Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Programmed death-ligand 1 (PDL-1) expression in the oral mucosa of smokeless tobacco users from a low and middle-income country","authors":"Shella S ,&nbsp;Najma Baseer ,&nbsp;Muhammad Shahzad ,&nbsp;Sana Safi","doi":"10.1016/j.jormas.2025.102665","DOIUrl":"10.1016/j.jormas.2025.102665","url":null,"abstract":"<div><h3>Background</h3><div>Smokeless tobacco use is one of the most common causes of oral cancer globally. Naswar, a type of locally manufactured smokeless tobacco product in Pakistan is also associated with high risk of oral cancer but the underlying mechanism of carcinogenicity is not known. Programmed Death-Ligand 1 (PDL-1) is a crucial protein in immune response regulation, particularly in cancer, and its role in Naswar users' oral mucosa remains poorly understood.</div></div><div><h3>Objective</h3><div>To investigate PDL-1 expression in the oral mucosa of Naswar users, elucidating its potential implications for oral health and cancer development.</div></div><div><h3>Methodology</h3><div>This lab-based comparative observational study involves male Naswar users and non-users (<em>n</em> = 50 each group) from Peshawar, Pakistan. Following a written informed consent, data on demographics, Naswar usage and oral health and hygiene practices were collected using standardized questionnaires. Clinical examinations, cytological smears, and saliva samples were obtained for analysis. Immunohistochemistry techniques were employed to assess PDL-1 expression in oral mucosa cells, and for statistical analyses SPSS-v27 was used to analyze the association between the Naswar usage and PDL-1 expression profile.</div></div><div><h3>Results</h3><div>Naswar users exhibited lower adherence to oral hygiene practices compared to non-users. Immunohistochemical analysis revealed varying levels of PDL-1 expression among Naswar users, with 86 % showing no expression, 10 % demonstrating weak expression, and 4 % exhibiting moderate expression, with a significant difference of <em>p</em> = 0.023, in contrast to non-users. Additionally, no significant association was found between oral hygiene status and PDL-1 expression among naswar users.</div></div><div><h3>Conclusion</h3><div>Naswar users exhibited higher levels of PD-L1, potentially suggesting a heightened immunomodulatory response or adaptive mechanism the immune system employs to dampen immune responses and maintain tissue homeostasis in the face of chronic irritation and potential cellular damage caused by toxic Naswar constituents.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102665"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameloblastoma in Chongqing children and adolescents: a review of 16 cases","authors":"Ying Xu,&nbsp;Xiao-Juan Fu,&nbsp;Li Xiang,&nbsp;Wan-Shan Li","doi":"10.1016/j.jormas.2025.102687","DOIUrl":"10.1016/j.jormas.2025.102687","url":null,"abstract":"<div><h3>Background</h3><div>Ameloblastoma is a benign tumor of odontogenic epithelial origin, characterized by local aggression and a high recurrence rate in adults. Although rare in children, it accounts for 10 to 15 % of all ameloblastoma cases. However, a consensus on the clinicopathological features and treatment protocols for this condition remains lacking.</div></div><div><h3>Purpose</h3><div>This study aims to summarize the clinicopathological characteristics of ameloblastoma in pediatric patients within the oral and maxillofacial regions.</div></div><div><h3>Methods</h3><div>Clinical, radiological, and histological data from sixteen pediatric patients who underwent surgical curettage followed by pathological diagnosis of ameloblastoma were retrospectively analyzed.</div></div><div><h3>Results</h3><div>The cohort comprised 11 males and 5 females, yielding a male-to-female ratio of 2.1:1. Patient age at diagnosis ranged from 2 to 13 years (mean age: 7.6 years). Lesions were located in the maxilla in two cases and the mandible in fourteen. Within the mandible, lesions were predominantly found in the posterior teeth region (7 cases, 50.0 %), followed by the mandibular angle (3 cases, 21.43 %), the angle and ramus (1 case, 7.14 %), the ramus (1 case, 7.14 %), the midline of the mandible (1 case, 7.14 %), and the anterior mandible (1 case, 7.14 %). Painless swelling was the most common symptom, observed in 9 of 16 patients (56.25 %). All patients were treated surgically. Radiological findings revealed unilocular lesions in 14 cases, while 2 cases exhibited multilocular lesions. Histologically, 14 cases presented with the solid type, and 2 cases with the unicystic type. Postoperative follow-up ranged from 1 to 81 months, with one recurrence.