Pub Date : 2024-10-01DOI: 10.1016/j.jormas.2024.101979
Yunus Balel , Atakan Zogo , Serkan Yıldız , Hakkı Tanyeri
Objective
This study aims to evaluate the capacity of ChatGPT-4o to generate new systematic review ideas in the field of oral and maxillofacial surgery. The data obtained from this study will provide evidence-based information to oral and maxillofacial surgeons regarding the academic use of GPT-4o.
Materials and methods
ChatGPT-4o was asked to provide four previously unpublished systematic review ideas each for the topics of impacted third molars, dental implants, orthognathic surgery, and temporomandibular disorders. A literature search was conducted in the PubMed database to check if the ideas generated by GPT-4o had been previously published, and the search results were compared with the ideas generated by the AI.
Results
The PubMed database search resulted in a total of 871 publications, with 37 publications found to be related to the topics generated by GPT-4o after the first and second screening. Out of the 16 publication ideas generated by GPT-4o, 9 (56.25 %) were determined to be previously unexplored according to the PubMed database search. There was no statistically significant relationship between the presence of ChatGPT's suggestions in PubMed and the subject areas of the studies.
Conclusion
ChatGPT-4o has a high potential to be used as a valuable tool for suggesting systematic review topics in oral and maxillofacial surgery. Additionally, this tool can assist researchers not only in proposing publication ideas but also in developing the methodology of the study.
{"title":"Can ChatGPT-4o provide new systematic review ideas to oral and maxillofacial surgeons?","authors":"Yunus Balel , Atakan Zogo , Serkan Yıldız , Hakkı Tanyeri","doi":"10.1016/j.jormas.2024.101979","DOIUrl":"10.1016/j.jormas.2024.101979","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to evaluate the capacity of ChatGPT-4o to generate new systematic review ideas in the field of oral and maxillofacial surgery. The data obtained from this study will provide evidence-based information to oral and maxillofacial surgeons regarding the academic use of GPT-4o.</div></div><div><h3>Materials and methods</h3><div>ChatGPT-4o was asked to provide four previously unpublished systematic review ideas each for the topics of impacted third molars, dental implants, orthognathic surgery, and temporomandibular disorders. A literature search was conducted in the PubMed database to check if the ideas generated by GPT-4o had been previously published, and the search results were compared with the ideas generated by the AI.</div></div><div><h3>Results</h3><div>The PubMed database search resulted in a total of 871 publications, with 37 publications found to be related to the topics generated by GPT-4o after the first and second screening. Out of the 16 publication ideas generated by GPT-4o, 9 (56.25 %) were determined to be previously unexplored according to the PubMed database search. There was no statistically significant relationship between the presence of ChatGPT's suggestions in PubMed and the subject areas of the studies.</div></div><div><h3>Conclusion</h3><div>ChatGPT-4o has a high potential to be used as a valuable tool for suggesting systematic review topics in oral and maxillofacial surgery. Additionally, this tool can assist researchers not only in proposing publication ideas but also in developing the methodology of the study.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101979"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-12DOI: 10.1016/j.jormas.2024.102071
Emre Balaban,Emine Demir,Özlem Çelebi Erdivanlı,Tolga Mercantepe,Fatih Mehmet Gökçe,Levent Tümkaya,Engin Dursun
AIMTo evaluate the effect of concentrated growth factor (CGF) on regeneration of facial nerve after crush injury.MATERIALS AND METHODSFourteen rats were randomized into two groups. The control group (CG) (n = 7) received a crush injury to the right facial nerve. The CGF group (CGFG) (n = 7) received a crush injury to the right facial nerve and concentrated growth factor prepared from their own blood thereafter. Left facial nerves were used for functional comparison. Nerve function was evaluated using whisker movements and electromyography. Histologic properties were evaluated using hematoxylin and eosin and Masson-trichrome staining, and immunohistochemical properties were evaluated using Neurofilament-H and Anti-Tau degeneration markers.RESULTSIn the CGFG, whisker functions began to recover earlier and recovered more quickly compared with the CG. The CG showed significantly prolonged latency and reduced amplitudes in the first week compared with the CGFG (p < 0.05). Recordings of 4th-week latency and amplitudes were similar to the preoperative period in the CGFG (p > 0.05), whereas recordings of the same week were significantly worse in the CG (p < 0.05). Edema and fibrosis were also more pronounced in the CG compared with the CGFG. Neurofilament-H and Anti-Tau were at significantly high levels in the CG (p < 0.05).CONCLUSIONConcentrated growth factor promotes recovery in facial crush injury and may prove a cost-effective, practical, and effective treatment choice in peripheral nerve injury.
