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Patient-specific probabilistic atlas combining modified distance regularized level set for automatic liver segmentation in CT 结合改进距离正则化水平集的患者特异性概率图谱用于CT肝脏自动分割
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-10 DOI: 10.1080/24699322.2019.1649076
Jinke Wang, Hongliang Zu, Haoyan Guo, R. Bi, Yuanzhi Cheng, S. Tamura
Abstract Liver segmentation from CT is regarded as a prerequisite for computer-assisted clinical applications. However, automatic liver segmentation technology still faces challenges due to the variable shapes and low contrast. In this paper, a patient-specific probabilistic atlas (PA)-based method combing modified distance regularized level set for liver segmentation is proposed. Firstly, the similarities between training atlases and testing patient image are calculated, resulting in a series of weighted atlas, which are used to generate the patient-specific PA. Then, a most likely liver region (MLLR) can be determined based on the patient-specific PA. Finally, the refinement is performed by the modified distance regularized level set model, which takes advantage of both edge and region information as balloon force. We evaluated our proposed scheme based on 35 public datasets, and experimental result shows that the proposed method can be deployed for robust and precise liver segmentation, to replace the tedious and time-consuming manual method.
摘要CT肝脏分割是计算机辅助临床应用的前提。然而,由于形状多变和对比度低,自动肝脏分割技术仍然面临挑战。本文提出了一种结合改进的距离正则化水平集的基于患者特异性概率图谱(PA)的肝脏分割方法。首先,计算训练图谱和测试患者图像之间的相似性,得到一系列加权图谱,用于生成患者特异性PA。然后,可以基于患者特异性PA确定最可能的肝脏区域(MLLR)。最后,通过修改的距离正则化水平集模型进行细化,其利用边缘和区域信息作为气球力。我们基于35个公共数据集对我们提出的方案进行了评估,实验结果表明,该方法可以用于鲁棒和精确的肝脏分割,以取代繁琐和耗时的手动方法。
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引用次数: 5
Analysis of the time-velocity curve in phase-contrast magnetic resonance imaging: a phantom study 相位对比磁共振成像中时间-速度曲线的分析:体模研究
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-06 DOI: 10.1080/24699322.2019.1649066
Jieun Park, Junghun Kim, Yongmin Chang, S. Youn, Hui-Joong Lee, E. Kang, Ki-Nam Lee, V. Suchánek, S. Hyun, Jongmin Lee
Abstract The aim of this study was to analyze the characteristics of time-velocity curve acquired by phase-contrast magnetic resonance imaging (PC-MRI) using an in-vitro flow model as a reference for hemodynamic studies. The time- velocity curves of the PC-MRI were compared with Doppler ultrasonography (US) and also compared with those obtained in the electromagnetic flowmeter. The correlation between techniques was analyzed using an electromagnetic flowmeter as a reference standard; the maximum, minimum, and average velocities, full-width at half-maximum (FWHM), and ascending gradient (AG) were measured from time-velocity curves. The correlations between an electromagnetic flowmeter and the respective measurement technique for the PC-MRI and Doppler US were found to be high (mean R2 > 0.9, p < 0.05). These results indicate that these measurement techniques are useful for measuring blood flow information and reflect actual flow. The PC-MRI was the best fit for the minimum velocity and FWHM, and the maximum velocity and AG were the best fit for Doppler US. The PC-MRI showed lower maximum velocity value and higher minimum velocity value than Doppler US. Therefore, PC-MRI demonstrates more obtuse time-velocity curve than Doppler US. In addition, the time- velocity curve of PC-MRI could be calibrated by introducing formulae that can convert each measurement value to a reference standard value within a 10% error. The PC-MRI can be used to estimate the Doppler US using this formula.
