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Autonomy, disruptions and coping strategies of community-dwelling older adults in food-related activities - food shopping, cooking and eating- a scoping review 社区居住的老年人在食品相关活动中的自主性、干扰和应对策略——食品购物、烹饪和饮食——范围审查
IF 4 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-01-08 DOI: 10.1016/j.jnha.2025.100769
Hélène Trimaille , Yoshimasa Sagawa , Aline Chassagne

Background

Food-related activities—shopping, cooking, and eating—play a critical role in enabling community-dwelling older adults to live and age in place.

Objectives

This scoping review aims to explore existing knowledge on the experiences of community-dwelling older adults in their food-related activities. It also seeks to identify which stages of these activities have been studied.

Method

A systematic search of four databases (2000–2023) identified 1,189 articles. After screening, 48 studies were included. Data were analysed to determine which stages of food-related activities were examined and to extract emerging themes.

Results

Of the 48 studies, 31% addressed all three stages, 14% focused on two stages, and 54% examined one stage. This review highlights the complex interplay of social, cultural, economic, political, and health environments that structure food-related activities. Disruptions within these environments challenge autonomy. Depending on their social roles, interests, skills, and knowledge, older adults develop coping strategies to maintain control over their food-related activities.

Conclusion

The findings underscore the need for ethical, person-centered support from healthcare and social service professionals, as well as relatives. Support should respect the decision-making autonomy of older adults while offering tailored nutritional guidance that enables them to adapt their food-related activities to evolving needs.
与食物相关的活动——购物、烹饪和饮食——在使社区居住的老年人能够在适当的地方生活和衰老方面发挥着关键作用。目的:本综述旨在探讨社区居住老年人食物相关活动经验的现有知识。它还设法查明对这些活动的哪些阶段进行了研究。方法系统检索4个数据库(2000-2023),共收录1189篇文献。筛选后,纳入48项研究。对数据进行了分析,以确定审查了与粮食有关的活动的哪些阶段,并提取了新出现的主题。在48项研究中,31%的研究涉及所有三个阶段,14%的研究关注两个阶段,54%的研究关注一个阶段。这篇综述强调了社会、文化、经济、政治和健康环境之间复杂的相互作用,这些环境构成了与食物有关的活动。这些环境中的干扰挑战了自主性。根据他们的社会角色、兴趣、技能和知识,老年人会制定应对策略来控制他们与食物有关的活动。结论研究结果强调了卫生保健和社会服务专业人员以及家属需要道德的、以人为本的支持。支持应尊重老年人的决策自主权,同时提供量身定制的营养指导,使他们能够根据不断变化的需求调整与食物有关的活动。
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引用次数: 0
Dynamic changes in frailty status and the risk of incident low back pain: a nationwide cohort study based on the China health and retirement longitudinal study 虚弱状态的动态变化与腰痛发生的风险:基于中国健康与退休纵向研究的全国队列研究
IF 4 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-01-08 DOI: 10.1016/j.jnha.2026.100771
Chenfei Zhang, Yonghao Wu, Yinan Liang, Kaifeng Wang

Background

Low back pain (LBP) is a leading cause of global disability. While frailty is a known risk factor, previous studies have been largely cross-sectional, thus the impact of dynamic changes in frailty on incident LBP is unclear. This study aimed to investigate the association of changes in frailty status with incident LBP.

Methods

This prospective cohort study utilized data from the China Health and Retirement Longitudinal Study (CHARLS), including 9,174 participants aged ≥45 years without LBP at the start of follow-up. Frailty status (robust, pre-frail, frail) was determined using a 30-item Frailty Index (FI) at baseline (2011) and two years later (2013). Dynamic changes were defined by transitions between these states. Incident LBP was the primary outcome, ascertained via follow-up until 2020. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

The study included 9,174 participants (mean age 59.2 years; 47.9% female) followed for a median of 7.48 years, during which 3,437 incident LBP cases were identified. Compared with participants who remained robust, those who progressed to a pre-frail or frail status had a significantly increased risk of incident LBP (HR 1.48, 95% CI 1.32−1.66). Progression from pre-frail to frail also increased risk (HR 1.51, 95% CI 1.35−1.69) compared to remaining pre-frail. Conversely, recovery was protective; participants improving from pre-frail to robust (HR 0.69, 95% CI 0.61−0.78) or from frail to less frail status (HR 0.77, 95% CI 0.66−0.90) had significantly lower risks than their stable counterparts.

