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Quantitative assessment of three vendor’s metal artifact reduction techniques for CT imaging using a customized phantom 定量评估三个供应商的金属伪影减少技术用于CT成像使用定制的幻影
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-09-10 DOI: 10.1080/24699322.2019.1649075
R. Chou, Jung-Hui Li, Liu-Kuo Ying, Cheng-Hsun Lin, Wan Leung
Abstract A metal implant was placed in an acrylic phantom to enable quantitative analysis of the metal artifact reduction techniques used in computed tomography (CT) scanners from three manufacturers. Two titanium rods were placed in a groove in a cylindrical phantom made by acrylic, after which the groove was filled with water. The phantom was scanned using three CT scanners (Toshiba, GE, Siemens) under the abdomen CT setting. CT number accuracy, contrast-to-noise ratio, area of the metal rods in the images, and fraction of affected pixel area of water were measured using ImageJ. Different iterative reconstruction, dual energy, and metal artifact reduction techniques were compared within three vendors. The highest contrast-to-noise ratio of three scanners were 85.7 ± 8.4 (Toshiba), 85.9 ± 11.7 (GE), and 55.0 ± 14.8 (Siemens); and the most correct results of metal area were 157.1 ± 1.4 mm2 (Toshiba), 155.0 ± 1.0 (GE), and 170.6 ± 5.3 (Siemens). The fraction of affected pixel area obtained using single-energy metal artifact reduction of Toshiba scanner was 2.2% ± 0.7%, which is more favorable than 4.1% ± 0.7% obtained using metal artifact reduction software of GE scanner (p = 0.002). Among all quantitative results, the estimations with fraction of affected pixel areas matched the effect of metal artifact reduction in the actual images. Therefore, the single-energy metal artifact reduction technique of Toshiba scanner had a desirable effect. The metal artifact reduction software of GE scanner effectively reduced the effect of metal artifacts; however, it underestimated the size of the metal rods. The monoenergetic and dual energy composition techniques of Siemens scanner could not effectively reduce metal artifacts.
将金属植入物放置在丙烯酸体中,以便对来自三家制造商的计算机断层扫描(CT)扫描仪中使用的金属伪影减少技术进行定量分析。将两根钛棒放在一个由丙烯酸制成的圆柱形幻影的凹槽中,然后将凹槽填满水。在腹部CT设置下使用三台CT扫描仪(东芝、GE、西门子)扫描幻体。利用ImageJ测量CT数精度、图像中金属棒的面积、水的影响像元面积的比例。不同的迭代重建、双能量和金属伪影减少技术在三个供应商之间进行了比较。三种扫描仪的最高噪比分别为东芝(Toshiba) 85.7±8.4、GE (GE) 85.9±11.7、西门子(Siemens) 55.0±14.8;最正确的金属面积分别为东芝(Toshiba) 157.1±1.4 mm2、GE (GE) 155.0±1.0 mm2、Siemens (Siemens) 170.6±5.3 mm2。东芝扫描仪单能量金属伪影还原获得的影响像元面积占比为2.2%±0.7%,优于GE扫描仪金属伪影还原软件获得的4.1%±0.7% (p = 0.002)。在所有的定量结果中,受影响像素面积比例的估计与实际图像中金属伪影的减少效果相匹配。因此,东芝扫描仪的单能金属伪影还原技术具有理想的效果。GE扫描仪的金属伪影降低软件有效降低了金属伪影的影响;然而,它低估了金属棒的大小。西门子扫描仪的单能和双能组成技术不能有效地减少金属伪影。
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引用次数: 5
Evaluation of laparoscopic forceps jaw contact pressure and distribution using pressure sensitive film 用压敏膜评价腹腔镜钳颌接触压力及分布
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-29 DOI: 10.1080/24699322.2019.1649073
Rui Zhu, M. Maréchal, I. Yamamoto, M. Lawn, T. Nagayasu, Keitaro Matsumoto
Abstract In this study, the authors used the Fujifilm Prescale Pressure Measuring System to measure the contact pressure and distribution at the jaws of laparoscopic grasping forceps. This data was then correlated with measured pressures at the forceps handles to understand the relationship between the surgeon’s actuating pressure and that on the organ being manipulated. The purpose of this study is to create a database of tactile information to provide guidelines in defining minimally invasive surgery (MIS). This is expected to be important as today's society continues to progress in the use of automation, IoT, AI and MIS. In order to achieve the above, the authors developed an experimental device consisting of an actuator, a load cell and an MCU to stably actuate and control the handle side of grasping forceps. Target organs were simulated using triangular prisms of various silicone rubber materials. The experimental method involved actuating the handle side with preset pressure values for fixed time periods and using sensitive film to measure the pressure at the forceps tip. The film data was then scanned, processed and analyzed.
