Journal of Stomatology Oral and Maxillofacial Surgery最新文献

英文中文

The effect of probiotics on severe oral mucositis in cancer patients undergoing chemotherapy and/or radiotherapy: A meta-analysis 益生菌对接受化疗和/或放疗的癌症患者严重口腔黏膜炎的影响：一项元分析

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101983

ZhiYi Zhu , Wenting Pan , Xianqing Ming , Jiale Wu , Xinyue Zhang , Junfeng Miao , Wei Cui

Purpose

Oral mucositis is a frequent adverse reaction in cancer treatment. Probiotics exhibit anti-inflammatory and immunomodulatory properties that could prevent the occurrence of severe oral mucositis (SOM) induced by chemotherapy or radiation therapy in patients. This meta-analysis aimed to investigate the influence of probiotics on the incidence of SOM in cancer patients undergoing chemotherapy and/or radiotherapy.

Methods

We conducted a comprehensive search in PubMed, Embase, the Cochrane Library, and the China National Knowledge Infrastructure (CNKI) from their inception to September 2023. Dichotomous variables are analyzed with odds ratios (ORs) with 95% CIs, and statistical significance was set at a two-tailed P <0 .05. The primary outcome indicator was the effect of probiotics on SOM. Secondary outcome indicators included the effect of probiotics on oral mucositis and the ratio of diarrhoea. Statistical analysis was conducted using RevMan (5.4) and Stata 17.0 software.

Results

The study included a total of 12 articles and involved 1055 patients. All patients had undergone either radiotherapy or chemotherapy. Our findings revealed that the experimental group, which received probiotics for treatment, exhibited a lower ratio of SOM compared to the control group that received traditional placebo treatment (OR=0.37, 95%CI [0.28, 0.50], P<0.01). Subgroup analysis revealed variations in the ratio of SOM based on therapeutic regimen, tumor type, and region. The overall ratio of oral mucositis was significantly lower in the experimental group compared to the control group (OR=0.19, 95%CI [0.09-0.39], P<0.01). The ratio of diarrhea in the two patient groups showed no significant difference (OR=0.85, 95%CI [0.24, 3.01], P>0.05).

Conclusion

The results of this meta-analysis suggest that probiotics could decrease the occurrence of SOM.

目的：口腔黏膜炎是癌症治疗中经常出现的不良反应。益生菌具有抗炎和免疫调节特性，可预防化疗或放疗引起的严重口腔黏膜炎（SOM）。本荟萃分析旨在研究益生菌对接受化疗和/或放疗的癌症患者SOM发生率的影响：方法：我们在 PubMed、Embase、Cochrane 图书馆和中国国家知识基础设施（CNKI）中进行了全面检索，检索时间为 PubMed、Embase、Cochrane 图书馆和中国国家知识基础设施（CNKI）开始至 2023 年 9 月。二分变量的分析采用几率比（OR）和 95% CI，统计显著性采用双尾 P 结果：研究共包括 12 篇文章，涉及 1055 名患者。所有患者均接受过放疗或化疗。我们的研究结果显示，与接受传统安慰剂治疗的对照组相比，接受益生菌治疗的实验组的 SOM 比率较低（OR=0.37，95%CI [0.28，0.50]，P0.05）：这项荟萃分析的结果表明，益生菌可减少 SOM 的发生。

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引用次数: 0

A trans-eyebrow zig-zag approach for frontal bone fractures✰ 额骨骨折的 "之 "字形横眉法。

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101972

Daniel Dilworth, David Johnston, Donal McAuley, Peter Gordon

Frontal bone fractures are amongst the most common facial fractures and surgical management, which has traditionally involved access via a coronal flap, can result in unsightly scarring, alopecia, paraesthesia, facial nerve weakness and temporal hollowing. Alternative approaches include use of endoscopically-assisted surgery, often through the eyebrow, which minimises the risk of unsightly scarring but may also sacrifice access in the process. In this technical note, we discuss a surgical technique for open reduction and internal fixation of fractures of the bone overlying the frontal sinus and supra-orbital rim, which the authors have not found in the literature, which involves the making of a “zig-zag” incision through the eyebrow in a trichophytic manner which reduces the risk of unsightly scarring whilst simultaneously allowing for sufficient surgical access to the fracture site.