摘要本研究的目的是分析相对比磁共振成像(PC-MRI)获得的时间-速度曲线特征,以体外血流模型为血液动力学研究的参考。将PC-MRI的时间-速度曲线与多普勒超声(US)以及电磁流量计的时间-速度曲线进行了比较。以电磁流量计为参考标准,分析了各技术间的相关性;时间-速度曲线测量了最大、最小和平均速度,半最大全宽度(FWHM)和上升梯度(AG)。发现电磁流量计与PC-MRI和多普勒US各自测量技术之间的相关性很高(平均R2 > 0.9, p < 0.05)。这些结果表明,这些测量技术是有用的测量血流信息和反映实际流量。PC-MRI最适合最小速度和FWHM,最大速度和AG最适合多普勒US。PC-MRI显示最大速度值低于多普勒超声,最小速度值高于多普勒超声。因此,PC-MRI表现出比多普勒US更钝的时间-速度曲线。此外,PC-MRI的时速度曲线可以通过引入公式进行校准,该公式可以在10%的误差范围内将每个测量值转换为参考标准值。PC-MRI可用此公式估计多普勒超声。
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引用次数: 3
A visible human body slice segmentation method framework based on OneCut and adjacent image geometric features 基于oneccut和相邻图像几何特征的可见人体切片分割方法框架
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-06 DOI: 10.1080/24699322.2019.1649068
B. Liu, Simei Li, Jingyi Zhang, Qian Wu, Liang Yang, Wen Qi, Sijie Guan, Shuo Zhang, Jianxin Zhang
Abstract As a recent research hot issue, obtaining the accurate 3 D organ models of Visible Human Project (VHP) has many significances. Therefore, how to extract the organ regions of interest (ROI) in the large-scale color slice image data set has become an urgent issue to be solved. In this paper, we propose a method framework based on OneCut algorithm and adjacent image geometric features to continuously extract the main organ regions is proposed. This framework mainly contains two parts: firstly, the OneCut algorithm is used to segment the ROI of target organ in the current image; secondly, the foreground image (obtained ROI) is corroded into several seed points and the background image (other region except for ROI) is refined into a skeleton. Then the obtained seed points and skeleton can be transmitted and mapped onto the next image as the input of OneCut algorithm. Thereby, the serialized slice images can be processed continuously without manual delineating. The experimental results show that the extracted VHP organs are satisfactory. This method framework may provide well technic foundation for other related application.
摘要作为近年来研究的热点问题,获得准确的3 可见人体计划(VHP)的D器官模型具有许多意义。因此,如何在大规模彩色切片图像数据集中提取感兴趣器官区域(ROI)成为亟待解决的问题。本文提出了一种基于OneCut算法和相邻图像几何特征的连续提取主要器官区域的方法框架。该框架主要包括两个部分:首先,OneCut算法用于分割当前图像中目标器官的ROI;其次,将前景图像(获得的ROI)腐蚀成几个种子点,将背景图像(除ROI外的其他区域)细化成骨架。然后,可以将获得的种子点和骨架传输并映射到下一个图像上,作为OneCut算法的输入。从而,可以在没有手动描绘的情况下连续处理序列化的切片图像。实验结果表明,提取的VHP器官是令人满意的。该方法框架可为其他相关应用提供良好的技术基础。
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引用次数: 1
Advances in computer-aided medical systems and clinical measurement 计算机辅助医疗系统与临床测量的进展
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-02 DOI: 10.1080/24699322.2019.1649079
Chengyu Liu, L. Pan
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引用次数: 0
Modeling of soft tissue thermal damage based on GPU acceleration 基于GPU加速的软组织热损伤建模
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-07-24 DOI: 10.1080/24699322.2018.1557891
Jinao Zhang, J. Hills, Y. Zhong, B. Shirinzadeh, Julian Smith, Chengfan Gu
Abstract Hyperthermia treatments require precise control of thermal energy to form the coagulation zones which sufficiently cover the tumor without affecting surrounding healthy tissues. This has led modeling of soft tissue thermal damage to become important in hyperthermia treatments to completely eradicate tumors without inducing tissue damage to surrounding healthy tissues. This paper presents a methodology based on GPU acceleration for modeling and analysis of bio-heat conduction and associated thermal-induced tissue damage for prediction of soft tissue damage in thermal ablation, which is a typical hyperthermia therapy. The proposed methodology combines the Arrhenius Burn integration with Pennes’ bio-heat transfer for prediction of temperature field and thermal damage in soft tissues. The problem domain is spatially discretized on 3-D linear tetrahedral meshes by the Galerkin finite element method and temporally discretized by the explicit forward finite difference method. To address the expensive computation load involved in the finite element method, GPU acceleration is implemented using the High-Level Shader Language and achieved via a sequential execution of compute shaders in the GPU rendering pipeline. Simulations on a cube-shape specimen and comparison analysis with standalone CPU execution were conducted, demonstrating the proposed GPU-accelerated finite element method can effectively predict the temperature distribution and associated thermal damage in real time. Results show that the peak temperature is achieved at the heat source point and the variation of temperature is mainly dominated in its direct neighbourhood. It is also found that by the continuous application of point-source heat energy, the tissue at the heat source point is quickly necrotized in a matter of seconds, while the entire neighbouring tissues are fully necrotized in several minutes. Further, the proposed GPU acceleration significantly improves the computational performance for soft tissue thermal damage prediction, leading to a maximum reduction of 55.3 times in computation time comparing to standalone CPU execution.
