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Preparation of anterolateral thigh flap from polio-affected lower limb: A safe surgical option that preserves patient's motor function. 制备脊髓灰质炎下肢大腿前外侧皮瓣:一种安全的手术选择,可保留患者的运动功能。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2025-01-14 DOI: 10.1016/j.jormas.2025.102233
Zi-Jie Yuan, Lei Chen, Xiao-Xia Cheng, Xing-Chi Liu, Liang Mao, Jing Li, Zi-Li Yu, Jun Jia

The anterolateral thigh (ALT) flap is a commonly used donor site for reconstructive surger, especially in head and neck reconstructions. The flap's success is primarily determined by the quality and quantity of its perforating vessels, which is why clinicians typically prefer harvesting from a healthy leg with intact vascular anatomy. Poliomyelitis typically causes unilateral lower limb paralysis, resulting in muscle atrophy and deformities. Harvesting the ALT flap from the paralyzed leg could preserve the function of the unaffected limb, but this approach is complicated by the atrophy and deformities present in the affected leg, creating substantial challenges. We here report the successful ALT flap harvesting from the polio-affected leg in a 55-year-old male patient for the reconstruction of a tongue defect. The patient diagnosed with Left tongue squamous cell carcinoma, and underwent tongue cancer excision and a modified radical neck dissection. The flap survived and healed well with the patient's tongue tissue. The wound at the donor site on the thigh also healed well. There were no complications observed in either the flap or the donor site. Our experience suggests that harvesting from the paralyzed leg is a safe and feasible procedure that preserves the function of the unaffected limb and may enhance the postoperative quality of life for polio survivors.

股骨前外侧皮瓣是重建手术中常用的供体部位,尤其是头颈部重建。皮瓣的成功主要取决于其穿孔血管的质量和数量,这就是为什么临床医生通常更喜欢从血管解剖完整的健康腿上采集。脊髓灰质炎通常会引起单侧下肢瘫痪,导致肌肉萎缩和畸形。从瘫痪的腿上获取ALT皮瓣可以保留未受影响的肢体的功能,但这种方法由于受影响的腿上存在的萎缩和畸形而变得复杂,带来了巨大的挑战。我们在此报告一例55岁男性患脊髓灰质炎的患者,在舌部缺损的重建中成功获取ALT皮瓣。患者被诊断为左舌鳞状细胞癌,并接受舌癌切除和改良的根治性颈部清扫术。皮瓣存活下来,并与患者的舌头组织愈合良好。大腿供体部位的伤口也愈合得很好。皮瓣及供区均无并发症发生。我们的经验表明,从瘫痪的腿上摘取器官是一种安全可行的手术,可以保留未受影响肢体的功能,并可以提高脊髓灰质炎幸存者的术后生活质量。
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引用次数: 0
Y-shaped venous anastomosis combined with free flap for the treatment of complex craniofacial trauma. y型静脉吻合术联合游离皮瓣治疗复杂颅面外伤。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2025-01-14 DOI: 10.1016/j.jormas.2024.102203
Chenglan Yang, Lingli Jiang, Dapeng Zhou, Qi Wang, Zairong Wei

Background: Complex craniofacial trauma is defined as those traumatic injuries that are not responding to initial treatment and may involve chronic infection, tissue exposure, and soft tissue contusions. Typical reconstruction using a Y-shaped microvascular venous anastomotic free flap is labor intensive. Although free flap grafts have been used in many applications, their use for combined microvascular anastomotic therapy remains an unexplored but attractive possibility.

Purpose: Correcting facial contour trauma is challenging because it requires careful planning of flap design, composition, and ancillary procedures METHODS: This study analyzed a retrospective cohort of 28 craniofacial trauma patients (18 males; 10 females) who underwent Y-shaped microvascular venous anastomosis free flap grafting for treatment of the defects between January 2020 and January 2022, and were followed up for more than 6 months after the procedure.

Results: The causes of defects were high-voltage electrical injuries (n = 12), after excision of scalp malignant tumors (n = 8), grade III burns (n = 6), and trauma (n = 2). By adjusting the height of the tissue and the different tissue components, the flaps were designed in three dimensions by contour mapping so that they had different thicknesses depending on the defect. Custom-sized flaps with a reliable envelope were taken while minimizing the loss of overlying skin. 6 flaps were based on two perforators, and another 19 were based on one perforator. Nine flaps were harvested in an inlay fashion. All flaps were fully viable and no donor lesions were present in any case. Contour and symmetry were improved in all patients, and all grafted patients were evaluated for pre- and postoperative aesthetic restoration.

Conclusions: Our findings suggest that the Y-shaped microvascular venous anastomosis free flap approach may be a reliable alternative for aesthetic reconstruction of facial contour trauma.

