Journal of Herbal Medicine最新文献_第9页

Network Pharmacology and Molecular Docking Analysis Reveal the Therapeutic Potential of Artemisia annua L. in Systemic Lupus Erythematosus 网络药理学与分子对接分析揭示黄花蒿治疗系统性红斑狼疮的潜力

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-04-09 DOI: 10.1016/j.hermed.2025.101013

Wenqin Huang , Jinhe Xiong

Introduction

Artemisia annua L., a traditional Chinese herb, has been used to manage inflammatory diseases, including systemic lupus erythematosus (SLE). However, its active components and molecular mechanisms in treating SLE remain unclear.

Methods

Active compounds were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform with criteria of drug-likeness ≥0.18 and oral bioavailability ≥30%. SLE-related genes were retrieved from DrugBank, Online Mendelian Inheritance in Man, Therapeutic Target Database, and GeneCards using the search term ‘systemic lupus erythematosus.’ Protein–protein interaction networks were constructed using Search Tool for the Retrieval of Interacting Genes/Proteins, and the Kyoto Encyclopaedia of Genes and Genomes and Gene Ontology enrichment analyses were performed via the DAVID platform. Molecular docking was conducted using AutoDock software.

Results

Eight core disease-related genes and five key active compounds were identified through topological analysis. Gene ontology and kyoto encyclopaedia of genes and genomes analyses indicated that the compounds primarily influenced cancer development risk, negative regulation of cell death, and related signalling pathways. Molecular docking confirmed strong binding affinities between key phytochemicals and core SLE targets .

Conclusions

The active compounds identified in this study target the following genes: interleukin-6, tumour protein p53, epidermal growth factor receptor, protein kinase B, interleukin-1 beta, tumour necrosis factor, jun proto-oncogene, and B-cell lymphoma 2, which regulate inflammation, T-cell differentiation, and apoptosis. These findings suggest Artemisia annua L. is a source of multitarget therapeutic agents for SLE, warranting further experimental validation.

黄花蒿（artemisia annua L.）是一种传统中药，已被用于治疗炎性疾病，包括系统性红斑狼疮（SLE）。然而，其治疗SLE的活性成分和分子机制尚不清楚。方法采用中药系统药理学数据库和分析平台，以药物相似度≥0.18、口服生物利用度≥30%为标准对活性化合物进行鉴定。通过搜索词“系统性红斑狼疮”，从DrugBank、在线孟德尔遗传（Online Mendelian Inheritance in Man）、Therapeutic Target Database和GeneCards检索sle相关基因。使用Search Tool for Retrieval of Interacting Genes/Proteins构建蛋白-蛋白互作网络，通过DAVID平台进行京都基因与基因组百科全书和基因本体富集分析。利用AutoDock软件进行分子对接。结果通过拓扑分析鉴定出8个核心疾病相关基因和5个关键活性化合物。基因本体论和京都基因和基因组百科分析表明，这些化合物主要影响癌症发展风险、细胞死亡的负调控以及相关的信号通路。分子对接证实了关键植物化学物质与SLE核心靶点之间具有很强的结合亲和力。结论本研究发现的活性化合物靶向以下基因：白细胞介素-6、肿瘤蛋白p53、表皮生长因子受体、蛋白激酶B、白细胞介素-1 β、肿瘤坏死因子、原癌基因和B细胞淋巴瘤2，这些基因调节炎症、t细胞分化和凋亡。这些发现表明，黄花蒿是SLE多靶点治疗药物的来源，需要进一步的实验验证。

{"title":"Network Pharmacology and Molecular Docking Analysis Reveal the Therapeutic Potential of Artemisia annua L. in Systemic Lupus Erythematosus","authors":"Wenqin Huang , Jinhe Xiong","doi":"10.1016/j.hermed.2025.101013","DOIUrl":"10.1016/j.hermed.2025.101013","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Artemisia annua L.</em>, a traditional Chinese herb, has been used to manage inflammatory diseases, including systemic lupus erythematosus (<strong>SLE</strong>). However, its active components and molecular mechanisms in treating SLE remain unclear.</div></div><div><h3>Methods</h3><div>Active compounds were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform with criteria of drug-likeness ≥0.18 and oral bioavailability ≥30%. SLE-related genes were retrieved from DrugBank, Online Mendelian Inheritance in Man, Therapeutic Target Database, and GeneCards using the search term ‘systemic lupus erythematosus.’ Protein–protein interaction networks were constructed using Search Tool for the Retrieval of Interacting Genes/Proteins, and the Kyoto Encyclopaedia of Genes and Genomes and Gene Ontology enrichment analyses were performed via the DAVID platform. Molecular docking was conducted using AutoDock software.</div></div><div><h3>Results</h3><div>Eight core disease-related genes and five key active compounds were identified through topological analysis. Gene ontology and kyoto encyclopaedia of genes and genomes analyses indicated that the compounds primarily influenced cancer development risk, negative regulation of cell death, and related signalling pathways. Molecular docking confirmed strong binding affinities between key phytochemicals and core SLE targets .</div></div><div><h3>Conclusions</h3><div>The active compounds identified in this study target the following genes: interleukin-6, tumour protein p53, epidermal growth factor receptor, protein kinase B, interleukin-1 beta, tumour necrosis factor, jun proto-oncogene, and B-cell lymphoma 2, which regulate inflammation, T-cell differentiation, and apoptosis. These findings suggest <em>Artemisia annua L.</em> is a source of multitarget therapeutic agents for SLE, warranting further experimental validation.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101013"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Triphalakatakanpathadi Kashaya on glycaemic control and quality of life in type 2 diabetes mellitus in Sri Lankan population – A descriptive observational study Triphalakatakanpathadi Kashaya对斯里兰卡2型糖尿病患者血糖控制和生活质量的影响——一项描述性观察研究

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-04-01 DOI: 10.1016/j.hermed.2025.101014

A.M.H.S. Attanayake , A. Upadhyay , R.P. Mendis , C.P. Kahingalage , W. Weerapana , A.K. Sahu , U.M.G.D. De Silva

Introduction

Diabetes mellitus (DM) presents a significant global health burden, often leading to complications and reduced quality of life. Ayurveda, a traditional system of medicine practiced globally, often uses Kashaya (herbal decoctions) for the management of diabetes.

Aim

This article aims to assess the effect of Triphalakatakanpathadi Kashaya (TKPK) on glycemic control and quality of life in patients with type 2 diabetes.

Material and methods

A descriptive observational study was conducted involving 46 patients treated with TKPK for six months at Bandaranaike Memorial Ayurveda Research Institute (BMARI), Sri Lanka. Data on glycemic parameters, diabetes related signs and symptoms, and quality of life using the short form of quality of life questionnaire (SF-36) were collected and analyzed using paired t-test, and Wilcoxon signed rank test.