热疗治疗需要精确控制热能,形成足以覆盖肿瘤而不影响周围健康组织的凝血区。这使得软组织热损伤的建模在热疗治疗中变得重要,以完全根除肿瘤而不引起周围健康组织的组织损伤。本文提出了一种基于GPU加速的生物热传导及相关热致组织损伤建模与分析方法,用于热消融中软组织损伤的预测,这是一种典型的热疗治疗。该方法将Arrhenius Burn理论与Pennes的生物传热理论相结合,用于预测软组织的温度场和热损伤。用伽辽金有限元法在三维线性四面体网格上进行空间离散,用显式正演有限差分法在时间上进行离散。为了解决有限元方法中涉及的昂贵的计算负载,GPU加速使用高级着色器语言实现,并通过GPU渲染管道中计算着色器的顺序执行来实现。通过对一个立方体试件的仿真和与独立CPU运行的对比分析,验证了所提出的gpu加速有限元方法可以有效地实时预测温度分布和相关的热损伤。结果表明,温度峰值出现在热源点,温度变化主要集中在热源附近。还发现,通过持续施加点源热能,热源处的组织在几秒钟内迅速坏死,而整个邻近组织在几分钟内完全坏死。此外,所提出的GPU加速显著提高了软组织热损伤预测的计算性能,与独立CPU执行相比,计算时间最多减少了55.3倍。
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引用次数: 5
Super resolution reconstruction for medical image based on adaptive multi-dictionary learning and structural self-similarity. 基于自适应多字典学习和结构自相似的医学图像超分辨率重建。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-03-01 DOI: 10.1080/24699322.2018.1557906
Fang Zhang,Yue Wu,Zhitao Xiao,Lei Geng,Jun Wu,Jia Wen,Wen Wang,Ping Liu
To improve the quality of the super-resolution (SR) reconstructed medical images, an improved adaptive multi-dictionary learning method is proposed, which uses the combined information of medical image itself and the natural images database. In training dictionary section, it uses the upper layer images of pyramid which are generated by the self-similarity of low resolution images. In reconstruction section, the top layer image of pyramid is taken as the initial reconstruction image, and medical image's SR reconstruction is achieved by regularization term which is the non-local structure self-similarity of the image. This method can make full use of the same scale and different scale similar information of medical images. Simulation experiments are carried out on natural images and medical images, and the experimental results show the proposed method is effective for improving the effect of medical image SR reconstruction.
为了提高重建的超分辨率医学图像的质量,提出了一种改进的自适应多字典学习方法,该方法将医学图像本身的信息与自然图像数据库相结合。在训练字典部分,使用低分辨率图像的自相似度生成的金字塔上层图像。在重建部分,以金字塔的顶层图像作为初始重建图像,通过正则化项即图像的非局部结构自相似性来实现医学图像的SR重建。该方法可以充分利用医学图像的相同尺度和不同尺度的相似信息。对自然图像和医学图像进行了仿真实验,实验结果表明,该方法能够有效提高医学图像SR重建的效果。
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引用次数: 0
A targeting method for robot-assisted percutaneous needle placement under fluoroscopy guidance. 透视引导下机器人辅助经皮置针的靶向方法。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-02-02 DOI: 10.1080/24699322.2018.1560085
Zhonghao Han,Keyi Yu,Lei Hu,Weishi Li,Huilin Yang,Minfeng Gan,Na Guo,Biao Yang,Hongsheng Liu,Yuhan Wang
BACKGROUNDMinimally invasive procedures are rapidly growing in popularity thanks to advancements in medical robots, visual navigation and space registration techniques. This paper presents a precise and efficient targeting method for robot-assisted percutaneous needle placement under C-arm fluoroscopy.METHODA special end-effector was constructed to perform fluoroscopy calibration and robot to image-space registration simultaneously and automatically. In addition, formulations were given to compute the movement of robot targeting and evaluate targeting accuracy using only one X-ray image.RESULTA pre-clinical experiment showed that the maximum angle error was 0.94° and the maximum position error of a target located 80 mm below the end-effector was 1.31 mm. And evaluation of the system in a robot-assisted pedicle screws placement surgery has justified the accuracy and reliability of proposed method in clinical applications.CONCLUSIONThe positioning accuracy was increased by using present method. Moreover, radiation exposure and operation time were reduced significantly compared to other commonly used methods.
