Pub Date : 2025-12-31DOI: 10.1016/j.jormas.2025.102702
Rodriguez-Saenz Alvaro , Diego Mauricio Rodriguez-Saenz , Juan Pablo López
Temporomandibular joint discopexy techniques performed by arthroscopy have undergone multiple modifications to reduce the learning curve. Multiple modifications have been made to the technique and instruments; however, discopexy remains challenging due to the difficulty in suture capture. The curved technique leaves the suture in a more comfortable position for capturing the suture with the forceps in a simple way, facilitating the procedure and reducing surgical times without the need for special equipment.
{"title":"Curved tip discopexy as a modification to enhance the suture grasping in TMJ arthroscopy","authors":"Rodriguez-Saenz Alvaro , Diego Mauricio Rodriguez-Saenz , Juan Pablo López","doi":"10.1016/j.jormas.2025.102702","DOIUrl":"10.1016/j.jormas.2025.102702","url":null,"abstract":"<div><div>Temporomandibular joint discopexy techniques performed by arthroscopy have undergone multiple modifications to reduce the learning curve. Multiple modifications have been made to the technique and instruments; however, discopexy remains challenging due to the difficulty in suture capture. The curved technique leaves the suture in a more comfortable position for capturing the suture with the forceps in a simple way, facilitating the procedure and reducing surgical times without the need for special equipment.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102702"},"PeriodicalIF":2.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The trigeminocardiac reflex is a clinically important autonomic response to trigeminal stimulation, particularly characterized by heart rate reduction; however, its behavior under local anesthesia is not well defined. This prospective clinical study investigated the impact of different local anesthesia techniques on the incidence and hemodynamic characteristics of the trigeminocardiac reflex (TCR) during mandibular nerve stimulation in awake patients.
Materials and Methods
Forty individuals undergoing surgical extraction of impacted mandibular teeth were enrolled. To minimize vasovagal influence, anxious patients were excluded. Group-1 received a Gow-Gates mandibular nerve block, whereas Group-2 received an inferior alveolar nerve block with supplementary buccal anesthesia. Heart rate (HR) and mean arterial blood pressure (MABP) were continuously monitored throughout local anesthesia administration and all surgical stages.
Results
TCR-compatible bradycardia occurred in 30% (12/40) of patients, most frequently during anesthetic injection and mucosal manipulation, including flap elevation, and suturing.A significantly higher incidence of the TCR was observed in Group 1.The maximum HR reduction recorded was 43.5%. The linear progression of stage-specific baseline MABP and HR values showed a significant decrease during curettage/irrigation and suturing.
Conclusion
These findings demonstrate that the TCR can occur during oral surgery performed under local anesthesia, typically at mild levels, and that the anesthesia technique influences its incidence. This study contributes to the current literature by evaluating the prophylactic potential of different local anesthesia techniques in oral surgery and by integrating anxiety assessment to enhance methodological robustness.
{"title":"Role of anesthetic techniques in trigeminocardiac reflex during oral surgery of the mandible under local anesthesia","authors":"Bedreddin Cavlı , Aykut Şaylığ , Şeyma Kale , Necmiye Şengel , Ziver Ergun Yücel","doi":"10.1016/j.jormas.2025.102704","DOIUrl":"10.1016/j.jormas.2025.102704","url":null,"abstract":"<div><h3>İntroduction</h3><div>The trigeminocardiac reflex is a clinically important autonomic response to trigeminal stimulation, particularly characterized by heart rate reduction; however, its behavior under local anesthesia is not well defined. This prospective clinical study investigated the impact of different local anesthesia techniques on the incidence and hemodynamic characteristics of the trigeminocardiac reflex (TCR) during mandibular nerve stimulation in awake patients.</div></div><div><h3>Materials and Methods</h3><div>Forty individuals undergoing surgical extraction of impacted mandibular teeth were enrolled. To minimize vasovagal influence, anxious patients were excluded. Group-1 received a Gow-Gates mandibular nerve block, whereas Group-2 received an inferior alveolar nerve block with supplementary buccal anesthesia. Heart rate (HR) and mean arterial blood pressure (MABP) were continuously monitored throughout local anesthesia administration and all surgical stages.</div></div><div><h3>Results</h3><div>TCR-compatible bradycardia occurred in 30% (12/40) of patients, most frequently during anesthetic injection and mucosal manipulation, including flap elevation, and suturing.A significantly higher incidence of the TCR was observed in Group 1.The maximum HR reduction recorded was 43.5%. The linear progression of stage-specific baseline MABP and HR values showed a significant decrease during curettage/irrigation and suturing.</div></div><div><h3>Conclusion</h3><div>These findings demonstrate that the TCR can occur during oral surgery performed under local anesthesia, typically at mild levels, and that the anesthesia technique influences its incidence. This study contributes to the current literature by evaluating the prophylactic potential of different local anesthesia techniques in oral surgery and by integrating anxiety assessment to enhance methodological robustness.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102704"},"PeriodicalIF":2.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-31DOI: 10.1016/j.jormas.2025.102700
Yao Li , Ke Liu , Yifan Lu , Min Gan
Objective
To investigate vascular endothelial growth factor (VEGF) mRNA expression as an independent biomarker for predicting recurrence in ameloblastoma (AM), and to evaluate its potential for guiding surgical strategy.
