The application of organic solid–liquid phase change materials (PCMs) is limited for the leakage problem after phase change and high rigidity. In this work, a novel flexible solid–solid PCM (DXPCM) was synthesized using a block copolymerization process with polyethylene glycol (PEG) as the energy storage segment. The phase transition temperature (from 36.2 to 49.4 °C) and enthalpy (from 83.27 to 123.35 J/g) of DXPCM could be changed through adjusting the molecular weight of PEG. The introduction of hard chain segments endowed DXPCM with excellent flexibility, foldability, and mechanical properties at room temperature. The large number of internal hydrogen bonds and π–π stacking provided DXPCM with interesting thermally induced switchable adhesion and recyclability. The storage and release of elastic potential energy ensured that DXPCM could recover its original shape after being deformed by external forces. It is worth mentioning that DXPCM exhibits excellent infrared stealth capability as it can absorb and release latent heat for a long period of time. In conclusion, this work developed a novel solid–solid phase change film with high mechanical strength, thermally induced switchable adhesion, and shape recovery capability, which has great potential for application in infrared stealth.
{"title":"Multifunctional Phase Change Films with High Mechanical Strength, Thermally Induced Switchable Adhesion, and Shape Recoverability for Infrared Stealth","authors":"Guangyu Zhu, Wenjing Chen, Xiaowu Hu, Wenxing Luo, Yan Ma, Jue Wang, Sifan Tan, Yifan Huang, Jinghui Fan, Xiongxin Jiang, Qinglin Li","doi":"10.1021/acsami.4c18276","DOIUrl":"https://doi.org/10.1021/acsami.4c18276","url":null,"abstract":"The application of organic solid–liquid phase change materials (PCMs) is limited for the leakage problem after phase change and high rigidity. In this work, a novel flexible solid–solid PCM (DXPCM) was synthesized using a block copolymerization process with polyethylene glycol (PEG) as the energy storage segment. The phase transition temperature (from 36.2 to 49.4 °C) and enthalpy (from 83.27 to 123.35 J/g) of DXPCM could be changed through adjusting the molecular weight of PEG. The introduction of hard chain segments endowed DXPCM with excellent flexibility, foldability, and mechanical properties at room temperature. The large number of internal hydrogen bonds and π–π stacking provided DXPCM with interesting thermally induced switchable adhesion and recyclability. The storage and release of elastic potential energy ensured that DXPCM could recover its original shape after being deformed by external forces. It is worth mentioning that DXPCM exhibits excellent infrared stealth capability as it can absorb and release latent heat for a long period of time. In conclusion, this work developed a novel solid–solid phase change film with high mechanical strength, thermally induced switchable adhesion, and shape recovery capability, which has great potential for application in infrared stealth.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"50 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fast-response photodetectors have attracted considerable attention in the application of high-speed communication, real-time monitoring, and optical imaging systems. However, most reported photodetectors suffer from limitations of the inherent properties of materials, low carrier transport efficiency, and unmatched interfaces, which lead to a low response speed. Here, we report a WS2/graphene/MoS2 vertical van der Waals heterojunction fabricated by mechanical exfoliation and dry transfer methods for fast response. To improve the response speed of the previously reported WS2/MoS2 heterojunction with excellent photoelectric performances, the embedded graphene is employed to optimize the interface defects and improve the carrier transport efficiency due to its high mobility and smooth and flat surface. Under the illuminations of a 405 nm laser and a bias voltage of 0.5 V, our device can realize rise and fall times of 44 and 52 μs, respectively. For a bias voltage of 2.5 V, moreover, the device can also show outstanding performances including a high responsivity of 220 A/W, a considerable detectivity of 1.2 × 1013 Jones, a large external quantum efficiency of 6.7 × 104 %, and a low dark current of 1.05 × 10–13 A. Additionally, the device enables high-speed transmission with a low bit error rate in a closed-loop optical communication system. Therefore, the proposed scheme can provide an idea for the design of photodetectors with fast response and high performance.
