Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Prevalence and risk factors of cleft lip and/or palate in Ethiopia: A systematic review and meta-analysis","authors":"Mandefrogn Mammo Lemma ,&nbsp;Firehiwot Gezahegn Abebe ,&nbsp;Estifanos Esubalew Lewogineh","doi":"10.1016/j.jormas.2026.102712","DOIUrl":"10.1016/j.jormas.2026.102712","url":null,"abstract":"<div><h3>Background</h3><div>Cleft lip and/or palate (CL/P) is the most common congenital orofacial anomalies worldwide, with a multifactorial etiology involving both genetic and environmental factors. This study aimed to estimate the pooled prevalence of CL/P in Ethiopia and identify the associated risk factors.</div></div><div><h3>Materials and Methods</h3><div>We systematically searched PubMed, Scopus, and Google Scholar for studies published between 1990 and 2023. We included observational studies (cross-sectional, cohort, case–control, descriptive, and prospective) that reported prevalence data for CL/P in Ethiopia. Data were extracted using a standardized Excel form, and statistical analyses were conducted using STATA version 18. The primary outcome was the pooled prevalence of CL/P. Heterogeneity was assessed using Cochrane’s Q test and the I² statistic, and meta-analysis was performed using a random-effects model. The methodological quality of the studies was assessed using the STROBE checklist (version 2007).</div></div><div><h3>Results</h3><div>Across ten studies comprising 19,024,539 births, the pooled birth prevalence of CL/P in Ethiopia was 0.24 per 1000 live births (95 % CI: 0.12–0.36). Considerable heterogeneity was observed among studies (I² = 99.94 %, τ² = 0.04, <em>Q</em> = 8546.85, <em>p</em> &lt; 0.001), reflecting substantial variability in prevalence estimates.</div></div><div><h3>Conclusion</h3><div>Although the prevalence of CL/P in Ethiopia is lower than the global average, it represents a significant public health concern. This underscores the need for strengthen preventive measures, promoting early detection, and expanding access to timely and comprehensive treatment services are essential for reducing the burden of these congenital anomalies.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102712"},"PeriodicalIF":2.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Squamous cell carcinoma in the lacrimal sac presenting as proptosis: a case report","authors":"Milan Martinez Sanchez ,&nbsp;Annelies Kerckhofs ,&nbsp;Elke Van de Casteele ,&nbsp;Lukas Vaes ,&nbsp;Wouter De Vos","doi":"10.1016/j.jormas.2026.102711","DOIUrl":"10.1016/j.jormas.2026.102711","url":null,"abstract":"<div><h3>Key Clinical Message</h3><div>Lacrimal sac squamous cell carcinoma is extremely rare, and treatment guidelines remain unclear. In select cases, wide en bloc resection combined with prosthetic rehabilitation may offer the best outcomes. This case report advocates a multidisciplinary, consensus-driven approach centered on patient outcomes, with the use of a 3D printed skull with the benefits of gaining insight and providing visualisation pre-operatively. In addition, we want to emphasise the importance of speed in diagnosis and treatment in this report, in order to ensure optimal care.</div></div><div><h3>Summary</h3><div>Lacrimal sac squamous cell carcinoma is a rare epithelial malignancy often misdiagnosed as chronic dacryocystitis, delaying treatment. This article reports a pT4bN2bM0 case in a 67-year-old man treated with wide en bloc resection, yielding clear margins (&gt;6 mm) and found after 4 months from initial symptoms. A 3D-printed skull model aided preoperative visualization. Histology revealed lymphovascular invasion and broad nests of atypical squamous cells with dyskeratosis and necrosis, confirming lacrimal origin. Adjuvant chemoradiotherapy followed. At 21 months follow-up, no signs of local, regional, or distant recurrence were observed.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102711"},"PeriodicalIF":2.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of bruxism in users of selective serotonin reuptake inhibitors and serotonin–norepinephrine reuptake inhibitors: A retrospective cross-sectional study","authors":"Isabela Menezes Santos ,&nbsp;Emily Vieira Machado ,&nbsp;Dhelfeson Willya Douglas de Oliveira ,&nbsp;Olga Dumont Flecha ,&nbsp;Brender Leonan-Silva","doi":"10.1016/j.jormas.2026.102710","DOIUrl":"10.1016/j.jormas.2026.102710","url":null,"abstract":"<div><h3>Introduction</h3><div>Bruxism is a repetitive jaw-muscle activity, involving teeth clenching, grinding, and mandibular bracing or thrusting, occurring during wakefulness or sleep. Its multifactorial etiology includes neurophysiological, psychosocial, and pharmacological factors. Increasing evidence suggests an association between serotonergic antidepressants—especially SSRIs and SNRIs—and the onset or worsening of bruxism. This study aims to assess bruxism prevalence among SSRI/SNRI users and explore its correlation with demographic, occupational, and psychosocial factors.