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Complications of preseptal versus retroseptal transconjunctival approach for isolated orbital floor fracture repair: A double-blind, non-inferiority, randomized, split-face controlled trial 眶前与眶后经结膜入路进行孤立性眶壁骨折修补术的并发症:双盲、非劣效、随机、分面对照试验。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101958

Introduction

Effective surgical access to the orbital floor facilitates surgery and mitigates postoperative complications (PC). The aim of this study was to compare PC between the preseptal and retroseptal transconjunctival approaches (PS-TCA/RS-TCA) for isolated orbital floor fracture (OFF).

Materials and Methods

Using a double-blind, non-inferiority, randomized, split-face study design, patients aged ≥ 18 years with bilateral isolated OFF were enrolled. A sample size of 177 eyes per group was determined through power analysis. The primary predictor variable was the surgical approach, and the main outcome was the PC rate at month 6. Statistical analyses were computed with a significance level at 0.05 and the non-inferiority margin at a relative risk (RR) of 0.045.

Results

The final sample included 193 patients (23.3 % female; age, 42.8 ± 18.1 years). Both TCA variants exhibited comparable PC rates (5.2 % for PS-TCA vs. 7.3 % for RS-TCA; P = 0.53; absolute risk, +2.07 % [95 % CI, -2.74 % to 6.89 %]; RR, 1.4 [95 % CI, 0.64 to 3.07]). Approximately one in every 49 patients experiencing PC with RS-TCA (number needed to harm, 48.3).

Conclusions

Both TCA methods can be used without different PC rates at 6 months postoperatively. Future research should focus on TCA in combination with other surgical approaches for multiple orbital wall reconstruction.
导言:有效的眶底手术入路有助于手术的顺利进行并减少术后并发症(PC)。本研究旨在比较经结膜前路和经结膜后路(PS-TCA/RS-TCA)治疗孤立性眶底骨折(OFF)的PC情况:采用双盲、非劣效、随机、分面研究设计,招募年龄≥ 18 岁的双侧孤立性眶底骨折(OFF)患者。通过功率分析确定每组样本量为 177 只眼睛。统计分析的显著性水平为 0.05,非劣效边际相对风险(RR)为 0.045:最终样本包括 193 名患者(23.3% 为女性;年龄为 42.8±18.1 岁)。两种 TCA 变体的 PC 发生率相当(PS-TCA 为 5.2% vs. RS-TCA 为 7.3%;P = 0.53;绝对风险为 +2.07% [95% CI, -2.74% to 6.89%];RR 为 1.4 [95% CI, 0.64 to 3.07])。大约每 49 名患者中就有一人使用 RS-TCA 进行 PC 治疗(伤害所需人数为 48.3):两种 TCA 方法在术后 6 个月的 PC 发生率并无差异。未来的研究重点应放在 TCA 与其他手术方法相结合的多眶壁重建上。
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引用次数: 0
Self-inflicted crossbow injury in the head: A case report 弩头自伤1例。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2023.101529
Injuries and deaths from crossbows are uncommon, especially when self-inflicted. We present here the case of a 45 years old patient with history of mental illness, who attempted suicide with a crossbow. The bolt penetrated the chin, crossed the oral floor, the oral cavity, the bony palate, the left nasal cavity and exited at the level of the nasal bones.
The main concern was the management of the airways, before proceeding to the removal of the bolt. A nasotracheal intubation through the right nasal cavity while the patient was conscious was performed, but the instruments needed for an emergency tracheotomy were in the operating room in case of failure. The intubation was successful, he underwent general anesthesia, and the bolt was removed from the face.
弩造成的伤亡并不常见,尤其是自己造成的伤亡。我们在这里介绍一个有精神病史的45岁患者的案例,他试图用弩自杀。螺栓穿过下巴,穿过口底、口腔、硬腭、左鼻腔,并在鼻骨水平处离开。在拆除螺栓之前,主要关注的是气道的管理。在患者清醒的情况下,通过右鼻腔进行了鼻气管插管,但紧急气管切开所需的仪器在手术室,以防出现故障。插管成功,他接受了全身麻醉,并从脸上取下了螺栓。
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引用次数: 0
Elevated TRPV2 expression in the facial nerve of rats by cold stimulation: Implications for Bell's palsy 冷刺激导致大鼠面神经中 TRPV2 表达升高:对贝尔麻痹的影响
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101895

