Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"The association between common NSAID use and early dental implant failure: A large-scale retrospective cohort study","authors":"Georgios S. Chatzopoulos ,&nbsp;Larry F. Wolff","doi":"10.1016/j.jormas.2025.102680","DOIUrl":"10.1016/j.jormas.2025.102680","url":null,"abstract":"<div><h3>Introduction</h3><div>The impact of NSAIDs on osseointegration remains controversial, with conflicting evidence from animal models and human clinical trials. The aim of the study was to investigate the association between the use of common Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and the risk of early dental implant failure in a large, real-world patient cohort.</div></div><div><h3>Methods</h3><div>This retrospective cohort study utilized an EHR database of 12,943 patients receiving 49,997 implants. Patients were divided into an NSAID group (<em>n</em> = 3133) and a non-NSAID control group (<em>n</em> = 9810). The primary outcome was early implant failure, defined as implant removal within six months of placement. Multivariable logistic regression models were used to calculate Odds Ratios (ORs) for failure, adjusting for patient age, gender, history of diabetes, and history of osteoporosis. Analyses were conducted at both the implant and patient levels.</div></div><div><h3>Results</h3><div>Patients in the NSAID group were significantly older (62.8 vs. 58.7 years, <em>p</em> &lt; 0.0001) and had a higher prevalence of diabetes (22.0% vs. 16.7 %, <em>p</em> &lt; 0.0001) and osteoporosis (11.0 % vs. 7.0 %, <em>p</em> &lt; 0.0001). After adjusting for confounders, implant-level analysis showed that Ibuprofen use (OR 2.29; 95 % CI 1.48–3.55; <em>p</em> &lt; 0.0001) and Naproxen use (OR 2.65; 95 % CI 1.22–5.75; <em>p</em> = 0.0137) were significantly associated with increased odds of early failure. At the patient level, the association remained highly significant for Ibuprofen (OR 2.87; 95 % CI 1.83–4.51; <em>p</em> &lt; 0.0001), but not for Naproxen (<em>p</em> = 0.0689).</div></div><div><h3>Conclusion</h3><div>The use of Ibuprofen and, to a lesser extent, Naproxen, is associated with a significantly increased risk of early dental implant failure, independent of other patient risk factors. Clinicians should consider these findings when formulating post-operative analgesic plans, particularly for patients with complex medical histories.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102680"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing AI-driven clinical anamnesis: Insights from a comparative evaluation of large language models in oral and maxillofacial diagnosis","authors":"Weihao Cheng","doi":"10.1016/j.jormas.2025.102682","DOIUrl":"10.1016/j.jormas.2025.102682","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102682"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VEGF mRNA expression as a powerful independent predictor for recurrence in ameloblastoma: Integrating molecular profiling with surgical outcome analysis","authors":"Yao Li ,&nbsp;Ke Liu ,&nbsp;Yifan Lu ,&nbsp;Min Gan","doi":"10.1016/j.jormas.2025.102700","DOIUrl":"10.1016/j.jormas.2025.102700","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate vascular endothelial growth factor (VEGF) mRNA expression as an independent biomarker for predicting recurrence in ameloblastoma (AM), and to evaluate its potential for guiding surgical strategy.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted involving 200 patients with primary AM undergoing initial surgery during January 2021-December 2023. Patients were categorized into curettage (<em>n</em> = 77) and extended resection (<em>n</em> = 123) groups. Relative VEGF mRNA expression in the tumor cyst wall was quantified using RT-qPCR. Kaplan-Meier analysis and Cox regression were used to analyze recurrence-free survival (RFS) and risk factors. Perioperative outcomes and complications were compared between groups. Univariate and multivariate analyses were performed using Cox proportional hazards regression models.</div></div><div><h3>Results</h3><div>VEGF mRNA expression was significantly elevated in the recurrence group (4.66 ± 1.42) versus the non-recurrence group (3.24 ± 2.02, <em>P</em> &lt; 0.001). ROC curve analysis identified an optimal VEGF cutoff value of 4.88 for predicting recurrence (AUC = 0.694). This molecular stratification revealed a profound disparity: the 2-year RFS was significantly lower in the VEGF-high group (77.4 %) compared to the VEGF-low group (94.9 %, <em>P</em> &lt; 0.001). While extended resection provided a higher 2-year RFS than curettage (96.0 % vs. 79.5 %, <em>P</em> &lt; 0.001), it incurred greater operative burden and complication risks. Crucially, multivariate analysis established high VEGF expression as the most powerful independent predictor of recurrence (HR = 45.15, <em>P</em> &lt; 0.001), with a risk magnitude exceeding that of curettage (HR = 37.22, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>High VEGF mRNA expression is a powerful, independent biomarker for AM recurrence, with a prognostic impact surpassing surgical choice. Preoperative VEGF assessment holds significant potential for guiding individualized surgical planning and optimizing follow-up strategies.