.59), p = 0.0173] and TyG-BMI in women [1.19 (1.05, 1.35), p = 0.0057].</div></div><div><h3>Conclusions</h3><div>Only TyG-BMI index mimics the predictive capacity of insulin-based IR marker. The predictive ability of IR indexes is gender-specific, being TyG-BMI the only index able to predict functional decline in women and HOMA-IR in men.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 11","pages":"Article 100376"},"PeriodicalIF":4.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004639/pdfft?md5=c552ecedf2a0505333cd34e206c0cdd5&pid=1-s2.0-S1279770724004639-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteosarcopenia predicts greater risk of functional disability than sarcopenia: a longitudinal analysis of FraDySMex cohort study 骨肉疏松症比肌肉疏松症更容易导致功能性残疾:FraDySMex 队列研究的纵向分析。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-21 DOI: 10.1016/j.jnha.2024.100368
Oscar Rosas-Carrasco , Betty Manrique-Espinoza , Juan Carlos López-Alvarenga , Beatriz Mena-Montes , Isabel Omaña-Guzmán

Objectives

Aging involves significant changes in body composition, marked by declines in muscle mass and bone mineral density alongside an increase in fat mass. Sarcopenia is characterized by low strength and muscle mass, and osteosarcopenia is the coexistence of sarcopenia and osteopenia/osteoporosis. Physiologically, there is a crosstalk between muscle and bone tissues mediated by several pathways. Both, sarcopenia and osteosarcopenia, have been related with adverse outcomes such as functional disability. However, there is a lack of longitudinal studies. Therefore, this study aimed to assess whether sarcopenia and osteosarcopenia phenotypes increased the risk of functional disability in a longitudinal cohort of community-dwelling adults.

Design

This study constitutes a secondary longitudinal analysis of data derived from the prospective cohort FraDySMex (Frailty, Dynapenia, and Sarcopenia in Mexican adults).

Setting and participants

FraDySMex is conducted in community-dwelling adults aged 50 years or older living in Mexico City. Data from 2014 to 2015 was considered as baseline evaluation, and the 2019 wave was the follow-up evaluation. Individuals with complete baseline and follow-up evaluations were included in the analysis.

Measurements

Sarcopenia diagnosis adhered to the FNIH criteria, while osteopenia/osteoporosis classification followed WHO guidelines. Osteosarcopenia was defined as the concurrent presence of sarcopenia and osteopenia/osteoporosis. Functional disability was identified by the Lawton Instrumental Activities of Daily Living (IADL) Scale. Adjusted mixed-effects logistic regression models were estimated to evaluate the effect of body composition phenotype on the risk of functional disability.

Results

The final sample included 320 adults with complete longitudinal data. The majority of were women (83.4%) and had 7–12 years of education (48.4%). At the baseline evaluation, 50.9% aged 50–70. The osteosarcopenia phenotype was associated with a higher risk of functional disability (OR: 2.17, p = 0.042) compared with the no osteopenia/sarcopenia group. Conversely, sarcopenia (OR: 1.50, p = 0.448) and osteopenia/osteoporosis (OR: 1.50, p = 0.185) phenotypes were not associated with functional disability.

