Journal of Stomatology Oral and Maxillofacial Surgery最新文献_第10页

Comparative assessment of various implant configurations for atrophic maxilla: A three-dimensional finite element analysis 不同种植体结构对萎缩上颌骨的比较评估：三维有限元分析。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-10-09 DOI: 10.1016/j.jormas.2025.102608

Fatih Girgin, Onur Yilmaz

Objective

This study aimed to evaluate stress distributions in zygomatic, trans-sinus, and pterygoid implants and the surrounding atrophic maxillary alveolar bone using finite element analysis (FEA).

Methods

Three-dimensional (3D) FEA models with 10-mm conventional implants in the lateral incisor regions were designed. For posterior anchorage, 30° trans-sinus or 45° zygomatic implants (placed using the extrasinus technique) were positioned in the second premolar region, with or without 45° pterygoid implants in the second molar region. Accordingly, four models were created: (1) zygomatic, (2) zygomatic and pterygoid, (3) trans-sinus, and (4) trans-sinus and pterygoid implant. A titanium bar-supported polymethyl methacrylate prosthesis was designed for occlusal restoration. A force of 300 N was applied vertically and obliquely (at 20°) to each model.

Results

Oblique forces caused higher stress than vertical forces. Compared with trans-sinus implant models, zygomatic implant models exhibited lower stress under vertical loading (except in the premolar implants and cancellous bone) and oblique loading (except in the cancellous bone around the anterior implant). Adding pterygoid implants to those in the All-on-4 protocol (All-on-6 protocol) significantly reduced stresses on the bone and restoration, and the von Mises stress in the premolar implants decreasing by >50 % in the pterygoid models.

Conclusion

The most ideal configuration for rehabilitation of the atrophic maxilla was Model 2 with zygomatic and pterygoid implants, but the stress values in Model 4, which used trans-sinus and pterygoid implants, were close to those in Model 2. Pterygoid implants can be considered a useful addition to All-on-4 or zygomatic implants.

目的：本研究旨在利用有限元分析（FEA）评估颧、经鼻窦和翼状骨种植体及其周围萎缩的上颌牙槽骨的应力分布。方法：采用10 mm常规种植体设计侧切牙区三维有限元模型。对于后支抗，在第二前磨牙区放置30°经鼻窦或45°颧种植体（使用肌外技术放置），在第二磨牙区放置45°翼状种植体或不放置45°翼状种植体。据此，建立了四种模型：(1)颧骨模型，(2)颧骨-翼状模型，(3)经鼻窦模型，(4)经鼻窦-翼状假体模型。设计了一种钛棒支撑的聚甲基丙烯酸甲酯假体用于咬合修复。每个模型垂直和斜（20°）施加300牛的力。结果：斜向力引起的应力高于垂直力。与经鼻窦种植体模型相比，颧种植体模型在垂直载荷（前磨牙种植体和松质骨除外）和斜向载荷（前种植体周围松质骨除外）下的应力较低。在4 -on- 4方案（6 -on- 6方案）的基础上添加翼状种植体，显著降低了骨和修复的应力，翼状模型中前磨牙种植体的von Mises应力降低了50%。结论：颧骨和翼状种植体的模型2是修复萎缩上颌最理想的构型，而经鼻窦和翼状种植体的模型4的应力值与模型2接近。翼状假体可以被认为是对All-on-4或颧假体的有用补充。

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引用次数: 0

An automated diagnostic support system for jaw pathologies on panoramic radiographs: a DenseNet121-CBAM deep learning study with histopathological correlation 全景x线片颌骨病理的自动诊断支持系统：与组织病理相关性的DenseNet121-CBAM深度学习研究。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-10-09 DOI: 10.1016/j.jormas.2025.102604

Darpit K Brahmbhatt, Jigna S Shah

Objectives

To develop and prospectively validate a novel deep learning model, integrating a DenseNet architecture with a Convolutional Block Attention Module (CBAM), for the automated classification of six common jaw pathologies from orthopantomogram (OPG) images.