Methods
A retrospective cohort study was conducted involving 200 patients with primary AM undergoing initial surgery during January 2021-December 2023. Patients were categorized into curettage (n = 77) and extended resection (n = 123) groups. Relative VEGF mRNA expression in the tumor cyst wall was quantified using RT-qPCR. Kaplan-Meier analysis and Cox regression were used to analyze recurrence-free survival (RFS) and risk factors. Perioperative outcomes and complications were compared between groups. Univariate and multivariate analyses were performed using Cox proportional hazards regression models.
Results
VEGF mRNA expression was significantly elevated in the recurrence group (4.66 ± 1.42) versus the non-recurrence group (3.24 ± 2.02, P < 0.001). ROC curve analysis identified an optimal VEGF cutoff value of 4.88 for predicting recurrence (AUC = 0.694). This molecular stratification revealed a profound disparity: the 2-year RFS was significantly lower in the VEGF-high group (77.4 %) compared to the VEGF-low group (94.9 %, P < 0.001). While extended resection provided a higher 2-year RFS than curettage (96.0 % vs. 79.5 %, P < 0.001), it incurred greater operative burden and complication risks. Crucially, multivariate analysis established high VEGF expression as the most powerful independent predictor of recurrence (HR = 45.15, P < 0.001), with a risk magnitude exceeding that of curettage (HR = 37.22, P < 0.001).
Conclusion
High VEGF mRNA expression is a powerful, independent biomarker for AM recurrence, with a prognostic impact surpassing surgical choice. Preoperative VEGF assessment holds significant potential for guiding individualized surgical planning and optimizing follow-up strategies.
{"title":"VEGF mRNA expression as a powerful independent predictor for recurrence in ameloblastoma: Integrating molecular profiling with surgical outcome analysis","authors":"Yao Li , Ke Liu , Yifan Lu , Min Gan","doi":"10.1016/j.jormas.2025.102700","DOIUrl":"10.1016/j.jormas.2025.102700","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate vascular endothelial growth factor (VEGF) mRNA expression as an independent biomarker for predicting recurrence in ameloblastoma (AM), and to evaluate its potential for guiding surgical strategy.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted involving 200 patients with primary AM undergoing initial surgery during January 2021-December 2023. Patients were categorized into curettage (<em>n</em> = 77) and extended resection (<em>n</em> = 123) groups. Relative VEGF mRNA expression in the tumor cyst wall was quantified using RT-qPCR. Kaplan-Meier analysis and Cox regression were used to analyze recurrence-free survival (RFS) and risk factors. Perioperative outcomes and complications were compared between groups. Univariate and multivariate analyses were performed using Cox proportional hazards regression models.</div></div><div><h3>Results</h3><div>VEGF mRNA expression was significantly elevated in the recurrence group (4.66 ± 1.42) versus the non-recurrence group (3.24 ± 2.02, <em>P</em> < 0.001). ROC curve analysis identified an optimal VEGF cutoff value of 4.88 for predicting recurrence (AUC = 0.694). This molecular stratification revealed a profound disparity: the 2-year RFS was significantly lower in the VEGF-high group (77.4 %) compared to the VEGF-low group (94.9 %, <em>P</em> < 0.001). While extended resection provided a higher 2-year RFS than curettage (96.0 % vs. 79.5 %, <em>P</em> < 0.001), it incurred greater operative burden and complication risks. Crucially, multivariate analysis established high VEGF expression as the most powerful independent predictor of recurrence (HR = 45.15, <em>P</em> < 0.001), with a risk magnitude exceeding that of curettage (HR = 37.22, <em>P</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>High VEGF mRNA expression is a powerful, independent biomarker for AM recurrence, with a prognostic impact surpassing surgical choice. Preoperative VEGF assessment holds significant potential for guiding individualized surgical planning and optimizing follow-up strategies.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102700"},"PeriodicalIF":2.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30DOI: 10.1016/j.jormas.2025.102699
A.I. Yakubu , M. Bala , R.O. Braimah , A. Bello , A. Abubakar , A.T. Bakare , H.T. Ismail , I. Abdulfattah , I.O. Bruno , B.A. Sulaiman , J. Sarki , I.A. Hadi , Z. Umar , A.S. Inuwa , A.Y. Abbas , M.I. Gidado , A.A. Bioku , A. Abdullahi , U. Abdullahi , A.O. Taiwo
Background
Cancrum Oris is a devastating gangrenous lesion of the orofacial regions that primarily affects the undernourished children, with consequent disfigurement of the face. Noma places a considerable social, psychological, emotional, and financial burden on their informal caregivers. However, this burden on caregivers remains largely understudied. This research aimed to assess the level and predictors of caregiver psychological burden among informal caregivers of Noma patients in Northwestern Nigeria.