在本研究中,作者使用富士胶片预刻度压力测量系统测量腹腔镜钳钳钳口处的接触压力和分布。然后将这些数据与钳柄处测量的压力相关联,以了解外科医生的驱动压力与被操作器官的压力之间的关系。本研究的目的是建立触觉信息数据库,为微创手术(MIS)的定义提供指导。随着当今社会在自动化、物联网、人工智能和管理信息系统的使用方面不断进步,这一点预计将非常重要。为了实现上述目标,作者开发了一种由执行器、称重传感器和单片机组成的实验装置,以稳定地驱动和控制抓取钳的手柄侧。用不同硅橡胶材料的三角棱镜模拟靶器官。实验方法是在固定的时间段内以预设的压力值驱动手柄侧,并使用敏感薄膜测量钳尖处的压力。然后对胶片数据进行扫描、处理和分析。
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引用次数: 4
Design and control of a MRI-compatible pneumatic needle puncture robot 磁共振兼容气动穿刺机器人的设计与控制
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-26 DOI: 10.1080/24699322.2019.1649067
Baoliang Zhao, Y. Fu, Yuanyuan Yang, Peng Zhang, Ying Hu
Abstract Percutaneous needle puncture operation is widely used in the image-guided interventions, including biopsy and ablation. MRI guidance has the advantages of high-resolution soft tissue imaging and thermal monitoring during energy-based ablation. This paper proposes the design of a 5-DOF pneumatic needle puncture robot, with all the cylinders, sensors and structure material MRI-compatible. Also, a hybrid fuzzy-PID controller is designed for the pneumatic driven system to adjust the PID parameters adaptively. The experiment validation result shows that, compared with the traditional fix-parameter PID control, the proposed hybrid fuzzy-PID control has no overshoot, and the settle time/steady state error remains low even with increasing load. This proves that the hybrid fuzzy-PID control strategy can increases the positioning accuracy and robustness of the pneumatic driven needle puncture robot, which is significant for the safety of percutaneous needle puncture operation.
摘要经皮穿刺术广泛应用于图像引导下的介入治疗,包括活检和消融。MRI引导在基于能量的消融过程中具有高分辨率软组织成像和热监测的优势。本文提出了一种五自由度气动穿刺机器人的设计,该机器人的所有气缸、传感器和结构材料MRI都兼容。针对气动驱动系统,设计了一种混合模糊PID控制器,对PID参数进行自适应调节。实验验证结果表明,与传统的定参数PID控制相比,所提出的混合模糊PID控制没有超调,即使在负载增加的情况下,稳定时间/稳态误差也很低。这证明了混合模糊PID控制策略可以提高气动穿刺机器人的定位精度和鲁棒性,对经皮穿刺操作的安全性具有重要意义。
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引用次数: 5
Encoder-decoder with dense dilated spatial pyramid pooling for prostate MR images segmentation 用于前列腺MR图像分割的密集扩张空间金字塔池编码器-解码器
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-19 DOI: 10.1080/24699322.2019.1649069
Lei Geng, Jia Wang, Zhitao Xiao, Jun Tong, Fang Zhang, Jun Wu
Abstract Automatic segmentation of prostate magnetic resonance (MR) images has great significance for the diagnosis and clinical application of prostate diseases. It faces enormous challenges because of the low contrast of the tissue boundary and the small effective area of the prostate MR images. In order to solve these problems, we propose a novel end-to-end professional network which consists of an Encoder-Decoder structure with dense dilated spatial pyramid pooling (DDSPP) for prostate segmentation based on deep learning. First, the DDSPP module is used to extract the multi-scale convolution features in the prostate MR images, and then the decoder is used to capture the clear boundary of prostate. Competitive results are produced over state of the art on 130 MR images which key metrics Dice similarity coefficient (DSC) and Hausdorff distance (HD) are 0.954 and 1.752 mm respectively. Experimental results show that our method has high accuracy and robustness.