Results

TKPK led to significant reduction in mean baseline value of HbAIc from 7.11% to 6.58% (p < 0.05) and mean baseline fasting blood sugar level from 172.4 ± 6.03 mg/dl to 141.4±4.99 mg/dl (p < 0.05) after six months. Significant improvements (p < 0.05) were observed in diabetes related signs and symptoms. Transaminases (AST & ALT) and serum creatinine levels remained within normal ranges throughout the study period reflecting the safety of TKPK. Quality of life was enhanced significantly (p < 0.05) in all the patients.

Conclusion

TKPK demonstrates the efficacy to lower blood glucose and improve the quality of life in type 2 DM patients. Scientific evidence of TKPK’s ingredients, suggest anti-inflammatory and anti-oxidant properties as contributing factors for its hypoglycemic effect. However, observational study imposes limitations, and warrant further clinical trials to establish the efficacy of this formulation.

糖尿病（DM）是一项重大的全球健康负担，经常导致并发症和生活质量下降。阿育吠陀是一种传统的全球医学体系，经常使用卡沙亚（草药煎剂）来治疗糖尿病。目的探讨TKPK （Triphalakatakanpathadi Kashaya）对2型糖尿病患者血糖控制及生活质量的影响。材料和方法在斯里兰卡Bandaranaike纪念阿育吠陀研究所（BMARI）进行了一项描述性观察性研究，涉及46例接受TKPK治疗6个月的患者。采用生活质量问卷（SF-36）收集血糖参数、糖尿病相关体征和症状及生活质量数据，采用配对t检验和Wilcoxon符号秩检验进行分析。结果stkpk使HbAIc平均基线值从7.11%降至6.58% (p <；0.05)，平均基线空腹血糖从172.4±6.03 mg/dl降至141.4±4.99 mg/dl (p <；6个月后0.05)。显著改善(p <；糖尿病相关体征和症状差异无统计学意义（0.05）。转氨酶(AST &；ALT)和血清肌酐水平在整个研究期间保持在正常范围内，反映了TKPK的安全性。生活质量显著提高(p <；0.05)。结论tkpk对2型糖尿病患者具有降低血糖、改善生活质量的作用。TKPK成分的科学证据表明，抗炎和抗氧化特性是其降糖作用的重要因素。然而，观察性研究存在局限性，需要进一步的临床试验来确定该配方的有效性。

{"title":"Effect of Triphalakatakanpathadi Kashaya on glycaemic control and quality of life in type 2 diabetes mellitus in Sri Lankan population – A descriptive observational study","authors":"A.M.H.S. Attanayake , A. Upadhyay , R.P. Mendis , C.P. Kahingalage , W. Weerapana , A.K. Sahu , U.M.G.D. De Silva","doi":"10.1016/j.hermed.2025.101014","DOIUrl":"10.1016/j.hermed.2025.101014","url":null,"abstract":"<div><h3>Introduction</h3><div>Diabetes mellitus (DM) presents a significant global health burden, often leading to complications and reduced quality of life. Ayurveda, a traditional system of medicine practiced globally, often uses <em>Kashaya</em> (herbal decoctions) for the management of diabetes.</div></div><div><h3>Aim</h3><div>This article aims to assess the effect of <em>Triphalakatakanpathadi Kashaya</em> (TKPK) on glycemic control and quality of life in patients with type 2 diabetes.</div></div><div><h3>Material and methods</h3><div>A descriptive observational study was conducted involving 46 patients treated with TKPK for six months at Bandaranaike Memorial Ayurveda Research Institute (BMARI), Sri Lanka. Data on glycemic parameters, diabetes related signs and symptoms, and quality of life using the short form of quality of life questionnaire (SF-36) were collected and analyzed using paired t-test, and Wilcoxon signed rank test.</div></div><div><h3>Results</h3><div>TKPK led to significant reduction in mean baseline value of HbAIc from 7.11% to 6.58% (<em>p</em> < 0.05) and mean baseline fasting blood sugar level from 172.4 ± 6.03 mg/dl to 141.4±4.99 mg/dl (<em>p</em> < 0.05) after six months. Significant improvements (<em>p</em> < 0.05) were observed in diabetes related signs and symptoms. Transaminases (AST & ALT) and serum creatinine levels remained within normal ranges throughout the study period reflecting the safety of TKPK. Quality of life was enhanced significantly (<em>p</em> < 0.05) in all the patients.</div></div><div><h3>Conclusion</h3><div>TKPK demonstrates the efficacy to lower blood glucose and improve the quality of life in type 2 DM patients. Scientific evidence of TKPK’s ingredients, suggest anti-inflammatory and anti-oxidant properties as contributing factors for its hypoglycemic effect. However, observational study imposes limitations, and warrant further clinical trials to establish the efficacy of this formulation.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101014"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Chinese Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy: Systematic Review and Meta-analysis 口服中草药治疗化疗引起的周围神经病变：系统评价和荟萃分析

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-03-25 DOI: 10.1016/j.hermed.2025.101009

Jiaqian Zuo , Peipei Yang , Xiaotao Niu , Qiurong Li , Wenqin Ren , Yujie Huang , Peng Shu

Introduction

It is estimated that about 30% of patients who received chemotherapy will develop chemotherapy-induced peripheral neuropathy (CIPN). Chinese herbal medicine is widely used to treat CIPN in China, but its efficacy has not been investigated. Our study aims to review the current literature on the effectiveness of oral herbal medicine in controlling the symptoms of CIPN.

Methods

Up until July 2024, relevant international databases were searched. Chemotherapy-induced peripheral neuropathy treated with oral Chinese herbal medicine in randomised controlled trials was included. The effective rate of the improving grade of peripheral nerve injury, nerve conduction velocity, Karnofsky performance score (KPS), and traditional Chinese medicine (TCM) syndrome efficiency were the outcomes; the increase in ALT, AST, and the incidence of vomiting were used as safety indicators.

Results

This review included 14 articles. The overall effect of oral Chinese herbal medicine on CIPN is statistically significant, suggesting that herbal medicine can benefit patients suffering from CIPN. The intervention group shows significant differences in the effective rate of improving the grade of peripheral nerve injury (P＜0.05), sensory nerve conduction velocity (P ≤ 0.05), KPSs (P＜0.05), and the TCM syndrome efficiency (P＜0.05) when compared with the control groups. However, the motor nerve conduction velocity (P＞0.05) shows no statistically significant difference.

Conclusions

Oral Chinese herbal medicine is an effective method to relieve CIPN symptoms and can increase the effective rate of improving the grade of peripheral nerve injury, sensory nerve conduction velocity, KPSs, and TCM syndrome efficiency, and it has a good security.