Materials and methods
This was a cross-sectional study conducted among 92 informal caregivers of Noma survivors attending Noma Children’s Hospital in Sokoto, who were recruited via a universal sampling method over two years. Caregiver burden was assessed using the Zarit Burden Interview (ZBI). Data were analyzed using SPSS version 25, with Chi-square tests employed to determine associations and logistic regression used to identify predictors. Statistical significance was set at p < 0.05.
Results
The mean age of the caregivers was 38.0 years (SD ± 10.1); most were female (84.8%), married (87.0%), and parents of the survivor. The caregivers experienced a mild-to-moderate burden in 47.8% of cases, a moderate-to-severe burden in 47.8%, and a severe burden in 4.4%. Being female (p = 0.0170) and being a parent (p = 0.011) were associated with higher caregiver burden; female sex remained the only independent predictor of high caregiver burden (p = 0.019).
Conclusion
Informal caregivers of Noma survivors experience considerable psychological burden, particularly female caregivers and parents of patients. Targeted psychosocial support is necessary to alleviate caregiver strain and enhance care outcomes.
{"title":"Magnitude and predictors of psychological burden of care among informal caregivers of Noma survivors","authors":"A.I. Yakubu , M. Bala , R.O. Braimah , A. Bello , A. Abubakar , A.T. Bakare , H.T. Ismail , I. Abdulfattah , I.O. Bruno , B.A. Sulaiman , J. Sarki , I.A. Hadi , Z. Umar , A.S. Inuwa , A.Y. Abbas , M.I. Gidado , A.A. Bioku , A. Abdullahi , U. Abdullahi , A.O. Taiwo","doi":"10.1016/j.jormas.2025.102699","DOIUrl":"10.1016/j.jormas.2025.102699","url":null,"abstract":"<div><h3>Background</h3><div>Cancrum Oris is a devastating gangrenous lesion of the orofacial regions that primarily affects the undernourished children, with consequent disfigurement of the face. Noma places a considerable social, psychological, emotional, and financial burden on their informal caregivers. However, this burden on caregivers remains largely understudied. This research aimed to assess the level and predictors of caregiver psychological burden among informal caregivers of Noma patients in Northwestern Nigeria.</div></div><div><h3>Materials and methods</h3><div>This was a cross-sectional study conducted among 92 informal caregivers of Noma survivors attending Noma Children’s Hospital in Sokoto, who were recruited via a universal sampling method over two years<strong>.</strong> Caregiver burden was assessed using the Zarit Burden Interview (ZBI)<strong>.</strong> Data were analyzed using SPSS version 25, with Chi-square tests employed to determine associations and logistic regression used to identify predictors. Statistical significance was set at <em>p</em> < 0.05.</div></div><div><h3>Results</h3><div>The mean age of the caregivers was 38.0 years (SD ± 10.1)<strong>;</strong> most were female (84.8%)<strong>,</strong> married (87.0%)<strong>,</strong> and parents of the survivor. The caregivers experienced a mild-to-moderate burden in 47.8% of cases, a moderate-to-severe burden in 47.8%, and a severe burden in 4.4%. Being female (<em>p</em> = 0.0170) and being a parent (<em>p</em> = 0.011) were associated with higher caregiver burden; female sex remained the only independent predictor of high caregiver burden <strong>(</strong><em>p</em> = 0.019)<strong>.</strong></div></div><div><h3>Conclusion</h3><div>Informal caregivers of Noma survivors experience considerable psychological burden, particularly female caregivers and parents of patients. Targeted psychosocial support is necessary to alleviate caregiver strain and enhance care outcomes.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102699"},"PeriodicalIF":2.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30DOI: 10.1016/j.jormas.2025.102703
Nitya Krishnasamy , Hema Shree K
Introduction
Oral squamous cell carcinoma (OSCC) is a major global health burden, traditionally associated with tobacco, alcohol, and betel quid. In recent years, however, cases have emerged among individuals without these classic risk factors. Chronic exposure to electromagnetic fields (EMFs) from mobile phones and wireless devices has been classified as possibly carcinogenic, yet its potential role in oral carcinogenesis has not been systematically studied.
Technical Note
This article highlights the biological plausibility that prolonged, localized EMF exposure may contribute to DNA damage, oxidative stress, and epigenetic modifications in oral epithelial tissues. Evidence from pilot cytogenetic studies, in vitro models, and limited epidemiological data observed increased micronucleus frequency and altered cellular stress responses in buccal mucosal cells of long-term mobile phone users. While direct causal data in OSCC remain absent, these findings suggest that EMFs could act alone or in synergy with established carcinogens.
Discussion
The technical note underscores the urgent need for in vitro, in vivo, and epidemiological studies to evaluate whether chronic EMF exposure contributes to oral carcinogenesis. Recognizing this hypothesis is not alarmist but rather a call for rigorous and unbiased investigation. If validated, such evidence could inform preventive guidelines and public health policy for emerging exposures.
