Journal of Herbal Medicine最新文献_第9页

Aloe vera Alters Periostin Expression, Abolishes EMT Phenotype, and Sensitises Cells to Radiation in Conjunction With Atorvastatin in Cervical Cancer 芦荟与阿托伐他汀联用可改变宫颈癌细胞的骨膜增生蛋白表达、消除 EMT 表型并使细胞对辐射敏感

IF 2.3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-04-30 DOI: 10.1016/j.hermed.2024.100873

P. Thomas , S. Sahoo , S. Mahajan , D.L. Hiremath , A.H. Udayashankara , S. Srivastava

Introduction

Resistance to chemoradiation therapy results in poor prognosis and relapse in a sizeable percentage of cervical cancer patients. Toxicities and long-term side effects associated with radiation also warrant the need for molecules that could sensitise cells to radiation therapy. Naturally-derived compounds are a reservoir of non-toxic, potentially effective radiosensitizers of therapy-resistant tumours. This study evaluates the antitumorigenic properties of Aloe vera extracts.

Methods

Phenotypic assays and biochemical experiments like flow cytometry, real-time quantitative PCR, immunofluorescent imaging, western blotting, migration, and wound-healing assays were used to determine the effect of Aloe vera on cervical cancer cell lines.

Results

While Aloe vera treatment caused no significant changes to proliferation, survival, and cell cycling profiles, the expression of periostin, a molecule known for its association with stem-like cancer cells, decreased significantly. Phenotypically, Aloe vera treatment led to diminished clonogenicity and migratory abilities. Finally, combinatorial treatment of cells with Aloe vera and atorvastatin (a pan-Rho GTPase inhibitor) before radiation therapy resulted in a marked decrease in cell survival.

Conclusions

Our findings prove that Aloe vera treatment leads to reduced expression of periostin and adversely affects self-renewal and migration. Importantly, this work provides evidence that Aloe vera, in combination with atorvastatin, could serve as potential radiosensitizers of cancer cells.

导言对化学放疗的耐药性导致预后不良，相当比例的宫颈癌患者会复发。与放射治疗相关的毒性和长期副作用也使得人们需要能使细胞对放射治疗敏感的分子。天然萃取的化合物是一种无毒、可能有效的抗肿瘤放射增敏剂。本研究评估了芦荟提取物的抗肿瘤特性。方法采用表型测定和生化实验，如流式细胞术、实时定量 PCR、免疫荧光成像、Western 印迹、迁移和伤口愈合实验，来确定芦荟对宫颈癌细胞株的影响。结果虽然芦荟处理对细胞的增殖、存活和细胞周期特征没有造成显著变化，但因与干样癌细胞相关而闻名的分子--骨膜蛋白的表达却显著下降。从表型上看，芦荟处理导致克隆生成和迁移能力减弱。最后，在放疗前用芦荟和阿托伐他汀（一种泛Rho GTP酶抑制剂）联合处理细胞，会导致细胞存活率明显下降。重要的是，这项工作提供了芦荟与阿托伐他汀联用可作为潜在的癌细胞放射增敏剂的证据。

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引用次数: 0

The effectiveness of common household spices and herbs in combating the COVID-19: a review based on experimental and virtual screening 家庭常用香料和草药对抗 COVID-19 的功效：基于实验和虚拟筛选的综述

IF 2.3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-04-26 DOI: 10.1016/j.hermed.2024.100887

Aisha Saddiqa , Usman Shazad , Sundas Arshad

Introduction

As of December 2019, the seventh coronavirus strain (SARS-COV-2), also known as COVID-19, had erupted in Wuhan, China, causing a global pandemic. This virus, which has also caused over 6.9 million deaths, has infected over 700 million people globally. Alternative preventive and therapeutic strategies, such as medicinal botanicals, are being sought in response to the COVID-19 pandemic.

