Journal of Herbal Medicine最新文献_第8页

Antibacterial and anti-inflammatory effects of Thunbergia laurifolia Lindl., Moringa oleifera Lam. and Phyllanthus amarus Schumach. & Thonn. extracts 菝葜的抗菌和抗炎作用。辣木；和Phyllanthus amarus Schumach。& Thonn。提取

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-03-12 DOI: 10.1016/j.hermed.2025.101007

Atittaya Rocejanasaroj, Potjaman Pumeesat, Julaluk Noiphung, Piya Wongyanin

Introduction

There is increasing evidence suggesting that chronic inflammation in the gastrointestinal tract may be caused by pathogenic infections, leading to destructive inflammatory conditions such as periodontal disease. This study aimed to investigate the antimicrobial and anti-inflammatory properties of ethanolic extracts from Thunbergia laurifolia Lindl. (TLE), Phyllanthus amarus Schumach. & Thonn. (PAE), and Moringa oleifera Lam. (MOE).

Methods

The antimicrobial activity of crude ethanol extracts was assessed using disk diffusion and broth dilution methods against Bacillus cereus, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Vibrio cholerae. The anti-inflammatory properties of herbal extracts by measuring the level of interleukin-6 (IL-6), tumour necrosis factor-alpha, and monocyte chemoattractant protein-1 (MCP-1) secretion in THP-1 macrophage cells over 24 hours, both in the absence and presence of lipopolysaccharide.

Results

All herbal extracts exhibited antibacterial activity against B. cereus, S. aureus, and V. cholerae, but were ineffective against E. coli and P. aeruginosa. The inhibitory effects were dose-dependent, with minimum inhibitory concentration (MIC) values ranging from 625 to 5 000 µg/ml and minimum bactericidal concentration values ranging from 625 to 10 000 µg/ml. MOE showed the highest antibacterial activity against V. cholerae (MIC = 625 µg/ml), while PAE exhibited the most inhibitory effects against B. cereus (MIC = 625 µg/ml). Additionally, PAE and TLE as low as 200 µg/ml completely inhibit IL-6 secretion and reduce Tumor Necrosis Factor-alpha (TNF-α) and MCP-1 secretion in a concentration-dependent manner.

Conclusions

All three herbal extracts have the potential to attenuate the secretion of inflammatory cytokines and exhibit antibacterial activity that may prevent foodborne infections.

导言：越来越多的证据表明，胃肠道的慢性炎症可能是由病原体感染引起的，从而导致牙周病等破坏性炎症。本研究旨在探讨月桂树（Thunbergia laurifolia Lindl.，TLE）、苋菜（Phyllanthus amarus Schumach. & Thonn.，PAE）和油杉（Moringa oleifera Lam.，MOE）乙醇提取物的抗菌和消炎特性。(方法采用磁盘扩散法和肉汤稀释法评估粗乙醇提取物对蜡样芽孢杆菌、金黄色葡萄球菌、大肠杆菌、绿脓杆菌和霍乱弧菌的抗菌活性。在没有脂多糖和有脂多糖的情况下，通过测量 24 小时内 THP-1 巨噬细胞中白细胞介素-6（IL-6）、肿瘤坏死因子-α 和单核细胞趋化蛋白-1（MCP-1）的分泌水平，检测草药提取物的抗炎特性。结果所有草药提取物都对蜡样芽孢杆菌、金黄色葡萄球菌和霍乱弧菌具有抗菌活性，但对大肠杆菌和绿脓杆菌无效。抑菌效果与剂量有关，最低抑菌浓度（MIC）值为 625 至 5 000 微克/毫升，最低杀菌浓度值为 625 至 10 000 微克/毫升。MOE 对霍乱弧菌的抗菌活性最高（MIC = 625 µg/ml），而 PAE 对蜡样芽孢杆菌的抑制作用最强（MIC = 625 µg/ml）。此外，低至 200 µg/ml 的 PAE 和 TLE 可完全抑制 IL-6 的分泌，并以浓度依赖的方式减少肿瘤坏死因子-α（TNF-α）和 MCP-1 的分泌。

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引用次数: 0

Ethnomedicinal survey of antidiabetic plants used by six indigenous communities in Sarawak, Borneo 婆罗洲沙捞越六个土著社区使用的抗糖尿病植物的民族医学调查

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-03-25 DOI: 10.1016/j.hermed.2025.101011

Keeren Sundara Rajoo , Philip Lepun , Beatrice Lyeja Anak Kayok , Nurul Azwany Umayrah , Nazariena Abdullah

Introduction

Sarawak, located in one of the planet's most ecologically diverse regions, hosts over 30 distinct sub-ethnic groups, each with its own set of cultural, linguistic, and lifestyle distinctions. This has fostered the development of numerous, unique ethnobotanical traditions. Thus, this study aimed to document the antidiabetic ethnomedicinal knowledge of six indigenous communities and to examine how their cultural practices and beliefs influenced their respective approaches to managing diabetes.

