Journal of Stomatology Oral and Maxillofacial Surgery最新文献_第8页

Changes in resting saliva volume induced by transcutaneous electrical stimulation of the submandibular gland in adult Japanese women 经皮电刺激日本成年女性颌下腺诱导的静息唾液量的变化。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-10-08 DOI: 10.1016/j.jormas.2025.102617

Yoko Kobayashi-Mizumura , Miwa Matsuyama

Objective

To determine the resting saliva volume following transcutaneous electrical stimulation of the submandibular gland.

Methods

Thirty healthy women aged 20–64 years with no underlying diseases underwent 10 minutes of transcutaneous electrical stimulation (intervention) targeting the submandibular gland. Saliva volume at baseline, immediately post-intervention, and 10 min post-intervention were compared in three age groups, and also in two groups by baseline resting saliva volume. Subjective alterations in local and systemic symptoms were also evaluated via a questionnaire.

Results

The results showed no interaction between age and time factors, and no differences in changes in saliva volume according to age group. When the subjects were divided into two groups (low volume group [group L] and above-average volume group [group A]) according to their baseline resting saliva volume, group L showed a significant increase in saliva volume immediately post-intervention and maintained it for 10 min post-intervention. However, group A recorded no change in saliva volume immediately post-intervention, and saliva volume 10 min post-intervention was significantly lower than that immediately post-intervention. The significant difference in saliva volume between the two groups observed at baseline and immediately post-intervention was not observed 10 min post-intervention.

There were no subjective changes in local and systemic symptoms, including discomfort or fatigue, due to transcutaneous electrical stimulation. However, more than 70 % of subjects reported subjective improvement in dry mouth.

Conclusions

These results suggest that 10 min of transcutaneous electrical stimulation targeting the submandibular gland may have different effects depending on the subject's resting saliva volume.

目的：测定经皮电刺激颌下腺后静息唾液量。方法：30名健康女性，年龄20-64岁，无基础疾病，经皮经颅电刺激（干预）10分钟针对颌下腺。比较三个年龄组的基线、干预后立即和干预后10分钟的唾液量，并比较两组的基线静息唾液量。局部和全身症状的主观改变也通过问卷进行评估。结果：年龄和时间因素之间无交互作用，不同年龄组唾液量变化无差异。根据受试者的基线静息唾液量将其分为低容积组[L组]和高于平均容积组[A组]两组，L组在干预后立即出现明显的唾液量增加，并在干预后维持10分钟。然而，A组在干预后立即唾液量没有变化，干预后10分钟唾液量明显低于干预后立即唾液量。两组在基线和干预后立即观察到的唾液量的显著差异在干预后10分钟没有观察到。经皮电刺激没有引起局部和全身症状的主观变化，包括不适或疲劳。然而，超过70%的受试者报告说，口干的主观改善。结论：这些结果表明，针对颌下腺的10分钟经皮电刺激可能会根据受试者的静息唾液量产生不同的效果。

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引用次数: 0

The role of photon-counting CT in next-generation craniofacial diagnostics 光子计数CT在新一代颅面诊断中的作用。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-11-04 DOI: 10.1016/j.jormas.2025.102642

Weihao Cheng

引用次数: 0

Malignant transformation of a thyroglossal duct cyst located in the preepiglottic space: A case report and literature review 位于会厌前间隙的甲状舌管囊肿的恶性转化：1例报告及文献复习。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-10-09 DOI: 10.1016/j.jormas.2025.102611

Shucong Yao , Li Tian, Leitao Zhang

Objective

Thyroglossal duct cysts (TDC) are the most common tumors occurring in the midline and anterior neck regions and may affect swallowing function, infection, and even malignant transformation. The incidence of malignant transformation in thyroglossal duct cysts is very low, at approximately 1 %. Thyroglossal duct cysts extending into or occupying the pre-epiglottic space are extremely rare.

Case series presentation

A 37-year-old male developed papillary thyroid carcinoma originating from thyroglossal duct cysts that occupied the pre-epiglottic space. The tumor was successfully resected using a modified Sistrunk procedure. The relevant literature was reviewed.

