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Optimization algorithm of association rule mining for heavy-haul railway freight train fault data based on distributed parallel computing. 基于分布式并行计算的重载货运列车故障数据关联规则挖掘优化算法。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-10-01 DOI: 10.1177/00368504241301181
Yanhui Bai, Honghui Li, Wengang Wang, Shufang Liu, Ning Zhang, Chun Zhang

With the continuous improvement in the efficiency of the heavy-haul railway freight transportation, the pressure on on-site maintenance is increasing. In-depth research on fault characteristics carries significant importance for fault scientific judgment and fault prevention. This study proposes an efficient association rule mining (ARM) algorithm, HM-RDHP, for analyzing fault data from heavy-haul railway freight trains. The algorithm introduces distributed parallel computing technology, integrating the MapReduce framework and HBase on the Hadoop platform to process large volumes of complex fault data efficiently. Experimental results show that the HM-RDHP algorithm can efficiently uncover hidden patterns and associations within the fault data of heavy-haul railway freight trains. The mined association rules provide a valuable reference model to aid in predictive maintenance and fault prevention strategies for freight train maintenance departments.

随着铁路重载货运效率的不断提高,现场维修的压力越来越大。深入研究故障特征对科学判断故障、预防故障具有重要意义。本文提出了一种高效的关联规则挖掘(ARM)算法HM-RDHP,用于重载铁路货运列车故障数据分析。该算法引入分布式并行计算技术,在Hadoop平台上集成MapReduce框架和HBase,高效处理海量复杂故障数据。实验结果表明,HM-RDHP算法可以有效地揭示重载货运列车故障数据中的隐藏模式和关联。挖掘出的关联规则为货运列车维护部门制定预测性维护和故障预防策略提供了有价值的参考模型。
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引用次数: 0
HXK, SnRK1, and TOR signaling in plants: Unraveling mechanisms of stress response and secondary metabolism. 植物中的HXK, SnRK1和TOR信号:揭示胁迫反应和次生代谢机制。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-10-01 DOI: 10.1177/00368504241301533
Seung Hee Eom, Eunhui Kim, Tae Kyung Hyun

As sessile photoautotrophs, plants constantly encounter diverse environmental stresses. Recent research has focused on elucidating sugar and energy signaling mediated by hexokinase (HXK), sucrose non-fermenting 1-related protein kinase 1 (SnRK1), and the target of rapamycin (TOR) and assessing its intricate interplay with hormones and secondary metabolism. HXK serves as a pivotal regulator of glucose sensing and metabolism. It affects plant growth and development in response to nutrient availability. SnRK1 acts as a vital energy sensor that regulates metabolic adjustments during stress to bolster plant resilience. Moreover, TOR integrates nutrient signals to finely modulate growth and development, balancing cellular metabolism and resource allocation. Understanding the functions of HXK, SnRK1, and TOR can provide profound insights into plant adaptation mechanisms and open promising avenues for leveraging biotechnological strategies to enhance the stress tolerance and nutritional value of crops. This narrative review focuses on recent advancements in the molecular mechanisms of HXK, SnRK1, and TOR and explores their potential applications in agricultural biotechnology.

作为无根的光自养生物,植物不断遭受各种环境胁迫。最近的研究主要集中在阐明己糖激酶(HXK)、蔗糖非发酵1相关蛋白激酶1 (SnRK1)和雷帕霉素(TOR)靶点介导的糖和能量信号,并评估其与激素和次级代谢的复杂相互作用。HXK是葡萄糖感知和代谢的关键调节因子。它通过对养分有效性的响应影响植物的生长发育。SnRK1作为一种重要的能量传感器,在逆境中调节代谢调节,增强植物的恢复力。此外,TOR整合营养信号,精细调节生长发育,平衡细胞代谢和资源分配。了解HXK、SnRK1和TOR的功能可以深入了解植物的适应机制,并为利用生物技术策略提高作物的抗逆性和营养价值开辟有希望的途径。本文综述了HXK、SnRK1和TOR的分子机制的最新进展,并探讨了它们在农业生物技术中的潜在应用。
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引用次数: 0
The synthesis and characterisation of derivatives of o-phenylenediamine and assessing their effectiveness in inhibiting corrosion for rust prevention. 邻苯二胺衍生物的合成、表征及对其防锈缓蚀效果的评价。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-10-01 DOI: 10.1177/00368504241305571
Zoltán Köntös

