Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"An oral microbiome from 1929: Paleoproteomic study of a toothbrush belonging to Georges Clemenceau (1841–1929).","authors":"P Charlier , L Lentignac , J Armengaud","doi":"10.1016/j.jormas.2025.102691","DOIUrl":"10.1016/j.jormas.2025.102691","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102691"},"PeriodicalIF":2.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthognathic surgery in instability of the TMJ using surgical guides and customized plates: 3 case reports","authors":"Kiatanant Boonsiriseth ,&nbsp;Nutnicha Naknual ,&nbsp;Chedtha Puncreobutr ,&nbsp;Sukkarn Themkumkwun","doi":"10.1016/j.jormas.2025.102689","DOIUrl":"10.1016/j.jormas.2025.102689","url":null,"abstract":"<div><h3>Purpose</h3><div>Patients with facial deformities and temporomandibular joint (TMJ) instability present unique challenges in orthognathic surgery (OGS). This report presents three complex cases of syndromic or post-traumatic deformities treated with virtual surgical planning (VSP), surgical guides, and customized fixation plates.</div></div><div><h3>Methods</h3><div>Three patients with syndromic or post-traumatic deformities and TMJ instability underwent OGS. Planning was performed using Dolphin Imaging software. Surgical guides and patient-specific plates were designed with CAD software and fabricated via selective laser melting. Surgical workflows incorporated bone- and tooth-borne guides, with fixation achieved using customized titanium plates. Postoperative accuracy was evaluated by superimposing pre- and postoperative computed tomography (CT) scans.</div></div><div><h3>Results</h3><div>Superimposition analysis revealed maximum surface deviations of less than 2 mm in all patients, with the maxilla demonstrating superior accuracy (&lt;1 mm). Clinically, all patients showed improved facial symmetry, occlusion, and profile. The use of surgical guides and customized plates enhanced intraoperative precision and reduced the risk of root and nerve injury.</div></div><div><h3>Conclusion</h3><div>Guided surgery with customized fixation improve surgical accuracy and outcomes in patients with complex deformities and TMJ instability. These results support the application of surgical guides and customized plates in challenging orthognathic cases.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102689"},"PeriodicalIF":2.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameloblastoma in Chongqing children and adolescents: a review of 16 cases","authors":"Ying Xu,&nbsp;Xiao-Juan Fu,&nbsp;Li Xiang,&nbsp;Wan-Shan Li","doi":"10.1016/j.jormas.2025.102687","DOIUrl":"10.1016/j.jormas.2025.102687","url":null,"abstract":"<div><h3>Background</h3><div>Ameloblastoma is a benign tumor of odontogenic epithelial origin, characterized by local aggression and a high recurrence rate in adults. Although rare in children, it accounts for 10 to 15 % of all ameloblastoma cases. However, a consensus on the clinicopathological features and treatment protocols for this condition remains lacking.</div></div><div><h3>Purpose</h3><div>This study aims to summarize the clinicopathological characteristics of ameloblastoma in pediatric patients within the oral and maxillofacial regions.</div></div><div><h3>Methods</h3><div>Clinical, radiological, and histological data from sixteen pediatric patients who underwent surgical curettage followed by pathological diagnosis of ameloblastoma were retrospectively analyzed.</div></div><div><h3>Results</h3><div>The cohort comprised 11 males and 5 females, yielding a male-to-female ratio of 2.1:1. Patient age at diagnosis ranged from 2 to 13 years (mean age: 7.6 years). Lesions were located in the maxilla in two cases and the mandible in fourteen. Within the mandible, lesions were predominantly found in the posterior teeth region (7 cases, 50.0 %), followed by the mandibular angle (3 cases, 21.43 %), the angle and ramus (1 case, 7.14 %), the ramus (1 case, 7.14 %), the midline of the mandible (1 case, 7.14 %), and the anterior mandible (1 case, 7.14 %). Painless swelling was the most common symptom, observed in 9 of 16 patients (56.25 %). All patients were treated surgically. Radiological findings revealed unilocular lesions in 14 cases, while 2 cases exhibited multilocular lesions. Histologically, 14 cases presented with the solid type, and 2 cases with the unicystic type. Postoperative follow-up ranged from 1 to 81 months, with one recurrence.</div></div><div><h3>Conclusions</h3><div>The recurrence rate of ameloblastoma in children is relatively low. Unicystic ameloblastoma is more prevalent in this population. Simple surgical curettage typically results in a favorable prognosis with minimal recurrence. Early and accurate recognition of the disease’s clinical, radiological, and histological features is critical in reducing misdiagnosis.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102687"},"PeriodicalIF":2.