Journal of Stomatology Oral and Maxillofacial Surgery最新文献_第8页

The efficacy of thyme honey mouth rinse on polypharmacy-induced xerostomia: A randomized controlled clinical trial with a biochemical assessment 百里香蜂蜜漱口水对多药性口干的疗效：一项随机对照临床试验及生化评估。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-11-04 DOI: 10.1016/j.jormas.2025.102641

Suzan S. Ibrahim , Neven Nabil Tadry , Ola M. Ezzatt , Radwa R. Hussein

Background

The global prevalence of systemic diseases and subsequent drug consumption, which is strongly associated with xerostomia, has become increasingly prominent. Considering the significance of maintaining good oral health and hypothesizing that natural salivary stimulants could serve as a safe and effective treatment option, we assessed the therapeutic efficiency of thyme honey mouthwash in treating individuals with polypharmacy-induced xerostomia.

Methods

A randomized controlled trial performed at Ain Shams University's Faculty of Dentistry, Egypt, on 64 patients consuming two or more xerostomia-inducing medications and complaining of dry mouth. Patients were randomly assigned to receive thyme honey oral rinse (Study Group) or normal saline oral rinse (Control Group) (3/day/4weeks). Unstimulated salivary flow rate (USFR), subjective (SDS), and clinical oral dryness scores (CODS) were evaluated at baseline and after 2 and 4 weeks. The salivary nitric oxide levels (SNO) and xerostomia-related quality of life scale (XeQoLS) were assessed at baseline and after 4 weeks.

Results

The USFR showed a notable increase (P < 0.001) in the study group (161.82 ± 89.57 %) compared to the control group (17.11 ± 10.53 %) after 4 weeks, accompanied by an improvement in oral dryness scores. XeQoLS values showed significant improvement, and the SNO levels significantly decreased after using thyme honey mouth rinse for 4 weeks.

Conclusion

The study concluded that the thyme honey mouth rinse effectively increased the salivary secretion, decreased SNO levels and oral dryness scores, and improved the quality of life for patients experiencing polypharmacy-induced xerostomia.

背景：与口干症密切相关的全身性疾病的全球流行和随后的药物消耗已变得越来越突出。考虑到保持良好口腔健康的重要性，并假设天然唾液兴奋剂可以作为一种安全有效的治疗选择，我们评估了百里香蜂蜜漱口水治疗多药性口干症的疗效。方法：在埃及艾因沙姆斯大学牙科学院进行了一项随机对照试验，对64名服用两种或两种以上引起口干的药物并抱怨口干的患者进行了试验。患者随机分为百里香蜂蜜漱口水组（研究组）和生理盐水漱口水组（对照组）（3次/天/4周）。在基线和2周和4周后评估非刺激唾液流率（USFR）、主观（SDS）和临床口腔干燥评分（CODS）。在基线和4周后评估唾液一氧化氮水平（SNO）和口干病相关生活质量量表（XeQoLS）。结果：4周后，研究组USFR（161.82±89.57%）较对照组（17.11±10.53%）显著升高（P < 0.001），同时口腔干燥评分也有所改善。使用百里香蜂蜜漱口水4周后，XeQoLS值显著改善，SNO水平显著降低。结论：百里香蜂蜜漱口水可有效提高多药性口干症患者的唾液分泌，降低SNO水平和口腔干燥评分，改善患者的生活质量。

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引用次数: 0

The role of photon-counting CT in next-generation craniofacial diagnostics 光子计数CT在新一代颅面诊断中的作用。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-11-04 DOI: 10.1016/j.jormas.2025.102642

Weihao Cheng

引用次数: 0

Botulinum toxin as a therapeutic adjunct in the management of facial fractures and osteotomies: case series and systematic review of an innovative chemical fixation approach 肉毒毒素作为面部骨折和截骨术的辅助治疗：一种创新的化学固定方法的病例系列和系统回顾。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-11-03 DOI: 10.1016/j.jormas.2025.102640