</div></div><div><h3>Material and methods</h3><div>A retrospective cross-sectional analysis was conducted based on clinical records of patients treated at the Temporomandibular Disorders Clinic of the Federal University of the Jequitinhonha and Mucuri Valleys (Brazil) between 2013 and 2024. Bruxism diagnosis was based on self-report and clinical evidence of tooth wear. Because the database spans years predating the publication of the STAB consensus, standardized STAB-based diagnostic protocols could not be retrospectively applied. Data were analyzed using Pearson’s chi-square and logistic regression (α = 0.05).</div></div><div><h3>Results</h3><div>Among 583 patients evaluated, 400 (68.6%) presented signs of bruxism. Fifty-three (9.1%) were SSRI/SNRI users, of whom 43 (81.1%) exhibited bruxism. Logistic regression revealed that antidepressant users were 2.5 times more likely to present bruxism than non-users (OR = 2.52; 95% CI: 1.21–5.23; <em>p</em> = 0.014). Occupational stress, particularly among students, was also significantly associated (OR = 1.77; <em>p</em> = 0.004). Axis II–related symptoms (stress, anxiety, and depression) showed no statistical significance.</div></div><div><h3>Discussion</h3><div>The use of serotonergic antidepressants, especially SSRIs, was significantly associated with bruxism. These findings underscore the importance of considering psychopharmacological and psychosocial factors in the diagnostic and therapeutic management of bruxism.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102710"},"PeriodicalIF":2.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total lower lip and chin replantation following a trampoline accident: Rescue surgery with intensive leech therapy","authors":"V Sounthakith ,&nbsp;A Schweitzer-Chaput ,&nbsp;A Picard ,&nbsp;J Prebot ,&nbsp;A Galland ,&nbsp;C Neiva-Vaz ,&nbsp;RH Khonsari","doi":"10.1016/j.jormas.2026.102709","DOIUrl":"10.1016/j.jormas.2026.102709","url":null,"abstract":"<div><div>Lip amputations in children may require urgent microsurgical management. Here we report a salvage procedure with partial survival following lower lip and chin replantation after a trampoline accident. Total amputation was managed with inferior labial artery anastomosis; however, venous drainage was not reestablished, necessitating leech therapy. Despite arterial revisions, 75 % of the lip and 25 % of the chin were lost by post-operative day 14. Reconstruction with a combined right Karapandzic flap and left Camille Bernard flap was performed one month later, supplemented by mesotherapy and nanofat injections. The outcome was marked by residual microstomia. These injuries are rare in children, often caused by dog bites. Venous anastomosis is frequently unfeasible, with leech therapy critical for drainage. When replantation is partially successful, reconstruction may involve local flaps or free tissue transfers. Microsurgical expertise, access to leech therapy and close collaboration with intensivists are essential for optimizing outcomes.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102709"},"PeriodicalIF":2.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of mandibular defects using free fibula flaps with a spliced surgical template system","authors":"Wei Cao ,&nbsp;PengFei Zhao ,&nbsp;Zhang Zhao ,&nbsp;YiMing Chen","doi":"10.1016/j.jormas.2025.102705","DOIUrl":"10.1016/j.jormas.2025.102705","url":null,"abstract":"<div><h3>Background</h3><div>Mandibular defect reconstruction after tumor resection poses significant challenges in oral and maxillofacial surgery. The free fibula flap is widely used and effective for reconstructing such defects. Traditional manual segmentation and stabilization can lead to inaccuracies; while 3D-printed guides improve cutting precision, they often overlook the stabilization of bone segments. The conventional surgical template system consists of three separate guides: a tumor removal guide, a fibula cutting guide, and a reconstruction guide, which requires manual detachment and reshaping of fibula segments before reconstruction. In contrast, the spliced surgical template system integrates an additional fibula cutting frame and reconstruction frame. This allows the fibula cutting guides to transform directly into the reconstruction guide without detaching the segments, thereby simplifying the workflow and improving stabilization accuracy. This study evaluates a spliced surgical template system and compares its accuracy in stabilizing bone segments with that of conventional systems.</div></div><div><h3>Patient and method</h3><div>A retrospective cohort study was conducted for patients who underwent mandibular tumor resection and free fibula flap reconstruction at Shanghai Ninth People’s Hospital from 01/01/2022 to 31/03/2025. Patients were divided into two groups based on whether they used conventional or spliced surgical template systems. Preoperative virtual surgical planning was adapted to create 3D models, cutting guides, and reconstructing guides. Postoperative CT scans were also analyzed to assess reconstruction accuracy by measuring deviations in three dimensions.