Journal of Herbal Medicine最新文献_第8页

The use of herbal medicine for hypertension in rural and urban Thailand: a cross sectional study 泰国城乡居民使用草药治疗高血压的情况：横断面研究

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-07-17 DOI: 10.1016/j.hermed.2024.100916

Nutchar Wiwatkunupakarn , Chanchanok Aramrat , Pimtip Sanguanwai , Yanee Choksomngam , Mary E. Gilder , Wichuda Jiraporncharoen , Rose McGready , Chaisiri Angkurawaranon

Introduction

Using herbal medicine to treat hypertension is common in Thailand. However, there is variation in the use of herbs between rural and urban areas. This study aims to observe the prevalence of herb use, describe herb users’ behaviours, and describe anti-hypertensive drug compliance among the users.

Methods

A cross-sectional survey among hypertensive patients visiting primary care services in Tak (rural) and Chiang Mai (urban) provinces was conducted between March and April 2019. Patients were assessed by using questionnaires that gathered information about patient demographic data, history of hypertension, herb use behaviours, and the concurrent use of standard treatment.

Results

In total, 400 participants were included in this study—200 from rural and 200 from urban areas. Sixty-two percent were female. The prevalence of herb use was 13.0% in urban areas and 17.5% in the rural areas. Rural participants reported a significantly longer duration of herb use (P < 0.01), and a significantly higher proportion of using unapproved herbal products (91% vs 54%, P < 0.001). Participants mostly use herbs along with standard treatment (86.9%); nevertheless, poor drug compliance was similar in both areas, with rural participants more frequently taking their medications at the wrong time (P = 0.03).

Conclusion

There was a trend of higher use of unapproved herbals in rural participants. Drug compliance among herb users was poor. It is recommended that a comprehensive assessment of herb use is conducted during care for hypertensive patients in this and similar contexts.

导言使用草药治疗高血压在泰国很常见。然而，农村和城市地区在使用草药方面存在差异。本研究旨在观察草药使用的普遍程度，描述草药使用者的行为，并说明使用者服用抗高血压药物的依从性。方法 2019年3月至4月期间，在德府（农村）和清迈府（城市）的基层医疗服务机构对高血压患者进行了横断面调查。调查问卷收集了患者的人口统计学数据、高血压病史、草药使用行为以及同时使用标准治疗的情况。女性占 62%。城市地区使用草药的比例为 13.0%，农村地区为 17.5%。农村参与者使用草药的时间明显更长（P <0.01），使用未经批准的草药产品的比例明显更高（91% 对 54%，P <0.001）。参与者大多在接受标准治疗的同时使用草药（86.9%）；然而，两个地区的服药依从性都很差，农村参与者更常在错误的时间服药（P = 0.03）。草药使用者的服药依从性很差。建议在该地区及类似地区对高血压患者进行护理时对草药使用情况进行全面评估。

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引用次数: 0

A review on ethnomedicine, phytochemistry, pharmacology, and toxicology of Pedalium murex L. "Pedalium murex L 的民族医药学、植物化学、药理学和毒理学综述"。

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-07-17 DOI: 10.1016/j.hermed.2024.100917

Amrender Singh Rao, Surender Singh Yadav, Neetu Singh, Abhishek Nandal

Introduction

Pedalium murex L. (Gokhru) is a succulent herbaceous plant with multifarious medicinal values in various traditional therapeutic systems. The review summarises the previous research findings on P. murex, with major emphasis on ethnomedicine, phytochemistry, pharmacology, and toxicology.

Material and methods

The study was performed by retrieving relevant literature from scientific databases like Scopus, Science Direct, Springer Link, Wiley, PubMed, Google Scholar, Elsevier, and Web of Science. The data collection was carried out using specific keywords like ‘P. murex,’ ‘Gokhru,’ ‘ethnomedicinal uses,’ ‘Phytochemistry,’ ‘Pharmacology,’ ‘Toxicity,’ ‘Clinical studies’ and their combinations.

