Brain and Cognition最新文献

Introduction

Methods

Results

Conclusion

Previous research has shown that, in both laboratory and real-world contexts, punishment sensitivity is associated with lower risk-taking propensity. The neural underpinnings of the association between punishment sensitivity and risk-taking, however, remain largely unknown. To address this issue, we implemented resting-state functional connectivity (RSFC) and voxel-based morphometry (VBM) methodologies to investigate the neural basis of their relationship in the current study (N=594). The behavioral results confirmed a negative association between punishment sensitivity and risk-taking propensity, which supports the hypothesis. The VBM results demonstrated a positive correlation between punishment sensitivity and gray matter volume in the right orbitofrontal cortex (ROFC). Furthermore, the results of the RSFC analysis revealed that the functional connectivity between ROFC and the right medial temporal gyrus (RMTG) was positively associated with punishment sensitivity. Notably, mediation analysis demonstrated that punishment sensitivity acted as a complete mediator in the influence of ROFC-RMTG functional connectivity on risk-taking. These findings suggest that ROFC-RMTG functional connectivity may be the neural basis underlying the effect of punishment sensitivity on risk-taking propensity, which provides a new perspective for understanding the relationship between punishment sensitivity and risk-taking propensity.

Background

Cognitive control involves flexibly configuring mental resources and adjusting behavior to achieve goal-directed actions. It is associated with the coordinated activity of brain networks, although it remains unclear how both structural and functional brain networks can predict cognitive control. Connectome-based predictive modeling (CPM) is a powerful tool for predicting cognitive control based on brain networks.

Methods

The study used CPM to predict cognitive control in 102 healthy adults from the UCLA Consortium for Neuropsychiatric Phenomics dataset and further compared structural and functional connectome characteristics that support cognitive control.

Results

Our results showed that both structural (r values 0.263–0.375) and functional (r values 0.336–0.503) connectomes can significantly predict individuals’ cognitive control subcomponents. There is overlap between the functional and structural networks of all three cognitive control subcomponents, particularly in the frontoparietal (FP) and motor (Mot) networks, while each subcomponent also has its own unique weight prediction network. Overall, the functional and structural connectivity that supports different cognitive control subcomponents manifests overlapping and distinct spatial patterns.

Conclusions

The structural and functional connectomes provide complementary information for predicting cognitive control ability. Integrating information from both connectomes offers a more comprehensive understanding of the neural underpinnings of cognitive control.

In overt movement, internal models make predictions about the sensory consequences of a desired movement, generating the appropriate motor commands to achieve that movement. Using available sensory feedback, internal models are updated to allow for movement adaptation and in-turn better performance. Whether internal models are updated during motor imagery, the mental rehearsal of movement, is not well established. To investigate internal modelling during motor imagery, 66 participants were exposed to a leftwards prism shift while performing actual pointing movements (physical practice; PP), imagined pointing movements (motor imagery; MI), or no pointing movements (control). If motor imagery updates internal models, we hypothesized that aftereffects (pointing in the direction opposite the prism shift) would be observed in MI, like that of PP, and unlike that of control. After prism exposure, the magnitude of aftereffects was significant in PP (4.73° ± 1.56°), but not in MI (0.34° ± 0.96°) and control (0.34° ± 1.04°). Accordingly, PP differed significantly from MI and control. Our results show that motor imagery does not update internal models, suggesting that it is not a direct simulation of overt movement. Furthering our understanding of the mechanisms that underlie learning through motor imagery will lead to more effective applications of motor imagery.

Development of attentional skills and inhibitory control rely on maturational changes in the brain across childhood and youth. However, both brain anatomy and different components of attention and inhibition show notable individual variation. Research on ADHD and inhibitory training and control have shown that variations in the thickness and surface area of particularly inferior cortical structures are associated with attentional control. However, the intricacies of how the development of inhibitory control is associated with the anatomical variations beyond the general age- and gender-dependent differences have not been resolved. Here, we sought to address these questions by quantifying the cortical thickness and surface area in frontal cortical regions and inhibitory control using the stop signal task performance in 6–14-year-old children. Our results showed that the thickness of the left medial orbitofrontal cortex and the surface area of the left caudal anterior cingulate were associated with the inhibitory performance, beyond the variance that could be explained by the subjects’ age and gender. The results highlight the importance of factoring in anatomical variations when following attentional development and the importance of evaluating multiple anatomical measures when aiming to link the properties of cortical structures with variations in cognitive performance.

Readers frequently encounter homographs (e.g., bank) whose resolution requires selection-suppression processes: selecting the contextually relevant meaning, while suppressing the irrelevant one. In two experiments, we investigated how these processes are modulated by the phonological status of the homograph (homographs with one vs. two possible pronunciations); and what is the involvement of the left inferior frontal gyrus (LIFG, including Broca’s area) in these processes. To these ends, Experiment 1 utilized the context verification task with two types of Hebrew homographs: homophonic (e.g., bank) and heterophonic (e.g., tear). In the task, participants read sentences ending either with a homograph (e.g., bank) or an unambiguous word (e.g., shore). The sentences were biased towards the homograph’s subordinate meaning (e.g., The fisherman sat on the bank/shore), and were followed by a target word related to the homograph’s dominant meaning (e.g., MONEY). The participants were asked to judge whether the target was related to the overall meaning of the sentence. An ambiguity effect was observed for both types of homographs, reflecting interference from the irrelevant dominant meaning. However, this ambiguity effect was larger for heterophonic than for homophonic homographs, indicating that dominant meanings of heterophonic homographs are more difficult to suppress. Experiment 2 was identical, except that the procedure was coupled with transcranial direct current stimulation (tDCS) over the LIFG (including Broca’s area). We found that stimulating the LIFG abolished the ambiguity effect, but only in the case of heterophonic homographs. Together, these findings highlight the distinction between phonological and semantic levels of selection-suppression processes, and the involvement of the LIFG in the phonological level of these processes.

Topographical disorientation is linked to lesions in the right hemisphere and typically resolves within a few months post-stroke. Persistent topographical disorientation is uncommon and frequently accompanied by impairments in visual memory, complicating the analysis of the underlying mechanisms. Herein, we report two cases of sustained pure topographical disorientation following cerebral hemorrhages in the left retrosplenial region. The patients exhibited disorientation in both familiar and unfamiliar settings, attributable to heading disorientation, a deficit in determining the directional relationship between one’s current position and a target location or external frames. The patients struggled with reconstructing large-scale spatial frameworks and integrating new egocentric and allocentric perspectives upon changes in body orientation. There were no landmark agnosia, egocentric disorientation, or anterograde disorientation. Although mild verbal memory deficits were observed, no other cognitive impairments, including visual memory deficits, were detected. Our findings imply that lesions confined to the left retrosplenial region can induce enduring heading disorientation and suggest a significant role for this area in processing and integrating spatial information necessary for large-scale navigation. Clarifying the features of topographical disorientation will significantly impact the therapeutic approaches, enhancing the quality of life for affected patients by restoring their independence and mobility.