Conclusions

Frailty is a dynamic and powerful predictor of incident LBP. Progression towards frailty significantly elevates LBP risk, while recovery is protective. These findings establish a temporal relationship, positioning frailty as a critical, modifiable target for LBP prevention. Integrating frailty assessment into routine clinical care may be a key strategy to reduce the burden of LBP in aging populations.
背景:腰痛(LBP)是全球致残的主要原因。虽然虚弱是一个已知的危险因素,但以前的研究大多是横断面的,因此虚弱的动态变化对LBP事件的影响尚不清楚。本研究旨在探讨虚弱状态变化与腰痛事件的关系。方法本前瞻性队列研究利用中国健康与退休纵向研究(CHARLS)的数据,纳入9174名随访开始时年龄≥45岁、无LBP的参与者。在基线(2011年)和两年后(2013年)使用30项虚弱指数(FI)确定虚弱状态(强健、体弱、体弱)。动态变化是由这些状态之间的转换定义的。通过随访至2020年,偶发性腰痛是主要结局。采用多变量Cox比例风险模型计算风险比(hr)和95%置信区间(ci)。结果本研究纳入9174名参与者(平均年龄59.2岁,女性47.9%),随访时间中位数为7.48年,期间发现3437例LBP事件。与保持健康的参与者相比,那些进展到体弱或体弱状态的参与者发生LBP的风险显著增加(HR 1.48, 95% CI 1.32 - 1.66)。从虚弱前期到虚弱的进展也增加了风险(HR 1.51, 95% CI 1.35−1.69)。相反,复苏是保护性的;从虚弱到健壮(HR 0.69, 95% CI 0.61 - 0.78)或从虚弱到不那么虚弱(HR 0.77, 95% CI 0.66 - 0.90)的参与者的风险显著低于稳定的参与者。结论虚弱是腰痛发生的动态、有效的预测因子。虚弱的进展显著增加了腰痛的风险,而恢复是保护性的。这些发现建立了一种时间关系,将虚弱定位为预防腰痛的关键、可改变的目标。将衰弱评估纳入常规临床护理可能是减轻老年人群腰痛负担的关键策略。
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引用次数: 0
IF 4 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-01-01
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引用次数: 0
IF 4 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-01-01
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引用次数: 0
An integrative approach to detecting potential blood-based biomarkers of cognitive frailty. 一种检测潜在的基于血液的认知衰弱生物标志物的综合方法。
IF 4 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-01-01 Epub Date: 2025-11-24 DOI: 10.1016/j.jnha.2025.100726
Motoki Furutani, Mutsumi Suganuma, Tohru Hosoyama, Risa Mitsumori, Marie Takemura, Yasumoto Matsui, Yukiko Nakano, Shumpei Niida, Kouichi Ozaki, Shosuke Satake, Daichi Shigemizu

Objective: Cognitive frailty, defined by the coexistence of cognitive decline and physical frailty, has been clinically defined, but its biological clues are still vague. This underscores the need for promising blood-based molecular biomarkers.

Design: Cross-sectional observational study.

Settings and participants: Frailty was diagnosed using the Japanese version of the Cardiovascular Health Study (J-CHS), and mild cognitive impairment was assessed with the Japanese version of the Montreal Cognitive Assessment (MoCA-J) and Mini-Mental State Examination-Japanese (MMSE-J). Participants with MMSE-J ≥24, MoCA-J score ≤25, and J-CHS score ≥1 were classified as having cognitive frailty. This study included 87 older adults aged ≥65 years, comprising 44 robust and 43 with cognitive frailty.

Measurements: Blood samples and associated clinical data were obtained from the National Center for Geriatrics and Gerontology Biobank in Japan. A multi-omics analysis integrating clinical data, RNA-seq, aging-related factors, and metabolomics were conducted to identify potential biomarkers through logistic regression, adjusting for age, sex, and body mass index (BMI). An optimal set of biomarkers was determined by constructing prediction models using the random forest algorithm.