Results

The study's findings revealed a strong connection between P. murex traditional use and pharmacological activities. The plant shows aphrodisiac, antiulcer, anti-inflammatory, antioxidant, antimicrobial, antidiabetic, antivenereal, anticancer, analgesic, antipyretic, immune-modulator, and other pharmacological properties. Phytocompounds like diosgenin, pedalin, pedalitin, β-sitosterol, isatin, lupeol acetate, and ursolic acid are amongst the many which are responsible for various therapeutic applications and have the potential to transform into oral drugs.The plant shows immune-modulatory effects by influencing corticosterone, low-density lipoprotein, thiobarbituric acid, lipid peroxidation, nitric oxide, exo-polysaccharides, Cyclooxygenase and free radical inhibitory mechanisms for neuroprotection, hypolipidemic, antidiabetic, antibiofilm, aphrodisiac, and anti-inflammatory activities respectively. Toxicological studies implied safety and protection indicating potential to be used as herbal medicine.

Conclusion

The different parts of the plant have potential bioactive properties with prospective ethnopharmacological relevance for aphrodisiac, venereal, urinary tract infections and inflammation. Further, it is necessary to conduct controlled clinical trials, in-depth pharmacokinetic, detailed phytochemical and pharmacological studies to achieve the plant’s full potential.

引言 Pedalium murex L.（Gokhru）是一种肉质草本植物，在各种传统治疗系统中具有多种药用价值。本综述总结了以前关于 P. murex 的研究成果，主要侧重于民族医药学、植物化学、药理学和毒理学。材料与方法本研究通过检索 Scopus、Science Direct、Springer Link、Wiley、PubMed、Google Scholar、Elsevier 和 Web of Science 等科学数据库中的相关文献进行。数据收集使用了特定的关键词，如 "P. murex"、"Gokhru"、"民族药用"、"植物化学"、"药理学"、"毒性"、"临床研究 "及其组合。该植物具有壮阳、抗溃疡、抗炎、抗氧化、抗菌、抗糖尿病、抗蛇毒、抗癌、镇痛、解热、免疫调节等药理特性。许多植物化合物，如 diosgenin、pedalin、pedalitin、β-谷甾醇、isatin、lupeol acetate 和熊果酸等，都具有多种治疗作用，并有可能转化为口服药物。该植物通过影响皮质酮、低密度脂蛋白、硫代巴比妥酸、脂质过氧化、一氧化氮、外多糖、环氧化酶和自由基抑制机制，显示出免疫调节作用，分别具有神经保护、降血脂、抗糖尿病、抗生物膜、壮阳和抗炎活性。毒理学研究表明，该植物的不同部分具有潜在的生物活性，在壮阳、性病、尿路感染和炎症方面具有民族药理学意义。此外，有必要进行对照临床试验、深入的药代动力学、详细的植物化学和药理学研究，以充分发挥该植物的潜力。

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引用次数: 0

Optimisation and Evaluation of the Correlation of Extraction Conditions for Total Flavonoid Content and Antixanthine Oxidase Activity in Psidium guajava 优化和评估萃取条件对番石榴总黄酮含量和抗黄嘌呤氧化酶活性的相关性

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-07-14 DOI: 10.1016/j.hermed.2024.100915

T.M. Le , C.D.P. Nguyen , A.C. Ha

Introduction

Psidium guajava L. (P guajava) and its leaf, one of the most popular plants in traditional medicine and cuisine, were demonstrated to have high flavonoid content with many bioactivities, including antigout activity. However, the correlation between total flavonoid content (TFC) and antigout activities and the optimal conditions for extracting P guajava have not been reported.

Methods

This study established the optimisation of ethanol extracts of P guajava leaves for TFC and antigout activities using the single-factor method and response surface methodology. The antigout activities were determined through the xanthine oxidase inhibition (XOI) method.

Results

The four independent variables (ethanol concentration, plant-solvent ratio, extraction time, and temperature) significantly impacted two response variables (TFC and XOI activity). The optimal extracts for XOI activity reach the maximum TFC of 323.86 ± 2.26 mg quercetin/g and XOI activity of 26.37 ± 0.5 μg/ml. The changes in the chemical structure of extracts were analysed by Fourier transform infrared, which indicated that several flavonoids in P guajava do not have XOI activity. The correlation of TFC and XOI is robust with the Pearson correlation of −0.882 and Spearman Rho test of −0.884. Additionally, the biological activities, such as antioxidant and anti-inflammatory, of optimal extracts for XOI and TFC were determined to extend the application capacity to support the treatment of gout diseases.

