Pub Date : 2022-08-26DOI: 10.2174/2210315512666220826145928
K. Kumar, Sheetu, Arun Sharma, Gurvinder Singh, Rajesh Kumar
Carbohydrates are the most common biopolymers, with the capability to construct supramolecular structures. For biomedical purposes, a variety of carbohydrate-based nanoparticles have been used. Basic monosaccharides or disaccharides, along with sophisticated polymeric systems, are used to create these structures. The shape and properties of these materials can be modified using chemical alterations. Carbohydrates-based nanogels and nanoparticles have been used for drug delivery, tissue engineering, and cell imaging. Carbohydrate-based elements are excellent derivatives for the production of responsive systems because of the reversible character of the assembly, which is frequently based on a mixture of hydrophobic interactions and hydrogen bonding. The present manuscript attempts to review the recent studies on carbohydrate-based nanomaterials and an update on the patents granted for the same.
{"title":"Natural Carbohydrates-based Nanoparticles: A Review of Pharmaceutical Applications","authors":"K. Kumar, Sheetu, Arun Sharma, Gurvinder Singh, Rajesh Kumar","doi":"10.2174/2210315512666220826145928","DOIUrl":"https://doi.org/10.2174/2210315512666220826145928","url":null,"abstract":"\u0000\u0000Carbohydrates are the most common biopolymers, with the capability to construct supramolecular structures. For biomedical purposes, a variety of carbohydrate-based nanoparticles have been used. Basic monosaccharides or disaccharides, along with sophisticated polymeric systems, are used to create these structures. The shape and properties of these materials can be modified using chemical alterations. Carbohydrates-based nanogels and nanoparticles have been used for drug delivery, tissue engineering, and cell imaging. Carbohydrate-based elements are excellent derivatives for the production of responsive systems because of the reversible character of the assembly, which is frequently based on a mixture of hydrophobic interactions and hydrogen bonding. The present manuscript attempts to review the recent studies on carbohydrate-based nanomaterials and an update on the patents granted for the same.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46562924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.2174/2210315512666220819112334
Mayank Kumar Malik, Pankaj Bhatt, T. Kumar, Jaspal Singh, Vipin Kumar, A. Faruk, S. Fuloria, N. Fuloria, Vetriselvan Subrimanyan, Sunil Kumar
Delivery of therapeutics using synthetic polymers is challenging due to toxicity, immunogenicity and impaired bioavailability following administration. However, natural polymers are being explored as safe for their use as a substitute for synthetic polymers. In the past three decades, the biomaterials like starches have been applied to impart an imperative role in delivering therapeutics. Resultantly, there is an increased focus on finding new sources of starches along with their modifications. Hence, derivatization of starches has become a necessity to achieve desired properties. The modifications to native starch systems are being investigated to improve solubility, stability, bioavailability, etc. of an incorporated drug (s) and lower-down induced toxicities. All these requirements have led to the use of modified starches in the drug delivery of bioactive component(s). This review explores the current state of knowledge about starch structure and chemical modification methods in perspectives. It integrates aspects of its use in developing drug delivery devices in the form of tablets, hydrogel, patches. The information provided in this review may be applied as a reference for future chemically modified starch as excipients in drug carrier studies.
