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Changes in opioid prescribing during the COVID-19 pandemic in England: an interrupted time-series analysis in the OpenSAFELY-TTP cohort. 英格兰 COVID-19 大流行期间阿片类药物处方的变化:OpenSAFELY-TTP 队列的间断时间序列分析。
IF 25.4 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-07-01 DOI: 10.1016/S2468-2667(24)00100-2
Andrea L Schaffer, Colm D Andrews, Andrew D Brown, Richard Croker, William J Hulme, Linda Nab, Jane Quinlan, Victoria Speed, Christopher Wood, Milan Wiedemann, Jon Massey, Peter Inglesby, Seb C J Bacon, Amir Mehrkar, Chris Bates, Ben Goldacre, Alex J Walker, Brian MacKenna

Background: The COVID-19 pandemic disrupted health-care delivery, including difficulty accessing in-person care, which could have increased the need for strong pharmacological pain relief. Due to the risks associated with overprescribing of opioids, especially to vulnerable populations, we aimed to quantify changes to measures during the COVID-19 pandemic, overall, and by key subgroups.

Methods: For this interrupted time-series analysis study conducted in England, with National Health Service England approval, we used routine clinical data from more than 20 million general practice adult patients in OpenSAFELY-TPP, which is a a secure software platform for analysis of electronic health records. We included all adults registered with a primary care practice using TPP-SystmOne software. Using interrupted time-series analysis, we quantified prevalent and new opioid prescribing before the COVID-19 pandemic (January, 2018-February, 2020), during the lockdown (March, 2020-March, 2021), and recovery periods (April, 2021-June, 2022), overall and stratified by demographics (age, sex, deprivation, ethnicity, and geographical region) and in people in care homes identified via an address-matching algorithm.

Findings: There was little change in prevalent prescribing during the pandemic, except for a temporary increase in March, 2020. We observed a 9·8% (95% CI -14·5 to -6·5) reduction in new opioid prescribing from March, 2020, with a levelling of the downward trend, and rebounding slightly after April, 2021 (4·1%, 95% CI -0·9 to 9·4). Opioid prescribing rates varied by demographics, but we found a reduction in new prescribing for all subgroups except people aged 80 years or older. Among care home residents, in April, 2020, parenteral opioid prescribing increased by 186·3% (153·1 to 223·9).

Interpretation: Opioid prescribing increased temporarily among older people and care home residents, likely reflecting use to treat end-of-life COVID-19 symptoms. Despite vulnerable populations being more affected by health-care disruptions, disparities in opioid prescribing by most demographic subgroups did not widen during the pandemic. Further research is needed to understand what is driving the changes in new opioid prescribing and its relation to changes to health-care provision during the pandemic.

Funding: The Wellcome Trust, Medical Research Council, The National Institute for Health and Care Research, UK Research and Innovation, and Health Data Research UK.

