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VIRTUAL SURGICAL PLANNING AND 3D CUSTOM-MADE IMPLANTS IN THE MANAGEMENT OF ORBITAL FLOOR FRACTURES: A CASE CONTROL STUDY. 虚拟手术计划和三维定制植入物在眶底骨折治疗中的应用:一个病例对照研究。
IF 2 3区 医学 Q2 Dentistry Pub Date : 2026-01-14 DOI: 10.1016/j.jormas.2026.102718
Stefania Troise, Federica Calabria, Raffaele Spinelli, Silvia De Masi, Sara Tramontano, Vincenzo Abbate, Paola Bonavolontà, Giovanni Salzano, Gianluca Renato De Fazio, Antonio Romano, Luigi Angelo Vaira, Giuseppe Consorti, Carlos Navarro Cuellar, Giovanni Dell'Aversana Orabona

Background: Orbital floor fractures are among the most frequent facial injuries, and precise reconstruction is essential to prevent both functional and aesthetic complications. Virtual Surgical Planning (VSP) combined with pre-shaped titanium mesh has transformed orbital reconstruction. This study aimed to evaluate whether VSP-assisted surgery with pre-modeled mesh provides greater accuracy and reduced operative times compared with conventional intraoperative mesh shaping.

Methods: A case-control study was performed on 52 patients treated at the "Federico II" University Hospital of Naples for large pure orbital floor fractures. Twenty-four patients (Group A) underwent VSP-assisted reconstruction using a preformed titanium mesh, while twenty-eight patients (Group B) received conventional intraoperative mesh modeling. Operative time, postoperative diplopia, infraorbital sensory disturbance, mesh malposition, screw loosening, and infection were compared in the two groups. Clinical and radiological follow-up was conducted at 12 months.

Results: Median operative time was significantly shorter in Group A compared with Group B (55 minutes [IQR 50-65] vs. 110 minutes [IQR 98-125]; p < 0.001). Persistent diplopia occurred in 4% of patients in Group A and 28.6% in Group B (p = 0.028). Implant malposition was observed exclusively in Group B (25% vs. 0%; p = 0.011). Other postoperative complications, including infraorbital nerve alterations, eyelid malposition, wound dehiscence, screw loss, and infection, were more frequent in Group B but did not reach statistical significance. No cases of postoperative ocular motility limitation or iatrogenic fracture were observed in either group.

Conclusions: VSP with pre-modeled titanium mesh significantly reduces operative time and postoperative complications, enhancing reconstructive precision and outcomes in orbital floor fracture management. This virtual protocol is useful for reducing the costs and waiting times of custom-made implants, manufactured by external companies.

背景:眶底骨折是最常见的面部损伤之一,精确的重建是防止功能和美学并发症的必要条件。虚拟手术计划(VSP)结合预成形钛网改造眼眶重建。本研究旨在评估与传统的术中补片成形相比,使用预建模补片的vsp辅助手术是否提供更高的准确性和更少的手术时间。方法:对那不勒斯“Federico II”大学医院收治的52例单纯眶底大骨折患者进行病例对照研究。24例患者(A组)采用预成型钛网进行vsp辅助重建,28例患者(B组)采用常规术中补片建模。比较两组手术时间、术后复视、眶下感觉障碍、补片错位、螺钉松动、感染情况。12个月后进行临床及影像学随访。结果:A组中位手术时间明显短于B组(55分钟[IQR 50-65] vs 110分钟[IQR 98-125]; p < 0.001)。A组持续复视发生率为4%,B组为28.6% (p = 0.028)。B组仅出现种植体错位(25% vs. 0%; p = 0.011)。B组术后其他并发症眶下神经改变、眼睑错位、创面裂开、螺钉脱落、感染发生率较高,但无统计学意义。两组均无术后眼动受限或医源性骨折发生。结论:预模钛网VSP可显著减少手术时间和术后并发症,提高眶底骨折重建精度和治疗效果。这种虚拟协议有助于减少由外部公司制造的定制植入物的成本和等待时间。
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引用次数: 0
Biomechanical evaluation of reconstruction plates in bone-grafted mandibular defects: a finite element analysis. 骨移植下颌骨缺损重建钢板的生物力学评价:有限元分析。
IF 2 3区 医学 Q2 Dentistry Pub Date : 2026-01-13 DOI: 10.1016/j.jormas.2026.102716
Diogo de Vasconcelos Macedo, Milena Gomes Melo Leite, Maria Eduarda Carlos Conceição, Nicolau Conte Neto, Marcelo Silva Monnazzi