{"title":"Significance of chemically derivatized starch as drug carrier in developing novel drug delivery devices","authors":"Mayank Kumar Malik, Pankaj Bhatt, T. Kumar, Jaspal Singh, Vipin Kumar, A. Faruk, S. Fuloria, N. Fuloria, Vetriselvan Subrimanyan, Sunil Kumar","doi":"10.2174/2210315512666220819112334","DOIUrl":"https://doi.org/10.2174/2210315512666220819112334","url":null,"abstract":"\u0000\u0000Delivery of therapeutics using synthetic polymers is challenging due to toxicity, immunogenicity and impaired bioavailability following administration. However, natural polymers are being explored as safe for their use as a substitute for synthetic polymers. In the past three decades, the biomaterials like starches have been applied to impart an imperative role in delivering therapeutics. Resultantly, there is an increased focus on finding new sources of starches along with their modifications. Hence, derivatization of starches has become a necessity to achieve desired properties. The modifications to native starch systems are being investigated to improve solubility, stability, bioavailability, etc. of an incorporated drug (s) and lower-down induced toxicities. All these requirements have led to the use of modified starches in the drug delivery of bioactive component(s). This review explores the current state of knowledge about starch structure and chemical modification methods in perspectives. It integrates aspects of its use in developing drug delivery devices in the form of tablets, hydrogel, patches. The information provided in this review may be applied as a reference for future chemically modified starch as excipients in drug carrier studies.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42053115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-11DOI: 10.2174/2210315512666220811153919
Vanktesh Kumar, Navjot Kaur, A. Kaur, P. Wadhwa
Hyssopus officinalis is a traditional medicinal plant that belongs to the family Lamiaceae, which has been used from centuries for various purposes like carminative, expectorant, cough reliever. It has been used for the treatment of numerous diseases in patients such as ulcers, asthma, jaundice, leprosy, dropsy, bronchitis, COPD, diabetes, AIDS, bacterial and fungal infections as an herbal remedy due to its fewer side effects and is more efficacies than other traditional medicine. Major classes of chemical compounds found in H. officinalis essential oil are bicyclic monoterpenes, monoterpenoids, acyclic monoterpenes, phenolic monoterpenoids, monocyclic monoterpenes, monocyclic sesquiterpenes, tricyclic sesquiterpenes, bicyclic sesquiterpenes, tricyclic sesquiterpenoids, straight chain saturated hydrocarbons. Some of the major chemical constituents present in the H. officinalis are β-pinene, α-pinene, 1, 8-cineole, apigenin, diosmin, caffeic acid, rosmarinic acid, cis-pinocamphone, trans-pinocamphone, iso-pinocamphone, pinocarvone, which are responsible for its various pharmacological activity. Various studies have been performed on the pharmacological activity of its extract, such as antioxidant, antimicrobial, anti-diabetic, anticancer, antiviral, anti-inflammatory, analgesic, anti-leishmanial, anthelmintic, anti-protozoal and anti-anxiety. Recently, it is use as an anticancer agent has been demonstrated by studying its cytotoxic and apoptotic effects on breast cancer and colon cancer cells. It is used as a potent antibacterial and antifungal agent was studied on the antibiotic-resistant bacterial and fungal strains recently, which can be further useful in developing herbal medicine against AMR. It is an excellent natural antioxidant due to the presence of polyphenolic compounds, and H. officinalis is used in various food industries as a source of natural antioxidants, which has minimum side effects as compared to artificial antioxidants. Furthermore, the pharmacological activity of these individual chemical constituents in H. officinalis extract still needs to be investigated for identifying the effectiveness of this plant in the natural treatment of various diseases. This review aims to collect various data regarding the traditional herbal plant hyssop (Hyssopus Officinalis), including its photochemistry, chemical structures of the phyto-constituents and pharmacological profile, along with all the pharmacological models. This plant has significant importance in the health industry, so further studies are required on its effective usage against various emerging health problems, including COVID-19, cancer, diabetes, AMR.
{"title":"Phytochemistry and Pharmacology of Indian Traditional plant Hyssop (Hyssopus officinalis L.): A Review.","authors":"Vanktesh Kumar, Navjot Kaur, A. Kaur, P. Wadhwa","doi":"10.2174/2210315512666220811153919","DOIUrl":"https://doi.org/10.2174/2210315512666220811153919","url":null,"abstract":"\u0000\u0000Hyssopus officinalis is a traditional medicinal plant that belongs to the family Lamiaceae, which has been used from centuries for various purposes like carminative, expectorant, cough reliever. It has been used for the treatment of numerous diseases in patients such as ulcers, asthma, jaundice, leprosy, dropsy, bronchitis, COPD, diabetes, AIDS, bacterial and fungal infections as an herbal remedy due to its fewer side effects and is more efficacies than other traditional medicine. Major classes of chemical compounds found in H. officinalis essential oil are bicyclic monoterpenes, monoterpenoids, acyclic monoterpenes, phenolic