Methods

The combination of common herbal components with antiviral action, confirmed experimentally and computationally, is the subject of this review paper. We compiled a list of one hundred antiviral phytochemicals from Aloe vera, honey, cinnamon, garlic, ginger, clove, and black cumin seeds from the literature. These compounds targeted three important steps in the replication cycle of SARS-CoV-2: the spike protein, RdRp, ACE2, NSP-16, and main protease (MPro). The phytochemical’s anti-viral potential is determined by their binding energy levels.

Results

Many herbs and spices contain bioactive phytochemicals that have shown strong binding energies to inhibit various targets of the SARS-CoV-2 protein. The development of antiviral medications to treat SARS-CoV-2 could be aided by further clinical trials on these molecules.

Conclusions

According to the findings of the literature study, it was concluded that the phytochemicals that are found in common household herbs and spices have the potential to play a significant role in the prevention and treatment of coronavirus transmission.

导言截至 2019 年 12 月，第七株冠状病毒（SARS-COV-2）（又称 COVID-19）在中国武汉爆发，引发全球大流行。这一病毒也已造成 690 多万人死亡，全球已有 7 亿多人感染。本综述论文的主题是通过实验和计算证实的具有抗病毒作用的常见草药成分组合。我们从文献中整理出了来自芦荟、蜂蜜、肉桂、大蒜、生姜、丁香和黑孜然种子的 100 种抗病毒植物化学物质。这些化合物针对 SARS-CoV-2 复制周期中的三个重要步骤：尖峰蛋白 RdRp、ACE2、NSP-16 和主蛋白酶（MPro）。结果许多草药和香料都含有生物活性植物化学物质，它们具有很强的结合能，能抑制 SARS-CoV-2 蛋白的不同靶点。结论根据文献研究的结果，可以得出结论，家庭常用草药和香料中的植物化学物质有可能在预防和治疗冠状病毒传播方面发挥重要作用。

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引用次数: 0

Effect of chewing gum containing Zingiber officinale on dry mouth condition in haemodialysis patients compared to chewing gum without Zingiber officinale 与不含细辛的口香糖相比，含细辛的口香糖对血液透析患者口干的影响

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-04-26 DOI: 10.1016/j.hermed.2024.100872

Sara Pourshahidi , Soheila Manifar , Fatemeh Dadashi , Ahmad R. Shamshiri , Mahboob L. Pezeshki , Faraz Mojab

Introduction

Xerostomia is the most common presentation of salivary glands dysfunction affecting about 20% of the population. This study investigated the effect of ginger gum on xerostomia and quality of life in haemodialysis patients.

Methods

Thirty patients undergoing haemodialysis with dry mouth were randomly divided to ginger and placebo gum groups. At the beginning of the study, unstimulated and stimulated saliva samples were collected and Xerostomia Inventory (XI) and Oral Health Impact Profile (OHIP-Per14) questionnaires were administered. After 14 days, stimulated and unstimulated saliva samples were collected again and XI and OHIP-Per14 questionnaires were completed. Analysis of covariance was applied for statistical analysis.

Results

The rate of unstimulated salivary flow (P = 0.03) and oral health related quality of life (P = 0.03) were significantly higher in patients that received ginger chewing gum. The amount of stimulated saliva (P = 0.10) and the mean severity of dry mouth (P = 0.19) were higher in patients receiving ginger gum compared to the placebo group, but the difference was not statistically significant.

Conclusion

With regard to the effect of ginger gum on increasing unstimulated saliva and quality of life, it can be proposed as a safe, inexpensive, and available method to manage dry mouth.