Objective: To evaluate, through three-dimensional finite element analysis (FEA), the stress and strain distribution in reconstruction plates of different thicknesses used for fixation of bone-grafted segmental mandibular defects.

Method: A dentate mandibular model was obtained from computed tomography data and digitally processed for FEA using ANSYS 7.0. Three reconstruction plate models (2.0, 2.4, and 3.0 mm thick) were applied to simulate defects in the symphyseal, body, and angle regions of the mandible, each associated with block bone grafts and fixed using 2.4-mm locking screws. A 300-N vertical occlusal load and muscle vectors representing masticatory forces were simulated. Stress distribution was analyzed according to von Mises criteria across plates, screws, and bone graft blocks.

Results: Increasing plate thickness reduced stress concentration within the plates but significantly increased stress on the fixation screws, particularly those adjacent to osteotomy lines. The symphyseal defect exhibited the highest stress values, followed by the body and angle defects. Stress values within bone graft blocks remained low (<250 MPa), indicating minimal deformation.

Conclusion: Thicker reconstruction plates enhance mechanical resistance but increase stress concentration on fixation screws, especially near osteotomies, suggesting a higher risk of screw loosening or peri-implant bone resorption. The anterior mandible demonstrated the most unfavorable stress distribution. Locking fixation systems are recommended when rigid plates are used to mitigate screw-related complications.

目的:通过三维有限元分析(FEA),评价不同厚度重建板固定骨移植下颌骨节段性缺损的应力应变分布。方法:利用计算机断层扫描数据建立齿状下颌骨模型,利用ANSYS 7.0软件进行有限元分析。三个重建板模型(2.0、2.4和3.0 mm厚)用于模拟下颌骨联合、体和角区缺陷,每个模型都与块骨移植物相关,并使用2.4 mm锁定螺钉进行固定。模拟300-N垂直咬合负荷和代表咀嚼力的肌肉矢量。根据von Mises标准分析钢板、螺钉和骨移植块之间的应力分布。结果:增加钢板厚度减少了钢板内的应力集中,但明显增加了固定螺钉上的应力,特别是截骨线附近的应力。联合缺损的应力值最高,其次为体缺损和角缺损。结论:较厚的重建钢板增加了机械阻力,但增加了固定螺钉的应力集中,特别是在截骨附近,提示螺钉松动或种植体周围骨吸收的风险较高。前下颌表现出最不利的应力分布。当使用刚性钢板以减轻螺钉相关并发症时,建议使用锁定固定系统。
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引用次数: 0
THE EMERGING ROLE OF ULTRASOUND IN FACIAL AESTHETIC PROCEDURES. 超声在面部美容过程中的新兴作用。
IF 2 3区 医学 Q2 Dentistry Pub Date : 2026-01-13 DOI: 10.1016/j.jormas.2026.102714
Davide Gerardi, Pierangelo Burdo, Gianluca Botticelli, Diana Torge, Francesca Angiolani, Fabiola Rinaldi, Giuseppe Varvara

Objective: Ultrasound imaging is gaining increasing relevance in facial aesthetic medicine due to its real-time, non-invasive, and radiation-free nature. The purpose of this scoping review was to explore the clinical applications of ultrasonography in aesthetic medicine.

Materials and methods: A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science to identify clinical studies evaluating the use of ultrasonography in facial aesthetic medicine. The search strategy included the following terms: "aesthetic", "facial", "ultrasound". PRISMA Extension for Scoping Review guidelines were used.

Results: A total of 6 studies were included in this review. Ultrasonography has been used to guide injections in facial aesthetic procedures such as filler and botulinum injection and to assess the thickness of the masseter muscle to evaluate the efficacy of masseter muscle hypertrophy treatment.