Methods

Fieldwork was carried out between 2021 and 2024, engaging 231 herbal medicine practitioners from six Sarawak indigenous groups: Kenyah (n = 24), Melanau Igan (n = 71), Kayan (n = 30), Iban (n = 81), Punan (n = 13), and Baketan (n = 12). Ethnobotanical information was gathered using face-to-face interviews through both unstructured and semi-structured methods.

Results

The study documented 34 plant species utilised for diabetes treatment across five of the six communities, with 127 total use-reports. Annona muricata emerged as the most frequently cited species, with 22 use-reports spanning four communities, followed by Orthosiphon aristatus with 14 use-reports from two communities. Substantial differences were noted in traditional knowledge transmission, with rates ranging from 25% in the Kenyah to 91.5% in the Melanau Igan. Plant knowledge similarity between communities ranged from 0% to 35.29%, the highest similarity observed between the Kenyah and Iban.

Discussion/Conclusions

This study documents the distribution and transmission of antidiabetic plant knowledge within Sarawak's indigenous populations, with significant variations in species utilisation and knowledge preservation across communities. The quantified differences in knowledge transmission rates and practitioner expertise indicate varying levels of traditional knowledge preservation among the studied groups.

沙捞越位于地球上生态最多样化的地区之一，拥有30多个不同的亚民族，每个民族都有自己的文化、语言和生活方式的特点。这促进了许多独特的民族植物学传统的发展。因此，本研究旨在记录六个土著社区的抗糖尿病民族医学知识，并研究他们的文化习俗和信仰如何影响他们各自管理糖尿病的方法。方法在2021年至2024年期间，对来自沙捞越6个土著群体的231名草药从业者进行了实地调查：肯雅（n = 24）、Melanau Igan （n = 71）、Kayan （n = 30）、Iban （n = 81）、Punan （n = 13）和Baketan （n = 12）。民族植物学信息收集采用面对面访谈，通过非结构化和半结构化的方法。该研究记录了6个社区中5个社区34种用于糖尿病治疗的植物物种，总共有127份使用报告。凤仙花（Annona muricata）是最常被引用的物种，在4个群落中有22份利用报告，其次是两个群落的直虹吸（Orthosiphon aristatus），有14份利用报告。在传统知识传播方面存在显著差异，其传输率从肯亚族的25%到梅拉瑙伊根族的91.5%不等。群落间植物知识相似性为0% ~ 35.29%，其中肯雅族和伊班族相似性最高。本研究记录了沙捞越土著居民抗糖尿病植物知识的分布和传播，在物种利用和知识保存方面存在显著差异。知识传输率和从业者专业知识的量化差异表明，在研究群体中，传统知识的保存水平存在差异。

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引用次数: 0

An ethnopharmacological study of medicinal plants used for the treatment of urinary illness in the El-Oued region (Algerian Sahara) 阿尔及利亚撒哈拉El-Oued地区用于治疗泌尿系统疾病的药用植物的民族药理学研究

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-05-12 DOI: 10.1016/j.hermed.2025.101026

Djahra Ali Boutlelis , Benkaddour Mounia , Chabani Hadjer , Hamed Bahia , Benkherara Salah , Benine Chaima , Laib Ibtissam

The goal of our study is shown by the ethnobotanical investigation of traditional medicinal plants used by people in El-Oued State in southeast Algeria to treat urinary illness. The information was gathered via in-person interviews and written questionnaires. A total of 117 participants were interviewed, with the majority of them aged 50. The study of plants that can be used to treat urinary diseases has led to the discovery of 37 species in 23 families and different genera, including 49% of medicinal plants found in cultivated plants. Around 56% of plants were employed largely in their dried form for remedy preparation. The infusion method was the most widely used preparation method, and 70% of the participants cited Petroselinum crispum (Mill.) Fuss, Parietaria officinalis L., and Apium graveolens L., as sources of urinary illnesses treatment. According to the findings of this study, a significant number of individuals in the research area continue to treat urinary problems using herbal treatments. On the other hand, the current study offers crucial ethnobotanical data on medicinal plants that will serve as a starting point for future thorough research. This data will be provided by the present study.

我们的研究目标是通过对阿尔及利亚东南部El-Oued州人们用于治疗泌尿系统疾病的传统药用植物的民族植物学调查来表明的。这些信息是通过面对面访谈和书面问卷收集的。共有117名参与者接受了采访，其中大多数年龄在50岁。对可用于治疗泌尿系统疾病的植物的研究，已发现23科不同属37种，其中在栽培植物中发现的药用植物占49%。大约56%的植物主要以其干燥形式用于药物制备。输液法是最广泛使用的制备方法，70%的参与者引用了Petroselinum crispum （Mill.）。作为泌尿系统疾病治疗的来源，包括：Parietaria officinalis L.和Apium graveolens L.。根据这项研究的结果，在研究领域有相当多的人继续使用草药治疗泌尿系统问题。另一方面，目前的研究为药用植物提供了重要的民族植物学数据，将作为未来深入研究的起点。本研究将提供这些数据。