{"title":"The effectiveness of concentrated growth factor in facial nerve crush injury.","authors":"Emre Balaban,Emine Demir,Özlem Çelebi Erdivanlı,Tolga Mercantepe,Fatih Mehmet Gökçe,Levent Tümkaya,Engin Dursun","doi":"10.1016/j.jormas.2024.102071","DOIUrl":"https://doi.org/10.1016/j.jormas.2024.102071","url":null,"abstract":"AIMTo evaluate the effect of concentrated growth factor (CGF) on regeneration of facial nerve after crush injury.MATERIALS AND METHODSFourteen rats were randomized into two groups. The control group (CG) (n = 7) received a crush injury to the right facial nerve. The CGF group (CGFG) (n = 7) received a crush injury to the right facial nerve and concentrated growth factor prepared from their own blood thereafter. Left facial nerves were used for functional comparison. Nerve function was evaluated using whisker movements and electromyography. Histologic properties were evaluated using hematoxylin and eosin and Masson-trichrome staining, and immunohistochemical properties were evaluated using Neurofilament-H and Anti-Tau degeneration markers.RESULTSIn the CGFG, whisker functions began to recover earlier and recovered more quickly compared with the CG. The CG showed significantly prolonged latency and reduced amplitudes in the first week compared with the CGFG (p < 0.05). Recordings of 4th-week latency and amplitudes were similar to the preoperative period in the CGFG (p > 0.05), whereas recordings of the same week were significantly worse in the CG (p < 0.05). Edema and fibrosis were also more pronounced in the CG compared with the CGFG. Neurofilament-H and Anti-Tau were at significantly high levels in the CG (p < 0.05).CONCLUSIONConcentrated growth factor promotes recovery in facial crush injury and may prove a cost-effective, practical, and effective treatment choice in peripheral nerve injury.","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"51 1","pages":"102071"},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-12DOI: 10.1016/j.jormas.2024.102074
Anitha Krishnan Pandarathodiyil, Hema Shree Kasirajan, Suresh Vemuri, G.V. Naga Sai Sujai, Sivapathasundharam B, Ramya Ramadoss
Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disorder. Blood biomarkers, like rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs), lack the sensitivity and specificity for early diagnosis, delaying treatment. This review while highlighting the need for new diagnostic tools, emphasizes the promising avenue of saliva for developing RA biomarkers. This systematic review and meta-analysis assess the effectiveness of salivary biomarkers in the diagnosis and prognosis of RA, examining current evidence and proposing avenues for future research. A literature review following PRISMA 2021 guidelines was conducted using PubMed, Scopus, Web of Science, and Google Scholar to identify studies from the past five years on salivary biomarkers in RA patients compared to healthy controls. The review focused on original research articles, and meta-analysis was performed on studies reporting standard deviation values for inflammatory markers such as IL-6, IL-8, MMP-8, and TNF-alpha. The meta-analysis included eleven studies with 394 RA patients and 255 healthy controls, evaluating IL-8, IL-6, MMP-8, and TNF-α as RA biomarkers. IL-8 showed a mean difference of 7.32 (CI: -5.48 to 20.13), not statistically significant, favouring controls. IL-6 had a CI of -0.09 (CI: -2.20 to 2.02) with high heterogeneity (I² = 98%), suggesting its potential as a diagnostic and prognostic biomarker. TNF-α and MMP-8 showed no significant differences (CIs: 4.54 and 2.71, respectively). This systematic review and meta-analysis emphasize saliva's potential in identifying RA biomarkers, especially IL-6, which is associated with the disease's pathogenesis. However, significant evidence heterogeneity necessitates larger, multicentric studies for validation
类风湿性关节炎（RA）是一种使人衰弱的慢性自身免疫性疾病。类风湿因子（RF）和抗瓜氨酸蛋白抗体（ACPA）等血液生物标志物缺乏早期诊断的敏感性和特异性，从而延误了治疗。本综述在强调需要新诊断工具的同时，还强调了唾液在开发类风湿关节炎生物标志物方面的前景。本系统综述和荟萃分析评估了唾液生物标志物在诊断和预后RA方面的有效性，审查了当前的证据，并提出了未来的研究方向。根据 PRISMA 2021 指南，我们使用 PubMed、Scopus、Web of Science 和 Google Scholar 进行了文献综述，以确定过去五年中有关 RA 患者唾液生物标记物与健康对照组比较的研究。综述侧重于原创性研究文章，并对报告了IL-6、IL-8、MMP-8和TNF-α等炎症标志物标准偏差值的研究进行了荟萃分析。荟萃分析包括11项研究，涉及394名RA患者和255名健康对照者，评估了作为RA生物标志物的IL-8、IL-6、MMP-8和TNF-α。IL-8的平均差异为7.32（CI：-5.48至20.13），无统计学意义，有利于对照组。IL-6的CI为-0.09（CI：-2.20至2.02），具有高度异质性（I² = 98%），表明其具有作为诊断和预后生物标志物的潜力。TNF-α和MMP-8无明显差异（CIs：分别为4.54和2.71）。本系统综述和荟萃分析强调了唾液在确定RA生物标志物方面的潜力，尤其是与疾病发病机制相关的IL-6。然而，由于证据存在明显的异质性，因此有必要进行更大规模的多中心研究来验证