Conclusions

Our study underscores that osteosarcopenia significantly increased the risk of functional disability, particularly in terms of Instrumental Activities of Daily Living (IADL). These results emphasize the importance of screening for sarcopenia, osteopenia/osteoporosis, and osteosarcopenia across various clinical settings. Early detection and intervention hold promise for averting functional disability and mitigating associated adverse outcomes in adults.
目的:衰老会导致身体成分发生重大变化,表现为肌肉质量和骨矿物质密度下降,同时脂肪量增加。肌肉疏松症的特点是力量和肌肉质量下降,而骨质疏松症则是肌肉疏松症和骨质疏松/骨质疏松症的并存。从生理学角度看,肌肉和骨骼组织之间存在着由多种途径介导的相互影响。肌肉疏松症和骨质疏松症都与功能性残疾等不良后果有关。然而,目前还缺乏纵向研究。因此,本研究旨在评估肌肉疏松症和骨质疏松症表型是否会增加社区成人纵向队列中功能性残疾的风险:本研究是对前瞻性队列 FraDySMex(墨西哥成年人虚弱、动力性和肌少症)数据的二次纵向分析:FraDySMex的研究对象是居住在墨西哥城的50岁或以上的社区成年人。2014年至2015年的数据被视为基线评估,2019年的数据为后续评估。具有完整基线和随访评估的个体均纳入分析:肌少症的诊断遵循 FNIH 标准,而骨质疏松症/骨质疏松症的分类遵循世界卫生组织指南。骨质疏松症是指同时存在肌肉疏松症和骨质疏松/骨质疏松症。功能性残疾通过劳顿日常生活活动量表(IADL)来确定。我们估算了调整后的混合效应逻辑回归模型,以评估身体成分表型对功能性残疾风险的影响:最终样本包括 320 名具有完整纵向数据的成年人。其中大部分为女性(83.4%),受教育年限为 7-12 年(48.4%)。在基线评估中,50.9%的人年龄在 50-70 岁之间。与无骨质疏松症/肌肉疏松症组相比,骨质疏松症表型与较高的功能性残疾风险相关(OR:2.17,p = 0.042)。相反,肌肉疏松症(OR:1.50,p = 0.448)和骨质疏松症/骨质疏松症(OR:1.50,p = 0.185)表型与功能性残疾无关:我们的研究强调,骨肉疏松症会显著增加功能性残疾的风险,尤其是在日常生活工具性活动(IADL)方面。这些结果强调了在各种临床环境中筛查肌肉疏松症、骨质疏松症/骨质疏松症和骨肉疏松症的重要性。早期检测和干预有望避免成人功能性残疾并减轻相关不良后果。
{"title":"Osteosarcopenia predicts greater risk of functional disability than sarcopenia: a longitudinal analysis of FraDySMex cohort study","authors":"Oscar Rosas-Carrasco ,&nbsp;Betty Manrique-Espinoza ,&nbsp;Juan Carlos López-Alvarenga ,&nbsp;Beatriz Mena-Montes ,&nbsp;Isabel Omaña-Guzmán","doi":"10.1016/j.jnha.2024.100368","DOIUrl":"10.1016/j.jnha.2024.100368","url":null,"abstract":"<div><h3>Objectives</h3><div>Aging involves significant changes in body composition, marked by declines in muscle mass and bone mineral density alongside an increase in fat mass. Sarcopenia is characterized by low strength and muscle mass, and osteosarcopenia is the coexistence of sarcopenia and osteopenia/osteoporosis. Physiologically, there is a crosstalk between muscle and bone tissues mediated by several pathways. Both, sarcopenia and osteosarcopenia, have been related with adverse outcomes such as functional disability. However, there is a lack of longitudinal studies. Therefore, this study aimed to assess whether sarcopenia and osteosarcopenia phenotypes increased the risk of functional disability in a longitudinal cohort of community-dwelling adults.</div></div><div><h3>Design</h3><div>This study constitutes a secondary longitudinal analysis of data derived from the prospective cohort FraDySMex (Frailty, Dynapenia, and Sarcopenia in Mexican adults).</div></div><div><h3>Setting and participants</h3><div>FraDySMex is conducted in community-dwelling adults aged 50 years or older living in Mexico City. Data from 2014 to 2015 was considered as baseline evaluation, and the 2019 wave was the follow-up evaluation. Individuals with complete baseline and follow-up evaluations were included in the analysis.</div></div><div><h3>Measurements</h3><div>Sarcopenia diagnosis adhered to the FNIH criteria, while osteopenia/osteoporosis classification followed WHO guidelines. Osteosarcopenia was defined as the concurrent presence of sarcopenia and osteopenia/osteoporosis. Functional disability was identified by the Lawton Instrumental Activities of Daily Living (IADL) Scale. Adjusted mixed-effects logistic regression models were estimated to evaluate the effect of body composition phenotype on the risk of functional disability.</div></div><div><h3>Results</h3><div>The final sample included 320 adults with complete longitudinal data. The majority of were women (83.4%) and had 7–12 years of education (48.4%). At the baseline evaluation, 50.9% aged 50–70. The osteosarcopenia phenotype was associated with a higher risk of functional disability (OR: 2.17, p = 0.042) compared with the no osteopenia/sarcopenia group. Conversely, sarcopenia (OR: 1.50, p = 0.448) and osteopenia/osteoporosis (OR: 1.50, p = 0.185) phenotypes were not associated with functional disability.</div></div><div><h3>Conclusions</h3><div>Our study underscores that osteosarcopenia significantly increased the risk of functional disability, particularly in terms of Instrumental Activities of Daily Living (IADL). These results emphasize the importance of screening for sarcopenia, osteopenia/osteoporosis, and osteosarcopenia across various clinical settings. Early detection and intervention hold promise for averting functional disability and mitigating associated adverse outcomes in adults.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 11","pages":"Article 100368"},"PeriodicalIF":4.3,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S127977072400455X/pdfft?md5=886f20e9acb2a732ef2178384db5d845&pid=1-s2.0-S127977072400455X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing the role of social work in addressing social frailty and diet quality among older adults 加强社会工作在解决老年人社会脆弱性和饮食质量方面的作用。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-21 DOI: 10.1016/j.jnha.2024.100375
Qiong Yi , Guang Yao Wang , Zong Xiang Yue
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引用次数: 0
Validation of intrinsic capacity and healthy sleep pattern in middle-aged and older adults: a longitudinal Chinese study assessing healthy ageing 验证中老年人的内在能力和健康睡眠模式:一项评估健康老龄化的中国纵向研究。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-21 DOI: 10.1016/j.jnha.2024.100365
Xing-Ling Chen , Jin Li , Shu-Ning Sun , Xiao-Jiao Zhang , Jia-Hui Chen , Ling-Jun Wang , Zhong-Qi Yang , Shi-Hao Ni , Lu Lu