Prospero

CRD42023493091.

据估计，约30%接受化疗的患者会发生化疗诱导的周围神经病变（CIPN）。中草药在中国被广泛用于治疗CIPN，但其疗效尚未得到研究。我们的研究旨在回顾目前关于口服草药控制CIPN症状的有效性的文献。方法检索至2024年7月的国际相关数据库。随机对照试验纳入口服中草药治疗化疗诱导的周围神经病变。观察周围神经损伤改善程度的有效率、神经传导速度、Karnofsky表现评分（KPS）、中医证候疗效；以ALT、AST升高和呕吐发生率作为安全性指标。结果本综述纳入14篇文献。口服中草药对CIPN的总体影响具有统计学意义，提示中草药对CIPN患者有益。干预组在改善周围神经损伤程度的有效率（P<0.05）、感觉神经传导速度（P ≤ 0.05）、kpi （P<0.05）、中医证候疗效（P<0.05）等方面与对照组比较均有显著差异。而运动神经传导速度差异无统计学意义（P < 0.05）。结论口服中草药是缓解CIPN症状的有效方法，可提高周围神经损伤程度、感觉神经传导速度、kps和中医证候疗效的有效率，且具有较好的安全性。

{"title":"Oral Chinese Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy: Systematic Review and Meta-analysis","authors":"Jiaqian Zuo , Peipei Yang , Xiaotao Niu , Qiurong Li , Wenqin Ren , Yujie Huang , Peng Shu","doi":"10.1016/j.hermed.2025.101009","DOIUrl":"10.1016/j.hermed.2025.101009","url":null,"abstract":"<div><h3>Introduction</h3><div>It is estimated that about 30% of patients who received chemotherapy will develop chemotherapy-induced peripheral neuropathy (<strong>CIPN</strong>). Chinese herbal medicine is widely used to treat CIPN in China, but its efficacy has not been investigated. Our study aims to review the current literature on the effectiveness of oral herbal medicine in controlling the symptoms of CIPN.</div></div><div><h3>Methods</h3><div>Up until July 2024, relevant international databases were searched. Chemotherapy-induced peripheral neuropathy treated with oral Chinese herbal medicine in randomised controlled trials was included. The effective rate of the improving grade of peripheral nerve injury, nerve conduction velocity, Karnofsky performance score (<strong>KPS</strong>), and traditional Chinese medicine (<strong>TCM</strong>) syndrome efficiency were the outcomes; the increase in ALT, AST, and the incidence of vomiting were used as safety indicators.</div></div><div><h3>Results</h3><div>This review included 14 articles. The overall effect of oral Chinese herbal medicine on CIPN is statistically significant, suggesting that herbal medicine can benefit patients suffering from CIPN. The intervention group shows significant differences in the effective rate of improving the grade of peripheral nerve injury (<em>P</em>＜0.05), sensory nerve conduction velocity (<em>P</em> ≤ 0.05), KPSs (<em>P</em>＜0.05), and the TCM syndrome efficiency (<em>P</em>＜0.05) when compared with the control groups. However, the motor nerve conduction velocity (<em>P</em>＞0.05) shows no statistically significant difference.</div></div><div><h3>Conclusions</h3><div>Oral Chinese herbal medicine is an effective method to relieve CIPN symptoms and can increase the effective rate of improving the grade of peripheral nerve injury, sensory nerve conduction velocity, KPSs, and TCM syndrome efficiency, and it has a good security.</div></div><div><h3>Prospero</h3><div>CRD42023493091.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101009"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of herbal medicine for cancer therapy in Indonesia: a prospective cohort study 在印度尼西亚使用草药治疗癌症：一项前瞻性队列研究

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-02-04 DOI: 10.1016/j.hermed.2025.100991

Zulvikar Syambani Ulhaq , Delima , Lucie Widowati , Pramita Andarwati , Elga Renjana , Elok Firdiana , Lola Ayu Istifiani , Syafrizal Aji Pamungkas

Introduction

Herbal medicine is widely used in Indonesia, including for cancer treatment, but data on its effectiveness is limited. This study aimed to assess the effectiveness of herbal medicine in cancer patients by evaluating their wellness index (WI), compliance, and herb usage patterns.

Methods

Data were obtained from the Jamu Registry for the period from 2014 to 2018. The improvement in patients' health status was assessed by quantifying the WI score, a modification of the World Health Organization's (WHO’s) quality of life (QoL) measure. Additionally, drug compliance and patterns of commonly used herbs were also evaluated.

Results

This study involved 130 participants, 82.3% of whom were female, with 33% diagnosed with breast cancer. Preference for herbal medicine alone was associated with older age, lower education, and rural residence. The six most commonly prescribed herbs were Andrographis paniculata, Catharanthus roseus, Curcuma zanthorrhiza, Gynura divaricata, Physalis angulata, and Centella asiatica. Overall, 75.4% of patients improved their WI score, with greater improvement in those using only herbal medicine (81.9%) compared to complementary therapies (48%) (P = 0.001). Drug compliance was good, with 72.3% adhering to their regimen. In silico analysis highlighted anti-cancer properties in these herbs, with α-tocopherol from P. angulata and kaempferol-3-O-β-D-glucopyranoside from G. divaricata showing potent effects, modulated by ERα and MDM2, both linked to breast cancer.

Conclusion

Herbal medicine is widely regarded as a complementary and alternative treatment option for cancer patients in Indonesia. Our study further demonstrates that the use of herbal medicine contributes to an improvement in the overall well-being of these patients.

草药在印度尼西亚被广泛使用，包括用于癌症治疗，但是关于其有效性的数据有限。本研究旨在通过评估癌症患者的健康指数（WI）、依从性和草药使用模式来评估草药对癌症患者的有效性。方法数据来自2014 - 2018年的Jamu Registry。通过量化WI评分来评估患者健康状况的改善，WI评分是世界卫生组织（WHO）生活质量（QoL）衡量标准的一种修改。此外，还评估了常用草药的药物依从性和模式。该研究涉及130名参与者，其中82.3%为女性，其中33%被诊断患有乳腺癌。仅偏爱草药与年龄较大、受教育程度较低、居住在农村有关。最常用的六种草药是穿心莲、花楸花、花椒姜黄、花楸花、角Physalis和积雪草。总体而言，75.4%的患者改善了他们的WI评分，与补充疗法（48%）相比，仅使用草药的患者（81.9%）改善更大（P = 0.001）。药物依从性良好，72.3%的患者坚持服药。硅分析强调了这些草药的抗癌特性，其中角蒿中的α-生育酚和山奈酚-3- 0 -β- d -葡萄糖吡喃苷在ERα和MDM2的调节下显示出强有力的作用，两者都与乳腺癌有关。结论在印度尼西亚，草药被广泛认为是癌症患者的补充和替代治疗选择。我们的研究进一步表明，使用草药有助于改善这些患者的整体健康状况。