The corrosion of metals, particularly rust on iron and its alloys, poses significant challenges across industries, with notable economic and environmental consequences. Traditional rust prevention methods, reliant on chemical inhibitors and coatings, often raise concerns regarding their environmental and health impacts. In response, advancements in corrosion science have emphasized the potential of o-phenylenediamine (OPD) derivatives and vaseline-based mixtures as innovative, eco-friendly solutions. This article reviews the efficacy of OPD derivatives in mitigating anodic and cathodic reactions, thereby preventing rust formation by creating robust protective layers on metal surfaces. These derivatives act as physical barriers, impeding corrosive agents and offering versatile applications, including integration into protective coatings for new and existing metal structures. The synergistic combination of OPD with other inhibitors enhances protection, supporting sustainable practices by reducing resource consumption and environmental impact. Vaseline-based layers, while providing satisfactory initial hydrophobicity and ease of application, face challenges such as achieving uniform coverage on polar metal surfaces and preventing pore formation. Integrating Fe(III)(BTA)3 into vaseline coatings represents a paradigm shift in sustainable corrosion prevention, with a 30% concentration identified as optimal for maximum protection. This development marks a pivotal advancement in materials science, offering robust corrosion protection aligned with sustainability principles. The use of OPD derivatives introduces a novel, environmentally benign approach, leveraging their ability to adsorb onto metal surfaces and create protective layers against moisture and oxygen. This innovation aligns with global initiatives to reduce industrial environmental footprints, promoting sustainable, effective corrosion prevention strategies.

金属的腐蚀,尤其是铁及其合金的锈蚀,给各行各业带来了重大挑战,并带来了显著的经济和环境后果。传统的防锈方法依赖于化学抑制剂和涂层,经常引起人们对其环境和健康影响的担忧。因此,腐蚀科学的进步强调了邻苯二胺(OPD)衍生物和凡士林基混合物作为创新、环保解决方案的潜力。本文综述了OPD衍生物在减轻阳极和阴极反应方面的功效,从而通过在金属表面建立坚固的保护层来防止生锈。这些衍生物可以作为物理屏障,阻挡腐蚀剂,并提供多种应用,包括集成到新的和现有金属结构的保护涂层中。OPD与其他抑制剂的协同组合增强了保护,通过减少资源消耗和对环境的影响来支持可持续的做法。凡士林基层虽然提供了令人满意的初始疏水性和易于应用,但面临着诸如在极性金属表面均匀覆盖和防止孔隙形成等挑战。将Fe(III)(BTA)3整合到凡士林涂层中代表了可持续防腐的范式转变,30%的浓度被认为是最佳的保护效果。这一发展标志着材料科学的关键进步,提供符合可持续性原则的强大腐蚀保护。OPD衍生物的使用引入了一种新颖、环保的方法,利用它们在金属表面吸附的能力,形成抗湿、抗氧保护层。这一创新与减少工业环境足迹的全球倡议相一致,促进可持续、有效的防腐战略。
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引用次数: 0
Block cipher construction using minimum spanning tree from graph theory and its application with image encryption. 基于图论最小生成树的分组密码构造及其在图像加密中的应用。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-10-01 DOI: 10.1177/00368504241301534
Muhammad Waheed Rasheed, Abid Mahboob, Muhammad Bilal, Kiran Shahzadi