Conclusions

The optimised extraction conditions are critical to isolating flavonoids, which can serve as functional food or medicine for managing gout and its complications.

引言番石榴（Psidium guajava L.）及其叶片是传统医学和烹饪中最受欢迎的植物之一，其黄酮类化合物含量高，具有多种生物活性，包括抗痛风活性。本研究采用单因素法和响应面法对番石榴叶乙醇提取物的总黄酮含量和抗痛风活性进行了优化。结果四个自变量（乙醇浓度、植物-溶剂比率、提取时间和温度）对两个响应变量（TFC 和 XOI 活性）有显著影响。XOI 活性的最佳提取物达到了最大 TFC（323.86 ± 2.26 毫克槲皮素/克）和 XOI 活性（26.37 ± 0.5 微克/毫升）。通过傅立叶变换红外光谱分析了提取物化学结构的变化，结果表明番石榴中的几种黄酮类化合物不具有 XOI 活性。TFC 与 XOI 的相关性很强，Pearson 相关性为-0.882，Spearman Rho 检验为-0.884。此外，还确定了 XOI 和 TFC 最佳提取物的抗氧化和抗炎等生物活性，以扩大其应用能力，支持痛风疾病的治疗。

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引用次数: 0

Corrigendum to “Effect of Lantana camara ethanolic leaf extract on survival and migration of MDA-MB-231 triple-negative breast cancer cell line” [Journal of Herbal Medicine 43 (2024) 100837] 香蒲乙醇叶提取物对 MDA-MB-231 三阴性乳腺癌细胞系存活和迁移的影响》[《中草药杂志》43 (2024) 100837]更正

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-07-13 DOI: 10.1016/j.hermed.2024.100910

Arundhaty Pal, Sourav Sanyal, Sayantani Das, Tapas K. Sengupta

引用次数: 0

Can herbal teas be used as complementary therapies for kidney disorders? Results from a cross-sectional study 草药茶可以作为肾脏疾病的辅助疗法吗？横断面研究结果

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-07-09 DOI: 10.1016/j.hermed.2024.100914

Firouzeh Moeinzadeh , Mohammad Hossein Rouhani , Mojgan Mortazavi , Farnaz Shahdadian

Introduction

Chronic kidney disease (CKD) has limited treatment options and is becoming more and more common. Since apparent evidence in the literature shows that herbs may be reno-protective, we discussed different kinds of herbal tea in relation to CKD and related disorders.

Methods

This cross-sectional study was conducted in health care centres located in a region in central Iran by enroling subjects aged 18 years and older. A self-reported questionnaire was used to evaluate the frequency and type of herbal tea drinks by participants. Anthropometric characteristics were measured and blood samples were obtained using a standard procedure. The Kidney Disease Outcome Quality Initiative (K/DOQI) guideline was the reference for diagnosis of CKD. Through multiple logistic models, the association between herbal tea drinking with CKD and related disorders was examined.

Results

Overall, 3 322 subjects were examined in this study. Three types of herbal tea were consumed by the study participants including green tea, chamomile-thyme tea, and borage tea. No statistically significant consistent associations between kidney disorders, including CKD, haematuria, albuminuria, and kidney stone and consumption of these herbal preparations were identified.

Conclusion

Overall, this study failed to suggest any consistent association between renal function and three categories of herbal tea in adult Iranian individuals.

引言慢性肾脏病（CKD）的治疗方法有限，而且越来越常见。由于文献中有明显证据表明草药可能具有肾脏保护作用，因此我们讨论了不同种类的草药茶与 CKD 及相关疾病的关系。研究采用自我报告问卷调查法评估受试者饮用凉茶的频率和类型。采用标准程序测量了人体测量特征并采集了血液样本。肾脏疾病结果质量倡议（K/DOQI）指南是诊断慢性肾脏病的参考标准。通过多重逻辑模型，研究了饮用凉茶与 CKD 及相关疾病之间的关系。研究对象饮用了三种花草茶，包括绿茶、洋甘菊-百里香茶和琉璃苣茶。结论总体而言，这项研究未能表明伊朗成年人的肾功能与三类草药茶之间存在任何一致的联系。