{"title":"The use of herbal medicine for cancer therapy in Indonesia: a prospective cohort study","authors":"Zulvikar Syambani Ulhaq , Delima , Lucie Widowati , Pramita Andarwati , Elga Renjana , Elok Firdiana , Lola Ayu Istifiani , Syafrizal Aji Pamungkas","doi":"10.1016/j.hermed.2025.100991","DOIUrl":"10.1016/j.hermed.2025.100991","url":null,"abstract":"<div><h3>Introduction</h3><div>Herbal medicine is widely used in Indonesia, including for cancer treatment, but data on its effectiveness is limited. This study aimed to assess the effectiveness of herbal medicine in cancer patients by evaluating their wellness index (WI), compliance, and herb usage patterns.</div></div><div><h3>Methods</h3><div>Data were obtained from the <em>Jamu Registry</em> for the period from 2014 to 2018. The improvement in patients' health status was assessed by quantifying the WI score, a modification of the World Health Organization's (WHO’s) quality of life (QoL) measure. Additionally, drug compliance and patterns of commonly used herbs were also evaluated.</div></div><div><h3>Results</h3><div>This study involved 130 participants, 82.3% of whom were female, with 33% diagnosed with breast cancer. Preference for herbal medicine alone was associated with older age, lower education, and rural residence. The six most commonly prescribed herbs were <em>Andrographis paniculata</em>, <em>Catharanthus roseus</em>, <em>Curcuma zanthorrhiza</em>, <em>Gynura divaricata</em>, <em>Physalis angulata</em>, and <em>Centella asiatica</em>. Overall, 75.4% of patients improved their WI score, with greater improvement in those using only herbal medicine (81.9%) compared to complementary therapies (48%) (<em>P</em> = 0.001). Drug compliance was good, with 72.3% adhering to their regimen. <em>In silico</em> analysis highlighted anti-cancer properties in these herbs, with α-tocopherol from <em>P. angulata</em> and kaempferol-3-O-β-D-glucopyranoside from <em>G. divaricata</em> showing potent effects, modulated by ERα and MDM2, both linked to breast cancer.</div></div><div><h3>Conclusion</h3><div>Herbal medicine is widely regarded as a complementary and alternative treatment option for cancer patients in Indonesia. Our study further demonstrates that the use of herbal medicine contributes to an improvement in the overall well-being of these patients.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 100991"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological Screening of Four Medicinal Lamiaceae Plants, Two of Which Are Endemic to Türkiye: Apoptotic and Cytotoxic Characteristics 四种Lamiaceae药用植物的药理筛选，其中两种是台湾特有的：凋亡和细胞毒性特性

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-04-23 DOI: 10.1016/j.hermed.2025.101020

Arzu KASKA , Mücahit SEÇME

Introduction

Lamiaceae plants possess anticancer, antioxidant, and antimicrobial activities due to their phytochemical constituents. The aim of this study is to investigate the effects of the hydroethanolic extracts of four medicinal Lamiaceae plants (Thymus zygioides, Teucrium sandrasicum, Origanum sipyleum, Nepeta italica subsp. cadmea) to apoptosis and cell cycle on MDA-MB-231 breast cancer cell line.

Methods

The cytotoxic effects of hydroethanolic extracts of these medicinal Lamiaceae plants on cell viability in the MDA-MB-231 cell line were determined by XTT assay. mRNA expression changes of apoptosis and cell-cycle checkpoint regulators (Bax, Bcl-2, H19, RNU43, caspase-3, caspase-8, caspase-9, cyclin D1, CDK 4, CDK 6) were evaluated by real-time PCR.

Results

The hydroethanolic extracts from four medicinal Lamiaceae plants have exhibited high antiproliferative activity in MDA-MB-231 breast cancer cells according to time and concentration-dependent manner.

Conclusions

The potential application of these Lamiaceae medicinal plants as an antiproliferative agent is an important step in understanding the medicinal use of plants in Türkiye.

lamiaceae植物由于其化学成分而具有抗癌、抗氧化和抗菌活性。研究了四种Lamiaceae药用植物（thyymus zygioides, Teucrium sandrasicum, Origanum sipyleum, Nepeta italica subsp.）的水乙醇提取物的药理作用。MDA-MB-231乳腺癌细胞株对凋亡和细胞周期的影响。方法采用XTT法测定这些Lamiaceae药用植物水乙醇提取物对MDA-MB-231细胞株细胞活力的细胞毒作用。实时荧光定量PCR检测细胞凋亡和细胞周期检查点调节因子Bax、Bcl-2、H19、RNU43、caspase-3、caspase-8、caspase-9、cyclin D1、cdk4、cdk6的mRNA表达变化。结果四种Lamiaceae药用植物水乙醇提取物对MDA-MB-231乳腺癌细胞均表现出较强的抗增殖活性，且呈时间依赖性和浓度依赖性。结论这些Lamiaceae药用植物作为抗增殖药物的潜在应用是了解植物在 rkiye中的药用价值的重要一步。

{"title":"Pharmacological Screening of Four Medicinal Lamiaceae Plants, Two of Which Are Endemic to Türkiye: Apoptotic and Cytotoxic Characteristics","authors":"Arzu KASKA , Mücahit SEÇME","doi":"10.1016/j.hermed.2025.101020","DOIUrl":"10.1016/j.hermed.2025.101020","url":null,"abstract":"<div><h3>Introduction</h3><div>Lamiaceae plants possess anticancer, antioxidant, and antimicrobial activities due to their phytochemical constituents. The aim of this study is to investigate the effects of the hydroethanolic extracts of four medicinal Lamiaceae plants (<em>Thymus zygioides, Teucrium sandrasicum, Origanum sipyleum, Nepeta italica</em> subsp. <em>cadmea</em>) to apoptosis and cell cycle on MDA-MB-231 breast cancer cell line.</div></div><div><h3>Methods</h3><div>The cytotoxic effects of hydroethanolic extracts of these medicinal Lamiaceae plants on cell viability in the MDA-MB-231 cell line were determined by XTT assay. mRNA expression changes of apoptosis and cell-cycle checkpoint regulators (Bax, Bcl-2, H19, RNU43, caspase-3, caspase-8, caspase-9, cyclin D1, CDK 4, CDK 6) were evaluated by real-time PCR.</div></div><div><h3>Results</h3><div>The hydroethanolic extracts from four medicinal Lamiaceae plants have exhibited high antiproliferative activity in MDA-MB-231 breast cancer cells according to time and concentration-dependent manner.</div></div><div><h3>Conclusions</h3><div>The potential application of these Lamiaceae medicinal plants as an antiproliferative agent is an important step in understanding the medicinal use of plants in Türkiye.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101020"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of different traditional Chinese medicine treatment for Corona Virus Disease 2019: systematic review and meta-analysis 不同中药治疗2019冠状病毒病的疗效：系统评价和荟萃分析

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-02-21 DOI: 10.1016/j.hermed.2025.101001

Su Youzhu, Su Rui, Wang Shuo, Liu Mifeng, Fan Jie, Liu Qingquan

Objective

To evaluate the efficacy of different treatment methods currently used for COVID-19 infection, providing evidence-based support for treatment decision-making.