{"title":"WS2/Graphene/MoS2 Sandwich van der Waals Heterojunction for Fast-Response Photodetectors","authors":"Yongzhi Zhang, Xunjun He","doi":"10.1021/acsami.4c13818","DOIUrl":"https://doi.org/10.1021/acsami.4c13818","url":null,"abstract":"Fast-response photodetectors have attracted considerable attention in the application of high-speed communication, real-time monitoring, and optical imaging systems. However, most reported photodetectors suffer from limitations of the inherent properties of materials, low carrier transport efficiency, and unmatched interfaces, which lead to a low response speed. Here, we report a WS<sub>2</sub>/graphene/MoS<sub>2</sub> vertical van der Waals heterojunction fabricated by mechanical exfoliation and dry transfer methods for fast response. To improve the response speed of the previously reported WS<sub>2</sub>/MoS<sub>2</sub> heterojunction with excellent photoelectric performances, the embedded graphene is employed to optimize the interface defects and improve the carrier transport efficiency due to its high mobility and smooth and flat surface. Under the illuminations of a 405 nm laser and a bias voltage of 0.5 V, our device can realize rise and fall times of 44 and 52 μs, respectively. For a bias voltage of 2.5 V, moreover, the device can also show outstanding performances including a high responsivity of 220 A/W, a considerable detectivity of 1.2 × 10<sup>13</sup> Jones, a large external quantum efficiency of 6.7 × 10<sup>4</sup> %, and a low dark current of 1.05 × 10<sup>–13</sup> A. Additionally, the device enables high-speed transmission with a low bit error rate in a closed-loop optical communication system. Therefore, the proposed scheme can provide an idea for the design of photodetectors with fast response and high performance.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"13 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Extracellular vesicles (EVs) present a promising modality for numerous biological and medical applications, including therapeutics. Developing facile methods to engineer EVs is essential to meeting the rapidly expanding demand for various functionalized EVs in these applications. Herein, we developed a technology that integrates enzymatic glycoengineering and microfluidics for effective EV functionalization. This method builds on a 3D nanostructured microfluidic device to streamline a multiple-step EV engineering process, which involves a step of enzymatic reaction to install azido-sialic acid residues to glycans on EVs using a sialyltransferase and an azide-tagged sialyl donor followed by the attachment of various functionalities, such as biotin and fluorescent labels, to the resulting azido-glycans on EVs through a biocompatible click reaction. Compared to traditional EV engineering methods, we show that our technology improves the efficiency of EV glycoengineering while simplifying and expediting the workflow. Furthermore, we demonstrated the applicability of this technology to EVs derived from the cell lines of different cancer types, including A549, PC3, and COLO-1 cells. Overall, this EV engineering technology could provide a potentially useful tool for broad applications.