Results: Three candidate biomarkers were identified from aging-related factors-growth differentiation factor (GDF15), brain-derived neurotrophic factor (BDNF), and Adiponectin-and three from metabolomics-myristic acid, nicotinamide, and γ-butyrobetaine. Using combinations of these candidates with clinical variables, we constructed risk prediction models. The best model incorporated one aging-related factors (GDF15) and two metabolites (myristic acid, and nicotinamide), achieving a high area under the receiver operating characteristic curve (AUC) of 0.96 in an independent validation cohort. This was significantly higher than models based solely on clinical information (age, sex, and BMI) (Welch's t-test, p <0.001). Among these biomarkers, myristic acid showed the highest influence, with a median Gini importance of 0.38 (95% confidence interval: 0.29-0.47).

Conclusions: We identified three promising biomarkers-GDF15, myristic acid, and nicotinamide-for cognitive frailty. Notably, low plasma myristic acid levels emerged as the most significant contributor to the prediction model. Further refinement and large-scale validation will be essential to support its future clinical application.

目的:认知衰弱是指认知能力下降和身体虚弱并存的一种症状,临床上已对其进行了明确的定义,但其生物学线索尚不明确。这强调了对有前途的血液分子生物标志物的需求。设计:横断面观察性研究。环境和参与者:使用日文版心血管健康研究(J-CHS)诊断虚弱,使用日文版蒙特利尔认知评估(MoCA-J)和日本迷你精神状态检查(MMSE-J)评估轻度认知障碍。MMSE-J≥24、MoCA-J评分≤25、J-CHS评分≥1者为认知衰弱。本研究纳入87例年龄≥65岁的老年人,包括44例健全人和43例认知衰弱者。测量方法:血液样本和相关临床数据来自日本国家老年医学中心和老年医学生物库。结合临床数据、RNA-seq、衰老相关因素和代谢组学进行多组学分析,通过logistic回归,调整年龄、性别和体重指数(BMI),确定潜在的生物标志物。利用随机森林算法构建预测模型,确定一组最优的生物标志物。结果:从衰老相关因子中鉴定出3个候选生物标志物——生长分化因子(GDF15)、脑源性神经营养因子(BDNF)和脂联素;从代谢组学中鉴定出3个候选生物标志物——肉豆蔻酸、烟酰胺和γ-丁甜菜碱。通过将这些候选者与临床变量相结合,我们构建了风险预测模型。最佳模型包含1个衰老相关因子(GDF15)和2个代谢物(肉豆蔻酸和烟酰胺),在独立验证队列中获得了0.96的受试者工作特征曲线下面积(AUC)。这明显高于仅基于临床信息(年龄、性别和BMI)的模型(Welch’st检验,p)。结论:我们确定了三种有前景的生物标志物——gdf15、肉豆酱酸和烟酰胺——用于认知衰弱。值得注意的是,低血浆肉豆蔻酸水平是预测模型中最重要的贡献者。进一步的改进和大规模验证对于支持其未来的临床应用至关重要。
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引用次数: 0
Krill Oil Supplementation and Muscle Health in Older Age: Broad Benefits Without Boundaries? 补充磷虾油和老年肌肉健康:广泛的益处没有界限?
IF 4 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-26 DOI: 10.1016/j.jnha.2025.100767
Riccardo Calvani , Emanuele Marzetti , Anna Picca
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引用次数: 0
Hearing impairment detected by the whisper test is associated with physio-cognitive decline syndrome in community-dwelling older adults 在社区居住的老年人中,耳语测试检测到的听力损伤与生理认知衰退综合征有关
IF 4 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-20 DOI: 10.1016/j.jnha.2025.100758
Li Zhang , Yiwen Xing , Yiming Pan , Yiwei Zhao , Zhibin Wang , Yue Wu , Xue Gao , Xiaxia Li , Yu Wang , Yumin Wang , Yansu Guo , Yi Tang , Lina Ma

Objective

To explore the association between hearing impairment, as detected by the whisper test, and physio-cognitive decline syndrome (PCDS) in older adults.