In modern cryptography, Substitution Boxes (S-boxes) are critical in introducing confusion into ciphertext, significantly enhancing encryption security. With the rising sophistication of hacking techniques, there is a growing need to develop stronger and more dynamic S-boxes. This paper proposes a novel method for constructing cryptographically secure S-boxes using graph theory, specifically based on the Minimum Spanning Tree (MST) of cycle graphs. The process begins by converting plaintext into vertices, forming a cycle graph. Special characters are incorporated, and ASCII-based values are assigned to vertices. The distance between vertices is calculated using their intersections, leading to the creation of an MST graph. The final step involves obtaining the adjacency matrix, which is further processed to generate the S-box. The S-box's unpredictability is enhanced by employing the S256 permutation from the symmetric group. Various cryptographic tests are conducted to evaluate the proposed S-box's performance, with results demonstrating its robustness when compared to existing S-box designs. Furthermore, this S-box is applied to an image encryption scheme, and its efficacy is thoroughly assessed. The findings highlight the potential of the proposed method to contribute significantly to cryptographic security.

在现代密码学中,替换盒(s -box)是引入密文混淆的关键,可以显著提高加密的安全性。随着黑客技术的日益成熟,越来越需要开发更强大、更动态的s -box。本文提出了一种基于循环图的最小生成树(MST)的图论构造密码安全s盒的新方法。该过程首先将明文转换为顶点,形成循环图。特殊字符被合并,基于ascii的值被分配给顶点。顶点之间的距离使用它们的交点来计算,从而创建一个MST图。最后一步是获取邻接矩阵,进一步处理生成s盒。S-box的不可预测性通过采用对称群中的S256排列得到增强。进行了各种密码测试来评估所提出的S-box的性能,结果表明,与现有的S-box设计相比,它具有鲁棒性。最后,将s盒算法应用于一种图像加密方案,并对其有效性进行了全面评估。这些发现突出了所提出的方法对加密安全做出重大贡献的潜力。
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引用次数: 0
Appropriate dose of tranexamic acid in the topical treatment of anterior epistaxis, 500 mg vs 1000 mg: A double-blind randomized controlled trial. 氨甲环酸局部治疗前鼻衄的适当剂量:500 毫克与 1000 毫克:双盲随机对照试验。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-10-01 DOI: 10.1177/00368504241264993
Cüneyt Arikan, Pınar Yeşim Akyol

Aims: Patients with epistaxis typically visit the emergency department for initial treatment. According to recent studies, tranexamic acid (TXA) is effective in the treatment of epistaxis. This study compared the therapeutic superiority of saline to that of 500 and 1000 mg doses of topical TXA for the treatment of anterior epistaxis. Materials and methods: This phase 4 clinical trial was a randomized, controlled, and double-blind trial. A total of 152 patients were divided into three groups. Group 1 was treated with 1000 mg TXA, Group 2 with 500 mg TXA, and Group 3 with saline. Results: Based on multinomial logistic regression analysis, the bleeding frequency at the 5th minute was 2.9 times and rebleeding status was 4.3 times less in Group 1 (1000 mg TXA) than in Group 3 (saline). There were no differences between the three groups in terms of side effects or salvage therapy. Conclusion: In addition to its superiority in treatment, 1000 mg of TXA is recommended because of the decreased rate of recurrent bleeding and low incidence of side effects.

目的:鼻衄患者通常会到急诊科接受初步治疗。根据最近的研究,氨甲环酸(TXA)可有效治疗鼻衄。本研究比较了生理盐水与 500 毫克和 1000 毫克剂量的局部氨甲环酸治疗前鼻衄的疗效优劣。材料和方法:这项 4 期临床试验是一项随机、对照和双盲试验。共有 152 名患者被分为三组。第一组使用 1000 毫克 TXA,第二组使用 500 毫克 TXA,第三组使用生理盐水。结果根据多项式逻辑回归分析,第 1 组(1000 毫克 TXA)在第 5 分钟的出血频率是第 3 组(生理盐水)的 2.9 倍,再出血情况是第 3 组(生理盐水)的 4.3 倍。三组在副作用和挽救治疗方面没有差异。结论1000 毫克 TXA 除了在治疗方面具有优势外,还因其降低了复发出血率和副作用发生率而受到推荐。
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引用次数: 0
Ultrasound-based prevalence of polyvascular disease and its association with adverse outcome in patients undergoing coronary artery bypass grafting. 接受冠状动脉旁路移植手术的患者中基于超声的多血管疾病患病率及其与不良预后的关系。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-10-01 DOI: 10.1177/00368504241297206
Junyi Gao, Yi Cheng