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of fracture fragment displacement on sensory function recovery of the inferior alveolar nerve in mandibular angle fractures","authors":"Zhihui Huang","doi":"10.1016/j.jormas.2025.102684","DOIUrl":"10.1016/j.jormas.2025.102684","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the correlation between the initial, three-dimensionally quantified displacement of mandibular angle fractures and the prognosis of inferior alveolar nerve (IAN) sensory function recovery following open reduction and internal fixation (ORIF).</div></div><div><h3>Methods</h3><div>This retrospective cohort study included patients with unilateral mandibular angle fractures treated with ORIF between March 2022 and August 2025. Preoperative cone-beam computed tomography (CBCT) was used to measure the maximum 3-dimensional (3D) displacement of the fracture fragments. Patients were stratified into three groups based on displacement: mild (&lt;2 mm), moderate (2–5 mm), and severe (&gt;5 mm). IAN sensory function was systematically evaluated through objective tests (light touch, two-point discrimination, and pinprick) and subjective tests (Visual Analog Scale) at preoperative, 1 week, 1 month, 3 months, 6 months, and 12 months follow-ups. Multivariate logistic regression was used to identify independent predictors for complete sensory recovery.</div></div><div><h3>Results</h3><div>A total of 128 patients were included: 45 in the mild, 52 in the moderate, and 31 in the severe displacement groups. The incidence of preoperative IAN sensory deficit was significantly higher in the severe group (67.7%) compared to the moderate (34.6%) and mild (11.1%) groups (<em>p</em> &lt; 0.001). At the 12-month follow-up, the complete recovery rates were 91.1%, 63.5%, and 22.6% for the mild, moderate, and severe groups, respectively (<em>P</em> &lt; 0.001). Multivariable logistic regression identified severe displacement (OR = 0.09, 95% CI: 0.03–0.29), moderate displacement (OR = 0.28, 95% CI: 0.11–0.71), and age&gt;40 years (OR = 0.41, 95% CI: 0.18–0.93) as independent negative predictors for complete sensory recovery.</div></div><div><h3>Conclusion</h3><div>The initial 3D displacement of mandibular angle fractures is a significant predictor of IAN injury severity and postoperative sensory recovery. Preoperative quantitative assessment using CBCT may aid in personalized prognosis, patient counseling, and surgical planning.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102684"},"PeriodicalIF":2.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Success rate of dental implants in HIV patients: an overview of systematic reviews","authors":"Ana Waleska Pessôa Barros de AGUIAR ,&nbsp;Pedro Henrique da Hora SALES ,&nbsp;Marco MELETI ,&nbsp;Alessandra Albuquerque Tavares CARVALHO ,&nbsp;Paolo VESCOV ,&nbsp;Jair Carneiro LEÃO","doi":"10.1016/j.jormas.2025.102685","DOIUrl":"10.1016/j.jormas.2025.102685","url":null,"abstract":"<div><div>Aims: To identify whether individuals with positive serology for HIV have a higher risk of losing the dental implant for this treatment. Methods and results: This study was conducted according to PRISMA guidelines and registered in the international prospective registry of systematic reviews, PROSPERO. The databases consulted were MEDLINE via PubMed, Scopus, DARE Cochrane, LILACS, Base, and Google Scholar. The search descriptors: “HIV,” “dental implants” and “AIDS” were used. To assess methodological quality, the AMSTAR 2 tool was used, and the entire process was reviewed in pairs, in addition, a third evaluator was consulted in case of disagreement. Four systematic reviews were included, encompassing 1239 implants in 450 patients with positive serology for HIV. Success rate of the dental implants was 94.72%, with a standard deviation of 0.455%. Three were classified as critically low-quality and one as moderate-quality. Conclusion: Similar implant survival rates were observed in HIV-negative patients. Therefore, the disease itself does not appear to have a significant influence on osseointegration. New controlled studies with low bias and high methodological quality are needed to ensure rehabilitation with dental implants with greater predictability and safety for HIV individuals.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102685"},"PeriodicalIF":2.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and application of Tai Chi modification of the contralateral submental flap","authors":"Lin Wang ,&nbsp;Dongpo Li ,&nbsp;Fengzhi Liu ,&nbsp;Haijun Zhao ,&nbsp;Xiurong Chen ,&nbsp;Shuangyi Wang","doi":"10.1016/j.jormas.2025.102690","DOIUrl":"10.1016/j.jormas.2025.102690","url":null,"abstract":"<div><h3>Background</h3><div>Tai Chi flap began as a novel design for a radial forearm flap. There have been no reports of submental island Tai Chi flap. This study aims to investigate the feasibility of the Tai Chi modification of the submental flap in the repair of tongue cancer-related defects.