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引用次数: 0

Effects of topical herbal medicine on rosacea: a systematic review and meta-analysis 局部草药对酒渣鼻的影响：系统回顾和荟萃分析

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-04-30 DOI: 10.1016/j.hermed.2025.101022

Huan-Hsuan Hsu , Ya-Ching Chang , Zi-Yu Chang , Jian-An Liao

Introduction

Rosacea is a chronic inflammatory skin condition characterised by facial erythema, papules, pustules, and telangiectasia. Traditional treatments often associated with adverse effects and high recurrence rates. This review evaluates the effectiveness and safety of topical herbal medicines for rosacea.

Methods

We conducted a systematic review of randomised controlled trials (RCTs) from various databases, including PubMed, Embase, MEDLINE, Cochrane Library, Chinese Electronic Periodical Services (CEPS), China National Knowledge Infrastructure (CNKI), and http://ClinicalTrials.gov databases from the inception of the source to September 1, 2024. Studies were selected based on inclusion and exclusion criteria, and data regarding study characteristics, interventions, outcomes, and adverse events were extracted. The risk of bias was assessed using the Cochrane risk of bias tool. Moreover, statistical analyses were performed using Review Manager software. The protocol was registered on PROSPERO under the registration number CRD42022383985.

Results

In total, 10 RCTs involving 833 participants were included. The meta-analysis revealed that topical herbal medicines exhibited significantly greater efficacy in treating skin lesions (RR = 1.21; 95% CI = 1.09–1.34) and resulted in a significantly improved Investigator Global Assessment of Rosacea Severity Score (IGA-RSS) (MD = −0.40; 95% CI = −0.50 to −0.30) than control treatments. Adverse events were reported in eight studies; however, no significant difference was noted between the intervention and control groups. Sensitivity analysis reduced heterogeneity, further confirming these findings.

Conclusions

Topical herbal medicines appear to be effective and safe for treating rosacea; they also exhibit fewer adverse effects than conventional treatments.

酒渣鼻是一种慢性炎症性皮肤病，以面部红斑、丘疹、脓疱和毛细血管扩张为特征。传统的治疗方法往往伴随着不良反应和高复发率。本综述评价了局部草药治疗酒渣鼻的有效性和安全性。方法我们对来自PubMed、Embase、MEDLINE、Cochrane图书馆、中国电子期刊服务中心（CEPS）、中国知网（CNKI）和http://ClinicalTrials.gov等数据库的随机对照试验（RCTs）进行系统评价，时间从文献开始至2024年9月1日。根据纳入和排除标准选择研究，并提取有关研究特征、干预措施、结果和不良事件的数据。使用Cochrane偏倚风险工具评估偏倚风险。此外，使用Review Manager软件进行统计分析。该协议在PROSPERO上注册，注册号为CRD42022383985。结果共纳入10项随机对照试验，纳入受试者833人。荟萃分析显示，外用草药治疗皮肤病变的疗效显著提高(RR = 1.21；95% CI = 1.09-1.34)，结果显著改善了研究者酒渣鼻严重程度评分（IGA-RSS） (MD = - 0.40；95% CI = - 0.50 ~ - 0.30)。8项研究报告了不良事件；然而，干预组和对照组之间没有显著差异。敏感性分析降低了异质性，进一步证实了这些发现。结论中药治疗酒渣鼻安全有效；与传统疗法相比，它们也表现出更少的副作用。

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引用次数: 0

Wound healing potential of Labisia pumila extracts and relationship with its phytochemical contents through in silico assessment 阴唇提取物的创面愈合潜力及其与植物化学成分的关系

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-05-05 DOI: 10.1016/j.hermed.2025.101024

Atiqah Azam , Shihab Uddin Ahmad , Mohiuddin Ahmed Bhuiyan , Ajoy Kumer , Sanjit Dash , Shiplu Roy Chowdhury , Ahmad Nazrun Shuid , Isa Naina Mohamed

Introduction

Labisia pumila (LP) has traditionally been used for women's postnatal recovery, with research highlighting its antioxidant, anti-inflammatory, antimicrobial, and phytoestrogen properties essential for wound healing. This study explores its wound-healing potential through in vitro and in silico models.

Methods

The study focused on the proliferation and migration activities of human primary skin fibroblasts and keratinocytes treated with two common LP varieties found in Malaysia: var. pumila and var. alata. leaf and root aqueous extracts.