{"title":"Potential of salivary biomarkers for diagnosing and prognosing rheumatoid arthritis: A systematic review and meta-analysis: Salivary biomarkers in Rheumatoid Arthritis patients – A systematic review with Meta-analysis","authors":"Anitha Krishnan Pandarathodiyil, Hema Shree Kasirajan, Suresh Vemuri, G.V. Naga Sai Sujai, Sivapathasundharam B, Ramya Ramadoss","doi":"10.1016/j.jormas.2024.102074","DOIUrl":"https://doi.org/10.1016/j.jormas.2024.102074","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disorder. Blood biomarkers, like rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs), lack the sensitivity and specificity for early diagnosis, delaying treatment. This review while highlighting the need for new diagnostic tools, emphasizes the promising avenue of saliva for developing RA biomarkers. This systematic review and meta-analysis assess the effectiveness of salivary biomarkers in the diagnosis and prognosis of RA, examining current evidence and proposing avenues for future research. A literature review following PRISMA 2021 guidelines was conducted using PubMed, Scopus, Web of Science, and Google Scholar to identify studies from the past five years on salivary biomarkers in RA patients compared to healthy controls. The review focused on original research articles, and meta-analysis was performed on studies reporting standard deviation values for inflammatory markers such as IL-6, IL-8, MMP-8, and TNF-alpha. The meta-analysis included eleven studies with 394 RA patients and 255 healthy controls, evaluating IL-8, IL-6, MMP-8, and TNF-α as RA biomarkers. IL-8 showed a mean difference of 7.32 (CI: -5.48 to 20.13), not statistically significant, favouring controls. IL-6 had a CI of -0.09 (CI: -2.20 to 2.02) with high heterogeneity (I² = 98%), suggesting its potential as a diagnostic and prognostic biomarker. TNF-α and MMP-8 showed no significant differences (CIs: 4.54 and 2.71, respectively). This systematic review and meta-analysis emphasize saliva's potential in identifying RA biomarkers, especially IL-6, which is associated with the disease's pathogenesis. However, significant evidence heterogeneity necessitates larger, multicentric studies for validation","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"199 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-12DOI: 10.1016/j.jormas.2024.102073
Tianyi Gu, Songxia Xia, Yuanliang Huang, Panxi Yu, Minghao Zhao, Jianjian Lu, Li Teng
Bone regeneration in the mandibular angle region after reduction mandibuloplasty may compromise the aesthetics of the lower face and thus lead to revision surgery. Bone quality is known to play an important role in osteogenesis. However, no study has evaluated the relationship between mandibular bone quality and bone regeneration volume. The bone density of the mandibular angle immediately after surgery (BD) was determined as the grey level in computed tomography (CT) images. Based on the immediate postoperative and long-term follow-up CT images, the volumes of the regenerated angle (V) and the regenerated outer cortex (V) were measured after model reconstruction, automatic alignment and Boolean operation. Correlation analyses were then performed between V and BD, V and BD. 23 patients (46 mandibular angles) were included in this study. The average BD was 907.09 ± 111.89 HU. The mean V was 201.66 (131.73–357.24) mm. Spearman correlation analysis revealed a positive correlation between BD and V ( = 0.5449, < 0.0001). The mean V was 236.23 ± 151.35 mm. Pearson correlation analysis found a negative correlation between BD and V ( = -0.3501, = 0.0171). CT images can provide a quantitative assessment of mandibular bone quality. BD may influence the volumes of bone regeneration in different areas of the mandibular angle portion after reduction mandibuloplasty, in the regenerated angle area positively and in the regenerated outer cortex region negatively. Therefore, slight over-grinding may be a choice to prevent secondary angulation.