Conclusion

Malignant transformation of thyroglossal duct cysts may occur at any site. Malignancy can be suggested by preoperative ultrasound and imaging examinations, thereby necessitating clinical vigilance.

目的：甲状舌管囊肿（TDC）是最常见的肿瘤，多发生于颈部中线和前颈部，可影响吞咽功能、感染，甚至恶性转化。甲状舌管囊肿恶性转化的发生率很低，约为1%。甲状舌管囊肿伸入或占据会厌前间隙是极为罕见的。病例系列报告：一名37岁男性因甲状腺舌管囊肿占据会厌前间隙而发展为甲状腺乳头状癌。使用改良的Sistrunk手术成功切除肿瘤。复习相关文献。结论：甲状舌管囊肿可在任何部位发生恶性转化。术前超声及影像学检查可提示恶性肿瘤，应提高临床警惕。

引用次数: 0

Rood & Shehab’s radiographic features associated with inferior alveolar nerve paraesthesia: A pooled analysis of 15,000 cases Rood & Shehab的放射学特征与下肺泡神经感觉异常相关：一项15000例病例的汇总分析。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-11-12 DOI: 10.1016/j.jormas.2025.102648

Jonas Hue

引用次数: 0

Can large language models perform clinical anamnesis? Comparative evaluation of ChatGPT, Claude, and Gemini in diagnostic reasoning through case-based questioning in oral and maxillofacial disorders 大型语言模型能进行临床记忆吗？chatgpt - 40、Claude和Gemini在口腔颌面疾病病例提问诊断推理中的比较评价。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-11-08 DOI: 10.1016/j.jormas.2025.102644

Birkan Eyup Yilmaz , Furkan Ozbey , Busra Nur Gokkurt Yilmaz , Hasan Akpinar

Introduction

This study aimed to evaluate whether large language models (LLMs) can emulate the clinical anamnesis process and diagnostic reasoning of oral and maxillofacial surgeons.

Materials and methods

Twenty-five real clinical cases from five diagnostic categories maxillary sinus diseases, periapical pathologies, orofacial pain disorders and neuropathic pain syndromes, odontogenic cysts and tumors, and temporomandibular joint disorders were simulated. Three LLMs (ChatGPT 4o, Claude 4, and Gemini 2.5) were each provided only the patient’s chief complaint and instructed to ask up to ten sequential questions to reach a diagnosis. One independent evaluators scored model performances on a 100 point scale, deducting 10 points for each additional question asked. Statistical comparisons were conducted using Kruskal–Wallis and Bonferroni post-hoc tests.

Results

No statistically significant difference was found among the models (p = 0.431). Gemini achieved the highest mean diagnostic score (43.6 ± 40.71), followed by ChatGPT-4o (37.2 ± 36.8) and Claude (31.6 ± 33.0). Diagnostic accuracy was highest in moderately difficult cases (p = 0.021) and markedly decreased in difficult ones (p = 0.016).

Conclusion

LLMs demonstrated the ability to perform structured anamnesis and reach clinically meaningful diagnostic conclusions using limited information. Although no significant difference was observed among the models, Gemini achieved the highest overall mean score. These findings indicate that LLMs hold potential as complementary tools for diagnostic reasoning and as simulation-based educational resources in oral and maxillofacial surgery.

前言：本研究旨在评估大型语言模型（LLMs）是否可以模拟口腔颌面外科医生的临床记忆过程和诊断推理。材料与方法：模拟上颌窦疾病、根尖周围病变、口面疼痛和神经性疼痛综合征、牙源性囊肿和肿瘤、颞下颌关节疾病5个诊断类别25例真实临床病例。三位法学硕士（ChatGPT 40， Claude 4和Gemini 2.5）每人只提供患者的主诉，并指示他们问多达10个连续的问题以得出诊断。一位独立评估师以100分制对模型的表现进行评分，每增加一个问题就扣除10分。采用Kruskal-Wallis和Bonferroni事后检验进行统计比较。结果：各模型间差异无统计学意义（p = 0.431）。Gemini的平均诊断评分最高（43.6±40.71），其次是chatgpt - 40（37.2±36.8）和Claude（31.6±33.0）。中困难病例诊断准确率最高（p = 0.021），困难病例诊断准确率显著降低（p = 0.016）。结论：大型语言模型显示了使用有限信息进行结构化记忆和得出有临床意义的诊断结论的能力。虽然在模型之间没有观察到显著差异，但双子座获得了最高的总体平均分。这些发现表明llm具有作为诊断推理的补充工具和作为口腔颌面外科模拟教育资源的潜力。