Jean-François Guignardat, Florent Barry, Sandrine Touzet-Roumazeille, Gwénaël Raoul, Joël Ferri, Romain Nicot

In the field of maxillofacial surgery, facial bone fractures and osteotomies are common but the management of these conditions is associated with complications, including displacement after fracture or relapse after orthognathic surgery. Botulinum toxin, a therapeutic agent that temporarily paralyzes the injected muscle, has several indications in the orofacial region. This study presents a case series and a systematic review of the literature regarding the use of botulinum toxin in masticatory muscles for the management of facial bone fractures and osteotomies. Three cases were reported and a systematic review was reported according to the PRISMA guidelines, focusing on the following research questions: “How does botulinum toxin affect bone displacement after osteotomy or fracture?”. The MEDLINE/PubMed, Web of Science, and Embase databases were searched using the following keywords: “botulinum toxin” AND [“fracture” OR “osteotomy” OR “bone healing”]. A total of 837 articles were initially identified. Based on the selection criteria, 8 studies were included. The review and case series showed that botulinum toxin could improve the fixation of facial bone fractures and osteotomies. Masticatory muscles generate significant tensile forces through their bony insertions. Intra-muscular botulinum toxin injections can be used to counteract this tension, thereby decreasing muscle function and improving surgical outcomes.

在颌面外科领域，面部骨折和截骨术是常见的，但这些情况的处理与并发症有关，包括骨折后移位或正颌手术后复发。肉毒杆菌毒素是一种治疗药物，可使注射的肌肉暂时麻痹，在口腔面部有几种适应症。本研究提出了一个病例系列和系统的文献综述关于使用肉毒杆菌毒素在咀嚼肌管理面部骨折和截骨术。本文报道了3例病例，并根据PRISMA指南进行了系统综述，重点研究了以下问题：“肉毒杆菌毒素如何影响截骨或骨折后的骨移位？”使用以下关键词搜索MEDLINE/PubMed， Web of Science和Embase数据库：“肉毒杆菌毒素”和[“骨折”或“截骨”或“骨愈合”]。初步确定共有837件物品。根据入选标准，共纳入8项研究。回顾和病例系列表明肉毒杆菌毒素可以改善面部骨折和截骨手术的固定。咀嚼肌通过其骨插入产生显著的张力。肌肉内注射肉毒杆菌毒素可以抵消这种张力，从而降低肌肉功能，改善手术效果。

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引用次数: 0

Epidemiology of dento-skeletal dysmorphoses in children treated for craniosynostosis in infancy 婴幼儿颅缝闭闭治疗儿童牙-骨骼畸形的流行病学。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-10-28 DOI: 10.1016/j.jormas.2025.102637

Edouard Lange , Julie Chauvel-Picard , Aqeel Lari A , Mohammad Khalaf , Ahmad Alali B , Arnaud Méon , Sanela Morand , Arnaud Gleizal

Background and objective

Craniosynostosis, defined as the premature fusion of one or more cranial sutures, leads to craniofacial deformities and may impair facial growth. Despite early surgical correction, the long-term impact on dento-skeletal development remains insufficiently characterized. This study evaluated the prevalence and determinants of dento-skeletal dysmorphoses (DSDs) in children who underwent craniosynostosis surgery during infancy and were followed until completion of growth.

Materials and methods

This ambispective study included 95 patients treated surgically for syndromic or nonsyndromic craniosynostosis at Lyon University Hospital between 2004 and 2006. Data were collected on craniosynostosis type, age at surgery, diagnosis and type of DSDs, treatment, and cranial base angle. Descriptive statistics and logistic regression analyses were used to assess prevalence, distribution and risk factors.

Results

Among the 95 children, 48 (50.5 %) developed a DSD. This patient had undergone craniosynostosis surgery at significantly older age (8.3 ± 2.9 vs 5.9 ± 2.4 months; Mann–Whitney test, p < 0.001). Trigonocephaly was strongly associated with maxillary transverse deficiency (OR = 4.84; 95 % CI [1.19–19.7]; p = 0.028), while scaphocephaly also showed a higher prevalence (21.1 %) without statistical significance. Scaphocephaly had the highest rate of Class II malocclusion (34.2 %), whereas brachycephaly and anterior plagiocephaly were mainly associated with Class III (100 % and 50 %, respectively). All syndromic cases developed Class III malocclusions.

