Shivashankar Kengadaran, Anusha Divvi, Joseph John
Background: Dental diseases are a major public health problem worldwide. The World Health Organization reports a prevalence of over 60%–90% of dental caries and gingiva diseases among school children worldwide. Fluoridated dentifrices were considered to be the gold standard for the prevention of dental diseases. However, the side effects encountered with these dentifrices have led to the search for novel and safe alternatives. Aim: This study aims to compare the effectiveness of Ayurvedic, Homeopathic, and Conventional dentifrice on the gingiva. Setting and Design: Double-blinded, parallel-group, randomized clinical trial. Materials and Methods: The study was conducted among healthy adults. Subjects were randomly allocated to three groups (n = 54). Group I-Herbal dentifrice, Group II-Homeopathic dentifrice and Group III-Fluoride dentifrice. Plaque and gingival indices were recorded at baseline, 14th day, and 28th day of follow-up. Statistical Analysis Used: Paired t-test and One-way ANOVA. Results: The mean plaque and gingiva index scores were significantly reduced by all treatment groups at the 28th day follow-up. The mean gingival index scores were reduced among all three groups. However, Group I showed the highest reduction (Group I [0.46 ± 0.09] followed by Group II [0.50 ± 0.10] and Group III [0.50 ± 0.14]) at the 14th day and (Group I [0.45 ± 0.09] followed by Group II [0.49 ± 0.06] and Group III [0.44 ± 0.9]) at the 28th day, respectively. The reduction was found to be statistically significant. Conclusion: All three groups exhibited antiplaque activity by bringing about a significant reduction in mean plaque and gingival index at 14th day and 28th day. Among all the dentifrices, Group I (Herbal dentifrice) showed better results compared to other groups.
{"title":"Comparing the effectiveness of ayurvedic, homeopathic, and conventional dentifrice on gingiva: A double-blind randomized controlled trial","authors":"Shivashankar Kengadaran, Anusha Divvi, Joseph John","doi":"10.4103/jss.jss_265_22","DOIUrl":"https://doi.org/10.4103/jss.jss_265_22","url":null,"abstract":"Background: Dental diseases are a major public health problem worldwide. The World Health Organization reports a prevalence of over 60%–90% of dental caries and gingiva diseases among school children worldwide. Fluoridated dentifrices were considered to be the gold standard for the prevention of dental diseases. However, the side effects encountered with these dentifrices have led to the search for novel and safe alternatives. Aim: This study aims to compare the effectiveness of Ayurvedic, Homeopathic, and Conventional dentifrice on the gingiva. Setting and Design: Double-blinded, parallel-group, randomized clinical trial. Materials and Methods: The study was conducted among healthy adults. Subjects were randomly allocated to three groups (n = 54). Group I-Herbal dentifrice, Group II-Homeopathic dentifrice and Group III-Fluoride dentifrice. Plaque and gingival indices were recorded at baseline, 14th day, and 28th day of follow-up. Statistical Analysis Used: Paired t-test and One-way ANOVA. Results: The mean plaque and gingiva index scores were significantly reduced by all treatment groups at the 28th day follow-up. The mean gingival index scores were reduced among all three groups. However, Group I showed the highest reduction (Group I [0.46 ± 0.09] followed by Group II [0.50 ± 0.10] and Group III [0.50 ± 0.14]) at the 14th day and (Group I [0.45 ± 0.09] followed by Group II [0.49 ± 0.06] and Group III [0.44 ± 0.9]) at the 28th day, respectively. The reduction was found to be statistically significant. Conclusion: All three groups exhibited antiplaque activity by bringing about a significant reduction in mean plaque and gingival index at 14th day and 28th day. Among all the dentifrices, Group I (Herbal dentifrice) showed better results compared to other groups.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"15 1","pages":"383 - 388"},"PeriodicalIF":0.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Partha Chakraborty, P. Halder, Ananya Mandal, Sunil Yadav, Sarannya Ghosh, Anusua Saha
Female infants frequently develop ovarian cysts (OCs), which vary in onset, development, and prognosis. When the placenta tissue secretes excessive human chorionic gonadotrophin for a variety of reasons, the fetus develops an OC. Because estrogen levels fall after childbirth, the majority of OCs may also naturally involute. Hence, treating infants with OCs may involve close observation. However, even in previously asymptomatic OCs, torsion, intracystic bleeding, or ovarian necrosis could manifest suddenly in the neonatal or infantile period. Here, we report nine such cases of OCs and share our experiences with diagnosis and treatment.