Design

Cross-sectional study.

Setting

Community.

Participants

Data were derived from the Beijing Disability Risk and Ageing Monitoring Study (BEAM), including 1,117 community-dwelling older adults. PCDS was defined as the concurrent presence of mobility impairment no disability (MIND) and cognitive impairment no dementia (CIND). Mobility impairment was defined as weakness and/or slowness, while cognitive impairment was defined as performance below 1.5 standard deviations in any cognitive domain, adjusted for age and education.

Results

The prevalence of PCDS was 14.50%. Compared with older adults in the non-PCDS group, participants with PCDS were older, had lower educational level, experienced more chronic diseases, took more medications, and exhibited a higher prevalence of hearing impairment as detected by the whisper test. In terms of mobility and cognition, participants with PCDS demonstrated slower gait speed, weaker grip strength, and lower scores on the Mini-Mental State Examination, particularly in the domains of immediate memory, delayed memory, and attention and computation. After adjusting for confounders, multivariate logistic regression analysis showed that hearing impairment detected by the whisper test was significantly associated with PCDS (odds ratio = 2.121, 95% confidence interval: 1.009–1.459) when compared to the non-PCDS group.

Conclusion

Hearing impairment, as identified by the whisper test, is closely correlated with PCDS in community-dwelling older adults. The comprehensive management of older adults should not only focus on general conditions such as educational level and medication use, but also pay attention to functional status such as hearing, in order to screen for PCDS in the early stage and delay function decline.
目的探讨老年人耳语测验(耳语测验)检测的听力障碍与生理认知能力下降综合征(PCDS)的关系。数据来源于北京残疾风险和老龄化监测研究(BEAM),包括1117名居住在社区的老年人。PCDS被定义为同时存在行动障碍无残疾(MIND)和认知障碍无痴呆(CIND)。行动障碍被定义为虚弱和/或行动迟缓,而认知障碍被定义为在任何认知领域的表现低于1.5个标准差,并根据年龄和教育程度进行调整。结果PCDS患病率为14.50%。与非PCDS组的老年人相比,患有PCDS的参与者年龄较大,受教育程度较低,经历过更多的慢性疾病,服用了更多的药物,并且通过耳语测试检测出听力障碍的患病率更高。在活动能力和认知能力方面,PCDS患者表现出步态速度较慢、握力较弱、迷你精神状态检查得分较低,特别是在即时记忆、延迟记忆、注意力和计算方面。在调整混杂因素后,多因素logistic回归分析显示,与非PCDS组相比,耳语测试检测到的听力障碍与PCDS显著相关(优势比= 2.121,95%置信区间:1.009-1.459)。结论在社区居住的老年人中,低语声测试所识别的听力障碍与PCDS密切相关。老年人的综合管理不仅要关注教育水平、用药等一般情况,还要关注听力等功能状态,以便早期筛查PCDS,延缓功能衰退。
{"title":"Hearing impairment detected by the whisper test is associated with physio-cognitive decline syndrome in community-dwelling older adults","authors":"Li Zhang ,&nbsp;Yiwen Xing ,&nbsp;Yiming Pan ,&nbsp;Yiwei Zhao ,&nbsp;Zhibin Wang ,&nbsp;Yue Wu ,&nbsp;Xue Gao ,&nbsp;Xiaxia Li ,&nbsp;Yu Wang ,&nbsp;Yumin Wang ,&nbsp;Yansu Guo ,&nbsp;Yi Tang ,&nbsp;Lina Ma","doi":"10.1016/j.jnha.2025.100758","DOIUrl":"10.1016/j.jnha.2025.100758","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the association between hearing impairment, as detected by the whisper test, and physio-cognitive decline syndrome (PCDS) in older adults.</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Setting</h3><div>Community.</div></div><div><h3>Participants</h3><div>Data were derived from the Beijing Disability Risk and Ageing Monitoring Study (BEAM), including 1,117 community-dwelling older adults. PCDS was defined as the concurrent presence of mobility impairment no disability (MIND) and cognitive impairment no dementia (CIND). Mobility impairment was defined as weakness and/or slowness, while cognitive impairment was defined as performance below 1.5 standard deviations in any cognitive domain, adjusted for age and education.</div></div><div><h3>Results</h3><div>The prevalence of PCDS was 14.50%. Compared with older adults in the non-PCDS group, participants with PCDS were older, had lower educational level, experienced more chronic diseases, took more medications, and exhibited a higher prevalence of hearing impairment as detected by the whisper test. In terms of mobility and cognition, participants with PCDS demonstrated slower gait speed, weaker grip strength, and lower scores on the Mini-Mental State Examination, particularly in the domains of immediate memory, delayed memory, and attention and computation. After adjusting for confounders, multivariate logistic regression analysis showed that hearing impairment detected by the whisper test was significantly associated with PCDS (odds ratio = 2.121, 95% confidence interval: 1.009–1.459) when compared to the non-PCDS group.</div></div><div><h3>Conclusion</h3><div>Hearing impairment, as identified by the whisper test, is closely correlated with PCDS in community-dwelling older adults. The comprehensive management of older adults should not only focus on general conditions such as educational level and medication use, but also pay attention to functional status such as hearing, in order to screen for PCDS in the early stage and delay function decline.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"30 2","pages":"Article 100758"},"PeriodicalIF":4.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145798820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adherence to the Mediterranean Diet and frailty criteria in an old population with metabolic syndrome: A cross-sectional analysis 老年代谢综合征患者坚持地中海饮食和虚弱标准:横断面分析
IF 4 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-17 DOI: 10.1016/j.jnha.2025.100757
Macarena Torrego-Ellacuría , Federico Cuesta-Triana , María Ortiz-Ramos , Miguel Ángel Martínez-González , Dolores Corella , Héctor Vázquez-Lorente , Montserrat Fitó , José Alfredo Martínez , Lucas Tojal-Sierra , Julia Wärnberg , Jesús Vioque , Dora Romaguera , José López-Miranda , Ramon Estruch , Francisco J Tinahones , José Manuel Santos-Lozano , J. Luís Serra-Majem , Aurora Bueno-Cavanillas , Josep A. Tur , Juan Carlos Romero Vigara , Pilar Matía-Martín