{"title":"Efficient Enzymatic Glycan Engineering of Extracellular Vesicles Using Nanomaterial-Interfaced Microfluidics","authors":"Xin Zhou, Mohit Jaiswal, Jingzhu Shi, Jiatong Guo, Sayan Kundu, Zhongwu Guo, Yong Zeng","doi":"10.1021/acsami.4c20294","DOIUrl":"https://doi.org/10.1021/acsami.4c20294","url":null,"abstract":"Extracellular vesicles (EVs) present a promising modality for numerous biological and medical applications, including therapeutics. Developing facile methods to engineer EVs is essential to meeting the rapidly expanding demand for various functionalized EVs in these applications. Herein, we developed a technology that integrates enzymatic glycoengineering and microfluidics for effective EV functionalization. This method builds on a 3D nanostructured microfluidic device to streamline a multiple-step EV engineering process, which involves a step of enzymatic reaction to install azido-sialic acid residues to glycans on EVs using a sialyltransferase and an azide-tagged sialyl donor followed by the attachment of various functionalities, such as biotin and fluorescent labels, to the resulting azido-glycans on EVs through a biocompatible click reaction. Compared to traditional EV engineering methods, we show that our technology improves the efficiency of EV glycoengineering while simplifying and expediting the workflow. Furthermore, we demonstrated the applicability of this technology to EVs derived from the cell lines of different cancer types, including A549, PC3, and COLO-1 cells. Overall, this EV engineering technology could provide a potentially useful tool for broad applications.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"23 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shao-Hsiang Joe Hung, Meng-Chen Chiang, Jessica D. Schiffman
Polymeric membranes fabricated via the nonsolvent-induced phase separation process rely heavily on toxic aprotic organic solvents, like N-methyl-pyrrolidine (NMP) and dimethylformamide. We suggest that the “saloplastic” nature of polyelectrolyte complexes (PECs) makes them an excellent candidate for fabricating next-generation water purification membranes that use a more sustainable aqueous phase separation process. In this study, we investigate how the properties of PECs and their interactions with salt can form pore-containing membranes from the strong polyelectrolytes poly(sodium 4-styrenesulfonate) (PSS) and poly(diallyldimethylammonium chloride) (PDADMAC) in the presence of potassium bromide (KBr). How the single-phase polymer-rich (coacervate) dope solution and coagulation bath impacted the formation, morphology, and pure water permeance (PWP) of the membranes was systematically evaluated by using scanning electron microscopy and dead-end filtration tests. The impact of a salt annealing post-treatment process was also tested; these treated PEC membranes exhibited a PWP of 6.2 L m–2 h–1 bar–1 and a dye removal of 91.7% and 80.5% for methyl orange and methylene blue, respectively, which are on par with commercial poly(ether sulfone) nanofiltration membranes. For the first time, we have demonstrated the ability of the PEC membranes to repel Escherichia coli bacteria under static conditions. Our fundamental study of polyelectrolyte membrane pore-forming mechanisms and separation performance could help drive the future development of sustainable materials for membrane-based separations.
{"title":"Optimization of Polyelectrolyte Coacervate Membranes via Aqueous Phase Separation","authors":"Shao-Hsiang Joe Hung, Meng-Chen Chiang, Jessica D. Schiffman","doi":"10.1021/acsami.4c18989","DOIUrl":"https://doi.org/10.1021/acsami.4c18989","url":null,"abstract":"Polymeric membranes fabricated via the nonsolvent-induced phase separation process rely heavily on toxic aprotic organic solvents, like <i>N</i>-methyl-pyrrolidine (NMP) and dimethylformamide. We suggest that the “saloplastic” nature of polyelectrolyte complexes (PECs) makes them an excellent candidate for fabricating next-generation water purification membranes that use a more sustainable aqueous phase separation process. In this study, we investigate how the properties of PECs and their interactions with salt can form pore-containing membranes from the strong polyelectrolytes poly(sodium 4-styrenesulfonate) (PSS) and poly(diallyldimethylammonium