Pub Date : 2026-03-01Epub Date: 2025-10-24DOI: 10.1016/j.jormas.2025.102633
Rafael Martín-Granizo , Luis Vicente González , Daniel Jerez-Frederick , Luciano del Santo , Raúl González-García
Objective
To complete the new classification of procedures and techniques to be performed in TMJ arthroscopy, with new techniques that have recently appeared and to add a new separate level.
Material and methods
The authors propose a new level and new subclassifications in TMJ arthroscopy, in order to be able to use the same language between TMJ arthroscopists and obtain more consistent results in the studies and analyses performed.
Results
Category and level I (lysis and lavage) is maintained while levels II (operative) and level III (discopexy) of TMJ arthroscopy are modified. Level III is divided according to the discopexy technique used; in IIIa for non-rigid sutures, IIIb for semi-rigid sutures and IIIc for rigid techniques. Furthermore, level IV of arthroscopy is also proposed, which would be that one carried out specifically and with special technique in the lower joint space.
Conclusions
It is important that all specialists in arthroscopic treatment of TMJ use the same classification system for the different techniques to obtain homogeneous, consistent and valid results in the different studies. This classification is not exclusive by levels, nor is it based on surgical difficulty, or the instrumentation of the techniques used.
{"title":"An update in the new classification of levels in arthroscopic techniques of the TMJ","authors":"Rafael Martín-Granizo , Luis Vicente González , Daniel Jerez-Frederick , Luciano del Santo , Raúl González-García","doi":"10.1016/j.jormas.2025.102633","DOIUrl":"10.1016/j.jormas.2025.102633","url":null,"abstract":"<div><h3>Objective</h3><div>To complete the new classification of procedures and techniques to be performed in TMJ arthroscopy, with new techniques that have recently appeared and to add a new separate level.</div></div><div><h3>Material and methods</h3><div>The authors propose a new level and new subclassifications in TMJ arthroscopy, in order to be able to use the same language between TMJ arthroscopists and obtain more consistent results in the studies and analyses performed.</div></div><div><h3>Results</h3><div>Category and level I (lysis and lavage) is maintained while levels II (operative) and level III (discopexy) of TMJ arthroscopy are modified. Level III is divided according to the discopexy technique used; in IIIa for non-rigid sutures, IIIb for semi-rigid sutures and IIIc for rigid techniques. Furthermore, level IV of arthroscopy is also proposed, which would be that one carried out specifically and with special technique in the lower joint space.</div></div><div><h3>Conclusions</h3><div>It is important that all specialists in arthroscopic treatment of TMJ use the same classification system for the different techniques to obtain homogeneous, consistent and valid results in the different studies. This classification is not exclusive by levels, nor is it based on surgical difficulty, or the instrumentation of the techniques used.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102633"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-11-14DOI: 10.1016/j.jormas.2025.102646
Priya Thomas , Abilasha Ramasubramanian , Durairaj Sekar
Aim
To investigate the regulatory role of miR-20a and its basal levels in the STAT3/IL-6 pathway in OSCC tissues, and assessing the concomitant role of miR-20a and STAT3, particularly the miR-20a’s inhibitory role on STAT3 in OSCC progression.
Materials & methods
Biopsied specimens were obtained from 63 OSCC individuals. RNA isolation was performed using TRIzol, and cDNA was generated for quantitative real-time PCR to analyze miR-20a, STAT3, and IL-6 levels across paired OSCC and adjacent noncancerous tissues. The protein expression of STAT3 and IL-6 were evaluated using western blot in both normal and OSCC samples. Data were transferred to Microsoft Excel, and statistical analyses, including t-tests and ANOVA (p < 0.05), were conducted using GraphPad Prism. Clinicopathological correlation between miR-20a, STAT3, and IL-6 expression with tumor grade and histological staging were also explored.
Results
In OSCC tissues, STAT3 and IL-6 mRNA and protein expressions were significantly higher, while miR-20a mRNA expression was significantly lower compared to corresponding nontumorous tissue. Analysis revealed that OSCC tissue samples exhibited marked difference in the levels of miR-20a, STAT3, and IL-6 expression, with very high statistical significance (p < 0.0001). An inverse relationship was noted: as miR-20a levels decreased with increasing tumor grade and clinical stage, STAT3 and IL-6 expressions varied.
