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Evaluation of social appearance concerns and satisfaction after orthognathic surgery 对正颌外科手术后社会外观关注度和满意度的评估。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101934

The main aim of orthognathic surgery is to provide a good occlusion and masticatory function and to achieve positive changes in facial aesthetics. The aim of this study was to determine the reasons behind patients' acceptance of orthognathic surgery and their expectations from this treatment, to assess whether their expectations were met, the change in their self-confidence and their satisfaction, and finally, to use the results obtained to inform future surgical procedures to increase patient satisfaction. The study was designed as a cross-sectional observational study and included 73 people treated with orthognathic surgery (surgery group) and 42 people with minimal crowding who did not require treatment (control group). The study found that the primary reason for requesting orthognathic surgery was to improve facial appearance and that patients had high expectations in this regard. Using the Social Appearance Anxiety Questionnaire and the Expectation and Satisfaction Questionnaire, 73.97 % of patients in our study said the treatment met their expectations and 90.41 % said they were satisfied with the overall results of the surgery. The study also highlighted the importance of surgeon-patient communication and the satisfaction of the patient's environment with the final result in determining patient satisfaction. In conclusion, since patients' high expectations of orthognathic surgery influence treatment success and patient satisfaction, it is important to know and manage patients' expectations before treatment and to have good patient-surgeon communication to increase patient satisfaction after surgery.

正颌外科手术的主要目的是提供良好的咬合和咀嚼功能,并实现面部美学的积极改变。本研究的目的是确定患者接受正颌外科手术的原因以及他们对这种治疗的期望,评估他们的期望是否得到满足、自信心的变化以及满意度,最后利用获得的结果为今后的外科手术提供参考,以提高患者的满意度。研究设计为横断面观察研究,包括 73 名接受正颌外科手术治疗的人(手术组)和 42 名不需要治疗的轻度拥挤患者(对照组)。研究发现,要求进行正颌手术的主要原因是为了改善面部外观,而患者在这方面的期望值很高。通过社会外貌焦虑问卷和期望与满意度问卷,我们研究中 73.97% 的患者表示治疗达到了他们的期望,90.41% 的患者表示对手术的整体效果感到满意。研究还强调了外科医生与患者沟通的重要性,以及患者对最终结果的环境满意度对患者满意度的决定作用。总之,由于患者对正颌外科手术的期望值过高会影响治疗的成功率和患者的满意度,因此在治疗前了解和管理患者的期望值并进行良好的医患沟通对提高患者术后满意度非常重要。
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引用次数: 0
Lateral pterygoid muscle ultrasound-guided injection: A technical note 翼外肌超声引导注射:技术注释。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2023.101547

Background

Temporomandibular disorders (TMDs) are a frequent cause of orofacial pain, causing functional disability and a negative impact on quality of life. Botulinum toxin (BTX-A) injection in lateral pterygoid muscle (LPM) is one of the treatment modalities proposed, but the blind puncture guided by EMG carries a risk of vascular puncture or diffusion of the toxin to nearby muscles. We describe an ultrasound-guided approach and evaluate the spread of the injection in a fresh human cadaver.

Methods

A fresh human cadaver was injected. An out-of-plane approach was performed using a convex probe, injecting 1.0 ml of 0.25% methylene blue dye into the LPM. After, a dissection was performed to isolate the lateral pterygoid muscle and assess the spread of the dye.

Results

Ultrasound-guided injection allowed to visualize in real-time the spread of the dye within the LPM. The deep and superficial muscles nearby to LPM were not stained by the dye, but upper and lower head of LPM was heavily stained.

Conclusion

Ultrasound-guided approach for the injection of BTX-A into the LPM could be considered a successful and safe treatment for myofascial pain related to TMD. Therefore, further clinical studies are needed to study the reproducibility of ultrasound guided LPM injection and to evaluate the clinical results.

