Journal of Stomatology Oral and Maxillofacial Surgery最新文献_第5页

Chatbot content analysis of patient information on orthodontic tooth extractions 聊天机器人内容分析正畸拔牙患者信息。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-12-08 DOI: 10.1016/j.jormas.2025.102675

Şule Gökmen , Ebru Yurdakurban , Kübra Gülnur Topsakal , Gökhan Serhat Duran

Introduction

This study aims to evaluate the quality, accuracy, readability, and understandability of patient information provided by various Artificial intelligence (AI)-based chatbots regarding orthodontic tooth extractions

Materials and methods

Two researchers created a list of questions for patients to ask the chatbots. The questions were categorized into ‘Pre-extraction’ and ‘Post-extraction’, with 20 questions in each category. Four different criteria were used to evaluate the chatbot responses to 40 questions: the Global Quality Scale (GQS), the Simple Measure of Gobbledygook (SMOG), and the Understandability and Accuracy Index. Jamovi (The Jamovi Project, 2022, version 2.3; Sydney, Australia) software was used for all statistical analyses.

Results

The highest mean values were observed in Claude 3.5 sonnet for GQS, Readability, and Accuracy Index. In terms of readability, as measured by the SMOG index, all three AI-based chatbots required a college-level education for comprehension. In the 'Pre-extraction' and 'Post-extraction' sections, Claude 3.5 Sonnet demonstrated the highest mean values for the GQS, readability, and accuracy indices. In terms of Understandability subcriteria 1 and 2, statistically significant differences were observed among the three chatbots, primarily due to the variation between Gemini and Claude 3.5 Sonnet.

Conclusion

AI-based chatbots with a variety of features have generally provided answers of high quality, reliability, and difficult readability to questions. Although the medical information related to orthodontic tooth extraction supplied by chatbots is of higher quality, it is recommended that individuals consult their healthcare professionals on this issue.

本研究旨在评估各种基于人工智能（AI）的聊天机器人提供的关于正畸拔牙的患者信息的质量、准确性、可读性和可理解性。材料和方法：两位研究人员创建了患者向聊天机器人提问的问题列表。这些问题被分为“提取前”和“提取后”，每个类别有20个问题。研究人员使用了四种不同的标准来评估聊天机器人对40个问题的回答：全球质量量表（GQS）、官样文章简单衡量量表（SMOG）以及可理解性和准确性指数。所有统计分析均使用Jamovi （The Jamovi Project, 2022, version 2.3; Sydney, Australia）软件。结果：Claude 3.5十四行诗GQS、可读性和准确性指数的平均值最高。在可读性方面，根据烟雾指数的衡量，这三个基于人工智能的聊天机器人都需要大学水平的教育才能理解。在“预提取”和“提取后”部分，Claude 3.5 Sonnet在GQS、可读性和准确性指标上显示出最高的平均值。在可理解性子标准1和2方面，三种聊天机器人之间存在统计学上的显著差异，主要是由于Gemini和Claude 3.5 Sonnet之间的差异。结论：基于人工智能的聊天机器人具有多种功能，通常能够提供高质量、可靠、难读的问题答案。虽然聊天机器人提供的与正畸拔牙相关的医疗信息质量更高，但建议个人在这个问题上咨询他们的医疗保健专业人员。

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引用次数: 0

The impact of heterodimeric G protein G12 family on proliferation, migration, and invasion in human oral squamous cell carcinoma cells 异二聚体G蛋白G12家族对人口腔鳞状细胞癌细胞增殖、迁移和侵袭的影响

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-12-06 DOI: 10.1016/j.jormas.2025.102679

Tao-li Fang, Xiao-xia Ma, Sen Yang, Xue-hua Ma, Jiang Xu

Objective

To characterize the expression of G12 subfamily members (GNA13 and GNA12) in oral squamous cell carcinoma (OSCC) and to evaluate their functional roles in regulating OSCC cell proliferation, migration and invasion.