下颌角缩小整形术后下颌角区域的骨再生可能会影响下面部的美观，从而导致翻修手术。众所周知，骨质在骨生成中起着重要作用。然而，还没有研究评估过下颌骨骨质与骨再生量之间的关系。下颌角术后即刻的骨密度（BD）是根据计算机断层扫描（CT）图像的灰度水平确定的。根据术后即刻和长期随访的 CT 图像，经过模型重建、自动配准和布尔运算，测量了再生角（V）和再生外皮层（V）的体积。然后在 V 和 BD、V 和 BD 之间进行相关性分析。本研究共纳入 23 名患者（46 个下颌角）。平均 BD 为 907.09 ± 111.89 HU。平均 V 值为 201.66 (131.73-357.24) mm。斯皮尔曼相关分析显示，BD 和 V 之间呈正相关（= 0.5449，< 0.0001）。平均 V 值为 236.23 ± 151.35 毫米。皮尔逊相关分析发现，BD 和 V 之间呈负相关（=-0.3501，=0.0171）。CT 图像可对下颌骨质量进行定量评估。BD 可能会影响下颌骨缩窄整形术后下颌角部分不同区域的骨再生量，对再生角区域有积极影响，对再生外皮质区域有消极影响。因此，轻微的过度磨削可能是防止继发性成角的一种选择。
{"title":"Relations between bone density from computed tomography and bone regeneration after reduction mandibuloplasty","authors":"Tianyi Gu, Songxia Xia, Yuanliang Huang, Panxi Yu, Minghao Zhao, Jianjian Lu, Li Teng","doi":"10.1016/j.jormas.2024.102073","DOIUrl":"https://doi.org/10.1016/j.jormas.2024.102073","url":null,"abstract":"Bone regeneration in the mandibular angle region after reduction mandibuloplasty may compromise the aesthetics of the lower face and thus lead to revision surgery. Bone quality is known to play an important role in osteogenesis. However, no study has evaluated the relationship between mandibular bone quality and bone regeneration volume. The bone density of the mandibular angle immediately after surgery (BD) was determined as the grey level in computed tomography (CT) images. Based on the immediate postoperative and long-term follow-up CT images, the volumes of the regenerated angle (V) and the regenerated outer cortex (V) were measured after model reconstruction, automatic alignment and Boolean operation. Correlation analyses were then performed between V and BD, V and BD. 23 patients (46 mandibular angles) were included in this study. The average BD was 907.09 ± 111.89 HU. The mean V was 201.66 (131.73–357.24) mm. Spearman correlation analysis revealed a positive correlation between BD and V ( = 0.5449, < 0.0001). The mean V was 236.23 ± 151.35 mm. Pearson correlation analysis found a negative correlation between BD and V ( = -0.3501, = 0.0171). CT images can provide a quantitative assessment of mandibular bone quality. BD may influence the volumes of bone regeneration in different areas of the mandibular angle portion after reduction mandibuloplasty, in the regenerated angle area positively and in the regenerated outer cortex region negatively. Therefore, slight over-grinding may be a choice to prevent secondary angulation.","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"190 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-11DOI: 10.1016/j.jormas.2024.102035
Xiaoqi Dong, Zhuoying Cai, Miaomiao Fang, Wanru Zhao, Yanming Liu
Effective management of oral cancer necessitates a multidisciplinary approach, with surgery playing a pivotal role in treatment. However, there are many risk factors during the perioperative period that affect postoperative recovery. This study aims to identify the risk factors influencing postoperative recovery in patients undergoing oral cancer surgery, thereby optimizing perioperative management. A retrospective cohort study was carried out in patients who underwent surgery for oral cancer at The Second Affiliated Hospital Of Zhejiang University School Of Medicine from Jan. to Dec. in 2023. Based on the median length of stay (LOS) of 20.42 days, we divided the study population into DL3W and DM3W groups (DL3W/DM3W: Discharged less/>3 weeks). The Predictor variables included sex, age, BMI, smoke, drink, education, settlement, surgery history, tumor history, intra-operative situation, flap details, pathologic stage, treatment and laboratory examination. The primary outcome was length of stay (LOS) defined as the days from the start of preoperative preparation to discharge from the hospital. Descriptive and inferential analyses were performed using the χ2 test, Fisher's exact test and t-test. A P value of 0.05 was deemed as an acceptable statistical significance level. The sample was composed of 103 subjects with a mean age of 59.45 (14.20) and 71 (68.9 %) were male. The median LOS was 20.42 ((range, 10–69) days. The baseline characteristics between the DL3W and DM3W groups were generally balanced. Factors associated with LOS were BMI (95 %CI 1.01–1.15, = 0.046), intraoperative blood loss (95 %CI 0.;99–1.00, = 0.002), flap source ( < 0.001), and postoperative fasting time (95 %CI 0.88–0.95, < 0.001). In the regression model, more intraoperative blood loss and longer postoperative fasting time were associated with increased. LOS and factors BMI and the use of forearm flap were associated with decreased LOS after adjusting the confounding factors. In the perioperative period for oral cancer patients, optimizing postoperative recovery may be achieved by carefully managing BMI, intraoperative blood loss, flap source, and postoperative fasting time.