Methods

Effective drugs for COVID-19 were selected through literature research. Based on the pharmacological effects of the drugs, they were categorised into three treatment methods: Dispersing lung qi and detoxification; Dispersing lung qi, detoxification and eliminating dampness; Dispersing lung qi, detoxification, eliminating dampness and activating qi. Meta-analysis was conducted to evaluate the efficacy of these three treatment methods, clarifying the advantages of different treatment methods.

Results

All three treatment methods showed advantages in various aspects such as shortening fever duration, time to nucleic acid conversion, reducing the rate of severe cases, increasing the recovery rate of chest CT scans, and disappearance rate of cough. Dispersing lung qi and detoxification method showed significant advantages in shortening sore throat duration (P < 0.01), while the other two methods showed significant advantages in improving the disappearance rate of chest tightness, shortening the duration of fatigue, and cough duration.

Conclusion

All three treatment methods have shown significant efficacy, providing evidence for the comprehensive treatment of epidemic diseases in traditional Chinese medicine. Dispersing lung qi and detoxification method is suitable for patients with obvious heat symptoms, while Dispersing lung qi, detoxification and eliminating dampness and Dispersing lung qi, detoxification, eliminating dampness and activating qi method can regulate the spleen to remove dampness, dredge and regulate the three jiao qi mechanism, fitting the core pathogenesis of COVID-19 involves dampness, toxin, stagnation and closure.

目的评价目前新型冠状病毒感染不同治疗方法的疗效，为治疗决策提供循证支持。方法通过文献研究，选择治疗COVID-19的有效药物。根据药物的药理作用，将其分为三种治疗方法：散肺解毒；散肺气，解毒祛湿；散肺气、解毒、祛湿、活气。对三种治疗方法的疗效进行meta分析，明确不同治疗方法的优势。结果三种治疗方法在缩短发热时间、核酸转化时间、降低重症率、提高胸部CT恢复率、咳嗽消失率等方面均具有优势。散肺解毒法对缩短咽喉痛病程有显著优势(P <；0.01)，而其他两种方法在提高胸闷消失率、缩短疲劳持续时间、咳嗽持续时间等方面均有显著优势。结论三种治疗方法疗效显著，为中医综合治疗流行性疾病提供了依据。散肺气解毒法适用于热证明显的患者，而散肺气解毒祛湿法和散肺气解毒祛湿活气法可调节脾去湿、疏通、调节三焦气机制，符合新冠肺炎湿、毒、郁、闭的核心病机。

{"title":"The efficacy of different traditional Chinese medicine treatment for Corona Virus Disease 2019: systematic review and meta-analysis","authors":"Su Youzhu, Su Rui, Wang Shuo, Liu Mifeng, Fan Jie, Liu Qingquan","doi":"10.1016/j.hermed.2025.101001","DOIUrl":"10.1016/j.hermed.2025.101001","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of different treatment methods currently used for COVID-19 infection, providing evidence-based support for treatment decision-making.</div></div><div><h3>Methods</h3><div>Effective drugs for COVID-19 were selected through literature research. Based on the pharmacological effects of the drugs, they were categorised into three treatment methods: Dispersing lung qi and detoxification; Dispersing lung qi, detoxification and eliminating dampness; Dispersing lung qi, detoxification, eliminating dampness and activating qi. Meta-analysis was conducted to evaluate the efficacy of these three treatment methods, clarifying the advantages of different treatment methods.</div></div><div><h3>Results</h3><div>All three treatment methods showed advantages in various aspects such as shortening fever duration, time to nucleic acid conversion, reducing the rate of severe cases, increasing the recovery rate of chest CT scans, and disappearance rate of cough. Dispersing lung qi and detoxification method showed significant advantages in shortening sore throat duration (<em>P</em> < 0.01), while the other two methods showed significant advantages in improving the disappearance rate of chest tightness, shortening the duration of fatigue, and cough duration.</div></div><div><h3>Conclusion</h3><div>All three treatment methods have shown significant efficacy, providing evidence for the comprehensive treatment of epidemic diseases in traditional Chinese medicine. Dispersing lung qi and detoxification method is suitable for patients with obvious heat symptoms, while Dispersing lung qi, detoxification and eliminating dampness and Dispersing lung qi, detoxification, eliminating dampness and activating qi method can regulate the spleen to remove dampness, dredge and regulate the three jiao qi mechanism, fitting the core pathogenesis of COVID-19 involves dampness, toxin, stagnation and closure.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101001"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of Vaccination and Herbal Supplement Usage Preferences Among African Populations During Coronavirus Disease 2019 Pandemic: A Scoping Review 2019冠状病毒病大流行期间非洲人群疫苗接种和草药补充剂使用偏好的探索：范围审查

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-04-11 DOI: 10.1016/j.hermed.2025.101016

A.A. Onyeaghala , A.F. Anyiam , D.C. Husaini , J.H. Chiroma , O.C. Arinze-Anyiam

Introduction

The coronavirus disease 2019 (COVID-19) pandemic has driven global mitigation efforts, including vaccination campaigns and the exploration of herbal supplements. In Africa, where diverse cultural and healthcare landscapes vary, understanding the preferences and perceptions surrounding the use of vaccination and herbal supplements is crucial for effective public health interventions. This study aims to examine vaccination and herbal supplement usage preferences among African populations during the COVID-19 pandemic.

Methods

A scoping review synthesised literatures on vaccination and herbal supplement preferences. Searches were conducted in Google Scholar, PubMed, ResearchGate, and Embase for studies published in English between January 2020 and December 2023. Relevant themes and patterns were identified through data extraction and synthesis

Results

Attitudes towards vaccination varied and were influenced by factors such as vaccine hesitancy, mistrust in healthcare systems, cultural beliefs, and misinformation. Additionally, the use of herbal supplements was widespread, driven by cultural practices, accessibility, and perceived efficacy in COVID-19 prevention or treatment

Conclusions

This study highlights the complex interplay of factors shaping vaccination and herbal supplement preferences in Africa during the COVID-19 pandemic. Insights from this analysis can inform tailored interventions and policies to address COVID-19 and future public health challenges in Africa.

