Cancer Epidemiology最新文献

{"title":"Incidence rates and trends of paediatric cancer in Italy, 2008–2017","authors":"Enrica Santelli ,&nbsp;Gemma Gatta ,&nbsp;Fabio Savoia ,&nbsp;Sabrina Fabiano ,&nbsp;Francesco Cuccaro ,&nbsp;Viviana Perotti ,&nbsp;Andrea Tittarelli ,&nbsp;Tiziana Scuderi ,&nbsp;Rosalba Amodio ,&nbsp;Walter Mazzucco ,&nbsp;Fabrizio Stracci ,&nbsp;Ilaria Cozzi ,&nbsp;AIRTUM Working Group","doi":"10.1016/j.canep.2025.102947","DOIUrl":"10.1016/j.canep.2025.102947","url":null,"abstract":"<div><h3>Background</h3><div>Paediatric cancers are rare, yet, Italy has previously shown some of the highest incidence rates in Europe as a leading cause of death in children and adolescents. This study updates data from Italy for 2008–2017, analyses trends from 1998, and compares findings with other European regions.</div></div><div><h3>Methods</h3><div>A population-based approach was used, leveraging data from the Italian Association of Cancer Registries (AIRTUM). Thirty-one cancer registries covering 77 % of the Italian paediatric population contributed data on tumour type, age, sex, residence, and diagnosis date. Cancers were classified using the International Classification of Childhood Cancer, Third Edition (ICCC-3). Age-specific (IR) and age-standardized incidence rates (ASR) were computed, while trends were analysed with Joinpoint regression to estimate annual (APC) and average annual percentage change (AAPC).</div></div><div><h3>Results</h3><div>From 2008–2017, 17,322 malignant paediatric cancer cases were reported in Italy. The age-standardized incidence rate (ASR) was 166.8 per million for ages 0–14 and 294.3 per million for adolescents 15–19. Over the study period, incidence rates were generally stable, but a significant increase was observed for bone tumours in children and thyroid and melanoma in adolescents. Central Italy showed higher incidence rates compared to other Italian regions. Italy still shows one of the highest incidence rates in Europe.</div></div><div><h3>Conclusion</h3><div>While the study confirms overall stable incidence trends in Italy, it also highlights an increase in specific cancers such as melanoma and thyroid tumours in adolescents. Central Italy exhibited higher incidence rates, potentially due to environmental and/or diagnostic factors. Continuous monitoring and further research are needed to clarify regional variations and evaluate the impact of early diagnosis and environmental exposures.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102947"},"PeriodicalIF":2.3,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145362391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of vaccine-induced immunity to hepatitis B in cancer patients: A 13-year analysis in a quaternary oncological center","authors":"Mariana Cavalheiro Magri ,&nbsp;Victória Gonçalves de Paula ,&nbsp;Marina Rossi de Camargo Pinto ,&nbsp;Débora Bignotto Rosane Battaglia ,&nbsp;Rafael de Oliveira ,&nbsp;Gustavo Manoel Ferreira ,&nbsp;Fátima Mitiko Tengan ,&nbsp;Edson Abdala","doi":"10.1016/j.canep.2025.102946","DOIUrl":"10.1016/j.canep.2025.102946","url":null,"abstract":"<div><h3>Background</h3><div>Hepatitis B virus reactivation may occur in cancer patients, leading to liver damage and early discontinuation of treatment. To evaluate vaccine-induced immunity to hepatitis B, this study investigated the prevalence of anti-HBs antibodies from patients with solid tumors or hematological malignancies.</div></div><div><h3>Methods</h3><div>All cancer patients who underwent serological testing for anti-HBs from 2011 to 2023 and had negative anti-HBc results at the Instituto do Cancer do Estado de Sao Paulo, Brazil, were included. The prevalence of vaccine-induced immunity to hepatitis B during those years was assessed by using linear regression. Characteristics associated with presence of anti-HBs and anti-HBs titers (strongly positive: ≥ 100 IU/L; weakly positive: 10–99 IU/L) were evaluated by using multivariable logistic regression.