</div></div><div><h3>Conclusions</h3><div>The recurrence rate of ameloblastoma in children is relatively low. Unicystic ameloblastoma is more prevalent in this population. Simple surgical curettage typically results in a favorable prognosis with minimal recurrence. Early and accurate recognition of the disease’s clinical, radiological, and histological features is critical in reducing misdiagnosis.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102687"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Success rate of dental implants in HIV patients: an overview of systematic reviews","authors":"Ana Waleska Pessôa Barros de AGUIAR ,&nbsp;Pedro Henrique da Hora SALES ,&nbsp;Marco MELETI ,&nbsp;Alessandra Albuquerque Tavares CARVALHO ,&nbsp;Paolo VESCOV ,&nbsp;Jair Carneiro LEÃO","doi":"10.1016/j.jormas.2025.102685","DOIUrl":"10.1016/j.jormas.2025.102685","url":null,"abstract":"<div><div>Aims: To identify whether individuals with positive serology for HIV have a higher risk of losing the dental implant for this treatment. Methods and results: This study was conducted according to PRISMA guidelines and registered in the international prospective registry of systematic reviews, PROSPERO. The databases consulted were MEDLINE via PubMed, Scopus, DARE Cochrane, LILACS, Base, and Google Scholar. The search descriptors: “HIV,” “dental implants” and “AIDS” were used. To assess methodological quality, the AMSTAR 2 tool was used, and the entire process was reviewed in pairs, in addition, a third evaluator was consulted in case of disagreement. Four systematic reviews were included, encompassing 1239 implants in 450 patients with positive serology for HIV. Success rate of the dental implants was 94.72%, with a standard deviation of 0.455%. Three were classified as critically low-quality and one as moderate-quality. Conclusion: Similar implant survival rates were observed in HIV-negative patients. Therefore, the disease itself does not appear to have a significant influence on osseointegration. New controlled studies with low bias and high methodological quality are needed to ensure rehabilitation with dental implants with greater predictability and safety for HIV individuals.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102685"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of fracture fragment displacement on sensory function recovery of the inferior alveolar nerve in mandibular angle fractures","authors":"Zhihui Huang","doi":"10.1016/j.jormas.2025.102684","DOIUrl":"10.1016/j.jormas.2025.102684","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the correlation between the initial, three-dimensionally quantified displacement of mandibular angle fractures and the prognosis of inferior alveolar nerve (IAN) sensory function recovery following open reduction and internal fixation (ORIF).</div></div><div><h3>Methods</h3><div>This retrospective cohort study included patients with unilateral mandibular angle fractures treated with ORIF between March 2022 and August 2025. Preoperative cone-beam computed tomography (CBCT) was used to measure the maximum 3-dimensional (3D) displacement of the fracture fragments. Patients were stratified into three groups based on displacement: mild (&lt;2 mm), moderate (2–5 mm), and severe (&gt;5 mm). IAN sensory function was systematically evaluated through objective tests (light touch, two-point discrimination, and pinprick) and subjective tests (Visual Analog Scale) at preoperative, 1 week, 1 month, 3 months, 6 months, and 12 months follow-ups. Multivariate logistic regression was used to identify independent predictors for complete sensory recovery.