背景:颞下颌关节紊乱病(TMDs)是口腔面部疼痛的常见原因,会导致功能残疾,并对生活质量产生负面影响。翼外肌注射肉毒杆菌毒素(BTX-A)是提议的治疗方式之一,但EMG引导的盲穿刺有血管穿刺或毒素扩散到附近肌肉的风险。我们描述了一种超声引导的方法,并评估了注射在新鲜人体尸体中的扩散。方法:新鲜人体尸体注射。使用凸探针进行平面外方法,将1.0ml 0.25%亚甲蓝染料注入LPM中。之后,进行解剖以分离翼外肌并评估染料的扩散。结果:超声引导注射可以实时观察染料在LPM内的扩散。LPM附近的深部和浅部肌肉没有被染料染色,但LPM的上头部和下头部被严重染色。结论:超声引导下将BTX-A注入LPM是治疗TMD相关肌筋膜疼痛的一种成功且安全的方法。因此,需要进一步的临床研究来研究超声引导LPM注射的可重复性并评估临床结果。
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引用次数: 0
Is the modified double-puncture arthrocentesis technique effective in terms of clinical outcomes? 改良的双穿刺关节穿刺技术在临床效果方面是否有效?
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101864

We aimed to compare the clinical results of the modified double-puncture arthrocentesis technique with the results of the conventional double-puncture and single-puncture techniques. Patients who underwent unilateral arthrocentesis and had stage 2–4 internal irregularities according to Wilkes classification were included in the study. The outcome variables were pain, maximum mouth opening, quality of life, and duration of the procedure. Data were analysed preoperatively and 1st-day, 1st-week, and 1st-month after the procedure. A total of 52 patients (49-females, 3-males) with complete records were included in this study. The mean age of the patients was 32.7 ± 15.6 years. There was no significant difference between the three techniques in terms of outcome variables at all times (p > 0.05). There was a significant difference between the single puncture technique and the other techniques in terms of procedure time (p < 0.05). No superiority of the modified double-puncture arthrocentesis was found in terms of clinical results.

我们旨在比较改良双穿刺关节穿刺技术与传统双穿刺和单穿刺技术的临床效果。研究对象包括接受单侧关节穿刺术的患者,根据威尔克斯分类法,患者的内侧不规则程度为 2-4 期。结果变量包括疼痛、最大张口度、生活质量和手术持续时间。对术前、术后第一天、第一周和第一个月的数据进行了分析。本研究共纳入了 52 名病历完整的患者(49 名女性,3 名男性)。患者的平均年龄为(32.7 ± 15.6)岁。在所有时间段内,三种技术的结果变量均无明显差异(> 0.05)。就手术时间而言,单次穿刺技术与其他技术之间存在明显差异(< 0.05)。就临床结果而言,改良的双穿刺关节穿刺术没有优势。
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引用次数: 0
Impact of bone levels on stress distribution around all-on-four concept: A 3-D finite element analysis 骨水平对 "全对四 "概念周围应力分布的影响:三维有限元分析
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101905

This study aimed to investigate the impact of implant placement levels within the bone on stress distribution in the context of the All-on-Four concept. In this Finite Element Analysis(FEA), two 4.1 mm x 10 mm implants were axially placed in the anterior region of the jawbone, while two 4.1 mm x 14 mm implants were tilted at 30 ° in the posterior region following the all-on-four concept. In the EC scenario, all implants were inserted at the equicrestal level. In other scenarios, implants were positioned at 1 mm and 2 mm subcrestal levels (SC1, SC2). In all groups, the prosthesis was designed to replicate a group-function occlusion. A total load of 450 N was applied to the prosthesis. Upon deeper implant placement below the crest level, a trend of decreasing Von Mises stresses was observed in both implants and implant fragments. The highest Pmax value in the bone was recorded in SC-2, characterized by the absence of cortical bone support, with values of 3.16 N/mm2 in the anterior region and 1.55 N/mm2 in the posterior region. Conversely, the lowest Pmax values were noted in SC-1 for the anterior implant (2.67 N/mm2) and the EC for the posterior implant (0.87 N/mm2). Implant placements devoid of cortical bone support result in stress transmission from the implant and its components to the peri-implant bone. Optimal stress minimization is achieved by placing anterior axial angle implants deeper than the crest level while retaining cortical bone support and positioning posterior tilted implants at the crest level.