{"title":"Complex ovarian cysts in infants: A series of nine cases","authors":"Partha Chakraborty, P. Halder, Ananya Mandal, Sunil Yadav, Sarannya Ghosh, Anusua Saha","doi":"10.4103/jss.jss_247_22","DOIUrl":"https://doi.org/10.4103/jss.jss_247_22","url":null,"abstract":"Female infants frequently develop ovarian cysts (OCs), which vary in onset, development, and prognosis. When the placenta tissue secretes excessive human chorionic gonadotrophin for a variety of reasons, the fetus develops an OC. Because estrogen levels fall after childbirth, the majority of OCs may also naturally involute. Hence, treating infants with OCs may involve close observation. However, even in previously asymptomatic OCs, torsion, intracystic bleeding, or ovarian necrosis could manifest suddenly in the neonatal or infantile period. Here, we report nine such cases of OCs and share our experiences with diagnosis and treatment.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"38 1","pages":"399 - 403"},"PeriodicalIF":0.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Sookaromdee, Rujittika Mungmunpuntipantip, V. Wiwanitkit
{"title":"Mortality rate due to traffic accident and incidence rate of COVID-19: Any relationship?","authors":"P. Sookaromdee, Rujittika Mungmunpuntipantip, V. Wiwanitkit","doi":"10.4103/jss.jss_280_22","DOIUrl":"https://doi.org/10.4103/jss.jss_280_22","url":null,"abstract":"","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"148 1","pages":"422 - 423"},"PeriodicalIF":0.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shankar Gharge, Sushmita I. Hiremath, Akshata Menasinakai, Mahesh Palled
Background: Coronavirus disease 2019 (COVID-19), it is an infectious respiratory disease caused by SARS corona virus 2 (SARS CoV-2). There are several reports of using JAK (Janus kinase)-inhibitors in persons with COVID-19 and the use of these decreased the use of invasive mechanical ventilation and increased survival. There are several ongoing and randomized controlled trials evaluating the therapeutic potential of Janus Kinase inhibitors (JAK i) in severe COVID-19. The structure, metabolic pathways and pathophysiology of COVID-19 associated diseases is important to identify possible drug targets. Hence in 2020, successful crystallized structure of the main protease (Mpro) from COVID-19 has been structured and repositioned in the Protein Data Bank (PDB), which is a potential target for the inhibition of CoV replication. Aims and Objectives: As there are no computational studies have been reported on computer based screening on Janus Kinase inhibitors to investigate its drug likeness properties and ADME profile along with some toxicity investigations. Hence an attempt has been made to study drug likeness properties and ADME profile of selected Janus Kinase inhibitors using computer applications and servers. Materials and Methods: The admetSAR and SwissADME servers are used for describing the molecular properties, which is important for a drug pharmacokinetics in the human body and molecular docking study to predict hypothetical binding affinity of protein is mainly done by PyRx 0.8 and visualizied by Biovia Discovery Studio 2021. Results: We have selected few Janus Kinase inhibitors (JAK i) as ligands such as Baricitinib, Upadacitinib, Oclacitinib, Tofacitinib, Ruxolitinib, Fedratinib, Peficitinib and Filgotinib and binding energy score of all inhibitors found to be -6.8, -6.8, -6.7, -5.7, -6.8, -7.7, -6.7 and -7.8 kcal/mol, respectively. Conclusion: The docking analysis in the present study showed the inhibition potential of several compounds, ranked by affinity Filgotinib > Fedratinib >Ruxolitinib, Upadacitinib, Baricitinib > Oclacitinib, Peficitinib > Tofacitinib which were the most recommended Janus Kinase inhibitor (JAKI) found as potential inhibitors of COVID-19 M pro, which should be explored in future research.