Conclusion
This study shows significant upregulation of STAT3 and IL-6 and downregulation of miR-20a in OSCC tissues samples suggesting miR-20a’s potential as a tumor suppressor.
Clinical significance
miR-20a expression inversely correlates with STAT3 and IL-6 levels, declining with tumor progression and playing a key part in regulating the STAT3/IL-6 pathway. The observed characteristics of miR-20a indicate its potential application in OSCC diagnostics and targeted therapeutics. The antagonism between miR-20a and STAT3 emphasizes the value of miR-20a-based replacement and immunotherapy in personalized treatment strategies. Additionally, the expression profiles of miR-20a, STAT3, and IL-6 may function as potential indicators for early diagnosis and therapeutic intervention.
{"title":"Delineating the regulatory axis of miR-20a, STAT3, and IL-6 in oral squamous cell carcinoma","authors":"Priya Thomas , Abilasha Ramasubramanian , Durairaj Sekar","doi":"10.1016/j.jormas.2025.102646","DOIUrl":"10.1016/j.jormas.2025.102646","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate the regulatory role of miR-20a and its basal levels in the STAT3/IL-6 pathway in OSCC tissues, and assessing the concomitant role of miR-20a and STAT3, particularly the miR-20a’s inhibitory role on STAT3 in OSCC progression.</div></div><div><h3>Materials & methods</h3><div>Biopsied specimens were obtained from 63 OSCC individuals. RNA isolation was performed using TRIzol, and cDNA was generated for quantitative real-time PCR to analyze miR-20a, STAT3, and IL-6 levels across paired OSCC and adjacent noncancerous tissues. The protein expression of STAT3 and IL-6 were evaluated using western blot in both normal and OSCC samples. Data were transferred to Microsoft Excel, and statistical analyses, including <em>t</em>-tests and ANOVA (<em>p</em> < 0.05), were conducted using GraphPad Prism. Clinicopathological correlation between miR-20a, STAT3, and IL-6 expression with tumor grade and histological staging were also explored.</div></div><div><h3>Results</h3><div>In OSCC tissues, STAT3 and IL-6 mRNA and protein expressions were significantly higher, while miR-20a mRNA expression was significantly lower compared to corresponding nontumorous tissue. Analysis revealed that OSCC tissue samples exhibited marked difference in the levels of miR-20a, STAT3, and IL-6 expression, with very high statistical significance (<em>p</em> < 0.0001). An inverse relationship was noted: as miR-20a levels decreased with increasing tumor grade and clinical stage, STAT3 and IL-6 expressions varied.</div></div><div><h3>Conclusion</h3><div>This study shows significant upregulation of STAT3 and IL-6 and downregulation of miR-20a in OSCC tissues samples suggesting miR-20a’s potential as a tumor suppressor.</div></div><div><h3>Clinical significance</h3><div>miR-20a expression inversely correlates with STAT3 and IL-6 levels, declining with tumor progression and playing a key part in regulating the STAT3/IL-6 pathway. The observed characteristics of miR-20a indicate its potential application in OSCC diagnostics and targeted therapeutics. The antagonism between miR-20a and STAT3 emphasizes the value of miR-20a-based replacement and immunotherapy in personalized treatment strategies. Additionally, the expression profiles of miR-20a, STAT3, and IL-6 may function as potential indicators for early diagnosis and therapeutic intervention.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102646"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-10-04DOI: 10.1016/j.jormas.2025.102594
Gowri Sivaramakrishnan , Kannan Sridharan , Mohammed Abdulla AlMuharraqi
Background
Accurate classification of oral squamous cell carcinoma (OSCC) and oral potentially malignant lesions (OPLs) is challenging due to histopathological variability and limited predictive biomarkers. DNA methylation offers a promising molecular signature, but its utility for tissue classification remains underexplored.