</div></div><div><h3>Result</h3><div>20 patients were included; 10 used the spliced surgical template system, and the rest used the conventional ones. The spliced system showed significantly more minor errors in reconstruction accuracy than the other. The offset was X-axis 0.31 [0.13, 0.97] mm, Y-axis 0.32 [0.11, 0.78] mm, and Z-axis 0.37 [0.06, 0.47] mm for the spliced system, versus 4.03 [0.61, 18.49] mm, 3.50 [0.66, 13.94] mm, and 3.14 [0.85, 7.25] mm for the conventional system, which were all statistically significant (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The spliced surgical template system provides higher accuracy and stability in mandibular reconstruction with the free fibula flap. It reduces errors in the positioning of fibula segments, resulting in improved reconstruction precision and potentially contributing to better functional outcomes compared with conventional methods.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102705"},"PeriodicalIF":2.0,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative prognostic modeling and mediation analysis of recurrence risk in extremely early-stage oral squamous cell carcinoma","authors":"Yi-quan Chen ,&nbsp;Hai-jun Wu","doi":"10.1016/j.jormas.2025.102708","DOIUrl":"10.1016/j.jormas.2025.102708","url":null,"abstract":"<div><h3>Background</h3><div>Despite complete surgical resection, recurrence remains a substantial challenge in patients with early-stage oral squamous cell carcinoma (OSSC). Conventional TNM staging does not fully capture the biological heterogeneity underlying relapse. This study aimed to develop an individualized recurrence-prediction model integrating clinicopathologic, immune, and spatial factors, and to evaluate the potential mediating role of perineural invasion (PNI).</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 451 patients with stage I–II OSCC treated at Xiangya Hospital between 2018 and 2025. Twenty-three clinical, pathological, and immunohistochemical variables were initially screened using LASSO regression. Independent predictors of recurrence were subsequently identified through multivariable Cox analysis. A nomogram was constructed based on the final Cox model and internally validated using Harrell’s C-index, time-dependent AUCs, and 1,000-bootstrap calibration. Risk stratification was performed using Kaplan–Meier curves, and mediation analysis was used to determine whether PNI mediated the effects of tumor grade, P53 status, and age on recurrence.</div></div><div><h3>Results</h3><div>Six independent predictors were incorporated into the final model: tumor grade, PNI, postoperative lymphocyte nadir, tumor-to-midline distance, pathological stage, and P53 status. The model demonstrated good discrimination (C-index = 0.79) and strong time-dependent predictive accuracy (AUCs: 0.819, 0.825, and 0.807 at 1, 3, and 5 years, respectively). Calibration curves showed excellent agreement between predicted and observed recurrence probabilities. Risk stratification based on the nomogram clearly separated patients into low- and high-risk groups (log-rank p &lt; 0.001). Mediation analysis showed that PNI partially mediated the effects of tumor grade (proportion mediated = 29.6%) and P53 status (7.7%) on recurrence, whereas age exhibited no significant mediation through PNI.</div></div><div><h3>Conclusions</h3><div>This integrated prognostic model combines immune recovery, spatial invasion, and molecular features to accurately predict recurrence in early-stage OSCC. The partial mediation of tumor aggressiveness through PNI highlights a biological pathway linking tumor phenotype to recurrence risk. The proposed nomogram provides a clinically applicable tool for postoperative risk stratification and may assist in tailoring surveillance strategies and individualized adjuvant treatment decisions.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102708"},"PeriodicalIF":2.0,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and biomechanical evaluation of subject-specific, anatomically complete 3D finite element models of the temporomandibular joint using the four-finger mouth-opening test","authors":"Ananta Jain ,&nbsp;Rashmi Uddanwadikar ,&nbsp;Sunita Shrivastav","doi":"10.1016/j.jormas.2025.102706","DOIUrl":"10.1016/j.jormas.2025.102706","url":null,"abstract":"<div><h3>Background</h3><div>Accurate biomechanical characterization of asymptomatic TMJ function requires anatomically complete, subject-specific models, yet such validated finite element (FE) frameworks remain limited.</div></div><div><h3>Objective</h3><div>To introduce and technically evaluate a novel MRI-validated, kinematically -driven, anatomically complete, subject-specific 3D nonlinear FE TMJ framework, and to demonstrate its biomechanical responses in one asymptomatic subject and two Class II cases with mild and moderate anterior disc displacement during the four-finger mouth-opening test.