背景:复杂颅面创伤被定义为那些最初治疗无效的创伤性损伤,可能包括慢性感染、组织暴露和软组织挫伤。典型的使用y形微血管静脉吻合口自由皮瓣重建是劳动密集型的。虽然游离皮瓣移植已经在许多应用中得到应用,但它们在联合微血管吻合治疗中的应用仍然是一个未被探索但很有吸引力的可能性。目的:纠正面部轮廓创伤是具有挑战性的,因为需要仔细规划皮瓣的设计、组成和辅助手术方法:本研究分析了28例颅面创伤患者(18例男性;选取2020年1月至2022年1月间行y型微血管静脉吻合口游离皮瓣移植治疗缺损的10例女性患者,术后随访6个月以上。结果:造成缺损的原因有:高压电损伤(n = 12)、头皮恶性肿瘤切除后(n = 8)、三级烧伤(n = 6)、外伤(n = 2)。通过调整组织高度和不同组织成分,采用等高线映射法对皮瓣进行三维设计,使其根据缺损具有不同的厚度。定制尺寸的皮瓣采用可靠的信封,同时最大限度地减少覆盖皮肤的损失。6个皮瓣基于两个穿孔,另外19个皮瓣基于一个穿孔。以镶嵌方式收获9个皮瓣。所有皮瓣均完全存活,无供体病变。所有患者的轮廓和对称性均得到改善,并对所有移植患者进行术前和术后美学恢复评估。结论:y型微血管静脉吻合自由皮瓣入路是一种可靠的面部轮廓外伤美学重建方法。
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引用次数: 0
The effect of the guide hole height on the accuracy of implant placement: An in-vitro study. 引导孔高度对种植体植入精度的影响:一项体外研究。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2025-01-13 DOI: 10.1016/j.jormas.2025.102232
Soohyeon Kim, Jin-Yong Cho, Jaeyoung Ryu

Objective: Guided implant surgery using three-dimensional (3-D) planning software and 3-D printed surgical guides has become a critical tool for enhancing accuracy. This study aims to determine the minimum guide hole height necessary to maintain implant placement accuracy.

Materials and methods: Ten maxillary models with edentulous areas were created using CT and optical scan data. Six sites (for each model) were prepared for implant placement with surgical guides fabricated using a 3-D printer. Sixty implants were placed using these guides and divided into five groups according to the guide hole height (1 to 5 mm). After the placement, digital impressions were taken to assess the accuracy of implant positioning. Deviations between planned and actual implant positions were investigated using computer software, and data were statistically analyzed using ANOVA and Kruskal-Wallis tests.

Results: Guide holes with 1 mm height (Group Ⅰ) resulted in the highest 3-D deviations (1.12 ± 0.36 and 1.99 ± 0.74 mm at the coronal and apical positions, respectively), with significant errors at the implant apical position compared to groups with taller guide holes (Groups Ⅳ and Ⅴ) (p = 0.005). There were no significant deviations between the 3 mm and 5 mm guide hole heights, with no statistical differences between groups at the x, y, and z-axis in the implant position.

Conclusion: A comparison between the group with a guide hole height of 5 mm on one side and the group with a height of 1 mm on both sides revealed a significant difference in implant placement accuracy.

目的:三维(3-D)规划软件和3-D打印手术导板的应用已成为提高手术精度的重要工具。本研究旨在确定维持种植体放置精度所需的最小导孔高度。材料与方法:利用CT和光学扫描资料制作10个上颌无牙区模型。使用3d打印机制作手术导板,为每个模型准备6个部位进行植入。使用这些导孔放置60个种植体,根据导孔高度(1 ~ 5mm)分为5组。放置后,采用数字印模来评估种植体定位的准确性。使用计算机软件调查计划种植体位置与实际种植体位置之间的偏差,并使用方差分析和Kruskal-Wallis检验对数据进行统计分析。结果:1 mm高的导孔(Ⅰ组)在冠状位和根尖位的三维误差最高(分别为1.12±0.36和1.99±0.74 mm),在种植体根尖位置的三维误差与高导孔组(Ⅳ组和Ⅴ组)相比有显著性差异(p = 0.005)。3 mm与5 mm导孔高度差异无统计学意义,组间种植体位置x、y、z轴差异无统计学意义。结论:单侧导孔高度为5mm组与双侧导孔高度为1mm组比较,种植体植入精度有显著差异。
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引用次数: 0
Ischemic preconditioning in arterialized venous flap: Temperature effects and monitoring. 动脉化静脉瓣缺血预处理:温度效应和监测。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2025-01-12 DOI: 10.1016/j.jormas.2025.102231
Rani Septrina, Ronny Lesmana, Reno Rudiman, Rizky Abdullah, Irra R Widarda, Ita N Kusmayadi, Stevy C Suoth, Caroline Dewi

Introduction: Arterialized venous flap, like any other flap, will undergo an ischemic reperfusion injury during its transfer process. To overcome this, ischemic preconditioning can be done to provide protection and enhanced flap survival. One of the reliable parameters of flap survival is its temperature. However, there was no recorded data regarding AVF's temperature or its monitoring. This research aimed to demonstrate the temperature effect of ischemic preconditioning on arterialized venous flap.

Method: Male Wistar Rats were randomly divided into 4 groups, consisting of 6 negative control groups, 8 positive control group (PS) rats that underwent an anastomosis of the superficial epigastric artery to the superficial epigastric vein, 8 experimental rat group 1 (EX1) that underwent 3 cycles of 5 minutes pre-anastomosis clamping with 3 cycles of 5 minutes each, and 8 experimental rats' group 2 (EX2) with 3 cycles of 10 minutes. Flap's temperature was observed preoperatively and postoperatively from day 1 to day 7, day 14, and day 21 with an android-based thermal camera and recorded in Celsius degrees.