2019年冠状病毒病（COVID-19）大流行推动了全球缓解努力，包括疫苗接种运动和草药补充剂的探索。在非洲，文化和卫生保健状况各不相同，了解围绕疫苗接种和草药补充剂使用的偏好和看法对于有效的公共卫生干预至关重要。本研究旨在研究COVID-19大流行期间非洲人口的疫苗接种和草药补充剂使用偏好。方法进行范围综述，综合有关疫苗接种和草药补充剂偏好的文献。在b谷歌Scholar、PubMed、ResearchGate和Embase中检索了2020年1月至2023年12月期间发表的英文研究。结果对疫苗接种的态度各不相同，并受到疫苗犹豫、对卫生保健系统的不信任、文化信仰和错误信息等因素的影响。此外，受文化习俗、可及性和对COVID-19预防或治疗的有效性的影响，草药补充剂的使用很普遍。结论本研究强调了在COVID-19大流行期间，影响非洲疫苗接种和草药补充剂偏好的因素之间复杂的相互作用。从这一分析中获得的见解可以为量身定制的干预措施和政策提供信息，以应对2019冠状病毒病和非洲未来的公共卫生挑战。

{"title":"Exploration of Vaccination and Herbal Supplement Usage Preferences Among African Populations During Coronavirus Disease 2019 Pandemic: A Scoping Review","authors":"A.A. Onyeaghala , A.F. Anyiam , D.C. Husaini , J.H. Chiroma , O.C. Arinze-Anyiam","doi":"10.1016/j.hermed.2025.101016","DOIUrl":"10.1016/j.hermed.2025.101016","url":null,"abstract":"<div><h3>Introduction</h3><div>The coronavirus disease 2019 (<strong>COVID-19</strong>) pandemic has driven global mitigation efforts, including vaccination campaigns and the exploration of herbal supplements. In Africa, where diverse cultural and healthcare landscapes vary, understanding the preferences and perceptions surrounding the use of vaccination and herbal supplements is crucial for effective public health interventions. This study aims to examine vaccination and herbal supplement usage preferences among African populations during the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>A scoping review synthesised literatures on vaccination and herbal supplement preferences. Searches were conducted in Google Scholar, PubMed, ResearchGate, and Embase for studies published in English between January 2020 and December 2023. Relevant themes and patterns were identified through data extraction and synthesis</div></div><div><h3>Results</h3><div>Attitudes towards vaccination varied and were influenced by factors such as vaccine hesitancy, mistrust in healthcare systems, cultural beliefs, and misinformation. Additionally, the use of herbal supplements was widespread, driven by cultural practices, accessibility, and perceived efficacy in COVID-19 prevention or treatment</div></div><div><h3>Conclusions</h3><div>This study highlights the complex interplay of factors shaping vaccination and herbal supplement preferences in Africa during the COVID-19 pandemic. Insights from this analysis can inform tailored interventions and policies to address COVID-19 and future public health challenges in Africa.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101016"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-target mechanism of Physalis angulata to treat malaria based on network pharmacology and molecular docking 基于网络药理学和分子对接的角Physalis治疗疟疾多靶点机制研究

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-01 Epub Date: 2025-04-29 DOI: 10.1016/j.hermed.2025.101021

Raden Bayu Indradi , Muhaimin Muhaimin , Melisa Intan Barliana , Alfi Khatib , Intan Timur Maisyarah , Dian Ayu Eka Pitaloka , Muhammad Fadhil Pratomo

Introduction

Antimalarial drug resistance, such as artemisinin partial resistance, has become a major concern in malaria eradication. Thus, the development of new alternatives for malaria treatment is needed. Medicinal plants used by people in endemic areas, such as Physalis angulata, need to be studied for their claimed efficacy to treat malaria.

Methods

In this study, we used a network pharmacology approach utilising several databases (KNApSAck, GeneCards, SwissADME, Pharmmapper, SwissTargetPrediction, SuperPred, STRING-DB, DAVID) to predict the multi-mechanism of P. angulata to alleviate malaria, as confirmed by molecular docking.

Results

The result revealed that 25 compounds of P. angulata interact with 22 malaria-related targets, where molecular docking performed for compounds and targets associated with malaria pathways verified that withangulatin F showed a good binding affinity with ICAM1, VCAM1, and SELE, physagulin A with IL1B, physagulin J with TNF, and physalin V with TLR4.

Conclusion

We predict that P. angulata alleviates malaria through several mechanisms, primarily by regulating the inflammatory response. This mechanism reduces excess proinflammatory cytokines like TNF and IL1B, leads to reduced levels of adhesion molecules, and ultimately reduces or prevents the severity of malaria.

抗疟药物耐药性，如青蒿素部分耐药性，已成为消除疟疾的一个主要问题。因此，需要开发新的疟疾治疗方法。在疟疾流行地区人们使用的药用植物，如Physalis angulata，需要对其声称的治疗疟疾的功效进行研究。方法采用网络药理学方法，利用KNApSAck、GeneCards、SwissADME、Pharmmapper、SwissTargetPrediction、SuperPred、STRING-DB、DAVID等多个数据库，预测角蒿缓解疟疾的多机制，并进行分子对接验证。结果发现，角田菁中有25个化合物与22个疟疾相关靶点相互作用，其中对与疟疾通路相关的化合物和靶点进行了分子对接，证实了withangulatin F与ICAM1、VCAM1和SELE具有良好的结合亲和力，physagulin a与IL1B、physagulin J与TNF、physalin V与TLR4具有良好的结合亲和力。结论我们预测角田葵通过多种机制缓解疟疾，主要是通过调节炎症反应。这一机制减少了过量的促炎细胞因子，如TNF和IL1B，导致粘附分子水平降低，最终降低或预防疟疾的严重程度。