Results

Results showed that root extracts of both LP species were toxic to skin cells at low concentrations compared to leaf extracts. Optimal concentrations of LP leaf extracts (1.5 µg/ml for fibroblasts and 3.1 µg/ml for keratinocytes) significantly increased (P < 0.05) the proliferation of fibroblasts (194000 ± 3623 cells/cm²) and keratinocytes (275578 ± 14959 cells/cm²) compared to untreated controls. Additionally, both LP leaf extracts promoted higher healing rates (P < 0.05) in fibroblasts (14791.5 ± 1615.6 μm²/h) and keratinocytes (20438 ± 2206 μm²/h) compared to the control group. Furthermore, a docking study was conducted to assess the affinity of major phytoconstituents for binding to glycogen synthase kinase 3-β (GSK3-β), a protein involved in wound healing. Ellagic acid derivative showed the highest binding affinity (-12 kcal/mol)) against GSK3-β.

Conclusion

In conclusion, both LP var. alata and var. pumila leaf extracts demonstrated the ability to enhance the proliferation and migration of fibroblasts and keratinocytes, suggesting their potential for promoting wound healing.

阴唇（LP）传统上用于女性产后恢复，研究强调其抗氧化，抗炎，抗菌和植物雌激素特性对伤口愈合至关重要。本研究通过体外和硅模型探索其伤口愈合潜力。方法研究马来西亚常见的两种LP品种var. pumila和var. alata对人原代皮肤成纤维细胞和角质形成细胞的增殖和迁移活性。叶和根的水提取物。结果两种植物的根提取物在低浓度下均比叶提取物对皮肤细胞有毒性。LP叶提取物的最佳浓度（成纤维细胞为1.5µg/ml，角质形成细胞为3.1µg/ml）显著增加(P <；0.05)成纤维细胞（194000±3623个细胞/cm2）和角质形成细胞（275578±14959个细胞/cm2）的增殖。此外，两种LP叶提取物都促进了更高的愈合率(P <；0.05)，成纤维细胞（14791.5±1615.6 μm2/h）和角质形成细胞（20438±2206 μm2/h）与对照组比较。此外，一项对接研究评估了主要植物成分与糖原合成酶激酶3-β (GSK3-β)结合的亲和力，GSK3-β是一种参与伤口愈合的蛋白质。鞣花酸衍生物对GSK3-β的结合亲和力最高（-12 kcal/mol）。结论紫丁香叶提取物和紫丁香叶提取物均能促进成纤维细胞和角质形成细胞的增殖和迁移，具有促进创面愈合的作用。

{"title":"Wound healing potential of Labisia pumila extracts and relationship with its phytochemical contents through in silico assessment","authors":"Atiqah Azam , Shihab Uddin Ahmad , Mohiuddin Ahmed Bhuiyan , Ajoy Kumer , Sanjit Dash , Shiplu Roy Chowdhury , Ahmad Nazrun Shuid , Isa Naina Mohamed","doi":"10.1016/j.hermed.2025.101024","DOIUrl":"10.1016/j.hermed.2025.101024","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Labisia pumila (LP)</em> has traditionally been used for women's postnatal recovery, with research highlighting its antioxidant, anti-inflammatory, antimicrobial, and phytoestrogen properties essential for wound healing. This study explores its wound-healing potential through <em>in vitro</em> and <em>in silico</em> models.</div></div><div><h3>Methods</h3><div>The study focused on the proliferation and migration activities of human primary skin fibroblasts and keratinocytes treated with two common LP varieties found in Malaysia: <em>var. pumila and var. alata</em>. leaf and root aqueous extracts.</div></div><div><h3>Results</h3><div>Results showed that root extracts of both LP species were toxic to skin cells at low concentrations compared to leaf extracts. Optimal concentrations of LP leaf extracts (1.5 µg/ml for fibroblasts and 3.1 µg/ml for keratinocytes) significantly increased (<em>P</em> < 0.05) the proliferation of fibroblasts (194000 ± 3623 cells/cm<sup>2</sup>) and keratinocytes (275578 ± 14959 cells/cm<sup>2</sup>) compared to untreated controls. Additionally, both LP leaf extracts promoted higher healing rates (<em>P</em> < 0.05) in fibroblasts (14791.5 ± 1615.6 μm<sup>2</sup>/h) and keratinocytes (20438 ± 2206 μm<sup>2</sup>/h) compared to the control group. Furthermore, a docking study was conducted to assess the affinity of major phytoconstituents for binding to glycogen synthase kinase 3-β (GSK3-<em>β</em>), a protein involved in wound healing. Ellagic acid derivative showed the highest binding affinity (-12 kcal/mol)) against GSK3-<em>β</em>.</div></div><div><h3>Conclusion</h3><div>In conclusion, both LP <em>var. alata and var. pumila</em> leaf extracts demonstrated the ability to enhance the proliferation and migration of fibroblasts and keratinocytes, suggesting their potential for promoting wound healing.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101024"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of Pueraria lobata radix-containing traditional Chinese medicine in the treatment of essential hypertension: a systematic review 葛根中药治疗原发性高血压的疗效和安全性：系统评价

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1016/j.hermed.2025.101010

Xiangmin Deng , Qiuyun Xue , Xianjie Feng , Haoyu Wang , Ping Luo , Yaqi Tian , Rui Zhang , Gaochuan Zhang , Dongmei Yan , Xu Zhou

Introduction

This study aims to systematically review the efficacy and safety of Pueraria lobata radix (Chinese name: Ge Gen) prescriptions (GGPs) of traditional Chinese medicine in treating hypertension.