</div></div><div><h3>Results</h3><div>A total of 128 patients were included: 45 in the mild, 52 in the moderate, and 31 in the severe displacement groups. The incidence of preoperative IAN sensory deficit was significantly higher in the severe group (67.7%) compared to the moderate (34.6%) and mild (11.1%) groups (<em>p</em> &lt; 0.001). At the 12-month follow-up, the complete recovery rates were 91.1%, 63.5%, and 22.6% for the mild, moderate, and severe groups, respectively (<em>P</em> &lt; 0.001). Multivariable logistic regression identified severe displacement (OR = 0.09, 95% CI: 0.03–0.29), moderate displacement (OR = 0.28, 95% CI: 0.11–0.71), and age&gt;40 years (OR = 0.41, 95% CI: 0.18–0.93) as independent negative predictors for complete sensory recovery.</div></div><div><h3>Conclusion</h3><div>The initial 3D displacement of mandibular angle fractures is a significant predictor of IAN injury severity and postoperative sensory recovery. Preoperative quantitative assessment using CBCT may aid in personalized prognosis, patient counseling, and surgical planning.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102684"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparity in operation decision in Maxillofacial surgery: Influence of gender and social status","authors":"Laure Franchomme,&nbsp;Aurore Loretti,&nbsp;Romain Nicot","doi":"10.1016/j.jormas.2025.102672","DOIUrl":"10.1016/j.jormas.2025.102672","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102672"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of heterodimeric G protein G12 family on proliferation, migration, and invasion in human oral squamous cell carcinoma cells","authors":"Tao-li Fang,&nbsp;Xiao-xia Ma,&nbsp;Sen Yang,&nbsp;Xue-hua Ma,&nbsp;Jiang Xu","doi":"10.1016/j.jormas.2025.102679","DOIUrl":"10.1016/j.jormas.2025.102679","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize the expression of G12 subfamily members (GNA13 and GNA12) in oral squamous cell carcinoma (OSCC) and to evaluate their functional roles in regulating OSCC cell proliferation, migration and invasion.</div></div><div><h3>Methods</h3><div>Public bioinformatic resources were interrogated to profile GNA12 and GNA13 expression and associated functional pathways. Immunohistochemistry was performed on 102 OSCC and 48 adjacent non‑neoplastic tissue specimens, with correlation analyses against clinicopathological parameters and patient survival. Protein and transcript levels were validated in OSCC cell lines by Western blotting and RT‑qPCR. Loss‑of‑function studies using siRNA were followed by CCK‑8, colony formation, Transwell migration/invasion and wound‑healing assays to assess cellular phenotypes.</div></div><div><h3>Results</h3><div>Bioinformatic analyses showed significant upregulation of GNA13 and GNA12 in OSCC (<em>P</em> &lt; 0.001) and enrichment of Rho-mediated signalling pathways. Immunohistochemistry confirmed increased GNA13 and GNA12 expression in tumour tissues compared with adjacent mucosa (<em>P</em> &lt; 0.05). GNA13 expression correlated with tumour differentiation (<em>P</em> = 0.013) and nodal metastasis (<em>P</em> = 0.033), whereas GNA12 expression correlated with tumour differentiation (<em>P</em> = 0.010) and clinical stage (<em>P</em> = 0.027). Overexpression of both genes was associated with poorer overall survival (<em>P</em> &lt; 0.001). Elevated expression in OSCC cell lines was validated by Western blot and RT-qPCR. Functional assays demonstrated that siRNA-mediated knockdown of GNA13 or GNA12 significantly reduced cell viability, colony formation, migration and invasion compared with controls (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Elevated expressions of GNA13 and GNA12 in OSCC tumor tissues and cells are associated with poor patient prognosis. Targeted knockout of GNA13 and GNA12 effectively suppresses malignant behaviors of OSCC, including cell proliferation, migration abilities, and invasive potential. The G12 subfamily may represent a novel therapeutic target for OSCC treatment.