</div></div><div><h3>Results</h3><div>A total of 23,854 patients were evaluated, 17,249 with solid tumors and 5114 with hematological malignancies. The prevalence of vaccine-induced immunity to hepatitis B was 22.1 %, with a significant linear increase over time (p &lt; 0.001). The presence of vaccine-induced immunity to hepatitis B was associated with younger age (OR=7.23, 95 % CI: 6.55–7.98), female sex (OR=1.25, 95 % CI: 1.15–1.36), non-white patients (OR=1.13, 95 % CI: 1.04–1.22), and patients with hematological malignancies (OR=1.16, 95 %CI: 1.07–1.27). Additionally, the variables younger age (OR=1.64, 95 % CI: 1.39–1.94) and female sex (OR=1.39, 95 % CI: 1.20–1.60) were associated with strongly protective anti-HBs titers (≥ 100 IU/L).</div></div><div><h3>Conclusions</h3><div>This finding indicates that approximately one-quarter of a large population with cancer was protected against HBV infection through serological evidence of anti-HBs. Preventive strategies are needed for cancer patients, who may benefit from hepatitis B vaccination.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102946"},"PeriodicalIF":2.3,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145362390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors of Mucoepidermoid Carcinoma within the head and neck: A NCDB analysis","authors":"Sebastian Respicio ,&nbsp;Daniel Ryan ,&nbsp;Christopher Bine ,&nbsp;Stone Zhang ,&nbsp;Peter Silberstein ,&nbsp;Marco DiBlasi","doi":"10.1016/j.canep.2025.102945","DOIUrl":"10.1016/j.canep.2025.102945","url":null,"abstract":"<div><h3>Objectives</h3><div>To characterize the prognostic profile of head and neck Mucoepidermoid Carcinoma (MEC) and correlate findings with survival and surgical likelihood.</div></div><div><h3>Methods</h3><div>This retrospective cohort study queried the National Cancer Database from 2004 to 2021 for all head and neck structures with histologically confirmed MEC. Using SPSS and GraphPad Prism, statistical analyses were conducted via Kaplan Meier Survival with Log-Rank Pairwise Comparisons, Cox Proportional Hazards Regressions, and Binomial and Multinomial Logistic Regressions.</div></div><div><h3>Results</h3><div>A total of 17,713 patients were included. Significant findings include worsened overall survival (OS) and hazard ratios (HR) in relation to male sex, white race, non-Hispanic ethnicity, non-Private Insurances, non-Academic/Research treatment facilities, and not undergoing surgery. MEC in the Gum &amp; Other Mouth and in the Lip had better OS and HR while MEC of the Nose, Nasal Cavity, &amp; Middle Ear, MEC of the Tongue, and MEC of the Pharynx had worsened OS and HR in comparison to Salivary Gland MEC. Gum &amp; Other Mouth MEC patients had significantly increased likelihood for Local Tumor Excision and Partial Organ Removal surgeries. Tongue MEC had significantly increased likelihood for Partial Organ Removal. Nose, Nasal Cavity, &amp; Middle Ear MEC and Pharynx MEC had significantly decreased likelihoods for Local Tumor Excision or Total/Radical Organ Removal Surgeries.</div></div><div><h3>Conclusion</h3><div>By identifying key determinants of survival and surgical likelihood, this work provides valuable clinical insight into patient management and outcomes for a clinically significant malignancy. Additionally, this study comments on the role of accessible surgical care and social determinants of health regarding MEC.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102945"},"PeriodicalIF":2.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional assessment of US cancer diagnoses during the COVID-19 pandemic","authors":"Todd Burus ,&nbsp;Uriel Kim ,&nbsp;Johnie Rose ,&nbsp;Siran M. Koroukian ,&nbsp;Krystle A. Lang Kuhs","doi":"10.1016/j.canep.2025.102944","DOIUrl":"10.1016/j.canep.2025.102944","url":null,"abstract":"<div><h3>Background</h3><div>Disruptions to cancer diagnoses were widely reported in the US during the early COVID-19 pandemic. Whether any cases remained unaccounted-for by the end of the pandemic has not been fully assessed.