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102700"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A three-dimensional comparison of the upper airway between patients with non-syndromic cleft lip and palate and skeletal class I individuals","authors":"Jiali Shi ,&nbsp;Ruofan Jin ,&nbsp;Nan Zhang ,&nbsp;Fei Liu ,&nbsp;Jinwei Qin ,&nbsp;Wei Hou ,&nbsp;Weina Zhou","doi":"10.1016/j.jormas.2025.102668","DOIUrl":"10.1016/j.jormas.2025.102668","url":null,"abstract":"<div><h3>Introduction</h3><div>To compare the upper airway dimensions between patients with non-syndromic cleft lip and palate (NSCLP) and skeletal class I control group using three-dimensional imaging.</div></div><div><h3>Methods</h3><div>Using a retrospective cohort study, the investigators enrolled a sample of patients from the Orthodontic Department of the Affiliated Stomatological Hospital of Nanjing Medical University during 2014 and 2018. The primary predictor variable was dentofacial skeleton (NSCLP vs. skeletal class I). The main outcome was three-dimensional upper airway morphology, which included volume, minimum cross-sectional area, height, and symmetry. Appropriate statistics were computed using <em>P</em> &lt; 0.05 as statistical significance.</div></div><div><h3>Results</h3><div>The study included 51 NSCLP patients and 53 class I controls, with comparable age and gender distribution. Three-dimensional analysis revealed significant morphological differences: compared to the class I group, NSCLP patients exhibited a larger nasopharyngeal volume (<em>p</em> &lt; 0.01) and a larger minimum cross-sectional area in the nasopharynx (<em>p</em> &lt; 0.05) and palatopharynx (<em>p</em> &lt; 0.01), but a reduced height of the upper airway (<em>p</em> &lt; 0.05) and palatopharyngeal airway (<em>p</em> &lt; 0.01). Furthermore, in unilateral NSCLP patients, the transverse diameters of the nasopharynx and palatopharynx were significantly smaller on the affected side compared to the normal side (<em>p</em> &lt; 0.05). While bilateral NSCLP and class I groups demonstrated symmetry at the nasopharyngeal and palatopharyngeal levels, both exhibited significant asymmetry at the glossopharyngeal segment (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Our findings conclusively define the specific three-dimensional differences in the NSCLP upper airway, which include an enlarged yet foreshortened nasopharynx and consistent lateral asymmetries. These structural nuances must be considered in the interdisciplinary management of cleft lip and palate to optimize functional and structural results.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102668"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of mandibular defects using free fibula flaps with a spliced surgical template system","authors":"Wei Cao ,&nbsp;PengFei Zhao ,&nbsp;Zhang Zhao ,&nbsp;YiMing Chen","doi":"10.1016/j.jormas.2025.102705","DOIUrl":"10.1016/j.jormas.2025.102705","url":null,"abstract":"<div><h3>Background</h3><div>Mandibular defect reconstruction after tumor resection poses significant challenges in oral and maxillofacial surgery. The free fibula flap is widely used and effective for reconstructing such defects. Traditional manual segmentation and stabilization can lead to inaccuracies; while 3D-printed guides improve cutting precision, they often overlook the stabilization of bone segments. The conventional surgical template system consists of three separate guides: a tumor removal guide, a fibula cutting guide, and a reconstruction guide, which requires manual detachment and reshaping of fibula segments before reconstruction. In contrast, the spliced surgical template system integrates an additional fibula cutting frame and reconstruction frame. This allows the fibula cutting guides to transform directly into the reconstruction guide without detaching the segments, thereby simplifying the workflow and improving stabilization accuracy. This study evaluates a spliced surgical template system and compares its accuracy in stabilizing bone segments with that of conventional systems.</div></div><div><h3>Patient and method</h3><div>A retrospective cohort study was conducted for patients who underwent mandibular tumor resection and free fibula flap reconstruction at Shanghai Ninth People’s Hospital from 01/01/2022 to 31/03/2025. Patients were divided into two groups based on whether they used conventional or spliced surgical template systems. Preoperative virtual surgical planning was adapted to create 3D models, cutting guides, and reconstructing guides. Postoperative CT scans were also analyzed to assess reconstruction accuracy by measuring deviations in three dimensions.</div></div><div><h3>Result</h3><div>20 patients were included; 10 used the spliced surgical template system, and the rest used the conventional ones. The spliced system showed significantly more minor errors in reconstruction accuracy than the other. The offset was X-axis 0.31 [0.13, 0.97] mm, Y-axis 0.32 [0.11, 0.78] mm, and Z-axis 0.37 [0.06, 0.47] mm for the spliced system, versus 4.03 [0.61, 18.49] mm, 3.50 [0.66, 13.94] mm, and 3.14 [0.85, 7.25] mm for the conventional system, which were all statistically significant (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The spliced surgical template system provides higher accuracy and stability in mandibular reconstruction with the free fibula flap. It reduces errors in the positioning of fibula segments, resulting in improved reconstruction precision and potentially contributing to better functional outcomes compared with conventional methods.