{"title":"In silico method potential therapeutic use of Janus Kinase inhibitors as severe acute respiratory syndrome coronavirus 2 main protease inhibitors","authors":"Shankar Gharge, Sushmita I. Hiremath, Akshata Menasinakai, Mahesh Palled","doi":"10.4103/jss.jss_156_22","DOIUrl":"https://doi.org/10.4103/jss.jss_156_22","url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19), it is an infectious respiratory disease caused by SARS corona virus 2 (SARS CoV-2). There are several reports of using JAK (Janus kinase)-inhibitors in persons with COVID-19 and the use of these decreased the use of invasive mechanical ventilation and increased survival. There are several ongoing and randomized controlled trials evaluating the therapeutic potential of Janus Kinase inhibitors (JAK i) in severe COVID-19. The structure, metabolic pathways and pathophysiology of COVID-19 associated diseases is important to identify possible drug targets. Hence in 2020, successful crystallized structure of the main protease (Mpro) from COVID-19 has been structured and repositioned in the Protein Data Bank (PDB), which is a potential target for the inhibition of CoV replication. Aims and Objectives: As there are no computational studies have been reported on computer based screening on Janus Kinase inhibitors to investigate its drug likeness properties and ADME profile along with some toxicity investigations. Hence an attempt has been made to study drug likeness properties and ADME profile of selected Janus Kinase inhibitors using computer applications and servers. Materials and Methods: The admetSAR and SwissADME servers are used for describing the molecular properties, which is important for a drug pharmacokinetics in the human body and molecular docking study to predict hypothetical binding affinity of protein is mainly done by PyRx 0.8 and visualizied by Biovia Discovery Studio 2021. Results: We have selected few Janus Kinase inhibitors (JAK i) as ligands such as Baricitinib, Upadacitinib, Oclacitinib, Tofacitinib, Ruxolitinib, Fedratinib, Peficitinib and Filgotinib and binding energy score of all inhibitors found to be -6.8, -6.8, -6.7, -5.7, -6.8, -7.7, -6.7 and -7.8 kcal/mol, respectively. Conclusion: The docking analysis in the present study showed the inhibition potential of several compounds, ranked by affinity Filgotinib > Fedratinib >Ruxolitinib, Upadacitinib, Baricitinib > Oclacitinib, Peficitinib > Tofacitinib which were the most recommended Janus Kinase inhibitor (JAKI) found as potential inhibitors of COVID-19 M pro, which should be explored in future research.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"9 1","pages":"356 - 363"},"PeriodicalIF":0.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypospadias is a common congenital anomaly. Treatment for hypospadias is surgical, but there is no technique that is recognized as the gold standard. The most common complication occurring after hypospadias repair is urethrocutaneous fistula with a reported incidence varying from 4% to 28%. The use of an intermediate layer between the neourethra and the skin is one of the most important techniques used to reduce the likelihood of fistula formation. Several coverage techniques have been described including local subcutaneous penile tissue, tunica vaginalis, dartos, and extragenital tissues. In addition to tissue flaps, fibrin sealants have been introduced to prevent fistula formation. Platelet-rich fibrin membrane is an autologous source of growth factors and has been used to prevent fistulous complications.