</div></div><div><h3>Methods</h3><div>We collected data on invasive cancer diagnoses occurring among individuals aged 20–89 years between January 2020 and December 2022 from the Surveillance, Epidemiology, and End Results database. Expected cancer case counts and incidence rates with 95 % credibility intervals (95 %CrIs) were estimated for 2020–2022 from pre-pandemic trends (2005–2019) using Bayesian Age-Period-Cohort models. We compared observed rates with expected rates, and estimated unaccounted-for cases. Additional site-, stage-, and subgroup-specific analyses were performed.</div></div><div><h3>Results</h3><div>Among 2260,704 cancer cases diagnosed in 2020–2022, the observed incidence rate was 595.5 per 100,000 persons (95 %CI, 594.7–596.2), which was 6.7 % lower than the expected rate of 638.1 (95 %CrI, 620.1–656.1) and corresponded to 160,475 fewer-than-expected cases (95 %CrI, 99,777–221,174). Annual observed rates were significantly lower than expected in 2020 (565.8 vs. 630.7), with recovery in 2021 and 2022, though not enough to overcome the existing case deficit. Incidence rates for persons aged ≥ 65 years, nonmetropolitan residents, and non-Hispanic White individuals, as well as site-specific rates for lung and kidney cancers and non-Hodgkin lymphoma, remained below expected levels beyond 2020. Early-stage colorectal cancer diagnoses were 14.2 % lower than expected over the period.</div></div><div><h3>Conclusion</h3><div>While annual cancer incidence rates returned to expected levels by the end of the COVID-19 pandemic, substantial numbers of unaccounted-for cases remained, raising concerns for future increases in cancer morbidity and mortality.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102944"},"PeriodicalIF":2.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intersection of climate change and cancer across global populations: A bibliometric analysis (2000–2024)","authors":"Shibaji Gupta ,&nbsp;Priyadharshini Babu ,&nbsp;Debdutta Haldar ,&nbsp;Subhadip Bag ,&nbsp;Ilham Zaidi ,&nbsp;Sonu Goel","doi":"10.1016/j.canep.2025.102926","DOIUrl":"10.1016/j.canep.2025.102926","url":null,"abstract":"<div><h3>Background</h3><div>The convergence of climate change and cancer is an emerging research area with significant implications for public health. This bibliometric analysis aimed to map the growth, trends, contributors, collaboration networks, and thematic areas related to this field.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed and Scopus databases for peer-reviewed literature published between 2000 and 2024 using predefined keywords. One-hundred and nineteen eligible articles were analyzed for metrics like co-authorship networks and keywords co-occurrence.</div></div><div><h3>Results</h3><div>The volume of research has seen a significant rise since the 2010s. The United States, China, and the United Kingdom were leading contributors, while the Low- and Middle-Income Countries were underrepresented. Dominant research themes included climate change and cancer, pollution and cancer, sun exposure, temperature and skin cancer, and air pollution and climate change. Air pollution and particulate matter were identified as high-density and centrality motor themes.</div></div><div><h3>Conclusion</h3><div>This analysis provides a first-of-its-kind mapping of 2 decades of global research at the intersection of climate change and cancer. Future research should prioritize global South perspectives, context-specific investigations, and longitudinal studies integrating registry data for in-depth studies to elucidate the causal relationships between climate change and cancer types. The oncology community should engage in climate action through mitigation and adaptation strategies.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102926"},"PeriodicalIF":2.3,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignancies of the small intestine: incidence and trends in a nationwide registry","authors":"Pascale J.M. Schafrat ,&nbsp;Felice N. van Erning ,&nbsp;Koos Zwinderman ,&nbsp;Evelien Dekker ,&nbsp;Arantza Farina Sarasqueta ,&nbsp;Judith de Vos-Geelen ,&nbsp;Stefan A.W. Bouwense ,&nbsp;Ruben S.A. Goedegebuure ,&nbsp;Louis Vermeulen ,&nbsp;Ignace H.J.T. de Hingh ,&nbsp;Dirkje W. Sommeijer","doi":"10.1016/j.canep.2025.102943","DOIUrl":"10.1016/j.canep.2025.102943","url":null,"abstract":"<div><h3>Background</h3><div>Malignancies of the small intestine are rare and understudied. Improved knowledge about trends in incidence and distribution of specific subtypes might guide clinicians and researchers to further improve diagnostic and treatment strategies and ultimately improve prognosis.