前列腺磁共振图像的自动分割对前列腺疾病的诊断和临床应用具有重要意义。由于组织边界的低对比度和前列腺MR图像的小有效面积,它面临着巨大的挑战。为了解决这些问题,我们提出了一种新的端到端专业网络,该网络由具有密集扩张空间金字塔池(DDSPP)的编码器-解码器结构组成,用于基于深度学习的前列腺分割。首先,使用DDSPP模块提取前列腺MR图像中的多尺度卷积特征,然后使用解码器捕获前列腺的清晰边界。在130张MR图像上产生了与现有技术相比具有竞争力的结果,这些图像的关键度量Dice相似性系数(DSC)和Hausdorff距离(HD)分别为0.954和1.752 mm。实验结果表明,该方法具有较高的精度和鲁棒性。
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引用次数: 10
Development of modified RSA algorithm using fixed mersenne prime numbers for medical ultrasound imaging instrumentation 医学超声成像仪器中使用固定梅森素数的改进RSA算法的发展
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-14 DOI: 10.1080/24699322.2019.1649070
Seung-Hyeok Shin, Won-Sok Yoo, Hojong Choi
Abstract Purpose: Encryption of patient information has become an important issue in medical ultrasound instrumentation to secure information when images are accessed off-site. The proposed algorithm is used to encrypt private medical images and transfer the encrypted images to improve the encryption capability and elapsed time. Materials and methods: We generate a public key using three prime numbers, including a fixed Mersenne prime number, in the modified Rivest-Shamir-Adelman (RSA) algorithm to compare the encryption capability. We calculated and compared the elapsed time using the modified RSA algorithm with a breast phantom in the medical ultrasound imaging instrumentation. Results: The encryption capability is improved because the elapsed time when using three prime numbers is longer (1.2337 s) than that when using two prime numbers (1.0712 s). However, the elapsed time using fixed Mersenne prime numbers (0.8360 s) is a similar to that using two prime numbers (0.8389 s). Conclusions: Our proposed cryptographic algorithm provides improved encryption in medical ultrasound imaging compared to algorithms that use two prime numbers that are not Mersenne prime numbers, while transmitting images with adequate elapsed times.