Methods

A retrospective dataset of 236 histopathologically confirmed pathological OPGs (Ameloblastoma, Dentigerous Cyst, Odontogenic Keratocyst, Radicular Cyst, Squamous Cell Carcinoma, Osteomyelitis) and 5200 normal OPGs was used for model training and pre-training. The DenseNet121-CBAM model was trained using transfer learning, data augmentation, and a weighted sampler to address class imbalance. Performance was prospectively validated on an independent cohort of 228 cases, with histopathological diagnosis serving as the ground truth.

Results

On the prospective test set, the AI model achieved an overall accuracy of 92.54 % in classifying jaw pathologies against the histopathological gold standard. The model demonstrated robust class-specific performance, with F1-scores ranging from 90 % to 98 %.

Conclusions

The attention-augmented deep learning model provides a rapid and highly accurate method for diagnosing common jaw pathologies on OPGs. Its performance, validated against histopathology, establishes its potential as a reliable diagnostic support tool to enhance clinical workflows and aid in early pathology detection.

目的：开发并前瞻性验证一种新型深度学习模型，将DenseNet架构与卷积块注意模块（CBAM）集成在一起，用于从骨科断层成像（OPG）图像中自动分类六种常见的颌骨病变。方法：回顾性收集236例经组织病理学证实的病理OPGs（成釉细胞瘤、牙髓性囊肿、牙源性角化囊肿、根状囊肿、鳞状细胞癌、骨髓炎）和5200例正常OPGs进行模型训练和预训练。DenseNet121-CBAM模型使用迁移学习、数据增强和加权采样器进行训练，以解决类别不平衡问题。以组织病理学诊断为基础，对228例独立队列进行前瞻性验证。结果：在前瞻性测试集上，人工智能模型根据组织病理学金标准对颌骨病理进行分类的总体准确率为92.54%。该模型显示了稳健的班级特定性能，f1得分范围从90%到98%。结论：注意增强深度学习模型为OPGs常见颌骨病变的诊断提供了一种快速、高精度的方法。其性能经过组织病理学验证，确立了其作为可靠的诊断支持工具的潜力，以增强临床工作流程并帮助早期病理检测。

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引用次数: 0

The use of fluoroscopy-guided sclerotherapy with foam polidocanol for retromolar trigon venous malformation: A case report and review of the literature 透视引导下泡沫聚多醇硬化治疗磨牙后三角静脉畸形1例报告及文献复习。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-10-09 DOI: 10.1016/j.jormas.2025.102610

Razan Baabdullah

Venous malformations (VMs) are vascular anomalies that can pose significant challenges in pediatric patients. This case report describes the successful treatment of a retromolar trigone VM in an eight-year-old child using a single injection of 3 % polidocanol foam using the Tessari technique and administered under fluoroscopic guidance. This resulted in significant reduction of the lesion and complete resolution of symptoms without complications. Follow-up evaluations were scheduled at two weeks, one month, three months, six months, and twelve months post-procedure. At six months post-procedure, there was no detectable lesion, though a minimal residual bluish discoloration persisted on the lingual surface. At twelve months, this discoloration remained unchanged, with no signs of recurrence. This case highlights the efficacy and safety of polidocanol foam sclerotherapy as a minimally invasive treatment option for pediatric maxillofacial VMs. Further studies are warranted to evaluate the long-term outcomes and broader applicability of this technique.

静脉畸形（vm）是一种血管异常，可以对儿科患者构成重大挑战。本病例报告描述了一名8岁儿童的后磨牙三角区VM的成功治疗，使用Tessari技术并在透视指导下单次注射3%聚多醇泡沫。这导致病变显著减少，症状完全解决，无并发症。随访评估安排在术后2周、1个月、3个月、6个月和12个月。术后6个月，未见明显病变，但舌面仍有少量残留的淡蓝色。在12个月时，这种变色保持不变，没有复发的迹象。本病例强调了poly - canol泡沫硬化疗法作为儿童颌面虚拟机的微创治疗选择的有效性和安全性。需要进一步的研究来评估该技术的长期结果和更广泛的适用性。

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引用次数: 0

Erratum to “War as a teacher: Experiences of facial reconstruction with anterolateral thigh flap during the Ukrainian war” [J Stomatol Oral Maxillofac Surg 126 (2025) 102407] “作为老师的战争：在乌克兰战争中使用大腿前外侧皮瓣重建面部的经验”[J]口腔颌面外科杂志126(2025)102407。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.jormas.2026.102720

