Journal of Nutrition Health & Aging最新文献

{"title":"Daily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults in a randomized, parallel arm, double-blind, placebo-controlled, pilot study","authors":"Brianna J. Stubbs ,&nbsp;Elizabeth B. Stephens ,&nbsp;Chatura Senadheera ,&nbsp;Sawyer Peralta ,&nbsp;Stephanie Roa-Diaz ,&nbsp;Laura Alexander ,&nbsp;Wendie Silverman-Martin ,&nbsp;Thelma Y. Garcia ,&nbsp;Michi Yukawa ,&nbsp;Jenifer Morris ,&nbsp;Traci M. Blonquist ,&nbsp;James B. Johnson ,&nbsp;John C. Newman","doi":"10.1016/j.jnha.2024.100329","DOIUrl":"10.1016/j.jnha.2024.100329","url":null,"abstract":"<div><h3>Objectives</h3><p>Ketone bodies are endogenous metabolites produced during fasting or a ketogenic diet that have pleiotropic effects on aging pathways. Ketone esters (KEs) are compounds that induce ketosis without dietary changes, but KEs have not been studied in an older adult population. The primary objective of this trial was to assess the tolerability and safety of KE ingestion in a cohort of older adults.</p></div><div><h3>Design</h3><p>Randomized, placebo-controlled, double-blinded, parallel-arm trial (NCT05585762).</p></div><div><h3>Setting</h3><p>General community, Northern California, USA.</p></div><div><h3>Participants</h3><p>Community-dwelling older adults, independent in activities of daily living, with no unstable acute medical conditions (n = 30; M = 15, F = 15; age = 76 y, range 65–90 y) were randomized and n = 23 (M = 14, F = 9) completed the protocol.</p></div><div><h3>Intervention</h3><p>Participants were randomly allocated to consume either KE (25 g bis-octanoyl (R)-1,3-butanediol) or a taste, appearance, and calorie-matched placebo (PLA) containing canola oil daily for 12 weeks.</p></div><div><h3>Measurements</h3><p>Tolerability was assessed using a composite score from a daily log for 2-weeks, and then via a bi-weekly phone interview. Safety was assessed by vital signs and lab tests at screening and weeks 0, 4 and 12, along with tabulation of adverse events.</p></div><div><h3>Results</h3><p>There was no difference in the prespecified primary outcome of proportion of participants reporting moderate or severe nausea, headache, or dizziness on more than one day in a two-week reporting period (KE n = 2 (14.3% [90% CI = 2.6–38.5]); PLA n = 1 (7.1% [90% CI = 0.4–29.7]). Dropouts numbered four in the PLA group and two in the KE group. A greater number of symptoms were reported in both groups during the first two weeks; symptoms were reported less frequently between 2 and 12 weeks. There were no clinically relevant changes in safety labs or vital signs in either group.</p></div><div><h3>Conclusions</h3><p>This KE was safe and well-tolerated in this study of healthy older adults. These results provide an initial foundation for use of KEs in clinical research with older adults.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100329"},"PeriodicalIF":4.3,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004160/pdfft?md5=d1ff78b8a8ab1a599816c22096ac2f48&pid=1-s2.0-S1279770724004160-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141964636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serial gait speed measurements over time and dynamic survival prediction in older adults","authors":"Subashan Perera ,&nbsp;Xiao Zhang ,&nbsp;Charity G. Patterson ,&nbsp;Robert M. Boudreau","doi":"10.1016/j.jnha.2024.100330","DOIUrl":"10.1016/j.jnha.2024.100330","url":null,"abstract":"<div><h3>Background</h3><p>A one-time gait speed measurement predicts mortality risk. A framework for updating a clinician’s mortality risk perception with new information from each clinic visit is needed. We used joint modeling of longitudinal and survival data for dynamic prediction of mortality risk.</p></div><div><h3>Methods</h3><p>We fit sex-stratified joint models to 20-meter (bi)annual longitudinal gait speed measured every 6 months and 14-year survival data from the Health, Aging and Body Composition Study allowing for non-linear fluctuations of gait speed and controlling for important covariates such as age, recent hospitalization, blood pressure, obesity, and comorbidities.