Conclusion

Despite early cranial surgery, craniosynostosis remains associated with altered craniofacial growth and a high prevalence of malocclusions. Older age at surgy was an independent risk factor for DSDs. These findings underscore the importance of systematic, long-term orthodontic follow-up in both syndromic and nonsyndromic patients and suggest that an earlier surgical management may help reduce the risk of subsequent DSD.

背景和目的：颅缝闭合，定义为一个或多个颅缝的过早融合，导致颅面畸形，并可能损害面部生长。尽管早期手术矫正，对牙齿-骨骼发育的长期影响仍然没有充分的特征。本研究评估了在婴儿期接受颅缝闭锁手术的儿童中牙齿-骨骼畸形（dsd）的患病率和决定因素，并进行了随访，直到发育完成。材料和方法：这项双透视研究包括2004年至2006年在里昂大学医院接受手术治疗的95例综合征或非综合征性颅缝闭锁患者。收集颅缝闭合类型、手术年龄、诊断和dsd类型、治疗和颅底角的数据。描述性统计和逻辑回归分析用于评估患病率、分布和危险因素。结果：95例患儿中48例（50.5%）发生DSD。该患者接受颅缝闭锁手术的年龄明显较大（8.3±2.9 vs 5.9±2.4个月；Mann-Whitney检验，p < 0.001）。三角头畸形与上颌横突缺损有较强的相关性（OR = 4.84;95% CI [1.19-19.7]; p = 0.028），舟头畸形患病率较高（21.1%），但差异无统计学意义。II类错颌畸形发生率最高的是头形畸形（34.2%），III类错颌畸形以短头畸形和前斜头畸形为主（分别为100%和50%）。所有综合征病例均发展为III类错颌。结论：尽管早期颅脑手术，颅缝闭锁仍然与颅面生长改变和高发病率的错合有关。手术年龄较大是dsd的独立危险因素。这些发现强调了对综合征和非综合征患者进行系统、长期的正畸随访的重要性，并提示早期手术治疗可能有助于降低后续DSD的风险。

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引用次数: 0

Midfacial osteotomies for treatment of maxillo-zygomatic hypoplasia in class III malocclusion – A review of current techniques 面中截骨术治疗III类错颌颧发育不全的最新技术综述。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-10-28 DOI: 10.1016/j.jormas.2025.102638

Louis Brochet , Mathieu Daurade , Sanela Morand , Alexandra Delay , Pierre Bouletreau , Andrea Varazzani , Simon Rasteau

Maxillo-zygomatic hypoplasia can result in a specific clinical form of Class III malocclusion, characterized by insufficient projection and a flat, concave appearance of the midface. Conventional Le Fort I osteotomy is considered to be an effective treatment for occlusal function and facial aesthetics, since it increases upper lips, nasolabial and paranasal region, but with insufficient soft tissue projection over the maxillo-zygomatic region. Midfacial osteotomies have the advantage of treating severe maxillo-zygomatic hypoplasia and malocclusion simultaneously with good functional, aesthetics, and stable in long-term results. Incorporating advanced technologies enhances the precision and reproducibility of these osteotomies. A narrative review of the literature was conducted, focusing on various osteotomies for the correction of maxillo-zygomatic hypoplasia with Class III malocclusion, detailing their specific characteristics, surgical techniques, and clinical effect, complemented by a decision-making algorithm to guide treatment selection.