导言：口干是唾液腺功能障碍最常见的表现形式，约占总人口的 20%。本研究调查了生姜口香糖对血液透析患者口干症和生活质量的影响。研究开始时，收集非刺激性和刺激性唾液样本，并进行口干症量表（XI）和口腔健康影响档案（OHIP-Per14）问卷调查。14 天后，再次收集受刺激和未受刺激的唾液样本，并填写 XI 和 OHIP-Per14 问卷。结果接受生姜口香糖治疗的患者的非刺激性唾液流量（P = 0.03）和口腔健康相关生活质量（P = 0.03）均明显高于接受生姜口香糖治疗的患者。接受生姜口香糖治疗的患者与安慰剂组相比，刺激唾液量（P = 0.10）和口干的平均严重程度（P = 0.19）更高，但差异无统计学意义。

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引用次数: 0

Peltophorum (Caesalpinioideae, Fabaceae): a review on ethnobotanical, pharmacological and phytochemical profiles Peltophorum（Caesalpinioideae，Fabaceae）：人种植物学、药理学和植物化学概况综述

IF 2.3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-04-26 DOI: 10.1016/j.hermed.2024.100883

Lucía S. Di Ciaccio , Alejandra V. Catalano , Paula G. López , Renée H. Fortunato , Adriana E. Salvat

Introduction

Seven species of three are recognised in the genus Peltophorum, distributed in the tropics and subtropics of America, South Africa, Asia, and Oceania. These species are used as ornamentals, restorers of degraded ecosystems, and forestry, providing commercially valuable wood. This review aims to analyse the different records of biological activity reported for the genus.

Methods

Bibliographic searches were conducted across various recognised databases, including Google Scholar, PubMed, Scopus, ScienceDirect, and Portal da Periódicos da CAPES. The searches encompassed articles, research theses, and books specifically addressing ethnobotany, isolated chemical constituents, and bioactivities within Peltophorum species. The exploration covered the years 1982–2023, and the connectors 'and' and 'or' were used.

Results

The total number of articles on the genus Peltophorum evaluated was 85, with seven excluded based on the editor's requirements and the nature of the research. This study comprehensively investigated the seven taxonomically recognised species, documenting the activities of synonyms and updating their nomenclatural binomials under the International Plant Names Index (IPNI). The review considered the diverse biological activities associated with these species, encompassing antiparasitic, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, antioxidant, antimutagenic, and traditional medicinal uses such as analgesic, hepatoprotective, and cardioprotective effects, among others. Analysis of phytochemical groups linked to different bioactivities revealed a predominance of phenolic compounds, coumarins, flavonoids, saponins, and tannins.

Conclusions

A detailed review of the Peltophorum genus was presented, inclusive of the phytochemical background, as well as various pharmacological and ethnobotanical activities. This contribution provides valuable information for future research.

导言Peltophorum属有7种3个种，分布在美洲、南非、亚洲和大洋洲的热带和亚热带地区。这些物种被用作观赏植物、退化生态系统的恢复者和林业，提供有商业价值的木材。本综述旨在分析有关该属生物活动的不同记录。方法在各种公认的数据库中进行文献检索，包括 Google Scholar、PubMed、Scopus、ScienceDirect 和 Portal da Periódicos da CAPES。搜索范围包括专门针对黄柏物种的人种植物学、分离化学成分和生物活性的文章、研究论文和书籍。检索时间为 1982-2023 年，使用了连接词 "和 "和 "或"。结果共评估了 85 篇关于 Peltophorum 属的文章，根据编辑要求和研究性质排除了 7 篇。本研究全面调查了分类学上已确认的七个物种，记录了同义词的活动，并根据国际植物名称索引（IPNI）更新了它们的命名双名。综述考虑了与这些物种相关的多种生物活性，包括抗寄生虫、抗菌、抗真菌、抗病毒、抗癌、抗炎、抗氧化、抗突变以及传统医学用途，如镇痛、保肝和保护心脏等作用。对与不同生物活性相关的植物化学组的分析表明，酚类化合物、香豆素、黄酮类化合物、皂苷和单宁酸占主导地位。这为今后的研究提供了宝贵的信息。