monoterpenoids, monocyclic monoterpenes, monocyclic sesquiterpenes, tricyclic sesquiterpenes, bicyclic sesquiterpenes, tricyclic sesquiterpenoids, straight chain saturated hydrocarbons. Some of the major chemical constituents present in the H. officinalis are β-pinene, α-pinene, 1, 8-cineole, apigenin, diosmin, caffeic acid, rosmarinic acid, cis-pinocamphone, trans-pinocamphone, iso-pinocamphone, pinocarvone, which are responsible for its various pharmacological activity. Various studies have been performed on the pharmacological activity of its extract, such as antioxidant, antimicrobial, anti-diabetic, anticancer, antiviral, anti-inflammatory, analgesic, anti-leishmanial, anthelmintic, anti-protozoal and anti-anxiety. Recently, it is use as an anticancer agent has been demonstrated by studying its cytotoxic and apoptotic effects on breast cancer and colon cancer cells. It is used as a potent antibacterial and antifungal agent was studied on the antibiotic-resistant bacterial and fungal strains recently, which can be further useful in developing herbal medicine against AMR. It is an excellent natural antioxidant due to the presence of polyphenolic compounds, and H. officinalis is used in various food industries as a source of natural antioxidants, which has minimum side effects as compared to artificial antioxidants. Furthermore, the pharmacological activity of these individual chemical constituents in H. officinalis extract still needs to be investigated for identifying the effectiveness of this plant in the natural treatment of various diseases. This review aims to collect various data regarding the traditional herbal plant hyssop (Hyssopus Officinalis), including its photochemistry, chemical structures of the phyto-constituents and pharmacological profile, along with all the pharmacological models. This plant has significant importance in the health industry, so further studies are required on its effective usage against various emerging health problems, including COVID-19, cancer, diabetes, AMR.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48206470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bacteria cause various infectious diseases and cause millions of deaths each year. Bacteria are broadly classified based on the phenotypic and genotypic systems. Bacteria cause resistance mainly by Plasmids, Inactivation of antibiotics, Target site modification, Prevent drug uptake, Efflux pumps, and Biofilm. Plants have been used for thousands of years for their medicinal uses to treat various diseases. Secondary metabolites like terpenes, alkaloids, phenolic compounds, tannins, quinones, steroids, polyketides, aromatics, and, peptides are plant-derived compounds that possess antibacterial activity and decrease resistance by inhibition of biofilm formation, Efflux pump [EP] inhibitors, attenuating bacterial virulence, Immunomodulation activity. Use of phytoconstituents synergism, combination therapy (Bio-enhancers), herbal preparation benefit in antibacterial potential and decrease resistance.
{"title":"A review of phytoconstituents as antibacterial agents","authors":"Gunjan Bisht, Ankit Kumar Singh, Adarsh Kumar, Pradeep Kumar","doi":"10.2174/2210315512666220804111049","DOIUrl":"https://doi.org/10.2174/2210315512666220804111049","url":null,"abstract":"\u0000\u0000Bacteria cause various infectious diseases and cause millions of deaths each year. Bacteria are broadly classified based on the phenotypic and genotypic systems. Bacteria cause resistance mainly by Plasmids, Inactivation of antibiotics, Target site modification, Prevent drug uptake, Efflux pumps, and Biofilm. Plants have been used for thousands of years for their medicinal uses to treat various diseases. Secondary metabolites like terpenes, alkaloids, phenolic compounds, tannins, quinones, steroids, polyketides, aromatics, and, peptides are plant-derived compounds that possess antibacterial activity and decrease resistance by inhibition of biofilm formation, Efflux pump [EP] inhibitors, attenuating bacterial virulence, Immunomodulation activity. Use of phytoconstituents synergism, combination therapy (Bio-enhancers), herbal preparation benefit in antibacterial potential and decrease resistance.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47097095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-03DOI: 10.2174/2210315512666220803164452
Tiong-Keat Goh, Yoon-Yen Yow, Ayaz Anwar, N. Khan, S. Ong
Acanthamoeba is a ubiquitous and parasitic protozoan capable of causing serious human infections, resulting in blindness and even death. Seaweeds are abundant and widely known for their antimicrobial properties. This study aims to unveil the anti-amoebic potential of two Malaysian red seaweeds, Gracilaria changii and Gracilaria salicornia on Acanthamoeba castellanii. Water, methanol and ethyl acetate extracts of G. changii and G. salicornia were tested against A. castellanii. Liquid chromatography-mass spectrometry (LC-MS) analysis was carried out to identify the compounds responsible for the anti-amoebic effect. Methanol extract of G. salicornia showed a significant growth inhibition of 22 % in A. castellanii trophozoites. Cytotoxicity of these extracts were shown to be minimal in human keratinocyte cells through cell viability assay. Data from LC-MS revealed fourteen compounds with reported biological activities. These findings suggest the use of G. changii and G. salicornia as potential sources of anti-amoebic compounds.