{"title":"Use of platelet-rich fibrin in hypospadias surgery","authors":"Rajendra Nerli, S. Rangrez, C. Saniya","doi":"10.4103/jss.jss_123_22","DOIUrl":"https://doi.org/10.4103/jss.jss_123_22","url":null,"abstract":"Hypospadias is a common congenital anomaly. Treatment for hypospadias is surgical, but there is no technique that is recognized as the gold standard. The most common complication occurring after hypospadias repair is urethrocutaneous fistula with a reported incidence varying from 4% to 28%. The use of an intermediate layer between the neourethra and the skin is one of the most important techniques used to reduce the likelihood of fistula formation. Several coverage techniques have been described including local subcutaneous penile tissue, tunica vaginalis, dartos, and extragenital tissues. In addition to tissue flaps, fibrin sealants have been introduced to prevent fistula formation. Platelet-rich fibrin membrane is an autologous source of growth factors and has been used to prevent fistulous complications.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"62 1","pages":"287 - 289"},"PeriodicalIF":0.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139343853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is widely recognized that Vitamin B12, also known as cyanocobalamin, is a nutrient that keeps the body's nerves and blood cells healthy and contributes in deoxyribonucleic acid synthesis. Megaloblastic anemia, a form of anemia that causes fatigue and weakness, can be prevented with Vitamin B12. The main objective of this case report was to draw attention to the rare hypersensitive reactions which can occur after injecting Vitamin B12 supplement therapy. The abovementioned reaction could be a result to an immunoglobulin E-mediated reaction or due to sensitization to the Vitamin B12 molecule itself. Here, we have reported the case of a 25-year-old female patient, a known case of pulmonary tuberculosis, who was hospitalized and on medication of fixed dose of directly observed treatment, short-course, nebulizer Combimist, tablet beclomethasone, and cyanocobalamin injection. We deduce that the anaphylactoid reaction to Vitamin B12 is a rare but serious side effect and that it should be vigilantly monitored while administering the drug to the patient, especially if the parenteral route is preferred.
{"title":"Cyanocobalamin-induced anaphylactic reaction","authors":"C. Sajan, Elizabeth Jacob","doi":"10.4103/jss.jss_180_22","DOIUrl":"https://doi.org/10.4103/jss.jss_180_22","url":null,"abstract":"It is widely recognized that Vitamin B12, also known as cyanocobalamin, is a nutrient that keeps the body's nerves and blood cells healthy and contributes in deoxyribonucleic acid synthesis. Megaloblastic anemia, a form of anemia that causes fatigue and weakness, can be prevented with Vitamin B12. The main objective of this case report was to draw attention to the rare hypersensitive reactions which can occur after injecting Vitamin B12 supplement therapy. The abovementioned reaction could be a result to an immunoglobulin E-mediated reaction or due to sensitization to the Vitamin B12 molecule itself. Here, we have reported the case of a 25-year-old female patient, a known case of pulmonary tuberculosis, who was hospitalized and on medication of fixed dose of directly observed treatment, short-course, nebulizer Combimist, tablet beclomethasone, and cyanocobalamin injection. We deduce that the anaphylactoid reaction to Vitamin B12 is a rare but serious side effect and that it should be vigilantly monitored while administering the drug to the patient, especially if the parenteral route is preferred.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"2 1","pages":"407 - 409"},"PeriodicalIF":0.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Sajan, H. Patel, Dullari Patel, Twinkal Patet, Bhumi Vadodariya, H. Rajput
Background: Depression is one of the most common mental disorders. There is evidence that depression is more common among college students. Diminished capacity to do regular chores and decreased quality of life are frequent complaints. The objectives of our study are to assess the depression in gender disparity and to assess the depression in the field of pharmacy on graduate and undergraduate students. Materials and Methods: In India, from the state of Gujarat, 7 institutes participated in the study. The updated Centre for Epidemiologic Studies Depression Scale was implemented in this investigation. The sample size is 370 in total. Results: Among 370 students, 56.49% were male and 43.51% were female. The study has shown that students of pharmacy who lived at their relative's place have experienced severe depression in a greater number (81.36%). Mild depression was commonly found in students who lived at home (35.32%). Students who were new to course, i.e., 1st-year students in a greater number have experienced severe depression (67.19%). A greater number of students from colleges of the east-central area suffered from severe depression (33.78%). Severe depression was found to be common in M. Pharm students among all students (70.83%). Conclusion: The study indicated that male students were more likely than female students to experience more depression. Students who were new to the course and students who were in master degree had a higher risk of severe depression.