Objectives

Frailty has emerged as a key indicator of biological aging. This study aimed to assess the relationship between MedDiet adherence and frailty prevalence in the context of metabolic syndrome (MetS).

Design

Cross-sectional study. Baseline data from PREDIMED-Plus trial

Setting

Primary care health, 23 recruitment sites (2013–2016).

Participants

A total of 6874 participants with overweight/obesity and ≥3 MetS components.

Measurements

Adherence to the MedDiet: 17-item MedDiet score. Frailty and prefrailty (3 or 1–2 criteria): modified Fried Frailty Index (FFI), considering exhaustion, physical activity and functional capacity. Main independent variable was analysed: as a continuous variable (range: 0–17); in quartiles of adherence using univariate and multivariate logistic regression models adjusted for potential confounders.

Results

Prefrailty and frailty prevalence were 49.7% and 2.9%, respectively. Compared to those with the lowest MedDiet adherence (0–6), participants with the highest adherence (11–17) had significantly lower odds of meeting frailty criteria. Fully adjusted models showed ORs of 0.479 (p = 0.097) for frailty, 0.705 (p = 0.001) for prefrailty, and 0.694 (p = 0.001) for frailty or prefrailty in participants with higher/greater MedDiet adherence. Each 1-point increase in the 17-item score was associated with an OR ranging from 0.878 to 0.977 (p < 0.05 for all comparisons, except functional capacity: p = 0.100). When adherence was dichotomized, the adjusted ORs ranged from 0.406 to 0.834 (p < 0.05 for all comparisons).