Objective

Bell's palsy, also referred to as clinical manifestations of unilateral facial nerve palsy, encompasses downward angling of the corners of the mouth, the absence of forehead creases, and unilateral incomplete eyelid closure. The incidence of Bell's palsy has increased progressively in recent years, but the underlying mechanism of its occurrence remains unknown; therefore, it is essential to investigate both the cause and treatment of Bell's palsy. Member 2 of the Subfamily V Transient Receptor Potential Cation Channel is a mechanically and thermally sensitive ion channel that plays a crucial role in neural growth and development. Using a novel modeling technique, we endeavored to develop an animal model of Bell's palsy and determine whether TRPV2 expression is altered throughout the course of a facial nerve injury.

Materials and methods

The rats were categorized into 3 groups, and their facial nerve function was assessed using RT-qPCR, WB, and pathologic testing, respectively, after undergoing unilateral cold air stimulation for 1, 3, and 7 days. TRPV2 expression was identified using these techniques.

Results

In response to cold stimulation, rats exhibited facial nerve paralysis symptoms, demyelinating lesions in the facial nerve, and increased TRPV2 expression.

Conclusions

Extended cold stimulation of the facial nerve in rats may lead to an imbalance in facial nerve homeostasis and increased TRPV2 expression. These findings will contribute to the understanding of the potential mechanism by which cold stimulation affects the facial nerve. Moreover, this finding implies that TRPV2 could possibly function as an additional diagnostic marker or therapeutic target in the context of Bell's palsy.
贝尔氏麻痹也被称为单侧面神经麻痹的临床表现,包括嘴角向下倾斜、前额无皱纹和单侧眼睑闭合不全。近年来,贝尔氏麻痹的发病率逐渐上升,但其发生的内在机制仍然不明,因此,研究贝尔氏麻痹的病因和治疗方法至关重要。瞬态受体电位阳离子通道 V 亚家族成员 2 是一种对机械和热敏感的离子通道,在神经生长和发育过程中起着至关重要的作用。我们采用一种新颖的建模技术,试图建立贝尔氏麻痹的动物模型,并确定在面神经损伤的整个过程中,TRPV2 的表达是否会发生改变。我们将大鼠分为三组,在单侧冷空气刺激 1 天、3 天和 7 天后,分别使用 RT-qPCR、WB 和病理测试评估它们的面神经功能。通过这些技术确定了 TRPV2 的表达。在冷刺激下,大鼠表现出面神经麻痹症状、面神经脱髓鞘病变以及 TRPV2 表达增加。对大鼠面神经的长时间冷刺激可能会导致面神经平衡失调和TRPV2表达增加。这些发现将有助于人们了解冷刺激影响面神经的潜在机制。此外,这一发现还意味着 TRPV2 有可能成为贝尔氏麻痹的另一个诊断标记或治疗靶点。
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引用次数: 0