{"title":"Is it time to reconsider chronic electromagnetic field exposure as a possible risk factor in oral cancer?","authors":"Nitya Krishnasamy , Hema Shree K","doi":"10.1016/j.jormas.2025.102703","DOIUrl":"10.1016/j.jormas.2025.102703","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral squamous cell carcinoma (OSCC) is a major global health burden, traditionally associated with tobacco, alcohol, and betel quid. In recent years, however, cases have emerged among individuals without these classic risk factors. Chronic exposure to electromagnetic fields (EMFs) from mobile phones and wireless devices has been classified as possibly carcinogenic, yet its potential role in oral carcinogenesis has not been systematically studied.</div></div><div><h3>Technical Note</h3><div>This article highlights the biological plausibility that prolonged, localized EMF exposure may contribute to DNA damage, oxidative stress, and epigenetic modifications in oral epithelial tissues. Evidence from pilot cytogenetic studies, <em>in vitro</em> models, and limited epidemiological data observed increased micronucleus frequency and altered cellular stress responses in buccal mucosal cells of long-term mobile phone users. While direct causal data in OSCC remain absent, these findings suggest that EMFs could act alone or in synergy with established carcinogens.</div></div><div><h3>Discussion</h3><div>The technical note underscores the urgent need for <em>in vitro, in vivo</em>, and epidemiological studies to evaluate whether chronic EMF exposure contributes to oral carcinogenesis. Recognizing this hypothesis is not alarmist but rather a call for rigorous and unbiased investigation. If validated, such evidence could inform preventive guidelines and public health policy for emerging exposures.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102703"},"PeriodicalIF":2.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-26DOI: 10.1016/j.jormas.2025.102697
Jiaqin Wang , Dingfa Gu , Fei Sun
Objective
This study aimed to compare the outcomes of immediate versus delayed implant placement in patients with periodontitis through a meta-analysis, evaluating differences in restorative outcomes, implant success rate and aesthetics.
Methods
A systematic search was conducted across multiple databases (PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure) for relevant randomised controlled trials (RCTs). The inclusion criteria identified patients with severe periodontitis with residual alveolar bone height ≥4 mm post-extraction. Nine RCTs were included, analysing the postoperative probing depth (PD), modified sulcus bleeding index (mSBI), modified plaque index (mPLI), aesthetic outcomes and implant success rate.
Results
Postoperative PD: Immediate implantation had significantly higher PD scores than delayed implantation (mean difference [MD] = 0.32, 95% confidence interval [CI] = 0.21–0.43, p < 0.0001). Postoperative mSBI: Immediate implantation showed superior mSBI scores (MD = 0.29, 95% CI = 0.12–0.46, p = 0.001). Postoperative mPLI: Immediate implantation outperformed delayed implantation (MD = 0.61, 95% CI = 0.53–0.69, p < 0.0001). Aesthetic outcomes: Immediate implantation resulted in better aesthetic scores at 3, 6 and 12 months (3 months: MD = 1.80, p < 0.0001; 6 months: MD = 2.42, p = 0.03; 12 months: MD = 1.65, p = 0.04). Implant Success Rate: A significant difference was found in implant success rates between the groups (risk ratio = 1.74, 95% CI = 1.30–2.34, p = 0.0002).
Conclusion
Immediate implantation shows significant short-term benefits in patients with periodontitis, particularly in restorative outcomes and aesthetics. Although there is no significant difference in implant success rates, delayed implantation may aid in periodontal tissue recovery. The choice between the two strategies should be tailored to the patient's condition and clinical needs.