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引用次数: 0

Comparative Study on the Effects of Myrtle and Chamomile Essential Oils on Pain and Episiotomy Wound Healing in Primiparous Women: A Randomised Controlled Clinical 桃金娘精油和洋甘菊精油对初产妇疼痛和外阴切开术伤口愈合影响的比较研究：随机对照临床研究

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-07-04 DOI: 10.1016/j.hermed.2024.100913

S. Moradkhani , S. Abdoli , E.T. Ghane , E. Jenabi

Introduction

Episiotomy is a common surgical procedure that affects the quality of life of women. Chamomile and myrtle have been used to treat wounds since antiquity. This study aimed to compare the effects of topical formulations containing essential oils (EOs) of chamomile, myrtle, , or a placebo on pain intensity and episiotomy wound healing in primiparous women.

Methods

This randomised and controlled clinical trial was conducted in the city of Hamadan in 2020. To this end, 120 parturient mothers were randomly assigned to one of three groups. They applied topical formulations containing 1% EO of chamomile, myrtle, or placebo twice daily for 10 days. Data collection was subsequently performed by assessing demographic, gynaecological, possible signs of side effects, pain intensity, and the wound-healing process 6 hours after surgery, days fifth and tenth after the intervention. In addition, the Visual Analogue Scale and Redness, Oedema, Ecchymosis, Discharge, and Approximation were utilised to examine pain intensity and healing processes. R software (v. 4.0.5) was employed for data analysis. The statistical significance level was P < 0.05.

Results

There was no significant difference between groups at baseline. Furthermore, the mean pain intensity score in the three groups indicated no statistically significant differences. The group that received chamomile experienced the best wound-healing process (P < 0.05) on the 10th day. Phytochemical investigations revealed the presence of α-bisabolol oxide A, α-bisabolol oxide B, β-farnesene, and chamazulene in chamomile EO, and α-pinene, 1,8-cineol, linalool, α-terpineol, linalool acetate, and limonene in myrtle EO.

Conclusions

A chamomile-containing formulation may promote episiotomy healing.

导言开腹手术是一种影响妇女生活质量的常见外科手术。洋甘菊和桃金娘自古以来就被用来治疗伤口。本研究旨在比较含有洋甘菊、桃金娘精油（EO）或安慰剂的外用配方对初产妇疼痛强度和外阴切开术伤口愈合的影响。方法这项随机对照临床试验于 2020 年在哈马丹市进行。为此，120 名产妇被随机分配到三组中的一组。她们使用含 1%洋甘菊、桃金娘或安慰剂的外用制剂，每天两次，持续 10 天。随后通过评估人口统计学、妇科、可能出现的副作用迹象、疼痛强度以及术后 6 小时、干预后第五天和第十天的伤口愈合过程来收集数据。此外，还使用了视觉模拟量表和红肿、水肿、瘀斑、脱落和接近度来检查疼痛强度和愈合过程。数据分析采用了 R 软件（4.0.5 版）。统计显著性水平为 P < 0.05。此外，三组的平均疼痛强度评分在统计学上也无明显差异。接受洋甘菊治疗的组在第 10 天的伤口愈合情况最好（P < 0.05）。植物化学调查显示，洋甘菊环氧乙烷中含有α-氧化二羟基苯乙醇A、α-氧化二羟基苯乙醇B、β-法呢烯和洋甘菊烯，桃金娘环氧乙烷中含有α-蒎烯、1,8-松油醇、芳樟醇、α-松油醇、乙酸芳樟醇酯和柠檬烯。