</p></div><div><h3>Results</h3><p>Participants (N = 3048) were 74 years old with gait speed 1.18 m/s. They were 42% Black, and 52% died over 14 years. Higher gait speed of 0.1 m/s was associated with 23% (95% confidence interval or CI = 20–25%) and 25% (CI = 21–28%) reductions in mortality risk in men and women; and a 0.05 m/s annualized slowing (slope) with 31% (CI = 13–51%) increase in men (all p &lt; 0.05), with findings persisting after covariate adjustment. Distant gait speed history over a year prior contributed little for mortality risk prediction with mean change of only 1–2% in 5-year risk.</p></div><div><h3>Conclusion</h3><p>The two most recent gait speeds appear sufficient to consider for mortality risk in the present initial analysis. More frequent gait speeds need to be considered in mortality risk prediction before definitive conclusions supporting real-world application.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100330"},"PeriodicalIF":4.3,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004172/pdfft?md5=29a1c540a065a054c2a28cf6eb202c0a&pid=1-s2.0-S1279770724004172-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between fruit and vegetable intake and depression: evidence from genetic studies","authors":"Yifan Zhang,&nbsp;Ruijun Chen,&nbsp;Yuexin Yan,&nbsp;Shengyuan Su","doi":"10.1016/j.jnha.2024.100332","DOIUrl":"10.1016/j.jnha.2024.100332","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100332"},"PeriodicalIF":4.3,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004196/pdfft?md5=b59e5579bce190fe31e921c2be778f69&pid=1-s2.0-S1279770724004196-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Effect of Information and Communication Technology-based Smart Care Services for Physical and Cognitive Functions in Older Adults Living Alone: A Quasi-experimental Study” [The Journal of Nutrition, Health and Aging 28 (2024) 100318]","authors":"Du-Ri Kim ,&nbsp;Ting-Fu Lai ,&nbsp;Minji Sung ,&nbsp;Minwoo Jang ,&nbsp;Yeo-Kyung Shin ,&nbsp;Young Jin Ra ,&nbsp;Yung Liao ,&nbsp;Jong-Hwan Park ,&nbsp;Myung-Jun Shin","doi":"10.1016/j.jnha.2024.100326","DOIUrl":"10.1016/j.jnha.2024.100326","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100326"},"PeriodicalIF":4.3,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004135/pdfft?md5=7f8f83592775d669541191f493232732&pid=1-s2.0-S1279770724004135-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional association of food insecurity with loneliness in older adults: The role of sex, age, and psychosomatic factors","authors":"Razak M. Gyasi ,&nbsp;Emelia Aikins ,&nbsp;André Hajek ,&nbsp;Jones Opoku-Ware ,&nbsp;Benjamin Appiah Osei ,&nbsp;Joana Kwabena-Adade ,&nbsp;Louis Jacob ,&nbsp;Masoud Rahmati ,&nbsp;George Dakurah ,&nbsp;Karl Peltzer","doi":"10.1016/j.jnha.2024.100328","DOIUrl":"10.1016/j.jnha.2024.100328","url":null,"abstract":"<div><h3>Objective</h3><p>Food insecurity (FI) is a critical social determinant of poor psychosocial health. While data on the specific roles of sex and age in the FI-loneliness link among older adults are limited, the underlying mechanisms are largely unknown. This study examines the age-sex-specific associations of FI with loneliness among older adults in Ghana and quantifies the extent to which psychosomatic factors mediate the association.</p></div><div><h3>Methods</h3><p>We analyzed cross-sectional data from the Aging, Health, Psychological, and Health-seeking Behavior Study in Ghana. The past 30-day FI was assessed using items on hunger and breakfast skipping frequency due to a lack of resources. We assessed loneliness severity with the University of California, Los Angeles 3-item Loneliness Scale. Multivariable OLS regressions and bootstrapping mediation analysis using the Hayes PROCESS macro plug-in were used to evaluate the associations.