Methods
We harmonized publicly available DNA methylation datasets (GSE97784 and GSE204943; n = 142) and selected the top 100 most variable CpG sites (variance 0.074–0.117) for analysis. Eight supervised machine learning (ML) models—logistic regression, random forest (RF), support vector machine (SVM), extreme gradient boosting (XGBoost), k-nearest neighbors (kNN), Naive Bayes, gradient boosting machine (GBM), and neural network (NN)—were trained using 10-fold cross-validation. Principal component analysis was performed to assess data dimensionality.
Results
High-variance CpG sites were predominantly located within gene bodies and clustered on chromosomes 1, 2, and 6. PCA revealed complex, high-dimensional methylation patterns requiring 55 components to capture 90 % of variance. Overall, RF achieved the highest accuracy (78 %) and AUC-ROC (0.84), followed by GBM (76 %) and XGBoost. Tumor and normal tissues were classified with relatively high sensitivity and specificity, while OPLs were difficult to detect, showing low sensitivity (<50 %) across all models. GBM performed best for normal tissue detection, and Naive Bayes slightly outperformed for tumor F1-score, but RF offered the most balanced performance across classes.
Conclusions
Ensemble ML models, particularly RF and GBM, demonstrate proof-of-concept potential for DNA methylation-based classification of oral tissues. While tumor and normal classification is robust, OPL detection remains challenging, highlighting the need for larger, balanced datasets and complementary biomarkers to improve early detection and clinical utility.
背景：由于组织病理学变异性和有限的预测性生物标志物，口腔鳞状细胞癌（OSCC）和口腔潜在恶性病变（opl）的准确分类具有挑战性。DNA甲基化提供了一种很有前途的分子标记，但其在组织分类方面的应用仍未得到充分探索。方法：我们统一了公开的DNA甲基化数据集（GSE97784和GSE204943； n = 142），并选择了前100个变化最大的CpG位点（方差0.074-0.117）进行分析。八个监督机器学习（ML）模型-逻辑回归，随机森林（RF），支持向量机（SVM），极端梯度增强（XGBoost）， k近邻（kNN），朴素贝叶斯，梯度增强机（GBM）和神经网络(NN)-使用10倍交叉验证进行训练。主成分分析评估数据维度。结果：高变异CpG位点主要位于基因体内，聚集在1、2和6号染色体上。PCA揭示了复杂的高维甲基化模式，需要55个成分来捕获90%的方差。总体而言，RF达到了最高的准确度（78%）和AUC-ROC(0.84)，其次是GBM（76%）和XGBoost。肿瘤和正常组织的分类具有相对较高的灵敏度和特异性，而opl难以检测，灵敏度较低(结论：集合ML模型，特别是RF和GBM，证明了基于DNA甲基化的口腔组织分类的概念验证潜力。虽然肿瘤和正常分类是稳健的，但OPL检测仍然具有挑战性，强调需要更大，平衡的数据集和互补的生物标志物，以提高早期检测和临床应用。
{"title":"DNA methylation-based machine learning models for classification of oral cancer and potentially malignant lesions: A proof-of-concept study","authors":"Gowri Sivaramakrishnan , Kannan Sridharan , Mohammed Abdulla AlMuharraqi","doi":"10.1016/j.jormas.2025.102594","DOIUrl":"10.1016/j.jormas.2025.102594","url":null,"abstract":"<div><h3>Background</h3><div>Accurate classification of oral squamous cell carcinoma (OSCC) and oral potentially malignant lesions (OPLs) is challenging due to histopathological variability and limited predictive biomarkers. DNA methylation offers a promising molecular signature, but its utility for tissue classification remains underexplored.</div></div><div><h3>Methods</h3><div>We harmonized publicly available DNA methylation datasets (GSE97784 and GSE204943; <em>n</em> = 142) and selected the top 100 most variable CpG sites (variance 0.074–0.117) for analysis. Eight supervised machine learning (ML) models—logistic regression, random forest (RF), support vector machine (SVM), extreme gradient boosting (XGBoost), k-nearest neighbors (kNN), Naive Bayes, gradient boosting machine (GBM), and neural network (NN)—were trained using 10-fold cross-validation. Principal component analysis was performed to assess data dimensionality.