Bekir Osmanov , Karri Mesimäki , Tetiana Pavlychuk , Tommy Wilkman , Yurii Chepurnyi , Johanna Snäll , Andrii Kopchak

引用次数: 0

Biomechanical study on the stability of mini-implants in the infrazygomatic crest region 颧骨下嵴微型植入物稳定性的生物力学研究。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-02-01 Epub Date: 2025-10-16 DOI: 10.1016/j.jormas.2025.102623

Qian Lin , Yanling Chen , Tingxu Lin , Fuhai Zhao

Objective

To determine insertion angles and force directions that minimize micromotion of infrazygomatic crest (IZC) mini-implants while accounting for the curved lateral wall and the non-parallel bicortical anatomy.

Methods

We built 20 three-dimensional finite element models that preserved full thread geometry and the true IZC bicortical relationship. Two force directions (horizontal vs. vertical), five insertion angles (15°–70°), and single vs. double cortical engagement were tested under a 2 N load. Outcomes included implant displacement and von Mises stress in the screw and surrounding bone.

Results

Vertical loading consistently halved displacement compared with horizontal loading (mean 7.3 ± 2.9 μm vs. 14.7 ± 6.2 μm). Under horizontal forces, 45° minimized displacement (8.1 μm) and cortical stress (92 MPa); under vertical forces, 15° performed best (4.6 μm). Effect sizes were substantial: vertical vs. horizontal displacement ratio ≈ 0.50; 45° vs. 70° cortical stress reduction ≈ 33–40 % under horizontal loading. Penetrating the thin sinus floor (∼0.45 mm) did not improve stability.

Conclusion

For IZC anchorage, 15–45° insertion with predominantly vertical force reduces stress and micromotion; thin bicortical engagement provides no additional benefit. These anatomy-aware rules are readily applicable chairside.

目的：考虑到颧下嵴弯曲的外侧壁和非平行的双皮质解剖结构，确定使颧下嵴微型植入物微动最小化的植入角度和受力方向。方法：建立20个三维有限元模型，保留完整的螺纹几何形状和真正的IZC双皮质关系。在2n载荷下，测试了两种力方向（水平与垂直），五个插入角度（15°-70°），单皮质与双皮质接合。结果包括种植体移位和螺钉及周围骨的von Mises应力。结果：与水平加载相比，垂直加载始终使位移减半（平均7.3±2.9 μm比14.7±6.2 μm）。水平力作用下，45°位移最小（8.1 μm），皮质应力最小（92 MPa）；在垂直力作用下，15°角（4.6 μm）效果最佳。效应量很大：垂直与水平位移比≈0.50；水平加载条件下，45°vs 70°的皮质应力降低≈33-40%。穿透薄窦底（~ 0.45 mm）不能提高稳定性。结论：对于IZC支具，以垂直力为主的15-45°插入可减少应力和微动；薄的双皮质接触不会带来额外的好处。这些与解剖学相关的规则在椅子旁很容易适用。

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引用次数: 0

Automated 3D Craniofacial Cephalometry in Orthognathic Surgery: A Preliminary Evaluation 自动3D颅面测量在正颌手术中的应用：初步评估。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-02-01 Epub Date: 2025-08-24 DOI: 10.1016/j.jormas.2025.102537

Astrid Aisenfarb , Arlette Oueiss , Jacques Treil , Emmanuel Chamorey , Charles Savoldelli

Objective

This study aims to evaluate the efficiency and accuracy of an automated three-dimensional (3D) cephalometric software in diagnosing dento-skeletal dysmorphoses and its concordance with standard clinical diagnosis used in orthognathic surgery.

Methods

A retrospective study was conducted at the Department of Otorhinolaryngology and Maxillofacial Surgery of the University Hospital of Nice. Fourteen patients who underwent bimaxillary surgery were included in this analysis. Standardized cephalometric and clinical diagnoses were compared with automated software-generated diagnoses. The statistical agreement between the two approaches was analyzed to assess the reliability of the software.

Results

The software demonstrated a great agreement with our standardized diagnosis and a high reproducibility rate for skeletal measurements. However, it displayed discrepancies in specific parameters, particularly in soft tissue assessments (lack of measurements) and occlusal characteristics.