</div></div><div><h3>Methods</h3><div>This project was designed as a retrospective cohort study. Clinical data of patients who underwent contralateral Tai Chi modification of the submental flap repair after tongue cancer resection at our institution from April 2024 to April 2025 were retrospectively analyzed.</div></div><div><h3>Results</h3><div>The cohort consisted of 4 patients (3 males and 1 female). No significant postoperative flap necrosis was seen, with only 1 case of tip bruising. In terms of tension in the donor area, the patients self-reported no significant tension in the neck, and no incision cracking was seen after suture removal on the 7th postoperative day. The patient's tongue function recovered well after surgery.</div></div><div><h3>Conclusions</h3><div>The submental island Tai Chi modification of the submental flap reconstructs tongue cancer defects with good postoperative functional recovery. And with low neck tension, the neck suture can be removed earlier.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102690"},"PeriodicalIF":2.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing AI-driven clinical anamnesis: Insights from a comparative evaluation of large language models in oral and maxillofacial diagnosis","authors":"Weihao Cheng","doi":"10.1016/j.jormas.2025.102682","DOIUrl":"10.1016/j.jormas.2025.102682","url":null,"abstract":"","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102682"},"PeriodicalIF":2.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Impact of the need for dental extractions on oral health-related quality of life in patients with cirrhosis: A cross-sectional study”","authors":"Janaina B. Medina ,&nbsp;Wallena Albuquerque-da-Cunha ,&nbsp;Andrés Blanco-Carrión ,&nbsp;Maria Paula Siqueira de Melo Peres ,&nbsp;Karem L. Ortega ,&nbsp;Juliana Bertoldi Franco","doi":"10.1016/j.jormas.2025.102681","DOIUrl":"10.1016/j.jormas.2025.102681","url":null,"abstract":"<div><h3>Introduction</h3><div>Liver cirrhosis significantly compromises patients’ physical and psychological health, leading to a marked reduction in quality of life (QoL). In addition to systemic complications oral health problems are prevalent and may exacerbate malnutrition, risk of infection, and overall clinical deterioration<strong>.</strong> Oral health–related quality of life (OHRQoL) is increasingly recognized as a relevant outcome in cirrhosis, yet it remains unclear whether acute dental needs, such as tooth extractions, further deteriorate patients’ perceived burden. Poor oral health can be particularly critical in patients awaiting liver transplantation, who often require urgent dental interventions due to infection foci, frequently resulting in multiple tooth extractions. Assessing the impact of oral health on quality of life in this population is essential to support comprehensive pre-transplant care.</div></div><div><h3>Material &amp; Methods</h3><div>A cross-sectional study was conducted with 267 participants, divided into three groups: SG1 (cirrhosis with need for tooth extractions), SG2 (cirrhosis without need for tooth extractions), and CG (controls without cirrhosis). OHRQoL was assessed using the Oral Health Impact Profile (OHIP-14) questionnaire. The 14 items were analyzed according to seven predefined dimensions and a three-factor model. Exploratory factor analysis was performed, and the internal consistency of each factor was assessed using Cronbach’s alpha. Group comparisons were conducted using the Kruskal-Wallis test, followed by Mann-Whitney and Dwass-Steel-Critchlow-Fligner post hoc tests.</div></div><div><h3>Results</h3><div>Factor analysis confirmed the theoretical three-factor model (KMO = 0.888), with satisfactory internal consistency (Cronbach’s α &gt; 0.70 for all factors). Cirrhotic patients showed significantly worse OHRQoL than controls across all OHIP-14 factors (<em>p</em> &lt; 0.001), particularly in the psychological and physical dimensions. No significant differences were found between SG1 and SG2 in overall OHIP-14 scores, although SG1 presented worse scores in specific dimensions such as physical pain and social disability. The need for tooth extractions did not significantly affect overall OHRQoL, which remained moderate in both cirrhotic groups.</div></div><div><h3>Discussion</h3><div>Patients with liver cirrhosis awaiting liver transplantation experience a moderate negative impact of oral health on quality of life, predominantly in psychological and physical dimensions. Although the need for tooth extractions was associated with specific dimension scores, it did not significantly influence overall OHRQoL, suggesting that systemic disease burden plays a major role in patient perception.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102681"},"PeriodicalIF":2.