上颌-颧发育不全可导致III类错颌畸形的一种特殊临床形式，其特征是突出不足，中脸呈扁平凹状。Le Fort I型截骨术由于增加了上唇、鼻唇和鼻旁区域，但上颌颧区软组织投射不足，被认为是一种有效的治疗咬合功能和面部美观的方法。面中截骨术具有同时治疗严重颌颧发育不全和错颌畸形的优点，具有良好的功能性、美观性和远期疗效稳定。结合先进的技术提高了这些截骨术的精度和可重复性。对文献进行叙述性回顾，重点介绍各种截骨术矫正上颌颧发育不全合并III类错颌畸形的具体特点、手术技术和临床效果，并辅以决策算法指导治疗方案的选择。

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引用次数: 0

Oral carcinoma cuniculatum: Systematic review of a rare diagnostically challenging entity 口腔癌：一个罕见的诊断挑战性的实体的系统回顾。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-10-28 DOI: 10.1016/j.jormas.2025.102639

Tajindra Singh Saluja , Rashmi Maruti Hosalkar , Shalini Gupta , Sonam Khurana

Introduction

Oral Carcinoma Cuniculatum (OCC), an uncharted variant of oral squamous cell carcinoma (OSCC) is a slow growing tumor with varied clinical presentation, distinctive histopathological characteristics and generally favorable prognosis.

Materials and Methods

This systematic review was conducted as per the PRISMA guidelines. A comprehensive search was performed on PubMed and ScienceDirect database to extract cases of OCC reported until December 2023. A total of 68 cases were reviewed and the impact of different clinical parameters on the prognosis of OCC as well as common pitfalls in its diagnosis were identified.

Results

R software (version 4.4.2) was used to analyze the data. Cox regression analysis was carried out to assess the impact of clinical variables on survival outcome. Hazard ratio (HR) and 95 % confidence interval (CI) were calculated. Mean age at presentation was 58 years with a male predominance. Mandibular region was the most frequent site of occurrence. Enlargement of lymph nodes, tumor recurrence and metastasis were rare. Surgical management was the primary treatment modality. No significant association between clinical variables and survival was observed.

Conclusion

The unique clinicopathological characteristics and favorable prognosis of OCC distinguish it as a distinct clinical entity. Its indolent growth, non-aggressive clinical features, insufficient tissue sampling and limited awareness amongst clinicians are constant reasons contributing to delayed diagnosis and treatment.

口腔鳞状细胞癌（Oral Carcinoma cuuniculatum， OCC）是口腔鳞状细胞癌（Oral squamous cell Carcinoma， OSCC）的一种未知变异，是一种生长缓慢的肿瘤，具有多种临床表现、独特的组织病理学特征，通常预后良好。材料和方法：本系统综述按照PRISMA指南进行。对PubMed和ScienceDirect数据库进行全面检索，提取2023年12月之前报告的OCC病例。本文回顾了68例OCC患者的临床资料，分析了不同临床参数对OCC预后的影响及诊断中常见的误区。结果：采用R软件（4.4.2版）对数据进行分析。采用Cox回归分析评估临床变量对生存结局的影响。计算风险比（HR）和95%置信区间（CI）。平均发病年龄58岁，男性居多。下颌区是最常见的发生部位。淋巴结肿大，肿瘤复发和转移罕见。手术治疗是主要的治疗方式。临床变量和生存率之间没有明显的关联。结论：OCC独特的临床病理特征和良好的预后使其成为一种独特的临床实体。它的缓慢生长，非侵袭性临床特征，组织采样不足和临床医生的有限认识是导致诊断和治疗延迟的持续原因。