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102679"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening tools and strategies for early detection of oral cancer and potentially malignant disorders in rural and low-resource populations: A systematic review","authors":"Amrinderbir Singh ,&nbsp;Gabriela Beraldo Dalben ,&nbsp;Nizar Adio ,&nbsp;Matheus de Castro Costa ,&nbsp;Marina Lara de Carli ,&nbsp;Marcella Ogenchuk ,&nbsp;Felipe Fornias Sperandio","doi":"10.1016/j.jormas.2025.102667","DOIUrl":"10.1016/j.jormas.2025.102667","url":null,"abstract":"<div><div>Oral cancer and its precursor lesions, known as oral potentially malignant disorders (OPMDs), present significant public health challenges due to high morbidity and mortality rates. These issues are particularly pronounced in rural and remote populations, where access to specialized care and early diagnostic services is limited. Socioeconomic disparities, healthcare provider shortages, and geographic isolation contribute to delayed diagnoses and poorer outcomes in these settings. This systematic review evaluated 40 studies focused on early detection strategies for OPMDs and oral squamous cell carcinoma (OSCC) in underserved populations, particularly in rural and low-resource environments. Across 136,257 participants, the review identified diverse screening tools including oral visual examinations, toluidine blue staining, autofluorescence, chemiluminescence, mobile health (mHealth) applications, and artificial intelligence (AI)-based image analysis. The use of low-cost, portable, and technology-driven tools, especially those enabling remote diagnosis and task-sharing with frontline health workers, showed promise in increasing diagnostic accuracy and screening reach. However, variability in performance, training needs, and follow-up adherence remain key limitations. The review also highlighted widespread use of community-based strategies and the value of interdisciplinary collaboration, particularly where dental specialists are not readily available. Innovative, context-sensitive screening tools supported by interdisciplinary networks hold strong potential to enhance early detection of OPMDs and OSCC in rural and underserved communities. Mobile technologies and AI applications are emerging as practical adjuncts to traditional screening methods. To optimize impact, future efforts should prioritize validation of these tools against histopathological standards and the integration of trained non-specialist health workers in community-based screening programs.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102667"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and application of Tai Chi modification of the contralateral submental flap","authors":"Lin Wang ,&nbsp;Dongpo Li ,&nbsp;Fengzhi Liu ,&nbsp;Haijun Zhao ,&nbsp;Xiurong Chen ,&nbsp;Shuangyi Wang","doi":"10.1016/j.jormas.2025.102690","DOIUrl":"10.1016/j.jormas.2025.102690","url":null,"abstract":"<div><h3>Background</h3><div>Tai Chi flap began as a novel design for a radial forearm flap. There have been no reports of submental island Tai Chi flap. This study aims to investigate the feasibility of the Tai Chi modification of the submental flap in the repair of tongue cancer-related defects.</div></div><div><h3>Methods</h3><div>This project was designed as a retrospective cohort study. Clinical data of patients who underwent contralateral Tai Chi modification of the submental flap repair after tongue cancer resection at our institution from April 2024 to April 2025 were retrospectively analyzed.</div></div><div><h3>Results</h3><div>The cohort consisted of 4 patients (3 males and 1 female). No significant postoperative flap necrosis was seen, with only 1 case of tip bruising. In terms of tension in the donor area, the patients self-reported no significant tension in the neck, and no incision cracking was seen after suture removal on the 7th postoperative day. The patient's tongue function recovered well after surgery.</div></div><div><h3>Conclusions</h3><div>The submental island Tai Chi modification of the submental flap reconstructs tongue cancer defects with good postoperative functional recovery. And with low neck tension, the neck suture can be removed earlier.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102690"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative prognostic modeling and mediation analysis of recurrence risk in extremely early-stage oral squamous cell carcinoma","authors":"Yi-quan Chen ,&nbsp;Hai-jun Wu","doi":"10.1016/j.jormas.2025.102708","DOIUrl":"10.1016/j.jormas.2025.102708","url":null,"abstract":"<div><h3>Background</h3><div>Despite complete surgical resection, recurrence remains a substantial challenge in patients with early-stage oral squamous cell carcinoma (OSSC). Conventional TNM staging does not fully capture the biological heterogeneity underlying relapse. This study aimed to develop an individualized recurrence-prediction model integrating clinicopathologic, immune, and spatial factors, and to evaluate the potential mediating role of perineural invasion (PNI).