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引用次数: 0

Refractory oral manifestations of Crohn's disease 克罗恩病的难治性口腔表现

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-10-16 DOI: 10.1016/j.jormas.2025.102625

A. Khemis , R. Lan , F. Amatore , JM. Reimund , F. Campana , A. Falguière

Introduction

Persistent oral manifestations of Crohn's disease (CD), despite intestinal remission, remain a therapeutic challenge. This study aimed to describe two such cases and review available literature on management strategies.

Case reports

Despite infliximab and methotrexate, the first patient developed progressive oral lesions with only partial improvement under upadacitinib. The second achieved digestive remission under golimumab and successfully controlled oral lesions with intralesional corticosteroids.

Discussion

A literature review (Pubmed, ScienceDirect; up to January 2025) identified 17 articles involving 75 patients. Oral lesions appeared independently (54 %), concomitantly with digestive disease (20 %), or preceded it (26 %). Therapeutic responses were variable, with limited efficacy of anti-TNF antibodies, immunosuppressants, and corticosteroids. Anti-IL12/23 antibodies showed promising results in isolated cases, while data on anti-IL-23 antibodies and JAK inhibitors remain lacking.

Conclusion

Due to the absence of standardized therapeutic protocols, a personalized, multidisciplinary approach is essential. Further studies are needed to better define effective treatments.

克罗恩病（CD）的持续口腔表现，尽管肠道缓解，仍然是一个治疗挑战。本研究旨在描述两个这样的案例，并回顾有关管理策略的现有文献。病例报告：尽管使用英夫利昔单抗和甲氨蝶呤，第一位患者出现进行性口腔病变，在upadacitinib下只有部分改善。第二例患者在戈利姆单抗下获得消化缓解，并成功地使用皮质类固醇控制口腔病变。讨论：一篇文献综述（Pubmed, ScienceDirect；截至2025年1月）确定了17篇文章，涉及75名患者。口腔病变独立出现（54%），伴发消化系统疾病（20%），或先于口腔病变出现（26%）。治疗反应是可变的，抗肿瘤坏死因子抗体、免疫抑制剂和皮质类固醇的疗效有限。抗il - 12/23抗体在个别病例中显示出良好的结果，而抗il -23抗体和JAK抑制剂的数据仍然缺乏。结论：由于缺乏标准化的治疗方案，个性化，多学科的方法是必不可少的。需要进一步的研究来更好地确定有效的治疗方法。

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引用次数: 0

Non-surgical management of Ameloblastoma: A proof of concept study exploring the immunohistochemical expression of immune checkpoint Programmed Death Ligand- 1 in Ameloblastoma 成釉细胞瘤的非手术治疗：一项探讨免疫检查点程序性死亡配体- 1在成釉细胞瘤中免疫组织化学表达的概念验证研究。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-11-14 DOI: 10.1016/j.jormas.2025.102656

Revathi Krishna , Aadithya B. Urs , Jeyaseelan Augustine , Priya Kumar

Objectives

Ameloblastoma (AM) is the most common odontogenic tumour. Non-surgical and conservative treatment approaches are rising in popularity which traditionally involve segmental jaw resection with wide margins. The current study aims to assess the immunohistochemical expression of immune checkpoint Programmed death ligand – 1 (PDL-1) in AM when compared to normal dental follicle (DF).

Methods

Immunohistochemical staining of AM (n = 25) and DF (n = 12) using PDL-1 antibody was performed on tissue blocks retrieved retrospectively from the archives. The PDL-1 Total Positive Score (TPS), staining intensity score and H score were calculated. These were statistically compared and p value ≤ 0.05 was considered significant.