目的：本研究旨在通过荟萃分析比较牙周炎患者即刻与延迟种植的结果，评估修复结果、种植成功率和美观性的差异。方法：系统检索多个数据库（PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure）中相关的随机对照试验（RCTs）。纳入标准为拔牙后牙槽骨残余高度≥4mm的严重牙周炎患者。纳入9项随机对照试验，分析术后探查深度（PD）、改良沟出血指数（mSBI）、改良斑块指数（mPLI）、美学结果和种植体成功率。结果：术后PD：即刻种植的PD评分明显高于延迟种植（平均差异[MD] = 0.32,95%可信区间[CI] = 0.21-0.43,p < 0.0001）。术后mSBI：即刻植入术mSBI评分较高（MD = 0.29,95% CI = 0.12-0.46,p = 0.001）。术后mPLI：即刻种植优于延迟种植（MD = 0.61,95% CI = 0.53-0.69,p < 0.0001）。审美结果:直接植入导致更好的审美得分在3、6和12个月(3个月:MD = 1.80,p < 0.0001; 6个月:MD = 2.42,p = 0.03;12个月:MD = 1.65,p = 0.04)。种植成功率：两组种植成功率差异有统计学意义（风险比 = 1.74,95% CI = 1.30-2.34,p = 0.0002）。结论：即刻种植对牙周炎患者有显著的短期效益，特别是在修复效果和美观方面。虽然种植成功率没有显著差异，但延迟种植可能有助于牙周组织的恢复。这两种策略之间的选择应根据患者的病情和临床需要而定。
{"title":"Meta-analysis comparing the outcomes of immediate versus delayed implant placement under periodontitis conditions","authors":"Jiaqin Wang , Dingfa Gu , Fei Sun","doi":"10.1016/j.jormas.2025.102697","DOIUrl":"10.1016/j.jormas.2025.102697","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to compare the outcomes of immediate versus delayed implant placement in patients with periodontitis through a meta-analysis, evaluating differences in restorative outcomes, implant success rate and aesthetics.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across multiple databases (PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure) for relevant randomised controlled trials (RCTs). The inclusion criteria identified patients with severe periodontitis with residual alveolar bone height ≥4 mm post-extraction. Nine RCTs were included, analysing the postoperative probing depth (PD), modified sulcus bleeding index (mSBI), modified plaque index (mPLI), aesthetic outcomes and implant success rate.</div></div><div><h3>Results</h3><div>Postoperative PD: Immediate implantation had significantly higher PD scores than delayed implantation (mean difference [MD] = 0.32, 95% confidence interval [CI] = 0.21–0.43, <em>p</em> < 0.0001). Postoperative mSBI: Immediate implantation showed superior mSBI scores (MD = 0.29, 95% CI = 0.12–0.46, <em>p</em> = 0.001). Postoperative mPLI: Immediate implantation outperformed delayed implantation (MD = 0.61, 95% CI = 0.53–0.69, <em>p</em> < 0.0001). Aesthetic outcomes: Immediate implantation resulted in better aesthetic scores at 3, 6 and 12 months (3 months: MD = 1.80, <em>p</em> < 0.0001; 6 months: MD = 2.42, <em>p</em> = 0.03; 12 months: MD = 1.65, <em>p</em> = 0.04). Implant Success Rate: A significant difference was found in implant success rates between the groups (risk ratio = 1.74, 95% CI = 1.30–2.34, <em>p</em> = 0.0002).</div></div><div><h3>Conclusion</h3><div>Immediate implantation shows significant short-term benefits in patients with periodontitis, particularly in restorative outcomes and aesthetics. Although there is no significant difference in implant success rates, delayed implantation may aid in periodontal tissue recovery. The choice between the two strategies should be tailored to the patient's condition and clinical needs.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102697"},"PeriodicalIF":2.0,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-26DOI: 10.1016/j.jormas.2025.102698
Ntombizodwa P. Zwane , Isak J. van der Walt , Steve A.S. Olorunju , Euphemia Sekati , Adam Shnier , Deran Reddy
Objective
: This study assessed the effect of cold atmospheric plasma (CAP) using argon and oxygen on Candida albicans biofilm growth on titanium.
Methods
: Titanium disks were treated with CAP at 10 and 20 min exposure using argon or oxygen plasma. Typical growth from an unspecified clinical Isolate Test Group (TG) (n = 8 for colony forming culture method, n = 8 for biofilm forming method) and resistant (ATCC 10,231) strain Positive Control (PC) (n = 8 for colony forming culture method, n = 8 for biofilm forming method) were tested. Negative Control (NC) was used, which involved plasma-untreated titanium plates (n = 2 for colony-forming culture method, n = 2 for biofilm-forming method). Colony-forming units (CFU) were counted, inactivation rates calculated, and biofilm quantified using optical density at 495 nm (OD495). ANOVA and two-sample tests were applied.
Results
: Oxygen plasma achieved 100% inactivation of TG, while argon plasma showed partial reduction. For resistant PC, oxygen plasma showed no effect, whereas argon achieved up to 99.5% inactivation. ANOVA revealed that group (TG vs PC) was the only significant factor (p = 0.011). Biofilm formation differed significantly between TG and PC (p = 0.014).
Conclusion
: CAP shows strain-specific antifungal activity against C. albicans. Oxygen plasma effectively inhibited TG but not resistant strains, while argon plasma partially reduced both. CAP may have potential as an adjunctive antifungal strategy.