Results: All the flaps (N= 26) were vital. The temperature drop was seen in all anastomosed flaps compared to the negative control (30.37 vs. 25.08 vs. 23.77 vs. 25.27, p<0.05). A significant increase in temperature occurred on days 4 to 6 in Ex1 (33.62±1.820, 33.62±1.820, 32.40±1.627; p<0.05). As in the temperature trend, Ex2 is shown to have a stable temperature from day 2 until 21.

Conclusion: This study has recorded an increase in temperature in the early days of the creation of the arterialized venous flap at various timings of ischemic preconditioning. The flap's monitoring was easily observed with a thermal camera that can be implemented in humans.

简介动脉化静脉皮瓣与其他皮瓣一样,在转移过程中会发生缺血再灌注损伤。为克服这一问题,可进行缺血预处理,以提供保护并提高皮瓣存活率。皮瓣存活的可靠参数之一是温度。然而,目前还没有关于 AVF 温度或其监测的记录数据。本研究旨在证明缺血预处理对动脉静脉皮瓣温度的影响:雄性 Wistar 大鼠随机分为 4 组,包括 6 只阴性对照组、8 只阳性对照组(PS)大鼠(进行了上浅动脉与上浅静脉的吻合术)、8 只实验鼠 1 组(EX1)(进行了 3 次 5 分钟的吻合前夹闭,每次 5 分钟)和 8 只实验鼠 2 组(EX2)(进行了 3 次 10 分钟的吻合前夹闭,每次 10 分钟)。术前和术后第 1 天至第 7 天、第 14 天和第 21 天使用安卓热像仪观察皮瓣温度,并以摄氏度为单位进行记录:结果:所有皮瓣(26 个)均有生命体征。与阴性对照组相比,所有吻合皮瓣的温度都有所下降(30.37 vs. 25.08 vs. 23.77 vs. 25.27,p):本研究记录了在缺血预处理的不同时间段,动脉化静脉皮瓣制作初期的温度升高情况。使用热像仪很容易观察到皮瓣的监测情况,这种热像仪可以在人体中使用。
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引用次数: 0
Predictor of diplopia in pure orbital blowout fracture: A 14-year retrospective analysis. 单纯眼眶爆裂骨折复视的预测因素:14年回顾性分析。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2025-01-12 DOI: 10.1016/j.jormas.2025.102230
Mohd Ferdaus Isa, Abd Jabar Nazimi, Roszalina Ramli

Introduction: Orbital fractures are common among maxillofacial injuries. The primary objective of this study was to investigate the clinical and radiographic characteristics of pure orbital blowout fractures (OBFs) and their association with post-traumatic diplopia. The secondary objective was to identify predictors of diplopia in pure OBFs.

Method: This retrospective cross-sectional study analysed the clinical records and computed tomography (CT) data of patients with pure OBFs, treated between 1st January 2008 and 28th February 2022 at a single tertiary trauma centre in Klang Valley, Kuala Lumpur, Malaysia. Data collected included demographic characteristics and the aetiology of OBFs. Specific factors such as fracture site, size, type, and soft tissue involvement were assessed using CT images, which were converted to DICOM format and analysed with the OsiriX v4.1.2 software. Diplopia was measured using the Hess area ratio percentage (HAR%).

Results: The analysis included records of 70 patients. Motor vehicle accidents (MVAs) accounted for 61.4 % of pure OBFs. The largest fracture observed involved both the orbital floor and the medial wall, with a mean size of 6.40 ± 3.05 cm². Among the patients, 41.6 % had Type 3 fractures, and 50 % (n = 35) had 2-point muscle-soft tissue contact. Fracture size, site, type, and muscle contact were all significantly associated with HAR92 % (p < 0.05). Logistic regression revealed that Type 3 fracture was the significant predictor of diplopia (HAR < 92 %), with an odds ratio of 19.80 (95 % CI: 5.76-68.07, p < 0.001).

Conclusion: Fracture site, size, type, and muscle involvement were important factors associated with diplopia. Among these, Type 3 fractures were identified as the primary predictor of HAR < 92 %.