额骨骨折是最常见的面部骨折之一，传统的手术治疗方法是通过冠状皮瓣入路，这可能会导致难看的疤痕、脱发、麻痹、面神经无力和颞部凹陷。替代方法包括使用内窥镜辅助手术，通常是通过眉毛进行手术，这样可以将留下难看疤痕的风险降到最低，但也可能在手术过程中牺牲手术通道。在本技术说明中，我们将讨论作者在文献中未发现的额窦和眶上缘上覆骨骨折切开复位和内固定的手术技术，该技术包括以三叶形方式通过眉毛做一个 "之 "字形切口，这样既能降低留下难看疤痕的风险，又能使手术充分进入骨折部位。

引用次数: 0

Relationship of buccolingual inclination between the alveolar bone and first molar in different vertical facial types: A CBCT study 不同垂直脸型的牙槽骨与第一磨牙之间的颊舌向倾角关系：CBCT 研究。

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101974

Xingyu Cui , Huajing Tang , Yunlin Zhang , Yuanna Zheng , Xingnan Lin

Background

This study aimed to investigate the differences in the buccolingual inclination and transverse width of maxillary and mandibular first molars among different vertical facial types.

Methods

In all, 78 samples were divided into three groups based on the GoGn-SN angle: the low-angle group (n = 26, mean age=24.21±5.11), average-angle group (n = 26, mean age=22.66±3.72), and high-angle group (n = 26, mean age=22.23±2.43). Cone beam computed tomography (CBCT) measurements were used to assess the buccolingual inclination of the axis of the maxillary and mandibular first molars, as well as the buccolingual inclination of the alveolar bone, the dental arch width, and the basal bone width. One-way ANOVA, the LSD test, and Pearson correlation analysis were performed.

Results

The high-angle group showed significantly greater lingual inclination of the maxillary alveolar bone than the low-angle group and average-angle group (p < 0.001; p < 0.05). The difference in buccolingual inclination of the axis of the maxillary first molar and the alveolar bone was significantly greater in the high-angle group than in the low-angle group (p < 0.05). Both the maxillary and mandibular dental arch were significantly narrower in the high-angle group than in the other two groups. The mandibular basal bone was also significantly narrower in the high-angle group than in the low-angle group and average-angle group (p < 0.001; p < 0.01).

Conclusions

The alveolar bone of maxillary first molar in the high-angle group was more palatal inclined than that the low-angle group and the average-angle group, which suggests that orthodontists should pay more attention to the root-bone relationship in the high-angle group during expansion treatment to prevent bone fenestration and dehiscense.

背景：本研究旨在探讨不同垂直脸型的上颌和下颌第一磨牙的颊舌倾斜和横向宽度的差异：本研究旨在探讨不同垂直脸型的上下颌第一磨牙颊舌倾斜度和横向宽度的差异：根据 GoGn-SN 角度将 78 例样本分为三组：低角度组（26 例，平均年龄（24.21±5.11）岁）、平均角度组（26 例，平均年龄（22.66±3.72）岁）和高角度组（26 例，平均年龄（22.23±2.43）岁）。锥形束计算机断层扫描（CBCT）测量用于评估上颌和下颌第一磨牙轴的颊舌向倾斜度，以及牙槽骨的颊舌向倾斜度、牙弓宽度和基底骨宽度。研究人员进行了单因素方差分析、LSD 检验和皮尔逊相关分析：结果：高角度组的上颌骨牙槽骨舌侧倾角明显大于低角度组和平均角度组（p结论：高角度组的上颌骨牙槽骨舌侧倾角明显大于低角度组和平均角度组：高角度组上颌第一磨牙的牙槽骨比低角度组和平均角度组的牙槽骨更偏向腭侧，这表明正畸医生在扩弓治疗时应更加关注高角度组的牙根-牙槽骨关系，以防止牙槽骨瘘裂和开裂。

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引用次数: 0

Is panoramic radiography adequate for diagnosing coronoid process hyperplasia? A case series 全景放射照相术是否足以诊断冠状突增生？一个案例系列。

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2023.101487

Introduction

The objective of this study was to compare the length ratios obtained on panoramic radiography and computed tomography (CT) to verify whether the former is adequate for diagnosing coronoid process hyperplasia.