</p></div><div><h3>Results</h3><p>We included 1,201 individuals aged ≥50 years (mean = 62.9 [SD = 11.9]; women = 63.3%). The prevalence of loneliness was 17.7%. The prevalence of moderate and severe FI was 44.0% and 8.5%, respectively. In the adjusted model, greater FI was significantly associated with loneliness severity (<em>B</em> = .22, <em>SE</em> = .029, <em>p</em> &lt; .001). We found significant interactive effects of FI × age (<em>B</em> = −.17, <em>SE</em> = .023, <em>p</em> &lt; .01) and FI × sex (<em>B</em> = −.28, <em>SE</em> = .036, <em>p</em> &lt; .001) on loneliness. Thus, the FI-loneliness link was respectively more marked among women (<em>B</em> = .25, <em>SE</em> = .035, <em>p</em> &lt; .001) and ≥65 age groups (<em>B</em> = .34, <em>SE</em> = .041, <em>p</em> &lt; .001) than men (<em>B</em> = .16, <em>SE</em> = .051, <em>p</em> &lt; .01) and those aged 50−64 (<em>B</em> = .22; <em>SE</em> = .040, <em>p</em> &lt; .001). Finally, comorbid depression/anxiety (41.07%), hopelessness (48.6%), worthlessness (42.1%), functional limitations (8.2%), and pain severity (6.4%) mediated the FI-loneliness association.</p></div><div><h3>Conclusions</h3><p>Age- and sex-specific associations between FI and loneliness exist among older Ghanaians. Addressing FI in concert with psychosomatic problems in older adults may contribute meaningfully to reducing loneliness in later life.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100328"},"PeriodicalIF":4.3,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004159/pdfft?md5=7e76edb2aa3c9418fbb56524ee1ff274&pid=1-s2.0-S1279770724004159-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Uric Acid Levels Associated with Outcomes of Neurodegenerative Disorders and Brain Health: Findings from the UK Biobank","authors":"Zihao Jiang ,&nbsp;Jieyu Chen ,&nbsp;Siqi Wu ,&nbsp;Shuai Ji ,&nbsp;Ying Yang ,&nbsp;Wen Fang ,&nbsp;Ziwei Li ,&nbsp;Jingxin Lin ,&nbsp;Jie Chen ,&nbsp;Chuanghai Wu ,&nbsp;Hiu Yee Kwan ,&nbsp;Yigui Lai ,&nbsp;Xiaoshan Zhao","doi":"10.1016/j.jnha.2024.100319","DOIUrl":"10.1016/j.jnha.2024.100319","url":null,"abstract":"<div><h3>Background</h3><p>The relationship between serum uric acid (SUA) levels and brain-related health remains uncertain.</p></div><div><h3>Objectives</h3><p>This study aimed to investigate the relationship between SUA levels and some neurodegenerative disorders and brain structure.</p></div><div><h3>Design</h3><p>A longitudinal study.</p></div><div><h3>Setting and participants</h3><p>384,517 participants who did not have stroke, dementia, and Parkinsonism, with complete urate testes and covariates were included.</p></div><div><h3>Measurements</h3><p>Cox proportional hazards models, competing risk models, and restricted cubic spine models were applied.</p></div><div><h3>Results</h3><p>During the median follow-up time of 12.7 years (interquartile range [IQR]:12.0, 13.5), 7821 (2.0%) participants developed stroke, 5103 (1.3%) participants developed dementia, and 2341 (0.6%) participants developed Parkinsonism. Nonlinear relationships were identified between SUA levels and stroke (J-shaped), dementia, and Parkinsonism (U-shaped). SUA levels of 4.2 mg/dl, 6.4 mg/dl, and 6.6 mg/dl yielded the lowest risk of stroke, dementia, and Parkinsonism, respectively. Besides, we found high SUA levels reduced the volumes of total brain, grey matter, white matter, grey matter in the hippocampus, and hippocampus, but increased lateral-ventricle volume. Inflammation accounted for 9.1% and 10.0% in the association of SUA with stroke and lateral-ventricle volume.</p></div><div><h3>Conclusions</h3><p>Lower SUA levels increased the risk of Parkinsonism, while both lower and higher SUA levels were positively associated with increased risk of stroke and dementia. Moreover, high SUA levels reduced brain structure volumes. Our findings suggest the association between SUA levels and brain-related disorders and highlight the importance of SUA management.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100319"},"PeriodicalIF":4.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004068/pdfft?md5=a49e566f442b46f6743377d1ebf272aa&pid=1-s2.0-S1279770724004068-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity and aging: advances in research and clinical practice","authors":"Philipe de Souto Barreto","doi":"10.1016/j.jnha.2024.100336","DOIUrl":"10.1016/j.jnha.2024.100336","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 8","pages":"Article 100336"},"PeriodicalIF":4.