ACS Applied Materials & Interfaces最新文献

英文中文

Snapping Endows Magnetoelectric Metamaterials with Passive Power-up Conversion

IF 9.5 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces

Pub Date : 2025-02-03 DOI: 10.1021/acsami.4c15670

Kai Tan, Rong Jia, Qian Deng

Harnessing slowly varying or quasi-static magnetic fields, which typically lack the power to light an LED, to power devices with higher demands seems to be impossible if no additional power is supplied. Obviously, the key to overcoming this challenge is to achieve passive power conversion from low-power inputs into high-power outputs. Here, we propose that snap-through buckling─a mechanical instability phenomenon─within a magnetoelectric metamaterial enables passive power-up conversion. Our experimental results indicate that the instantaneous pulsed output power at snapping remains stable even as the frequency decreases by 100 times and exceeds the maximum magnetic input power by 27 times at a low working frequency of 0.01 Hz. Furthermore, for an array of magnetoelectric metamaterials with varying critical magnetic fields, we demonstrate that a series of pulsed outputs can result in continuous electrical output. We anticipate that these findings will open new avenues for advanced energy conversion technologies, underscoring a pioneering application of mechanical principles in materials science.

引用次数: 0

Based on Silicon-Gel Polymer Electrolyte Dielectric of Low Impedance Tribovoltaic Nanogenerator

IF 9.5 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces

Pub Date : 2025-02-03 DOI: 10.1021/acsami.4c16954

Zheng Peng, Xiaochuan Li, Haiyang Feng, Xuemei Zhang, Dahu Ren, Qianxi Yang, Hongmei Yang, Jie Chen, Yi Xi

As an innovative renewable energy harvester, the tribovoltaic nanogenerator (TVNG) with lower impedance and DC characteristics has attracted much attention. To alleviate the issues of severe wear for hard–hard semiconductor materials, here, a soft ion dielectric material and semiconductor TVNG based on n-Si/gel polymer electrolyte (GPE) (GPE-TVNG) is proposed. A solid ionic electric double layer (i-EDL) model is established to systematically explore the generation mechanism as well. Moreover, the proposed i-EDL model is verified by subsequent experiments, and the results manifest that the ion directed migration can improve the output performance of GPE-TVNG. The optimized GPE-TVNG has a short-circuit current of 26.5 μA and a low matched impedance of 60 kΩ, which is far lower than the previous reported internal resistance of Si-based TVNG (>100 kΩ). This study broadens the selection of TVNG materials and realizes the effective control of TVNG output.

引用次数: 0

Squaraine-Peptide Conjugates as Efficient Reporters of Neutrophil Extracellular Traps-Mediated Chronic Inflammation

IF 9.5 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces

Pub Date : 2025-02-03 DOI: 10.1021/acsami.4c20658

Sai Kiran Mavileti, Galyna Bila, Valentyn Utka, Rostyslav Bilyy, Jr., Evgenia Bila, Elena Butoi, Shekhar Gupta, Priyanka Balyan, Tamaki Kato, Rostyslav Bilyy, Shyam S. Pandey

The excessive and uncontrolled release of neutrophil extracellular traps (NETs) is increasingly linked to the pathogenesis of various inflammatory diseases, cardiovascular disorders, and cancers. Real-time, non-invasive detection of NETs is crucial for understanding their role in disease progression and developing targeted therapies. Current NETs detection methods often lack the necessary specificity and resolution, particularly in vivo and ex vivo settings. To address this, we have developed novel near-infrared squaraine-peptide conjugates by rational molecular design as reporters of NETosis by targeting the protease activity of neutrophil elastase (NE). These self-quenching, cell-impermeable probes enable the precise real-time detection and imaging of NETs. The Förster resonance energy transfer (FRET)-based probe, Hetero-APA, demonstrated high specificity in detecting NETs in vitro and in vivo, generating strong fluorescence in NETs-rich environments. To overcome the limitations of FRET-based probes for ex vivo imaging, we designed SQ-215-NETP, a non-FRET-based probe that covalently binds to the NE. SQ-215-NETP achieved an unprecedented imaging resolution of 90 nm/pixel in human coronary thrombi, marking the first report of such high resolution with a low molecular weight probe. Additionally, SQ-215-NETP effectively detected NETs by flow cytometry. These results highlight the potential of these probes in NETosis detection, offering promising tools for enhanced diagnostics and therapeutic strategies in managing NET-mediated inflammatory diseases and cancers.