眶部骨折是颌面部外伤中常见的一种。本研究的主要目的是探讨单纯眼眶爆裂骨折(OBFs)的临床和影像学特征及其与创伤后复视的关系。次要目的是确定纯obf复视的预测因素。方法:本回顾性横断面研究分析了2008年1月1日至2022年2月28日在马来西亚吉隆坡巴生谷单一三级创伤中心治疗的纯OBFs患者的临床记录和计算机断层扫描(CT)数据。收集的数据包括人口统计学特征和obf的病因学。使用CT图像评估骨折部位、大小、类型和软组织受损伤等具体因素,并将其转换为DICOM格式,使用OsiriX v4.1.2软件进行分析。复视测量采用赫斯面积比百分比(Hess area ratio percentage, HAR%)。结果:分析纳入70例患者的记录。机动车事故(MVAs)占纯obf的61.4%。最大的骨折累及眶底和内侧壁,平均大小为6.40±3.05 cm²。其中41.6%为3型骨折,50% (n = 35)为2点肌-软组织接触。骨折的大小、部位、类型和肌肉接触均与HAR92%有显著相关(p < 0.05)。Logistic回归分析显示,3型骨折是复视的显著预测因子(HAR < 92%),比值比为19.80 (95% CI: 5.76 ~ 68.07, p < 0.001)。结论:骨折部位、大小、类型和肌肉受累程度是复视发生的重要因素。其中,3型骨折被确定为HAR的主要预测因子< 92%。
{"title":"Predictor of diplopia in pure orbital blowout fracture: A 14-year retrospective analysis.","authors":"Mohd Ferdaus Isa, Abd Jabar Nazimi, Roszalina Ramli","doi":"10.1016/j.jormas.2025.102230","DOIUrl":"10.1016/j.jormas.2025.102230","url":null,"abstract":"<p><strong>Introduction: </strong>Orbital fractures are common among maxillofacial injuries. The primary objective of this study was to investigate the clinical and radiographic characteristics of pure orbital blowout fractures (OBFs) and their association with post-traumatic diplopia. The secondary objective was to identify predictors of diplopia in pure OBFs.</p><p><strong>Method: </strong>This retrospective cross-sectional study analysed the clinical records and computed tomography (CT) data of patients with pure OBFs, treated between 1st January 2008 and 28th February 2022 at a single tertiary trauma centre in Klang Valley, Kuala Lumpur, Malaysia. Data collected included demographic characteristics and the aetiology of OBFs. Specific factors such as fracture site, size, type, and soft tissue involvement were assessed using CT images, which were converted to DICOM format and analysed with the OsiriX v4.1.2 software. Diplopia was measured using the Hess area ratio percentage (HAR%).</p><p><strong>Results: </strong>The analysis included records of 70 patients. Motor vehicle accidents (MVAs) accounted for 61.4 % of pure OBFs. The largest fracture observed involved both the orbital floor and the medial wall, with a mean size of 6.40 ± 3.05 cm². Among the patients, 41.6 % had Type 3 fractures, and 50 % (n = 35) had 2-point muscle-soft tissue contact. Fracture size, site, type, and muscle contact were all significantly associated with HAR92 % (p < 0.05). Logistic regression revealed that Type 3 fracture was the significant predictor of diplopia (HAR < 92 %), with an odds ratio of 19.80 (95 % CI: 5.76-68.07, p < 0.001).</p><p><strong>Conclusion: </strong>Fracture site, size, type, and muscle involvement were important factors associated with diplopia. Among these, Type 3 fractures were identified as the primary predictor of HAR < 92 %.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102230"},"PeriodicalIF":2.2,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The "HAT-TRICK" technique: A modification of soft tissue grafting using volume stable collagen matrix and cross-linked hyaluronic acid. Part B: Clinical applications in the esthetic zone. “帽子戏法”技术:使用体积稳定的胶原基质和交联透明质酸进行软组织移植的改良。B部分:美学领域的临床应用。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2025-01-11 DOI: 10.1016/j.jormas.2025.102229
Bachar Husseini, Anton Friedmann, Marwan El Mobadder, Nabil Ghosn, Karim Senni, Ranim Abou Chakra, Patrick El Sayegh, Ronald Younes

Soft tissue deficiency around dental implants can negatively impact outcomes in terms of esthetics and long-term stability. While autogenous connective tissue grafting is still considered the gold standard treatment, alternative approaches are being proposed primarily to enhance patient comfort and avoid invasive procedures such as two-sites surgeries using xenogeneic collagen matrices. Despite the advantages, the quality of the regenerated tissues remains unpredictable and, in many cases, questionable, highlighting the need for alternative and innovative approaches. After introducing in a previous technical note, the "HAT-TRICK" technique, to address these challenges in pontic sites, the present study highlights the "HAT-TRICK" technique for thickening the keratinized gingiva in both immediate and delayed implant placement sites within the esthetic zone. The "HAT-TRICK" technique is demonstrated through two clinical cases, accompanied by a digital comparison conducted at baseline and after one year of follow-up in order to assess and quantify the augmented areas.

种植体周围的软组织缺损会对美观和长期稳定性产生负面影响。虽然自体结缔组织移植仍然被认为是金标准治疗,但替代方法主要是为了提高患者的舒适度,避免侵入性手术,如使用异种胶原基质的两部位手术。尽管有这些优势,但再生组织的质量仍然不可预测,在许多情况下,值得怀疑,这突出了对替代和创新方法的需求。在之前的技术说明中介绍了“HAT-TRICK”技术,以解决桥桥部位的这些挑战,本研究强调了“HAT-TRICK”技术,用于在美学区域内立即和延迟种植体放置部位增厚角化牙龈。“帽子戏法”技术通过两个临床病例进行演示,并在基线和一年随访后进行数字比较,以评估和量化增强区域。
{"title":"The \"HAT-TRICK\" technique: A modification of soft tissue grafting using volume stable collagen matrix and cross-linked hyaluronic acid. Part B: Clinical applications in the esthetic zone.","authors":"Bachar Husseini, Anton Friedmann, Marwan El Mobadder, Nabil Ghosn, Karim Senni, Ranim Abou Chakra, Patrick El Sayegh, Ronald Younes","doi":"10.1016/j.jormas.2025.102229","DOIUrl":"10.1016/j.jormas.2025.102229","url":null,"abstract":"<p><p>Soft tissue deficiency around dental implants can negatively impact outcomes in terms of esthetics and long-term stability. While autogenous connective tissue grafting is still considered the gold standard treatment, alternative approaches are being proposed primarily to enhance patient comfort and avoid invasive procedures such as two-sites surgeries using xenogeneic collagen matrices. Despite the advantages, the quality of the regenerated tissues remains unpredictable and, in many cases, questionable, highlighting the need for alternative and innovative approaches. After introducing in a previous technical note, the \"HAT-TRICK\" technique, to address these challenges in pontic sites, the present study highlights the \"HAT-TRICK\" technique for thickening the keratinized gingiva in both immediate and delayed implant placement sites within the esthetic zone. The \"HAT-TRICK\" technique is demonstrated through two clinical cases, accompanied by a digital comparison conducted at baseline and after one year of follow-up in order to assess and quantify the augmented areas.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102229"},"PeriodicalIF":2.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the greater palatine foramen, the greater palatine artery, and palatal fibromucosa: A cross-sectional ultrasonographic clinical study. 鉴定腭大孔、腭大动脉和腭纤维粘膜:横断面超声临床研究。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2025-01-11 DOI: 10.1016/j.jormas.2025.102228
Kubra Torenek Agirman, Fatma Caglayan