</div></div><div><h3>Results</h3><div>High-variance CpG sites were predominantly located within gene bodies and clustered on chromosomes 1, 2, and 6. PCA revealed complex, high-dimensional methylation patterns requiring 55 components to capture 90 % of variance. Overall, RF achieved the highest accuracy (78 %) and AUC-ROC (0.84), followed by GBM (76 %) and XGBoost. Tumor and normal tissues were classified with relatively high sensitivity and specificity, while OPLs were difficult to detect, showing low sensitivity (<50 %) across all models. GBM performed best for normal tissue detection, and Naive Bayes slightly outperformed for tumor F1-score, but RF offered the most balanced performance across classes.</div></div><div><h3>Conclusions</h3><div>Ensemble ML models, particularly RF and GBM, demonstrate proof-of-concept potential for DNA methylation-based classification of oral tissues. While tumor and normal classification is robust, OPL detection remains challenging, highlighting the need for larger, balanced datasets and complementary biomarkers to improve early detection and clinical utility.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102594"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-11-16DOI: 10.1016/j.jormas.2025.102659
Sara Mohamed Ali , Mohamed Hossam Eldin Elmallahy , Amira Mohamed Gamal Eldeen , Seham Ahmed Abdel Ghani
Objectives
Oral squamous cell carcinoma (OSCC) is the leading type of cancer found in the head and neck area with a low survival rate. Gold nanoparticles (GNPs) show promise as an alternative cancer treatment due to their photothermal properties. The study investigated the in vitro effects of GNPs on oral cancer cells, focusing on their photothermal impact by analyzing the expression levels of Caspase-8, Cytochrome C, and C-Myc, both with and without laser application.
Methods
The study included four groups: a control group with no treatment, and three treatment groups, doxorubicin (DOX), GNSCs, and GNSCs with laser exposure. Key parameters were measured, including the mode of cell death via fluorescence staining, Cytochrome-C and Caspase-8 expression using ELISA, and C-Myc oncogene expression through PCR.
Results
The study found that GNSCs with laser exposure significantly increased apoptosis in oral cancer cells compared to GNSCs alone. DOX treatment reduced cell viability and increased apoptosis by elevating Cytochrome C and Caspase-8 expression. While GNSCs alone had no significant effect, combining GNSCs with laser exposure enhanced Caspase-8 levels. Both DOX and GNSCs with laser suppressed C-Myc expression, with DOX being more effective.
Conclusion
Photothermal therapy using GNSCs combined with laser treatment shows promise as an alternative to chemotherapy and radiotherapy by inducing apoptosis through enhanced Caspase-8 activity and reduced C-Myc expression, although it is less effective than DOX in promoting Cytochrome C release and suppressing C-Myc.
{"title":"An in vitro evaluation of photothermal effect of gold nanoparticles on oral squamous cell carcinoma","authors":"Sara Mohamed Ali , Mohamed Hossam Eldin Elmallahy , Amira Mohamed Gamal Eldeen , Seham Ahmed Abdel Ghani","doi":"10.1016/j.jormas.2025.102659","DOIUrl":"10.1016/j.jormas.2025.102659","url":null,"abstract":"<div><h3>Objectives</h3><div>Oral squamous cell carcinoma (OSCC) is the leading type of cancer found in the head and neck area with a low survival rate. Gold nanoparticles (GNPs) show promise as an alternative cancer treatment due to their photothermal properties. The study investigated the in vitro effects of GNPs on oral cancer cells, focusing on their photothermal impact by analyzing the expression levels of Caspase-8, Cytochrome C, and C-Myc, both with and without laser application.