本研究旨在探讨在 "全牙列 "概念下,骨内种植体植入水平对应力分布的影响。在有限元分析(FEA)中,两颗 4.1 毫米 x 10 毫米的种植体被轴向植入颌骨的前部区域,而两颗 4.1 毫米 x 14 毫米的种植体则按照 "全对四 "概念以 30 °的角度倾斜植入后部区域。在EC方案中,所有种植体都在等嵴水平植入。在其他情况下,种植体分别位于 1 毫米和 2 毫米的胸骨下水平(SC1、SC2)。在所有组中,修复体的设计都是为了复制组功能咬合。修复体的总负荷为 450 N。当种植体植入深度低于嵴水平时,种植体和种植体碎片的 Von Mises 应力均呈下降趋势。骨质中最高的 Pmax 值出现在 SC-2,其特点是没有皮质骨支撑,前部区域为 3.16 N/mm2,后部区域为 1.55 N/mm2。相反,前部种植体 SC-1 的 Pmax 值最低(2.67 N/mm2),后部种植体 EC 的 Pmax 值最低(0.87 N/mm2)。缺乏皮质骨支持的种植体植入会导致应力从种植体及其组件传递到种植体周围的骨质。在保留皮质骨支持的同时,将前侧轴角种植体植入到比嵴水平更深的位置,并将后侧倾斜种植体植入到嵴水平,可以最大限度地减少应力。
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引用次数: 0
Correlations with clinical and radiologic findings and prevalence of osteopenia/osteoporosis in the patients with bilateral temporomandibular joint osteoarthritis 双侧颞下颌关节骨关节炎患者骨质疏松症/骨质疏松症与临床和放射学检查结果及患病率的关系
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101869

This study aimed to evaluate the prevalence of osteopenia/osteoporosis in patients with bilateral temporomandibular joint osteoarthritis (TMJ-OA) and its correlations with clinical and radiological findings. A total of 95 patients with bilateral TMJ-OA diagnosed by CBCT were included in the study. Clinical and radiological findings and bone mineral density (BMD) scores were recorded. Descriptive statistics and the Spearman rho correlation tests were performed. Osteopenia/osteoporosis was found in 44 of 95 patients (46.32 %) (30, osteopenia; 14 osteoporosis). Osteopenia/osteoporosis is significantly associated with postmenopausal status and age over 40 years, but it is not associated with clinical and radiological findings of TMJ-OA. Patients with bilateral TMJ-OA have a high prevalence of osteopenia/osteoporosis.

本研究旨在评估双侧颞下颌关节骨关节炎(TMJ-OA)患者骨质疏松/骨质疏松症的患病率及其与临床和放射学检查结果的相关性。研究共纳入了 95 名经 CBCT 诊断为双侧颞下颌关节骨关节炎(TMJ-OA)的患者。研究记录了临床和放射学检查结果以及骨矿物质密度(BMD)评分。进行了描述性统计和 Spearman rho 相关性测试。95 名患者中有 44 人(46.32%)患有骨质疏松症/骨质疏松症(30 人患有骨质疏松症;14 人患有骨质疏松症)。骨质疏松症/骨质疏松症与绝经后状态和 40 岁以上年龄明显相关,但与颞下颌关节-OA 的临床和放射学结果无关。双侧颞下颌关节-OA 患者骨质疏松/骨质疏松症的发病率很高。
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引用次数: 0
A comprehensive consolidation of data on the relationship between IRF6 polymorphisms and non-syndromic cleft lip/palate susceptibility: From 79 case-control studies IRF6多态性与非综合征性唇腭裂易感性之间关系的综合数据整合:来自79项病例对照研究的数据》(A Comprehensive Consolidation of Data on the Relationship between IRF6 Polymorphisms and Non-Syndromic Cleft Lip/Palate Susceptibility: from 79 Case-Control Studies)。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101809

Background

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a prevalent craniofacial birth defect on a global scale. A number of candidate genes have been identified as having an impact on NSCL/P. However, the association between interferon regulatory factor 6 (IRF6) polymorphisms and NSCL/P has yielded inconsistent results, prompting the need for a meta-analysis to obtain more accurate estimates.