Results

We observed statistically significant increase in the expression of PDL-1 in AM (80 %) when compared to DF (58.4 %) in terms of TPS score (p < 0.001), H score (p = 0.022) and staining intensity (p < 0.001). PDL-1 positivity was seen in both peripheral and central odontogenic epithelial tumour cells with increased staining in the stellate reticulum like areas.

Conclusions

This study highlights the evidence of immune checkpoint alteration in AM which is a benign but aggressive odontogenic neoplasm. The preliminary results encourage more research in the terrain of immunotherapy for odontogenic neoplasms.

目的：成釉细胞瘤（AM）是最常见的牙源性肿瘤。非手术和保守治疗方法越来越受欢迎，传统的治疗方法包括宽边缘的节段性颌骨切除术。本研究旨在评估AM与正常牙滤泡（DF）中免疫检查点程序性死亡配体-1 （PDL-1）的免疫组织化学表达。方法：用PDL-1抗体对回顾性检索的组织块进行AM （n=25）和DF （n=12）的免疫组化染色。计算PDL-1总阳性评分（TPS）、染色强度评分和H评分。经统计学比较，p值≤0.05被认为是显著的。结果：在TPS评分方面，我们观察到AM中PDL-1的表达（80%）比DF（58.4%）有统计学意义上的增加(结论：本研究强调了AM中免疫检查点改变的证据，AM是一种良性但侵袭性的牙源性肿瘤。初步结果鼓励在牙源性肿瘤免疫治疗领域进行更多的研究。

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引用次数: 0

Effects of mandibular protrusion on the structural features of the masticatory muscles and upper airway space – a pilot study 下颌突出对咀嚼肌结构特征和上气道空间的影响-一项初步研究。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-10-06 DOI: 10.1016/j.jormas.2025.102598

Daria Madanchi , Catherine M. Paverd , Constantin von Deuster , Stefan Sommer , Marga B. Rominger , Dominik A. Ettlin , Luigi M. Gallo , Vera Colombo

Objectives

Obstructive Sleep Apnea (OSA) is the most common sleep breathing disorder. Treatment of mild to moderate OSA includes mandibular advancement devices (MAD). The varying degrees of mandibular protrusion induced by MADs affect the 3-dimensional arrangement of masticatory muscles. This pilot study aimed to observe the effects of different mandibular protrusions on masticatory muscle features and upper airways in one healthy participant.

Study Design

Anatomical and diffusion tensor imaging (DTI) magnetic resonance imaging (MRI) scans of the cephalic region of one 24-years-old healthy male subject were obtained with the mandible held stable by a personalized MAD in three positions: habitual bite position (P_R=0 mm), middle protrusion (P_MID=3.5 mm), maximum protrusion (P_MAX=7 mm). Streamline tractography (ST) based on Spherical Deconvolution (SD) was performed. Anatomical masks for the masseter (superficial/deep), medial and lateral pterygoid, and temporalis muscles were manually drawn. The angles formed by each detected muscle fiber projected on coronal, sagittal, and axial planes were computed, and their distribution was calculated. Furthermore, airway volume and minimum cross-sectional area (CSA_MIN) for each position were determined.

Results

ST method captured the fiber orientation of all masticatory muscles. Variations in muscle fiber angles and airway space were observed across mandibular positions. Both airway volume and CSA_MIN increased with increasing protrusion.

Conclusions

Mandibular protrusion affected the orientation and distribution of the masticatory muscle fibers and the upper airway space in the observed subject. These preliminary findings support further investigations into OSA patients.