Conclusion

Automated 3D cephalometry has significant potential as a diagnostic tool in orthognathic surgery. However, refinements are required to improve its accuracy, particularly in soft tissue assessment and occlusal analyses, before it can be fully integrated into routine clinical practice.

目的：本研究旨在评估一种自动三维头颅测量软件诊断牙骨畸形的效率和准确性，以及其与正颌外科标准临床诊断的一致性。方法：在尼斯大学医院耳鼻咽喉颌面外科进行回顾性研究。本分析包括14例接受双颌手术的患者。将标准化的头颅测量和临床诊断与自动化软件生成的诊断进行比较。分析了两种方法之间的统计一致性，以评估软件的可靠性。结果：该软件与我们的标准化诊断和骨骼测量的高再现率显示了很大的一致性。然而，它显示了具体参数的差异，特别是在软组织评估（缺乏测量）和咬合特征。结论：自动3D头测术在正颌手术中具有重要的诊断潜力。然而，在完全融入常规临床实践之前，需要改进以提高其准确性，特别是在软组织评估和咬合分析方面。

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引用次数: 0

Acknowledging our reviewers 感谢我们的审稿人

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-02-01 Epub Date: 2026-02-02 DOI: 10.1016/S2468-7855(26)00021-2

引用次数: 0

Prevalence and clinicopathological correlation of BRAF V600E mutations in ameloblastoma: A PCR study from a tertiary centre in South India BRAF V600E突变在成釉细胞瘤中的患病率和临床病理相关性：来自印度南部三级中心的PCR研究。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-02-01 Epub Date: 2025-09-25 DOI: 10.1016/j.jormas.2025.102575

Logeswari Jayamani , Kavitha Bottu , Leena Dennis Joseph , Ganthimathy Sekhar

Background

Ameloblastoma is a locally aggressive, benign epithelial odontogenic tumor characterized by unpredictable biological behavior and a high recurrence rate. The recent WHO 5th edition classification (2022) has integrated key molecular advances, prominently featuring MAPK pathway mutations such as BRAF V600E. Understanding the prevalence with its clinicopathological associations with BRAF mutations is crucial for prognostication and targeted therapy planning.

Objectives

To determine the status of BRAF V600E mutation in ameloblastoma cases using quantitative real-time PCR and to correlate mutation status with demographic and clinicopathological parameters over a five-year period from a tertiary care centre.

Methods

A retrospective cross-sectional study was conducted on 40 cases of histologically confirmed ameloblastoma and 5 samples of normal odontogenic epithelium (control), using archived formalin-fixed paraffin-embedded tissue. Genomic DNA was isolated and subjected to qRT-PCR for BRAF V600E mutation analysis. Associations with age, gender, site, recurrence, and histopathological type were evaluated using chi-square, Fisher’s exact, and Student’s t-tests.

Results

BRAF V600E mutations were detected in 28 of 40 ameloblastoma cases (70.0 %) and were absent in all control samples. Solid ameloblastoma demonstrated the highest mutation rate (87.5 %), followed by unicystic ameloblastoma (56.5 %), and adenomatoid ameloblastoma (100 %). No cases of peripheral or metastasizing ameloblastoma were observed.

Conclusion

BRAF V600E mutation is prevalent in ameloblastoma and varies across histopathological subtypes. Although statistical associations with clinicopathological features were limited, the mutation’s high frequency underscores its diagnostic and therapeutic significance in ameloblastoma, justifying routine screening as part of a personalized management approach.