Conclusions

Higher adherence to MedDiet was associated with a lower prevalence of frailty and prefrailty in older adults with overweight/obesity and MetS, reinforcing its potential role in promoting healthy aging despite cardiometabolic comorbidities.
目的:虚弱已成为生物衰老的一个关键指标。本研究旨在评估代谢综合征(MetS)背景下MedDiet依从性与虚弱患病率之间的关系。设计:横断面研究。PREDIMED-Plus试验的基线数据设置:初级保健卫生,23个招募点(2013-2016)。参与者:共有6874名超重/肥胖且≥3个MetS成分的参与者。测量:坚持MedDiet: 17项MedDiet评分。虚弱和脆弱(3或1-2个标准):改良的Fried虚弱指数(FFI),考虑疲劳、身体活动和功能能力。分析主自变量:作为连续变量(取值范围:0-17);使用单变量和多变量逻辑回归模型对潜在混杂因素进行调整。结果:患病率为49.7%,虚弱患病率为2.9%。与最低MedDiet依从性(0-6)的参与者相比,最高依从性(11-17)的参与者符合虚弱标准的几率显着降低。完全调整后的模型显示,体质虚弱的or值为0.479 (p = 0.097),体质虚弱的or值为0.705 (p = 0.001), MedDiet依从性较高或更强的受试者体质虚弱或体质虚弱的or值为0.694 (p = 0.001)。17项得分每增加1分,OR值范围为0.878 ~ 0.977(除功能能力外,所有比较p < 0.05)。当依从性进行二分类时,调整后的or范围为0.406 ~ 0.834(所有比较p < 0.05)。结论:MedDiet的高依从性与超重/肥胖和MetS的老年人中较低的虚弱和易感患病率相关,这加强了MedDiet在促进心脏代谢合并症的健康衰老方面的潜在作用。
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引用次数: 0
Lycopene, Race and Periodontitis: Disparities in Older Adults 番茄红素,种族和牙周炎:老年人的差异
IF 4 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-13 DOI: 10.1016/j.jnha.2025.100759
Katherine Kwong , You Lu , ZhuoHuan Li , Susu Luo , Zhaoyu Huang , Zhong Chen , Na Zhao , Tung-Sung Tseng

Background

Periodontitis is a severe gum disease that can be an indicator of other health conditions such as cardiovascular disease and diabetes. Lycopene has been suggested as an adjunct therapy for periodontitis. This study aims to investigate the association between insufficient lycopene intake and the risk of Periodontitis among non-Hispanic White (NHW) and non-Hispanic Black (NHB) older adults.

Methods

The study included 1,227 adults aged 65–79 years from the National Health and Nutritional Examination Survey (2009–2014). Total lycopene intake from daily diet was studied with age, race, marital status, smoking status, BMI, diabetes, sex, and education as independent variables in regression model.

Results

Overall, 48.7% of the older adults exhibited varying degrees of PD, and 49.1% had insufficient dietary lycopene intake. Adequate lycopene intake was associated with a reduced likelihood of severe PD (odds ratio (O.R.): 0.33; 95%CI: 0.17−0.65). NHBs were more prone to developing severe PD compared to NHWs (O.R.: 2.82, 95%CI: 1.46−5.45). Women exhibiting a lower likelihood of severe PD than men (O.R.: 0.27; 95% CI: 0.14−0.55). NHW females, who were less likely to have severe PD compared to NHW males (O.R.: 0.26; 95% CI: 0.12−0.56).