{"title":"Prevalence of depression among pharmacy students of Gujarat","authors":"C. Sajan, H. Patel, Dullari Patel, Twinkal Patet, Bhumi Vadodariya, H. Rajput","doi":"10.4103/jss.jss_179_22","DOIUrl":"https://doi.org/10.4103/jss.jss_179_22","url":null,"abstract":"Background: Depression is one of the most common mental disorders. There is evidence that depression is more common among college students. Diminished capacity to do regular chores and decreased quality of life are frequent complaints. The objectives of our study are to assess the depression in gender disparity and to assess the depression in the field of pharmacy on graduate and undergraduate students. Materials and Methods: In India, from the state of Gujarat, 7 institutes participated in the study. The updated Centre for Epidemiologic Studies Depression Scale was implemented in this investigation. The sample size is 370 in total. Results: Among 370 students, 56.49% were male and 43.51% were female. The study has shown that students of pharmacy who lived at their relative's place have experienced severe depression in a greater number (81.36%). Mild depression was commonly found in students who lived at home (35.32%). Students who were new to course, i.e., 1st-year students in a greater number have experienced severe depression (67.19%). A greater number of students from colleges of the east-central area suffered from severe depression (33.78%). Severe depression was found to be common in M. Pharm students among all students (70.83%). Conclusion: The study indicated that male students were more likely than female students to experience more depression. Students who were new to the course and students who were in master degree had a higher risk of severe depression.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"210 - 213"},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45673708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abolfazl Taher, M. Sadrabad, Armin Izadi, R. Ghorbani, Shabnam Sohanian, E. Saberian
Backround: In this study, we aimed to investigate the effect of dentin matrix proteins on the differentiation of guinea pig dental pulp stem cells to regenerate Dentin Bridge. Materials and Methods: This experimental study was performed on six adult male guinea pigs. Pig incisor teeth were divided into two groups: the first group was induced by calcium hydroxide as a control group and the second group was induced by matrix protein induction as a case group. After 1 and 3 days, the samples of both groups were stained by hematoxylin and eosin to examine the presence of odontoblast-like cells, the severity of inflammation, and the type and amount of dentin which was made, microscopically and for counting stem cells in the dentin site. Immunohistochemistry staining method was done. Results: In the case group, the amount of reconstituted dentin, the presence of stem cells and odontoblastic differentiation were higher than in the control group (P < 0.05) and the type of regenerated dentin potentially was of higher quality, although it was not statistically significant (P = 0.924). However, the amount of regenerated dentin (P = 0.001), the presence of pulp stem cells (P = 0.001) and the increased quality of regenerated dentin (P = 0.001) in both groups on the 1st and 3rd days were significantly different. Conclusion: The results showed that dentin matrix proteins were more effective on stem cell migration, odontoblastic differentiation, amount and quality of restorative dentin than the control group, but did not significantly; probably because low sample size.