{"title":"Oral carcinoma cuniculatum: Systematic review of a rare diagnostically challenging entity","authors":"Tajindra Singh Saluja , Rashmi Maruti Hosalkar , Shalini Gupta , Sonam Khurana","doi":"10.1016/j.jormas.2025.102639","DOIUrl":"10.1016/j.jormas.2025.102639","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral Carcinoma Cuniculatum (OCC), an uncharted variant of oral squamous cell carcinoma (OSCC) is a slow growing tumor with varied clinical presentation, distinctive histopathological characteristics and generally favorable prognosis.</div></div><div><h3>Materials and Methods</h3><div>This systematic review was conducted as per the PRISMA guidelines. A comprehensive search was performed on PubMed and ScienceDirect database to extract cases of OCC reported until December 2023. A total of 68 cases were reviewed and the impact of different clinical parameters on the prognosis of OCC as well as common pitfalls in its diagnosis were identified.</div></div><div><h3>Results</h3><div>R software (version 4.4.2) was used to analyze the data. Cox regression analysis was carried out to assess the impact of clinical variables on survival outcome. Hazard ratio (HR) and 95 % confidence interval (CI) were calculated. Mean age at presentation was 58 years with a male predominance. Mandibular region was the most frequent site of occurrence. Enlargement of lymph nodes, tumor recurrence and metastasis were rare. Surgical management was the primary treatment modality. No significant association between clinical variables and survival was observed.</div></div><div><h3>Conclusion</h3><div>The unique clinicopathological characteristics and favorable prognosis of OCC distinguish it as a distinct clinical entity. Its indolent growth, non-aggressive clinical features, insufficient tissue sampling and limited awareness amongst clinicians are constant reasons contributing to delayed diagnosis and treatment.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 1","pages":"Article 102639"},"PeriodicalIF":2.0,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on “the oral and maxillofacial manifestations of stickler syndrome: A systematic review” 《Stickler综合征的口腔颌面表现：系统综述》述评。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-10-27 DOI: 10.1016/j.jormas.2025.102634

Rezhat Abbas, Aarushi Garg, Revathi Krishna

引用次数: 0

Apparent diffusion coefficient values of mandibular condyle bone marrow are associated with temporomandibular joint pain 下颌髁突骨髓表观扩散系数值与颞下颌关节疼痛有关

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-10-26 DOI: 10.1016/j.jormas.2025.102635

Hiroshi Yamamoto , Hirotaka Muraoka , Yukiko Iizuka , Eri Sawada , Takashi Kaneda , Hirotaka Oomine

Purpose

This study aimed to measure the association between apparent diffusion coefficient (ADC) and temporomandibular joint (TMJ) pain.

Materials and Methods

This retrospective study included patients with suspected TMJ disorders who underwent magnetic resonance imaging. Primary predictor variables included the ADC value. Other predictor variables included the presence of joint effusion (JE), disc displacement, and mandibular condyle deformity. The outcome variable was the presence or absence of TMJ pain. Data were analyzed using binomial logistic regression, with statistical significance set at P < 0.05.

Results

The participant comprised 93 patients with a mean age of 47.42 ± 16.17 years; 80.65 % were female. The mean ADC value of mandibular condylar bone marrow was 0.83 ± 0.16 (× 10^–3mm²/s ± SD) in the group with joint pain and 0.74 ± 0.18 (× 10^–3mm²/s ± SD) in the group without pain. A statistically significant association was observed between the ADC value and TMJ pain (odds ratio (OR) = 13.0; 95% confidence interval (CI) = 1.52, 110.94; P = 0.02). No significant associations were found between TMJ pain and JE (P = 0.26), articular disc displacement (P = 0.23) or deformities (P = 0.08). The cutoff value for predicting the presence or absence of pain was 1.23 × 10^–3 mm²/s.

Conclusions

This study demonstrated the efficacy of diffusion-weighted imaging (DWI) for TMJ pain assessment.

目的探讨表观扩散系数（ADC）与颞下颌关节（TMJ）疼痛的关系。材料与方法本回顾性研究纳入疑似颞下颌关节紊乱的患者并行磁共振成像。主要预测变量包括ADC值。其他预测变量包括关节积液（JE）、椎间盘移位和下颌髁畸形。结果变量为是否存在TMJ疼痛。资料分析采用二项logistic回归，P <； 0.05为统计学显著性。结果共纳入93例患者，平均年龄47.42±16.17岁；80.65%为女性。关节疼痛组下颌髁突骨髓平均ADC值为0.83±0.16 （× 10-3mm2 /s±SD），无疼痛组平均ADC值为0.74±0.18 （× 10-3mm2 /s±SD）。ADC值与颞下颌关节疼痛有统计学意义(比值比(OR) = 13.0；95%置信区间(CI) = 1.52, 110.94；P = 0.02)。颞下颌关节疼痛与乙脑（P = 0.26）、关节盘移位（P = 0.23）或畸形（P = 0.08）无显著相关性。预测疼痛存在与否的临界值为1.23 × 10-3 mm2/s。结论弥散加权成像（diffusion weighted imaging， DWI）在颞下颌关节疼痛评估中的应用价值。