</div></div><div><h3>Methods</h3><div>The study included four groups: a control group with no treatment, and three treatment groups, doxorubicin (DOX), GNSCs, and GNSCs with laser exposure. Key parameters were measured, including the mode of cell death via fluorescence staining, Cytochrome-C and Caspase-8 expression using ELISA, and C-Myc oncogene expression through PCR.</div></div><div><h3>Results</h3><div>The study found that GNSCs with laser exposure significantly increased apoptosis in oral cancer cells compared to GNSCs alone. DOX treatment reduced cell viability and increased apoptosis by elevating Cytochrome C and Caspase-8 expression. While GNSCs alone had no significant effect, combining GNSCs with laser exposure enhanced Caspase-8 levels. Both DOX and GNSCs with laser suppressed C-Myc expression, with DOX being more effective.</div></div><div><h3>Conclusion</h3><div>Photothermal therapy using GNSCs combined with laser treatment shows promise as an alternative to chemotherapy and radiotherapy by inducing apoptosis through enhanced Caspase-8 activity and reduced C-Myc expression, although it is less effective than DOX in promoting Cytochrome C release and suppressing C-Myc.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102659"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145551873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-10-10DOI: 10.1016/j.jormas.2025.102607
Federica Sobrero , Fabio Roccia , Gian Battista Bottini , Maximilian Goetzinger , Euan Rae , Sean Laverick , Carlo Strada , Guglielmo Ramieri , Constantinus Politis , Kathia Dubron , Anamaria Sivrić , Mario Kordić , Sajjad Abdur Rahman , Tabishur Rahman , Valfrido Antonio Pereira-Filho , Luis Fernando de Oliveira Gorla , Timothy Aladelusi , Karpal Singh Sohal , Marko Lazíc , Vitomir S. Konstantinovic , Anže Birk
OBJECTIVE(S)
Paediatric frontal fractures are uncommon injuries that may lead to significant complications. This study aimed to analyse patterns, surgical management, and outcomes of paediatric frontal sinus fractures in 14 maxillofacial centers worldwide.
METHODS
This multicentric retrospective study included patients ≤ 16 years of age operated for frontal fractures from January 2011 and December 2022. Collected data included: age, sex, cause of injury, site and type of fracture, surgical approach, nasofrontal outflow tract (NFOT) involvement, treatment, and outcome. Patients were divided based on the absence (group A) or presence (group B) of frontal sinus pneumatisation. Minimum follow-up was 6 months.
RESULTS
Thirty-two patients (mean age, 11.5 years) were included. Road traffic accidents were the main cause of injury (50%). In group A, 5/6 patients underwent open reduction and internal fixation (ORIF). In group B, 15 patients reported an isolated anterior table fracture, fixated with ORIF in 88% of cases. Nine patients reported combined anterior + posterior table fractures, 67% managed with anterior table fixation and cranialisation. One patient had an isolated posterior table fracture and underwent cranialisation. NFOT involvement was statistically associated with combined fractures (67%) (p=0.028) and managed with obliteration in 8/9 cases. Residual contour deformities of the frontal convexity were the most frequent complication (19%).
CONCLUSION
The surgical management varied by fracture site and sinus pneumatisation. Clinical outcomes were generally favourable, with residual contour deformities being the most common complications. Centers showed consistent approaches, but further multicenter studies are needed to establish definitive treatment strategies.