Methods

We conducted a thorough screening of all relevant articles published up until November 15, 2023, in online bibliographic databases. The statistical analysis of the collected data was performed using the Comprehensive Meta-Analysis (Version 4.0) software.

Results

A total of 79 case-control studies, comprising 14,003 cases and 19,905 controls, were included in our analysis. The combined data indicated that the IRF6 rs642961 and rs2235371 polymorphisms were associated with an increased risk of NSCL/P in the overall population. However, no significant association was found between the rs2013162 and rs2235375 polymorphisms and the risk of NSCL/P in the overall population. Furthermore, subgroup analyses revealed significant correlations between the IRF6 rs642961, rs2235371, and rs2235375 polymorphisms and the risk of NSCL/P based on ethnic background and country of origin. Nevertheless, the rs2013162 polymorphism plays a protective role in Caucasians and mixed populations.

Conclusions

Our collective data indicates a significant association between the rs642961 and rs2235371 polymorphisms and the risk of NSCL/P in the overall population. The rs2235375 polymorphism could influence the susceptibility to NSCL/P based on ethnic background. Meanwhile, the rs2013162 polymorphism provides protective effects in Caucasian, mixed populations, and the Brazilian population.

背景:非综合征性唇裂伴或不伴腭裂(NSCL/P)是全球普遍存在的颅面出生缺陷。目前已发现一些候选基因对 NSCL/P 有影响。然而,干扰素调节因子6(IRF6)多态性与NSCL/P之间的关联研究结果并不一致,因此需要进行荟萃分析以获得更准确的估计:我们对在线文献数据库中截至 2023 年 11 月 15 日发表的所有相关文章进行了全面筛选。我们使用综合荟萃分析(4.0 版)软件对收集到的数据进行了统计分析:我们的分析共纳入了 79 项病例对照研究,包括 14 003 例病例和 19 905 例对照。综合数据显示,IRF6 rs642961 和 rs2235371 多态性与总体人群罹患 NSCL/P 的风险增加有关。然而,在总体人群中,rs2013162 和 rs2235375 多态性与 NSCL/P 风险之间没有发现明显的关联。此外,亚组分析显示,基于种族背景和原籍国,IRF6 rs642961、rs2235371 和 rs2235375 多态性与 NSCL/P 风险之间存在显著相关性。然而,rs2013162 多态性在白种人和混血人群中起保护作用:我们的综合数据表明,在总体人群中,rs642961 和 rs2235371 多态性与罹患 NSCL/P 的风险有明显关联。rs2235375多态性可根据种族背景影响NSCL/P的易感性。同时,rs2013162 多态性在白种人、混血人群和巴西人群中具有保护作用。
{"title":"A comprehensive consolidation of data on the relationship between IRF6 polymorphisms and non-syndromic cleft lip/palate susceptibility: From 79 case-control studies","authors":"","doi":"10.1016/j.jormas.2024.101809","DOIUrl":"10.1016/j.jormas.2024.101809","url":null,"abstract":"<div><h3>Background</h3><p><span>Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a prevalent craniofacial birth defect on a global scale. A number of candidate genes have been identified as having an impact on NSCL/P. However, the association between </span>interferon regulatory factor 6 (IRF6) polymorphisms and NSCL/P has yielded inconsistent results, prompting the need for a meta-analysis to obtain more accurate estimates.</p></div><div><h3>Methods</h3><p>We conducted a thorough screening of all relevant articles published up until November 15, 2023, in online bibliographic databases. The statistical analysis of the collected data was performed using the Comprehensive Meta-Analysis (Version 4.0) software.</p></div><div><h3>Results</h3><p>A total of 79 case-control studies, comprising 14,003 cases and 19,905 controls, were included in our analysis. The combined data indicated that the IRF6 rs642961 and rs2235371 polymorphisms were associated with an increased risk of NSCL/P in the overall population. However, no significant association was found between the rs2013162 and rs2235375 polymorphisms and the risk of NSCL/P in the overall population. Furthermore, subgroup analyses revealed significant correlations between the IRF6 rs642961, rs2235371, and rs2235375 polymorphisms and the risk of NSCL/P based on ethnic background and country of origin. Nevertheless, the rs2013162 polymorphism plays a protective role in Caucasians and mixed populations.</p></div><div><h3>Conclusions</h3><p>Our collective data indicates a significant association between the rs642961 and rs2235371 polymorphisms and the risk of NSCL/P in the overall population. The rs2235375 polymorphism could influence the susceptibility to NSCL/P based on ethnic background. Meanwhile, the rs2013162 polymorphism provides protective effects in Caucasian, mixed populations, and the Brazilian population.</p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101809"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The past forty-three years of dental implantology literature. A global mapping and scientometric analysis 过去四十三年的牙科种植文献。全球绘图和科学计量分析。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101945