chloride) (PDADMAC) in the presence of potassium bromide (KBr). How the single-phase polymer-rich (coacervate) dope solution and coagulation bath impacted the formation, morphology, and pure water permeance (PWP) of the membranes was systematically evaluated by using scanning electron microscopy and dead-end filtration tests. The impact of a salt annealing post-treatment process was also tested; these treated PEC membranes exhibited a PWP of 6.2 L m<sup>–2</sup> h<sup>–1</sup> bar<sup>–1</sup> and a dye removal of 91.7% and 80.5% for methyl orange and methylene blue, respectively, which are on par with commercial poly(ether sulfone) nanofiltration membranes. For the first time, we have demonstrated the ability of the PEC membranes to repel <i>Escherichia coli</i> bacteria under static conditions. Our fundamental study of polyelectrolyte membrane pore-forming mechanisms and separation performance could help drive the future development of sustainable materials for membrane-based separations.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"271 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Two dimensional covalent organic framework (2D COF) films based on triphenylamine are considered to be promising electrochromic and energy-storage materials owing to their interlayer π–π electron delocalization, one-dimensional (1D) nanopores, and stable chemical structures. Triphenylamine-based 2D COF electrochromic films, nevertheless, rarely exhibit transparency and high optical contrast, which severely limited the scope of their application. In this work, two directly grown triphenylamine-based polyimide 2D COF films, TAPA-PMDA and TAPA-NTCDA PI COF, were prepared through solvothermal technology. Their morphologies were assembled into hierarchical nanoporous structures in the form of strips and gravel-like nanograins, respectively. Both the TAPA-PMDA and TAPA-NTCDA PI COF films exhibited a transparent bleached state and high optical contrast. Their optical contrasts were 77.6% at 752 nm and 60.4% at 708 nm, respectively. Interestingly, the TAPA-NTCDA PI COF film could exhibit multicolors (transparent, red-gray, and blue-gray) through regulating the contributions of the electron transition from HOMO to SOMO and HOMO-1 to SOMO of TPA+•. In addition, the TAPA-PMDA and TAPA-NTCDA PI COF films also displayed fast switching and colored/bleached times of 7.3/2.7 and 5.3/8.1 s, respectively. Remarkably, the TAPA-PMDA PI COF film also demonstrated large specific capacitance and excellent charge–discharge rate capabilities. The directly grown polyimide 2D COF films are enormously promising for high-performance electrochromic and energy-storage materials.
基于三苯胺的二维共价有机框架（2D COF）薄膜具有层间π-π电子脱ocal、一维（1D）纳米孔和稳定的化学结构，因此被认为是一种很有前途的电致变色和储能材料。然而，基于三苯胺的二维 COF 电致变色薄膜很少表现出透明度和高光学对比度，这严重限制了其应用范围。本研究通过溶热技术制备了两种直接生长的三苯胺基聚酰亚胺二维 COF 薄膜，即 TAPA-PMDA 和 TAPA-NTCDA PI COF。它们的形态分别以条状和砾石状纳米颗粒的形式组装成分层纳米多孔结构。TAPA-PMDA 和 TAPA-NTCDA PI COF 薄膜均呈现出透明漂白状态和高光学对比度。它们在 752 纳米波长和 708 纳米波长下的光学对比度分别为 77.6% 和 60.4%。有趣的是，通过调节 TPA+- 的 HOMO 到 SOMO 和 HOMO-1 到 SOMO 的电子转变贡献率，TAPA-NTCDA PI COF 薄膜可以呈现出多种颜色（透明、红灰色和蓝灰色）。此外，TAPA-PMDA 和 TAPA-NTCDA PI COF 薄膜还显示出快速切换，着色/漂白时间分别为 7.3/2.7 秒和 5.3/8.1 秒。值得注意的是，TAPA-PMDA PI COF 薄膜还表现出较大的比电容和出色的充放电速率能力。直接生长的聚酰亚胺二维 COF 薄膜在高性能电致变色和储能材料方面具有巨大的应用前景。
{"title":"Directly Grown Polyimide Covalent Organic Framework Films with High Electrochromic and Energy-Storage Performance","authors":"Haolin Xie, Qingqing Qiu, Huan Li, Ping Liu, Putrakumar Balla, Xiaopeng Qi, Tongxiang Liang, Jinming Zeng","doi":"10.1021/acsami.4c16702","DOIUrl":"https://doi.org/10.1021/acsami.4c16702","url":null,"abstract":"Two dimensional covalent organic framework (2D COF) films based on triphenylamine are considered to be promising electrochromic and energy-storage materials owing to their interlayer π–π electron delocalization, one-dimensional (1D) nanopores, and stable chemical structures. Triphenylamine-based 2D COF electrochromic films, nevertheless, rarely exhibit transparency and high optical contrast, which severely limited the scope of their application. In this work, two directly grown triphenylamine-based polyimide 2D COF films, TAPA-PMDA and TAPA-NTCDA PI COF, were prepared through solvothermal technology. Their morphologies were assembled into hierarchical nanoporous structures in the form of strips and gravel-like