摘要目的:患者信息的加密已成为医疗超声仪器中的一个重要问题,以确保在非现场访问图像时信息的安全。该算法用于对私人医学图像进行加密并传输加密后的图像,以提高加密能力和经过的时间。材料和方法:在改进的Rivest-Shamir Adelman(RSA)算法中,我们使用三个素数生成公钥,其中包括一个固定的Mersenne素数,以比较加密能力。我们使用改进的RSA算法和医学超声成像仪器中的乳房模型计算并比较了经过的时间。结果:由于使用三个素数所用的时间更长(1.2337 s) 比使用两个素数(1.0712 s) 。然而,使用固定梅森素数(0.8360 s) 类似于使用两个素数(0.8389 s) 。结论:与使用两个不是梅森素数的素数的算法相比,我们提出的加密算法在医学超声成像中提供了改进的加密,同时传输图像具有足够的经过时间。
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引用次数: 8
Assisted therapeutic system based on reinforcement learning for children with autism 基于强化学习的自闭症儿童辅助治疗系统
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-14 DOI: 10.1080/24699322.2019.1649072
Minjia Li, Xue Li, Lun Xie, Jing Liu, Feifei Wang, Zhiliang Wang
Abstract Assisted therapy is increasingly used in autism spectrum disorders (ASD) for improving social interaction and communication skills in recent years. A lot of studies have proven that the form of interactive games for therapy has a good effect on children with autism. Thus, our study provided an assisted therapeutic system based on Reinforcement Learning (RL) for children with ASD, which has five interactive subgames. As is well known, it is necessary to establish and maintain compelling interactions in therapeutic process. Therefore, we aim to adjust the interactive content according to the emotions of children with autism. However, due to the atypical and unusually differences in children with autism, most systems are based on off-line training of small samples of individuals and online recognition, so the existing assisted systems are limited in their ability to automatically update system parameters of new mappings. The integration of RL and Convolutional Neural Network (CNN)-Support Vector Regression (SVR) was used to deal with the updating online of prediction model’s weights. The normalized emotion labels were evaluated by the therapists. Eleven children with autism as subjects were invited in this experiment and captured facial video images. The experiment lasted for five weeks of intermittent assisted therapy, and the results were evaluated for the system and the therapy effect. Finally, we achieved a general reduction in the root mean square error of the model prediction results and labels. Although there is no significant difference in Social Responsiveness Scale (SRS) scores before and after assisted therapy (p value = 0.60), in individual subjects (Sub. 1, Sub. 2 and Sub.3), the SRS total score is significantly reduced (Average drop of 19 points). These results demonstrate the effectiveness of prediction model based on RL and show the feasibility of assisted therapeutic system in children with autism.
近年来,辅助治疗越来越多地用于自闭症谱系障碍(ASD),以改善其社交互动和沟通能力。许多研究证明,互动游戏的形式对自闭症儿童的治疗有很好的效果。因此,我们的研究为ASD儿童提供了一个基于强化学习(RL)的辅助治疗系统,该系统有五个互动子游戏。众所周知,在治疗过程中有必要建立和维持令人信服的相互作用。因此,我们的目标是根据自闭症儿童的情绪来调整互动内容。然而,由于自闭症儿童的非典型和异常差异,大多数辅助系统都是基于小样本个体的离线训练和在线识别,因此现有的辅助系统在自动更新新映射的系统参数方面受到限制。采用强化学习与卷积神经网络(CNN)-支持向量回归(SVR)相结合的方法在线更新预测模型的权重。标准化情绪标签由治疗师评估。实验邀请了11名自闭症儿童作为实验对象,并拍摄了面部视频图像。实验持续5周的间歇辅助治疗,并对系统及治疗效果进行评价。最后,我们实现了模型预测结果和标签的均方根误差的普遍降低。虽然在辅助治疗前后,社会反应量表(SRS)得分没有显著差异(p值= 0.60),但在个体(Sub. 1, Sub. 2和Sub.3)中,SRS总分显著降低(平均下降19分)。这些结果证明了基于RL的预测模型的有效性,也表明了辅助治疗系统在自闭症儿童中的可行性。
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引用次数: 5
Lung segmentation method with dilated convolution based on VGG-16 network 基于VGG-16网络的扩张卷积肺部分割方法
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-12 DOI: 10.1080/24699322.2019.1649071
Lei Geng, Siqi Zhang, Jun Tong, Zhitao Xiao
Abstract Lung cancer has become one of the life-threatening killers. Lung disease need to be assisted by CT images taken doctor's diagnosis, and the segmented CT image of the lung parenchyma is the first step to help doctor diagnosis. For the problem of accurately segmenting the lung parenchyma, this paper proposes a segmentation method based on the combination of VGG-16 and dilated convolution. First of all, we use the first three parts of VGG-16 network structure to convolution and pooling the input image. Secondly, using multiple sets of dilated convolutions make the network has a large enough receptive field. Finally, the multi-scale convolution features are fused, and each pixel is predicted using MLP to segment the parenchymal region. Experimental results were produced over state of the art on 137 images which key metrics Dice similarity coefficient (DSC) is 0.9867. Experimental results show that this method can effectively segment the lung parenchymal area, and compared to other conventional methods better.