Methods

Public bioinformatic resources were interrogated to profile GNA12 and GNA13 expression and associated functional pathways. Immunohistochemistry was performed on 102 OSCC and 48 adjacent non‑neoplastic tissue specimens, with correlation analyses against clinicopathological parameters and patient survival. Protein and transcript levels were validated in OSCC cell lines by Western blotting and RT‑qPCR. Loss‑of‑function studies using siRNA were followed by CCK‑8, colony formation, Transwell migration/invasion and wound‑healing assays to assess cellular phenotypes.

Results

Bioinformatic analyses showed significant upregulation of GNA13 and GNA12 in OSCC (P < 0.001) and enrichment of Rho-mediated signalling pathways. Immunohistochemistry confirmed increased GNA13 and GNA12 expression in tumour tissues compared with adjacent mucosa (P < 0.05). GNA13 expression correlated with tumour differentiation (P = 0.013) and nodal metastasis (P = 0.033), whereas GNA12 expression correlated with tumour differentiation (P = 0.010) and clinical stage (P = 0.027). Overexpression of both genes was associated with poorer overall survival (P < 0.001). Elevated expression in OSCC cell lines was validated by Western blot and RT-qPCR. Functional assays demonstrated that siRNA-mediated knockdown of GNA13 or GNA12 significantly reduced cell viability, colony formation, migration and invasion compared with controls (P < 0.05).

Conclusion

Elevated expressions of GNA13 and GNA12 in OSCC tumor tissues and cells are associated with poor patient prognosis. Targeted knockout of GNA13 and GNA12 effectively suppresses malignant behaviors of OSCC, including cell proliferation, migration abilities, and invasive potential. The G12 subfamily may represent a novel therapeutic target for OSCC treatment.

目的：研究G12亚家族成员GNA13和GNA12在口腔鳞癌（OSCC）中的表达特征，并探讨其在调节OSCC细胞增殖、迁移和侵袭中的功能作用。方法：利用公共生物信息学资源分析GNA12和GNA13的表达及其相关功能途径。对102例OSCC和48例相邻非肿瘤性组织标本进行免疫组化，并与临床病理参数和患者生存率进行相关性分析。通过Western blotting和RT - qPCR验证OSCC细胞系中的蛋白和转录物水平。使用siRNA进行功能丧失研究后，进行CCK - 8、菌落形成、Transwell迁移/侵袭和伤口愈合试验，以评估细胞表型。结果：生物信息学分析显示，GNA13和GNA12在OSCC中显著上调（P < 0.001）， rho介导的信号通路富集。免疫组化证实肿瘤组织中GNA13、GNA12的表达高于癌旁黏膜（P < 0.05）。GNA13表达与组织分级（P = 0.013）和淋巴结转移（P = 0.033）相关，而GNA12表达与肿瘤分化（P = 0.010）和临床/T分期（P = 0.027）相关。两种基因的过表达与较差的总生存率相关（P < 0.001）。Western blot和RT-qPCR验证了OSCC细胞株中表达升高。功能分析显示，与对照组相比，sirna介导的GNA13或GNA12的敲低显著降低了细胞活力、集落形成、迁移和侵袭（P < 0.05）。结论：GNA13、GNA12在OSCC肿瘤组织和细胞中的表达升高与患者预后不良有关。靶向敲除GNA13和GNA12可有效抑制OSCC的恶性行为，包括细胞增殖、迁移能力和侵袭潜能。G12亚家族可能是OSCC治疗的一个新的治疗靶点。

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引用次数: 0

The association between common NSAID use and early dental implant failure: A large-scale retrospective cohort study 常用非甾体抗炎药与早期种植体失败之间的关系：一项大规模回顾性队列研究。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-12-06 DOI: 10.1016/j.jormas.2025.102680

Georgios S. Chatzopoulos , Larry F. Wolff

Introduction

The impact of NSAIDs on osseointegration remains controversial, with conflicting evidence from animal models and human clinical trials. The aim of the study was to investigate the association between the use of common Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and the risk of early dental implant failure in a large, real-world patient cohort.

Methods

This retrospective cohort study utilized an EHR database of 12,943 patients receiving 49,997 implants. Patients were divided into an NSAID group (n = 3133) and a non-NSAID control group (n = 9810). The primary outcome was early implant failure, defined as implant removal within six months of placement. Multivariable logistic regression models were used to calculate Odds Ratios (ORs) for failure, adjusting for patient age, gender, history of diabetes, and history of osteoporosis. Analyses were conducted at both the implant and patient levels.