Methods

A case series of patients with coronoid process hyperplasia was investigated. Length ratios between the coronoid process and condyle were measured on panoramic radiographs by using the Levandoski method and on CT scans by using the methods described by Tavassol et al. and Stopa et al. The mean length ratios obtained using the three measurement methods were compared.

Results

The mean length ratio measured with the Levandoski method was significantly lower than that measured with the method described by Stopa et al. (1.09 [0.09] vs. 1.21 [0.09]; P = 0.0001) and lower than that measured with the method described by Tavassol et al. (1.09 [0.09] vs. 1.34 [0.44]; P = 0.013).

Conclusion

Panoramic measurement of the coronoid process by using the Levandoski method tended to underestimate the length ratio, emphasizing the importance of using a scanographic measurement method at the slightest doubt to confirm the diagnosis of coronoid process hyperplasia.

引言：本研究的目的是比较全景摄影和计算机断层扫描（CT）获得的长度比，以验证前者是否足以诊断冠状突增生。方法：对一系列冠状突增生患者进行调查。冠状突和髁突之间的长度比在全景射线照片上使用Levandoski方法测量，在CT扫描上使用Tavasol等人和Stopa等人描述的方法测量。比较使用三种测量方法获得的平均长度比。结果：用Levandoski方法测量的平均长度比显著低于Stopa等人描述的方法测量的长度比（1.09[0.09]vs.1.21[0.09]；P=0.0001），也低于Tavasol等人描述的测量方法测量的长径比（1.09%0.09]vs.1.34[0.44]；P=0.013）方法倾向于低估长度比，强调在最有疑问的情况下使用扫描测量方法来确认冠状突增生诊断的重要性。

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引用次数: 0

Revolutionizing oral and maxillofacial surgery: The role of DALL-E's AI-generated realistic images in enhancing surgical precision 革新口腔颌面外科手术：DALL-E 人工智能生成的逼真图像在提高手术精确度方面的作用。

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101874

引用次数: 0

Novel role of CD34+ stromal cells/telocytes in oral submucous fibrosis development and its malignant transformation CD34+ 基质细胞/髓鞘细胞在口腔黏膜下纤维化发展及其恶性转化中的新作用

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101990

Poonguzhalnalli Kumar , Dineshkumar Thayalan , Divya Bose , Rajkumar Krishnan , Rameshkumar Annasamy , Indumathi N

Background

Telocytes are interstitial cells widely distributed in the extracellular matrix of numerous tissues distinguished by their long, thin, and moniliform projections. Telocytes have a role in the stimulation of angiogenesis and contribute to the development and progression of fibrosis.

Aim

The current study aimed to assess and compare the telocyte distribution in normal mucosa, oral submucous fibrosis (OSF), and OSCC associated with OSF (OSCCOSF).

Materials and Methods

Formalin-fixed and paraffin-embedded tissue blocks of 30 OSF cases, 15 OSCCOSF cases, and 15 normal oral mucosae were obtained. Immunohistochemical staining was done with antibodies to CD34 to assess the vasculature and telocytes. The mean vascular density (MVD) and mean telocyte density were compared between the groups using the Kruskal-Walli test.

Results

A statistically significant high MVD (3.4 ± 1.22) and mean telocyte density (3.8 ± 1.35) was observed in OSCCOSF cases while it was lowest in advanced OSF cases. MVD was higher in early OSF cases than in normal mucosa.

Conclusion

This study showed a decrease in CD34-positive telocytes in OSF, indicating that telocyte loss promotes the development of fibrosis.Increased angiogenesis coexisted with an increase in telocytes in OSCCOSF.