{"title":"Comparative Study on the Effects of Myrtle and Chamomile Essential Oils on Pain and Episiotomy Wound Healing in Primiparous Women: A Randomised Controlled Clinical","authors":"S. Moradkhani , S. Abdoli , E.T. Ghane , E. Jenabi","doi":"10.1016/j.hermed.2024.100913","DOIUrl":"10.1016/j.hermed.2024.100913","url":null,"abstract":"<div><h3>Introduction</h3><p>Episiotomy is a common surgical procedure that affects the quality of life of women. Chamomile and myrtle have been used to treat wounds since antiquity. This study aimed to compare the effects of topical formulations containing essential oils (<strong>EOs</strong>) of chamomile, myrtle, , or a placebo on pain intensity and episiotomy wound healing in primiparous women.</p></div><div><h3>Methods</h3><p>This randomised and controlled clinical trial was conducted in the city of Hamadan in 2020. To this end, 120 parturient mothers were randomly assigned to one of three groups. They applied topical formulations containing 1% EO of chamomile, myrtle, or placebo twice daily for 10 days. Data collection was subsequently performed by assessing demographic, gynaecological, possible signs of side effects, pain intensity, and the wound-healing process 6 hours after surgery, days fifth and tenth after the intervention. In addition, the Visual Analogue Scale and Redness, Oedema, Ecchymosis, Discharge, and Approximation were utilised to examine pain intensity and healing processes. R software (v. 4.0.5) was employed for data analysis. The statistical significance level was <em>P</em> < 0.05.</p></div><div><h3>Results</h3><p>There was no significant difference between groups at baseline. Furthermore, the mean pain intensity score in the three groups indicated no statistically significant differences. The group that received chamomile experienced the best wound-healing process (<em>P</em> < 0.05) on the 10th day. Phytochemical investigations revealed the presence of α-bisabolol oxide A, α-bisabolol oxide B, β-farnesene, and chamazulene in chamomile EO, and α-pinene, 1,8-cineol, linalool, α-terpineol, linalool acetate, and limonene in myrtle EO.</p></div><div><h3>Conclusions</h3><p>A chamomile-containing formulation may promote episiotomy healing.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"46 ","pages":"Article 100913"},"PeriodicalIF":2.2,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical analysis and in vitro anti-inflammatory, anticancer activities of Marrubium lutescens on melanoma cancer cell line and molecular docking studies 马钱子对黑色素瘤癌细胞系的植物化学分析、体外抗炎和抗癌活性以及分子对接研究

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-06-27 DOI: 10.1016/j.hermed.2024.100907

Cengiz Sarikurkcu, Sevim F. Erdoğmuş, Tuğba Yazar

Introduction

The use of plants and their derivatives in the search for new therapeutic agents is on the increase every day due to their versatile applications.

Methods

Phytochemical analysis of Marrubium lutescens extract was carried out by liquid chromatography–electrospray tandem mass spectrometry (LC–ESI–MS/MS). Cytotoxicity of plant extract was determined by MTT assay on G361 cells. Moreover, the binding energetics of the two predominant compounds, rosmarinic acid and chlorogenic acid, against the target proteins microtubule affinity-regulating kinase 4 (MARK4) and human tyrosinase-related protein 1 (TYRP1) were also determined using molecular docking to gain molecular insights into the induced anti-cancer effect in G361. TAS, Total oxidant activity, and oxidative stress index of the cells lysates were determined. Also, TNF-α, TGF-β, DEF-β2, IL-1β cytokine levels were determined.

Results

Twenty distinct phytochemicals were determined and among the identified compounds, rosmarinic acid and chlorogenic acid as major components. Rosmarinic acid and chlorogenic acid have exhibited energetically highly favourable binding with intracellular target proteins MARK4 and TYRP1, as shown by their respective binding affinity values (ΔG = −7.97 kcal/mol; ΔG = −7.38 kcal/mol, respectively), suggesting further molecular evidence for the induced anti-cancer effect observed in the G361 cell line. Also, we have evaluated the anticancer prospective of M. lutescens. Anti-inflammatory mediators and oxidative stress parameters were increased to plant extract exposed cell line.

Conclusions

Reported results show that plant extract shown anticancer activity on G361 cells. According to the docking results, rosmarinic acid and chlorogenic acid, the two predominant compounds identified in the extract, may be responsible for the anti-cancer effect through synergistic action via prominent inhibition of MARK4 and TYRP1.