Results

Patients in the NSAID group were significantly older (62.8 vs. 58.7 years, p < 0.0001) and had a higher prevalence of diabetes (22.0% vs. 16.7 %, p < 0.0001) and osteoporosis (11.0 % vs. 7.0 %, p < 0.0001). After adjusting for confounders, implant-level analysis showed that Ibuprofen use (OR 2.29; 95 % CI 1.48–3.55; p < 0.0001) and Naproxen use (OR 2.65; 95 % CI 1.22–5.75; p = 0.0137) were significantly associated with increased odds of early failure. At the patient level, the association remained highly significant for Ibuprofen (OR 2.87; 95 % CI 1.83–4.51; p < 0.0001), but not for Naproxen (p = 0.0689).

Conclusion

The use of Ibuprofen and, to a lesser extent, Naproxen, is associated with a significantly increased risk of early dental implant failure, independent of other patient risk factors. Clinicians should consider these findings when formulating post-operative analgesic plans, particularly for patients with complex medical histories.

非甾体抗炎药对骨整合的影响仍然存在争议，动物模型和人体临床试验的证据相互矛盾。该研究的目的是在一个庞大的现实世界患者队列中调查常用非甾体抗炎药（NSAIDs）的使用与早期种植体失败风险之间的关系。方法：本回顾性队列研究利用了12943例植入物患者的EHR数据库。患者被分为非甾体抗炎药组（n= 3133）和非甾体抗炎药对照组（n= 9810）。主要结局是早期种植体失败，定义为种植体在放置6个月内移除。使用多变量logistic回归模型计算失败的优势比（ORs），调整患者的年龄、性别、糖尿病史和骨质疏松史。在种植体和患者水平上进行分析。结果：非甾体抗炎药组患者的年龄明显增加（62.8岁vs. 58.7岁）。结论：使用布洛芬和（在较小程度上）使用萘普生与早期种植体失败的风险显著增加相关，独立于其他患者危险因素。临床医生在制定术后镇痛计划时应考虑这些发现，特别是对于有复杂病史的患者。

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引用次数: 0

Oral and maxillofacial schwannoma (OMSCH): An institutional study of 102 patients 口腔颌面神经鞘瘤（OMSCH）： 102例患者的机构研究。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-12-05 DOI: 10.1016/j.jormas.2025.102678

Lingli Huang , Wenya Zhu , Qicheng Ye , Shengwen Liu , Hao Lu , Wenjun Yang , Wanlin Xu

Background

Oral and maxillofacial schwannoma (OMSCH) is a benign tumor originating from the Schwann cells of peripheral nerves in the oral and maxillofacial region, whose diagnosis and treatment remain challenging.

Methods

This retrospective study analyzed OMSCH cases treated at our institution from January 2020 to June 2022. Demographics, clinical features, diagnostic methods, surgical approaches, and postoperative pathology were comprehensively evaluated.

Results

A total of 102 patients with OMSCH were included, ranging from 8 to 86 years, with a notable female predominance. The parotid gland was the most frequent site of involvement, while tongue was the most commonly affected structure within the oral cavity. Seventy-one patients (69.6 %) had tumors exceeding 2 cm in size. Magnetic resonance imaging (MRI) exhibited the highest diagnostic accuracy (20/46, 43.5 %). Eighty-five patients (83.3 %) underwent complete surgical resection, with intracapsular enucleation primarily employed for facial nerve schwannomas. Postoperative histopathology revealed a characteristic biphasic pattern and prominent S100/SOX10 immunohistochemical staining. Postoperative complications included tongue deviation in one patient and facial paralysis in 17 patients (16.7 %). No recurrences were observed during follow-up (30–69 months).

Conclusion

OMSCH is a rare tumor with limited diagnostic accuracy. MRI remains the preferred diagnostic modality, and surgical intervention generally results in favorable outcomes.