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引用次数: 0

The Effect of Mentha spicata Essential Oil (Supermint Oral Drops) on Gastric Residual Volume in Mechanically Ventilated Intensive Care Unit Patients: A Parallel-Group, Triple-Blinded, Randomised, Placebo-Controlled Trial 薄荷精油（超级薄荷口服滴剂）对机械通气重症监护室患者胃剩余容积的影响：平行组、三重盲、随机、安慰剂对照试验

IF 2.3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-04-25 DOI: 10.1016/j.hermed.2024.100886

F. Mohammadzadeh , S.S. Bilondi , M. Sahebanmaleki , J. Asari–Sani-Mend , M. Tavakolizadeh , H. Aalami , A. Delshad Noghabi

Introduction

Delayed gastric emptying is a prevalent problem in intensive care unit (ICU) patients on mechanical ventilation receiving enteral nutrition. This study aimed to assess the effect of Mentha spicata essential oil (Supermint oral drops) on gastric residual volume (GRV) in this patient population.

Methods

In this clinical trial study, from May 1, 2020 to January 30, 2021, 60 mechanically ventilated ICU patients were randomly assigned to intervention and control groups. From the first day of their feeding, patients in the intervention and control groups, respectively, received 20 drops of the Supermint and placebo dissolved in 40 ml of water, three times daily for 4 days. The GRV was measured at the baseline and during four days of intervention. Data were analysed using a generalised estimation equation regression model.

Results

Of the patients, 58.1% were female. The mean age of patients was 71.5 (SD = 14.2), and 65.5% were hospitalised for coronavirus disease 2019. The results indicated no significant difference between the two groups in terms of the baseline GRV (P = 0.181). There was a significant interaction between time and the treatment group (P < 0.001), which suggested that GRV changes over time were different between the two groups. In the control group, the average GRV increased by 0.07 for each unit increase in time, while in the Supermint group, it decreased significantly by 1.09.

Conclusions

The current study’s finding suggested that M spicata essential oil may have the potential to reduce GRV in ICU patients undergoing mechanical ventilation. Further studies are needed to confirm this finding.

IRCT code

No: IRCT20191223045868N1. Date: March 28, 2020. Available at: http://irct.ir/trial/46580.

导言胃排空延迟是重症监护病房（ICU）接受肠内营养的机械通气患者普遍存在的问题。本研究旨在评估薄荷精油（Supermint口服滴剂）对该患者群体胃剩余容积（GRV）的影响。方法在这项临床试验研究中，从 2020 年 5 月 1 日至 2021 年 1 月 30 日，60 名接受机械通气的 ICU 患者被随机分配到干预组和对照组。从喂食的第一天起，干预组和对照组的患者分别服用 20 滴溶于 40 毫升水中的 Supermint 和安慰剂，每天三次，连续服用 4 天。在基线和四天的干预期间测量 GRV。数据采用广义估计方程回归模型进行分析。患者的平均年龄为71.5岁（SD = 14.2），65.5%的患者因冠状病毒病住院治疗。结果显示，两组患者的基线 GRV 无明显差异（P = 0.181）。时间与治疗组之间存在明显的交互作用（P <0.001），这表明两组的 GRV 随时间的变化有所不同。在对照组中，时间每增加一个单位，GRV 平均值就会增加 0.07，而在 Supermint 组中，GRV 平均值则会明显下降 1.09。还需要进一步的研究来证实这一发现。日期：2020 年 3 月 28 日2020年3月28日。网址：http://irct.ir/trial/46580。

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引用次数: 0

The impact of sesame oil on postpartum after-pain in multiparous women: a randomised, triple-blind, placebo-controlled clinical trial 芝麻油对多产妇产后疼痛的影响：随机、三联盲、安慰剂对照临床试验

IF 2.3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-04-23 DOI: 10.1016/j.hermed.2024.100885

Mahdis Mehrabi Bardar , Fatemeh Zahra Karimi , Seyed Reza Mazloum , Roshanak Salari

Introduction

This study aimed to evaluate the impact of sesame oil soft gels on postpartum pain in multiparous women.