Conclusions: Ultrasonography enhances the safety of facial aesthetic procedures by guiding injections into the correct tissue layers and minimizing vascular risks. Priority should be given to the development of standardized protocols and an increase in randomized clinical trials.

目的:超声成像由于其实时、无创和无辐射的特性,在面部美容医学中越来越重要。本文旨在探讨超声检查在美容医学中的临床应用。材料和方法:通过PubMed、Scopus和Web of Science进行全面的文献检索,找出评估超声检查在面部美容医学中的应用的临床研究。搜索策略包括:“美学”、“面部”、“超声波”。使用了PRISMA扩展范围审查指南。结果:本综述共纳入6项研究。超声检查已被用于指导面部美容手术的注射,如填充剂和肉毒杆菌注射,并评估咬肌的厚度,以评估咬肌肥大治疗的疗效。结论:超声引导注射进入正确的组织层,降低血管风险,提高了面部美容手术的安全性。应优先考虑制定标准化方案和增加随机临床试验。
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引用次数: 0
AI-Assisted translation in Oral and Maxillofacial Surgery: A comparative evaluation. 人工智能辅助翻译在口腔颌面外科:比较评价。
IF 2 3区 医学 Q2 Dentistry Pub Date : 2026-01-13 DOI: 10.1016/j.jormas.2026.102717
Murillo Martins Pinto, Erick Elienai Reis Araújo, Zacharie Rahhal, Dani Stanbouly, Ricardo Grillo

Objectives: English dominates scientific communication, yet non-native speakers face significant barriers in publishing. Artificial intelligence (AI) translation tools offer a potential solution, but their efficacy requires systematic evaluation. The aim of this paper is to evaluate the performance of generative AI tools with a focus on their suitability for non-native English-speaking researchers.

Materials and methods: Thirty Non-English texts (150-300 words) across technical, academic, and descriptive genres were translated by six AI tools (ChatGPT-4.0, Claude 3.7, Copilot, Gemini 2.0, DeepSeek-V3, Perplexity) using standardized prompts. Translations were assessed via Grammarly® for correctness, clarity, engagement, and delivery. Statistical analysis (ANOVA, Kruskal-Wallis) compared performance.

Results: DeepSeek achieved the highest overall score (mean=92.9, p<0.001), significantly outperforming Claude (p=0.006) and Copilot (p=0.048), while matching Gemini (p=0.989). Gemini ranked second but frequently declined revisions, citing "already perfect" texts. Correctness varied significantly (p=0.0078), with Copilot excelling, while DeepSeek led in clarity, engagement, and delivery (p<0.01).

Conclusion: DeepSeek emerged as the most robust translator, with Gemini as a close second. AI translation can help reduce barriers but requires transparency and ongoing refinement to balance efficiency with academic rigor.

目的:英语在科学交流中占主导地位,但非英语母语者在出版方面面临重大障碍。人工智能(AI)翻译工具提供了一个潜在的解决方案,但它们的功效需要系统的评估。本文的目的是评估生成式人工智能工具的性能,重点关注它们对非英语母语研究人员的适用性。材料和方法:使用标准化提示,通过六个人工智能工具(ChatGPT-4.0、Claude 3.7、Copilot、Gemini 2.0、DeepSeek-V3、Perplexity)翻译30个非英语文本(150-300字),涵盖技术、学术和描述性类型。通过Grammarly®评估翻译的正确性、清晰度、参与性和交付性。统计分析(ANOVA, Kruskal-Wallis)比较性能。结果:DeepSeek获得了最高的总分(平均92.9分),结论:DeepSeek成为最强大的翻译器,Gemini紧随其后。人工智能翻译可以帮助减少障碍,但需要透明度和不断改进,以平衡效率和学术严谨性。
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引用次数: 0
Accuracy of static-guided pterygoid implant placement using mucosa-tooth-supported titanium templates: a retrospective cohort study. 使用粘膜牙支撑钛模板静态引导翼状体植入的准确性:一项回顾性队列研究。
IF 2 3区 医学 Q2 Dentistry Pub Date : 2026-01-12 DOI: 10.1016/j.jormas.2026.102715
Giovanni Battista Menchini-Fabris, Paolo Toti, Young Min Park, Andrea Bernardis, Saverio Cosola, Tommaso Grandi