背景：口腔颌面部神经鞘瘤（OMSCH）是一种起源于口腔颌面部周围神经雪旺细胞的良性肿瘤，其诊断和治疗仍然具有挑战性。方法：回顾性分析2020年1月至2022年6月在我院治疗的OMSCH病例。对人口统计学、临床特征、诊断方法、手术入路及术后病理进行综合评价。结果：共纳入OMSCH患者102例，年龄8 ~ 86岁，以女性为主。腮腺是最常见的受累部位，而舌头是口腔内最常见的受累结构。71例（69.6%）患者肿瘤大小超过2cm。磁共振成像（MRI）的诊断准确率最高（20/46,43.5%）。85例患者（83.3%）接受了完整的手术切除，囊内去核主要用于面神经鞘瘤。术后组织病理学显示特征性双相模式和显著的S100/SOX10免疫组化染色。术后并发症包括舌偏1例，面瘫17例（16.7%）。随访30 ~ 69个月无复发。结论：OMSCH是一种罕见的肿瘤，诊断准确性有限。MRI仍然是首选的诊断方式，手术干预通常会产生良好的结果。

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引用次数: 0

CEACAM1 regulates autophagy in oral squamous cell carcinoma through the PPAR signaling pathway CEACAM1通过PPAR信号通路调控口腔鳞状细胞癌的自噬。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-12-05 DOI: 10.1016/j.jormas.2025.102676

Sai Ma, Zhonghua Wang, Chao Li, Zhenli Liu, Xuan Zhang

Background

Oral squamous cell carcinoma (OSCC), as one of the most common malignant tumors in the head and neck region, has a complex and diverse pathogenesis. An increasing number of studies indicate that cellular autophagy plays a significant role in the occurrence, development, and treatment of tumors. However, the specific mechanisms of autophagy in oral squamous cell carcinoma are not yet fully understood.

Methods

This study is based on the oral squamous cell carcinoma dataset GSE222673, and has conducted a gene set enrichment analysis (GSEA) on the whole genome, aiming to find potential enriched pathways among non-differentially expressed genes. Weighted gene co-expression network analysis (WGCNA) was used to identify key modules and determine the key hub genes within the modules. The experimental part employed Western Blot to verify the expression changes and functional roles of core molecules in OSCC cells.

Results

GSEA indicates that non-differentially expressed genes are enriched in mitochondrial autophagy, PPAR, Toll-like receptor, and MTOR signaling pathways. WGCNA identified 3794 hub genes, including the CEACAM1 gene. Further Western Blot experiments indicate that in OSCC cells, the CEACAM1 gene has a negative regulatory effect on the PPAR signaling pathway, and changes in its expression levels affect the upregulation or downregulation of key molecules PPAR, ILK, and PDK1. Furthermore, the overexpression of the CEACAM1 gene can promote the expression of autophagy-related molecules such as PINK1, Parkin, LC3I, LC3II, and mitochondrial fusion-related proteins OPA1, MFN2, as well as mitochondrial biogenesis-related proteins NRF1, TFAM in OSCC cells. The overexpression of the CEACAM1 gene inhibits the expression of mitochondrial fission-related proteins and promotes the expression of apoptosis-related proteins.

Conclusions

CEACAM1 regulates the PPAR signaling pathway key molecules, affecting OSCC cell autophagy, mitochondrial balance, and apoptosis.

背景：口腔鳞状细胞癌（Oral squamous cell carcinoma， OSCC）是头颈部最常见的恶性肿瘤之一，其发病机制复杂多样。越来越多的研究表明，细胞自噬在肿瘤的发生、发展和治疗中起着重要的作用。然而，自噬在口腔鳞状细胞癌中的具体机制尚不完全清楚。方法：本研究基于口腔鳞状细胞癌数据集GSE222673，对全基因组进行基因集富集分析（GSEA），旨在寻找非差异表达基因中潜在的富集途径。加权基因共表达网络分析（WGCNA）用于识别关键模块，并确定模块内的关键枢纽基因。实验部分采用Western Blot验证核心分子在OSCC细胞中的表达变化及功能作用。结果：GSEA显示非差异表达基因在线粒体自噬、PPAR、toll样受体和MTOR信号通路中富集。WGCNA鉴定出3794个枢纽基因，包括CEACAM1基因。进一步的Western Blot实验表明，在OSCC细胞中，CEACAM1基因对PPAR信号通路具有负调控作用，其表达水平的变化影响关键分子PPAR、ILK和PDK1的上调或下调。此外，CEACAM1基因的过表达可以促进自噬相关分子如PINK1、Parkin、LC3I、LC3II，以及线粒体融合相关蛋白OPA1、MFN2，以及线粒体生物发生相关蛋白NRF1、TFAM的表达。CEACAM1基因的过表达抑制线粒体分裂相关蛋白的表达，促进凋亡相关蛋白的表达。结论：CEACAM1调控PPAR信号通路关键分子，影响OSCC细胞自噬、线粒体平衡和凋亡。