目的：研究氩气和氧气冷常压等离子体（CAP）对白色念珠菌生物膜在钛上生长的影响。方法：用氩气或氧气等离子体对钛盘进行10min和20min的CAP处理。对未指定临床分离试验组（TG）（集落形成培养法n=8，生物膜形成法n=8）和耐药菌株（ATCC 10231）阳性对照（PC）（集落形成培养法n=8，生物膜形成法n=8）的典型生长进行了测试。阴性对照（NC）为未经等离子体处理的钛板（n=2为菌落形成培养法，n=2为生物膜形成法）。计算菌落形成单位（CFU），计算失活率，并使用光密度（OD495）对生物膜进行量化。采用方差分析和双样本检验。结果：氧等离子体100%灭活TG，氩等离子体部分还原TG。对于耐腐蚀PC，氧等离子体对其无影响，而氩气可达到99.5%的失活率。方差分析显示，组（TG vs PC）是唯一显著因素（p=0.011）。TG与PC的生物膜形成差异有统计学意义（p=0.014）。结论：CAP对白色念珠菌具有特异性抗真菌活性。氧等离子体对TG有抑制作用，但对抗性菌株无抑制作用，而氩等离子体对TG和抗性菌株均有部分抑制作用。CAP可能具有作为辅助抗真菌策略的潜力。
{"title":"Cold atmospheric plasma (CAP) shows strain-dependence against Candida albicans growth on titanium","authors":"Ntombizodwa P. Zwane , Isak J. van der Walt , Steve A.S. Olorunju , Euphemia Sekati , Adam Shnier , Deran Reddy","doi":"10.1016/j.jormas.2025.102698","DOIUrl":"10.1016/j.jormas.2025.102698","url":null,"abstract":"<div><h3>Objective</h3><div><strong>:</strong> This study assessed the effect of cold atmospheric plasma (CAP) using argon and oxygen on Candida albicans biofilm growth on titanium.</div></div><div><h3>Methods</h3><div><strong>:</strong> Titanium disks were treated with CAP at 10 and 20 min exposure using argon or oxygen plasma. Typical growth from an unspecified clinical Isolate Test Group (TG) (<em>n</em> = 8 for colony forming culture method, <em>n</em> = 8 for biofilm forming method) and resistant (ATCC 10,231) strain Positive Control (PC) (<em>n</em> = 8 for colony forming culture method, <em>n</em> = 8 for biofilm forming method) were tested. Negative Control (NC) was used, which involved plasma-untreated titanium plates (<em>n</em> = 2 for colony-forming culture method, <em>n</em> = 2 for biofilm-forming method). Colony-forming units (CFU) were counted, inactivation rates calculated, and biofilm quantified using optical density at 495 nm (OD495). ANOVA and two-sample tests were applied.</div></div><div><h3>Results</h3><div><strong>:</strong> Oxygen plasma achieved 100% inactivation of TG, while argon plasma showed partial reduction. For resistant PC, oxygen plasma showed no effect, whereas argon achieved up to 99.5% inactivation. ANOVA revealed that group (TG vs PC) was the only significant factor (<em>p</em> = 0.011). Biofilm formation differed significantly between TG and PC (<em>p</em> = 0.014).</div></div><div><h3>Conclusion</h3><div><strong>:</strong> CAP shows strain-specific antifungal activity against C. albicans. Oxygen plasma effectively inhibited TG but not resistant strains, while argon plasma partially reduced both. CAP may have potential as an adjunctive antifungal strategy.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102698"},"PeriodicalIF":2.0,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-26DOI: 10.1016/j.jormas.2025.102696
Guanglian Yang, Linkai Deng
Objective
To evaluate the impact of early postoperative occlusal intervention on mandibular border movement and functional recovery in patients with maxillofacial trauma and malocclusion.
Methods
In this retrospective 1:1 matched study, 184 patients treated during December 2019 to December 2023 were allocated to intervention (n = 92) and control (n = 92) groups. Controls received conventional postoperative care. The intervention group received additional systematic occlusal intervention initiated within one week post-surgery, comprising intermaxillary traction, occlusal splint therapy, and targeted occlusal training. Outcomes assessed included the mandibular border movement index (MBMI), Visual Analogue Scale (VAS), pressure pain threshold (PPT), Jaw Functional Limitation Scale (JFLS), and Oral Health Impact Profile-5 (OHIP-5). Complications were also recorded.
Results
At 3 months, both groups showed significant improvement in all MBMI parameters (maximum mouth opening, protrusion, lateral excursions) and the composite score, with the intervention group demonstrating superior outcomes (P < 0.05). The intervention group also exhibited significantly greater reductions in VAS scores and greater increases in PPT (P < 0.05). Similarly, significantly greater improvements were observed in the intervention group for all JFLS domains (mastication, vertical mobility, emotional/verbal expression) and OHIP-5 items, along with their total scores (P < 0.05). The complication rate did not differ significantly between groups (P > 0.05).
Conclusion
Early systematic occlusal intervention effectively promotes mandibular border movement recovery, alleviates orofacial pain, and enhances jaw function and oral health-related quality of life in patients with maxillofacial trauma and malocclusion, without increasing complication risks, representing a safe and effective adjunctive treatment strategy.