Objective: Polyvascular disease (polyVD) often coexists with coronary artery disease (CAD). We aim to investigate the prevalence of polyVD using the method of ultrasound and find its association with adverse outcomes in coronary artery bypass grafting (CABG) patients. Methods: This retrospective and cross-sectional study included 1344 patients with a mean age of 61.4 years. Presence of peripheral artery atherosclerotic plaque and stenosis was assessed using the method of ultrasound. Receiver operating characteristic (ROC) analysis and multivariate logistic regression analysis were performed to investigate the association of polyVD with in-hospital all-cause death. Results: 52.1% of the patients had polyVD and among which 31.9% had one additional arterial bed involvement and 20.2% had two or three additional arterial beds involvement. Patients with two or three involved arterial beds had worse baseline characteristics. In-hospital all-cause death rate increased with the number of involved arterial beds (1.1% in patients with only CAD vs 3.7% in patients with two or three involved arterial beds), and this trend was more prominent in elderly patients. Multivariate logistic regression analysis confirmed that polyVD patients with two or three involved arterial beds had about three times the risk for all-cause death. Conclusions: Prevalence of polyVD assessed by ultrasound was high in CABG patients and it was significantly associated with in-hospital all-cause death. Our study may provide additive information for preoperative risk stratification in CABG patients.

目的:多血管疾病(polyvascular disease,polyVD)通常与冠状动脉疾病(CAD)并存。我们旨在利用超声波方法调查多血管病变的发生率,并发现其与冠状动脉旁路移植术(CABG)患者不良预后的关联。方法:这项回顾性横断面研究共纳入 1344 名患者,平均年龄为 61.4 岁。使用超声波方法评估了外周动脉粥样硬化斑块和狭窄的存在情况。研究人员进行了接收器操作特征(ROC)分析和多变量逻辑回归分析,以探讨多发性动脉粥样硬化与院内全因死亡的关系。结果显示52.1%的患者患有多发性动脉粥样硬化,其中31.9%的患者有一个额外的动脉床受累,20.2%的患者有两个或三个额外的动脉床受累。有两个或三个动脉床受累的患者基线特征较差。院内全因死亡率随着受累动脉床数量的增加而增加(仅有CAD的患者为1.1%,而有两到三个受累动脉床的患者为3.7%),这一趋势在老年患者中更为明显。多变量逻辑回归分析证实,有两个或三个动脉床受累的多发性血管疾病患者的全因死亡风险大约是其他患者的三倍。结论在 CABG 患者中,超声评估的多内脏病变发生率很高,且与院内全因死亡有显著相关性。我们的研究可为 CABG 患者的术前风险分层提供补充信息。
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引用次数: 0
The quantifying, mapping, and risk analysis of human-related stressors in the high seas. 对公海中与人类有关的压力因素进行量化、绘图和风险分析。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-10-01 DOI: 10.1177/00368504241288373
Chang Zhao, Miaozhuang Zheng, Yuejing Ge

Objectives: Marine biodiversity and ecosystem services in the high seas are threatened by numerous stress factors caused by human activities, including global shipping, high-sea fishing, marine plastic pollution, and anthropogenic climate change. Socioeconomic factors are one of the criteria for the establishment of area-based management tools in the high seas for marine biodiversity conservation beyond national jurisdiction. The aim of the work is to propose a spatiotemporal approach to identify risks from marine human activities and recommendations for high seas governance. Methods: Data related to human activities from 2014 to 2022 were used to calculate the distribution and changes of human-related stressors, and the risk to marine biodiversity in the high seas caused by human activities. Results: The North Atlantic, Philippine Sea, Arabian Sea, Bay of Bengal, and East Central Atlantic show high and increasing intensities of human-related stressors, and are therefore particularly at need for the protection and conservation of marine biodiversity. Risks from human activities vary within the marine areas that are prioritized for biodiversity protection. The study recommends that the designation of high seas protected areas should take into account the types of risks to which the different marine areas are exposed, and that the high seas protected areas should be established gradually. At the same time, appropriate management measures should be formulated according to the intensity of human activities in the different marine areas. Conclusions: Quantifying and classifying the risk from human-related stressors could help identify solution for the protection and conservation and facilitate the marine spatial planning, establishment area based management tools, including marine protected areas in the high seas.