{"title":"Surgical management of paediatric frontal fractures with and without sinus pneumatisation: a multicentre study","authors":"Federica Sobrero , Fabio Roccia , Gian Battista Bottini , Maximilian Goetzinger , Euan Rae , Sean Laverick , Carlo Strada , Guglielmo Ramieri , Constantinus Politis , Kathia Dubron , Anamaria Sivrić , Mario Kordić , Sajjad Abdur Rahman , Tabishur Rahman , Valfrido Antonio Pereira-Filho , Luis Fernando de Oliveira Gorla , Timothy Aladelusi , Karpal Singh Sohal , Marko Lazíc , Vitomir S. Konstantinovic , Anže Birk","doi":"10.1016/j.jormas.2025.102607","DOIUrl":"10.1016/j.jormas.2025.102607","url":null,"abstract":"<div><h3>OBJECTIVE(S)</h3><div>Paediatric frontal fractures are uncommon injuries that may lead to significant complications. This study aimed to analyse patterns, surgical management, and outcomes of paediatric frontal sinus fractures in 14 maxillofacial centers worldwide.</div></div><div><h3>METHODS</h3><div>This multicentric retrospective study included patients ≤ 16 years of age operated for frontal fractures from January 2011 and December 2022. Collected data included: age, sex, cause of injury, site and type of fracture, surgical approach, nasofrontal outflow tract (NFOT) involvement, treatment, and outcome. Patients were divided based on the absence (group A) or presence (group B) of frontal sinus pneumatisation. Minimum follow-up was 6 months.</div></div><div><h3>RESULTS</h3><div>Thirty-two patients (mean age, 11.5 years) were included. Road traffic accidents were the main cause of injury (50%). In group A, 5/6 patients underwent open reduction and internal fixation (ORIF). In group B, 15 patients reported an isolated anterior table fracture, fixated with ORIF in 88% of cases. Nine patients reported combined anterior + posterior table fractures, 67% managed with anterior table fixation and cranialisation. One patient had an isolated posterior table fracture and underwent cranialisation. NFOT involvement was statistically associated with combined fractures (67%) (p=0.028) and managed with obliteration in 8/9 cases. Residual contour deformities of the frontal convexity were the most frequent complication (19%).</div></div><div><h3>CONCLUSION</h3><div>The surgical management varied by fracture site and sinus pneumatisation. Clinical outcomes were generally favourable, with residual contour deformities being the most common complications. Centers showed consistent approaches, but further multicenter studies are needed to establish definitive treatment strategies.</div></div><div><h3>Level of evidence</h3><div>3</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102607"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report a case of soft tissue sarcoma (STS) arising in the temporomandibular joint (TMJ), a rare site associated with considerable functional and aesthetic challenges when resection is required. A 33-year-old female with neurofibromatosis type 1 presented with progressive swelling in the right TMJ. Imaging revealed an enlarging, irregular region. Histopathological findings were suggestive of a high-grade STS, but definitive subclassification was not possible. The patient declined surgery due to potential facial nerve injury and cosmetic concerns. As an alternative, a combination of carbon ion radiotherapy and AI chemotherapy (ifosfamide and doxorubicin) was administered. At 5 years and 7 months post-treatment, the patient remains recurrence-free with preserved function and appearance. This case highlights the therapeutic potential of multidisciplinary, non-surgical strategies for head and neck STS when histologic ambiguity exists and radical surgery poses significant risk.
{"title":"Carbon ion radiotherapy and AI chemotherapy for soft tissue sarcoma of the temporomandibular joint: A case report of 5-year disease-free survival without wide resection","authors":"Masahito Hara , Kentaro Nomura , Misa Sumi , Naoki Katase , Kei-ichiro Miura , Tomohiro Yamada","doi":"10.1016/j.jormas.2025.102616","DOIUrl":"10.1016/j.jormas.2025.102616","url":null,"abstract":"<div><div>We report a case of soft tissue sarcoma (STS) arising in the temporomandibular joint (TMJ), a rare site associated with considerable functional and aesthetic challenges when resection is required. A 33-year-old female with neurofibromatosis type 1 presented with progressive swelling in the right TMJ. Imaging revealed an enlarging, irregular region. Histopathological findings were suggestive of a high-grade STS, but definitive subclassification was not possible. The patient declined surgery due to potential facial nerve injury and cosmetic concerns. As an alternative, a combination of carbon ion radiotherapy and AI chemotherapy (ifosfamide and doxorubicin) was administered. At 5 years and 7 months post-treatment, the patient remains recurrence-free with preserved function and appearance. This case highlights the therapeutic potential of multidisciplinary, non-surgical strategies for head and neck STS when histologic ambiguity exists and radical surgery poses significant risk.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102616"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-10-09DOI: 10.1016/j.jormas.2025.102603
Sameena Sandhu , Adib Al-Haj Husain , Victor Mergen , Tristan T. Demmert , Hatem Alkadhi , Thomas Flohr , Egon Burian , Bernd Stadlinger , Peter Kessler , Harald Essig , Maximilian Eberhard Hermann Wagner
Introduction
This ex vivo study aimed to compare photon-counting detector computed tomography (PCD-CT) and cone-beam computed tomography (CBCT) at matched standard- and low-dose radiation levels for evaluating perioperative imaging parameters relevant to mandibular fracture stabilization with osteosynthesis plates.