Methods

We searched seven databases for randomised controlled trials (RCTs) comparing GGPs plus antihypertensive drugs versus antihypertensive drugs alone for essential hypertension. Primary outcomes were changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP), while secondary outcomes included 24hSBP, 24hDBP, responses to antihypertensive treatment, control of hypertensive symptoms, blood glucose and lipid indicators, and incidence of adverse events.

Results

Thirty-one RCTs involving 2 501 patients were included. Compared with antihypertensive drugs alone, GGP adjuvant therapy significantly reduced SBP (mmHg) (mean difference [MD] −10.70, 95% confidence interval [CI] −12.75 to −8.65), DBP (MD −6.78, 95% CI −8.51 to −5.05), and 24hSBP (MD −7.13, 95% CI −10.78 to −3.47), increased the response to antihypertensive treatment (risk ratio 1.21, 95% CI 1.13–1.30) and hypertensive symptom control, and improved levels of total and low-density lipoprotein cholesterol, triglycerides, and blood glucose indicators. However, GGPs had no significant impact on high-density lipoprotein cholesterol (HDL-C) or 24hDBP, although the trial sequential analysis suggested false negatives for these outcomes.

Conclusion

GGPs, when used as complementary therapy, may improve various parameters related to blood pressure, blood lipids, and blood glucose in patients with essential hypertension and show good safety. However, the impact of GGPs on 24hDBP, hypertensive symptoms, and HDL-C remains uncertain due to the limited quality of evidence.

引言本研究旨在系统回顾中药葛根汤治疗高血压的疗效和安全性。方法我们检索了七个数据库中的随机对照试验（RCT），比较了葛根汤加降压药与单用降压药治疗原发性高血压的效果。主要结果是收缩压（SBP）和舒张压（DBP）的变化，次要结果包括 24 小时收缩压（SBP）、24 小时舒张压（DBP）、对降压治疗的反应、高血压症状的控制、血糖和血脂指标以及不良事件的发生率。与单独使用降压药相比，GGP 辅助治疗可显著降低 SBP（mmHg）（平均差 [MD] -10.70，95% 置信区间 [CI] -12.75 至 -8.65）、DBP（MD -6.78，95% CI -8.51 至 -5.05）和 24hSBP （MD -7.13，95% CI -10.78至-3.47），增加了对降压治疗的反应（风险比为1.21，95% CI为1.13-1.30）和高血压症状的控制，并改善了总胆固醇和低密度脂蛋白胆固醇、甘油三酯和血糖指标的水平。然而，GGPs 对高密度脂蛋白胆固醇（HDL-C）或 24hDBP 没有显著影响，尽管试验序列分析表明这些结果存在假阴性。然而，由于证据质量有限，GGPs 对 24hDBP、高血压症状和高密度脂蛋白胆固醇的影响仍不确定。

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引用次数: 0

Aloe ferox, Agathosma betulina, and Bulbine frutescens Extracts Show Antifungal Activity at Concentrations Favourable to the Proliferation of Epidermal Cells 芦荟、白桦松茸和球根草提取物在有利于表皮细胞增殖的浓度下显示出抗真菌活性

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-04-19 DOI: 10.1016/j.hermed.2025.101019

Banele Ndlovu , Jeremy Klaasen , Pedro Abrantes , Charlene Africa , Farzana Fisher (née Rahiman)

Introduction

The increasing prevalence of antifungal resistance presents an enormous challenge to healthcare professionals. The adverse effects and resistance of current antifungal drugs have prompted the need for alternate antifungal therapy in the form of natural products. Although anecdotal reports have suggested that Aloe ferox, Agathosma betulina, and Bulbine frutescens have been used to successfully treat fungal skin infections, little scientific evidence is available to validate these claims. Therefore, this study aimed to determine whether the concentrations of A ferox, A betulina, and B frutescens hydroethanolic extracts showing antifungal activity against skin-related Candida species are cytotoxic to normal human epidermal cells.

Methods

Crystal violet and lactate dehydrogenase assays were employed to determine cell viability and cytotoxicity on the human epidermal cells. Broth microdilutions were performed to evaluate the susceptibility of Candida species to plant extracts.

Results

Candida spp. inhibition was observed at a concentration of 200 µg/ml, while optimum extract concentrations for cell proliferation ranged between 200 and 400 µg/ml for B frutescens and 200 µg/ml for A ferox and A betulina. This suggests that these plants could prove to be effective as antifungal agents at a dosage of 200 µg/ml while still supporting the growth of epidermal cells at the same concentration, which is an important process in maintaining healthy skin.