目标:公海的海洋生物多样性和生态系统服务受到人类活动造成的众多压力因素的威胁,包括全球航运、公海捕鱼、海洋塑料污染和人为气候变化。社会经济因素是在公海建立区域管理工具以保护国家管辖范围以外海洋生物多样性的标准之一。这项工作旨在提出一种时空方法,以确定海洋人类活动带来的风险,并为公海治理提出建议。方法:利用 2014 年至 2022 年与人类活动有关的数据,计算与人类有关的压力源的分布和变化,以及人类活动对公海海洋生物多样性造成的风险。研究结果北大西洋、菲律宾海、阿拉伯海、孟加拉湾和中东部大西洋显示出与人类活动相关的压力因素较高,且强度不断增加,因此特别需要保护和养护海洋生物多样性。在优先保护生物多样性的海域内,人类活动造成的风险各不相同。研究建议,公海保护区的指定应考虑到不同海域所面临的风险类型,并应逐步建立公海保护区。同时,应根据不同海域的人类活动强度制定适当的管理措施。结论:对与人类有关的压力因素所造成的风险进行量化和分类,有助于确定保护和养护的解决方案,并促进海洋空间规划、建立以区域为基础的管理工具,包括公海海洋保护区。
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引用次数: 0
Development of a rapid method for the simultaneous determination of aminophylline, doxofylline, bromhexine, and ambroxol by HPLC. 利用高效液相色谱法建立同时测定氨茶碱、多索茶碱、溴己新和氨溴索的快速方法。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-10-01 DOI: 10.1177/00368504241296305
Xia Meng, Yunxia Feng, Fuchao Chen, Ming Shi, Baoxia Fang

Introduction: Antitussive and expectorant drugs such as aminophylline (APL), doxofylline (DXL), bromhexine hydrochloride (BXH), and ambroxol hydrochloride (AXH), either individually or in combination, are widely used in the prevention and treatment of respiratory diseases. The study aimed to establish a high-performance liquid chromatography (HPLC) method for the simultaneous determination of these four drugs and to investigate their stability in 0.9% sodium chloride injection or 5% glucose injection over 48 hours. Methods: An InertSustain C18 column (150 mm × 4.6 mm, 5 μm) was used. The mobile phase consisted of acetonitrile and 50 mmol·L-1 potassium dihydrogen phosphate solution (pH 4.0) with gradient elution. The flow rate was 0.8 mL·min-1, and the column temperature was maintained at 30°C. The stability of APL, DXL, BXH, and AXH in 0.9% sodium chloride and 5% glucose injections over 48 h was determined using HPLC. Results: APL, DXL, BXH, and AXH showed good linearity within the ranges of 0.01 to 0.20, 0.003-0.06, 0.015-0.30, and 0.016-0.16 mg·mL-1, respectively (r > 0.999). The intraday and interday relative standard deviations were <2%, with recovery rates between 98.4% and 102.2%. The four drugs remained colorless and clear in infusion mixtures. The pH value fluctuated within ±0.3 over 48 hours, and the relative percentage content of the drugs ranged from 95.0% to 105.0%. Conclusion: The established HPLC method is simple, reliable, and stable, allowing for the simultaneous determination of the four antitussive and expectorant drugs. APL, DXL, BXH, and AXH were stable within 48 hours when mixed with 0.9% sodium chloride and 5% glucose injections.