Purposes: The aim of this retrospective cohort study was to evaluate the accuracy of pterygoid implant placement using static guides based on mucosa-tooth-supported titanium templates in fully edentulous patients. In addition, the study assessed whether deviations at the neck and apex tended to compensate or amplify along the implant axis by introducing the differential parameters.

Methods: Thirty-four patients (mean age 63.7 ± 9.0 years) received 62 pterygoid implants between September 2022 and July 2023. Virtual implant planning was performed on cone-beam computed tomography (CBCT)-derived datasets, and 3D printed resin surgical guides were fabricated to transfer the plan to the surgical field. Postoperative CBCT scans were superimposed onto the virtual plan using voxel-based registration, allowing vertical and horizontal measurement of deviations at the implant neck (v3, h3) and apex (v4, h4), as well as angular discrepancies (θ). Compensation and amplification effects were analyzed by computing vertical and horizontal differentials Δv and Δh. Data were expressed as medians and interquartile ranges (iqr).

Results: At the neck level, median vertical deviation was -0.54(0.59) mm and horizontal deviation 0.78(0.60) mm. At the apex, median vertical deviation was -0.41(0.61) mm, while horizontal deviation increased to 1.06(0.48) mm. The difference between h3 and h4 was significant (p < 0.0001), reflecting systematic amplification of horizontal misalignment. Angular deviation was low, with a median of 1.37(1.18) degrees. Analysis of Δv, about 0(0.31) mm, and Δh, +0.30(0.52) mm revealed that vertical errors were variably compensated apically, whereas horizontal errors tended to amplify. Quadrant analysis showed that while most implants displayed amplification, a subset exhibited partial or even double compensation when both vertical and horizontal deviations decreased apically.

Conclusion: Pterygoid implant placement with static guides based on mucosa-tooth-supported titanium templates demonstrated high accuracy, with deviations lower than those reported in meta-analyses and angular discrepancies markedly reduced. The introduction of Δv and Δh provided a novel insight into error propagation, highlighting compensatory versus amplifying trajectories.