Effectiveness of immune checkpoint inhibitors in the treatment of kidney cancer oral metastasis. A case report 免疫检查点抑制剂治疗肾癌口腔转移的疗效。病例报告。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101913
Oral cavity metastasis from renal cell carcinoma is rare with poor prognosis. Recently immune checkpoint inhibitors (ICIs) have shown promising outcomes in the treatment of advanced RCC. Herein, we report a case of palatal lesion mimicking vascular tumor in a 60-year-old woman with locally advanced kidney cancer (T3aN0M0). She underwent an excisional biopsy, and histopathological examinations revealed an oral metastasis from clear cell renal cell carcinoma (ccRCC). The patient was treated with a combination of two ICIs with nivolumab, a programmed death 1 (PD-1), and ipilimumab, a cytotoxic T-lymphocyte-associated antigen 4 (CTLA4). After 3 cycles of systemic immunotherapy, the palate was completely well healed and after 13 months of follow-up, there was no evidence of recurrence. Regarding treatments, radical surgery is often recommended due to a high local control in case of solitary lesions or oligo-metastases. However, this option therapy is associated with a poor quality of life. To the best of our knowledge, this is the first case to suggest the benefits of ICIs in the treatment of oral metastases from ccRCC. Combining ICIs with conservative surgery could be another treatment option for oral metastasis in patients with renal cell carcinoma.
肾细胞癌口腔转移十分罕见,且预后不良。最近,免疫检查点抑制剂(ICIs)在晚期肾细胞癌的治疗中显示出良好的疗效。在此,我们报告了一例腭部病变模拟血管瘤的病例,患者是一名60岁的女性,患有局部晚期肾癌(T3aN0M0)。她接受了切除活检,组织病理学检查显示她的口腔转移灶来自透明细胞肾细胞癌(ccRCC)。患者接受了两种 ICIs 的联合治疗,一种是程序性死亡 1(PD-1)的 nivolumab,另一种是细胞毒性 T 淋巴细胞相关抗原 4(CTLA4)的 ipilimumab。经过 3 个周期的全身免疫治疗后,腭部完全愈合,经过 13 个月的随访,没有发现复发迹象。在治疗方面,由于单发病灶或少转移灶的局部控制率较高,通常建议采用根治性手术治疗。然而,这种治疗方法会带来较差的生活质量。据我们所知,这是第一例表明 ICIs 对治疗 ccRCC 口腔转移瘤有益处的病例。将 ICIs 与保守手术相结合可能是肾细胞癌患者口腔转移的另一种治疗选择。
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引用次数: 0
An acute erosivobullous stomatitis: A diagnostic challenge 急性糜烂性口腔炎:诊断难题。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101929
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引用次数: 0
Accuracy of dental implants positioning in computer-assisted surgeries: In vitro study 计算机辅助手术中牙科植入物定位的准确性:体外研究。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101828