{"title":"The effect of dentin matrix proteins on differentiation of autologous guinea pig dental pulp stem cells","authors":"Abolfazl Taher, M. Sadrabad, Armin Izadi, R. Ghorbani, Shabnam Sohanian, E. Saberian","doi":"10.4103/jss.jss_186_22","DOIUrl":"https://doi.org/10.4103/jss.jss_186_22","url":null,"abstract":"Backround: In this study, we aimed to investigate the effect of dentin matrix proteins on the differentiation of guinea pig dental pulp stem cells to regenerate Dentin Bridge. Materials and Methods: This experimental study was performed on six adult male guinea pigs. Pig incisor teeth were divided into two groups: the first group was induced by calcium hydroxide as a control group and the second group was induced by matrix protein induction as a case group. After 1 and 3 days, the samples of both groups were stained by hematoxylin and eosin to examine the presence of odontoblast-like cells, the severity of inflammation, and the type and amount of dentin which was made, microscopically and for counting stem cells in the dentin site. Immunohistochemistry staining method was done. Results: In the case group, the amount of reconstituted dentin, the presence of stem cells and odontoblastic differentiation were higher than in the control group (P < 0.05) and the type of regenerated dentin potentially was of higher quality, although it was not statistically significant (P = 0.924). However, the amount of regenerated dentin (P = 0.001), the presence of pulp stem cells (P = 0.001) and the increased quality of regenerated dentin (P = 0.001) in both groups on the 1st and 3rd days were significantly different. Conclusion: The results showed that dentin matrix proteins were more effective on stem cell migration, odontoblastic differentiation, amount and quality of restorative dentin than the control group, but did not significantly; probably because low sample size.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"214 - 219"},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41724986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.5958/2230-7273.2022.00035.7
Prince Kumar, Swarndeep Singh, S. Mishra
Background: The precision fit at the implant-abutment interface is a significant criterion for the success of implant restorations clinically. Various factors are involved in it, including fabrication techniques and utilized materials. The misfit at the implant-abutment interface is capable of causing screw loosening and fracture of the abutment screws. Aim: The aim of the study was to evaluate the marginal fit of premachined and castable abutment at implant-abutment connection interface using stereomicroscope. Materials and Methods: Fifteen castable abutments (Group A) and 15 premachined titanium abutments (Group B) were used for the study and connected to titanium implants and evaluated under the stereomicroscope. Images of the sample were recorded at three equidistant points at the implant-abutment interface to measure the vertical microgap at the platform level. The data were subjected to statistical evaluation using the “t”-test. Results: Data were sent for the statistical analysis by the software Statistical Package for the Social Sciences version. The mean for Group A (customized abutments) at mesiobuccal point was 13.2199 with a standard error of 0.5281. For premachined abutments, it was 6.4629 and with a standard error of 0.3201. Similarly, the mean for Group A (customized abutments) at the distobuccal point was 12.0861 with a standard error of 0.3428. On comparative assessment, the mean microgap in between the groups showed significant difference (Tukey test). Conclusion: On implant-abutment interface at the platform level, the microgaps of premachined implant abutments were significantly lesser than the casted implant abutments. Furthermore, the microgap of both tested groups was found within the clinically acceptable ranges.
背景:种植体-基牙界面的精确配合是临床种植体修复成功的重要标准。它涉及各种因素，包括制造技术和使用的材料。种植体-基牙界面处的不配合会导致基牙螺钉松动和断裂。目的:应用体视显微镜评价预制基牙与铸造基牙在种植体-基牙连接界面的边缘配合度。材料与方法:采用15个铸造基牙(A组)和15个预制钛基牙(B组)，与钛种植体连接，体视显微镜下观察。在种植体-基牙界面的三个等距点记录样品的图像，以测量平台水平的垂直微间隙。数据采用“t”检验进行统计评价。结果:使用statistical Package for Social Sciences version软件发送数据进行统计分析。A组(定制基牙)在中颊点的平均值为13.2199，标准误差为0.5281。预加工基台的标准误差为6.4629，标准误差为0.3201。同样，A组(定制基台)在分布点的平均值为12.0861，标准误差为0.3428。经比较，两组间平均微差差异有统计学意义(Tukey检验)。结论:在种植体-基台交界面上，预制基台的微间隙明显小于铸造基台。此外，两组的微间隙均在临床可接受的范围内。