背景:由于医疗机器人、视觉导航和空间注册技术的进步,微创手术正在迅速普及。本文介绍了一种在c臂透视下机器人辅助下经皮置针的精确、高效的靶向方法。方法构建专用末端执行器,同时自动完成透视定标和机器人图像空间配准。此外,给出了单x射线图像下机器人瞄准运动计算和瞄准精度评估的公式。结果临床前实验表明,最大角度误差为0.94°,位于末端执行器下方80 mm处的目标最大位置误差为1.31 mm。该系统在机器人辅助椎弓根螺钉置入手术中的应用验证了该方法在临床应用中的准确性和可靠性。结论采用本方法可提高定位精度。此外,与其他常用方法相比,辐射暴露和手术时间明显减少。
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引用次数: 0
The role of the precuneus and posterior cingulate cortex in the neural routes to action. 楔前叶和后扣带皮层在神经通路中的作用。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-01-28 DOI: 10.1080/24699322.2018.1560098
Zijian Wang,Fei Liu,Yaoru Sun,Jie Li,Fang Wang,Zheng Lu
Neural substrates of action to the object or this specific direct route, however, remain unclear, especially for the connection from the visual pathway to the motor cortex. The study examined this issue by conducting an fMRI experiment, in which two action generation tasks involving pictures of real objects (PA) and the object's nouns (NA) were used, with pictures naming (PN) and covert noun reading (NR) being the control tasks. The result showed that the model predefined for the PCC and precuneus connecting IPL to the posterior-medial frontal cortex dominated over the others (with 0.45 probability), suggesting that the PCC and the precuneus locate at the neural substrates of action to the object. Furthermore, a feasibility study suggests that the neural pathway composed of the V3/MT, precuneus, PCC, and PM (premotor cortex) forms the direct route from perception to action, which also links to the dorsal pathway so that the perception of objects bypasses the semantic ventral pathway and then directly cues actions via the affordance.
然而,对物体或这一特定直接通路的作用的神经基质,特别是从视觉通路到运动皮层的连接,仍不清楚。该研究通过功能磁共振成像(fMRI)实验检验了这一问题,实验中使用了两个动作生成任务,涉及真实物体的图片(PA)和物体的名词(NA),其中图片命名(PN)和隐蔽名词阅读(NR)是控制任务。结果表明,PCC和楔前叶连接IPL与后内侧额叶皮层的模型优于其他模型(概率为0.45),表明PCC和楔前叶位于对物体产生作用的神经底物上。此外,一项可行性研究表明,由V3/MT、楔前叶、PCC和PM(运动前皮质)组成的神经通路形成了从感知到行动的直接途径,并与背侧通路相连,从而使物体的感知绕过语义腹侧通路,直接通过功能提示提示动作。
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引用次数: 0
Analysis and recognition of characteristics of digitized tongue pictures and tongue coating texture based on fractal theory in traditional Chinese medicine. 基于中医分形理论的数字化舌图及舌苔纹理特征分析与识别。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-01-24 DOI: 10.1080/24699322.2018.1557890
Ji Zhang,Jun Qian,Tao Yang,Hai-Yan Dong,Rui-Juan Wang
Simple fractal dimensions have been proposed for use in the analysis of the characteristics of digitized tongue pictures and tongue coating texture, which could further the establishment of objectified classification criteria under the conditions of expanding sample size. However, detailed descriptions on simple fractal dimensions have been limited. Therefore, BP (back propagation) neural network model classifiers could be designed by further calculation of the multiple fractal spectrum characteristics of digitized tongue pictures in order to classify and recognize the thin/thick or greasy characteristics of tongue coating.The fractal dimensions of sample data of 587 digitized tongue pictures were collected in a standard environment. A statistical analysis was conducted on the calculation results of the sample data, and the sensitivity of the fractal dimensions to the thin/thick and greasy characteristics of digitized tongue pictures was observed. As the overlap region resulted from a range of values of a single parameter, another eight characteristic parameters of the multiple fractal spectra of the digitized tongue pictures were further proposed as the elements in the input layer of the three-layers BP neural network. Automatic recognition classifiers were designed and trained for the characteristics of digitized tongue pictures and tongue coating textures.The simple fractal dimension was sensitive to the thin/thick and greasy characteristics of digitized tongue pictures and could better judge the characteristics of the thickness of the tongue coating. A classifier with characteristic parameters of multiple fractal spectra as the input vectors identified by the BP neural network models could effectively increase the accuracy rate judged by the characteristics of the tongue coating texture.