nanograins, respectively. Both the TAPA-PMDA and TAPA-NTCDA PI COF films exhibited a transparent bleached state and high optical contrast. Their optical contrasts were 77.6% at 752 nm and 60.4% at 708 nm, respectively. Interestingly, the TAPA-NTCDA PI COF film could exhibit multicolors (transparent, red-gray, and blue-gray) through regulating the contributions of the electron transition from HOMO to SOMO and HOMO-1 to SOMO of TPA<sup>+•</sup>. In addition, the TAPA-PMDA and TAPA-NTCDA PI COF films also displayed fast switching and colored/bleached times of 7.3/2.7 and 5.3/8.1 s, respectively. Remarkably, the TAPA-PMDA PI COF film also demonstrated large specific capacitance and excellent charge–discharge rate capabilities. The directly grown polyimide 2D COF films are enormously promising for high-performance electrochromic and energy-storage materials.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"19 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In organic field-effect transistors (OFETs), the high carrier mobility of conjugated polymers (CPs) is significantly influenced by the maintenance of excellent coplanarity and aggregation, especially at the interface between the organic semiconductor and dielectric layer. Unfortunately, CPs typically exhibit poor coplanarity due to the single bond rotations between donor and acceptor units. Furthermore, there is relatively little research on the coplanarity of CPs at the interface. Herein, we propose a strategy of introducing noncovalent interactions to enhance the coplanarity of the backbone and promote the aggregation of the polymer at the interface, which should lead to significant enhancements in carrier mobility. The idea is proved by incorporating different volume fractions of oleic acid (OA) into poly(indacenodithiophene-co-benzothiadiazole) (IDTBT). OA can form hydrogen bonds, which has been verified by Fourier transform infrared spectroscopy (FT-IR). OA promotes the migration of IDTBT toward the interface, thereby enhancing aggregation, as verified by film-depth-dependent light absorption spectroscopy (FLAS) and contact angle (CA) experiments. The results from film-depth-dependent Raman spectroscopy (FRS), two-dimensional grazing incidence wide-angle X-ray scattering (2D GIWAXS), atomic force microscopy (AFM), and density functional theory (DFT) calculations suggest that films treated with OA exhibit enhanced backbone coplanarity and aggregation at the interface, resulting in an increase in carrier mobility to 4.24 ± 0.11 cm2 V–1 s–1 with the addition of OA.
{"title":"Introducing Noncovalent Interactions in Conjugated Polymers to Enhance Backbone Coplanarity and Aggregation at the Interface to Improve Carrier Mobility","authors":"Yiting Liu, Rui Chen, Junhang Li, Xinyu Liu, Hongxiang Li, Yanchun Han","doi":"10.1021/acsami.4c16351","DOIUrl":"https://doi.org/10.1021/acsami.4c16351","url":null,"abstract":"In organic field-effect transistors (OFETs), the high carrier mobility of conjugated polymers (CPs) is significantly influenced by the maintenance of excellent coplanarity and aggregation, especially at the interface between the organic semiconductor and dielectric layer. Unfortunately, CPs typically exhibit poor coplanarity due to the single bond rotations between donor and acceptor units. Furthermore, there is relatively little research on the coplanarity of CPs at the interface. Herein, we propose a strategy of introducing noncovalent interactions to enhance the coplanarity of the backbone and promote the aggregation of the polymer at the interface, which should lead to significant enhancements in carrier mobility. The idea is proved by incorporating different volume fractions of oleic acid (OA) into poly(indacenodithiophene-<i>co</i>-benzothiadiazole) (IDTBT). OA can form hydrogen bonds, which has been verified by Fourier transform infrared spectroscopy (FT-IR). OA promotes the migration of IDTBT toward the interface, thereby enhancing aggregation, as verified by film-depth-dependent light absorption spectroscopy (FLAS) and contact angle (CA) experiments. The results from film-depth-dependent Raman spectroscopy (FRS), two-dimensional grazing incidence wide-angle X-ray scattering (2D GIWAXS), atomic force microscopy (AFM), and density functional theory (DFT) calculations suggest that films treated with OA exhibit enhanced backbone coplanarity and aggregation at the interface, resulting in an increase in carrier mobility to 4.24 ± 0.11 cm<sup>2</sup> V<sup>–1</sup> s<sup>–1</sup> with the addition of OA.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"110 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dezun Ma, Yajuan Su, Navatha Shree Sharma, Grant Hatcher, Gitali Ganguli-Indra, Arup K. Indra, Adrian F. Gombart, Jingwei Xie