背景:COVID-19 大流行扰乱了医疗保健服务的提供,包括难以获得亲自护理,这可能会增加对强效药物止痛的需求。由于阿片类药物处方过量存在风险,尤其是对弱势群体而言,因此我们旨在量化 COVID-19 大流行期间总体和主要亚群体的措施变化:在这项在英格兰进行的间断时间序列分析研究中,我们使用了 OpenSAFELY-TPP 中 2000 多万名全科成年患者的常规临床数据,OpenSAFELY-TPP 是一个用于分析电子健康记录的安全软件平台。我们将使用 TPP-SystmOne 软件在全科诊所登记的所有成人纳入其中。利用间断时间序列分析法,我们对 COVID-19 大流行之前(2018 年 1 月至 2020 年 2 月)、封锁期间(2020 年 3 月至 2021 年 3 月)和恢复期(2021 年 4 月至 2022 年 6 月)的阿片类药物处方的普遍性和新增处方进行了量化,并按人口统计学(年龄、性别、贫困程度、种族和地理区域)和通过地址匹配算法确定的护理院患者进行了分层:大流行期间,除了 2020 年 3 月出现暂时性增长外,处方的普遍性变化不大。我们观察到,自 2020 年 3 月起,阿片类药物的新处方量减少了 9-8%(95% CI -14-5~-6-5),下降趋势趋于平缓,2021 年 4 月后略有反弹(4-1%,95% CI -0-9~9-4)。阿片类药物的处方率因人口统计学特征而异,但我们发现,除 80 岁或以上的老年人外,所有亚群体的新处方量都有所减少。在 2020 年 4 月的护理院居民中,肠外阿片类药物处方增加了 186-3%(153-1 至 223-9):在老年人和护理院住户中,阿片类药物处方量暂时有所增加,这可能反映了用于治疗临终COVID-19症状的情况。尽管弱势群体受到医疗服务中断的影响更大,但在大流行期间,大多数人口亚群在阿片类药物处方方面的差异并未扩大。需要进一步开展研究,以了解是什么因素导致了阿片类药物新处方的变化,以及这种变化与大流行期间医疗保健服务的变化之间的关系:资助机构:惠康信托基金会、医学研究委员会、英国国家健康与护理研究所、英国研究与创新组织以及英国健康数据研究组织。
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引用次数: 0
Increasing risks of dementia and brain health concerns. 增加患痴呆症和脑健康问题的风险。
IF 25.4 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-07-01 DOI: 10.1016/S2468-2667(24)00123-3
Abolfazl Avan, Vladimir Hachinski
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引用次数: 0
National approaches to reduce mortality after prison release. 降低出狱后死亡率的国家方法。
IF 25.4 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-07-01 DOI: 10.1016/S2468-2667(24)00105-1
Chrianna Bharat, Michael Farrell
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引用次数: 0
The future of public health doctoral education in Africa: transforming higher education institutions to enhance research and practice. 非洲公共卫生博士教育的未来:改革高等教育机构,加强研究与实践。
IF 25.4 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-07-01 Epub Date: 2024-05-10 DOI: 10.1016/S2468-2667(24)00056-2
Justine Bukenya, Derege Kebede, Henry Mwambi, Muhammed Pate, Philip Adongo, Yemane Berhane, Chelsey R Canavan, Tobias Chirwa, Olufunmilayo I Fawole, David Guwatudde, Elizabeth Jackson, Isabel Madzorera, Mosa Moshabela, Ayoade M J Oduola, Bruno Sunguya, Amadou Sall, Tajudeen Raji, Wafaie Fawzi

The African Union and the Africa Centers for Disease Control and Prevention issued a Call to Action in 2022 for Africa's New Public Health Order that underscored the need for increased capacity in the public health workforce. Additional domestic and global investments in public health workforce development are central to achieving the aspirations of Agenda 2063 of the African Union, which aims to build and accelerate the implementation of continental frameworks for equitable, people-centred growth and development. Recognising the crucial role of higher education and research, we assessed the capabilities of public health doctoral training in schools and programmes of public health in Africa across three conceptual components: instructional, institutional, and external. Six inter-related and actionable recommendations were derived to advance doctoral training, research, and practice capacity within and between universities. These can be achieved through equitable partnerships between universities, research centres, and national, regional, and global public health institutions.