背景：端粒细胞是广泛分布于许多组织细胞外基质中的间质细胞，其特征是具有细长的单形突起。目的：本研究旨在评估和比较正常黏膜、口腔黏膜下纤维化（OSF）和伴有OSF的OSCC（OSCC-OSF）中端细胞的分布情况：获取 30 例 OSF、15 例 OSCC-OSF 和 15 例正常口腔黏膜的福尔马林固定和石蜡包埋组织块。用 CD34 抗体进行免疫组化染色，以评估血管和端粒细胞。采用 Kruskal-Walli 检验比较了组间的平均血管密度（MVD）和平均端粒细胞密度：结果：OSCC-OSF病例的平均血管密度（3.4 ± 1.22）和平均端粒细胞密度（3.8 ± 1.35）明显高于晚期OSF病例，差异具有统计学意义。早期OSF病例的MVD高于正常粘膜：本研究显示，OSF中CD34阳性端粒细胞减少，表明端粒细胞的丢失促进了纤维化的发展。

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引用次数: 0

Biomechanical and biological advantages of retaining the silicone-induced capsule for cartilage graft survival in revision rhinoplasty 在翻修鼻整形术中保留硅胶诱导囊对软骨移植物存活的生物力学和生物学优势。

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101935

To answer the increased demand for augmentation rhinoplasty, particularly in Asian demographics, a shift from autogenous materials to synthetic implants like silicone and expanded polytetrafluoroethylene has been witnessed. These materials present an increased risk of complications like infection, extrusion, capsular contracture, and dissatisfaction. This study focuses on a case of revision rhinoplasty in a 48-year-old patient with a previous silicone implant and propose an innovative approach in managing the implant capsule. The use of the existing capsule as a mechanical and biological support structure for the diced cartilage graft in dorsal reconstruction showcases a promising method to mitigate risks and improve outcomes in revision surgeries. The capsule around the silicone is biologically active and provides a good environment for the cartilage graft to survive and improve the healing process. This approach tends to minimize the dissection to avoid potential revision complications like skin necrosis, fibrotic tissue, and infections.

为了满足日益增长的隆鼻需求，尤其是亚洲人的需求，自体材料已开始向硅胶和膨体聚四氟乙烯等合成植入物转变。这些材料会增加感染、挤出、囊挛和不满意等并发症的风险。本研究的重点是一例曾使用硅胶假体的 48 岁患者的翻修鼻整形手术，并提出了一种管理假体囊的创新方法。在鼻背重建手术中，将现有的囊作为丁状软骨移植的机械和生物支持结构，展示了一种在翻修手术中降低风险和改善效果的可行方法。硅胶周围的囊具有生物活性，可为软骨移植物提供良好的生存环境，改善愈合过程。这种方法倾向于尽量减少剥离，以避免潜在的翻修并发症，如皮肤坏死、纤维组织和感染。

引用次数: 0

Letter to the editor: “Can natural language processing serve as a consultant in oral surgery?” 致编辑的信："自然语言处理能否成为口腔外科的顾问？

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101963

引用次数: 0

Cytotoxicity evaluation of Chlorhexidine and Blue®M applied to a human gingival fibroblast (HGF-1) and keratinocytes (NOK-SI): In vitro study 应用于人牙龈成纤维细胞（HGF-1）和角质形成细胞（NOK-SI）的洗必泰和蓝®M 的细胞毒性评估：体外研究。

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101923

Chlorhexidine (CHX) is a prime choice to control the oral microbiota. However, it's a chemical agent leading to side effects such as teeth strains, taste disturbance, and desquamation of oral mucosa. Alternatively, the lactoferrin and oxygen-based Blue®M has been introduced as an alternative to the CHX, not disturbing tissue repair. Therefore, the study aimed to evaluate the effects of Blue®M and CHX on oral human fibroblasts (HGF-1) and keratinocytes (NOK-SI). Cell cultures using HGF-1 and NOK-SI evaluated cell proliferation, cell cycle, apoptosis and necrosis, and migration. In the dose-effect test, Blue®M reduced the HGF-1 sample in a 4-fold concentration than CHX (CHX: 173.07 ±10.27; Blue®M: 43.86 ±3.04). The proliferation test revealed an eightfold reduction of the sample for CHX, while for Blue®M, the proliferation rate was eighteen times lower. The apoptosis and necrosis rates increased by 25% (p<0.0001) for HGF-1 for both substances. In NOK-SI, the apoptosis rates increased by 10% (p=0.02) and 15% (p=0.001) for CHX and Blue®M, respectively. Furthermore, the fibroblast had a lower capacity for wound closure in the Scratch Assay (monolayer cell migration) for Blue®M. Despite the limitations of this in vitro study, the results of the lactoferrin and oxygen-based Blue®M demonstrated cytotoxicity in doses over the Minimum inhibitory concentration and Minimum bactericidal concentration for Oral fibroblasts (HGF- 1) and Keratinocytes (NOK-SI).