Conclusions

These findings from this study lay a foundation for further studies confirming the applicability of these medicinal plants as safe alternative antifungal treatments that promote skin cell proliferation, regeneration, and enhance tissue repair.

越来越普遍的抗真菌药物耐药性给医护人员带来了巨大的挑战。目前抗真菌药物的不良反应和耐药性促使人们需要以天然产物的形式替代抗真菌治疗。尽管坊间报道表明，芦荟、白桦木条和球果已被用于成功治疗真菌皮肤感染，但几乎没有科学证据可以证实这些说法。因此，本研究旨在确定对皮肤相关念珠菌具有抗真菌活性的白桦、白桦和果蔓氢乙醇提取物的浓度是否对正常人表皮细胞具有细胞毒性。方法采用结晶紫法和乳酸脱氢酶法测定人表皮细胞的细胞活力和细胞毒性。采用肉汤微稀释法评价念珠菌对植物提取物的敏感性。结果200 µg/ml对scandida spp有抑制作用，而对B frutescens、a ferox和a betulina细胞增殖的最佳提取浓度为200 ~ 400 µg/ml。这表明，在200 µg/ml的剂量下，这些植物可以被证明是有效的抗真菌剂，同时在相同的浓度下仍然支持表皮细胞的生长，这是维持皮肤健康的重要过程。结论本研究结果为进一步研究证实这些药用植物作为促进皮肤细胞增殖、再生和组织修复的安全替代抗真菌药物的适用性奠定了基础。

{"title":"Aloe ferox, Agathosma betulina, and Bulbine frutescens Extracts Show Antifungal Activity at Concentrations Favourable to the Proliferation of Epidermal Cells","authors":"Banele Ndlovu , Jeremy Klaasen , Pedro Abrantes , Charlene Africa , Farzana Fisher (née Rahiman)","doi":"10.1016/j.hermed.2025.101019","DOIUrl":"10.1016/j.hermed.2025.101019","url":null,"abstract":"<div><h3>Introduction</h3><div>The increasing prevalence of antifungal resistance presents an enormous challenge to healthcare professionals. The adverse effects and resistance of current antifungal drugs have prompted the need for alternate antifungal therapy in the form of natural products. Although anecdotal reports have suggested that <em>Aloe ferox</em>, <em>Agathosma betulina,</em> and <em>Bulbine frutescens</em> have been used to successfully treat fungal skin infections, little scientific evidence is available to validate these claims. Therefore, this study aimed to determine whether the concentrations of <em>A ferox</em>, <em>A betulina,</em> and <em>B frutescens</em> hydroethanolic extracts showing antifungal activity against skin-related <em>Candida</em> species are cytotoxic to normal human epidermal cells.</div></div><div><h3>Methods</h3><div>Crystal violet and lactate dehydrogenase assays were employed to determine cell viability and cytotoxicity on the human epidermal cells. Broth microdilutions were performed to evaluate the susceptibility of <em>Candida</em> species to plant extracts.</div></div><div><h3>Results</h3><div><em>Candida</em> spp. inhibition was observed at a concentration of 200 µg/ml, while optimum extract concentrations for cell proliferation ranged between 200 and 400 µg/ml for <em>B frutescens</em> and 200 µg/ml for <em>A ferox</em> and <em>A betulina</em>. This suggests that these plants could prove to be effective as antifungal agents at a dosage of 200 µg/ml while still supporting the growth of epidermal cells at the same concentration, which is an important process in maintaining healthy skin.</div></div><div><h3>Conclusions</h3><div>These findings from this study lay a foundation for further studies confirming the applicability of these medicinal plants as safe alternative antifungal treatments that promote skin cell proliferation, regeneration, and enhance tissue repair.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101019"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Qualitative Study on Practitioners Participating in the COVID-19 Telemedicine Centre of Korean Medicine 韩国医学COVID-19远程医疗中心从业人员参与的定性研究

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-04-20 DOI: 10.1016/j.hermed.2025.101017

Hye-Young Jang , Seung-Yeon Jeong , Eun-Kyoung Lee , Song-Yi Kim

Introduction

This qualitative study explored the integration of Korean medicine, particularly herbal medicine, in non-face-to-face care during the rapid increase in coronavirus disease 2019 patients in South Korea. This initiative was implemented voluntarily without governmental support.

Methods

We conducted in-depth interviews with twelve Korean medicine doctors from the Korean Medicine Telemedicine Centres in Daegu and Seoul, analysing the data using qualitative content analysis.

Results

The findings were categorised into four themes: (1) establishment of the Korean Medicine Telemedicine Centre amidst the conflict between Korean and Western medicine and a strong internal motivation; (2) patients as viewed by Korean medicine doctors and what patients want from Korean medicine treatment; (3) hope and the value of Korean medicine found again through new experience; (4) changes to be prepared for future Korean medicine to take a step forward.