</div></div><div><h3>Methods</h3><div>This nationwide retrospective cohort study from the Netherlands Cancer Registry included all patients diagnosed with a malignancy of the small intestine in the Netherlands between 2000 and 2022. Malignancies were divided into seven subgroups: adenocarcinomas, neuroendocrine neoplasms (NENs), lymphomas, gastrointestinal stromal tumors (GISTs), other sarcomas, metastases, and “other”. Age-standardized incidence rates, overall- and relative survival were reported.</div></div><div><h3>Results</h3><div>A total of 11.194 patients with a malignancy of the small intestine were included. Age-standardized incidence rates (per 100.000 person-years) more than doubled between 2000 and 2020 (1.88–3.94, <em>p &lt; 0.001</em>), with the largest increase in NENs (0.53–1.57, <em>p &lt; 0.001</em>), followed by adenocarcinomas (0.78–1.22, <em>p</em> = 0.004). The most prevalent malignancy in the small intestine shifted from adenocarcinomas to NENs from 2017 onwards. NENs were mostly located in the ileum and adenocarcinomas were most frequently diagnosed in the duodenum. Survival varied significantly between subgroups. Survival of patients with lymphomas and GISTs improved over time, in contrast with patients with adenocarcinomas and NENs.</div></div><div><h3>Conclusion</h3><div>The incidence of malignancies of the small intestine in the Netherlands has more than doubled over the past two decades, mostly due to an increase in NENs and adenocarcinomas. Survival outcomes for these malignancies did not improve, highlighting the urgent need to further study these rare cancer subtypes in the small intestine.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102943"},"PeriodicalIF":2.3,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to handle missing follow-up time: A comparative analysis of contralateral breast cancer incidence","authors":"Sarah R. Haile ,&nbsp;Miriam Wanner ,&nbsp;Dimitri Korol ,&nbsp;Sabine Rohrmann","doi":"10.1016/j.canep.2025.102942","DOIUrl":"10.1016/j.canep.2025.102942","url":null,"abstract":"<div><h3>Background</h3><div>We aimed to compare various common approaches for handling missing vital status or follow-up time. As a case study for application of these methods, we estimated incidence of metachronous contralateral breast cancer (CBC).</div></div><div><h3>Methods</h3><div>For 1980–2016, incidence of metachronous CBC with follow-up through 2024 was estimated using Poisson regression with overdispersion, by age at incidence, year of incidence, histology and follow-up period. Missing follow-up time was ignored in the naive approach, simulated once using the average hazard derived from published Swiss cancer registry data, or multiply imputed using 3 different imputation models.</div></div><div><h3>Results</h3><div>24,612 women aged 20–84 had unilateral breast cancer between 1980 and 2016 in the Swiss cantons of Zurich and Zug. Of those, 5 % (n = 1264) were lost to follow-up. Over 291,463 person-years, 1145 contralateral breast malignancies were diagnosed, corresponding to 393 per 100,000 person-years (95 % CI 353–438). Incidence rates have been decreasing over time to 238 (171−333) for the incidence period 2010–2016. The same overall pattern was observed regardless of how we handled missing follow-up times. However, using a single imputation generally produced lower incidence rates compared to the naive approach, with multiple imputation giving higher estimates. The most complex multiple imputation model gave incidence estimates that were very similar to those from the naive approach.</div></div><div><h3>Conclusion</h3><div>Different methods to handle missing follow-up times yielded similar results: that CBC incidence has declined in recent decades. Multiple imputation is likely an appropriate method to handle missing follow-up data, enabling researchers to include all eligible individuals in the analysis.