{"title":"Novel anti-amoebic properties of agarophytes Gracilaria changii and Gracilaria salicornia extracts","authors":"Tiong-Keat Goh, Yoon-Yen Yow, Ayaz Anwar, N. Khan, S. Ong","doi":"10.2174/2210315512666220803164452","DOIUrl":"https://doi.org/10.2174/2210315512666220803164452","url":null,"abstract":"\u0000\u0000Acanthamoeba is a ubiquitous and parasitic protozoan capable of causing serious human infections, resulting in blindness and even death. Seaweeds are abundant and widely known for their antimicrobial properties. This study aims to unveil the anti-amoebic potential of two Malaysian red seaweeds, Gracilaria changii and Gracilaria salicornia on Acanthamoeba castellanii.\u0000\u0000\u0000\u0000Water, methanol and ethyl acetate extracts of G. changii and G. salicornia were tested against A. castellanii. Liquid chromatography-mass spectrometry (LC-MS) analysis was carried out to identify the compounds responsible for the anti-amoebic effect.\u0000\u0000\u0000\u0000Methanol extract of G. salicornia showed a significant growth inhibition of 22 % in A. castellanii trophozoites. Cytotoxicity of these extracts were shown to be minimal in human keratinocyte cells through cell viability assay.\u0000\u0000\u0000\u0000Data from LC-MS revealed fourteen compounds with reported biological activities. These findings suggest the use of G. changii and G. salicornia as potential sources of anti-amoebic compounds.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47804285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-07DOI: 10.2174/2210315512666220707092403
S. V. Shekade, S. Shirolkar, S. Deshkar, P. S. Giram
Castor oil is a multipurpose vegetable oil extracted from the seeds of the Ricinus communis from the family Euphorbiaceae. The castor oil contains a mixture of esters of saturated and unsaturated fatty acids such as ricinoleic, palmitic, stearic, oleic, linoleic, and linolenic acid linked to glycerol. The unique structure of major constituents of castor oil offers several functionalization possibilities for transforming it into advanced functional material. Although castor oil is considered nonedible, after purification, it is widely used for medicinal and cosmetic purposes. The objective of this paper is to review and compile the research work on the castor oil, its chemicals composition, different methods of extraction with their significance and use of castor oil and its derivatives in healthcare, agriculture, and industrial applications. The literature related to castor oil and its applications was collected through different websites, academic research portals and databases, sorted and presented in this review. Castor oil has been investigated for several medicinal applications including, antiulcer, antimicrobial, bone degeneration, wound healing, and immune-booster etc. Recently, castor oil and its derivatives have been explored as lubricants, bioadhesive, polishing agents, insecticides, fertilizer, in biodiesel production, and as vehicles for various drug delivery systems. This review summarizes the chemical composition of castor oil, various methods for its extraction and purification, castor oil derivatives, and different pharmacological, medicinal, industrial and drug delivery applications. The castor oil and its derivatives offer numerous potential applications in food, pharmaceutical, agricultural and cosmetic industry that has opened up several opportunities of research in this area.