{"title":"Risk factors for postoperative recovery in oral cancer surgery: A retrospective cohort study","authors":"Xiaoqi Dong, Zhuoying Cai, Miaomiao Fang, Wanru Zhao, Yanming Liu","doi":"10.1016/j.jormas.2024.102035","DOIUrl":"https://doi.org/10.1016/j.jormas.2024.102035","url":null,"abstract":"Effective management of oral cancer necessitates a multidisciplinary approach, with surgery playing a pivotal role in treatment. However, there are many risk factors during the perioperative period that affect postoperative recovery. This study aims to identify the risk factors influencing postoperative recovery in patients undergoing oral cancer surgery, thereby optimizing perioperative management. A retrospective cohort study was carried out in patients who underwent surgery for oral cancer at The Second Affiliated Hospital Of Zhejiang University School Of Medicine from Jan. to Dec. in 2023. Based on the median length of stay (LOS) of 20.42 days, we divided the study population into DL3W and DM3W groups (DL3W/DM3W: Discharged less/>3 weeks). The Predictor variables included sex, age, BMI, smoke, drink, education, settlement, surgery history, tumor history, intra-operative situation, flap details, pathologic stage, treatment and laboratory examination. The primary outcome was length of stay (LOS) defined as the days from the start of preoperative preparation to discharge from the hospital. Descriptive and inferential analyses were performed using the χ2 test, Fisher's exact test and t-test. A P value of 0.05 was deemed as an acceptable statistical significance level. The sample was composed of 103 subjects with a mean age of 59.45 (14.20) and 71 (68.9 %) were male. The median LOS was 20.42 ((range, 10–69) days. The baseline characteristics between the DL3W and DM3W groups were generally balanced. Factors associated with LOS were BMI (95 %CI 1.01–1.15, = 0.046), intraoperative blood loss (95 %CI 0.;99–1.00, = 0.002), flap source ( < 0.001), and postoperative fasting time (95 %CI 0.88–0.95, < 0.001). In the regression model, more intraoperative blood loss and longer postoperative fasting time were associated with increased. LOS and factors BMI and the use of forearm flap were associated with decreased LOS after adjusting the confounding factors. In the perioperative period for oral cancer patients, optimizing postoperative recovery may be achieved by carefully managing BMI, intraoperative blood loss, flap source, and postoperative fasting time.","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"49 1","pages":"102035"},"PeriodicalIF":2.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-09DOI: 10.1016/j.jormas.2024.102069
Cheryl Ker Jia Lee,Chee Weng Yong,Suat Li Tan,Ji An Seah,Ming Tak Chew,Yijin Ren
Three-dimensional (3D) printing has slowly become an integral part of orthognathic surgery. However, there is a lack of studies evaluating accuracy of orthognathic surgical splints fabricated from subtractive milling versus additive 3D printing. The primary aim of this in vitro study was to compare the differences in trueness between milled and 3D-printed splints, while the secondary aim was to compare the differences in clinical fit of these splints. A sample of eight patients was selected, and STL files of the final orthognathic surgical splint were used to fabricate three splints for each of the eight cases. The first splint was fabricated by subtractive milling (SM), whereas the second and third splints were 3D printed with Digital Light Processing (DLP) and Laser Stereolithography (SLA), respectively. Paired superimposition of scans was performed using a reference model. The clinical fit of the splints to the printed models was also assessed. The mean root mean square (RMS) deviations for the SM, SLA, and DLP were 0.11 ± 0.02, 0.16 ± 0.02 and 0.14 ± 0.02 respectively. The post-hoc analysis showed that the SM splints had the highest accuracy (p<0.01). However, DLP splints showed the best clinical fit, followed by SM and SLA. In conclusion, splints fabricated by SM were more accurate than those fabricated by 3D printing, although this difference may not be clinically significant. The site, rather than the magnitude of the errors, may have a greater effect on the clinical usability of splints. In general, SM and DLP splints demonstrated a good clinical fit and were suitable for the fabrication of surgical splints.
三维（3D）打印已逐渐成为正颌外科手术中不可或缺的一部分。然而，目前还缺乏对用减法铣削和增法三维打印制作的正颌外科夹板的精确度进行评估的研究。这项体外研究的主要目的是比较铣制夹板和 3D 打印夹板在真实度上的差异，次要目的是比较这些夹板在临床贴合度上的差异。研究选取了八名患者作为样本，并使用最终正颌手术夹板的 STL 文件为八个病例分别制作了三个夹板。第一块夹板是用减法铣削（SM）制作的，而第二块和第三块夹板则分别是用数字光处理（DLP）和激光立体光刻（SLA）三维打印的。使用参考模型对扫描结果进行配对叠加。此外，还对夹板与打印模型的临床拟合度进行了评估。SM、SLA 和 DLP 的平均均方根（RMS）偏差分别为 0.11 ± 0.02、0.16 ± 0.02 和 0.14 ± 0.02。事后分析表明，SM 夹板的准确度最高（p<0.01）。然而，DLP 夹板显示出最佳的临床贴合度，其次是 SM 和 SLA。总之，用 SM 制作的夹板比用 3D 打印制作的夹板更准确，尽管这种差异在临床上可能并不显著。对夹板临床可用性影响更大的可能是部位，而不是误差的大小。总的来说，SM 和 DLP 夹板具有良好的临床适应性，适合用于制作手术夹板。
{"title":"Accuracy and clinical fit of milled versus rapid prototyped orthognathic surgical splints.","authors":"Cheryl Ker Jia Lee,Chee Weng Yong,Suat Li Tan,Ji An Seah,Ming Tak Chew,Yijin Ren","doi":"10.1016/j.jormas.2024.102069","DOIUrl":"https://doi.org/10.1016/j.jormas.2024.102069","url":null,"abstract":"Three-dimensional (3D) printing has slowly become an integral part of orthognathic surgery. However, there is a lack of studies evaluating accuracy of orthognathic surgical splints fabricated from subtractive milling versus additive 3D printing. The primary aim of this in vitro study was to compare the differences in trueness between milled and 3D-printed splints, while the secondary aim was to compare the differences in clinical fit of these splints. A sample of eight patients was selected, and STL files of the final orthognathic surgical splint were used to fabricate three splints for each of the eight cases. The first