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145751971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chatbot content analysis of patient information on orthodontic tooth extractions","authors":"Şule Gökmen ,&nbsp;Ebru Yurdakurban ,&nbsp;Kübra Gülnur Topsakal ,&nbsp;Gökhan Serhat Duran","doi":"10.1016/j.jormas.2025.102675","DOIUrl":"10.1016/j.jormas.2025.102675","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aims to evaluate the quality, accuracy, readability, and understandability of patient information provided by various Artificial intelligence (AI)-based chatbots regarding orthodontic tooth extractions</div></div><div><h3>Materials and methods</h3><div>Two researchers created a list of questions for patients to ask the chatbots. The questions were categorized into ‘Pre-extraction’ and ‘Post-extraction’, with 20 questions in each category. Four different criteria were used to evaluate the chatbot responses to 40 questions: the Global Quality Scale (GQS), the Simple Measure of Gobbledygook (SMOG), and the Understandability and Accuracy Index. Jamovi (The Jamovi Project, 2022, version 2.3; Sydney, Australia) software was used for all statistical analyses.</div></div><div><h3>Results</h3><div>The highest mean values were observed in Claude 3.5 sonnet for GQS, Readability, and Accuracy Index. In terms of readability, as measured by the SMOG index, all three AI-based chatbots required a college-level education for comprehension. In the 'Pre-extraction' and 'Post-extraction' sections, Claude 3.5 Sonnet demonstrated the highest mean values for the GQS, readability, and accuracy indices. In terms of Understandability subcriteria 1 and 2, statistically significant differences were observed among the three chatbots, primarily due to the variation between Gemini and Claude 3.5 Sonnet.</div></div><div><h3>Conclusion</h3><div>AI-based chatbots with a variety of features have generally provided answers of high quality, reliability, and difficult readability to questions. Although the medical information related to orthodontic tooth extraction supplied by chatbots is of higher quality, it is recommended that individuals consult their healthcare professionals on this issue.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102675"},"PeriodicalIF":2.0,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of heterodimeric G protein G12 family on proliferation, migration, and invasion in human oral squamous cell carcinoma cells","authors":"Tao-li Fang,&nbsp;Xiao-xia Ma,&nbsp;Sen Yang,&nbsp;Xue-hua Ma,&nbsp;Jiang Xu","doi":"10.1016/j.jormas.2025.102679","DOIUrl":"10.1016/j.jormas.2025.102679","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize the expression of G12 subfamily members (GNA13 and GNA12) in oral squamous cell carcinoma (OSCC) and to evaluate their functional roles in regulating OSCC cell proliferation, migration and invasion.</div></div><div><h3>Methods</h3><div>Public bioinformatic resources were interrogated to profile GNA12 and GNA13 expression and associated functional pathways. Immunohistochemistry was performed on 102 OSCC and 48 adjacent non‑neoplastic tissue specimens, with correlation analyses against clinicopathological parameters and patient survival. Protein and transcript levels were validated in OSCC cell lines by Western blotting and RT‑qPCR. Loss‑of‑function studies using siRNA were followed by CCK‑8, colony formation, Transwell migration/invasion and wound‑healing assays to assess cellular phenotypes.</div></div><div><h3>Results</h3><div>Bioinformatic analyses showed significant upregulation of GNA13 and GNA12 in OSCC (<em>P</em> &lt; 0.001) and enrichment of Rho-mediated signalling pathways. Immunohistochemistry confirmed increased GNA13 and GNA12 expression in tumour tissues compared with adjacent mucosa (<em>P</em> &lt; 0.05). GNA13 expression correlated with tumour differentiation (<em>P</em> = 0.013) and nodal metastasis (<em>P</em> = 0.033), whereas GNA12 expression correlated with tumour differentiation (<em>P</em> = 0.010) and clinical stage (<em>P</em> = 0.027). Overexpression of both genes was associated with poorer overall survival (<em>P</em> &lt; 0.001). Elevated expression in OSCC cell lines was validated by Western blot and RT-qPCR. Functional assays demonstrated that siRNA-mediated knockdown of GNA13 or GNA12 significantly reduced cell viability, colony formation, migration and invasion compared with controls (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Elevated expressions of GNA13 and GNA12 in OSCC tumor tissues and cells are associated with poor patient prognosis. Targeted knockout of GNA13 and GNA12 effectively suppresses malignant behaviors of OSCC, including cell proliferation, migration abilities, and invasive potential. The G12 subfamily may represent a novel therapeutic target for OSCC treatment.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"127 3","pages":"Article 102679"},"PeriodicalIF":2.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}