Conclusions

This study highlights the potential of Korean medicine telemedicine as a viable healthcare model beyond the coronavirus disease 2019 pandemic, addressing both its opportunities and challenges in infectious disease management. To ensure its long-term integration, future efforts should focus on developing standardised treatment protocols, advancing telemedicine technologies, and fostering collaboration between Korean medicine and Western medicine within a more inclusive healthcare system.

本定性研究探讨了在韩国2019年冠状病毒病患者快速增加期间，韩国医学，特别是草药在非面对面护理中的整合。这项倡议是在没有政府支持的情况下自愿执行的。方法对大邱、首尔两市韩医远程医疗中心的12名韩医医生进行深度访谈，采用定性内容分析法对数据进行分析。结果研究结果分为4个主题：(1)韩医远程医疗中心的建立是在韩西医冲突和强烈的内在动机下进行的；(2)韩医医生对患者的看法以及患者对韩医治疗的需求；(3)通过新的体验重新发现韩国医学的希望和价值；(4)为未来韩国医学的发展做好准备的变化。本研究强调了韩国医疗远程医疗作为一种可行的医疗模式在2019冠状病毒病大流行之后的潜力，解决了其在传染病管理方面的机遇和挑战。为了确保其长期整合，未来的努力应该集中在制定标准化的治疗方案，推进远程医疗技术，以及在更具包容性的医疗体系中促进韩国医学和西方医学之间的合作。

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引用次数: 0

An Ethnobotanical Survey of Medicinal Plants Used to Manage Diabetes in Bulawayo, Zimbabwe 在津巴布韦布拉瓦约用于治疗糖尿病的药用植物的民族植物学调查

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-04-21 DOI: 10.1016/j.hermed.2025.101018

Moreblessing Dube , Stephen Nyoni , Kimberly Chido Cheryl Konono , Zedias Chikwambi

Introduction

Diabetes mellitus is a metabolic disorder associated with hyperglycaemia resulting from defects in insulin secretion reaction. Medicinal plants are becoming a strong potential alternative to synthetic medication, diet, and exercise due to their reported fewer side effects, affordability, and availability. The study gathers traditional information about medicinal plants used for diabetes in Bulawayo province.

Methods

Eighty traditional medical practitioners and twenty diabetes patients were recruited for the survey. Interviews, observations, and field surveys were used to collect data.

Results

Ninety-seven plants were mentioned (40 cultivated plants and 57 indigenous plants). Only 49 plant species belonging to 28 families were identified at the National Herbarium, with Fabaceae recorded the highest(22%). Zanthoxylum capense (Thunb.) Harv., Opuntia ficus-indica (L.) Mill and Monotes engleri Gilg. were frequently used for diabetes management. In addition to having high ethnobotanical indices values, the identified plants were reported to be antidiabetic in the literature reviewed. Only five species were not reported. Tamarindus indica L. was cited 15 times, followed by Opuntia ficus-indica (L.) Mill. (14 times) and Adansonia digitata L. (10 times). Herbal formulations were mainly infusion of fresh/dried parts(36%) or powder(13%) followed by decoction(12%) and cooking(6%), and were all administered orally. The commonly used plant parts were roots(32%), leaves(11, 5%), and fruits(7%).

Discussion/Conclusions

Various diabetic effects reported by the participants were affirmed by the reviewed literature. The study recommends the use of ethnomedicinal plants as both alternative and complementary diabetic medicine.

糖尿病是一种由胰岛素分泌反应缺陷引起的伴有高血糖的代谢紊乱。药用植物正成为合成药物、饮食和运动的强大潜在替代品，因为据报道，它们的副作用更小，价格低廉，而且容易获得。该研究收集了布拉瓦约省用于治疗糖尿病的药用植物的传统信息。方法对80名中医和20名糖尿病患者进行调查。采用访谈、观察和实地调查等方法收集数据。结果共发现植物97种，其中栽培植物40种，乡土植物57种。国家标本室共鉴定植物28科49种，以豆科最多（22%）。花椒（花椒）哈里。，无花果树（L.）米尔和莫奈斯·英格利·吉尔。经常用于糖尿病的治疗。除了具有较高的民族植物学指标值外，所鉴定的植物在文献中也有报道具有抗糖尿病作用。仅有5种未被报道。柽柳（Tamarindus indica L.）被引15次，其次是无花果（Opuntia ficus-indica L.）。轧机。（14次）和Adansonia digitata L.（10次）。中药制剂以鲜/干浸剂（36%）或粉剂（13%）为主，其次为煎剂（12%）和蒸煮剂（6%），均为口服给药。常用的植物部位是根（32%）、叶（11.5%）和果实（7%）。讨论/结论参试者报告的各种糖尿病效应均得到文献的肯定。该研究建议使用民族药用植物作为糖尿病药物的替代和补充。

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引用次数: 0

Eladi Churna and Draksharishta Improve Clinical Features and Functional Status of Lungs in Patients With Stable Chronic Bronchitis Eladi Churna和Draksharishta改善稳定期慢性支气管炎患者的临床特征和肺功能状态

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-04-10 DOI: 10.1016/j.hermed.2025.101015

H. Singh , B. Yadav , R.K. Ravte , S. Baheti , P.G. Nair , B.C.S. Rao , R. Rana , R. Singhal , N. Srikanth , R. Acharya

Introduction

Chronic bronchitis (CB) is a common pulmonary disease that is a significant cause of morbidity and mortality worldwide, and better healthcare approaches are still needed. As such, Ayurvedic therapies must be explored to manage CB. The purpose of this trial was to examine and validate the clinical efficacy and safety of Eladi Churna and Draksharishta for the management of stable CB.