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004238/pdfft?md5=ff0168c8d269f6700e1c944e2bf52292&pid=1-s2.0-S1279770724004238-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142039602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic targets for muscle weakness in older adults: proteome-wide Mendelian randomization and colocalization analyses","authors":"Shuai-Kang Wang ,&nbsp;Qi-Jun Wang ,&nbsp;Xuan Zhao ,&nbsp;Peng Wang ,&nbsp;Xiang-Yu Li ,&nbsp;Wei Wang ,&nbsp;Shi-Bao Lu","doi":"10.1016/j.jnha.2024.100325","DOIUrl":"10.1016/j.jnha.2024.100325","url":null,"abstract":"<div><h3>Background</h3><p>Recent research highlights the importance of muscular strength as a key factor in physical fitness, a strong indicator of overall mortality risk, and a vital target for preventing chronic diseases. This study used a proteome-wide Mendelian randomization analysis plus colocalization analysis for low hand grip strength to explore potential therapeutic targets for muscle weakness.</p></div><div><h3>Methods</h3><p>We conducted two two-sample Mendelian randomization analyses from four cohorts to identify and validate the causal relationship between plasma proteins and low grip strength. We also employed bidirectional Mendelian randomization analysis with Steiger filtering, Bayesian co-localization, and phenotype scanning to detect reverse causality, thereby consolidating our Mendelian randomization findings. Downstream analyses were also undertaken of identified proteins, including knockout models, enrichment analyses, and protein-protein interaction networks. Finally, we assessed the druggability of the identified proteins.</p></div><div><h3>Results</h3><p>At Bonferroni significance (P &lt; 6.82 × 10⁻⁵), Mendelian randomization analysis revealed that three proteins were causally associated with low grip strength. Increased MGP (OR = 0.85) and HP (OR = 0.96) decreased the risk of low grip strength, whereas elevated ART4 (OR = 1.06) increased the risk of low grip strength. None of the three proteins had reverse causality with low grip strength. Bayesian co-localization suggested that MGP shared the same variant with low grip strength (coloc.abf-PPH4 = 0.826). Further downstream analyses showed that MGP, which is highly expressed in musculoskeletal system, is a potential novel target for muscle weakness.</p></div><div><h3>Conclusions</h3><p>The proteome-wide Mendelian randomization investigation identified three proteins associated with the risk of muscle weakness. MGP, HP, and ART4 deserve further investigation as potential therapeutic targets for muscle weakness.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100325"},"PeriodicalIF":4.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004123/pdfft?md5=27aade60444a45727b9127a91e5e0986&pid=1-s2.0-S1279770724004123-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of visceral adiposity index with phenotypic age acceleration: insight from NHANES 1999–2010","authors":"Cheng Xu ,&nbsp;Zhen Song ,&nbsp;Jia-ni Wang ,&nbsp;Chong-chao Li","doi":"10.1016/j.jnha.2024.100323","DOIUrl":"10.1016/j.jnha.2024.100323","url":null,"abstract":"<div><h3>Background</h3><p>Obesity correlates with accelerated aging. This study aims to investigate the association between the visceral adiposity index (VAI) and accelerated aging.</p></div><div><h3>Methods</h3><p>Biological aging was evaluated by phenotypic age acceleration (PhenoAgeAccel). Utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2010, we employed weighted multivariable logistic regression models, along with subgroup analysis, to examine the association between VAI and PhenoAgeAccel. Moreover, smooth curve fitting was utilized to identify potential nonlinear association, complemented by a two-piece linear regression model to investigate threshold effects.