Objectives: This study aimed to evaluate with ultrasonography (US) the location of GPF, the course of the GPA, and to measure palatal fibromucosa thickness.

Materials and methods: This in vivo experiment was conducted on a group of healthy, young Turkish subjects. Using the US, the localization of the GPF, its diameter and opening type, maximum flow velocity (Vmax) and collateral branches (CB) of the GPA, and the thickness of the palatine mucosa were evaluated. The distance between the probe and the gingival margin (GM-P) was also measured to determine the course of GPA. Statistical analyses were performed using the chi-square test and the independent sample t-test, with the significance level set at 0.05.

Results: The study included 31 participants (16 females, 15 males; mean age, 23.77±0.92). GPF predominantly showed between the second and third molars (n = 15;48.4 %) and exhibited an anterior opening type(n = 25;80.6 %). The average diameter of GPF measured 5.52±1.76 mm, with a Vmax value of GPA at 14.39±5.07 cm/sec. Collateral branches were primarily observed at the first molar level (n = 23; 74.2 %). No statistically significant gender differences were noted in localization or opening type. However, GM-P at the second molar level was significantly greater in men than women(p < 0.05).

Conclusion: In understanding the anatomical structure of the palate, the US provides important clinical results regarding the anatomical measurement of the GPF, the GPA, and adjacent fibromucosa.

目的:本研究旨在通过超声(US)评估GPF的位置、病程,并测量腭纤维粘膜厚度。材料和方法:本实验在一组健康的年轻土耳其受试者身上进行。应用超声技术,评估GPF的定位、直径和开口类型、GPF的最大流速(Vmax)和侧支(CB)以及腭黏膜的厚度。同时测量探针与龈缘之间的距离(GM-P),以确定GPA的进程。采用卡方检验和独立样本t检验进行统计学分析,显著性水平为0.05。结果:共纳入31名受试者(女性16人,男性15人;平均年龄(23.77±0.92)。GPF主要发生在第二磨牙和第三磨牙之间(n=15, 48.4%),表现为前开型(n=25, 80.6%)。GPF的平均直径为5.52±1.76 mm, Vmax为14.39±5.07 cm/sec。侧枝主要在第一磨牙水平观察到(n=23;74.2%)。在定位和开口类型上,性别差异无统计学意义。然而,第二磨牙水平的GM-P在男性中明显高于女性(p结论:在了解上颚的解剖结构方面,美国在GPF、GPA和邻近纤维粘膜的解剖测量方面提供了重要的临床结果。
{"title":"Identification of the greater palatine foramen, the greater palatine artery, and palatal fibromucosa: A cross-sectional ultrasonographic clinical study.","authors":"Kubra Torenek Agirman, Fatma Caglayan","doi":"10.1016/j.jormas.2025.102228","DOIUrl":"10.1016/j.jormas.2025.102228","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate with ultrasonography (US) the location of GPF, the course of the GPA, and to measure palatal fibromucosa thickness.</p><p><strong>Materials and methods: </strong>This in vivo experiment was conducted on a group of healthy, young Turkish subjects. Using the US, the localization of the GPF, its diameter and opening type, maximum flow velocity (Vmax) and collateral branches (CB) of the GPA, and the thickness of the palatine mucosa were evaluated. The distance between the probe and the gingival margin (GM-P) was also measured to determine the course of GPA. Statistical analyses were performed using the chi-square test and the independent sample t-test, with the significance level set at 0.05.</p><p><strong>Results: </strong>The study included 31 participants (16 females, 15 males; mean age, 23.77±0.92). GPF predominantly showed between the second and third molars (n = 15;48.4 %) and exhibited an anterior opening type(n = 25;80.6 %). The average diameter of GPF measured 5.52±1.76 mm, with a Vmax value of GPA at 14.39±5.07 cm/sec. Collateral branches were primarily observed at the first molar level (n = 23; 74.2 %). No statistically significant gender differences were noted in localization or opening type. However, GM-P at the second molar level was significantly greater in men than women(p < 0.05).</p><p><strong>Conclusion: </strong>In understanding the anatomical structure of the palate, the US provides important clinical results regarding the anatomical measurement of the GPF, the GPA, and adjacent fibromucosa.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102228"},"PeriodicalIF":2.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the repair function of radiation-induced salivary gland injury using human amniotic mesenchymal stem cells pre treated with hypoxia. 缺氧预处理人羊膜间充质干细胞修复辐射性唾液腺损伤功能的研究。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2025-01-10 DOI: 10.1016/j.jormas.2025.102223
Yingxin Wang, Nana Liu, Xin Zhang, Min Dai, Nini Zhang, Guilin Huang

Objective: To investigate the reparative effect of hypoxia pretreated hAMSCs on radiation-induced damage to salivary gland function in mice.