splint was fabricated by subtractive milling (SM), whereas the second and third splints were 3D printed with Digital Light Processing (DLP) and Laser Stereolithography (SLA), respectively. Paired superimposition of scans was performed using a reference model. The clinical fit of the splints to the printed models was also assessed. The mean root mean square (RMS) deviations for the SM, SLA, and DLP were 0.11 ± 0.02, 0.16 ± 0.02 and 0.14 ± 0.02 respectively. The post-hoc analysis showed that the SM splints had the highest accuracy (p<0.01). However, DLP splints showed the best clinical fit, followed by SM and SLA. In conclusion, splints fabricated by SM were more accurate than those fabricated by 3D printing, although this difference may not be clinically significant. The site, rather than the magnitude of the errors, may have a greater effect on the clinical usability of splints. In general, SM and DLP splints demonstrated a good clinical fit and were suitable for the fabrication of surgical splints.","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"9 1","pages":"102069"},"PeriodicalIF":2.2,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Occult metastasis is not easily detected clinically or radiographically. Various methods have been applied for neck control for clinically N0 via elective neck dissection (END), wait and watch (W&W) and sentinel lymph node biopsy (SLNB). The main aim of this study is to investigate the prevalence of occult cervical lymph nodes metastasis in cN0 in oral squamous cell carcinoma, to investigate and compare the disease-free state and overall survival rate between occult metastasis and the non-occult group that presented at the oral and maxillofacial surgery clinic, Faculty of Dentistry, Universiti Malaya. This is a retrospective study involving 48 patients with complete data from 2008 to 2019. Data collected includes socio-demographic and clinicopathologic factors. Descriptive analysis was performed and Kaplan-Meier analysis was used to compare disease-free status and overall survival period between occult and non-occult metastases groups. The prevalence of occult metastasis in oral squamous cell carcinoma (OSCC) was low at 8.3% but it became 100% on OSCC tongue. The main tumor site for occult metastasis originated from the oral tongue with T2 size. Non-occult group had better overall survival rate comparing to occult metastasis group and the advanced group. Therefore, END is recommended particularly for N0 OSCC tongue.
{"title":"PREVALENCE OF OCCULT CERVICAL LYMPH NODES METASTASIS IN CN0 IN ORAL SQUAMOUS CELL CARCINOMA (OSCC).","authors":"Fadhli Reza Zainal,Zainal Ariff Abdul Rahman,Daniel Lim Khim Hock,Chan Sze Seng,Tan Chuey Chuan","doi":"10.1016/j.jormas.2024.102070","DOIUrl":"https://doi.org/10.1016/j.jormas.2024.102070","url":null,"abstract":"Occult metastasis is not easily detected clinically or radiographically. Various methods have been applied for neck control for clinically N0 via elective neck dissection (END), wait and watch (W&W) and sentinel lymph node biopsy (SLNB). The main aim of this study is to investigate the prevalence of occult cervical lymph nodes metastasis in cN0 in oral squamous cell carcinoma, to investigate and compare the disease-free state and overall survival rate between occult metastasis and the non-occult group that presented at the oral and maxillofacial surgery clinic, Faculty of Dentistry, Universiti Malaya. This is a retrospective study involving 48 patients with complete data from 2008 to 2019. Data collected includes socio-demographic and clinicopathologic factors. Descriptive analysis was performed and Kaplan-Meier analysis was used to compare disease-free status and overall survival period between occult and non-occult metastases groups. The prevalence of occult metastasis in oral squamous cell carcinoma (OSCC) was low at 8.3% but it became 100% on OSCC tongue. The main tumor site for occult metastasis originated from the oral tongue with T2 size. Non-occult group had better overall survival rate comparing to occult metastasis group and the advanced group. Therefore, END is recommended particularly for N0 OSCC tongue.","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"10 1","pages":"102070"},"PeriodicalIF":2.2,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-07DOI: 10.1016/j.jormas.2024.102068
Ricardo Grillo,Philippi Machado Dos Reis,Richard Gravalos,Henrique Tostes
OBJECTIVESThis technical note introduces a novel concept of a alveolar inferior nerve protector guide during orthognathic surgery based on a free-software creation and printing.TECHNICAL NOTEOrthognathic surgery using Virtual Surgical Planning software like Dolphin Imaging ® v 11.9 facilitated a bimaxillary procedure with mandible advancement and occlusal plane correction, later followed by 3D printing of splints. The process involved importing a composite skull with osteotomies into Blender ® software, where solids were added and edited to match Dolphin's osteotomies, ensuring bone contact without distortion. The guide creation was performed adhering to bilateral sagittal split osteotomy principles, maintaining precision, resulting in preserved inferior alveolar nerve and faster operation times compared to non-guided procedures, as demonstrated by postoperative CT scans.CONCLUSIONSIntegrating advanced tools like Blender software into maxillofacial surgery represents a significant advancement. Despite challenges like the absence of specific manuals for this purpose in Blender, using such software offers innovative and cost-effective solutions. Developing user-friendly resources tailored to surgical applications such as a protector guide within Blender can enhance its usability and improve surgical outcomes and patient care, leading to groundbreaking advancements in maxillofacial surgery.