目的：阻塞性睡眠呼吸暂停（OSA）是最常见的睡眠呼吸障碍。轻至中度OSA的治疗包括下颌推进装置（MAD）。MADs引起的不同程度的下颌突出影响咀嚼肌的三维排列。本初步研究旨在观察不同的下颌突起对一名健康受试者咀嚼肌肉特征和上呼吸道的影响。研究设计：选取1例24岁健康男性受试者，在习惯咬位（PR=0mm）、中突位（PMID=3.5mm）、最大突位（PMAX=7mm）三个位置，采用个性化MAD固定下颌骨，对其头部区域进行解剖和弥散张量成像（DTI）磁共振成像（MRI）扫描。采用基于球面反褶积（SD）的流线示踪成像（ST）。手动绘制咬肌（浅/深）、翼状内外侧肌和颞肌的解剖面具。计算每条检测到的肌纤维在冠状面、矢状面和轴向面上投影形成的角度，并计算其分布。此外，确定每个体位的气道容积和最小横截面积（CSAMIN）。结果：ST法捕获了所有咀嚼肌的纤维取向。在不同的下颌骨位置观察到肌纤维角度和气道容积的变化。气道容积和CSAMIN均随突出程度的增加而增加。结论：下颌前突影响了被试咀嚼肌纤维的定向、分布和上呼吸道空间。这些初步发现支持对阻塞性睡眠呼吸暂停患者的进一步调查。

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引用次数: 0

Impact of intraoperative hypotension on postoperative nausea and vomiting in patients undergoing orthognathic surgery 术中低血压对正颌手术患者术后恶心呕吐的影响。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-10-09 DOI: 10.1016/j.jormas.2025.102612

Sulin Tang, Rongrong Huang, Lili Guo, Liwei Jin, Yanli Zhang, Xia Zhang

Introduction

To evaluate the risk factors for postoperative nausea and vomiting (PONV) in patients undergoing orthognathic surgery, with particular emphasis on elucidating the potential relationship between PONV and the depth and duration of intraoperative hypotension (IOH).

Material and methods

We conducted a retrospective cohort study of patients who underwent orthognathic surgery between November 2022 and August 2024. Mean arterial pressure (MAP) was extracted from electronic medical records. Methods to evaluate IOH: 1. total area under curve (AUC); 2. time-weighted average (TWA) MAP; 3. cumulative time below absolute threshold values; 4. cumulative time in the lowest MAP categories. MAP thresholds were defined by absolute limits (≤ 65, ≤ 60, ≤ 55 mmHg).

Results

Of the 287 patients enrolled, five patients were excluded. At all absolute thresholds, patients experiencing PONV demonstrated significantly greater AUC and TWA than non-PONV patients (p < 0.05). Furthermore, at ≤ 60 and ≤ 55 mmHg threshold, PONV patients also exhibited significantly longer cumulative time of hypotensive (p < 0.05). When MAP is in 50–60 mmHg range for > 10 min (OR: 6.00, 95 % CI: 1.02–35.37), and when MAP is in ≤ 55 mmHg range for ≥ 5 min (OR: 0.42, 95 % CI: 0.20–0.90), were significantly associated with PONV (p < 0.05).

Conclusion

IOH may represent an additional important risk factor for PONV in patients undergoing orthognathic surgery, especially when MAP is in 50–60 mmHg range for > 10 min, or ≤ 55 mmHg range for ≥ 5 min.

前言：评估正颌手术患者术后恶心呕吐（PONV）的危险因素，特别强调阐明PONV与术中低血压（IOH）的深度和持续时间之间的潜在关系。材料和方法：我们对2022年11月至2024年8月期间接受正颌手术的患者进行了回顾性队列研究。从电子病历中提取平均动脉压（MAP）。评价IOH的方法：1。曲线下总面积；2. 时间加权平均（TWA） MAP；3. 累计时间低于绝对阈值；4. 最低MAP类别的累积时间。MAP阈值由绝对限值定义（≤65、≤60、≤55 mmHg）。结果：入组的287例患者中，有5例患者被排除。在所有绝对阈值下，PONV患者的AUC和TWA均显著高于非PONV患者（p < 0.05）。此外，在≤60和≤55 mmHg阈值时，PONV患者的累计降压时间也明显更长（p < 0.05）。当MAP在50-60 mmHg范围内持续bbb10分钟时（OR: 6.00, 95% CI: 1.02-35.37），当MAP在≤55 mmHg范围内持续≥5分钟时（OR: 0.42, 95% CI: 0.20-0.90），与PONV显著相关（p < 0.05）。结论：IOH可能是接受正颌手术患者PONV的另一个重要危险因素，特别是当MAP在50-60 mmHg范围内持续10分钟，或≤55 mmHg范围持续5分钟时。