Human cathelicidin LL-37 offers significant benefits to the immune system and in treating various diseases, but its therapeutic potential is hindered by low activity and instability in physiological environments. Here, we introduce a strategy to boost LL-37 levels in exosomes derived from THP-1 monocytes by incubating cells with electrospun nanofibers containing immunomodulators (e.g., 1α, 25-dihydroxyvitamin D3 and VID400). Notably, the incubation with immunomodulator-loaded nanofibers not only increased LL-37 content in exosomes but also significantly enhanced the production of engineered exosomes. Moreover, these engineered exosomes demonstrated multiple biological activities, including promoting skin cell proliferation and migration, enhancing endothelial cell tube formation, and exhibiting antibacterial properties. Collectively, this study presents an approach to increasing both the yield of engineered exosomes and their LL-37 content, potentially offering a promising therapeutic option for wound healing, tissue regeneration, and infectious disease treatment.
{"title":"Prolonged Immunomodulator Delivery Boosts Monocyte Exosome Secretion and Elevates Cathelicidin/LL-37 Content","authors":"Dezun Ma, Yajuan Su, Navatha Shree Sharma, Grant Hatcher, Gitali Ganguli-Indra, Arup K. Indra, Adrian F. Gombart, Jingwei Xie","doi":"10.1021/acsami.4c20695","DOIUrl":"https://doi.org/10.1021/acsami.4c20695","url":null,"abstract":"Human cathelicidin LL-37 offers significant benefits to the immune system and in treating various diseases, but its therapeutic potential is hindered by low activity and instability in physiological environments. Here, we introduce a strategy to boost LL-37 levels in exosomes derived from THP-1 monocytes by incubating cells with electrospun nanofibers containing immunomodulators (e.g., 1α, 25-dihydroxyvitamin D<sub>3</sub> and VID400). Notably, the incubation with immunomodulator-loaded nanofibers not only increased LL-37 content in exosomes but also significantly enhanced the production of engineered exosomes. Moreover, these engineered exosomes demonstrated multiple biological activities, including promoting skin cell proliferation and migration, enhancing endothelial cell tube formation, and exhibiting antibacterial properties. Collectively, this study presents an approach to increasing both the yield of engineered exosomes and their LL-37 content, potentially offering a promising therapeutic option for wound healing, tissue regeneration, and infectious disease treatment.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"72 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ZnO nanoparticles with high safety and stability are often used as active ingredients in sunscreens to protect the skin from ultraviolet rays. However, ZnO nanoparticles are easy to agglomerate, which will significantly affect the ultraviolet absorption and bacteriostatic properties, and the reactive oxygen species induced by the photocatalytic activity may result in irreversible secondary damage to the skin. Herein, the ZnO nanoparticles are dispersed uniformly on the surface of latex particles, and these composite particles are used as shell materials to construct self-assembled colloidosomes by high-gravity technology, which can improve the application properties with synergistic enrichment of the hollow structure. The ultraviolet resistance of colloidosomes is significantly higher than that of the pure ZnO nanoparticles. The higher the loading capacity, the more obvious the inhibition effect of colloidosomes on the growth of Gram bacteria. Furthermore, the antioxidant anthocyanin is in situ encapsulated in colloidosomes, and at a concentration of 2 g/L, the high free radical scavenging rate of 78% can be achieved. The construction of multifunctional colloidosomes provides a route for sunscreen and cosmetics applications.