目的:本回顾性队列研究的目的是评估在全无牙患者中使用基于粘膜-牙支撑钛模板的静态导向放置翼状种植体的准确性。此外,该研究通过引入微分参数来评估颈部和尖端的偏差是否倾向于沿种植体轴补偿或放大。方法:34例患者(平均年龄63.7±9.0岁)于2022年9月至2023年7月接受62例翼状骨植入。在锥束计算机断层扫描(CBCT)衍生的数据集上进行虚拟种植计划,并制作3D打印树脂手术指南以将计划传递到手术场。术后CBCT扫描使用基于体素的配准叠加到虚拟平面上,允许垂直和水平测量种植体颈部(v3, h3)和尖端(v4, h4)的偏差,以及角度差异(θ)。通过计算垂直和水平差Δv和Δh来分析补偿和放大效应。数据以中位数和四分位间距(iqr)表示。结果:颈部水平垂直偏差中位数为-0.54(0.59)mm,水平偏差中位数为0.78(0.60)mm,顶端垂直偏差中位数为-0.41(0.61)mm,水平偏差中位数增加至1.06(0.48)mm, h3与h4之间差异显著(p < 0.0001),反映了水平偏差的系统性放大。角度偏差较低,中位数为1.37(1.18)度。对Δv(约0(0.31)mm)和Δh (+0.30(0.52) mm)的分析表明,垂直误差在根尖上得到了不同程度的补偿,而水平误差则趋于放大。象限分析显示,虽然大多数种植体显示放大,但当垂直和水平偏差在根尖下降时,一小部分种植体表现出部分甚至双倍补偿。结论:基于粘膜牙支撑钛模板的静态导引翼状体种植体放置精度高,偏差低于meta分析报道,角度差异明显减少。Δv和Δh的引入提供了对错误传播的新见解,突出了补偿与放大轨迹。
{"title":"Accuracy of static-guided pterygoid implant placement using mucosa-tooth-supported titanium templates: a retrospective cohort study.","authors":"Giovanni Battista Menchini-Fabris, Paolo Toti, Young Min Park, Andrea Bernardis, Saverio Cosola, Tommaso Grandi","doi":"10.1016/j.jormas.2026.102715","DOIUrl":"https://doi.org/10.1016/j.jormas.2026.102715","url":null,"abstract":"<p><strong>Purposes: </strong>The aim of this retrospective cohort study was to evaluate the accuracy of pterygoid implant placement using static guides based on mucosa-tooth-supported titanium templates in fully edentulous patients. In addition, the study assessed whether deviations at the neck and apex tended to compensate or amplify along the implant axis by introducing the differential parameters.</p><p><strong>Methods: </strong>Thirty-four patients (mean age 63.7 ± 9.0 years) received 62 pterygoid implants between September 2022 and July 2023. Virtual implant planning was performed on cone-beam computed tomography (CBCT)-derived datasets, and 3D printed resin surgical guides were fabricated to transfer the plan to the surgical field. Postoperative CBCT scans were superimposed onto the virtual plan using voxel-based registration, allowing vertical and horizontal measurement of deviations at the implant neck (v<sup>3</sup>, h<sub>3</sub>) and apex (v<sub>4</sub>, h<sub>4</sub>), as well as angular discrepancies (θ). Compensation and amplification effects were analyzed by computing vertical and horizontal differentials Δv and Δh. Data were expressed as medians and interquartile ranges (iqr).</p><p><strong>Results: </strong>At the neck level, median vertical deviation was -0.54(0.59) mm and horizontal deviation 0.78(0.60) mm. At the apex, median vertical deviation was -0.41(0.61) mm, while horizontal deviation increased to 1.06(0.48) mm. The difference between h<sub>3</sub> and h<sub>4</sub> was significant (p < 0.0001), reflecting systematic amplification of horizontal misalignment. Angular deviation was low, with a median of 1.37(1.18) degrees. Analysis of Δv, about 0(0.31) mm, and Δh, +0.30(0.52) mm revealed that vertical errors were variably compensated apically, whereas horizontal errors tended to amplify. Quadrant analysis showed that while most implants displayed amplification, a subset exhibited partial or even double compensation when both vertical and horizontal deviations decreased apically.</p><p><strong>Conclusion: </strong>Pterygoid implant placement with static guides based on mucosa-tooth-supported titanium templates demonstrated high accuracy, with deviations lower than those reported in meta-analyses and angular discrepancies markedly reduced. The introduction of Δv and Δh provided a novel insight into error propagation, highlighting compensatory versus amplifying trajectories.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102715"},"PeriodicalIF":2.0,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Hidden Cost of the Perfect Case Report: Are We Publishing Only Successes? 完美案例报告的隐性成本:我们只发表成功案例吗?
IF 2 3区 医学 Q2 Dentistry Pub Date : 2026-01-08 DOI: 10.1016/j.jormas.2026.102713
Anuj Jain

Background: Case reports play a critical role in Oral and Maxillofacial Surgery (OMFS) by documenting rare presentations, unexpected complications, and complex intraoperative events. However, contemporary publication patterns suggest a bias toward reporting "ideal" outcomes, potentially limiting opportunities for complication-based learning.

Methods: A narrative review of bibliometric studies and large-scale clinical reports published between 2008 and 2025 was conducted using journal archives and database searches (PubMed, Scopus). The review synthesised trends in case report publication across major OMFS journals and compared these with real-world complication rates reported in high-volume clinical studies.

Results: Case report publications in OMFS journals have progressively declined over the past decade. In BJOMS, complication- or novelty-focused short communications decreased from 52% in 2008-2009 to 35% in 2010-2011. In contrast, large clinical cohorts document substantial adverse event rates, ranging from 3.6% in third molar surgery to 43.7% in orthognathic surgery. This discrepancy highlights a growing gap between clinical reality and published literature.