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引用次数: 0

Effect of multidisciplinary ERAS-based nursing model on postoperative recovery in patients undergoing radical resection for oral cancer 多学科erass护理模式对口腔癌根治术后康复的影响。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2026-03-01 Epub Date: 2025-11-07 DOI: 10.1016/j.jormas.2025.102643

Xin Lin , Yi Wang , Yue Deng , Yan Mao , Yu Pu , Ying Chen

Objective

To evaluate the efficacy of multidisciplinary enhanced recovery after surgery (ERAS)-based nursing model in patients undergoing radical oral cancer resection and its impact on postoperative recovery.

Methods

A total of 288 patients undergoing radical oral cancer resection during December 2023-August 2025 were randomized to ERAS (n = 144) or control group (n = 144). Outcome measures included time to first feeding, length of hospital stay (LOS), complications, pain (Visual Analog Scale, VAS), inflammatory cytokines [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)], and quality of life (QoL) [36-Item Short Form Health Survey (SF-36), Functional Assessment of Cancer Therapy-General (FACT-G), Satisfaction With Life Scale (SWLS)]. Subgroup analyses were based on age, tumor stage, and preoperative nutrition.

Results

At day 7, RAS significantly reduced time to first feeding (17.93 ± 1.13 h vs. 26.56 ± 1.23 h) and LOS (8.35 ± 0.62 d vs. 12.18 ± 0.55 d; P < 0.001). ERAS also lowered VAS scores, IL-6, and TNF-α, while elevated SF-36, FACT-G, and SWLS scores (P < 0.001). Complications decreased in the ERAS group for infection (0.7 % vs. 27.8 %) and dysphagia (20.1 % vs. 67.4 %; P < 0.001). The ERAS group showed superior QoL trajectories and reduced adverse outcome risks (RR < 1, 95 % CI excluding 1). Subgroups with greatest benefit included age ≥ 60 years, malnutrition, and early-stage disease (interaction P < 0.05).

Conclusion

Multidisciplinary ERAS-based nursing accelerates recovery, reduces complications, and improves QoL post oral cancer surgery, with enhanced efficacy in elderly, malnourished, and early-stage patients.

目的：评价以ERAS为基础的多学科强化术后恢复护理模式在口腔癌根治性手术中的疗效及对术后恢复的影响。方法：将2023年12月~ 2025年8月行根治性口腔癌切除术的288例患者随机分为ERAS组（n = 144）和对照组（n = 144）。结果测量包括首次进食时间、住院时间（LOS）、并发症、疼痛（视觉模拟量表，VAS）、炎症因子[白细胞介素-6 （IL-6）、肿瘤坏死因子-α (TNF-α)]和生活质量（QoL）[36项简短健康调查（SF-36）、肿瘤治疗功能评估（FACT-G）、生活满意度量表（SWLS）]。亚组分析基于年龄、肿瘤分期和术前营养状况。结果：在第7天，RAS显著缩短了首次饲喂时间（17.93±1.13 h比26.56±1.23 h）和LOS（8.35±0.62 d比12.18±0.55 d, P < 0.001）。ERAS还降低了VAS评分、IL-6和TNF-α，同时升高了SF-36、FACT-G和SWLS评分（P < 0.001）。ERAS组感染（0.7% vs. 27.8%）和吞咽困难（20.1% vs. 67.4%; P < 0.001）并发症减少。ERAS组表现出更好的生活质量轨迹和更低的不良结局风险（RR < 1, 95% CI（排除1））。获益最大的亚组包括年龄≥60岁、营养不良和早期疾病（相互作用P < 0.05）。结论：多学科erass护理促进口腔癌术后康复，减少并发症，改善生活质量，对老年、营养不良、早期患者疗效显著。

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引用次数: 0