{"title":"Squaraine-Peptide Conjugates as Efficient Reporters of Neutrophil Extracellular Traps-Mediated Chronic Inflammation","authors":"Sai Kiran Mavileti, Galyna Bila, Valentyn Utka, Rostyslav Bilyy, Jr., Evgenia Bila, Elena Butoi, Shekhar Gupta, Priyanka Balyan, Tamaki Kato, Rostyslav Bilyy, Shyam S. Pandey","doi":"10.1021/acsami.4c20658","DOIUrl":"https://doi.org/10.1021/acsami.4c20658","url":null,"abstract":"The excessive and uncontrolled release of neutrophil extracellular traps (NETs) is increasingly linked to the pathogenesis of various inflammatory diseases, cardiovascular disorders, and cancers. Real-time, non-invasive detection of NETs is crucial for understanding their role in disease progression and developing targeted therapies. Current NETs detection methods often lack the necessary specificity and resolution, particularly in vivo and ex vivo settings. To address this, we have developed novel near-infrared squaraine-peptide conjugates by rational molecular design as reporters of NETosis by targeting the protease activity of neutrophil elastase (NE). These self-quenching, cell-impermeable probes enable the precise real-time detection and imaging of NETs. The Förster resonance energy transfer (FRET)-based probe, Hetero-APA, demonstrated high specificity in detecting NETs in vitro and in vivo, generating strong fluorescence in NETs-rich environments. To overcome the limitations of FRET-based probes for ex vivo imaging, we designed SQ-215-NETP, a non-FRET-based probe that covalently binds to the NE. SQ-215-NETP achieved an unprecedented imaging resolution of 90 nm/pixel in human coronary thrombi, marking the first report of such high resolution with a low molecular weight probe. Additionally, SQ-215-NETP effectively detected NETs by flow cytometry. These results highlight the potential of these probes in NETosis detection, offering promising tools for enhanced diagnostics and therapeutic strategies in managing NET-mediated inflammatory diseases and cancers.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"6 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the Performance of Metal-Supported Solid Oxide Fuel Cells via Infiltration with an Aqueous Solution of Metal Nitrate Salts

IF 9.5 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces

Pub Date : 2025-02-03 DOI: 10.1021/acsami.4c19043

Aroosa Javed, Daniel Sikstrom, Yoshihisa Furuya, Nilesh Dale, A. Mohammed Hussain, Venkataraman Thangadurai

The infiltration technique is a cost-effective method to develop nanostructured electrodes that can accelerate sluggish oxygen reduction reaction (ORR) and enhance the electrochemical performance of solid oxide fuel cells (SOFCs) at intermediate temperatures (600–800 °C). For metal-supported SOFCs, identifying a highly efficient ORR catalyst is an ongoing challenge due to lower temperature operation. In this work, nanostructured praseodymium oxide (PrO_x) and multiphase heterostructures containing perovskites with the nominal composition of Nd_0.6Sr_0.4CoO_3−δ (NSC), SrCO_3, and CoO have been developed via infiltration into the symmetric metal-supported backbone as binary layer composite, and their electrochemical performance has been investigated. The composite demonstrates enhanced electrochemical performance at various temperatures achieving the lowest polarization resistance (R_p) of 0.05 Ω cm² at 700 °C compared to multiphase NSC alone (0.1 Ω cm²) under similar conditions. A distribution function of relaxation time (DFRT) analysis using impedance spectroscopy genetic program (ISGP) was carried out to study different electrochemical processes. PrO_x significantly improves the processes involved in the ORR. The full cell performance of the composite electrode achieves a peak power density (PPD) of 329 mW·cm^–2 at 700 °C in 3%H₂O/H₂ as fuel.

{"title":"Enhancing the Performance of Metal-Supported Solid Oxide Fuel Cells via Infiltration with an Aqueous Solution of Metal Nitrate Salts","authors":"Aroosa Javed, Daniel Sikstrom, Yoshihisa Furuya, Nilesh Dale, A. Mohammed Hussain, Venkataraman Thangadurai","doi":"10.1021/acsami.4c19043","DOIUrl":"https://doi.org/10.1021/acsami.4c19043","url":null,"abstract":"The infiltration technique is a cost-effective method to develop nanostructured electrodes that can accelerate sluggish oxygen reduction reaction (ORR) and enhance the electrochemical performance of solid oxide fuel cells (SOFCs) at intermediate temperatures (600–800 °C). For metal-supported SOFCs, identifying a highly efficient ORR catalyst is an ongoing challenge due to lower temperature operation. In this work, nanostructured praseodymium oxide (PrOx) and multiphase heterostructures containing perovskites with the nominal composition of Nd0.6Sr0.4CoO3−δ (NSC), SrCO3, and CoO have been developed via infiltration into the symmetric metal-supported backbone as binary layer composite, and their electrochemical performance has been investigated. The composite demonstrates enhanced electrochemical performance at various temperatures achieving the lowest polarization resistance (Rp) of 0.05 Ω cm2 at 700 °C compared to multiphase NSC alone (0.1 Ω cm2) under similar conditions. A distribution function of relaxation time (DFRT) analysis using impedance spectroscopy genetic program (ISGP) was carried out to study different electrochemical processes. PrOx significantly improves the processes involved in the ORR. The full cell performance of the composite electrode achieves a peak power density (PPD) of 329 mW·cm–2 at 700 °C in 3%H2O/H2 as fuel.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"168 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cu-TCPP Metal–Organic Nanosheets Embedded Thin-Film Composite Membranes for Enhanced Cyanide Detection and Removal: A Multifunctional Approach to Water Treatment and Environmental Safety