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引用次数: 0

Nasal irrigation reduces radiation-induced rhinosinusitis in nasopharyngeal carcinoma treated with volumetric modulated arc therapy 鼻腔冲洗减少鼻咽癌放射诱导的鼻窦炎与体积调节弧线治疗。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-12-05 DOI: 10.1016/j.jormas.2025.102677

Jiarong Li , Yanchen Ji , Zhining Yang , Baihan Lin , Ying Zhang , Renxian Xie

Background

Nasopharyngeal carcinoma (NPC), prevalent in Southeast Asia and Southern China, is commonly treated with radiotherapy (RT). Volumetric modulated arc therapy (VMAT) improves tumor control but radiation-induced rhinosinusitis (RIRS) remains a major complication. Nasal irrigation shows potential in mitigating mucosal damage, yet evidence in VMAT-treated NPC patients is limited. This study evaluates Nasal irrigation’s efficacy in reducing RIRS incidence in this population.

Methods

A retrospective cohort of 195 NPC patients treated with VMAT (2018–2021) was analyzed. Patients were divided into Nasal irrigation (n = 84) and non-Nasal irrigation (n = 111) groups. Baseline characteristics and dosimetric parameters (V20–V70, Dmean, Dmax) of the maxillary sinus were compared. Kaplan-Meier analysis and Cox regression models assessed Nasal irrigation’s impact on RIRS risk, with subgroup analyses stratified by sex, TNM stage, and treatment regimen.

Results

Kaplan-Meier analysis showed that the probability of developing RIRS was significantly higher in the group that did not undergo nasal irrigation compared with the NI group (p < 0.001). Multivariate analysis confirmed NI reduced RIRS risk (adjusted HR=0.26, p < 0.001), while allergic rhinitis increased risk (adjusted HR=6.56, p = 0.009). For maxillary sinusitis, NI remained protective (HR=0.29, p < 0.001), and higher V70 dose (≥70 Gy) correlated with elevated risk (HR=1.10, p = 0.007). Subgroup analyses demonstrated consistent benefits across sex, T/N stage, and treatment groups (all interaction p > 0.05).

Conclusion

NI reduces radiation-induced rhinosinusitis risk in VMAT-treated NPC patients, independent of baseline characteristics. Allergic rhinitis and high V70 doses independently worsen outcomes. These findings support NI as a simple, effective adjunct to improve post-radiotherapy quality of life.

背景：鼻咽癌（NPC）常见于东南亚和中国南部，通常采用放疗（RT）治疗。体积调节弧线治疗（VMAT）改善肿瘤控制，但放射性鼻窦炎（RIRS）仍然是主要并发症。鼻冲洗显示出减轻粘膜损伤的潜力，但在vmat治疗的鼻咽癌患者中的证据有限。本研究评估鼻腔冲洗在降低该人群中RIRS发病率方面的疗效。方法：回顾性分析195例接受VMAT治疗的鼻咽癌患者（2018-2021）。患者分为鼻冲洗组（84例）和非鼻冲洗组（111例）。比较上颌窦的基线特征和剂量学参数（V20-V70、Dmean、Dmax）。Kaplan-Meier分析和Cox回归模型评估了鼻腔冲洗对RIRS风险的影响，并按性别、TNM分期和治疗方案进行了亚组分析。结果：Kaplan-Meier分析显示，未进行鼻冲洗组发生RIRS的概率明显高于NI组（p < 0.001）。多因素分析证实，NI降低了RIRS风险（调整HR=0.26, p < 0.001），而变应性鼻炎增加了RIRS风险（调整HR=6.56, p =0.009）。对于上颌鼻窦炎，NI仍然具有保护作用（HR=0.29, p < 0.001），较高的V70剂量（≥70 Gy）与风险升高相关（HR=1.10, p =0.007）。亚组分析显示，跨性别、T/N分期和治疗组均有一致的益处（所有相互作用p < 0.05）。结论：NI降低了vmat治疗的鼻咽癌患者放射性鼻窦炎的风险，与基线特征无关。变应性鼻炎和高剂量V70单独加重预后。这些发现支持NI作为一种简单、有效的辅助手段来改善放疗后的生活质量。