由于植物及其衍生物的用途广泛，人们越来越多地使用它们来寻找新的治疗药物。提取物的植物化学分析采用液相色谱-电喷雾串联质谱法（LC-ESI-MS/MS）进行。通过 MTT 法测定了植物提取物对 G361 细胞的细胞毒性。此外，还利用分子对接法测定了两种主要化合物迷迭香酸和绿原酸与靶蛋白微管亲和性调节激酶 4（MARK4）和人酪氨酸酶相关蛋白 1（TYRP1）的结合能，从而从分子角度了解了诱导 G361 细胞抗癌的作用。还测定了细胞裂解物的 TAS、总氧化活性和氧化应激指数。此外，还测定了 TNF-α、TGF-β、DEF-β2、IL-1β 细胞因子的水平。测定了 20 种不同的植物化学物质，在已确定的化合物中，香豆酸和绿原酸是主要成分。迷迭香酸和绿原酸与细胞内靶蛋白 MARK4 和 TYRP1 的结合亲和值（Δ=-7.97 kcal/mol；Δ=-7.38 kcal/mol，分别为 7.97 kcal/mol、7.38 kcal/mol）表明，它们与细胞内靶蛋白 MARK4 和 TYRP1 的结合能量非常高，这为在 G361 细胞系中观察到的诱导抗癌效应提供了进一步的分子证据。此外，我们还评估了暴露于植物提取物的细胞系的抗炎介质和氧化应激参数的抗癌前景。报告结果表明，植物提取物对 G361 细胞具有抗癌活性。根据对接结果，提取物中的两种主要化合物迷迭香酸和绿原酸可能是通过协同作用突出抑制 MARK4 和 TYRP1 而产生抗癌效果的。

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引用次数: 0

Investigating the efficacy of Commiphora mukul drops in patients with knee osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial 膝关节骨性关节炎患者使用瞿麦滴剂的疗效调查：随机、双盲、安慰剂对照临床试验

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-06-27 DOI: 10.1016/j.hermed.2024.100909

Abolqasem Mirzaei , Zahra Jafari , Pardis Mohammadi Pour , Alireza Fazayeli , Alireza Soltanian , Mohammad H. Farzaei

Introduction

Knee osteoarthritis is the common joint disease and one of the major causes of pain and disability in the world. Regarding the people tendency to traditional medicine the present study was designed to survey the activity of Commiphora mukul (C. mukul) drops on knee osteoarthritis for the first time.

Methods

The present study was performed as a randomized, double-blind placebo-controlled trial with 70 patients with moderate knee osteoarthritis, which divided into two groups, drug recipients and placebo. Twenty drops were administered to the placebo group and the control group was administered 20 drops of drug twice a day for 2 months. The pain, function and clinical health scores of both groups were measured at the beginning and end of the study with Visual Analogue Scale and knee injury and osteoarthritis outcome score evaluation scales.

Results

The intervention and control groups were similar in terms of age, gender, pain score and knee function before the intervention. Pain intensity in right and left legs was decreased and exhibited statistically significant differences before and after the intervention in both the intervention group (P < 0.001) and the control group (P < 0.01). Five indices of discomfort and dryness, pain, activity and daily activities, exercise and recreation and quality of life in the intervention group, improved (P < 0.001) though in control group the difference between indices were not significant except exercise and recreation.

Discussion/Conclusions

The consumption of C. mukul extract for 2 months was effective in relieving the symptoms of the knee osteoarthritis in patients and improve the quality of life.

导言：膝关节骨关节炎是一种常见的关节疾病，也是世界上导致疼痛和残疾的主要原因之一。本研究采用随机、双盲安慰剂对照试验的方法，将 70 名中度膝骨关节炎患者分为两组，即接受药物治疗组和安慰剂治疗组。安慰剂组滴入 20 滴药物，对照组滴入 20 滴药物，每天两次，为期 2 个月。结果干预组和对照组在干预前的年龄、性别、疼痛评分和膝关节功能方面相似。干预组（P< 0.001）和对照组（P< 0.01）左右腿疼痛强度均有所下降，干预前后差异有统计学意义。干预组的不适和干燥、疼痛、活动和日常活动、运动和娱乐以及生活质量五项指标均有所改善（P <0.001），而对照组除运动和娱乐外，其他指标差异不显著。

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引用次数: 0

Ethnopharmacological Investigation of Plants Used in the Treatment of Breast Cancer in Northern Cameroon 对喀麦隆北部用于治疗乳腺癌的植物进行民族药理学调查

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-06-26 DOI: 10.1016/j.hermed.2024.100906

H. Mohamadou , S.R. Tagne , L.L. LIENOU , P.H. Kada , E.E.L. Embolo , K.G. Nganwa , O.J.L. Essame , D.P.M. Jazet

Introduction

Therapeutic activities of medicinal plants are due to the different secondary metabolites, which are stored in their organs and constitute a large reservoir. These medicinal plants could allow the development of new biomolecules, which would constitute an alternative against highly toxic breast cancer chemotherapy. The present study identifies the medicinal plants used by the traditional medicine practitioners of the northern region of Cameroon in the treatment of this pathology.