{"title":"Early postoperative occlusal intervention in patients with maxillofacial trauma and malocclusion: Impact on mandibular function recovery","authors":"Guanglian Yang, Linkai Deng","doi":"10.1016/j.jormas.2025.102696","DOIUrl":"10.1016/j.jormas.2025.102696","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of early postoperative occlusal intervention on mandibular border movement and functional recovery in patients with maxillofacial trauma and malocclusion.</div></div><div><h3>Methods</h3><div>In this retrospective 1:1 matched study, 184 patients treated during December 2019 to December 2023 were allocated to intervention (<em>n</em> = 92) and control (<em>n</em> = 92) groups. Controls received conventional postoperative care. The intervention group received additional systematic occlusal intervention initiated within one week post-surgery, comprising intermaxillary traction, occlusal splint therapy, and targeted occlusal training. Outcomes assessed included the mandibular border movement index (MBMI), Visual Analogue Scale (VAS), pressure pain threshold (PPT), Jaw Functional Limitation Scale (JFLS), and Oral Health Impact Profile-5 (OHIP-5). Complications were also recorded.</div></div><div><h3>Results</h3><div>At 3 months, both groups showed significant improvement in all MBMI parameters (maximum mouth opening, protrusion, lateral excursions) and the composite score, with the intervention group demonstrating superior outcomes (<em>P</em> < 0.05). The intervention group also exhibited significantly greater reductions in VAS scores and greater increases in PPT (<em>P</em> < 0.05). Similarly, significantly greater improvements were observed in the intervention group for all JFLS domains (mastication, vertical mobility, emotional/verbal expression) and OHIP-5 items, along with their total scores (<em>P</em> < 0.05). The complication rate did not differ significantly between groups (<em>P</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>Early systematic occlusal intervention effectively promotes mandibular border movement recovery, alleviates orofacial pain, and enhances jaw function and oral health-related quality of life in patients with maxillofacial trauma and malocclusion, without increasing complication risks, representing a safe and effective adjunctive treatment strategy.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102696"},"PeriodicalIF":2.0,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.jormas.2025.102695
Moisés Willian Aparecido Gonçalves , Iara Vieira Ferreira , Reydson Alcides de Lima-Souza , Guilherme Arruda Vieira , Marcelo Elias Schempf Cattan , Natália Vital Gonçalves , Carlos Takahiro Chone , Alfio José Tincani , Arthur Antolini-Tavares , Erika Said Abu Egal , Albina Altemani , Fernanda Viviane Mariano
Background
This systematic review aimed to summarize the clinicopathological characteristics, molecular profile, treatment, and outcomes of head and neck spindle cell carcinoma (HNSpCC).
Methods
A comprehensive search was performed in five databases and gray literature (December 2024). Associations between clinical variables were tested using Fisher’s exact and Chi-square tests, and survival was analyzed with the Kaplan-Meier method.
Results
Thirty-nine studies reporting 2,250 cases were included. HNSpCC primarily affects adult males, with the larynx being the most common site, followed by the oral cavity and oropharynx, often presenting as polypoid/exophytic tumors. Diagnosis requires careful use of immunohistochemistry, especially vimentin and epithelial markers. Genetic alterations included TP53, EGFR, ALK, and PIK3CA mutations. Surgery was the main treatment; however, local recurrences, regional and distant metastases were frequent. Survival outcomes were influenced by tumor site, stage, and recurrence. Oral cavity tumors showed the worst prognosis, while laryngeal tumors had comparatively better survival.
Conclusions
HNSpCC is an aggressive malignancy with poor outcomes, especially in advanced-stage and oral cavity cases.
{"title":"Clinicopathological analysis and survival outcomes of head and neck spindle cell carcinoma: A systematic review","authors":"Moisés Willian Aparecido Gonçalves , Iara Vieira Ferreira , Reydson Alcides de Lima-Souza , Guilherme Arruda Vieira , Marcelo Elias Schempf Cattan , Natália Vital Gonçalves , Carlos Takahiro Chone , Alfio José Tincani , Arthur Antolini-Tavares , Erika Said Abu Egal , Albina Altemani , Fernanda Viviane Mariano","doi":"10.1016/j.jormas.2025.102695","DOIUrl":"10.1016/j.jormas.2025.102695","url":null,"abstract":"<div><h3>Background</h3><div>This systematic review aimed to summarize the clinicopathological characteristics, molecular profile, treatment, and outcomes of head and neck spindle cell carcinoma (HNSpCC).</div></div><div><h3>Methods</h3><div>A comprehensive search was performed in five databases and gray literature (December 2024). Associations between clinical variables were tested using Fisher’s exact and Chi-square tests, and survival was analyzed with the Kaplan-Meier method.</div></div><div><h3>Results</h3><div>Thirty-nine studies reporting 2,250 cases were included. HNSpCC primarily affects adult males, with the larynx being the most common site, followed by the oral cavity and oropharynx, often presenting as polypoid/exophytic tumors. Diagnosis requires careful use of immunohistochemistry, especially vimentin and epithelial markers. Genetic alterations included <em>TP53, EGFR, ALK</em>, and <em>PIK3CA</em> mutations. Surgery was the main treatment; however, local recurrences, regional and distant metastases were frequent. Survival outcomes were influenced by tumor site, stage, and recurrence. Oral cavity tumors showed the worst prognosis, while laryngeal tumors had comparatively better survival.</div></div><div><h3>Conclusions</h3><div>HNSpCC is an aggressive malignancy with poor outcomes, especially in advanced-stage and oral cavity cases.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102695"},"PeriodicalIF":2.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.jormas.2025.102693
Benedikta Kamdem , Oumama El Ezzi , Sophie Fries , Laurent Medinger , Anthony S. de Buys Roessingh
Objective
To analyse the effect of maxillary advancement on speech in patients born with unilateral or bilateral cleft lip and palate (uCLP/bCLP).