IF 9.5 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces

Pub Date : 2025-02-02 DOI: 10.1021/acsami.4c18944

Upendar Reddy Gandra, Ravi P. Pandey, L. Palanikumar, Ahamad Irfan, Mazin Magzoub, Youssef Belmabkhout, Shadi W. Hasan, M. Infas Haja Mohideen

Cyanide is highly toxic, with widespread industrial use posing serious environmental risks. Effective materials for detecting and filtering cyanide from water are urgently needed. This study introduces a novel approach utilizing Cu-TCPP (TCPP = o-tetra(4-carboxyphenyl)porphine) metal–organic nanosheets (MONS) embedded in thin-film composite membranes, offering a multifunctional solution for cyanide detection and filtration. Ultrathin Cu-TCPP MONs were synthesized using a surfactant-assisted method featuring highly accessible metal centers that enhance cyanide interaction and detection. The membranes, developed by modifying cellulose acetate (CA) with Cu-TCPP MONs, demonstrated exceptional performance for cyanide removal. The 6% Cu-TCPP/CA membrane exhibited a 2.3-fold increase in pure water permeability and achieved a cyanide removal efficiency of 94.68%, significantly outperforming the pristine 0% Cu-TCPP/CA membrane (Pure Water Permeability (PWP) = 380.83 L m^–2 h^–1 bar^–1; CN^– removal = 5.01%). This is the first report describing the detection and removal of CN^– in water using the membrane technique in literature. In addition to its removal efficiency, the Cu-TCPP MONs showed remarkable detection capabilities, with a calculated limit of detection of 1.76 × 10^–7 M, surpassing World Health Organization (WHO) and United States Environmental Protection Agency (EPA) safety standards for cyanide levels in water. Additionally, Cu-TCPP MONs, a bioimaging agent with excellent cell viability, were deployed to detect CN^– in MiaPaCa-2 cells, detecting concentrations as low as 0.1 ppm.

{"title":"Cu-TCPP Metal–Organic Nanosheets Embedded Thin-Film Composite Membranes for Enhanced Cyanide Detection and Removal: A Multifunctional Approach to Water Treatment and Environmental Safety","authors":"Upendar Reddy Gandra, Ravi P. Pandey, L. Palanikumar, Ahamad Irfan, Mazin Magzoub, Youssef Belmabkhout, Shadi W. Hasan, M. Infas Haja Mohideen","doi":"10.1021/acsami.4c18944","DOIUrl":"https://doi.org/10.1021/acsami.4c18944","url":null,"abstract":"Cyanide is highly toxic, with widespread industrial use posing serious environmental risks. Effective materials for detecting and filtering cyanide from water are urgently needed. This study introduces a novel approach utilizing Cu-TCPP (TCPP = o-tetra(4-carboxyphenyl)porphine) metal–organic nanosheets (MONS) embedded in thin-film composite membranes, offering a multifunctional solution for cyanide detection and filtration. Ultrathin Cu-TCPP MONs were synthesized using a surfactant-assisted method featuring highly accessible metal centers that enhance cyanide interaction and detection. The membranes, developed by modifying cellulose acetate (CA) with Cu-TCPP MONs, demonstrated exceptional performance for cyanide removal. The 6% Cu-TCPP/CA membrane exhibited a 2.3-fold increase in pure water permeability and achieved a cyanide removal efficiency of 94.68%, significantly outperforming the pristine 0% Cu-TCPP/CA membrane (Pure Water Permeability (PWP) = 380.83 L m–2 h–1 bar–1; CN– removal = 5.01%). This is the first report describing the detection and removal of CN– in water using the membrane technique in literature. In addition to its removal efficiency, the Cu-TCPP MONs showed remarkable detection capabilities, with a calculated limit of detection of 1.76 × 10–7 M, surpassing World Health Organization (WHO) and United States Environmental Protection Agency (EPA) safety standards for cyanide levels in water. Additionally, Cu-TCPP MONs, a bioimaging agent with excellent cell viability, were deployed to detect CN– in MiaPaCa-2 cells, detecting concentrations as low as 0.1 ppm.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"28 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted and Synergistic Codelivery of Chemotherapeutic and Nucleic Acid Drugs by Liposome-Coated MPDA Nanoparticles for Advanced Prostate Cancer Treatment