Methods

A total of 86 multiparous women participated in a randomised, triple-blind, placebo-controlled trial. The women received a 1.1-g capsule of sesame oil or placebo after vaginal delivery every 6 hours for 24 hours. After-pain was assessed using a pain-o-meter 1 hour after each dose of medication or placebo.

Results

After the intervention, the mean scores of pain intensity (P < 0.001), emotional pain (P < 0.001), physical pain (P < 0.001) and total pain (P < 0.001) in the group that received sesame oil soft gels were significantly lower than those in the placebo group.

Conclusion

Sesame oil soft gels are affordable, easily available and they have been shown to decrease the severity of after-pains in multiparous women that would reduce the necessity of chemical drugs usage which have various side effects.

方法共有 86 名多产妇参加了一项随机、三重盲法、安慰剂对照试验。这些产妇在阴道分娩后每 6 小时服用一粒 1.1 克的芝麻油胶囊或安慰剂，连续服用 24 小时。结果干预后，接受芝麻油治疗组的疼痛强度（P< 0.001）、情感疼痛（P< 0.001）、身体疼痛（P< 0.001）和总疼痛（P< 0.结论芝麻油软胶囊价格低廉、易于获得，而且已被证明可降低多产妇产后疼痛的严重程度，从而减少使用具有各种副作用的化学药物的必要性。

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引用次数: 0

Mechanistic Insight Into Anti-inflammatory Potential of Hibiscus rosa-sinensis Flower Extract as a Herbal Remedy: A Systematic Review 芙蓉花提取物作为草药的抗炎潜力机理透视：微型综述

IF 2.3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-04-21 DOI: 10.1016/j.hermed.2024.100884

J.R. Geeganage , M.D.T.L. Gunathilaka

Introduction

Inflammation is a biological response of the immune system to noxious stimuli. Typically, non-steroidal anti-inflammatory drugs are used to treat inflammatory diseases but have several adverse effects. Therefore, it is important to search for natural plant-based remedies to treat inflammatory conditions. Hibiscus rosa-sinensis is a flowering plant belonging to the genus Hibiscus, which is widely used as a home remedy in Sri Lanka.

Methods

The information was collected via major scientific databases including PubMed, ScienceDirect, Google Scholar, and Springer related to the H rosa-sinensis species, polyphenols, chemical composition, and how the flower extract shows anti-inflammatory potential. Collected data were then analysed and interpreted.

Results

The flower H rosa-sinensis is a rich source of polyphenolic compounds including flavonoids and non-flavonoids, tannins, alkaloids, glycosides, saponins, terpenoids, vitamins, and other organic acids, which are reported to exhibit antioxidant and anti-inflammatory potential. The anti-inflammatory activity of H rosa-sinensis flower is expressed via several mechanisms including the reduction of oxidative stress, inhibition of nuclear factor kappa-B and mitogen-activated protein kinase pathways, and the alterations of the arachidonic acid pathway. In addition, the inhibition of inducible nitric oxide synthase enzyme and caspase activity and reduction of polymorphonuclear leucocyte infiltration can be given as other mechanisms.

Conclusions

H rosa-sinensis flower is a rich source of bioactive compounds that exhibit potent antioxidant and anti-inflammatory activities.

导言炎症是免疫系统对有害刺激的一种生物反应。非甾体类消炎药通常用于治疗炎症性疾病，但会产生一些不良反应。因此，寻找治疗炎症的天然植物疗法非常重要。方法通过主要科学数据库（包括 PubMed、ScienceDirect、Google Scholar 和 Springer）收集有关 H rosa-sinensis 品种、多酚、化学成分以及花提取物如何显示抗炎潜力的信息。然后对收集到的数据进行分析和解释。结果玫瑰花含有丰富的多酚化合物，包括黄酮类和非黄酮类化合物、单宁、生物碱、苷类、皂苷、萜类化合物、维生素和其他有机酸，据报道这些化合物具有抗氧化和消炎的潜力。玫瑰金雀花的抗炎活性通过几种机制表现出来，包括减少氧化应激、抑制核因子卡巴-B 和丝裂原活化蛋白激酶途径，以及改变花生四烯酸途径。此外，其他机制还包括抑制诱导型一氧化氮合酶酶和 Caspase 活性以及减少多形核白细胞浸润。