</p></div><div><h3>Results</h3><p>Of the included 11,340 participants aged 20 years and older, the mean (95% CI) age was 46.569 (45.946, 47.191) years, and 49.189% were male. The mean (95% CI) VAI for all participants was 2.176 (2.114, 2.238), and the mean (95% CI) PhenoAgeAccel was −6.306 (−6.618, −5.994) years. In the fully adjusted model, each incremental unit increase of VAI was associated with a 0.312-year increase in PhenoAgeAccel (β = 0.312, 95% CI: 0.217, 0.408). This positive association was more statistically significant among individuals with cancer. Furthermore, a segmented association was observed between VAI and PhenoAgeAccel, with a turning point identified at 10.543. Below this threshold, VAI exhibited a positive correlation with PhenoAgeAccel (β = 0.617, 95% CI: 0.499, 0.735), while beyond it, the association became nonsignificant.</p></div><div><h3>Conclusion</h3><p>This study demonstrated a positive association between VAI and accelerated aging within a nationally representative population. The findings suggest that controlling adiposity may exert anti-aging effects and help prevent aging-related diseases.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100323"},"PeriodicalIF":4.3,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S127977072400410X/pdfft?md5=db025a6ca92e591423f7244c02d260df&pid=1-s2.0-S127977072400410X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical performance changes as clues to late-life blood pressure changes with advanced age: the osteoporotic fractures in men study","authors":"Deepika R. Laddu ,&nbsp;Hajwa Kim ,&nbsp;Peggy M. Cawthon ,&nbsp;Michael J. LaMonte ,&nbsp;Shane A. Phillips ,&nbsp;Jun Ma ,&nbsp;Marcia L. Stefanick","doi":"10.1016/j.jnha.2024.100317","DOIUrl":"10.1016/j.jnha.2024.100317","url":null,"abstract":"<div><h3>Objectives</h3><p>This study examined whether changes in late-life physical performance are associated with contemporaneous changes in blood pressure (BP) in older men.</p></div><div><h3>Design</h3><p>prospective cohort study over 7 years.</p></div><div><h3>Setting and Participants</h3><p>Physical performance (gait speed, grip strength, chair stand performance) and clinic-measured BP at baseline and at least one follow-up (year 7 or 9) were assessed in 3,135 men aged ≥65 y enrolled in the Osteoporotic Fractures in Men Study (MrOS).</p></div><div><h3>Methods</h3><p>Generalized estimating equation analysis of multivariable models with standardized point estimates (β [95% CI]) described longitudinal associations between physical performance and BP changes in participants overall, and stratified by baseline cardiovascular disease (CVD), antihypertensive medication use (none, ≥1), and enrollment age (&lt;75 years; ≥75 years).</p></div><div><h3>Results</h3><p>Overall, positive associations (z-score units) were found between each increment increase in gait speed and systolic (SBP) (0.74 [0.22, 1.26]) and grip strength (0.35 [0.04, 0.65]) or gait speed (0.55 [0.24, 0.85]) with diastolic (DBP). Better grip strength and chair stand performance over time were associated with 1.83 [0.74, 2.91] and 3.47 [0.20, 6.74] mmHg higher SBP, respectively in men with CVD at baseline (both interaction <em>P</em> &lt; .05). Gait speed increases were associated with higher SBP in men without CVD (0.76 [0.21, 1.32]), antihypertensive medication non-users (0.96 [0.30, 1.62]), aged &lt;75 years (0.73 [0.05, 1.41]) and ≥75 years (0.76 [0.06, 1.47]). Similar positive, but modest associations for DBP were observed with grip strength in men with CVD, antihypertensive medication non-users, and aged &lt;75 years, and with gait speed in men without CVD, aged &lt;75 years, and irrespective of antihypertensive medication use.</p></div><div><h3>Conclusion</h3><p>In older men, better physical performance is longitudinally associated with higher BP. Mechanisms and implications of these seemingly paradoxical findings, which appears to be modified by CVD status, antihypertensive medication use, and age, requires further investigation.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100317"},"PeriodicalIF":4.3,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004044/pdfft?md5=f631145091c6477e47bf86b469c82f5d&pid=1-s2.0-S1279770724004044-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}