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引用次数: 0

The causal link between socioeconomic status and oral cancer risk: Evidence from Mendelian Randomization and global burden of disease analysis (1990–2021) 社会经济地位与口腔癌风险之间的因果关系：来自孟德尔随机化和全球疾病负担分析的证据（1990-2021）。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-12-02 DOI: 10.1016/j.jormas.2025.102673

Shiqi Li, Jinwei Wang, Xiaoshuai Wei, Zheng Liang

Objective

Oral cancer shows significant disparities across economic levels and genders. We examine trends and determinants of oral cancer burden in regions with varying Social Development Index (SDI) levels using epidemiological data and Mendelian Randomization (MR).

Methods

Data from the 2021 Global Burden of Disease (GBD) dataset were analyzed across various SDI regions. Temporal trends were assessed using annual percentage change (EAPC), and risk factor attribution, decomposition analyses, and age-period-cohort models were conducted. MR were used to examine the causal relationship between economic factors and oral cancer incidence.

Results

Oral cancer burden is higher in males. High SDI regions have lower incidence, mortality, and DALYs compared to low SDI regions, with later onset and more pronounced gender differences. Tobacco and alcohol use are major risk factors in high SDI regions, while chewing tobacco predominates in low SDI areas. In low-SDI regions, population growth increases the risk; aging boosts incidence in high-SDI areas. MR analysis showed a negative causal relationship between educational attainment, household income, and oral cancer risk (P < 0.05).

Conclusion

Improving socioeconomic factors, particularly education and income, may help prevent oral cancer. The burden is higher in low-SDI regions, among males, and among older people, indicating a need for targeted prevention.

目的：口腔癌在经济水平和性别之间存在显著差异。我们使用流行病学数据和孟德尔随机化（MR）研究了不同社会发展指数（SDI）水平地区口腔癌负担的趋势和决定因素。方法：分析来自2021年全球疾病负担（GBD）数据集的各个SDI区域的数据。采用年百分比变化（EAPC）评估时间趋势，并进行风险因素归因和分解分析。使用年龄-时期-队列模型和MR来检验经济因素与口腔癌发病率之间的因果关系。结果：男性口腔癌负担较高。与低SDI地区相比，高SDI地区的发病率、死亡率和DALYs更低，发病时间更晚，性别差异更明显。烟草和酒精使用是高SDI地区的主要危险因素，而咀嚼烟草在低SDI地区占主导地位。在低sdi地区，人口变化增加了风险；年龄增加了高sdi地区的发病率。磁共振分析显示受教育程度、家庭收入和口腔癌风险之间存在负相关关系(结论：改善社会经济因素，特别是教育和收入，可能有助于预防口腔癌。低sdi地区、男性和老年人的负担更高，这表明需要进行有针对性的预防。

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引用次数: 0

Finite element analysis of transnasal, zygomatic and pterygoid implants in the rehabilitation of the atrophic maxilla 经鼻颧翼状假体修复萎缩上颌的有限元分析。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-12-02 DOI: 10.1016/j.jormas.2025.102674

Eren Togac, Ferhat Ayranci, Oguzhan Tapci

Aim

This study aimed to evaluate the stress distribution generated by transnasal, zygomatic, and pterygoid implants on the implants and surrounding bone in atrophic maxilla models using finite element stress analysis