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引用次数: 0

Capsaicin Ameliorates Chemotherapy Response via Cancer Hallmarks Modulation: An Overview of its Synergic Potential 辣椒素通过调节癌症标志改善化疗反应：综述其协同潜力

IF 2.3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-04-20 DOI: 10.1016/j.hermed.2024.100882

R.F. Costa , F.C. Cadoná

Introduction

Cancer is a disease caused by genetic changes and disordered cell growth with high incidences over the years. Conventional treatments such as chemotherapy act on cells that are in constant cell division; however, frequently, they are not selective to cancer cells and can damage healthy cells. For this reason, side effects such as nausea, dizziness, hair loss, weight loss, and fatigue are reported by patients. Moreover, some cancers present resistance to chemotherapy treatment. Therefore, studies focusing on functional and natural products, especially those rich in bioactive compounds, such as capsaicin, could be used as chemotherapy adjuvant to improve treatment response and decrease side effects.

Methods

In this scenario, we conducted a review of 75 articles regarding the anticancer activity and chemotherapy response improvement of capsaicin via cancer hallmark modulation.

Results

In this scenario, we reviewed the anticancer activity and chemotherapy response improvement of capsaicin via cancer hallmark modulation. This natural bioactive molecule ameliorates the chemotherapy response by several cancer pathway regulations.

Conclusions

This review was able to show that capsaicin has a remarkable effect as an adjuvant to improve chemotherapy and reduce side effects.

导言癌症是一种由基因变化和细胞生长紊乱引起的疾病，多年来发病率居高不下。化疗等传统疗法作用于不断分裂的细胞，但往往对癌细胞没有选择性，反而会损害健康细胞。因此，患者会出现恶心、头晕、脱发、体重减轻和疲劳等副作用。此外，有些癌症对化疗具有抗药性。因此，研究重点应放在功能性天然产品上，尤其是那些富含生物活性化合物的产品，如辣椒素，可用作化疗辅助药物，以改善治疗反应并减少副作用。结果在本方案中，我们综述了辣椒素通过调节癌症标志物来改善抗癌活性和化疗反应的 75 篇文章。结论本综述表明，辣椒素作为一种辅助药物，在改善化疗和减少副作用方面具有显著效果。

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引用次数: 0

Astragalus Mongholicus: A Review of its Pharmacological Mechanisms Against Gastric Cancer 黄芪：黄芪抗胃癌药理机制综述

IF 2.3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-04-16 DOI: 10.1016/j.hermed.2024.100881

J.J. Tibenda , Y. Du , Y. Nan , S. Huang , G. Chen , N. Ning , X. Li , Y. Yang , L. Yuan

Introduction

Astragalus membranaceus (AM) is an outstanding traditional medicinal herb that has been highly utilised for many decades in China, mainly as an adaptogen. Several medicinal functions have been associated with the components of astragalus, such as antitumour, anti-inflammatory, immune-enhancing, antioxidative, neuroprotective, and cardioprotective functions. In addition to providing future ideas on the pharmacological effects of AM in the treatment of gastric cancer (GC), this review aims to elucidate the active components of AM and its antitumour effects in GC, as well as highlight the existing experimental studies on the mechanism of AM in GC.

Methods

Literature publications relevant to the aim of the study were screened from Science Direct, PubMed, Web of Science, and Google Scholar. ‘Astragalus mongholicus,’ ‘Astragalus mongholicus, Gastric Cancer,’ ‘Astragalus Polysaccharides, Gastric Cancer,’ ‘Astragalus Saponins, Gastric Cancer,’ and ‘Flavonoids of Astragalus’ were the key terms used.