Methods

A semistructured questionnaire was used to collect sociodemographic information from participants as well as ethnobotanical and ethnopharmacological data of the different treatments. The approach used to conduct the survey was an interview with the traditional medicine practitioners of the region using the local language.

Results

As a result, 131 traditional healers were interviewed; they provided 50 therapeutic recipes made from 37 plant species belonging to 21 families. The recipes presented are mainly formulated from a single plant (74%) while among the combinations, associating two plants was predominant (18%). The bark was the most used organ (46%) while the most used preparation methods were decoction (52%) and maceration (36%). Treatments were mainly administered orally for an unlimited duration (until recovery). The plants listed were found to be rich in secondary metabolites such as alkaloids, flavonoids, or tannins that revealed anticancer activities through literature.

Conclusions

The results of the present work constitute a strong basis for the search of new anticancer chemotherapeutic agents that would be more available and less invasive.

导言药用植物的治疗活性归功于其器官中储存的不同次生代谢物，这些次生代谢物构成了一个巨大的宝库。这些药用植物可以开发出新的生物分子，成为乳腺癌高毒性化疗的替代品。本研究确定了喀麦隆北部地区传统医学从业者在治疗这种病症时使用的药用植物。方法采用半结构式问卷收集参与者的社会人口学信息以及不同治疗方法的民族植物学和民族药理学数据。调查采用的方法是用当地语言对该地区的传统医师进行访谈。结果共访谈了 131 位传统医师，他们提供了由 21 个科 37 种植物制成的 50 种治疗配方。所提供的食谱主要由单一植物配制而成（74%），而在组合食谱中，主要由两种植物配制而成（18%）。树皮是最常用的器官（46%），而最常用的配制方法是煎煮（52%）和浸泡（36%）。治疗方法主要是口服，持续时间不受限制（直至康复）。通过文献发现，所列植物富含生物碱、黄酮类或单宁酸等次生代谢物，具有抗癌活性。

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引用次数: 0

Medicinal Plants Used for Antenatal and Postnatal Care in Ondo Town, Nigeria 尼日利亚翁多镇用于产前和产后护理的药用植物

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-06-25 DOI: 10.1016/j.hermed.2024.100908

O.O. Ovuakporie-Uvo , O.A. Akinnaanu , S.O. Awosika , M. Idu

Introduction

Plants used in traditional medicine by different ethnic groups define the field of ethnomedicine, a subfield of ethnobotany. A preliminary survey revealed that Ondo women still engage in the services of traditional birth attendants till the present day.

Methods

Structured questionnaires and personal interviews were used to obtain information from 124 respondents, consisting of males and females.

Results

The major plant part used were leaves with a frequency of 35%. Some of the plants reported were solely administered, while others were administered in combination with other plants. The traditional solvents commonly used were water and coconut water. The main methods of herbal preparation were decoction and soups. The methods of administration ranged from half a cup or 2 taken 2–3 times daily.

Conclusions

This study has increased our knowledge of Ondo womens’ antenatal and postnatal care practices. Proper documentation of these traditional claims pending scientific validation is necessarily recommended.

导言：不同民族在传统医学中使用的植物决定了民族医学领域是民族植物学的一个分支领域。一项初步调查显示，翁多妇女至今仍在使用传统助产士的服务。方法采用结构化问卷和个人访谈的方式从 124 名受访者（包括男性和女性）那里获得信息。所报告的植物中，有些是单独使用，有些则是与其他植物混合使用。常用的传统溶剂是水和椰子汁。草药制剂的主要方法是煎煮和煲汤。服用方法从半杯到两杯不等，每天服用 2-3 次。建议在科学验证之前对这些传统说法进行适当记录。

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引用次数: 0