技术注释使用Dolphin Imaging ® v 11.9等虚拟手术规划软件进行正颌外科手术时，可进行下颌骨前移和咬合面矫正的双颌手术，随后进行夹板的三维打印。该过程包括将带有截骨的复合头骨导入Blender ®软件，在其中添加实体并进行编辑，以与Dolphin的截骨相匹配，确保骨接触不变形。正如术后CT扫描所显示的，与无引导手术相比，该引导创建过程遵循了双侧矢状劈开截骨原则，保持了精确性，从而保留了下牙槽神经并缩短了手术时间。尽管存在一些挑战，如 Blender 中没有专门的使用手册，但使用此类软件可以提供创新且经济高效的解决方案。开发适合外科应用的用户友好型资源（如 Blender 中的保护器指南）可以提高其可用性，改善手术效果和患者护理，从而在颌面外科领域取得突破性进展。
{"title":"A simple and free software-based inferior alveolar nerve protector surgical guide in bilateral sagittal split osteotomy.","authors":"Ricardo Grillo,Philippi Machado Dos Reis,Richard Gravalos,Henrique Tostes","doi":"10.1016/j.jormas.2024.102068","DOIUrl":"https://doi.org/10.1016/j.jormas.2024.102068","url":null,"abstract":"OBJECTIVESThis technical note introduces a novel concept of a alveolar inferior nerve protector guide during orthognathic surgery based on a free-software creation and printing.TECHNICAL NOTEOrthognathic surgery using Virtual Surgical Planning software like Dolphin Imaging ® v 11.9 facilitated a bimaxillary procedure with mandible advancement and occlusal plane correction, later followed by 3D printing of splints. The process involved importing a composite skull with osteotomies into Blender ® software, where solids were added and edited to match Dolphin's osteotomies, ensuring bone contact without distortion. The guide creation was performed adhering to bilateral sagittal split osteotomy principles, maintaining precision, resulting in preserved inferior alveolar nerve and faster operation times compared to non-guided procedures, as demonstrated by postoperative CT scans.CONCLUSIONSIntegrating advanced tools like Blender software into maxillofacial surgery represents a significant advancement. Despite challenges like the absence of specific manuals for this purpose in Blender, using such software offers innovative and cost-effective solutions. Developing user-friendly resources tailored to surgical applications such as a protector guide within Blender can enhance its usability and improve surgical outcomes and patient care, leading to groundbreaking advancements in maxillofacial surgery.","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"10 1","pages":"102068"},"PeriodicalIF":2.2,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OBJECTIVESThe pathogenesis and progressive behavior of head, neck, oral and maxillofacial (HNOMF) squamous cell carcinoma (SCC) has been suggested to be a multistep and multifactorial procedure that necessitates epithelial hyperplasia, epithelial dysplasia, micro invasive squamous cell carcinoma (MISCC) and early invasive squamous cell carcinoma (EISCC); EISCC and MISCC might have a completely different behavior and development process. There are only a limited number of reported HNOMF cases of EISCC or MISCC. There are still no guidelines for the treatment of EISCC and MISCC lesions in the HNOMF regions.MATERIAL AND METHODSThis systematic review was conducted to gather all surgical and non-surgical treatments for EISCC and MISCC lesions in the HNOMF. The study question according to the PICO format was as followed: clinical and histopathological results (O) of all types of treatments (I) for patients with EISCC and MISCC lesions in HNOMF (P) compared to untreated lesions (C). Medline, Scopus, and Google Scholar were searched and the search was limited to English-language.RESULTSEight clinical human studies were included. Photodynamic therapy (PDT) after topical application of methyl aminolevulinate (MAL-PDT) and topical Imiquimod 5% cream both had remarkable outcomes.CONCLUSIONSHowever, due to the very limited number of studies conducted on the treatment methods of MISCC and EISCC in the HNOMF regions, further studies are necessary to provide reliability for non-surgical treatment methods.