Purpose

The aim of this research is to make a scientometric analysis of the dental implantology literature and to present the results in a more understandable way to the reader by visualizing them with maps.

Methods

The dental implantology literature was accessed through the Web of Science database. Scientometric data was obtained with Citespace 6.1 software, co-citation, clustering analysis, citation burst, and mapping analyzes were performed. Scimago Graphica software was used for additional visualizations.

Results

A total of 35,704 articles were included in the analysis. There were 88,616 authors, 72,333 institutes, 142 countries/regions, and 3,265 journals contributing to the dental implantology literature. The United States was first with 7,334 publications and 225,868 citations. The literature between 1980 and 2023 was divided into 19 different clusters, and the literature between 2000 and 2023 was divided into 16 different clusters.

Conclusions

Key themes in the field include the use of autogenous bone, advancements in implant surface technology, and the use of platform switching and intraoral scanners. Emerging topics of interest include esthetic considerations in the treatment of the anterior region, stress distribution, the use of zirconia, and the impact of implant treatment on oral health-related quality of life. With similar scientometric analysis studies to be done in the future, the progress of the literature can be followed on the basis of evidence.

目的:本研究旨在对牙科植入学文献进行科学计量学分析,并通过地图直观地展示结果,使读者更容易理解:方法:通过 Web of Science 数据库获取牙科植入学文献。方法:通过 Web of Science 数据库访问牙科植入学文献,使用 Citespace 6.1 软件获取科学计量数据,并进行共引、聚类分析、引文突变和绘图分析。Scimago Graphica 软件用于额外的可视化:共有 35 704 篇文章被纳入分析。共有 88616 位作者、72333 个机构、142 个国家/地区和 3265 种期刊为牙科种植文献做出了贡献。美国以 7,334 篇论文和 225,868 次引用位居第一。1980-2023年间的文献分为19个不同的群组,2000-2023年间的文献分为16个不同的群组:该领域的关键主题包括自体骨的使用、种植体表面技术的进步以及平台切换和口内扫描仪的使用。新出现的主题包括前牙治疗中的美学考虑、应力分布、氧化锆的使用以及种植治疗对口腔健康相关生活质量的影响。今后还将进行类似的科学计量分析研究,可以在证据的基础上跟踪文献的进展。
{"title":"The past forty-three years of dental implantology literature. A global mapping and scientometric analysis","authors":"","doi":"10.1016/j.jormas.2024.101945","DOIUrl":"10.1016/j.jormas.2024.101945","url":null,"abstract":"<div><h3>Purpose</h3><p>The aim of this research is to make a scientometric analysis of the dental implantology literature and to present the results in a more understandable way to the reader by visualizing them with maps.</p></div><div><h3>Methods</h3><p>The dental implantology literature was accessed through the Web of Science database. Scientometric data was obtained with Citespace 6.1 software, co-citation, clustering analysis, citation burst, and mapping analyzes were performed. Scimago Graphica software was used for additional visualizations.</p></div><div><h3>Results</h3><p>A total of 35,704 articles were included in the analysis. There were 88,616 authors, 72,333 institutes, 142 countries/regions, and 3,265 journals contributing to the dental implantology literature. The United States was first with 7,334 publications and 225,868 citations. The literature between 1980 and 2023 was divided into 19 different clusters, and the literature between 2000 and 2023 was divided into 16 different clusters.</p></div><div><h3>Conclusions</h3><p><span>Key themes in the field include the use of autogenous bone, advancements in implant surface technology, and the use of platform switching and intraoral scanners<span>. Emerging topics of interest include esthetic considerations in the treatment of the anterior region, stress distribution, the use of zirconia, and the impact of implant treatment on oral health-related </span></span>quality of life. With similar scientometric analysis studies to be done in the future, the progress of the literature can be followed on the basis of evidence.</p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101945"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology, etiopathogenesis, and management of MRONJ: A European multicenter study MRONJ的流行病学、发病机制和治疗:一项欧洲多中心研究。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101931