背景：成釉细胞瘤是一种局部侵袭性的良性上皮性牙源性肿瘤，具有不可预测的生物学行为和高复发率。最近的世卫组织第5版分类（2022年）整合了关键的分子进展，突出突出了BRAF V600E等MAPK通路突变。了解患病率及其与BRAF突变的临床病理关联对于预测和靶向治疗计划至关重要。目的：利用实时定量PCR确定成釉细胞瘤病例中BRAF V600E突变的状态，并将突变状态与来自三级保健中心的5年期间的人口统计学和临床病理参数相关联。方法：采用归档的福尔马林固定石蜡包埋组织，对40例组织学证实的成釉细胞瘤和5例正常牙源性上皮（对照）进行回顾性横断面研究。分离基因组DNA，采用qRT-PCR进行BRAF V600E突变分析。使用卡方检验、Fisher精确检验和学生t检验评估与年龄、性别、部位、复发和组织病理类型的关系。结果：40例成釉细胞瘤中有28例（70.0%）检测到BRAF V600E突变，所有对照样本均未检测到BRAF V600E突变。实体性成釉细胞瘤的突变率最高（87.5%），其次是单囊性成釉细胞瘤（56.5%）和腺瘤样成釉细胞瘤（100%）。未发现外周性或转移性成釉细胞瘤。结论：BRAF V600E突变在成釉细胞瘤中普遍存在，并且在不同的组织病理学亚型中存在差异。尽管与临床病理特征的统计关联有限，但该突变的高频率强调了其在成釉细胞瘤中的诊断和治疗意义，证明常规筛查是个性化管理方法的一部分。

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引用次数: 0

The efficacy of thyme honey mouth rinse on polypharmacy-induced xerostomia: A randomized controlled clinical trial with a biochemical assessment 百里香蜂蜜漱口水对多药性口干的疗效：一项随机对照临床试验及生化评估。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-02-01 Epub Date: 2025-11-04 DOI: 10.1016/j.jormas.2025.102641

Suzan S. Ibrahim , Neven Nabil Tadry , Ola M. Ezzatt , Radwa R. Hussein

Background

The global prevalence of systemic diseases and subsequent drug consumption, which is strongly associated with xerostomia, has become increasingly prominent. Considering the significance of maintaining good oral health and hypothesizing that natural salivary stimulants could serve as a safe and effective treatment option, we assessed the therapeutic efficiency of thyme honey mouthwash in treating individuals with polypharmacy-induced xerostomia.

Methods

A randomized controlled trial performed at Ain Shams University's Faculty of Dentistry, Egypt, on 64 patients consuming two or more xerostomia-inducing medications and complaining of dry mouth. Patients were randomly assigned to receive thyme honey oral rinse (Study Group) or normal saline oral rinse (Control Group) (3/day/4weeks). Unstimulated salivary flow rate (USFR), subjective (SDS), and clinical oral dryness scores (CODS) were evaluated at baseline and after 2 and 4 weeks. The salivary nitric oxide levels (SNO) and xerostomia-related quality of life scale (XeQoLS) were assessed at baseline and after 4 weeks.

Results

The USFR showed a notable increase (P < 0.001) in the study group (161.82 ± 89.57 %) compared to the control group (17.11 ± 10.53 %) after 4 weeks, accompanied by an improvement in oral dryness scores. XeQoLS values showed significant improvement, and the SNO levels significantly decreased after using thyme honey mouth rinse for 4 weeks.

Conclusion

The study concluded that the thyme honey mouth rinse effectively increased the salivary secretion, decreased SNO levels and oral dryness scores, and improved the quality of life for patients experiencing polypharmacy-induced xerostomia.

背景：与口干症密切相关的全身性疾病的全球流行和随后的药物消耗已变得越来越突出。考虑到保持良好口腔健康的重要性，并假设天然唾液兴奋剂可以作为一种安全有效的治疗选择，我们评估了百里香蜂蜜漱口水治疗多药性口干症的疗效。方法：在埃及艾因沙姆斯大学牙科学院进行了一项随机对照试验，对64名服用两种或两种以上引起口干的药物并抱怨口干的患者进行了试验。患者随机分为百里香蜂蜜漱口水组（研究组）和生理盐水漱口水组（对照组）（3次/天/4周）。在基线和2周和4周后评估非刺激唾液流率（USFR）、主观（SDS）和临床口腔干燥评分（CODS）。在基线和4周后评估唾液一氧化氮水平（SNO）和口干病相关生活质量量表（XeQoLS）。结果：4周后，研究组USFR（161.82±89.57%）较对照组（17.11±10.53%）显著升高（P < 0.001），同时口腔干燥评分也有所改善。使用百里香蜂蜜漱口水4周后，XeQoLS值显著改善，SNO水平显著降低。结论：百里香蜂蜜漱口水可有效提高多药性口干症患者的唾液分泌，降低SNO水平和口腔干燥评分，改善患者的生活质量。