{"title":"Multifunctional ZnO-Loaded Colloidosomes with Multiple Synergies as a UV Filter","authors":"Jia Jia, Rong-Kun Liu, Qian Sun, Jie-Xin Wang","doi":"10.1021/acsami.4c18007","DOIUrl":"https://doi.org/10.1021/acsami.4c18007","url":null,"abstract":"ZnO nanoparticles with high safety and stability are often used as active ingredients in sunscreens to protect the skin from ultraviolet rays. However, ZnO nanoparticles are easy to agglomerate, which will significantly affect the ultraviolet absorption and bacteriostatic properties, and the reactive oxygen species induced by the photocatalytic activity may result in irreversible secondary damage to the skin. Herein, the ZnO nanoparticles are dispersed uniformly on the surface of latex particles, and these composite particles are used as shell materials to construct self-assembled colloidosomes by high-gravity technology, which can improve the application properties with synergistic enrichment of the hollow structure. The ultraviolet resistance of colloidosomes is significantly higher than that of the pure ZnO nanoparticles. The higher the loading capacity, the more obvious the inhibition effect of colloidosomes on the growth of <i>Gram</i> bacteria. Furthermore, the antioxidant anthocyanin is in situ encapsulated in colloidosomes, and at a concentration of 2 g/L, the high free radical scavenging rate of 78% can be achieved. The construction of multifunctional colloidosomes provides a route for sunscreen and cosmetics applications.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"80 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huiran Yang, Chenhao Lu, Wangdi Zhang, Xupeng Li, Mengting Qi, Dongdong Han, Pu Wang, Yiqing Xie, Lu Li, Feng Zhao
Janus transition metal disulfide (TMD) monolayers have two distinct carbon surfaces that break the inherent ground external mirror symmetry. When compared to traditional TMD materials, Janus TMDs not only inherit the advantages of traditional TMDs but also have new characteristics that are different from those of traditional TMDs. This paper describes the development of a stable passive Q-switched ytterbium-doped fiber laser (YDFL) with operating wavelengths of 1032.9 and 1030.6 nm using two saturated absorbing materials: tantalum sulfide (TaSSe) and tantalum disulfide (TaS2). Our experimental results show that TaSSe, as a saturable absorber (SA), can generate a higher single-pulse energy and withstand higher pump power, and the single maximum pulse energy can reach 108.81 nJ. In the TaS2-SA Q-switched YDFL, increasing pump power from 180 to 330 mW results in a minimum pulse width of 3.18 μs. The maximum pulse energy is 50.68 nJ. This study showed that Janus TMD TaSSe has superior optical properties compared to traditional TMD TaS2, indicating that it has great potential for use in fiber laser development.