提出了简单分形维数用于分析数字化舌图特征和舌苔纹理,可在扩大样本量的条件下进一步建立客观的分类标准。然而,对简单分形维数的详细描述是有限的。因此,通过进一步计算数字化舌头图像的多重分形谱特征,可以设计BP (back propagation)神经网络模型分类器,对舌苔的薄/厚或油腻特征进行分类识别。在标准环境下采集了587张数字化舌图样本数据的分形维数。对样本数据的计算结果进行统计分析,观察分形维数对数字化舌图薄/厚、油腻特征的敏感性。由于重叠区域是由单个参数的取值范围造成的,因此进一步提出了数字化舌图多重分形谱的另外8个特征参数作为三层BP神经网络输入层的元素。针对数字化舌图和舌苔纹理特征,设计并训练了自动识别分类器。简单分形维数对数字化舌苔图像的薄/厚、油腻特征较为敏感,能较好地判断舌苔厚度特征。以多重分形谱特征参数作为BP神经网络模型识别的输入向量,可以有效提高舌膜纹理特征判断的准确率。
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引用次数: 0
Physiological interference reduction for near infrared spectroscopy brain activity measurement based on recursive least squares adaptive filtering and least squares support vector machines. 基于递推最小二乘自适应滤波和最小二乘支持向量机的近红外光谱脑活动测量生理干扰抑制。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-01-01 DOI: 10.1080/24699322.2018.1560095
Xin Liu, Yan Zhang, Dan Liu, Qisong Wang, Ou Bai, Jinwei Sun, P. Rolfe
Near infrared spectroscopy is the promising and noninvasive technique that can be used to detect the brain functional activation by monitoring the concentration alternations in the haemodynamic concentration. The acquired NIRS signals are commonly contaminated by physiological interference caused by breathing and cardiac contraction. Though the adaptive filtering method with least mean squares algorithm or recursive least squares algorithm based on multidistance probe configuration could improve the quality of evoked brain activity response, both methods can only remove the physiological interference occurred in superficial layers of the head tissue. To overcome the shortcoming, we combined the recursive least squares adaptive filtering method with the least squares support vector machine to suppress physiological interference both in the superficial layers and deeper layers of the head tissue. The quantified results based on performance measures suggest that the estimation performances of the proposed method for the evoked haemodynamic changes are better than the traditional recursive least squares method.
近红外光谱技术是一种很有前途的无创技术,它可以通过监测血流动力学浓度的变化来检测脑功能的激活。获得的近红外光谱信号通常受到呼吸和心脏收缩引起的生理干扰的污染。采用最小均方算法的自适应滤波方法或基于多距离探头配置的递推最小二乘算法虽然可以提高脑活动诱发反应的质量,但这两种方法都只能去除头部组织浅层的生理干扰。为了克服这一缺点,我们将递归最小二乘自适应滤波方法与最小二乘支持向量机相结合,对头部组织的表层和深层进行生理干扰抑制。基于性能测量的量化结果表明,该方法对诱发血流动力学变化的估计性能优于传统的递推最小二乘法。
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引用次数: 0
期刊
Computer Assisted Surgery
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