简介氨茶碱(APL)、多索茶碱(DXL)、盐酸溴己新(BXH)和盐酸氨溴索(AXH)等镇咳祛痰药物单独或联合使用可广泛用于预防和治疗呼吸系统疾病。本研究旨在建立一种高效液相色谱(HPLC)方法,用于同时测定这四种药物,并考察它们在 0.9% 氯化钠注射液或 5% 葡萄糖注射液中 48 小时的稳定性。方法:采用 InertSustain C18 色谱柱:采用 InertSustain C18 色谱柱(150 mm × 4.6 mm,5 μm)。流动相为乙腈和 50 mmol-L-1 磷酸二氢钾溶液(pH 4.0),梯度洗脱。流速为 0.8 mL-min-1,柱温保持在 30°C。使用高效液相色谱法测定了 APL、DXL、BXH 和 AXH 在 0.9% 氯化钠和 5% 葡萄糖注射液中 48 小时的稳定性。结果APL、DXL、BXH 和 AXH 分别在 0.01 至 0.20、0.003 至 0.06、0.015 至 0.30 和 0.016 至 0.16 mg-mL-1 的范围内表现出良好的线性关系(r > 0.999)。日内和日间相对标准偏差为结论:所建立的高效液相色谱法简单、可靠、稳定,可同时测定四种止咳祛痰药物。APL、DXL、BXH 和 AXH 与 0.9% 氯化钠和 5% 葡萄糖注射液混合后,在 48 小时内稳定。
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引用次数: 0
Pimozide-loaded nanostructured lipid carriers: Repurposing strategy against lung cancer. 装载了匹莫齐特的纳米结构脂质载体:针对肺癌的再利用战略
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-10-01 DOI: 10.1177/00368504241296304
Wafa' A Al-Haj, Hamdi Nsairat, Mohamed El-Tanani

Objective: This study aimed to repurpose pimozide (PMZ) by incorporating it into nanostructured lipid carriers (NLC) using a modified melting emulsion ultrasonication method.

Methods: We employed stearic and oleic acids in a 1:1 ratio as lipids, with Tween 80 and PEG 4000 as surfactants. The formulation was analyzed for particle size, zeta potential, and encapsulation efficiency. Transmission electron microscopy (TEM) was used to confirm the spherical shape of the particles. The release profile of PMZ-NLC was evaluated under different pH conditions, and anticancer activity was tested on A549 cell lines.

Results: The PMZ-NLC exhibited an average particle size of 136 ± 2.9 nm, a zeta potential of -25.1 ± 0.9 mV, and an encapsulation efficiency of 86% ± 11. TEM confirmed the spherical shape of the NLCs. PMZ release from PMZ-NLC was pH-sensitive, enhancing tumor targeting. IC50 values were 16.5 μM for free PMZ and 12.9 μM for PMZ-NLC after 72 h.

Discussion: PMZ-NLC demonstrated improved anticancer activity compared to free PMZ, suggesting that encapsulation enhances the drug's effectiveness. The pH-sensitive release profile supports its potential for targeted therapy in lung cancer.

Conclusions: PMZ-NLC showed potential as a safe and effective strategy for lung cancer treatment. Further investigation is warranted to evaluate its in vivo efficacy, long-term safety, and clinical application.