Conclusion

Dietary lycopene intake is associated with reduced risk of severe PD, particularly in NHW individuals over 65 years old. PD was more common in men and NHB individuals, with a latter group showing a higher prevalence of severe PD. Our results suggest that future PD prevention strategies should consider targeted, race-and sex-specific dietary interventions.
背景牙周炎是一种严重的牙龈疾病,可以作为其他健康状况的指标,如心血管疾病和糖尿病。番茄红素已被建议作为牙周炎的辅助治疗。本研究旨在调查非西班牙裔白人(NHW)和非西班牙裔黑人(NHB)老年人番茄红素摄入量不足与牙周炎风险之间的关系。方法选取2009-2014年全国健康与营养调查中1227名65 ~ 79岁的成年人为研究对象。以年龄、种族、婚姻状况、吸烟状况、体重指数、糖尿病、性别、教育程度为自变量的回归模型研究每日饮食中番茄红素的总摄入量。结果总体而言,48.7%的老年人表现出不同程度的PD, 49.1%的老年人饮食中番茄红素摄入量不足。充足的番茄红素摄入量与严重PD的可能性降低相关(优势比:0.33;95%置信区间:0.17−0.65)。nhb比nhw更容易发展为严重PD (O.R: 2.82, 95%CI: 1.46−5.45)。女性患严重PD的可能性低于男性(O.R: 0.27; 95% CI: 0.14 - 0.55)。与NHW男性相比,NHW女性患严重PD的可能性更小(比值比:0.26;95% CI: 0.12 - 0.56)。结论:饮食中番茄红素的摄入与严重PD的风险降低有关,特别是在65岁以上的NHW患者中。PD在男性和NHB个体中更为常见,后者显示出更高的严重PD患病率。我们的研究结果表明,未来的PD预防策略应该考虑有针对性的、针对种族和性别的饮食干预。
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引用次数: 0
Associations between dietary patterns and the incidence of idiopathic pulmonary fibrosis: A cohort study 饮食模式与特发性肺纤维化发病率之间的关系:一项队列研究
IF 4 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-12 DOI: 10.1016/j.jnha.2025.100755
Yonghao Li , Xinran Dou , Hui Li , Xuan Li , Luqin Yang , Jiawei Chen , Fengqin Zhang , Huihui Yue , Ruihan Dong , Jianhan He , Xuewen Wang , Wei Wei , Li Liu , Huilan Zhang

Background

Idiopathic pulmonary fibrosis (IPF) is a progressive, age-related lung disease with few modifiable risk factors. While healthy dietary patterns have been associated with reduced risk of chronic diseases, their impact on IPF remains unclear. This study investigated the relationship between adherence to healthy dietary patterns and incident IPF and explored whether phenotypic age acceleration mediates this association.

Methods

We analyzed 196,473 participants from the UK Biobank. Dietary intake was assessed via repeated 24 -h recall questionnaires, and adherence scores were calculated for the DASH, MEDAS, and MIND dietary patterns. Cox proportional hazards models were used to estimate the association between dietary scores and incident IPF. Mediation analysis was conducted to examine the role of phenotypic age acceleration.

Results

During a median follow-up of 12.4 years, 516 IPF cases were identified. Higher adherence to all three dietary patterns was significantly associated with a reduced risk of IPF. In fully adjusted models, hazard ratios for the highest vs. lowest quartiles were 0.75 (95% CI: 0.59–0.95) for DASH, 0.53 (0.37–0.75) for MEDAS, and 0.66 (0.51–0.86) for MIND. Phenotypic age acceleration partially mediated these associations.

Conclusions

Higher dietary scores were associated with a lower risk of incident IPF, partially mediated by reduced phenotypic age acceleration. These findings suggest that promoting healthy eating habits may contribute to reducing age-related lung disease burden in older adults.
背景:特发性肺纤维化(IPF)是一种进行性、与年龄相关的肺部疾病,几乎没有可改变的危险因素。虽然健康的饮食模式与降低慢性疾病的风险有关,但其对IPF的影响仍不清楚。本研究调查了坚持健康饮食模式与IPF发生率之间的关系,并探讨了表型年龄加速是否介导了这种关联。方法我们分析了来自英国生物银行的196,473名参与者。通过重复的24小时回忆问卷评估饮食摄入量,并计算DASH、MEDAS和MIND饮食模式的依从性得分。使用Cox比例风险模型来估计饮食评分与IPF事件之间的关系。通过中介分析来检验表型年龄加速的作用。结果在中位随访12.4年期间,共发现516例IPF病例。坚持三种饮食模式与降低IPF风险显著相关。在完全调整的模型中,DASH最高和最低四分位数的风险比为0.75 (95% CI: 0.59-0.95), MEDAS为0.53 (0.37-0.75),MIND为0.66(0.51-0.86)。表型年龄加速部分介导了这些关联。结论较高的饮食评分与较低的IPF发生风险相关,部分原因是表型年龄加速减少。这些发现表明,促进健康的饮食习惯可能有助于减少老年人与年龄相关的肺部疾病负担。
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引用次数: 0
期刊
Journal of Nutrition Health & Aging
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