Objectives

The aim of this study is to presents an experimental method for surgical guide confection using an intraoral scanner to obtain a 3D model of the patient's complete denture and compare its accuracy with the conventional methodology using computed tomography.

Study design

This prospective in-vitro study used 30 polyurethane pre-manufactured mandibles which were divided into two groups, conventional technique (group I) and a new method using intraoral scanner (group II), establishing the virtually planned position of the dental implants as a control group, considered as the gold standard for postoperative comparison.

Results

The difference between these methods is close to zero and not statistically significant (p > 0.05), being heigh deviation (Xh) with p:0.130 and angulation difference of dental implants between the groups (Ang) with p:0.396.

Conclusion

The acquisition of stereolithography image of the prosthesis using an intraoral scanner has a clinically acceptable accuracy, being in agreement with the conventional method.
研究目的本研究旨在介绍一种使用口内扫描仪获得患者全口义齿三维模型的手术导板制作实验方法,并将其准确性与使用计算机断层扫描的传统方法进行比较:这项前瞻性体外研究使用了 30 个聚氨酯预制下颌骨,将其分为两组,即传统技术组(I 组)和使用口内扫描仪的新方法组(II 组):结果:这些方法之间的差异接近零,无统计学意义(P>0.05),其中高偏差(Xh)P:0.130,组间种植体角度差异(Ang)P:0.396:使用口内扫描仪获取修复体的立体光刻图像在临床上具有可接受的准确性,与传统方法一致。
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引用次数: 0
Extracellular vesicles in oral oncology: interplay between the tumor microenvironment and disease progression 口腔肿瘤学中的细胞外囊泡:肿瘤微环境与疾病进展之间的相互作用。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101964
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引用次数: 0
Filler found in bone: Surgical removal of polyacrylamide hydrogel (Amazingel) from the mandible after 24 years: A case report and literature review 骨骼中发现的填充物:24 年后从下颌骨中手术取出聚丙烯酰胺水凝胶(Amazingel):病例报告和文献综述。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101962
Polyacrylamide hydrogel (PAAG) is widely regarded as a safe soft tissue filler and has been extensively utilized for cosmetic enhancements, such as breast and facial augmentation in China from 1997 until its ban in 2006. Common complications associated with its use include inflammation, infection, granulomas, fibrosis, gel migration, and facial and soft tissue deformities. This case report describes a 45-year-old Chinese woman who experienced PAAG migration into her mandible 24 years after facial augmentation, causing irritation of the mandibular alveolar nerve - apparently the first documented instance of this occurrence. Surgical intervention was necessary to remove the migrated gel and associated calcifications. A literature review explored adverse events and management strategies for PAAG complications in cosmetic procedures. While generally considered safe, this report underscores the importance of meticulous injection techniques and careful anatomical site selection to prevent such severe complications.
聚丙烯酰胺水凝胶(PAAG)被广泛认为是一种安全的软组织填充剂,自 1997 年起在中国被广泛用于整形美容,如隆胸和隆脸,直至 2006 年被禁用。使用这种材料常见的并发症包括炎症、感染、肉芽肿、纤维化、凝胶移位以及面部和软组织畸形。本病例报告描述了一位 45 岁的中国女性,在面部隆鼻 24 年后,PAAG 移入下颌骨,导致下颌牙槽神经受到刺激,这显然是首次出现这种情况。必须进行手术治疗,以清除移位的凝胶和相关钙化物。文献综述探讨了美容手术中 PAAG 并发症的不良事件和处理策略。虽然普遍认为 PAAG 是安全的,但该报告强调了细致的注射技术和仔细选择解剖部位对预防此类严重并发症的重要性。
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引用次数: 0
A deep learning approach to detection of oral cancer lesions from intra oral patient images: A preliminary retrospective study 从口腔内患者图像中检测口腔癌病变的深度学习方法:初步回顾性研究。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101975
Gaye Keser , Filiz Namdar Pekiner , İbrahim Şevki Bayrakdar , Özer Çelik , Kaan Orhan

Introduction

Oral squamous cell carcinomas (OSCC) seen in the oral cavity are a category of diseases for which dentists may diagnose and even cure. This study evaluated the performance of diagnostic computer software developed to detect oral cancer lesions in intra-oral retrospective patient images.

Materials and methods

Oral cancer lesions were labeled with CranioCatch labeling program (CranioCatch, Eskişehir, Turkey) and polygonal type labeling method on a total of 65 anonymous retrospective intraoral patient images of oral mucosa that were diagnosed with oral cancer histopathologically by incisional biopsy from individuals in our clinic. All images have been rechecked and verified by experienced experts. This data set was divided into training (n = 53), validation (n = 6) and test (n = 6) sets. Artificial intelligence model was developed using YOLOv5 architecture, which is a deep learning approach. Model success was evaluated with confusion matrix.

Results

When the success rate in estimating the images reserved for the test not used in education was evaluated, the F1, sensitivity and precision results of the artificial intelligence model obtained using the YOLOv5 architecture were found to be 0.667, 0.667 and 0.667, respectively.