Introduction

The purpose of this European multicenter study was to describe the general characteristics and risk factors of MRONJ lesions as well as their clinical diagnosis and management at different European Oral and Maxillofacial Surgery centers, in order to minimize selections biases and provide information about the epidemiology, etiopathogenesis, and the current trends in the treatment of MRONJ across Europe.

Materials and methods

The following data were registered for each patient: gender; age at MRONJ diagnosis; past medical history; indication for antiresorptive or antiangiogenic therapy; type of antiresorptive medication; local risk factor for MRONJ; MRONJ Stage; anatomic location and symptoms; treatment; surgical complications; recurrence.

Results

A total of 537 patients (375 females, 162 males) with MRONJ were included. Statistically significant associations were found between patients with metastatic bone disease and recurrences (P < 0.0005) and between advanced MRONJ stages (stages 2 and 3) and recurrences (P < 0.005). Statistically significant associations were also found between male gender and recurrences (P < 0.05), and between MRONJ maxillary sites and recurrences (P < 0.0000005).

Conclusions

A longer mean duration of antiresorptive medications before MRONJ onset was observed in patients affected by osteoporosis, whereas a shorter mean duration was observed in all metastatic bone cancer patients, and in particular in those affected by prostate cancer with bone metastases or multiple myeloma. Surgery plays an important role for the management of MRONJ lesions.