洗必泰（CHX）是控制口腔微生物群的首选。然而，它是一种化学制剂，会导致牙齿拉伤、味觉障碍和口腔粘膜脱屑等副作用。作为 CHX 的替代品，乳铁蛋白和氧基 Blue®M 的出现不会影响组织修复。因此，本研究旨在评估 Blue®M 和 CHX 对口腔人类成纤维细胞（HGF-1）和角质细胞（NOK-SI）的影响。使用 HGF-1 和 NOK-SI 进行的细胞培养评估了细胞增殖、细胞周期凋亡和坏死以及迁移。在剂量效应测试中，Blue®M 减少 HGF-1 样品的浓度是 CHX 的 4 倍（CHX：173.07 ±10.27；Blue®M：43.86 ±3.04）。增殖测试显示，CHX 可使样品的增殖率降低 8 倍，而 Blue®M 则降低了 18 倍。凋亡率和坏死率增加了 25%（p

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引用次数: 0

Automatic detection of midfacial fractures in facial bone CT images using deep learning-based object detection models 使用基于深度学习的物体检测模型自动检测面部骨骼 CT 图像中的面部中间骨折。

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jormas.2024.101914

Background

Midfacial fractures are among the most frequent facial fractures. Surgery is recommended within 2 weeks of injury, but this time frame is often extended because the fracture is missed on diagnostic imaging in the busy emergency medicine setting. Using deep learning technology, which has progressed markedly in various fields, we attempted to develop a system for the automatic detection of midfacial fractures. The purpose of this study was to use this system to diagnose fractures accurately and rapidly, with the intention of benefiting both patients and emergency room physicians.

Methods

One hundred computed tomography images that included midfacial fractures (e.g., maxillary, zygomatic, nasal, and orbital fractures) were prepared. In each axial image, the fracture area was surrounded by a rectangular region to create the annotation data. Eighty images were randomly classified as the training dataset (3736 slices) and 20 as the validation dataset (883 slices). Training and validation were performed using Single Shot MultiBox Detector (SSD) and version 8 of You Only Look Once (YOLOv8), which are object detection algorithms.

Results

The performance indicators for SSD and YOLOv8 were respectively: precision, 0.872 and 0.871; recall, 0.823 and 0.775; F1 score, 0.846 and 0.82; average precision, 0.899 and 0.769.

Conclusions

The use of deep learning techniques allowed the automatic detection of midfacial fractures with good accuracy and high speed. The system developed in this study is promising for automated detection of midfacial fractures and may provide a quick and accurate solution for emergency medical care and other settings.

背景：面中部骨折是最常见的面部骨折之一。建议在受伤后 2 周内进行手术，但由于在繁忙的急诊医学环境中诊断成像漏掉了骨折，手术时间往往被延长。深度学习技术在各个领域都取得了显著进展，我们试图利用该技术开发一套自动检测面部正中骨折的系统。本研究的目的是利用该系统准确、快速地诊断骨折，以期使患者和急诊室医生都能从中受益：方法：准备了 100 张包括面部中部骨折（如上颌骨、颧骨、鼻骨和眼眶骨折）的计算机断层扫描图像。在每张轴向图像中，骨折区域被一个矩形区域包围，以创建标注数据。80 张图像被随机归类为训练数据集（3736 片），20 张图像被随机归类为验证数据集（883 片）。训练和验证均使用物体检测算法 Single Shot MultiBox Detector（SSD）和 You Only Look Once（YOLOv8）第 8 版进行：SSD和YOLOv8的性能指标分别为：精确度0.872和0.871；召回率0.823和0.775；F1得分0.846和0.82；平均精确度0.899和0.769：深度学习技术的使用使得面中部骨折的自动检测具有良好的准确性和较高的速度。本研究开发的系统有望用于面中部骨折的自动检测，并可为紧急医疗护理和其他场合提供快速、准确的解决方案。

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