{"title":"Multi-target mechanism of Physalis angulata to treat malaria based on network pharmacology and molecular docking","authors":"Raden Bayu Indradi , Muhaimin Muhaimin , Melisa Intan Barliana , Alfi Khatib , Intan Timur Maisyarah , Dian Ayu Eka Pitaloka , Muhammad Fadhil Pratomo","doi":"10.1016/j.hermed.2025.101021","DOIUrl":"10.1016/j.hermed.2025.101021","url":null,"abstract":"<div><h3>Introduction</h3><div>Antimalarial drug resistance, such as artemisinin partial resistance, has become a major concern in malaria eradication. Thus, the development of new alternatives for malaria treatment is needed. Medicinal plants used by people in endemic areas, such as <em>Physalis angulata</em>, need to be studied for their claimed efficacy to treat malaria.</div></div><div><h3>Methods</h3><div>In this study, we used a network pharmacology approach utilising several databases (KNApSAck, GeneCards, SwissADME, Pharmmapper, SwissTargetPrediction, SuperPred, STRING-DB, DAVID) to predict the multi-mechanism of <em>P. angulata</em> to alleviate malaria, as confirmed by molecular docking.</div></div><div><h3>Results</h3><div>The result revealed that 25 compounds of <em>P. angulata</em> interact with 22 malaria-related targets, where molecular docking performed for compounds and targets associated with malaria pathways verified that withangulatin F showed a good binding affinity with ICAM1, VCAM1, and SELE, physagulin A with IL1B, physagulin J with TNF, and physalin V with TLR4.</div></div><div><h3>Conclusion</h3><div>We predict that <em>P. angulata</em> alleviates malaria through several mechanisms, primarily by regulating the inflammatory response. This mechanism reduces excess proinflammatory cytokines like TNF and IL1B, leads to reduced levels of adhesion molecules, and ultimately reduces or prevents the severity of malaria.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101021"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactivities, medicinal properties, and advanced extraction techniques of Tarragon (Artemisia dracunculus): a comprehensive review 龙蒿（Artemisia dracunculus）生物活性、药用特性及先进提取技术综述

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-03-01 Epub Date: 2025-01-02 DOI: 10.1016/j.hermed.2024.100989

Syamand A. Qadir , Farhang H. Awlqadr , Miran H. Qadir , Sherzad R.A. Tobakari , Aryan M. Faraj , Sahar H. Hamarashid , Tablo H. Salih , Mohammed N. Saeed

Introduction

Throughout history, medicinal plants have been used as essential for humans treatment. The antibacterial applications of tarragon (Artemisia dracunculus) in phytotherapy will be covered in this review study. Despite the advancements in pharmaceuticals, herbal remedies continue to be vital, especially in areas where access to modern therapy is limited. In addition, the antibacterial qualities of Tarragon plant extracts and their innovative extraction techniques are described in this review article.

Methods

A thorough examination of the literature looked at the chemical composition, historical uses, and modern extraction techniques of tarragon (A. dracunculus). The extraction techniques, such as the in-syringe reversed dispersive liquid-liquid microextraction (IS-R-DLLME), ultrasound-assisted extraction (UAE), deep eutectic solvents (DES), and pressurised liquid extraction (PLE), and the methods of review analysis the antibacterial properties of tarragon (A. dracunculus) extracts against dangerous microbes.

Results

Both Gram-positive and Gram-negative bacteria can be effectively resistant by tarragon (A. dracunculus) essential oils and extracts. Also the primary bioactive components were limonene, methyl eugenol, and estragole. The yield and purity of bioactive components were enhanced by novel extraction techniques such as IS-R-DLLME and UAE. At minimum inhibitory concentrations (MIC). Therefore, the essential oils demonstrated strong antibacterial action against Escherichia coli and Staphylococcus aureus.

Discussion/Conclusions

The tarragon (A. dracunculus) plant may be regarded as a potent natural antibacterial agent, especially for antibiotic-resistant illnesses. By combining traditional botanical knowledge with contemporary extraction methods, new medicinal compounds can be created. This study highlighted the need to explore the synergistic effects of tarragon's bioactive components and improve extraction methods in order to optimise therapeutic advantages. Ultimately, tarragon (A. dracunculus) may help antibiotic resistance and microbial illnesses.

纵观历史，药用植物一直被用作人类治疗的必需品。本文就龙蒿（Artemisia dracunculus）在植物治疗中的抗菌应用进行综述。尽管药物取得了进步，但草药疗法仍然至关重要，特别是在获得现代疗法的机会有限的地区。此外，本文还对龙蒿植物提取物的抗菌特性及其创新的提取技术进行了综述。方法通过查阅文献，对龙蒿的化学成分、历史用途和现代提取技术进行分析。采用针内反相分散液-液微萃取法（IS-R-DLLME）、超声辅助萃取法（UAE）、深度共晶溶剂萃取法（DES）和加压液体萃取法（PLE）等提取技术，对龙蒿提取物对危险微生物的抑菌性能进行了综述分析。结果龙蒿精油和提取物对革兰氏阳性菌和革兰氏阴性菌均有较好的耐药性。主要生物活性成分为柠檬烯、甲基丁香酚和雌酮酚。采用IS-R-DLLME和UAE等新型提取技术，提高了生物活性成分的收率和纯度。最低抑制浓度（MIC）。因此，精油对大肠杆菌和金黄色葡萄球菌具有较强的抗菌作用。讨论/结论龙蒿（a . dracunculus）植物可能被认为是一种有效的天然抗菌剂，特别是对抗生素耐药性疾病。通过将传统植物学知识与现代提取方法相结合，可以创造出新的药用化合物。本研究强调有必要探索龙蒿生物活性成分的协同作用，改进提取方法，以优化治疗优势。最终，龙蒿可能有助于抗生素耐药性和微生物疾病。

{"title":"Bioactivities, medicinal properties, and advanced extraction techniques of Tarragon (Artemisia dracunculus): a comprehensive review","authors":"Syamand A. Qadir , Farhang H. Awlqadr , Miran H. Qadir , Sherzad R.A. Tobakari , Aryan M. Faraj , Sahar H. Hamarashid , Tablo H. Salih , Mohammed N. Saeed","doi":"10.1016/j.hermed.2024.100989","DOIUrl":"10.1016/j.hermed.2024.100989","url":null,"abstract":"<div><h3>Introduction</h3><div>Throughout history, medicinal plants have been used as essential for humans treatment. The antibacterial applications of tarragon (<em>Artemisia dracunculus</em>) in phytotherapy will be covered in this review study. Despite the advancements in pharmaceuticals, herbal remedies continue to be vital, especially in areas where access to modern therapy is limited. In addition, the antibacterial qualities of Tarragon plant extracts and their innovative extraction techniques are described in this review article.</div></div><div><h3>Methods</h3><div>A thorough examination of the literature looked at the chemical composition, historical uses, and modern extraction techniques of tarragon (<em>A. dracunculus</em>). The extraction techniques, such as the in-syringe reversed dispersive liquid-liquid microextraction (IS-R-DLLME), ultrasound-assisted extraction (UAE), deep eutectic solvents (DES), and pressurised liquid extraction (PLE), and the methods of review analysis the antibacterial properties of tarragon (<em>A. dracunculus</em>) extracts against dangerous microbes.</div></div><div><h3>Results</h3><div>Both Gram-positive and Gram-negative bacteria can be effectively resistant by tarragon (<em>A. dracunculus</em>) essential oils and extracts. Also the primary bioactive components were limonene, methyl eugenol, and estragole. The yield and purity of bioactive components were enhanced by novel extraction techniques such as IS-R-DLLME and UAE. At minimum inhibitory concentrations (MIC). Therefore, the essential oils demonstrated strong antibacterial action against <em>Escherichia coli</em> and <em>Staphylococcus aureus.</em></div></div><div><h3>Discussion/Conclusions</h3><div>The tarragon (<em>A. dracunculus</em>) plant may be regarded as a potent natural antibacterial agent, especially for antibiotic-resistant illnesses. By combining traditional botanical knowledge with contemporary extraction methods, new medicinal compounds can be created. This study highlighted the need to explore the synergistic effects of tarragon's bioactive components and improve extraction methods in order to optimise therapeutic advantages. Ultimately, tarragon (<em>A. dracunculus</em>) may help antibiotic resistance and microbial illnesses.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"50 ","pages":"Article 100989"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum biomarkers in rheumatoid arthritis patients and effect of Unani herbal formulation Qurs-e-Hudar on these biomarkers suggesting the anti-IL-6 effect 类风湿关节炎患者血清生物标志物及乌拉尼中药制剂对这些生物标志物的影响提示抗il -6作用