简介:这项欧洲多中心研究的目的是描述MRONJ病变的一般特征和风险因素,以及欧洲不同口腔颌面外科中心的临床诊断和管理,以尽量减少选择偏差,并提供有关欧洲MRONJ的流行病学、发病机制和当前治疗趋势的信息:对每位患者的以下数据进行登记:性别;MRONJ 诊断时的年龄;既往病史;抗骨吸收或抗血管生成治疗的指征;抗骨吸收药物的类型;MRONJ 的局部危险因素;MRONJ 分期;解剖位置和症状;治疗;手术并发症;复发:共纳入537例MRONJ患者(女性375例,男性162例)。结果:共纳入537名MRONJ患者(女性375人,男性162人),发现转移性骨病患者与复发(P<0.0005)、MRONJ晚期(2期和3期)与复发(P<0.005)之间存在统计学意义上的显著关联。男性性别与复发之间(P < 0.05)、MRONJ上颌骨部位与复发之间(P < 0.0000005)也存在统计学意义:结论:骨质疏松症患者在MRONJ发病前服用抗骨质吸收药物的平均时间较长,而所有转移性骨癌患者,尤其是前列腺癌骨转移患者或多发性骨髓瘤患者服用抗骨质吸收药物的平均时间较短。手术在治疗 MRONJ 病变方面发挥着重要作用。
{"title":"Epidemiology, etiopathogenesis, and management of MRONJ: A European multicenter study","authors":"","doi":"10.1016/j.jormas.2024.101931","DOIUrl":"10.1016/j.jormas.2024.101931","url":null,"abstract":"<div><h3>Introduction</h3><p>The purpose of this European multicenter study was to describe the general characteristics and risk factors of MRONJ<span><span> lesions as well as their clinical diagnosis and management at different European Oral and Maxillofacial Surgery centers, in order to minimize selections biases and provide information about the epidemiology, etiopathogenesis, and the current trends in the treatment of </span>MRONJ across Europe.</span></p></div><div><h3>Materials and methods</h3><p>The following data were registered for each patient: gender; age at MRONJ diagnosis; past medical history<span><span>; indication for antiresorptive or antiangiogenic therapy; type of antiresorptive medication; local risk factor for MRONJ; MRONJ Stage; anatomic location and symptoms; treatment; </span>surgical complications; recurrence.</span></p></div><div><h3>Results</h3><p><span>A total of 537 patients (375 females, 162 males) with MRONJ were included. Statistically significant associations were found between patients with metastatic bone disease and recurrences (</span><em>P</em> &lt; 0.0005) and between advanced MRONJ stages (stages 2 and 3) and recurrences (<em>P</em> &lt; 0.005). Statistically significant associations were also found between male gender and recurrences (<em>P</em> &lt; 0.05), and between MRONJ maxillary sites and recurrences (<em>P</em> &lt; 0.0000005).</p></div><div><h3>Conclusions</h3><p><span><span>A longer mean duration of antiresorptive medications before MRONJ onset was observed in patients affected by osteoporosis, whereas a shorter mean duration was observed in all metastatic bone cancer patients, and in particular in those affected by </span>prostate cancer<span> with bone metastases or </span></span>multiple myeloma. Surgery plays an important role for the management of MRONJ lesions.</p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101931"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is the use of Pentoxifylline and Tocopherol effective in the treatment of Osteoradionecrosis of the jaws or for the treatment of medicationosteonecrosis of the jaw? An overview 使用喷托维林和生育酚治疗颌骨坏死或药物性颌骨坏死是否有效?综述。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101959

Purpose

The aim of the present study was to determine the methodological quality of systematic reviews that evaluated the effectiveness of pentoxifylline and tocopherol (PENTO) in the treatment of osteoradionecrosis of the jaw (ORNJ) and medication-related osteonecrosis of the jaw (MRONJ).

Methods

Searches were performed in Databases including PubMed, Scopus, LILACS, DARE, Cochrane Library, and SIGLE through OpenGrey until March 2024, were evaluated by two independent reviewers to answer the following question: Is the use of PENTO protocol effective in the treatment of ORNJ or for the treatment of MRONJ?

Results

A total of 256 articles were initially identified; however, following the use of appropriate inclusion and exclusion criteria, five systematic reviews were identified for detailed analysis. The final study sample comprised 588 patients: 397 patients with ORN and 197 patients with MRONJ who were treated with PENTO. The total recovery of individuals who used the PENTO protocol was 62,2 % for ORN and 100 % for MRONJ, with a follow-up period of 1 month to 10 years. The methodological quality of the studies was assessed using the AMSTAR 2 tool, in which four were of low quality and 1 moderate quality.

Conclusion

The treatment of ORN and MRONJ with pentoxifylline and tocopherol has shown good results in the studies presented, with a partial or total reduction in bone exposure. However, the low quality of the relevant reports highlights the need for primary and secondary studies with better methodological rigor to reduce bias and provide reassurance for this treatment option.