Methods

A total of 130 participants with stable CB were registered in this study, out of which 110 participants completed the trial. Eladi Churna was given orally in a dose of 3 g thrice a day with honey after food. Draksharishta was administered orally in a dose of 20 ml twice daily for 84 days with an equal quantity of water after food.

Results

The effectiveness and safety of Ayurvedic therapy were assessed using clinical characteristics, the forced expiratory volume in 1 s score and the peak expiratory flow rate, the Leicester cough questionnaire score, the St George's respiratory questionnaire score, and hematological and biochemical investigations which were measured at the initiation of the trial and after completion of the trial. Clinical characteristics, forced expiratory volume in 1 s score, peak expiratory flow rate, Leicester cough questionnaire score, and St George's respiratory questionnaire scores were improved significantly with these trial medicines. The results showed that the participants who consumed these medicines had no adverse side effects.

Conclusions

Eladi Churna and Draksharishta is beneficial and safe in long-term use to improve the clinical features and functional status of the lungs of patients with CB.

慢性支气管炎（CB）是一种常见的肺部疾病，是世界范围内发病率和死亡率的重要原因，仍然需要更好的医疗保健方法。因此，必须探索阿育吠陀疗法来管理CB。本试验的目的是检查和验证Eladi Churna和Draksharishta治疗稳定型CB的临床疗效和安全性。方法本研究共纳入稳定型CB患者130例，其中110例完成试验。Eladi Churna以3 g的剂量口服，每天三次，餐后加蜂蜜。Draksharishta以20 ml的剂量口服，每天两次，连续84天，并在进食后等量的水。结果通过临床特征、1 s用力呼气量评分和呼气峰值流速、莱斯特咳嗽问卷评分、圣乔治呼吸问卷评分以及试验开始时和试验结束后的血液学和生化指标来评估阿育吠陀治疗的有效性和安全性。临床特征、用力呼气量1 s评分、呼气峰流速、莱斯特咳嗽问卷评分、圣乔治呼吸问卷评分均显著改善。结果显示，服用这些药物的参与者没有不良副作用。结论长期应用舒氏散对改善CB患者的临床特征和肺功能状况是有益且安全的。

{"title":"Eladi Churna and Draksharishta Improve Clinical Features and Functional Status of Lungs in Patients With Stable Chronic Bronchitis","authors":"H. Singh , B. Yadav , R.K. Ravte , S. Baheti , P.G. Nair , B.C.S. Rao , R. Rana , R. Singhal , N. Srikanth , R. Acharya","doi":"10.1016/j.hermed.2025.101015","DOIUrl":"10.1016/j.hermed.2025.101015","url":null,"abstract":"<div><h3>Introduction</h3><div>Chronic bronchitis (<strong>CB</strong>) is a common pulmonary disease that is a significant cause of morbidity and mortality worldwide, and better healthcare approaches are still needed. As such, <em>Ayurvedic</em> therapies must be explored to manage CB. The purpose of this trial was to examine and validate the clinical efficacy and safety of <em>Eladi Churna</em> and <em>Draksharishta</em> for the management of stable CB.</div></div><div><h3>Methods</h3><div>A total of 130 participants with stable CB were registered in this study, out of which 110 participants completed the trial. <em>Eladi Churna</em> was given orally in a dose of 3 g thrice a day with honey after food. <em>Draksharishta</em> was administered orally in a dose of 20 ml twice daily for 84 days with an equal quantity of water after food.</div></div><div><h3>Results</h3><div>The effectiveness and safety of Ayurvedic therapy were assessed using clinical characteristics, the forced expiratory volume in 1 s score and the peak expiratory flow rate, the Leicester cough questionnaire score, the St George's respiratory questionnaire score, and hematological and biochemical investigations which were measured at the initiation of the trial and after completion of the trial. Clinical characteristics, forced expiratory volume in 1 s score, peak expiratory flow rate, Leicester cough questionnaire score, and St George's respiratory questionnaire scores were improved significantly with these trial medicines. The results showed that the participants who consumed these medicines had no adverse side effects.</div></div><div><h3>Conclusions</h3><div><em>Eladi Churna</em> and <em>Draksharishta</em> is beneficial and safe in long-term use to improve the clinical features and functional status of the lungs of patients with CB.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101015"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0