Material and Methods
Thirty-three osteosynthesis fixations were performed on six porcine mandibles with simulated fractures in the angle, body, and parasymphysis regions. Three types of plate systems (titanium microplates, titanium reconstruction plates, and bioresorbable copolymers) were used, each with varying plate thicknesses. Three blinded observers independently evaluated overall image quality, artifact severity, fracture line visibility, and visualization of peri‑osteosynthesis structures using 5-point visual analog scales. Descriptive statistics and inter-reader agreement (Krippendorff’s alpha) were calculated.
Results
PCD-CT consistently demonstrated superior overall image quality, reduced artifact severity, and better visualization of fracture lines and peri‑osteosynthetic structures compared to CBCT, particularly using low-dose settings. Bioresorbable plates caused no artifacts in either modality. Inter-observer agreement was good to excellent across all parameters (Krippendorff’s α = 0.72–1.0).
Conclusion
PCD-CT outperformed CBCT in visualizing mandibular fracture stabilization with various osteosynthesis materials, particularly under low-dose conditions, demonstrating high reliability among observers. These findings indicate that PCD-CT may offer diagnostic advantages in the perioperative setting; however, further clinical studies are needed to confirm its role in imaging oral and maxillofacial trauma.
{"title":"Comparative evaluation of photon-counting detector CT and cone-beam CT in the assessment of simulated mandibular trauma","authors":"Sameena Sandhu , Adib Al-Haj Husain , Victor Mergen , Tristan T. Demmert , Hatem Alkadhi , Thomas Flohr , Egon Burian , Bernd Stadlinger , Peter Kessler , Harald Essig , Maximilian Eberhard Hermann Wagner","doi":"10.1016/j.jormas.2025.102603","DOIUrl":"10.1016/j.jormas.2025.102603","url":null,"abstract":"<div><h3>Introduction</h3><div>This <em>ex vivo</em> study aimed to compare photon-counting detector computed tomography (PCD-CT) and cone-beam computed tomography (CBCT) at matched standard- and low-dose radiation levels for evaluating perioperative imaging parameters relevant to mandibular fracture stabilization with osteosynthesis plates.</div></div><div><h3>Material and Methods</h3><div>Thirty-three osteosynthesis fixations were performed on six porcine mandibles with simulated fractures in the angle, body, and parasymphysis regions. Three types of plate systems (titanium microplates, titanium reconstruction plates, and bioresorbable copolymers) were used, each with varying plate thicknesses. Three blinded observers independently evaluated overall image quality, artifact severity, fracture line visibility, and visualization of peri‑osteosynthesis structures using 5-point visual analog scales. Descriptive statistics and inter-reader agreement (Krippendorff’s alpha) were calculated.</div></div><div><h3>Results</h3><div>PCD-CT consistently demonstrated superior overall image quality, reduced artifact severity, and better visualization of fracture lines and peri‑osteosynthetic structures compared to CBCT, particularly using low-dose settings. Bioresorbable plates caused no artifacts in either modality. Inter-observer agreement was good to excellent across all parameters (Krippendorff’s α = 0.72–1.0).</div></div><div><h3>Conclusion</h3><div>PCD-CT outperformed CBCT in visualizing mandibular fracture stabilization with various osteosynthesis materials, particularly under low-dose conditions, demonstrating high reliability among observers. These findings indicate that PCD-CT may offer diagnostic advantages in the perioperative setting; however, further clinical studies are needed to confirm its role in imaging oral and maxillofacial trauma.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102603"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oral bone regeneration and associated complications: A systematic review and meta-analysis","authors":"Zoé Gaudimier , Samy Tawfik , Charles Kerouanton , Claudine Wulfman , Yohann Flottes","doi":"10.1016/j.jormas.2025.102606","DOIUrl":"10.1016/j.jormas.2025.102606","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102606"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-10-04DOI: 10.1016/j.jormas.2025.102596
Noémie Vanden Haute , Cyril Bouland , Morgan Lahon , Louis Brochet , Adélaïde Carlier , Andrea Varazzani , Pierre Bouletreau
Introduction
Thyroid-associated orbitopathy (TAO) is the most common adult inflammatory eye disease. Proptosis is a TAO common clinical sign. Besides daily physical discomfort, TAO impacts negatively mental health. Proptosis is treated by orbital decompression surgery. Infraorbital nerve dysesthesia is a common complication. Stereotactic navigation is an imaging-guided surgery. This less invasive procedure could reduce postoperative complications and improve recovery. This study aims to evaluate the impact of navigation on patients' outcomes.