Results

Studies showed that the mechanism of action of AM in GC mainly includes suppression of cellular migration, proliferation, and invasion of GC cells. Furthermore, AM promotes cell cycle arrest and apoptosis by regulating several intracellular signalling pathways involved mainly in the immune system and inflammation.

Conclusions

The main active ingredients of AM, such as Astragalus polysaccharide, Astragaloside IV, and flavonoids like calycosin, play a major role in attenuating GC. The compounds were found to possess potent antitumour effects against GC and have to be further evaluated. Astragalus membranaceus is also a potential adjuvant chemotherapy agent.

导言黄芪（AM）是一种优秀的传统药材，几十年来在中国一直被广泛利用，主要作为一种适应原。黄芪的成分具有多种药用功能，如抗肿瘤、抗炎、免疫增强、抗氧化、神经保护和心脏保护功能。本综述旨在阐明黄芪的活性成分及其在胃癌中的抗肿瘤作用，并重点介绍现有关于黄芪在胃癌中的作用机制的实验研究，同时为黄芪在胃癌治疗中的药理作用提供未来思路。结果研究表明，AM对GC的作用机制主要包括抑制GC细胞的迁移、增殖和侵袭。结论 AM 的主要活性成分，如黄芪多糖、黄芪皂苷 IV 和黄酮类化合物（如钙黄苷），在减轻 GC 方面发挥了重要作用。研究发现，这些化合物对 GC 具有很强的抗肿瘤作用，有待进一步评估。膜荚黄芪还是一种潜在的辅助化疗药物。

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引用次数: 0

A systematic study on herbal cream for various clinical and therapeutic application: current status and future prospects 关于各种临床和治疗用草药膏的系统研究：现状与前景

IF 2.3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-04-04 DOI: 10.1016/j.hermed.2024.100880

Arushi, Ashok Behera, Neeraj K. Sethiya, Satish Shilpi

Introduction

Recent trends and current market analysis suggest demand for herbal formulations, including herbal creams, is increasing over synthetic creams due to their lower toxicity and fewer side effects, followed by more skin nourishment capability, according to several published studies. Moreover, published literature lacks any updated, compiled explanatory review on herbal creams. Therefore, we designed the present communication to accomplish the current requirement.

Objective

The major objective of the present communication is to provide the clinical data-based evidence and state of the art adopted for the formulation and development of herbal cream, including its composition and manufacturing processes, to establish therapeutic effectiveness.

Method

Both online and offline literature searches were performed and screened. The publications accounted for in vitro and clinical studies, followed by various preparation methods, classification and manufacturing process were included. There were a total of 150 papers finally selected and reviewed in the present communications addressing concerns related to herbal cream from 1995 to July 2023.

Result

It was established that herbal creams can be produced using a variety of techniques and methods. Majorly anti-inflammatory, dermatitis, anti-trauma, anti-aging, anti-acne, and vulvovaginal herbal creams were enlisted in terms of different clinical and therapeutic application.

Conclusion

The evidence from the present systematic review suggests that more human clinical trials with larger sample sizes are needed in order to achieve higher accuracy in terms of the safety and efficacy of herbal creams.

导言：最近的趋势和当前的市场分析表明，与合成面霜相比，草药配方（包括草药面霜）的需求正在增加，原因是其毒性较低，副作用较少，而且具有更强的皮肤滋养能力。此外，已发表的文献中缺乏关于草本面霜的最新解释性综述。本报告的主要目的是提供基于临床数据的证据以及草药面霜配方和开发所采用的技术水平，包括其成分和生产工艺，以确定其治疗效果。包括体外和临床研究，以及各种制备方法、分类和生产工艺。本研究最终选取了 150 篇论文，并对 1995 年至 2023 年 7 月期间与草本药膏相关的问题进行了综述。结论本系统综述的证据表明，需要进行更多样本量更大的人体临床试验，以提高草药乳膏安全性和有效性的准确性。

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