{"title":"Apparent diffusion coefficient values of mandibular condyle bone marrow are associated with temporomandibular joint pain","authors":"Hiroshi Yamamoto , Hirotaka Muraoka , Yukiko Iizuka , Eri Sawada , Takashi Kaneda , Hirotaka Oomine","doi":"10.1016/j.jormas.2025.102635","DOIUrl":"10.1016/j.jormas.2025.102635","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to measure the association between apparent diffusion coefficient (ADC) and temporomandibular joint (TMJ) pain.</div></div><div><h3>Materials and Methods</h3><div>This retrospective study included patients with suspected TMJ disorders who underwent magnetic resonance imaging. Primary predictor variables included the ADC value. Other predictor variables included the presence of joint effusion (JE), disc displacement, and mandibular condyle deformity. The outcome variable was the presence or absence of TMJ pain. Data were analyzed using binomial logistic regression, with statistical significance set at <em>P</em> < 0.05.</div></div><div><h3>Results</h3><div>The participant comprised 93 patients with a mean age of 47.42 ± 16.17 years; 80.65 % were female. The mean ADC value of mandibular condylar bone marrow was 0.83 ± 0.16 (× 10<sup>–3</sup>mm<sup>2</sup>/<em>s</em> ± SD) in the group with joint pain and 0.74 ± 0.18 (× 10<sup>–3</sup>mm<sup>2</sup>/<em>s</em> ± SD) in the group without pain. A statistically significant association was observed between the ADC value and TMJ pain (odds ratio (OR) = 13.0; 95% confidence interval (CI) = 1.52, 110.94; <em>P</em> = 0.02). No significant associations were found between TMJ pain and JE (<em>P</em> = 0.26), articular disc displacement (<em>P</em> = 0.23) or deformities (<em>P</em> = 0.08). The cutoff value for predicting the presence or absence of pain was 1.23 × 10<sup>–3</sup> mm<sup>2</sup>/s.</div></div><div><h3>Conclusions</h3><div>This study demonstrated the efficacy of diffusion-weighted imaging (DWI) for TMJ pain assessment.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102635"},"PeriodicalIF":2.0,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145425197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BUB1 and CCNB2 mediate cell cycle and inflammation, influencing the progression of oral squamous cell carcinoma BUB1和CCNB2介导细胞周期和炎症，影响口腔鳞状细胞癌的进展。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-10-26 DOI: 10.1016/j.jormas.2025.102630

Wei Han , Sumei Wang , Haoyang Gao , Bowen Du

Aims

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. Although the molecular mechanisms of OSCC have been explored, they remain incompletely understood. This study aimed to comprehensively analyze key molecular pathways involved in the occurrence and progression of OSCC, with the goal of identifying novel biomarkers for early diagnosis and potential therapeutic targets to improve patient prognosis.

Methods

OSCC datasets (GSE31056 and GSE51010) were obtained from the Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) were identified and subjected to functional enrichment analysis, weighted gene co-expression network analysis (WGCNA), and protein-protein interaction (PPI) network analysis to predict core genes. Immune infiltration analysis was performed to estimate immune cell proportions. The Comparative Toxicogenomics Database (CTD) was used to identify diseases associated with the core genes. Real-time quantitative polymerase chain reaction (RT-qPCR) was conducted to validate the expression levels of core genes and related proteins.