{"title":"Stereomicroscopic evaluation of marginal fit of premachined and castable abutments at implant abutment connection interface – An In Vitro study","authors":"Prince Kumar, Swarndeep Singh, S. Mishra","doi":"10.5958/2230-7273.2022.00035.7","DOIUrl":"https://doi.org/10.5958/2230-7273.2022.00035.7","url":null,"abstract":"Background: The precision fit at the implant-abutment interface is a significant criterion for the success of implant restorations clinically. Various factors are involved in it, including fabrication techniques and utilized materials. The misfit at the implant-abutment interface is capable of causing screw loosening and fracture of the abutment screws. Aim: The aim of the study was to evaluate the marginal fit of premachined and castable abutment at implant-abutment connection interface using stereomicroscope. Materials and Methods: Fifteen castable abutments (Group A) and 15 premachined titanium abutments (Group B) were used for the study and connected to titanium implants and evaluated under the stereomicroscope. Images of the sample were recorded at three equidistant points at the implant-abutment interface to measure the vertical microgap at the platform level. The data were subjected to statistical evaluation using the “t”-test. Results: Data were sent for the statistical analysis by the software Statistical Package for the Social Sciences version. The mean for Group A (customized abutments) at mesiobuccal point was 13.2199 with a standard error of 0.5281. For premachined abutments, it was 6.4629 and with a standard error of 0.3201. Similarly, the mean for Group A (customized abutments) at the distobuccal point was 12.0861 with a standard error of 0.3428. On comparative assessment, the mean microgap in between the groups showed significant difference (Tukey test). Conclusion: On implant-abutment interface at the platform level, the microgaps of premachined implant abutments were significantly lesser than the casted implant abutments. Furthermore, the microgap of both tested groups was found within the clinically acceptable ranges.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"254 - 258"},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45010755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Platelet-rich plasma (PRP) is a highly enriched combination of growth factors and pro-inflammatory cytokines which has shown success in cartilage healing. Furthermore, the fibrinogen in PRP may be triggered to produce a fibrin matrix to fill articular defects, so satisfying the basic needs of biological wound repair. The proliferative, anti-inflammatory, and scaffolding properties of PRP are discussed in this article obtained from laboratory experiments, observational studies, and clinical testing. PRP has been seen in culture to boost cell growth and calcareous matrix formation by osteocytes and mature mesenchymal stem cells (MSCs), promote matrix release by synoviocytes, reduce interleukin-1-induced inflammatory, and offer a favorable platform for MSCs. PRP has been utilized in preclinical trials as a hydrogel to fill cartilage deficiencies with varying results, or to stop the course of disease in animal models with beneficial results. Existing medical study findings indicate that PRP may have the capacity to fill tissue defects to promote cartilage regeneration, alleviate arthritis symptoms, and boost joint mobility while maintaining a reasonable safety profile. Despite the fact that current data indicates to prefer PRP above hyaluronan for the management of pain, the effectiveness of PRP therapies is undetermined due to the very diverse character of published research and the varying content of PRP formulations. Future research will be needed to identify the functional group actions of specific PRP components in modifying certain disease pathways.
{"title":"A review on the experimental role of platelet-rich plasma as a biological stimulator for cartilage regeneration","authors":"Kuldeep Chhatbar","doi":"10.4103/jss.jss_106_22","DOIUrl":"https://doi.org/10.4103/jss.jss_106_22","url":null,"abstract":"Platelet-rich plasma (PRP) is a highly enriched combination of growth factors and pro-inflammatory cytokines which has shown success in cartilage healing. Furthermore, the fibrinogen in PRP may be triggered to produce a fibrin matrix to fill articular defects, so satisfying the basic needs of biological wound repair. The proliferative, anti-inflammatory, and scaffolding properties of PRP are discussed in this article obtained from laboratory experiments, observational studies, and clinical testing. PRP has been seen in culture to boost cell growth and calcareous matrix formation by osteocytes and mature mesenchymal stem cells (MSCs), promote matrix release by synoviocytes, reduce interleukin-1-induced inflammatory, and offer a favorable platform for MSCs. PRP has been utilized in preclinical trials as a hydrogel to fill cartilage deficiencies with varying results, or to stop the course of disease in animal models with beneficial results. Existing medical study findings indicate that PRP may have the capacity to fill tissue defects to promote cartilage regeneration, alleviate arthritis symptoms, and boost joint mobility while maintaining a reasonable safety profile. Despite the fact that current data indicates to prefer PRP above hyaluronan for the management of pain, the effectiveness of PRP therapies is undetermined due to the very diverse character of published research and the varying content of PRP formulations. Future research will be needed to identify the functional group actions of specific PRP components in modifying certain disease pathways.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"155 - 158"},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46880468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：