{"title":"Phytochemical, pharmacognostic and pharmacological aspects of Ricinus communis seed oil: An overview","authors":"S. V. Shekade, S. Shirolkar, S. Deshkar, P. S. Giram","doi":"10.2174/2210315512666220707092403","DOIUrl":"https://doi.org/10.2174/2210315512666220707092403","url":null,"abstract":"\u0000\u0000Castor oil is a multipurpose vegetable oil extracted from the seeds of the Ricinus communis from the family Euphorbiaceae. The castor oil contains a mixture of esters of saturated and unsaturated fatty acids such as ricinoleic, palmitic, stearic, oleic, linoleic, and linolenic acid linked to glycerol. The unique structure of major constituents of castor oil offers several functionalization possibilities for transforming it into advanced functional material. Although castor oil is considered nonedible, after purification, it is widely used for medicinal and cosmetic purposes.\u0000\u0000\u0000\u0000The objective of this paper is to review and compile the research work on the castor oil, its chemicals composition, different methods of extraction with their significance and use of castor oil and its derivatives in healthcare, agriculture, and industrial applications.\u0000\u0000\u0000\u0000The literature related to castor oil and its applications was collected through different websites, academic research portals and databases, sorted and presented in this review.\u0000\u0000\u0000\u0000Castor oil has been investigated for several medicinal applications including, antiulcer, antimicrobial, bone degeneration, wound healing, and immune-booster etc. Recently, castor oil and its derivatives have been explored as lubricants, bioadhesive, polishing agents, insecticides, fertilizer, in biodiesel production, and as vehicles for various drug delivery systems. This review summarizes the chemical composition of castor oil, various methods for its extraction and purification, castor oil derivatives, and different pharmacological, medicinal, industrial and drug delivery applications.\u0000\u0000\u0000\u0000The castor oil and its derivatives offer numerous potential applications in food, pharmaceutical, agricultural and cosmetic industry that has opened up several opportunities of research in this area.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46584830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.2174/2210315512666220630105018
Daphisha Marbaniang, A. Das, Paulami Pal, Niva Rani Gogoi, A. Saikia, S. Ray, B. Mazumder
Boswellic acids are series of pentacyclic triterpenes, derived from the gum resin of Boswellia Genus, mostly from Boswellia serrata Roxb. (Burseraceae) tree commonly known as Indian Frankincense or salai guggul and traditionally used as an anti-inflammatory agent. It acts by inhibiting 5-Lipoxygenase, C3-convertase, cyclooxygenase preferably COX-1, Human Leukocyte Elastase, NF-κB expression, Topoisomerase I and II and microsomal Prostaglandin E2 synthase-1. Boswellia species are reported to have various pharmacological potentials like anti-inflammatory, anti-cancer, anti-microbial, anti-arthritic, immunomodulatory activity, neuroprotective activity, and are also proved to be effective against ileitis, ulcerative colitis, hypolipidemic, hypertension and hepatotoxicity. Regardless of their multiple uses, pharmacokinetic studies of Boswellic acids revealed their poor oral bioavailability, high lipophilicity, and their degradation by hepatic Phase I mechanism. With low solubility and poor bioavailability, different approaches have been applied to improve the poor pharmacokinetic profile of Boswellic acids. Designing and developing novel delivery systems for its enhanced permeability, improved bioavailability with better efficacy has been of great interest.
{"title":"Novel delivery technologies: Triggering the Biopharmaceutical potential of Boswellic acids","authors":"Daphisha Marbaniang, A. Das, Paulami Pal, Niva Rani Gogoi, A. Saikia, S. Ray, B. Mazumder","doi":"10.2174/2210315512666220630105018","DOIUrl":"https://doi.org/10.2174/2210315512666220630105018","url":null,"abstract":"\u0000\u0000Boswellic acids are series of pentacyclic triterpenes, derived from the gum resin of Boswellia Genus, mostly from Boswellia serrata Roxb. (Burseraceae) tree commonly known as Indian Frankincense or salai guggul and traditionally used as an anti-inflammatory agent. It acts by inhibiting 5-Lipoxygenase, C3-convertase, cyclooxygenase preferably COX-1, Human Leukocyte Elastase, NF-κB expression, Topoisomerase I and II and microsomal Prostaglandin E2 synthase-1. Boswellia species are reported to have various pharmacological potentials like anti-inflammatory, anti-cancer, anti-microbial, anti-arthritic, immunomodulatory activity, neuroprotective activity, and are also proved to be effective against ileitis, ulcerative colitis, hypolipidemic, hypertension and hepatotoxicity. Regardless of their multiple uses, pharmacokinetic studies of Boswellic acids revealed their poor oral bioavailability, high lipophilicity, and their degradation by hepatic Phase I mechanism. With low solubility and poor bioavailability, different approaches have been applied to improve the poor pharmacokinetic profile of Boswellic acids. Designing and developing novel delivery systems for its enhanced permeability, improved bioavailability with better efficacy has been of great interest.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46295949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-27DOI: 10.2174/2210315512666220627153553
Ashwani K. Dhingra, B. Chopra
Alzheimer’s disease (AD) is an incurable neurodegenerative disorder associated with dementia which leads to the alteration in the psychological and physiological functioning of the individual. From antiquity, medicinal plants serve as important sources of bioactive phytochemicals representing tremendous therapeutic potential. The unavoidable adverse effects associated with synthetic compounds trigger the exploration of new and safer substitutes for the treatment and management of disease conditions. Herbal medication proves to be an emerging and most promising alternative, which is expected to be a revolutionary approach in modern medicine for disease treatment. Several phytochemicals like resveratrol, curcumin, apigenin, docosahexaenoic acid, epigallocatechin gallate, and α-lipoic acid exhibit great potential in the prevention and management of AD. Their use might be a possible remedy and lead to a safe strategy to delay the onset of AD and slow the progression of this pervasive disorder. To determine the potential of these natural components as anti-AD, this review focuses on the updates on clinical studies and research. Extensive literature survey was carried out on natural multitargeted bioactive phytochemicals from various scientific databases like PubMed, Science Direct, Scopus, Clinicaltrails.gov, and many reputed foundations. Current prose emphasizes the identified bioactive compounds as anti-AD, which were reviewed with particular emphasis on their scientific impact and novelty. These compounds diminish the pathophysiological aspects of AD; still, further studies are required to prove the safety and efficacy of these compounds in humans. This present review might help the researchers, academicians and industrialists in drug development as a new paradigm of drug discovery.