{"title":"Comparative Evaluations of Different Surgical and Non-surgical Treatment Methods for Early Invasive and Micro Invasive Squamous Cell Carcinoma in the Oral and Maxillofacial Regions: A Systematic Review.","authors":"Amir-Ali Yousefi-Koma,Sahar Baniameri,Hannaneh Yousefi-Koma,Fatemeh Mashhadiabbas","doi":"10.1016/j.jormas.2024.102034","DOIUrl":"https://doi.org/10.1016/j.jormas.2024.102034","url":null,"abstract":"OBJECTIVESThe pathogenesis and progressive behavior of head, neck, oral and maxillofacial (HNOMF) squamous cell carcinoma (SCC) has been suggested to be a multistep and multifactorial procedure that necessitates epithelial hyperplasia, epithelial dysplasia, micro invasive squamous cell carcinoma (MISCC) and early invasive squamous cell carcinoma (EISCC); EISCC and MISCC might have a completely different behavior and development process. There are only a limited number of reported HNOMF cases of EISCC or MISCC. There are still no guidelines for the treatment of EISCC and MISCC lesions in the HNOMF regions.MATERIAL AND METHODSThis systematic review was conducted to gather all surgical and non-surgical treatments for EISCC and MISCC lesions in the HNOMF. The study question according to the PICO format was as followed: clinical and histopathological results (O) of all types of treatments (I) for patients with EISCC and MISCC lesions in HNOMF (P) compared to untreated lesions (C). Medline, Scopus, and Google Scholar were searched and the search was limited to English-language.RESULTSEight clinical human studies were included. Photodynamic therapy (PDT) after topical application of methyl aminolevulinate (MAL-PDT) and topical Imiquimod 5% cream both had remarkable outcomes.CONCLUSIONSHowever, due to the very limited number of studies conducted on the treatment methods of MISCC and EISCC in the HNOMF regions, further studies are necessary to provide reliability for non-surgical treatment methods.","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"29 1","pages":"102034"},"PeriodicalIF":2.2,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-07DOI: 10.1016/j.jormas.2024.102046
Shi-Long Zhang,Jia-Wen Tian,Jun Jia,Zi-Li Yu
Gingival squamous cell carcinoma (SCC) of the posterior mandible often requires marginal resection of the mandible in conventional surgery. However, the posterior location of the lesion can limit surgical visibility, which is critical for complete tumor removal and minimizing recurrence. Typically, marginal resection of the posterior mandible is achieved through a midline lower lip incision and mental nerve transection, providing adequate exposure but resulting in nerve damage, lip numbness, and facial scarring. In this paper, we describe a case using a submandibular incision for neck dissection, extending from the mandibular angle to the posterior mental foramen, to fully expose the posterior mandible. The intraoral incision, extending 1 cm beyond the tumor margin, connected with the submandibular incision. Under direct vision, we performed a marginal resection of the mandible, preserving the inferior alveolar neurovascular bundle and the mental nerve, and maintaining at least 1 cm of the inferior mandibular margin. This technique achieved complete tumor removal while preserving mental nerve function and lower lip integrity, reducing surgical difficulty and patient trauma. This approach maintains nerve function and aesthetics as much as possible, with a faster postoperative recovery. In treating gingival SCC of the posterior mandible, it is essential to preserve surrounding healthy tissue and critical anatomical structures, minimizing postoperative complications while ensuring complete tumor resection.
{"title":"A New Approach: Cervical Approach for Marginal Resection of the Posterior Mandible.","authors":"Shi-Long Zhang,Jia-Wen Tian,Jun Jia,Zi-Li Yu","doi":"10.1016/j.jormas.2024.102046","DOIUrl":"https://doi.org/10.1016/j.jormas.2024.102046","url":null,"abstract":"Gingival squamous cell carcinoma (SCC) of the posterior mandible often requires marginal resection of the mandible in conventional surgery. However, the posterior location of the lesion can limit surgical visibility, which is critical for complete tumor removal and minimizing recurrence. Typically, marginal resection of the posterior mandible is achieved through a midline lower lip incision and mental nerve transection, providing adequate exposure but resulting in nerve damage, lip numbness, and facial scarring. In this paper, we describe a case using a submandibular incision for neck dissection, extending from the mandibular angle to the posterior mental foramen, to fully expose the posterior mandible. The intraoral incision, extending 1 cm beyond the tumor margin, connected with the submandibular incision. Under direct vision, we performed a marginal resection of the mandible, preserving the inferior alveolar neurovascular bundle and the mental nerve, and maintaining at least 1 cm of the inferior mandibular margin. This technique achieved complete tumor removal while preserving mental nerve function and lower lip integrity, reducing surgical difficulty and patient trauma. This approach maintains nerve function and aesthetics as much as possible, with a faster postoperative recovery. In treating gingival SCC of the posterior mandible, it is essential to preserve surrounding healthy tissue and critical anatomical structures, minimizing postoperative complications while ensuring complete tumor resection.","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"120 1","pages":"102046"},"PeriodicalIF":2.2,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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