</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 451 patients with stage I–II OSCC treated at Xiangya Hospital between 2018 and 2025. Twenty-three clinical, pathological, and immunohistochemical variables were initially screened using LASSO regression. Independent predictors of recurrence were subsequently identified through multivariable Cox analysis. A nomogram was constructed based on the final Cox model and internally validated using Harrell’s C-index, time-dependent AUCs, and 1,000-bootstrap calibration. Risk stratification was performed using Kaplan–Meier curves, and mediation analysis was used to determine whether PNI mediated the effects of tumor grade, P53 status, and age on recurrence.</div></div><div><h3>Results</h3><div>Six independent predictors were incorporated into the final model: tumor grade, PNI, postoperative lymphocyte nadir, tumor-to-midline distance, pathological stage, and P53 status. The model demonstrated good discrimination (C-index = 0.79) and strong time-dependent predictive accuracy (AUCs: 0.819, 0.825, and 0.807 at 1, 3, and 5 years, respectively). Calibration curves showed excellent agreement between predicted and observed recurrence probabilities. Risk stratification based on the nomogram clearly separated patients into low- and high-risk groups (log-rank p &lt; 0.001). Mediation analysis showed that PNI partially mediated the effects of tumor grade (proportion mediated = 29.6%) and P53 status (7.7%) on recurrence, whereas age exhibited no significant mediation through PNI.</div></div><div><h3>Conclusions</h3><div>This integrated prognostic model combines immune recovery, spatial invasion, and molecular features to accurately predict recurrence in early-stage OSCC. The partial mediation of tumor aggressiveness through PNI highlights a biological pathway linking tumor phenotype to recurrence risk. The proposed nomogram provides a clinically applicable tool for postoperative risk stratification and may assist in tailoring surveillance strategies and individualized adjuvant treatment decisions.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102708"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Squamous cell carcinoma in the lacrimal sac presenting as proptosis: a case report","authors":"Milan Martinez Sanchez ,&nbsp;Annelies Kerckhofs ,&nbsp;Elke Van de Casteele ,&nbsp;Lukas Vaes ,&nbsp;Wouter De Vos","doi":"10.1016/j.jormas.2026.102711","DOIUrl":"10.1016/j.jormas.2026.102711","url":null,"abstract":"<div><h3>Key Clinical Message</h3><div>Lacrimal sac squamous cell carcinoma is extremely rare, and treatment guidelines remain unclear. In select cases, wide en bloc resection combined with prosthetic rehabilitation may offer the best outcomes. This case report advocates a multidisciplinary, consensus-driven approach centered on patient outcomes, with the use of a 3D printed skull with the benefits of gaining insight and providing visualisation pre-operatively. In addition, we want to emphasise the importance of speed in diagnosis and treatment in this report, in order to ensure optimal care.</div></div><div><h3>Summary</h3><div>Lacrimal sac squamous cell carcinoma is a rare epithelial malignancy often misdiagnosed as chronic dacryocystitis, delaying treatment. This article reports a pT4bN2bM0 case in a 67-year-old man treated with wide en bloc resection, yielding clear margins (&gt;6 mm) and found after 4 months from initial symptoms. A 3D-printed skull model aided preoperative visualization. Histology revealed lymphovascular invasion and broad nests of atypical squamous cells with dyskeratosis and necrosis, confirming lacrimal origin. Adjuvant chemoradiotherapy followed. At 21 months follow-up, no signs of local, regional, or distant recurrence were observed.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102711"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}