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102942"},"PeriodicalIF":2.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging data gaps: Methodological advances in extracting and analyzing genetic information from unstructured clinical records in hereditary cancer","authors":"Danny Styvens Cardona ,&nbsp;Juan Pablo Valencia-Arango ,&nbsp;Juan Pablo Gallo ,&nbsp;Catalina Andrea Bustamante ,&nbsp;Richard Orlando Salazar ,&nbsp;Carlos Andrés Carmona ,&nbsp;Melisa Naranjo Vanegas ,&nbsp;Carolina Jaramillo Jaramillo ,&nbsp;Juliana Espinosa Moncada ,&nbsp;Harvy Mauricio Velasco ,&nbsp;Natalia Gallego Lopera","doi":"10.1016/j.canep.2025.102940","DOIUrl":"10.1016/j.canep.2025.102940","url":null,"abstract":"<div><h3>Introduction</h3><div>The global impact of cancer, driven by both acquired and hereditary mutations, underscores the necessity for extensive research efforts. Despite the increasing volume of genetic data, significant gaps remain in data science research, particularly in Latinos and admixed populations. This study utilizes advanced data science techniques to integrate genetic and clinical data, aiming to improve the understanding of hereditary cancer in Colombia and demonstrating the transformative potential of data-driven approaches in cancer research.</div></div><div><h3>Methods</h3><div>This observational study analyzed healthcare databases from four regions and 11 cities in Colombia. Genetic data were extracted from PDF reports within SURA Colombia's Electronic Health Records (a Latin American health insurance provider) for individuals referred for hereditary cancer testing between October 2019 and November 2021. Variants in 30 genes, aligned with NCCN guidelines, were examined using Next-Generation Sequencing (NGS). Data extraction was automated using Python and R, followed by integration and analysis of genetic, clinical, and sociodemographic data using advanced data science tools hosted on Azure infrastructure. These tools enabled predictive modeling and cross-referencing to explore correlations between genetic variants and clinical outcomes.</div></div><div><h3>Results</h3><div>The study included 1377 patients, with a predominance of women (92.81 %) and 63 % from the northwestern region of Colombia. The largest age group (40.37 %) was between 31 and 44 years, and 95.35 % had a personal cancer history, primarily breast cancer (75.86 %). Hereditary cancer testing revealed 145 positive results and 587 uncertain outcomes. Data science-driven analysis identified higher positivity rates in patients aged 31–44 and over 50, particularly in the northeast and central regions. Among positive results, 42.6 % included variants of uncertain significance, with 95.9 % of these patients having a personal cancer history.</div></div><div><h3>Conclusion</h3><div>This study highlights the significant role of data science in analyzing hereditary cancer data. Advanced computational techniques can aid in genetic variant reclassification, uncover patterns in underrepresented populations, and inform personalized interventions for hereditary cancer management in Latin America.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102940"},"PeriodicalIF":2.3,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational heat exposure and stomach cancer risk in a pooled analysis of two Spanish case-control studies in the stomach cancer pooling project – StoP consortium","authors":"Alice Hinchliffe ,&nbsp;Miquel Vallbona-Vistós ,&nbsp;Juan Alguacil ,&nbsp;Manolis Kogevinas ,&nbsp;Sanni Uuksulainen ,&nbsp;Nuria Aragonés ,&nbsp;Adonina Tardón ,&nbsp;Jesus Vioque ,&nbsp;Mary H. Ward ,&nbsp;Charles S. Rabkin ,&nbsp;M. Constanza Camargo ,&nbsp;Claudio Pelucchi ,&nbsp;Carlo La Vecchia ,&nbsp;Paolo Boffetta ,&nbsp;Michelle C. Turner","doi":"10.1016/j.canep.2025.102938","DOIUrl":"10.1016/j.canep.2025.102938","url":null,"abstract":"<div><h3>Background</h3><div>Occupational heat stress occurs frequently and is increasing with climate change. Studies of occupational heat exposure and stomach cancer risk are limited. We used data from the international Stomach cancer Pooling (StoP) Project to investigate the relationship between occupational heat exposure and stomach cancer risk in a pooled analysis of two Spanish case-control studies, including 566 stomach cancer cases and 2984 controls.