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102705"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early postoperative occlusal intervention in patients with maxillofacial trauma and malocclusion: Impact on mandibular function recovery","authors":"Guanglian Yang,&nbsp;Linkai Deng","doi":"10.1016/j.jormas.2025.102696","DOIUrl":"10.1016/j.jormas.2025.102696","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of early postoperative occlusal intervention on mandibular border movement and functional recovery in patients with maxillofacial trauma and malocclusion.</div></div><div><h3>Methods</h3><div>In this retrospective 1:1 matched study, 184 patients treated during December 2019 to December 2023 were allocated to intervention (<em>n</em> = 92) and control (<em>n</em> = 92) groups. Controls received conventional postoperative care. The intervention group received additional systematic occlusal intervention initiated within one week post-surgery, comprising intermaxillary traction, occlusal splint therapy, and targeted occlusal training. Outcomes assessed included the mandibular border movement index (MBMI), Visual Analogue Scale (VAS), pressure pain threshold (PPT), Jaw Functional Limitation Scale (JFLS), and Oral Health Impact Profile-5 (OHIP-5). Complications were also recorded.</div></div><div><h3>Results</h3><div>At 3 months, both groups showed significant improvement in all MBMI parameters (maximum mouth opening, protrusion, lateral excursions) and the composite score, with the intervention group demonstrating superior outcomes (<em>P</em> &lt; 0.05). The intervention group also exhibited significantly greater reductions in VAS scores and greater increases in PPT (<em>P</em> &lt; 0.05). Similarly, significantly greater improvements were observed in the intervention group for all JFLS domains (mastication, vertical mobility, emotional/verbal expression) and OHIP-5 items, along with their total scores (<em>P</em> &lt; 0.05). The complication rate did not differ significantly between groups (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Early systematic occlusal intervention effectively promotes mandibular border movement recovery, alleviates orofacial pain, and enhances jaw function and oral health-related quality of life in patients with maxillofacial trauma and malocclusion, without increasing complication risks, representing a safe and effective adjunctive treatment strategy.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102696"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it time to reconsider chronic electromagnetic field exposure as a possible risk factor in oral cancer?","authors":"Nitya Krishnasamy ,&nbsp;Hema Shree K","doi":"10.1016/j.jormas.2025.102703","DOIUrl":"10.1016/j.jormas.2025.102703","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral squamous cell carcinoma (OSCC) is a major global health burden, traditionally associated with tobacco, alcohol, and betel quid. In recent years, however, cases have emerged among individuals without these classic risk factors. Chronic exposure to electromagnetic fields (EMFs) from mobile phones and wireless devices has been classified as possibly carcinogenic, yet its potential role in oral carcinogenesis has not been systematically studied.</div></div><div><h3>Technical Note</h3><div>This article highlights the biological plausibility that prolonged, localized EMF exposure may contribute to DNA damage, oxidative stress, and epigenetic modifications in oral epithelial tissues. Evidence from pilot cytogenetic studies, <em>in vitro</em> models, and limited epidemiological data observed increased micronucleus frequency and altered cellular stress responses in buccal mucosal cells of long-term mobile phone users. While direct causal data in OSCC remain absent, these findings suggest that EMFs could act alone or in synergy with established carcinogens.</div></div><div><h3>Discussion</h3><div>The technical note underscores the urgent need for <em>in vitro, in vivo</em>, and epidemiological studies to evaluate whether chronic EMF exposure contributes to oral carcinogenesis. Recognizing this hypothesis is not alarmist but rather a call for rigorous and unbiased investigation. If validated, such evidence could inform preventive guidelines and public health policy for emerging exposures.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102703"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of minimally invasive bone grafting integrated with concentrated growth factor for periodontitis","authors":"Yi Gan ,&nbsp;Xudong Su ,&nbsp;Rong Yuan","doi":"10.1016/j.jormas.2025.102645","DOIUrl":"10.1016/j.jormas.2025.102645","url":null,"abstract":"<div><h3>Objective</h3><div>Periodontitis is a prevalent chronic inflammatory disease characterized by progressive destruction of periodontal tissues, with alveolar bone defects posing significant challenges for clinical treatment. This research aimed to ascertain the clinical efficacy of minimally invasive bone grafting combined with concentrated growth factor (CGF) for treating periodontitis.