目的:本研究旨在确定评估喷托维林和生育酚(PENTO)治疗颌骨坏死(ORNJ)和药物相关性颌骨坏死(MRONJ)有效性的系统性综述的方法学质量:通过 OpenGrey 在 PubMed、Scopus、LILACS、DARE、Cochrane Library 和 SIGLE 等数据库中进行检索,直至 2024 年 3 月,并由两名独立审稿人进行评估,以回答以下问题:使用 PENTO 方案治疗 ORNJ 或 MRONJ 是否有效?最初共确定了 256 篇文章;但在使用适当的纳入和排除标准后,确定了五篇系统综述进行详细分析。最终的研究样本包括 588 名患者:其中,397 名 ORN 患者和 197 名 MRONJ 患者接受了 PENTO 治疗。使用 PENTO 方案治疗 ORN 的总康复率为 62.2%,治疗 MRONJ 的总康复率为 100%,随访时间从 1 个月到 10 年不等。研究的方法学质量采用 AMSTAR 2 工具进行评估,其中 4 项为低质量,1 项为中等质量:结论:使用喷托维林和生育酚治疗 ORN 和 MRONJ 的研究结果显示效果良好,部分或全部减少了骨暴露。然而,相关报告的质量较低,这凸显出有必要开展方法更严谨的一级和二级研究,以减少偏倚并为这种治疗方案提供保证。
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引用次数: 0
Clinical evaluation of bone quality of particulate cancellous bone and marrow, and implant prosthetic rehabilitation 对微粒松质骨和骨髓的骨质以及植入假体康复进行临床评估。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jormas.2024.101862

This study aimed to subjectively evaluate bone quality in the particulate cancellous bone and marrow (PCBM) graft area and to assess the survival rates of implants.

A retrospective review was conducted based on patient age, sex, diagnosis, reconstructed site, number of implants, prosthetic type, and duration of follow-up. Images from computed tomography (CT) before implant insertion were obtained and used in this study. We selected a 4.0-mm diameter × 8.0-mm length region of interest in the implant placement area, and measured the CT attenuation value.

No significant correlations were seen between CT attenuation values and implant survival rates in the maxilla and mandible. On the other hand, CT attenuation values and implant survival rates were significantly lower in patients with malignancy than in non-malignant cases.

Placing implants in PCBM grafted bone requires a full understanding of bone quality before surgery and drilling to ensure primary stability, along with consideration of soft tissue management and maintenance programs.

本研究旨在对微粒松质骨和骨髓(PCBM)移植区的骨质进行主观评估,并评估植入物的存活率。根据患者的年龄、性别、诊断、重建部位、植入数量、假体类型和随访时间进行了回顾性分析。本研究使用了植入前的计算机断层扫描(CT)图像。我们在植入区域选择了一个直径为 4.0 毫米 × 长度为 8.0 毫米的感兴趣区,并测量了 CT 的衰减值。在上颌骨和下颌骨中,CT 衰减值与种植体存活率之间没有明显的相关性。另一方面,恶性肿瘤患者的 CT 衰减值和种植体存活率明显低于非恶性肿瘤患者。在 PCBM 移植骨中植入种植体需要在手术和钻孔前充分了解骨质情况,以确保主要稳定性,同时还要考虑软组织管理和维护计划。
{"title":"Clinical evaluation of bone quality of particulate cancellous bone and marrow, and implant prosthetic rehabilitation","authors":"","doi":"10.1016/j.jormas.2024.101862","DOIUrl":"10.1016/j.jormas.2024.101862","url":null,"abstract":"<div><p>This study aimed to subjectively evaluate bone quality in the particulate cancellous bone and marrow (PCBM) graft area and to assess the survival rates of implants.</p><p>A retrospective review was conducted based on patient age, sex, diagnosis, reconstructed site, number of implants, prosthetic type, and duration of follow-up. Images from computed tomography<span> (CT) before implant insertion were obtained and used in this study. We selected a 4.0-mm diameter × 8.0-mm length region of interest in the implant placement area, and measured the CT attenuation value.</span></p><p>No significant correlations were seen between CT attenuation values and implant survival rates in the maxilla<span><span> and mandible. On the other hand, CT attenuation values and implant survival rates were significantly lower in patients with </span>malignancy than in non-malignant cases.</span></p><p>Placing implants in PCBM grafted bone requires a full understanding of bone quality before surgery and drilling to ensure primary stability, along with consideration of soft tissue management and maintenance programs.</p></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"125 5","pages":"Article 101862"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Stomatology Oral and Maxillofacial Surgery
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