非洲联盟和非洲疾病控制和预防中心发出了《2022 年非洲公共卫生新秩序行 动呼吁》,强调必须提高公共卫生工作人员的能力。对公共卫生人员队伍建设进行更多的国内和全球投资,对于实现非洲联盟《2063 年议程》的愿望至关重要,该议程旨在建立和加快实施非洲大陆公平、以人为本的增长和发展框架。认识到高等教育和研究的关键作用,我们从教学、机构和外部三个概念方面评估了非洲公共卫生学校和计划的公共卫生博士培训能力。为提高大学内部和大学之间的博士培训、研究和实践能力,我们提出了六项相互关联的可行建议。这些建议可以通过大学、研究中心以及国家、地区和全球公共卫生机构之间的公平伙伴关系来实现。
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引用次数: 0
Correction to Lancet Public Health 2023; 8: e1016-24. 柳叶刀公共卫生》2023;8:e1016-24 更正。
IF 25.4 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-07-01 DOI: 10.1016/S2468-2667(24)00130-0
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引用次数: 0
The 2024 Europe report of the Lancet Countdown on health and climate change: unprecedented warming demands unprecedented action. 柳叶刀健康与气候变化倒计时 2024 欧洲报告:空前的变暖需要空前的行动。
IF 25.4 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-07-01 Epub Date: 2024-05-12 DOI: 10.1016/S2468-2667(24)00055-0
Kim R van Daalen, Cathryn Tonne, Jan C Semenza, Joacim Rocklöv, Anil Markandya, Niheer Dasandi, Slava Jankin, Hicham Achebak, Joan Ballester, Hannah Bechara, Thessa M Beck, Max W Callaghan, Bruno M Carvalho, Jonathan Chambers, Marta Cirah Pradas, Orin Courtenay, Shouro Dasgupta, Matthew J Eckelman, Zia Farooq, Peter Fransson, Elisa Gallo, Olga Gasparyan, Nube Gonzalez-Reviriego, Ian Hamilton, Risto Hänninen, Charles Hatfield, Kehan He, Aleksandra Kazmierczak, Vladimir Kendrovski, Harry Kennard, Gregor Kiesewetter, Rostislav Kouznetsov, Hedi Katre Kriit, Alba Llabrés-Brustenga, Simon J Lloyd, Martín Lotto Batista, Carla Maia, Jaime Martinez-Urtaza, Zhifu Mi, Carles Milà, Jan C Minx, Mark Nieuwenhuijsen, Julia Palamarchuk, Dafni Kalatzi Pantera, Marcos Quijal-Zamorano, Peter Rafaj, Elizabeth J Z Robinson, Nacho Sánchez-Valdivia, Daniel Scamman, Oliver Schmoll, Maquins Odhiambo Sewe, Jodi D Sherman, Pratik Singh, Elena Sirotkina, Henrik Sjödin, Mikhail Sofiev, Balakrishnan Solaraju-Murali, Marco Springmann, Marina Treskova, Joaquin Triñanes, Eline Vanuytrecht, Fabian Wagner, Maria Walawender, Laura Warnecke, Ran Zhang, Marina Romanello, Josep M Antó, Maria Nilsson, Rachel Lowe
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引用次数: 0
Correction to Lancet Public Health 2024; 9: e407-10. 柳叶刀公共卫生》2024;9:e407-10 更正。
IF 25.4 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-07-01 Epub Date: 2024-05-31 DOI: 10.1016/S2468-2667(24)00121-X
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引用次数: 0
Smoking prevalence following tobacco tax increases in Australia - Authors' reply. 澳大利亚提高烟草税后的吸烟率--作者回复。
IF 25.4 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-07-01 DOI: 10.1016/S2468-2667(24)00095-1
Sarah Durkin, Michelle Scollo, Melanie Wakefield
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引用次数: 0
Smoking prevalence following tobacco tax increases in Australia. 澳大利亚提高烟草税后的吸烟率。
IF 25.4 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-07-01 DOI: 10.1016/S2468-2667(24)00094-X
Edward Jegasothy, Francis Markham
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引用次数: 0
Proactive surveillance for avian influenza H5N1 and other priority pathogens at mass gathering events. 在大规模集会活动中主动监测禽流感 H5N1 和其他重点病原体。
IF 5 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-01 Epub Date: 2024-05-16 DOI: 10.1016/S2468-2667(24)00103-8
Ziad A Memish, Rana F Kattan, Shahul H Ebrahim, Avinash Sharma, Esam I Azhar, Alimuddin Zumla
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Lancet Public Health
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