</div></div><div><h3>Methods</h3><div>Seventy-eight patients with periodontitis and bone defects were randomized into the control group (received guided tissue regeneration (GTR) combined with bone grafting treatment) and the test group (received GTR combined with minimally invasive bone grafting and CGF treatment). Postoperative pain at 1 day, 3 days, and 7 days postoperatively, mucosal healing at 7 days postoperatively, probing depth (PD), clinical attachment level (CAL), gingival recession depth (GRD), bleeding index (BI), gingival index (GI), and the alveolar bone defect depth preoperatively and at 6 months postoperatively were compared, changes in implant new bone thickness and density at 3 and 6 months postoperatively were tested by cone-beam computed tomography (CBCT), and implantation success rate and postoperative complications were compared.</div></div><div><h3>Results</h3><div>The test group exhibited lower pain scores at 3 and 7 days (<em>P</em> &lt; 0.05), improved mucosal healing (<em>P</em> &lt; 0.05), and superior periodontal indicators (PD, CAL, GRD, BI, GI) at 6 months (<em>P</em> &lt; 0.05). CBCT revealed greater bone thickness/density in the test group (<em>P</em> &lt; 0.05). Complication rates were lower in the test group (<em>P</em> &lt; 0.05), with no significant difference in implantation success (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Minimally invasive bone grafting combined GTR with CGF improves periodontal conditions in patients with periodontitis complicated by bone defects, achieves good bone regeneration results, and reduces postoperative complications.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102645"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simplifying intermaxillary fixation in orthognathic surgery using customized surgical archwire with clear aligners: a technical note and exemplifying case","authors":"Solène Chanteux ,&nbsp;Cyril Debortoli ,&nbsp;Frédérique Bally-Genet ,&nbsp;Barbara Lerhe ,&nbsp;Charles Savoldelli","doi":"10.1016/j.jormas.2025.102662","DOIUrl":"10.1016/j.jormas.2025.102662","url":null,"abstract":"<div><h3>Background</h3><div>Clear aligners are increasingly integrated into orthognathic surgery workflows. However, the lack of rigid intraoperative anchorage limits their use to mild or moderate cases, as aligners alone cannot ensure stable intermaxillary fixation.</div></div><div><h3>Objective</h3><div>To describe a simplified, reproducible, and cost-effective technique using a customized cobalt–chromium surgical archwire that enables stable intermaxillary fixation in patients treated with clear aligners.</div></div><div><h3>Technical note</h3><div>A 47-year-old woman with skeletal Class III malocclusion underwent bimaxillary orthognathic surgery under aligner treatment. A CAD-designed cobalt–chromium archwire with interdental posts was bonded using a conventional three-step adhesive protocol. The procedure required approximately 25 min and allowed precise intraoperative traction without detachment or deformation. The optional use of a silicone positioning key improved bonding accuracy and reproducibility.</div></div><div><h3>Conclusion</h3><div>This technique provides rigid and evenly distributed anchorage without removing aligner attachments or adding brackets or screws. By enabling stable intra- and postoperative fixation, it removes a key limitation of aligner-based surgical planning. This expands the applicability of clear aligners to more complex orthognathic cases, such as segmental osteotomies or asymmetrical corrections, and improves the integration of aligners into modern surgical workflows.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102662"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145566300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of perioperative mortality in 66 patients with head and neck cancer: A retrospective study","authors":"Pengfei Zhao ,&nbsp;Xinyi Lin ,&nbsp;Wei Li ,&nbsp;Yiming Chen","doi":"10.1016/j.jormas.2025.102624","DOIUrl":"10.1016/j.jormas.2025.102624","url":null,"abstract":"<div><h3>Background</h3><div>To investigate the characteristics, causes, and risk factors of perioperative mortality (POM) in patients undergoing surgery for head and neck cancer (HNC).</div></div><div><h3>Patients and Methods</h3><div>Medical records of HNC patients treated between 1999 and 2024 were reviewed. Sixty-six patients who experienced POM were identified and compared with 132 matched controls (matched for tumor site, stage, and type of surgery). Data included demographics, comorbidities, tumor features, treatment history, perioperative management, and causes of death. POM causes were categorized as surgical, medical, mixed, or personal. Risk factors were assessed using univariate and multivariate logistic regression.</div></div><div><h3>Results</h3><div>Among 198 patients (66 POM, 132 controls), those with POM were older, had more comorbidities, advanced disease, and prior radiotherapy. They also showed higher ASA grades, longer operations, greater blood loss, and more frequent tracheotomy (all p &lt; 0.05). Most deaths occurred postoperatively, with medical complications predominating. Independent predictors of POM were comorbidities, advanced stage, ASA grade &lt;III, blood loss &gt;600 ml, and tracheotomy.</div></div><div><h3>Conclusion</h3><div>Perioperative mortality in HNC surgery results from multifactorial causes, with both surgical and medical complications contributing significantly. Identifying high-risk patients based on preoperative status and operative parameters may help optimize perioperative care and reduce mortality.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 2","pages":"Article 102624"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}