Conclusion: The underrepresentation of complication-focused case reports skews perceptions of OMFS practice and limits experiential learning. Transparent, structured reporting of complications can enhance patient safety, strengthen surgical education, and better align published evidence with real-world outcomes. Journals should adopt policies that encourage and normalize the publication of clinically meaningful adverse events.

背景:病例报告在口腔颌面外科(OMFS)中起着至关重要的作用,它记录了罕见的表现、意外的并发症和复杂的术中事件。然而,当代的出版模式表明对“理想”结果的报道存在偏见,这可能限制了基于并发症的学习的机会。方法:利用期刊档案和数据库检索(PubMed, Scopus)对2008年至2025年间发表的文献计量学研究和大规模临床报告进行叙述性回顾。该综述综合了主要OMFS期刊上病例报告发表的趋势,并将其与大量临床研究中报告的真实并发症发生率进行了比较。结果:在过去十年中,OMFS期刊上的病例报告出版物逐渐减少。在BJOMS中,以并发症或新奇为重点的短通信从2008-2009年的52%下降到2010-2011年的35%。相比之下,大型临床队列记录了大量不良事件发生率,从第三磨牙手术的3.6%到正颌手术的43.7%不等。这一差异凸显了临床现实与已发表文献之间越来越大的差距。结论:以并发症为中心的病例报告的代表性不足,扭曲了对OMFS实践的看法,限制了经验学习。透明、结构化的并发症报告可以提高患者安全,加强外科教育,并更好地将已发表的证据与实际结果结合起来。期刊应采取政策,鼓励和规范临床有意义的不良事件的发表。
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引用次数: 0
Prevalence and Risk Factors of Cleft lip and/or Palate in Ethiopia: A Systematic Review and Meta-Analysis. 埃塞俄比亚唇裂和/或腭裂的患病率和危险因素:系统回顾和荟萃分析。
IF 2 3区 医学 Q2 Dentistry Pub Date : 2026-01-07 DOI: 10.1016/j.jormas.2026.102712
Mandefrogn Mammo Lemma, Firehiwot Gezahegn Abebe, Estifanos Esubalew Lewogineh

Background: Cleft lip and/or palate (CL/P) is the most common congenital orofacial anomalies worldwide, with a multifactorial etiology involving both genetic and environmental factors. This study aimed to estimate the pooled prevalence of CL/P in Ethiopia and identify the associated risk factors.

Materials and methods: We systematically searched PubMed, Scopus, and Google Scholar for studies published between 1990 and 2023. We included observational studies (cross-sectional, cohort, case-control, descriptive, and prospective) that reported prevalence data for CL/P in Ethiopia. Data were extracted using a standardized Excel form, and statistical analyses were conducted using STATA version 18. The primary outcome was the pooled prevalence of CL/P. Heterogeneity was assessed using Cochrane's Q test and the I² statistic, and meta-analysis was performed using a random-effects model. The methodological quality of the studies was assessed using the STROBE checklist (version 2007).

Results: Across ten studies comprising 19,024,539 births, the pooled birth prevalence of CL/P in Ethiopia was 0.24 per 1,000 live births (95% CI: 0.12-0.36). Considerable heterogeneity was observed among studies (I² = 99.94%, τ² = 0.04, Q = 8546.85, p < 0.001), reflecting substantial variability in prevalence estimates.

Conclusion: Although the prevalence of CL/P in Ethiopia is lower than the global average, it represents a significant public health concern. This underscores the need for strengthen preventive measures, promoting early detection, and expanding access to timely and comprehensive treatment services are essential for reducing the burden of these congenital anomalies.