</div></div><div><h3>Methods</h3><div>The Spanish job-exposure matrix, MatEmEsp, was used to assign heat exposure estimates to participant occupations. We evaluated three exposure indices: ever vs. never exposed, cumulative exposure and duration (years). We calculated odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) using unconditional logistic regression models including terms for potential confounders.</div></div><div><h3>Results</h3><div>Overall, 60.6 % of cases and 42.7 % of controls were ever occupationally exposed to heat. Occupational heat exposure was associated with a moderately elevated risk of stomach cancer (OR 1.31; 95 % CI 1.05, 1.63) when comparing ever vs. never exposed individuals in both studies combined. Elevated ORs were also observed across categories of cumulative exposure and duration (p-trend = 0.01 and 0.03, respectively). Findings were robust to additional covariate adjustment and in analysis of never smokers. There was no clear evidence for interaction according to exposure status to other suspected occupational stomach carcinogens.</div></div><div><h3>Conclusion</h3><div>Findings from this study provide some evidence for a positive association between occupational heat exposure and stomach cancer risk. Further research is needed to advance occupational heat assessment tools for epidemiological research as well as studies in more geographically diverse populations.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102938"},"PeriodicalIF":2.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium intake and gastric cancer risk: A systematic review and dose–response meta-analysis of observational studies","authors":"Alex Richard Costa Silva ,&nbsp;Marcela de Araújo Fagundes ,&nbsp;Valdete Regina Guandalini ,&nbsp;Maria Paula Curado","doi":"10.1016/j.canep.2025.102939","DOIUrl":"10.1016/j.canep.2025.102939","url":null,"abstract":"<div><div>Calcium has been proposed as a protective factor against certain types of cancer, but findings related to gastric cancer (GC) are inconsistent. This meta-analysis aimed to assess the association between calcium intake and the risk of GC. A comprehensive search was conducted in PubMed, Scopus, EMBASE, LILACS, and Web of Science for cohort and case-control studies published up to August 19, 2024. The quality of the studies was assessed using the Newcastle–Ottawa Scale. Publication bias was tested using Egger’s and Begg’s tests. Relative risks (RRs) and 95 % confidence intervals (CIs) were pooled through a random-effects model. Given the substantial heterogeneity and potential variation in intake levels across populations, a dose-response analysis was conducted to explore potential trends across the full range of calcium consumption. Thirteen studies involving 1,610,992 participants met the inclusion criteria. A non-significant inverse association was observed between total calcium intake and GC risk when comparing the highest vs lowest intake categories (RR: 0.85; 95 % CI: 0.70–1.05). While this categorical comparison was not statistically significant, the dose-response analysis revealed a significant linear protective effect, with a 10 % reduction in risk per 300 mg/day increase in dietary calcium intake (RR: 0.90; 95 % CI: 0.82–0.99). To account for potential variations across intake levels, a non-linear model was also applied, indicating a clearer risk reduction above 400 mg/day (p for non-linearity &lt; 0.001). Overall, this dose-response meta-analysis suggests that higher dietary calcium intake may have a protective effect against GC, reinforcing the importance of considering calcium in dietary strategies for GC prevention, although more studies are needed to confirm these findings.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102939"},"PeriodicalIF":2.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}