目的:本研究旨在利用改良的熔融乳化超声法,将匹莫齐特(PMZ)加入纳米结构脂质载体(NLC)中,从而实现其再利用:本研究旨在利用改良熔融乳液超声法将匹莫齐特(PMZ)加入纳米结构脂质载体(NLC)中,从而实现其再利用:我们采用硬脂酸和油酸以 1:1 的比例作为脂质,Tween 80 和 PEG 4000 作为表面活性剂。对配方的粒度、ZETA电位和封装效率进行了分析。透射电子显微镜(TEM)确认了颗粒的球形。评估了 PMZ-NLC 在不同 pH 值条件下的释放曲线,并对 A549 细胞系进行了抗癌活性测试:结果:PMZ-NLC的平均粒径为136 ± 2.9 nm,zeta电位为-25.1 ± 0.9 mV,封装效率为86% ± 11。TEM确认了NLC的球形。PMZ-NLC的PMZ释放对pH值敏感,从而增强了肿瘤靶向性。72小时后,游离PMZ的IC50值为16.5 μM,而PMZ-NLC的IC50值为12.9 μM:讨论:与游离 PMZ 相比,PMZ-NLC 的抗癌活性有所提高,这表明封装可增强药物的有效性。对 pH 值敏感的释放特征支持了其用于肺癌靶向治疗的潜力:PMZ-NLC显示出作为一种安全有效的肺癌治疗策略的潜力。结论:PMZ-NLC作为一种安全有效的肺癌治疗策略具有潜力,但还需要进一步研究,以评估其体内疗效、长期安全性和临床应用。
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引用次数: 0
A comparison between single and fractionated doses of albumin-bound paclitaxel in the treatment of advanced esophageal cancer: A multicenter case-control study. 白蛋白结合型紫杉醇治疗晚期食管癌的单次剂量与分次剂量比较:一项多中心病例对照研究。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-10-01 DOI: 10.1177/00368504241299016
Jing Ren, Ke Wang, Jian Zhao, Chang Xu, Changqing Liu, Yusheng Wang, Guangyu Wang

Purpose: At present, albumin-bound paclitaxel combined with platinum is the standard first-line treatment option for advanced esophageal cancer (EC). However, following a hospitalization surge, clinicians may prefer to use albumin-bound paclitaxel as a single dose. The present study aimed to investigate the survival of patients with advanced EC when treated with single or fractionated doses of albumin-bound paclitaxel.

Methods: We collected survival data of patients with advanced first-line EC who had used albumin-bound paclitaxel with or without other treatment regimens from January 2018 to September 2023 at the Harbin Medical University Cancer Hospital and the Shanxi Province Cancer Hospital. The patients were divided into two groups according to the frequency and dose of albumin-bound paclitaxel administration, namely the abraxane fractional administration group (A group, 27 patients) and the abraxane single administration group (B group, 182 patients).

Results: The median progression-free survival (PFS) was 9.0 months in both groups (p = 0.35), and the median overall survival (OS) was 21.0 months in A group and 18.0 months in B group (p = 0.61). The objective response rate was 37% in A group and 25% in B group (p = 0.314), and the disease control rate was 89% in A group and 83% in B group (p = 0.580). The incidence of grade 3 or higher treatment-related adverse events was 15% in both groups.

Conclusion: Albumin-bound paclitaxel treatments showed no statistically significant differences in the PFS or OS. They were considered safe, whether administered as a single dose or in fractionated doses.

目的:目前,白蛋白结合紫杉醇联合铂是晚期食管癌(EC)的标准一线治疗方案。然而,在住院治疗激增后,临床医生可能更倾向于使用白蛋白结合型紫杉醇单剂量治疗。本研究旨在探讨晚期食管癌患者接受单剂量或分次剂量白蛋白结合型紫杉醇治疗后的生存情况:我们收集了2018年1月至2023年9月在哈尔滨医科大学附属肿瘤医院和山西省肿瘤医院使用白蛋白结合型紫杉醇联合或不联合其他治疗方案的晚期一线EC患者的生存数据。根据白蛋白结合型紫杉醇给药频率和剂量将患者分为两组,即阿糖胞苷分次给药组(A组,27例患者)和阿糖胞苷单次给药组(B组,182例患者):两组患者的中位无进展生存期(PFS)均为9.0个月(P=0.35),中位总生存期(OS)分别为A组21.0个月和B组18.0个月(P=0.61)。客观反应率 A 组为 37%,B 组为 25%(P = 0.314);疾病控制率 A 组为 89%,B 组为 83%(P = 0.580)。两组中3级或以上治疗相关不良反应的发生率均为15%:结论:白蛋白结合型紫杉醇治疗的PFS和OS差异无统计学意义。无论是单次给药还是分次给药,它们都被认为是安全的。
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