Methods: hAMSCs were separated from human amniotic tissues by mechanical and enzymatic digestion methods and a 15 Gy electron beam was used to locally irradiate the neck of mouse to create a salivary gland injury model. The mouse models were randomly divided into four groups: control group, IR+PBS group, IR+Nor group and IR+HP group.

Result: Two months after hAMSCs injection, the saliva flow of mice in the IR+PBS group was significantly lower than that of the control group (P < 0.05). The saliva flow of mice in the IR+Nor group and IR+HP group were significantly increased compared to the IR+PBS group (P < 0.05). The cell apoptosis rate of the IR+PBS group was sensibly higher than that of the blank control group (P < 0.05). The cell apoptosis rates of the IR+Nor group and the IR+HP group were lower than that of the IR+PBS group. In addition, the apoptosis rate of the IR+HP group was lower than that of the IR+Nor group (P < 0.05). The changes of IOD of α-Amy in each group showed that the expression of α - Amy in the IR+PBS group was significantly lower than that in the blank control group (P < 0.05). Compared with the IR+PBS group, the IR+Nor group and the IR+HP group showed an obvious increase in the expression of α-Amy (P < 0.05).

Conclusion: Low oxygen pretreatment of hAMSCs could more effectively repair the function of radiation-induced salivary gland compared to normoxic cultivation.

目的:研究缺氧预处理的 hAMSCs 对小鼠唾液腺功能辐射损伤的修复作用:方法:采用机械和酶解方法从人羊膜组织中分离出hAMSCs,用15 Gy电子束局部照射小鼠颈部,建立唾液腺损伤模型。小鼠模型随机分为四组:对照组、IR+PBS组、IR+Nor组和IR+HP组:结果:注射 hAMSCs 两个月后,IR+PBS 组小鼠的唾液流量明显低于对照组(PC 结论:IR+PBS 组小鼠的唾液流量明显低于对照组(PC):与常氧培养相比,低氧预处理 hAMSCs 能更有效地修复辐射引起的唾液腺功能。
{"title":"Study on the repair function of radiation-induced salivary gland injury using human amniotic mesenchymal stem cells pre treated with hypoxia.","authors":"Yingxin Wang, Nana Liu, Xin Zhang, Min Dai, Nini Zhang, Guilin Huang","doi":"10.1016/j.jormas.2025.102223","DOIUrl":"10.1016/j.jormas.2025.102223","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the reparative effect of hypoxia pretreated hAMSCs on radiation-induced damage to salivary gland function in mice.</p><p><strong>Methods: </strong>hAMSCs were separated from human amniotic tissues by mechanical and enzymatic digestion methods and a 15 Gy electron beam was used to locally irradiate the neck of mouse to create a salivary gland injury model. The mouse models were randomly divided into four groups: control group, IR+PBS group, IR+Nor group and IR+HP group.</p><p><strong>Result: </strong>Two months after hAMSCs injection, the saliva flow of mice in the IR+PBS group was significantly lower than that of the control group (P < 0.05). The saliva flow of mice in the IR+Nor group and IR+HP group were significantly increased compared to the IR+PBS group (P < 0.05). The cell apoptosis rate of the IR+PBS group was sensibly higher than that of the blank control group (P < 0.05). The cell apoptosis rates of the IR+Nor group and the IR+HP group were lower than that of the IR+PBS group. In addition, the apoptosis rate of the IR+HP group was lower than that of the IR+Nor group (P < 0.05). The changes of IOD of α-Amy in each group showed that the expression of α - Amy in the IR+PBS group was significantly lower than that in the blank control group (P < 0.05). Compared with the IR+PBS group, the IR+Nor group and the IR+HP group showed an obvious increase in the expression of α-Amy (P < 0.05).</p><p><strong>Conclusion: </strong>Low oxygen pretreatment of hAMSCs could more effectively repair the function of radiation-induced salivary gland compared to normoxic cultivation.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102223"},"PeriodicalIF":2.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Condylar changes in adult patients with unilateral posterior crossbite following microimplant-assisted rapid palatal expansion: A retrospective CBCT study. 微种植体辅助腭快速扩张后成人单侧后牙合患者的髁突变化:回顾性CBCT研究。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2025-01-10 DOI: 10.1016/j.jormas.2024.102205
Bushra Sufyan ALmaqrami, Enas Senan ALyafrusee, Yinyue Luo, Ibtehal Almagrami, Abbas Ahmed Abdulqader, Najah Alhashimi, Hui Xiong, Hong He

Objectives: This study aimed to assess the alterations in condylar positioning in adult skeletal Class I patients with unilateral posterior crossbite following microimplant-assisted rapid palatal expansion (MARPE) treatment.