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1016/j.hermed.2025.100999

Towseef Amin Rafeeqi , Riyaz Ahmed Pandith , Humma , Arjumand Shah , Mohammad Zakir , Nighat Anjum , Irfat Ara , N. Zaheer Ahmed

Introduction

One of the herbal formulations known as Qurs-e-Hudar used in the Unani medicine for the treatment of rheumatoid arthritis (RA), has no known mechanism of action. In this endeavour, the effect of Qurs-e-Hudar on serum biomarkers in RA patients was evaluated.

Methods

In an open-label, single-centric clinical study, 26 RA patients were assessed for 6-week treatment by Qurs-e-Hudar in a dose of 250 mg twice a day. The serum was evaluated quantitatively for biomarkers including rheumatoid factor (RF), anti–cyclic citrullinated peptide (anti-CCP), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), tumour necrosis factor receptor 1 (TNFR1), vascular cell adhesion molecule 1 (VCAM1), interleukin 6 (IL-6), and chemokine ligand 13 (CXCL13) before and after treatment in RA patients and 26 healthy participants at once.

Results

The ESR, CRP, TNFR1, IL-6 and CXCL13 values were significantly high (P < 0.05) in RA patients comparing healthy controls. There was a significant reduction in (P < 0.05) in ESR and IL-6 values after treatment in RA patients. Although non-significant, a reduction in TNFR1 and CXCL13 was also observed. The results for efficacy assessed by reduction in disease activity score-28 (DAS-28) and remission assessed by the ACR-EULAR classification show a significant decrease (P < 0.01) after treatment in RA patients.

Conclusion

The significant clinical efficacy response obtained here is likely to be related to a significant reduction of IL-6 and ESR suggesting the role of Qurs-e-Hudar through IL-6 pathway. Larger systematic and comparative trials are warranted for further evaluation.

一种被称为Qurs-e-Hudar的草药配方用于治疗类风湿关节炎（RA），尚无已知的作用机制。在这项研究中，我们评估了Qurs-e-Hudar对RA患者血清生物标志物的影响。方法在一项开放标签、单中心临床研究中，26例RA患者接受Qurs-e-Hudar治疗，剂量为250 mg，每天2次，为期6周。定量评价RA患者和26名健康受试者治疗前后血清生物标志物，包括类风湿因子（RF）、抗环氨酸肽（anti-CCP）、红细胞沉降率（ESR）、c反应蛋白（CRP）、肿瘤坏死因子受体1 （TNFR1）、血管细胞粘附分子1 （VCAM1）、白细胞介素6 （IL-6）和趋化因子配体13 （CXCL13）。结果ESR、CRP、TNFR1、IL-6、CXCL13均显著升高(P <；0.05)。(P <；0.05)对RA患者治疗后ESR和IL-6值的影响。虽然不显著，但也观察到TNFR1和CXCL13的减少。以疾病活动性评分-28 （DAS-28）降低评估的疗效和以ACR-EULAR分级评估的缓解的结果显示显著降低(P <；0.01)。结论本研究获得的显著临床疗效反应可能与显著降低IL-6和ESR有关，提示Qurs-e-Hudar通过IL-6通路发挥作用。有必要进行更大规模的系统和比较试验以进一步评价。

{"title":"Serum biomarkers in rheumatoid arthritis patients and effect of Unani herbal formulation Qurs-e-Hudar on these biomarkers suggesting the anti-IL-6 effect","authors":"Towseef Amin Rafeeqi , Riyaz Ahmed Pandith , Humma , Arjumand Shah , Mohammad Zakir , Nighat Anjum , Irfat Ara , N. Zaheer Ahmed","doi":"10.1016/j.hermed.2025.100999","DOIUrl":"10.1016/j.hermed.2025.100999","url":null,"abstract":"<div><h3>Introduction</h3><div>One of the herbal formulations known as Qurs-e-Hudar used in the Unani medicine for the treatment of rheumatoid arthritis (RA), has no known mechanism of action. In this endeavour, the effect of Qurs-e-Hudar on serum biomarkers in RA patients was evaluated.</div></div><div><h3>Methods</h3><div>In an open-label, single-centric clinical study, 26 RA patients were assessed for 6-week treatment by Qurs-e-Hudar in a dose of 250 mg twice a day. The serum was evaluated quantitatively for biomarkers including rheumatoid factor (RF), anti–cyclic citrullinated peptide (anti-CCP), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), tumour necrosis factor receptor 1 (TNFR1), vascular cell adhesion molecule 1 (VCAM1), interleukin 6 (IL-6), and chemokine ligand 13 (CXCL13) before and after treatment in RA patients and 26 healthy participants at once.</div></div><div><h3>Results</h3><div>The ESR, CRP, TNFR1, IL-6 and CXCL13 values were significantly high (<em>P</em> < 0.05) in RA patients comparing healthy controls. There was a significant reduction in (<em>P</em> < 0.05) in ESR and IL-6 values after treatment in RA patients. Although non-significant, a reduction in TNFR1 and CXCL13 was also observed. The results for efficacy assessed by reduction in disease activity score-28 (DAS-28) and remission assessed by the ACR-EULAR classification show a significant decrease (P < 0.01) after treatment in RA patients.</div></div><div><h3>Conclusion</h3><div>The significant clinical efficacy response obtained here is likely to be related to a significant reduction of IL-6 and ESR suggesting the role of Qurs-e-Hudar through IL-6 pathway. Larger systematic and comparative trials are warranted for further evaluation.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"50 ","pages":"Article 100999"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0