背景:唇腭裂(clp)是世界范围内最常见的先天性口腔面部异常,其病因包括遗传和环境因素。本研究旨在估计埃塞俄比亚CL/P的总患病率,并确定相关的危险因素。材料和方法:我们系统地检索PubMed、Scopus和谷歌Scholar,检索1990年至2023年间发表的研究。我们纳入了观察性研究(横断面、队列、病例对照、描述性和前瞻性),这些研究报告了埃塞俄比亚CL/P的患病率数据。采用标准化Excel表格提取数据,使用STATA version 18进行统计分析。主要终点是CL/P的总患病率。采用Cochrane’s Q检验和I²统计量评估异质性,采用随机效应模型进行meta分析。使用STROBE检查表(2007版)评估研究的方法学质量。结果:在包括19,024,539例分娩的10项研究中,埃塞俄比亚CL/P的总出生患病率为每1,000例活产0.24例(95% CI: 0.12-0.36)。研究中观察到相当大的异质性(I² = 99.94%,τ² = 0.04,Q = 8546.85,p < 0.001),反映了患病率估计值的实质性差异。结论:尽管埃塞俄比亚的CL/P患病率低于全球平均水平,但它代表了一个重大的公共卫生问题。这强调需要加强预防措施,促进早期发现和扩大获得及时和全面治疗服务的机会,这对于减轻这些先天性异常的负担至关重要。
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引用次数: 0
Total Lower Lip and Chin Replantation in a Child Following a Trampoline Accident: A Case Report of Rescue Surgery with Intensive Leech Therapy. 蹦床事故后儿童全下唇及下巴再植一例:强化水蛭治疗的抢救手术。
IF 2 3区 医学 Q2 Dentistry Pub Date : 2026-01-07 DOI: 10.1016/j.jormas.2026.102709
V Sounthakith, A Schweitzer-Chaput, A Picard, J Prebot, A Galland, C Neiva-Vaz, R H Khonsari

Lip amputations in children may require urgent microsurgical management. Here we report a salvage procedure with partial survival following lower lip and chin replantation after a trampoline accident. Total amputation was managed with inferior labial artery anastomosis; however, venous drainage was not reestablished, necessitating leech therapy. Despite arterial revisions, 75% of the lip and 25% of the chin were lost by post-operative day 14. Reconstruction with a combined right Karapandzic flap and left Camille Bernard flap was performed one month later, supplemented by mesotherapy and nanofat injections. The outcome was marked by residual microstomia. These injuries are rare in children, often caused by dog bites. Venous anastomosis is frequently unfeasible, with leech therapy critical for drainage. When replantation is partially successful, reconstruction may involve local flaps or free tissue transfers. Microsurgical expertise, access to leech therapy and close collaboration with intensivists are essential for optimizing outcomes.

儿童唇部截肢可能需要紧急显微外科治疗。在此,我们报告一个在蹦床事故后下唇和下巴再植后部分存活的抢救手术。全截肢采用唇下动脉吻合术;然而,静脉引流没有恢复,需要水蛭治疗。尽管动脉修复,术后第14天75%的嘴唇和25%的下巴都消失了。1个月后行右侧Karapandzic皮瓣和左侧Camille Bernard皮瓣联合重建,并辅以化疗和纳米脂肪注射。结果以残留的小口畸形为标志。这些伤害在儿童中很少见,通常是由狗咬伤引起的。静脉吻合通常不可行,水蛭疗法对引流至关重要。当再植部分成功时,重建可能涉及局部皮瓣或游离组织转移。显微外科专业知识、获得水蛭疗法以及与重症医师密切合作对于优化结果至关重要。
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引用次数: 0
Novel De Novo CLCN7 Mutation in Refractory Osteopetrosis-Related Osteomyelitis: A Case Report and Multidisciplinary Therapeutic Dilemmas. 难治性骨质疏松相关骨髓炎的新CLCN7突变:一例报告和多学科治疗困境。
IF 2 3区 医学 Q2 Dentistry Pub Date : 2025-12-18 DOI: 10.1016/j.jormas.2025.102686
Yi-Wen Zhang, Qi-Yao Jin, Ming Xu, Jian-Ping Xu, Yu-Cai Zhong, Chong Li, Ke Lu

Background: Osteopetrosis, characterized by impaired osteoclast function and increased bone density, poses significant clinical challenges when complications like mandibular osteomyelitis arise. This report elucidates the clinicoradiographic progression and management of such a case in ADO-II, driven by a novel de novo CLCN7 c.2227C>T (p.R743W) mutation.