Methods: This retrospective study involving 30 participants (10 males, 20 females) with an average age 22.9 ± 4.2 years, ranged from 18.1 to 30.9 years, who were treated with a customized microimplant-supported rapid palatal expander. Pre-expansion and post- comprehensive orthodontic treatment CBCT images (20-26 ±2.1months) were analyzed to assess the condylar changes before and after treatment. We measured the temporomandibular joint (TMJ) in the three dimension in terms of: (1) The position and angle of the mandibular condyles; (2) How centralized the condyles were in their particular mandibular fossae; and (3) The volume of the TMJ and the joint spaces. To evaluate the differences between the T1 and T2 samples, we used the paired t-test and the Wilcoxon signed rank test.

Results: Before treatment, minor differences were noted in the anterior joint space (AJS), superior joint space (SJS), and anteroposterior condylar joint position (APCJP) between the crossbite and non-crossbite sides, though these differences were not statistically significant. Post-treatment, the condyles on both sides assumed a more posterior position, yet significant asymmetry in the AJS persisted (P < .05). The crossbite-side condyle also showed a tendency to rotate toward the non-crossbite side in the anteroposterior direction. While MARPE affected specific aspects of condylar positioning, achieving complete alignment remained challenging.

Conclusion: This study provides insightful observations on the enduring impacts of MARPE on TMJ spaces and position in adult patients suffering from a unilateral posterior crossbite.

目的:本研究旨在评估成人骨骼I类单侧后牙合患者在微种植体辅助快速腭扩张(MARPE)治疗后髁突定位的改变。方法:回顾性研究30例患者(男10例,女20例),平均年龄22.9±4.2岁,年龄(18.1 ~ 30.9岁),均采用定制化微种植体支持快速腭扩张器治疗。分析扩展前和综合正畸治疗后(20-26±2.1个月)的CBCT图像,评估治疗前后髁突的变化。我们对颞下颌关节(TMJ)进行三维测量:(1)下颌髁的位置、角度和倾斜度;(2)髁突在其特定的下颌窝的集中程度;(3) TMJ和TMJ空间的体积。为了评估T1和T2样本之间的差异,我们使用配对t检验和Wilcoxon符号秩检验。结果:治疗前,牙合侧与非牙合侧的前关节间隙(AJS)、上关节间隙(SJS)、髁突前后关节位置(APCJP)有轻微差异,但差异无统计学意义。治疗后,两侧髁突位置更靠后,但AJS明显不对称仍然存在(P < 0.05)。牙合侧髁也有向非牙合侧前后方向旋转的趋势。虽然MARPE影响了髁突定位的特定方面,但实现完全对齐仍然具有挑战性。结论:本研究对成人单侧后牙合患者的颞下颌关节间隙和位置的持久影响提供了深刻的观察。
{"title":"Condylar changes in adult patients with unilateral posterior crossbite following microimplant-assisted rapid palatal expansion: A retrospective CBCT study.","authors":"Bushra Sufyan ALmaqrami, Enas Senan ALyafrusee, Yinyue Luo, Ibtehal Almagrami, Abbas Ahmed Abdulqader, Najah Alhashimi, Hui Xiong, Hong He","doi":"10.1016/j.jormas.2024.102205","DOIUrl":"10.1016/j.jormas.2024.102205","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the alterations in condylar positioning in adult skeletal Class I patients with unilateral posterior crossbite following microimplant-assisted rapid palatal expansion (MARPE) treatment.</p><p><strong>Methods: </strong>This retrospective study involving 30 participants (10 males, 20 females) with an average age 22.9 ± 4.2 years, ranged from 18.1 to 30.9 years, who were treated with a customized microimplant-supported rapid palatal expander. Pre-expansion and post- comprehensive orthodontic treatment CBCT images (20-26 ±2.1months) were analyzed to assess the condylar changes before and after treatment. We measured the temporomandibular joint (TMJ) in the three dimension in terms of: (1) The position and angle of the mandibular condyles; (2) How centralized the condyles were in their particular mandibular fossae; and (3) The volume of the TMJ and the joint spaces. To evaluate the differences between the T1 and T2 samples, we used the paired t-test and the Wilcoxon signed rank test.</p><p><strong>Results: </strong>Before treatment, minor differences were noted in the anterior joint space (AJS), superior joint space (SJS), and anteroposterior condylar joint position (APCJP) between the crossbite and non-crossbite sides, though these differences were not statistically significant. Post-treatment, the condyles on both sides assumed a more posterior position, yet significant asymmetry in the AJS persisted (P < .05). The crossbite-side condyle also showed a tendency to rotate toward the non-crossbite side in the anteroposterior direction. While MARPE affected specific aspects of condylar positioning, achieving complete alignment remained challenging.</p><p><strong>Conclusion: </strong>This study provides insightful observations on the enduring impacts of MARPE on TMJ spaces and position in adult patients suffering from a unilateral posterior crossbite.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102205"},"PeriodicalIF":2.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four decades of treatment for actinic cheilitis: Outcomes, challenges, and the introduction of a new clinical index. 光化性口炎治疗的四十年:结果、挑战和新临床指标的引入。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2025-01-08 DOI: 10.1016/j.jormas.2025.102227
Lukas Mendes de Abreu, Talissa da Silva Medina, Nívea Layani Mariah Juliani Cruz, Izabel Regina Fisher Rubira Bullen, Cássia Maria Fisher Rubira

Objective: To evaluate the clinical outcomes of surgical and non-surgical treatments for actinic cheilitis (AC) over a four-decade period and to introduce a novel Clinical Index for the Treatment and Control of Actinic Cheilitis (CITC-AC) for improved patient stratification and management.