Methods
A retrospective study was conducted, including TAO patients treated for unilateral or bilateral balanced orbital decompression between 2021 and 2024. One surgeon performed all the procedures. Pre, per and postoperative data such as lipectomy, surgery duration, proptosis, diplopia, symmetry of eyeball protrusion, infraorbital nerve injury with hypo or dysesthesia impacting daily life and subjective impact of the surgery on disfiguration were evaluated. Postoperative evaluation was conducted at least 6 months after the operation.
Results
The current study included 91 patients and 166 orbits, respectively, 135 in the classic surgery (Cs) group, 31 in the stereotactic surgery (Sts) group. The average time spent in the operating theatre in all surgery types was longer in the Sts approach. In both cases, the improvement in right-left symmetry was statistically significant (p < 0.001). Six months after surgery, 51 patients complained of hypo- or dysaesthesia (32.69 %). No significant differences were observed between the Sts or Cs approaches regarding first surgery or revision cases. No significant differences between the two groups were observed regarding the onset of new diplopia (p = 0.92).
{"title":"Balanced orbital decompression for thyroid-associated orbitopathy and the role of stereotactic navigation in infraorbital nerve preservation","authors":"Noémie Vanden Haute , Cyril Bouland , Morgan Lahon , Louis Brochet , Adélaïde Carlier , Andrea Varazzani , Pierre Bouletreau","doi":"10.1016/j.jormas.2025.102596","DOIUrl":"10.1016/j.jormas.2025.102596","url":null,"abstract":"<div><h3>Introduction</h3><div>Thyroid-associated orbitopathy (TAO) is the most common adult inflammatory eye disease. Proptosis is a TAO common clinical sign. Besides daily physical discomfort, TAO impacts negatively mental health. Proptosis is treated by orbital decompression surgery. Infraorbital nerve dysesthesia is a common complication. Stereotactic navigation is an imaging-guided surgery. This less invasive procedure could reduce postoperative complications and improve recovery. This study aims to evaluate the impact of navigation on patients' outcomes.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted, including TAO patients treated for unilateral or bilateral balanced orbital decompression between 2021 and 2024. One surgeon performed all the procedures. Pre, per and postoperative data such as lipectomy, surgery duration, proptosis, diplopia, symmetry of eyeball protrusion, infraorbital nerve injury with hypo or dysesthesia impacting daily life and subjective impact of the surgery on disfiguration were evaluated. Postoperative evaluation was conducted at least 6 months after the operation.</div></div><div><h3>Results</h3><div>The current study included 91 patients and 166 orbits, respectively, 135 in the classic surgery (Cs) group, 31 in the stereotactic surgery (Sts) group. The average time spent in the operating theatre in all surgery types was longer in the Sts approach. In both cases, the improvement in right-left symmetry was statistically significant (<em>p</em> < 0.001). Six months after surgery, 51 patients complained of hypo- or dysaesthesia (32.69 %). No significant differences were observed between the Sts or Cs approaches regarding first surgery or revision cases. No significant differences between the two groups were observed regarding the onset of new diplopia (<em>p</em> = 0.92).</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102596"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-10-16DOI: 10.1016/j.jormas.2025.102620
Poramate Pitak-Arnnop
{"title":"When authorship ethics falter: Lessons from South Korea and reflections for our journal and specialist community","authors":"Poramate Pitak-Arnnop","doi":"10.1016/j.jormas.2025.102620","DOIUrl":"10.1016/j.jormas.2025.102620","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102620"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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