Conclusions

Our study reveals that OCSCC lesions carry discriminative visual appearances, which can be identified by deep learning algorithm. Artificial intelligence shows promise in the prediagnosis of oral cancer lesions. The success rates will increase in the training models of the data set that will be formed with more images.
导言:口腔中的口腔鳞状细胞癌(OSCC)是牙科医生可以诊断甚至治愈的一类疾病。本研究评估了为检测口腔内回顾性患者图像中的口腔癌病灶而开发的计算机诊断软件的性能:使用 CranioCatch 标记程序(CranioCatch,Eskişehir,土耳其)和多边形标记方法对口腔癌病灶进行标记,这些病灶来自本诊所经切口活检组织病理学诊断为口腔癌的总共 65 张匿名口腔内回顾性患者图像。所有图像均由经验丰富的专家重新检查和验证。该数据集分为训练集(53 张)、验证集(6 张)和测试集(6 张)。人工智能模型采用 YOLOv5 架构开发,这是一种深度学习方法。用混淆矩阵评估了模型的成功率:在评估预留用于测试而未用于教学的图像的成功率时,发现使用 YOLOv5 架构获得的人工智能模型的 F1、灵敏度和精确度结果分别为 0.667、0.667 和 0.667:我们的研究表明,OCSCC 病变具有可辨别的视觉外观,可以通过深度学习算法进行识别。人工智能在口腔癌病变的预诊中大有可为。随着更多图像形成数据集的训练模型,成功率会越来越高。
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引用次数: 0
Policy of fourteen maxillofacial divisions towards titanium plates removal after internal fixation of paediatric maxillofacial fractures: A World Oral Maxillofacial Trauma (WORMAT) project 世界口腔颌面创伤(WORMAT)项目:世界口腔颌面创伤(WORMAT)项目。
IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101986
Giulia Cremona , Serena Paione , Fabio Roccia , Sahand Samieirad , Marko Lazíc , Vitomir S. Konstantinovic , Euan Rae , Sean Laverick , Aleš Vesnaver , Anže Birk , Luis Fernando de Oliveira Gorla , Valfrido Antonio Pereira-Filho , Emil Dediol , Boris Kos , Petia Pechalova , Angel Sapundzhiev , Kathia Dubron , Constantinus Politis , Emanuele Zavattero , Gian Battista Bottini , Federica Sobrero

Introduction

The aim of this 11-year retrospective multicentric study is to evaluate the policy of 14 maxillofacial surgery divisions in terms of titanium plate removal from paediatric patients who had undergone open reduction and internal fixation (ORIF) to treat maxillofacial fractures.

Material and methods

Patients ≤ 16 years undergoing surgical treatment for fractures of middle and lower third of the face between January 2011 and December 2022, with a minimum follow-up of 6 months, were included. Age (group A: ≤ 6 years, B: 7–12 years, C: 13–16 years), sex, fracture location and type, surgical approach, number, and location of positioned and removed plates, timing and indications for removal were recorded.

Results

191/383 (50 %) patients (median age, 10 years; M:F ratio 2.1:1) underwent removal of 319/708 (45 %) plates. Maxillary dentoalveolar process (91 %), angle/ramus (63 %) and mandibular body (61 %) had a significantly higher removal rate than other fracture sites (p < 0.001). A significant decreasing trend in removal with increasing age was observed, from 83 % in Group A to 24 % in Group C (p < 0.001). On the total of positioned plates, 11 % were removed for symptomatic reasons (5 % infections, 6 % discomfort/pain) and 34 % for other reasons (28 % scheduled removal).

Discussion

This multicentric study showed that plate removal was not performed routinely in the paediatric population. The incidence and causes of symptomatic plates removal were consistent with the literature, while the plate removal rate from asymptomatic patients was lower. A correlation was found between increasing age and a reduction in the frequency of plate removal procedures.
导言:这项为期11年的多中心回顾性研究旨在评估14个颌面外科部门在对接受开放复位内固定术(ORIF)治疗颌面部骨折的儿童患者进行钛板取出方面的政策:纳入2011年1月至2022年12月期间因面部中下1/3骨折接受手术治疗且随访至少6个月的16岁以下患者。研究记录了患者的年龄(A组:≤6岁;B组:7-12岁;C组:13-16岁)、性别、骨折部位和类型、手术方式、定位钢板和移除钢板的数量和位置、移除钢板的时间和适应症:191/383(50%)名患者(中位年龄为 10 岁;男女比例为 2.1:1)接受了 319/708 (45%)块钢板的移除手术。上颌牙槽突(91%)、角/ramus(63%)和下颌体(61%)的钢板取出率明显高于其他骨折部位(讨论:这项多中心研究表明,在儿科人群中,钢板移除并非常规做法。无症状钢板移除的发生率和原因与文献报道一致,而无症状患者的钢板移除率较低。研究发现,年龄的增长与钢板移除手术频率的降低之间存在相关性。
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引用次数: 0
期刊
Journal of Stomatology Oral and Maxillofacial Surgery
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