Case presentation: A 57-year-old male presented with refractory mandibular osteomyelitis accompanied by facial swelling and trismus. Radiographs revealed mandibular osteolysis, "sandwich vertebrae," and "Erlenmeyer flask" deformities. He had anemia and thrombocytopenia. Sequencing analysis revealed a de novo CLCN7 c.2227C>T (p.R743W) mutation in the patient. Therapeutic measures involved partial splenic artery embolization, administration of intravenous cefuroxime and ornidazole combined with hyperbaric oxygen therapy and pleural drainage. The osteomyelitis persisted due to avascular necrosis in sclerotic bone, despite the adoption of multidisciplinary management.

Conclusions: This case highlights the aggressive phenotype associated with the CLCN7 c.2227C>T (p.R743W) mutation, the importance of early genetic testing and personalized therapeutic strategies.

背景:骨质疏松症以破骨细胞功能受损和骨密度增加为特征,当颌骨骨髓炎等并发症出现时,对临床提出了重大挑战。本报告阐述了由一种新的新发CLCN7 c.2227C>T (p.R743W)突变驱动的ADO-II病例的临床放射学进展和治疗。病例介绍:一名57岁男性,因难治性下颌骨骨髓炎并伴有面部肿胀和咬牙。x线片显示下颌骨骨溶解,“夹心椎体”和“Erlenmeyer烧瓶”畸形。他患有贫血和血小板减少症。测序分析显示患者中有一个新生的CLCN7 c.2227C>T (p.R743W)突变。治疗措施包括部分脾动脉栓塞、静脉注射头孢呋辛和奥硝唑联合高压氧治疗和胸腔引流。尽管采用了多学科治疗,但由于硬化骨的无血管坏死,骨髓炎仍然存在。结论:该病例强调了与CLCN7 c.2227C>T (p.R743W)突变相关的侵袭性表型,以及早期基因检测和个性化治疗策略的重要性。
{"title":"Novel De Novo CLCN7 Mutation in Refractory Osteopetrosis-Related Osteomyelitis: A Case Report and Multidisciplinary Therapeutic Dilemmas.","authors":"Yi-Wen Zhang, Qi-Yao Jin, Ming Xu, Jian-Ping Xu, Yu-Cai Zhong, Chong Li, Ke Lu","doi":"10.1016/j.jormas.2025.102686","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102686","url":null,"abstract":"<p><strong>Background: </strong>Osteopetrosis, characterized by impaired osteoclast function and increased bone density, poses significant clinical challenges when complications like mandibular osteomyelitis arise. This report elucidates the clinicoradiographic progression and management of such a case in ADO-II, driven by a novel de novo CLCN7 c.2227C>T (p.R743W) mutation.</p><p><strong>Case presentation: </strong>A 57-year-old male presented with refractory mandibular osteomyelitis accompanied by facial swelling and trismus. Radiographs revealed mandibular osteolysis, \"sandwich vertebrae,\" and \"Erlenmeyer flask\" deformities. He had anemia and thrombocytopenia. Sequencing analysis revealed a de novo CLCN7 c.2227C>T (p.R743W) mutation in the patient. Therapeutic measures involved partial splenic artery embolization, administration of intravenous cefuroxime and ornidazole combined with hyperbaric oxygen therapy and pleural drainage. The osteomyelitis persisted due to avascular necrosis in sclerotic bone, despite the adoption of multidisciplinary management.</p><p><strong>Conclusions: </strong>This case highlights the aggressive phenotype associated with the CLCN7 c.2227C>T (p.R743W) mutation, the importance of early genetic testing and personalized therapeutic strategies.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102686"},"PeriodicalIF":2.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence transforms the future of oncology care. 人工智能改变肿瘤治疗的未来。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-09-01 Epub Date: 2024-05-16 DOI: 10.1016/j.jormas.2024.101915
Archana Behera, Mukesh Kumar Dharmalingam Jothinathan
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引用次数: 0
期刊
Journal of Stomatology Oral and Maxillofacial Surgery
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