</div></div><div><h3>Methods</h3><div>Three subject-specific TMJ models were constructed using CBCT for hard tissues and high-resolution MRI for soft tissues. A hybrid anatomical workflow integrating 3D Slicer, Blender, and ANSYS SpaceClaim enabled complete maxillofacial reconstruction. Nonlinear FE simulations (ANSYS Workbench) quantified stresses in the disc, condylar head, condylar neck, articular eminence, and glenoid fossa using validated material properties, frictional contacts, and physiological kinematic loading derived from motion-capture trajectories.</div></div><div><h3>Results</h3><div>MRI-based geometric and kinematic validation showed &lt;5% error in disc rotational angle and condylar translation. In the asymptomatic subject, compressive stresses occurred in intermediate disc regions, with tensile stresses near anterior and posterior attachments. The mild displacement case showed elevated posterior disc and anterior condylar stresses, while the moderate case exhibited the highest disc, condylar head, and neck stresses 0.637 MPa and 1.40 MPa, respectively. Across all three individuals, maximum stresses occurred as the condyle advanced over the articular eminence.</div></div><div><h3>Conclusion</h3><div>This feasibility study introduces a validated, anatomically complete subject-specific FE TMJ model that captures rotation–translation in the asymptomatic case and restricted translation with elevated stresses in mild and moderate displacement, supporting future expansion.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102706"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of the mental foramen as a guide for marginal mandibulectomy in oral squamous cell carcinoma patients with tumor-free margins: experience of 15 years","authors":"Luz Walker ,&nbsp;Matthias Schlund ,&nbsp;Claire Majoufre ,&nbsp;Justine Duvernay","doi":"10.1016/j.jormas.2025.102701","DOIUrl":"10.1016/j.jormas.2025.102701","url":null,"abstract":"<div><h3>Background</h3><div>Preserving an adequate residual mandibular height during marginal mandibulectomy is essential to reduce the risk of postoperative fracture while maintaining oncologic safety in patients with oral squamous cell carcinoma (OSCC).</div></div><div><h3>Purpose</h3><div>The aim of this study was to evaluate the oncologic outcomes of marginal mandibulectomy guided by the mental foramen and to assess its relevance as an anatomical landmark for osteotomy.</div></div><div><h3>Material and methods</h3><div>Patients treated for OSCC by marginal mandibulectomy with localization of the mental foramen between 2007 and 2022 were retrospectively included. The primary endpoint was bone resection margin status. Secondary endpoints included local recurrence-free survival, disease-free survival, and overall survival. An anatomical analysis of the mental foramen position relative to the inferior osteotomy line was performed using postoperative computed tomography.</div></div><div><h3>Results</h3><div>A total of 150 patients met all inclusion criteria. Clear bone margins (R0) were achieved in 98 % of cases. Bone invasion (pT4) was observed in 41.3 % of patients. At 5 years, local recurrence-free survival, disease-free survival, and overall survival were consistent with outcomes reported for selected OSCC treated by marginal mandibulectomy. No immediate postoperative mandibular fractures were observed. The inferior osteotomy line showed a consistent relationship with the mental foramen.</div></div><div><h3>Conclusion</h3><div>Marginal mandibulectomy guided by the mental foramen allows reproducible bone resection while achieving satisfactory oncologic outcomes. The mental foramen constitutes a reliable anatomical landmark for osteotomy in carefully selected patients with OSCC.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102701"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflections on the use of ChatGPT in oral and maxillofacial surgery","authors":"Jiayi Chen","doi":"10.1016/j.jormas.2025.102707","DOIUrl":"10.1016/j.jormas.2025.102707","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102707"},"PeriodicalIF":2.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curved tip discopexy as a modification to enhance the suture grasping in TMJ arthroscopy","authors":"Rodriguez-Saenz Alvaro ,&nbsp;Diego Mauricio Rodriguez-Saenz ,&nbsp;Juan Pablo López","doi":"10.1016/j.jormas.2025.102702","DOIUrl":"10.1016/j.jormas.2025.102702","url":null,"abstract":"<div><div>Temporomandibular joint discopexy techniques performed by arthroscopy have undergone multiple modifications to reduce the learning curve. Multiple modifications have been made to the technique and instruments; however, discopexy remains challenging due to the difficulty in suture capture. The curved technique leaves the suture in a more comfortable position for capturing the suture with the forceps in a simple way, facilitating the procedure and reducing surgical times without the need for special equipment.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102702"},"PeriodicalIF":2.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}