Materials and methods

Three atrophic maxilla models were designed. Model 1 included transnasal implants in regions 12 and 22 and zygomatic implants in regions 15 and 25. Model 2 consisted of four zygomatic implants in regions 12, 15, 22, and 25. Model 3 included transnasal implants in regions 12 and 22, zygomatic implants in regions 15 and 25, and pterygoid implants in regions 17 and 27. A vertical load of 150 N was applied separately to teeth 11 and 16 via a spherical food bolus model

Results

The highest Von Mises stress values on implants under both anterior and posterior loading were recorded in Model 1, whereas the lowest values were found in Model 3. For abutments, Model 2 exhibited the highest stress values, while Model 3 showed the lowest. In cortical bone, the highest stress values were observed in Model 2, whereas cancellous bone exhibited the highest stresses in Model 1. The lowest stress values in both bone types were consistently seen in Model 3

Conclusion

The combination of transnasal and zygomatic implants may serve as an alternative to the quad zygoma concept. However, incorporating pterygoid implants further reduces stress values and may provide biomechanical advantages in the rehabilitation of the atrophic maxilla.

目的：采用有限元应力分析方法评估经鼻、颧、翼状种植体对萎缩上颌模型种植体及周围骨产生的应力分布。模型1包括12区和22区经鼻植入物和15区和25区颧植入物。模型2由4个颧植入体组成，分别位于12、15、22和25区。模型3包括12区和22区经鼻假体，15区和25区颧假体，17区和27区翼状假体。结果：种植体在前、后两种载荷下的Von Mises应力值均在模型1中最高，在模型3中最低。对于基台，模型2的应力值最高，模型3的应力值最低。在皮质骨中，模型2中观察到的应力值最高，而松质骨在模型1中观察到的应力值最高。结论：经鼻颧骨联合植入可以作为四颧骨概念的替代方案。然而，合并翼状骨植入物进一步降低应力值，并可能在萎缩上颌的康复中提供生物力学优势。

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引用次数: 0

Deep neck infections caused by foreign bodies: Literature review 异物引起的深颈部感染：文献综述

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-11-27 DOI: 10.1016/j.jormas.2025.102669

Hiroki Kimura , Eiji Iwata , Joe Iwanaga , Chizuru Kobayashi , Yuki Kunisada , Norie Yoshioka , Akira Tachibana , Masaya Akashi , Soichiro Ibaragi

Background

Deep neck infections (DNIs) are potentially life-threatening diseases that are mainly caused by odontogenic and peritonsillar infections. Although DNI has also been reported to be caused by foreign bodies, no review articles exist to date.

Methods

A comprehensive literature search was conducted using PubMed for articles published between 2005 and 2025.

Results

A total of 131 relevant articles were identified. Frequently reported foreign bodies included injectable materials used in facial filler and fish bone. The latency to symptom onset varied widely, ranging from within 1 h after foreign body insertion to as long as 25 years, with substantial differences observed depending on the type of foreign body.

Conclusion

Although foreign bodies are rare causes of DNIs, various type of foreign bodies have been reported. Recognizing the possibilities of DNIs caused by foreign bodies will help oral and maxillofacial surgeons to search for the cause rapidly and determine treatment plans and prevent recurrence.

深颈部感染（DNIs）是一种潜在的危及生命的疾病，主要由牙源性和牙周感染引起。尽管也有报道称DNI是由外国机构引起的，但迄今为止尚无评论文章。方法利用PubMed对2005 ~ 2025年间发表的文献进行综合检索。结果共鉴定出相关文献131篇。经常报道的异物包括用于面部填充物和鱼骨的注射材料。症状发作的潜伏期差异很大，从异物插入后1小时到长达25年不等，根据异物的类型有很大差异。结论虽然异物是引起DNIs的罕见原因，但各种类型的异物均有报道。认识到由异物引起的DNIs的可能性将有助于口腔颌面外科医生迅速寻找病因，确定治疗方案并防止复发。

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引用次数: 0

Disparity in operation decision in Maxillofacial surgery: Influence of gender and social status 颌面外科手术决策的差异：性别和社会地位的影响。

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2025-11-27 DOI: 10.1016/j.jormas.2025.102672

Laure Franchomme, Aurore Loretti, Romain Nicot

引用次数: 0