Results

A total of 1017 DEGs were identified, which were mainly enriched in metabolic pathways, as well as the p53 and PPAR signaling pathways. Integration of three algorithms identified four central genes: BUB1, CCNB2, KIF23, and NEK2. Among them, BUB1 and CCNB2 were significantly overexpressed in OSCC compared with normal tissue samples. CTD analysis linked these genes to oral tumors, inflammation, and immune system diseases. Immune infiltration analysis revealed a higher proportion of neutrophils in OSCC samples. RT-qPCR confirmed elevated expression of BUB1, CCNB2, KIF23, NEK2, BAX, and Caspase-3 in OSCC.

Conclusion

Overexpression of BUB1 and CCNB2 may enhance cell cycle activity and inflammatory responses, thereby promoting OSCC cell proliferation.

目的：口腔鳞状细胞癌（OSCC）是口腔最常见的恶性肿瘤。虽然OSCC的分子机制已经被探索，但它们仍然不完全了解。本研究旨在全面分析参与OSCC发生发展的关键分子通路，寻找新的早期诊断生物标志物和潜在的治疗靶点，改善患者预后。方法：从Gene Expression Omnibus （GEO）获取OSCC数据集（GSE31056和GSE51010）。鉴定差异表达基因（deg），并进行功能富集分析、加权基因共表达网络分析（WGCNA）和蛋白-蛋白相互作用网络分析（PPI）预测核心基因。免疫浸润分析估计免疫细胞比例。比较毒物基因组学数据库（CTD）用于鉴定与核心基因相关的疾病。采用实时定量聚合酶链反应（RT-qPCR）验证核心基因及相关蛋白的表达水平。结果：共鉴定出1017个deg，主要富集于代谢途径，以及p53和PPAR信号通路。整合三种算法确定了四个中心基因：BUB1、CCNB2、KIF23和NEK2。其中，BUB1和CCNB2在OSCC中较正常组织明显过表达。CTD分析将这些基因与口腔肿瘤、炎症和免疫系统疾病联系起来。免疫浸润分析显示，OSCC样品中中性粒细胞比例较高。RT-qPCR证实在OSCC中BUB1、CCNB2、KIF23、NEK2、BAX和Caspase-3表达升高。结论：过表达BUB1和CCNB2可增强细胞周期活性和炎症反应，从而促进OSCC细胞增殖。

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引用次数: 0

Ectopic deciduous canine tooth inside the submandibular duct: A rare case report with literature review 下颌骨导管内乳牙异位1例并文献复习

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-10-25 DOI: 10.1016/j.jormas.2025.102636

Emad A. Magdy , Somaya N. Elkotamy , Omneya Gamaleldin , Mariam Aboayana , Aya A. Sakr

Obstructive sialadenitis is the most prevalent salivary gland disorder, with sialolithiasis, most commonly affecting the submandibular gland, being the leading cause. Rarely, other obstructive bodies can mimic sialoliths in clinical and radiographic presentations. This report presents a rare case of an ectopic tooth discovered accidentally within the submandibular duct. The tooth was successfully removed using a combined intraoral sialendoscopic approach, emphasizing the favorable outcome of such treatment option. Scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) analysis were performed to examine the tooth-like structure to identify its nature and justify presence in such an anatomical location. Findings revealed that the structure was not a sialolith, but rather a hypomineralized deciduous canine tooth, likely entrapped during embryologic development. This is a rare encounter that should be kept in mind while managing submandibular obstructive etiologies. A summary of related cases in literature is included to provide context for this rare presentation.

梗阻性涎腺炎是最常见的唾液腺疾病，涎石症最常影响下颌腺，是主要原因。很少有其他梗阻性体在临床和影像学表现上与涎石相似。本文报告一例罕见的异位牙意外发现于下颌下导管内。使用口腔内鼻内镜联合入路成功拔除牙齿，强调了这种治疗方案的良好结果。通过扫描电子显微镜（SEM）和能量色散x射线（EDX）分析来检查齿状结构，以确定其性质并证明其存在于该解剖位置。结果表明，该结构不是涎石，而是低矿化的乳牙，可能在胚胎发育过程中被夹住。这是一种罕见的遭遇，在处理下颌下阻塞性病因时应牢记在心。文献中相关案例的总结包括为这种罕见的表现提供背景。

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引用次数: 0