肺癌已成为危及生命的杀手之一。肺部疾病需要借助医生拍摄的CT图像辅助诊断,而肺实质的CT分割图像是帮助医生诊断的第一步。针对肺实质的准确分割问题,本文提出了一种基于VGG-16和扩张卷积相结合的肺实质分割方法。首先,我们利用VGG-16网络结构的前三部分对输入图像进行卷积和池化。其次,使用多组扩展卷积使网络具有足够大的接受域。最后,融合多尺度卷积特征,利用MLP对每个像素点进行预测,分割出实质区域。对137幅关键指标Dice相似系数(DSC)为0.9867的图像进行了实验。实验结果表明,该方法可以有效地分割肺实质区域,与其他常规方法相比效果更好。
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引用次数: 50
Clustering-based undersampling with random over sampling examples and support vector machine for imbalanced classification of breast cancer diagnosis 基于聚类的随机过采样样本下采样和支持向量机的乳腺癌症诊断不平衡分类
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-12 DOI: 10.1080/24699322.2019.1649074
Jue Zhang, Li Chen
Abstract To overcome the two-class imbalanced classification problem existing in the diagnosis of breast cancer, a hybrid of Random Over Sampling Example, K-means and Support vector machine (RK-SVM) model is proposed which is based on sample selection. Random Over Sampling Example (ROSE) is utilized to balance the dataset and further improve the diagnosis accuracy by Support Vector Machine (SVM). As there is one different sample selection factor via clustering that encourages selecting the samples near the class boundary. The purpose of clustering here is to reduce the risk of removing useful samples and improve the efficiency of sample selection. To test the performance of the new hybrid classifier, it is implemented on breast cancer datasets and the other three datasets from the University of California Irvine (UCI) machine learning repository, which are commonly used datasets in class imbalanced learning. The extensive experimental results show that our proposed hybrid method outperforms most of the competitive algorithms in term of G-mean and accuracy indices. Additionally, experimental results show that this method also performs superiorly for binary problems.
摘要针对癌症诊断中存在的两类分类不平衡问题,提出了一种基于样本选择的随机过采样、K-means和支持向量机(RK-SVM)混合模型。利用随机过采样实例(ROSE)对数据集进行平衡,进一步提高支持向量机(SVM)的诊断精度。因为通过聚类有一个不同的样本选择因素,它鼓励选择类边界附近的样本。这里聚类的目的是降低去除有用样本的风险,提高样本选择的效率。为了测试新的混合分类器的性能,它在癌症数据集和加州大学欧文分校(UCI)机器学习库的其他三个数据集上实现,这些数据集是类不平衡学习中常用的数据集。大量的实验结果表明,我们提出的混合方法在G-均值和精度指标方面优于大多数竞争算法。此外,实验结果表明,该方法对二元问题也有很好的处理效果。
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引用次数: 47
Novel joint algorithm based on EEG in complex scenarios 复杂场景下基于脑电的新型联合算法
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-10 DOI: 10.1080/24699322.2019.1649078
Dong-Wei Chen, Wei-Qi Yang, Rui Miao, Lan Huang, Liu Zhang, Chunjian Deng, Na Han
Abstract At present, in the field of electroencephalogram (EEG) signal recognition, the classification and recognition in complex scenarios with more categories of EEG signals have gained more attention. Based on the joint fast Fourier transform (FFT) and support vector machine (SVM) methods, this study proposed a novel EEG signal-processing joint method for the complex scenarios with 10 classifications of EEG signals. Moreover, a comprehensive efficiency formula was put forward. The formula considered the accuracy and time consumption of the joint method. This new joint method could improve the accuracy and comprehensive efficiency of multiclass EEG signal recognition. The new joint approach used standardization for data preprocessing. Feature extraction was performed by combining FFT and principal component analysis methods. EEG signals were classified using the weighted k-nearest nenighbour method. In this study, experiments were conducted using public datasets of brainwave 0-9 digits classification. The result demonstrated that the accuracy and comprehensive efficiency of the novel joint method were 84% and 87%, respectively, which were better than those of the existing methods. The precision rate, recall rate, and F1 score of the novel joint method were 89%, 85%, and 0.85, respectively. In conclusion, the proposed joint method was effective in a complex scenario for multiclass EEG signal recognition.