{"title":"Neuroprotection of Multitargeted Phytochemicals against Alzheimer: A Desperate Need from Nature","authors":"Ashwani K. Dhingra, B. Chopra","doi":"10.2174/2210315512666220627153553","DOIUrl":"https://doi.org/10.2174/2210315512666220627153553","url":null,"abstract":"\u0000\u0000Alzheimer’s disease (AD) is an incurable neurodegenerative disorder associated with dementia which leads to the alteration in the psychological and physiological functioning of the individual. From antiquity, medicinal plants serve as important sources of bioactive phytochemicals representing tremendous therapeutic potential. The unavoidable adverse effects associated with synthetic compounds trigger the exploration of new and safer substitutes for the treatment and management of disease conditions. Herbal medication proves to be an emerging and most promising alternative, which is expected to be a revolutionary approach in modern medicine for disease treatment.\u0000\u0000\u0000\u0000Several phytochemicals like resveratrol, curcumin, apigenin, docosahexaenoic acid, epigallocatechin gallate, and α-lipoic acid exhibit great potential in the prevention and management of AD. Their use might be a possible remedy and lead to a safe strategy to delay the onset of AD and slow the progression of this pervasive disorder. To determine the potential of these natural components as anti-AD, this review focuses on the updates on clinical studies and research.\u0000\u0000\u0000\u0000Extensive literature survey was carried out on natural multitargeted bioactive phytochemicals from various scientific databases like PubMed, Science Direct, Scopus, Clinicaltrails.gov, and many reputed foundations. Current prose emphasizes the identified bioactive compounds as anti-AD, which were reviewed with particular emphasis on their scientific impact and novelty.\u0000\u0000\u0000\u0000These compounds diminish the pathophysiological aspects of AD; still, further studies are required to prove the safety and efficacy of these compounds in humans.\u0000\u0000\u0000\u0000This present review might help the researchers, academicians and industrialists in drug development as a new paradigm of drug discovery.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49034227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-24DOI: 10.2174/2210315512666220624163105
A. Wal, P. Wal, Neha Verma, A. Rai, Piyush Vatsha
The global distribution of IBS is surprisingly uniform, affecting men and women of all ages. Its deep-rooted character, symptoms that fluctuate from moderate to extreme, have several detrimental effects on the sufferer's standard of living; consequently, proper treatment of these patients is necessary. The etiology of IBS is unknown. Although several explanations were also proposed, the specific etiology of irritable bowel syndrome remains unknown. Clinical trials using stabilized therapies and new active medications have shown symptom reduction over placebo. IBS has long been linked to visceral sensitivity and gastrointestinal motor abnormalities. The pathophysiology of IBS appears to be multifaceted. However, several of the following elements are vital in forming IBS. This paper aims to provide a complete, scientific proof assessment of the prognosis, pathogenesis, and therapy choices to assist clinicians in successfully treating their patients. The report's information was compiled by combining numerous review articles and research papers from multiple sources, including Hindawi, Elsevier, NCBI [National Centre for Biotechnology Information], and Research Gate, from 1981 to 2021, using keywords such as IBS, Brain-gut axis, postinfectious IBS, Microbiota, low-grade inflammation, and so on. The acute symptom influences the selection of medical techniques and therapy (IBS with diarrhoea, IBS with constipation, or mixed IBS). Current research demonstrates both pharmaceutical and non-pharmaceutical treatment has a positive impact (in comparison to a placebo) on irritable bowel syndrome (IBS) problems, discomfort relief, and improved health status.
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