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引用次数: 0

Immunohistochemical evaluation of Yes-associated protein1 (YAP1) expression in oral leukoplakia and squamous cell carcinoma: Implications for prognosis YAP1在口腔白斑和鳞状细胞癌中表达的免疫组化评价：对预后的影响

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-02-01 Epub Date: 2025-09-12 DOI: 10.1016/j.jormas.2025.102547

Indumathi Nandhakumar , Nandhini Gunasekaran , Rajkumar K , Poonguzhalnalli K

Background

Oral Squamous Cell Carcinoma (OSCC), often preceded by epithelial dysplasia, is a prevalent head and neck malignancy. Yes-associated protein1 (YAP1), a key effector of the Hippo pathway, functions as an oncogene promoting cell proliferation and tumorigenesis. Elevated YAP1 expression has been linked to poor prognosis in OSCC. This study investigates the immunohistochemical expression of YAP1 in normal oral mucosa, epithelial dysplasia, and OSCC to clarify its role in oral carcinogenesis.

Aims and objectives

The present study aims to evaluate the immuno-expression of YAP1 in normal oral mucosa, epithelial dysplasia, and OSCC, with the objective of elucidating its role in tumor progression by correlating expression patterns across these groups.

Methodology

Tissue samples from normal oral mucosa (n = 9), epithelial dysplasia (n = 9), and OSCC (n = 9) were analyzed for YAP1 expression using chromogenic immunohistochemistry. Staining intensity and localization were compared across groups, and statistical significance was assessed via Chi-square test.

Results

YAP1 expression significantly increased from normal mucosa to dysplasia and OSCC (p = 0.001). Normal tissues predominantly showed absent or weak cytoplasmic staining, whereas dysplastic lesions exhibited mixed weak cytoplasmic and focal nuclear staining. OSCC samples demonstrated strong cytoplasmic staining in over 50 % of cells, with notable nuclear localization. This progressive increase in YAP1 expression and altered subcellular distribution correlates with lesion severity, suggesting dysregulated YAP1 activity during malignant transformation.

Conclusion

The findings support YAP1 as a potential biomarker for the malignant progression of Oral Epithelial Dysplasia to OSCC. Enhanced YAP1 expression and nuclear localization may reflect its oncogenic role in oral carcinogenesis. Further studies with larger cohorts and mechanistic analyses are warranted to validate YAP1’s prognostic utility and explore its potential as a therapeutic target in OSCC.

背景：口腔鳞状细胞癌（OSCC）是一种常见的头颈部恶性肿瘤，常伴有上皮发育不良。Yes-associated protein1 （YAP1）是Hippo通路的关键效应因子，是一种促进细胞增殖和肿瘤发生的致癌基因。在OSCC中，YAP1表达升高与预后不良有关。本研究通过对YAP1在正常口腔黏膜、上皮异常增生和OSCC中的免疫组化表达进行研究，以阐明其在口腔癌变中的作用。目的和目的：本研究旨在评估YAP1在正常口腔黏膜、上皮异常增生和OSCC中的免疫表达，目的是通过在这些组中相互关联的表达模式来阐明其在肿瘤进展中的作用。方法：采用显色免疫组织化学方法分析正常口腔黏膜（n=9）、上皮异常增生（n=9）和OSCC （n=9）的组织样本中YAP1的表达。各组间染色强度及定位比较，卡方检验比较差异有统计学意义。结果：YAP1在正常黏膜、异常增生及OSCC中表达显著升高（p=0.001）。正常组织主要表现为细胞质染色缺失或弱染色，而发育不良病变表现为细胞质和局灶性核混合弱染色。OSCC样品显示超过50%的细胞有强烈的细胞质染色，有明显的核定位。YAP1表达的逐渐增加和亚细胞分布的改变与病变严重程度相关，表明在恶性转化过程中YAP1活性失调。结论：这些发现支持YAP1作为口腔上皮异常增生向OSCC恶性进展的潜在生物标志物。YAP1表达增强和核定位可能反映了其在口腔癌变中的致癌作用。进一步的研究需要更大的队列和机制分析来验证YAP1的预后效用，并探索其作为OSCC治疗靶点的潜力。

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引用次数: 0