摘要目前,在脑电信号识别领域,脑电信号类别较多的复杂场景下的分类和识别越来越受到关注。基于联合快速傅立叶变换(FFT)和支持向量机(SVM)方法,本研究提出了一种新的脑电信号处理联合方法,用于10种脑电信号的复杂场景。此外,还提出了一个综合效率公式。该公式考虑了联合方法的精度和时间消耗。这种新的联合方法可以提高多类别脑电信号识别的准确性和综合效率。新的联合方法使用了数据预处理的标准化。采用FFT和主成分分析相结合的方法进行特征提取。EEG信号采用加权k近邻方法进行分类。在本研究中,使用脑电波0-9数字分类的公共数据集进行了实验。结果表明,新的联合方法的准确率和综合效率分别为84%和87%,优于现有方法。新的联合方法的准确率、召回率和F1得分分别为89%、85%和0.85。总之,所提出的联合方法在多类别脑电信号识别的复杂场景中是有效的。
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引用次数: 5
Automatic segmentation of arterial tree from 3D computed tomographic pulmonary angiography (CTPA) scans 三维计算机断层肺血管造影(CTPA)扫描中动脉树的自动分割
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-08-10 DOI: 10.1080/24699322.2019.1649077
Chi Zhang, Mingxia Sun, Yinan Wei, Hao Zhang, S. Xie, Tongxi Liu
Abstract Pulmonary embolism (PE) and other pulmonary vascular diseases, have been found associated with the changes in arterial morphology. To detect arterial changes, we propose a novel, fully automatic method that can extract pulmonary arterial tree in computed tomographic pulmonary angiography (CTPA) images. The approach is based on the fuzzy connectedness framework, combined with 3D vessel enhancement and Harris Corner detection to achieve accurate segmentation. The effectiveness and robustness of the method is validated in clinical datasets consisting of 10 CT angiography scans (6 without PE and 4 with PE). The performance of our method is compared with manual classification and machine learning method based on random forest. Our method achieves a mean accuracy of 92% when compared to manual reference, which is higher than the 89% accuracy achieved by machine learning. This performance of the segmentation for pulmonary arteries may provide a basis for the CAD application of PE.
摘要肺栓塞(PE)和其他肺血管疾病,已被发现与动脉形态的变化有关。为了检测动脉变化,我们提出了一种新的、全自动的方法,可以在计算机断层肺血管造影(CTPA)图像中提取肺动脉树。该方法基于模糊连通性框架,结合三维血管增强和Harris Corner检测实现精确分割。该方法的有效性和稳健性在由10次CT血管造影术扫描组成的临床数据集中得到了验证(6次无PE,4次有PE)。将该方法的性能与基于随机森林的人工分类和机器学习方法进行了比较。与手动参考相比,我们的方法实现了92%的平均准确率,高于机器学习实现的89%的准确率。肺动脉分割的这种性能可以为PE的CAD应用提供基础。
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引用次数: 13
期刊
Computer Assisted Surgery
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