Materials and methods: A retrospective cohort study analyzed 151 patients diagnosed with AC treated at a university clinic between 1980 and 2020. Sociodemographic, clinical, and histopathological data were collected. Treatments were categorized as sun protection (SP), topical corticosteroids (TC), surgical removal (SR), and vermilionectomy. Therapeutic outcomes, recurrence rates, and malignant transformation were assessed. The CITC-AC was developed to guide clinical decision-making based on stratified risk.

Results: A total of 87% of patients achieved therapeutic resolution. Recurrence was observed in 13%, and malignant transformation occurred in 7% of cases. Surgical treatments, particularly vermilionectomy, demonstrated superior outcomes with no recurrence or malignancy. Non-surgical treatments, including the novel use of Omcion-A Orabase, achieved favorable outcomes but exhibited higher recurrence rates. The CITC-AC provided a structured framework for stratifying patients by severity and risk, aiding in the selection of appropriate interventions and follow-up schedules.

Conclusions: This study highlights the importance of individualized treatment strategies and consistent follow-up in AC management. While surgical interventions remain the gold standard for advanced cases, non-surgical treatments are effective for early-stage lesions. The CITC-AC offers a practical tool for optimizing patient care and reducing progression to squamous cell carcinoma (SCC). Prospective studies are needed to validate its applicability across diverse clinical settings.

目的:评价近40年来光化性口炎(AC)手术和非手术治疗的临床效果,并提出一种新的光化性口炎治疗和控制临床指标(CITC-AC),以改善患者分层和管理。材料和方法:一项回顾性队列研究分析了1980年至2020年间在一所大学诊所接受治疗的151名确诊为AC的患者。收集了社会人口学、临床和组织病理学数据。治疗方法分为防晒(SP)、外用皮质类固醇(TC)、手术切除(SR)和朱砂切除术。评估治疗结果、复发率和恶性转化。CITC-AC的开发是为了指导基于分层风险的临床决策。结果:87%的患者获得治疗缓解。复发率为13%,恶性转化率为7%。手术治疗,特别是朱砂切除术,表现出良好的预后,无复发或恶性肿瘤。非手术治疗,包括新使用的Omcion-A Orabase,取得了良好的结果,但表现出较高的复发率。CITC-AC提供了一个结构化的框架,根据严重程度和风险对患者进行分层,有助于选择适当的干预措施和随访计划。结论:本研究强调了个体化治疗策略和持续随访在AC治疗中的重要性。虽然手术干预仍然是晚期病例的金标准,但非手术治疗对早期病变有效。CITC-AC为优化患者护理和减少鳞状细胞癌(SCC)的进展提供了一个实用的工具。需要前瞻性研究来验证其在不同临床环境中的适用性。
{"title":"Four decades of treatment for actinic cheilitis: Outcomes, challenges, and the introduction of a new clinical index.","authors":"Lukas Mendes de Abreu, Talissa da Silva Medina, Nívea Layani Mariah Juliani Cruz, Izabel Regina Fisher Rubira Bullen, Cássia Maria Fisher Rubira","doi":"10.1016/j.jormas.2025.102227","DOIUrl":"10.1016/j.jormas.2025.102227","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical outcomes of surgical and non-surgical treatments for actinic cheilitis (AC) over a four-decade period and to introduce a novel Clinical Index for the Treatment and Control of Actinic Cheilitis (CITC-AC) for improved patient stratification and management.</p><p><strong>Materials and methods: </strong>A retrospective cohort study analyzed 151 patients diagnosed with AC treated at a university clinic between 1980 and 2020. Sociodemographic, clinical, and histopathological data were collected. Treatments were categorized as sun protection (SP), topical corticosteroids (TC), surgical removal (SR), and vermilionectomy. Therapeutic outcomes, recurrence rates, and malignant transformation were assessed. The CITC-AC was developed to guide clinical decision-making based on stratified risk.</p><p><strong>Results: </strong>A total of 87% of patients achieved therapeutic resolution. Recurrence was observed in 13%, and malignant transformation occurred in 7% of cases. Surgical treatments, particularly vermilionectomy, demonstrated superior outcomes with no recurrence or malignancy. Non-surgical treatments, including the novel use of Omcion-A Orabase, achieved favorable outcomes but exhibited higher recurrence rates. The CITC-AC provided a structured framework for stratifying patients by severity and risk, aiding in the selection of appropriate interventions and follow-up schedules.</p><p><strong>Conclusions: </strong>This study highlights the importance of individualized treatment strategies and consistent follow-up in AC management. While surgical interventions remain the gold standard for advanced cases, non-surgical treatments are effective for early-stage lesions. The CITC-AC offers a practical tool for optimizing patient care and reducing progression to squamous cell carcinoma (SCC). Prospective studies are needed to validate its applicability across diverse clinical settings.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102227"},"PeriodicalIF":2.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Stomatology Oral and Maxillofacial Surgery
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