Methods
Using the retrospective cohort study design, the investigators included children with uCLP or bCLP who underwent Le Fort I osteotomy for maxillary advancement between January 2013 and December 2023 at a Swiss university hospital. Predictor variables were cleft type (uCLP/bCLP) and amount of maxillary advancement measured on lateral cephalograms. The primary outcome was speech competency evaluated by two speech therapists using the Borel-Maisonny classification (A: velopharyngeal competence/excellent speech; B: borderline competence/good speech; C: incompetence/poor speech). Appropriate statistical analyses were performed, and P < 0.05 was considered statistically significant.
Results
Forty-three non-syndromic CLP patients (mean age 16.4 ± 1.5 years; 37 % female) were included. The mean maxillary advancement was 6.6 ± 2.3 mm. Of the 36 patients classified as A or B preoperatively, 34 showed no change, while two (5.6 %) deteriorated from A to B. All seven patients with preoperative category C remained unchanged. Neither cleft type nor the extent of maxillary advancement significantly influenced postoperative speech (p = 0.65 and p = 0.80, respectively).
Conclusion
Although limited by sample size, this study suggests that speech deterioration after maxillary advancement in CLP patients with preoperative category A or B is uncommon. Conversely, Le Fort I osteotomy does not appear to improve speech in patients with preoperative category C.
目的：分析先天性单侧或双侧唇腭裂（uCLP/bCLP）患者上颌前移对言语功能的影响。方法：采用回顾性队列研究设计，研究人员纳入2013年1月至2023年12月在瑞士大学医院接受Le Fort I截骨术进行上颌推进的uCLP或bCLP儿童。预测变量为裂唇类型（uCLP/bCLP）和侧位头颅x线片测量的上颌前移量。主要结果是由两名语言治疗师使用Borel-Maisonny分类（A：腭咽能力/出色的语言；B：边缘能力/良好的语言；C：无能/糟糕的语言）评估语言能力。进行相应的统计分析，P < 0.05为有统计学意义。结果：纳入43例非综合征性CLP患者（平均年龄16.4±1.5岁，女性占37%）。上颌平均前移6.6±2.3 mm。36例术前A、B级患者中，34例无变化，2例（5.6%）从A级恶化为B级。7例术前C级患者保持不变。腭裂类型和上颌前进程度对术后言语均无显著影响（p = 0.65,p = 0.80）。结论：尽管受样本量限制，本研究提示术前A或B级CLP患者上颌前移后言语功能恶化的情况并不常见。相反，Le Fort I型截骨术并不能改善术前C类患者的语言能力。
{"title":"Speech outcomes following Le Fort I maxillary advancement in cleft lip and palate patients: A retrospective evaluation using the Borel-Maisonny classification","authors":"Benedikta Kamdem , Oumama El Ezzi , Sophie Fries , Laurent Medinger , Anthony S. de Buys Roessingh","doi":"10.1016/j.jormas.2025.102693","DOIUrl":"10.1016/j.jormas.2025.102693","url":null,"abstract":"<div><h3>Objective</h3><div>To analyse the effect of maxillary advancement on speech in patients born with unilateral or bilateral cleft lip and palate (uCLP/bCLP).</div></div><div><h3>Methods</h3><div>Using the retrospective cohort study design, the investigators included children with uCLP or bCLP who underwent Le Fort I osteotomy for maxillary advancement between January 2013 and December 2023 at a Swiss university hospital. Predictor variables were cleft type (uCLP/bCLP) and amount of maxillary advancement measured on lateral cephalograms. The primary outcome was speech competency evaluated by two speech therapists using the Borel-Maisonny classification (A: velopharyngeal competence/excellent speech; B: borderline competence/good speech; C: incompetence/poor speech). Appropriate statistical analyses were performed, and <em>P</em> < 0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>Forty-three non-syndromic CLP patients (mean age 16.4 ± 1.5 years; 37 % female) were included. The mean maxillary advancement was 6.6 ± 2.3 mm. Of the 36 patients classified as A or B preoperatively, 34 showed no change, while two (5.6 %) deteriorated from A to B. All seven patients with preoperative category C remained unchanged. Neither cleft type nor the extent of maxillary advancement significantly influenced postoperative speech (<em>p</em> = 0.65 and <em>p</em> = 0.80, respectively).</div></div><div><h3>Conclusion</h3><div>Although limited by sample size, this study suggests that speech deterioration after maxillary advancement in CLP patients with preoperative category A or B is uncommon. Conversely, Le Fort I osteotomy does not appear to improve speech in patients with preoperative category C.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102693"},"PeriodicalIF":2.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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