Objectives

Intrinsic capacity (IC), a multidimensional construct encompassing mental and physical capacities, has been established in the aging framework by the World Health Organization. However, the detailed relationship between IC and Chinese sleep patterns (nighttime sleep and post-lunch naps) remains inadequately elucidated.

Methods

Participants in this study were individuals aged ≥45 years residing in China, included in the China Health and Retirement Longitudinal Study (CHARLS). We analyzed 4 years of CHARLS data from the first wave (May 2011–March 2012) to the second wave (July 2015–January 2016). Data from these waves were utilized for longitudinal analysis. Self-reported data included nighttime sleep and nap duration, along with other baseline characteristics. The IC evaluation involved physical examinations and blood tests. Initially, linear regression was used to assess the relationship between total sleep duration, nighttime sleep duration, nap duration, and IC change between the two waves that were determined by marginal effects (ME) and their corresponding 95% confidence intervals (CIs). Regression splines were employed to explore potential nonlinear associations. Subgroup and sensitivity analyses were conducted to investigate the heterogeneity of IC change under specific conditions and the robustness of our results. Mediation analysis was performed to identify potential factors mediating the relationship between sleep patterns and IC change.

Results

Both excessive (>10 h) (total, ME: −1.12; 95% CI: −1.61, −0.64; nighttime, ME: −1.44; 95% CI: −2.29, −0.59) and insufficient (<6 h) sleep duration (total, ME: −0.43; 95% CI: −0.68, −0.18; nighttime, ME: −0.50; 95% CI: −0.73, −0.27) negatively impacted IC change. Moderate naps (≤60 min) mitigated the decline in IC change (ME: 0.28; 95% CI: 0.07, 0.49). IC values decreased at the slowest rate when nap time constituted one-seventh of total sleep time. The onset of dyslipidemia partially mediated the association between naps (≤60 min) and IC change (P =  0.02).

Conclusions

These findings suggest that maintaining a healthy sleep pattern of 6−8 h of nighttime or total sleep, along with a post-lunch nap of ≤60 min, helps preserve optimal IC or delay its decline. This is particularly beneficial for cognitive, psychological, and locomotion performance among middle-aged and older adults.
目的:内在能力(IC)是一个包含智力和体力的多维结构,已被世界卫生组织纳入老龄化框架。然而,IC 与中国人睡眠模式(夜间睡眠和午后小睡)之间的详细关系仍未得到充分阐明:本研究的参与者为中国健康与退休纵向研究(CHARLS)中年龄≥45岁的中国居民。我们分析了从第一波(2011 年 5 月至 2012 年 3 月)到第二波(2015 年 7 月至 2016 年 1 月)的 4 年 CHARLS 数据。这些波次的数据被用于纵向分析。自我报告的数据包括夜间睡眠和午睡时间,以及其他基线特征。集成电路评估包括体格检查和血液化验。首先,使用线性回归评估总睡眠时间、夜间睡眠时间、午睡时间和两个波次之间的 IC 变化之间的关系,这些关系由边际效应 (ME) 及其相应的 95% 置信区间 (CI) 决定。采用回归样条来探索潜在的非线性关联。为了研究特定条件下 IC 变化的异质性和结果的稳健性,我们进行了分组和敏感性分析。我们还进行了中介分析,以确定睡眠模式与集成电路变化之间关系的潜在中介因素:结果:睡眠时间过长(>10 小时)(总睡眠时间,ME:-1.12;95% CI:-1.61,-0.64;夜间睡眠时间,ME:-1.44;95% CI:-2.29,-0.59)和睡眠时间不足(>10 小时)(总睡眠时间,ME:-1.12;95% CI:-2.29,-0.59)均对 IC 变化有影响:这些研究结果表明,保持健康的睡眠模式,即 6-8 小时的夜间睡眠或全日睡眠,再加上午餐后≤60 分钟的小睡,有助于保持最佳的 IC 状态或延缓其衰退。这对中老年人的认知、心理和运动表现尤其有益。
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引用次数: 0
期刊
Journal of Nutrition Health & Aging
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