{"title":"Application and Output Performance Comparison of Janus and Traditional Transition Metal Chalcogenides in Ytterbium-Doped Fiber Lasers","authors":"Huiran Yang, Chenhao Lu, Wangdi Zhang, Xupeng Li, Mengting Qi, Dongdong Han, Pu Wang, Yiqing Xie, Lu Li, Feng Zhao","doi":"10.1021/acsami.4c13636","DOIUrl":"https://doi.org/10.1021/acsami.4c13636","url":null,"abstract":"Janus transition metal disulfide (TMD) monolayers have two distinct carbon surfaces that break the inherent ground external mirror symmetry. When compared to traditional TMD materials, Janus TMDs not only inherit the advantages of traditional TMDs but also have new characteristics that are different from those of traditional TMDs. This paper describes the development of a stable passive Q-switched ytterbium-doped fiber laser (YDFL) with operating wavelengths of 1032.9 and 1030.6 nm using two saturated absorbing materials: tantalum sulfide (TaSSe) and tantalum disulfide (TaS<sub>2</sub>). Our experimental results show that TaSSe, as a saturable absorber (SA), can generate a higher single-pulse energy and withstand higher pump power, and the single maximum pulse energy can reach 108.81 nJ. In the TaS<sub>2</sub>-SA Q-switched YDFL, increasing pump power from 180 to 330 mW results in a minimum pulse width of 3.18 μs. The maximum pulse energy is 50.68 nJ. This study showed that Janus TMD TaSSe has superior optical properties compared to traditional TMD TaS<sub>2</sub>, indicating that it has great potential for use in fiber laser development.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"97 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medium-wide-bandgap (MWBG) organic photovoltaic (OPV) cells have emerged as a promising category with distinctive application possibilities, especially in environments characterized by specific light conditions, such as indoor spaces. However, there are few high-efficiency MWBG acceptors, and most of them are constructed through high-cost fused central units, which limits the industrialization of MWBG OPV cells. Here, two completely nonfused MWBG acceptors, TBT-38 and TBT-43 with different alkoxy substituent positions on the thiophene rings, are synthesized. Due to the simple synthetic route and high yield, TBT-38 achieves the lowest material-only cost among high-efficiency MWBG acceptors. When blended with high-performance donor PBQx-TF, the TBT-43-based OPV cell exhibits a power conversion efficiency (PCE) of only 8.33%. In contrast, primarily due to higher exciton dissociation efficiency, charge transport capability, and favorable morphology, the TBT-38-based OPV cell delivers a PCE of 13.5% under one sun illumination, which is one of the highest results for completely nonfused OPV cells with absorption onset below 800 nm. Besides, the PBQx-TF:TBT-38-based OPV cell exhibits a PCE of 24.1% under indoor lighting. Our work presents a practical strategy for designing cost-efficient MWBG acceptors.
{"title":"Design and Synthesis of Completely Nonfused Medium-Wide-Bandgap Acceptors for Efficient Organic Photovoltaic Cells","authors":"Shuohan Cheng, Ni Yang, Yong Cui, Wenxuan Wang, Yang Xiao, Jiangbo Dai, Junzhen Ren, Yafei Wang, Jianqiu Wang, Zhihao Chen, Yue Yu, Jianhui Hou","doi":"10.1021/acsami.4c17283","DOIUrl":"https://doi.org/10.1021/acsami.4c17283","url":null,"abstract":"Medium-wide-bandgap (MWBG) organic photovoltaic (OPV) cells have emerged as a promising category with distinctive application possibilities, especially in environments characterized by specific light conditions, such as indoor spaces. However, there are few high-efficiency MWBG acceptors, and most of them are constructed through high-cost fused central units, which limits the industrialization of MWBG OPV cells. Here, two completely nonfused MWBG acceptors, TBT-38 and TBT-43 with different alkoxy substituent positions on the thiophene rings, are synthesized. Due to the simple synthetic route and high yield, TBT-38 achieves the lowest material-only cost among high-efficiency MWBG acceptors. When blended with high-performance donor PBQx-TF, the TBT-43-based OPV cell exhibits a power conversion efficiency (PCE) of only 8.33%. In contrast, primarily due to higher exciton dissociation efficiency, charge transport capability, and favorable morphology, the TBT-38-based OPV cell delivers a PCE of 13.5% under one sun illumination, which is one of the highest results for completely nonfused OPV cells with absorption onset below 800 nm. Besides, the PBQx-TF:TBT-38-based OPV cell exhibits a PCE of 24.1% under indoor lighting. Our work presents a practical strategy for designing cost-efficient MWBG acceptors.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"20 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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