IF 9.5 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces

Pub Date : 2025-02-02 DOI: 10.1021/acsami.4c17384

Liang Dai, Wangteng Ma, Zixuan Song, Binwei Lu, Yuchu He, Jidong Zhang, Dapeng Wei, Baibing Wang, Guangming Li, Dawei Gao, Yimin Wang

Docetaxel (DTX)-based chemotherapy is the primary therapeutic approach for advanced prostate cancer (PCa) when endocrine therapy proves ineffective. Traditional chemotherapy exhibits poor specificity and induces severe side effects, such as immunosuppression, neurotoxicity, and hypersensitivity. In this study, we aimed to develop a new targeted nanodrug delivery system to accurately identify PCa cells and deliver drugs. We prepared mesoporous polydopamine (MPDA) nanoparticles using a one-pot method. After loading DTX onto MPDA, siRNA was attached to the surface, which was coated with polyethylene glycol lipids film (PEG-Lips); together, this formed MDS@L. The aptamer A10-3.2 was coupled to the surface of PEG-Lips to obtain MDS@LA, which was characterized using different techniques, including transmission electron microscopy and Fourier transform infrared spectroscopy. MDS@LA exhibited excellent stability, acid-responsive release, and photothermal properties, enhancing its antitumor effects. Both in vitro and in vivo experiments revealed that MDS@LA precisely targeted PCa cells and effectively delivered DTX and siRNA, leading to significant inhibition of PCa cell growth and proliferation. This versatile nanoplatform offers a promising, precise, and efficient therapeutic approach for advanced PCa, addressing the limitations of conventional chemotherapy.

{"title":"Targeted and Synergistic Codelivery of Chemotherapeutic and Nucleic Acid Drugs by Liposome-Coated MPDA Nanoparticles for Advanced Prostate Cancer Treatment","authors":"Liang Dai, Wangteng Ma, Zixuan Song, Binwei Lu, Yuchu He, Jidong Zhang, Dapeng Wei, Baibing Wang, Guangming Li, Dawei Gao, Yimin Wang","doi":"10.1021/acsami.4c17384","DOIUrl":"https://doi.org/10.1021/acsami.4c17384","url":null,"abstract":"Docetaxel (DTX)-based chemotherapy is the primary therapeutic approach for advanced prostate cancer (PCa) when endocrine therapy proves ineffective. Traditional chemotherapy exhibits poor specificity and induces severe side effects, such as immunosuppression, neurotoxicity, and hypersensitivity. In this study, we aimed to develop a new targeted nanodrug delivery system to accurately identify PCa cells and deliver drugs. We prepared mesoporous polydopamine (MPDA) nanoparticles using a one-pot method. After loading DTX onto MPDA, siRNA was attached to the surface, which was coated with polyethylene glycol lipids film (PEG-Lips); together, this formed MDS@L. The aptamer A10-3.2 was coupled to the surface of PEG-Lips to obtain MDS@LA, which was characterized using different techniques, including transmission electron microscopy and Fourier transform infrared spectroscopy. MDS@LA exhibited excellent stability, acid-responsive release, and photothermal properties, enhancing its antitumor effects. Both in vitro and in vivo experiments revealed that MDS@LA precisely targeted PCa cells and effectively delivered DTX and siRNA, leading to significant inhibition of PCa cell growth and proliferation. This versatile nanoplatform offers a promising, precise, and efficient therapeutic approach for advanced PCa, addressing the limitations of conventional chemotherapy.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"23 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly Transparent, Spectrally Selective Power-Generating Windows Based on WO3–x Nanorods and Carbon Dots for Full-Spectrum Utilization

IF 9.5 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces

Pub Date : 2025-02-02 DOI: 10.1021/acsami.4c19629

Xianglong Zhao, Yueling Lai, Kanghui Zheng, Qianqian Song, Lianju Wang, Yiqing Chen, Hao Chen, Ruilin Wang, Yufeng Zhou

Near-infrared (NIR) shielding windows can selectively regulate excess solar radiation to reduce heating and cooling energy consumption in a built environment. However, the dissipation of ultraviolet (UV) and visible light into waste heat is inevitable, leading to inefficient solar energy utilization. Herein, a tandem spectrally selective power-generating (SSPG) window is developed by incorporating oxygen-deficient tungsten oxide WO_3–x nanorod-based NIR shielding windows and red-emissive carbon dot-based luminescent solar concentrators (LSCs) to realize full-spectrum utilization. Semitransparent NIR shielding modules absorb NIR light to reduce indoor thermal radiation, while a semitransparent LSC coupled with a photovoltaic system converts UV and partially visible light into electricity. The SSPG window exhibits a visible light transmittance of up to 70.44% and power conversion efficiency of 0.31%, while effectively reducing the indoor temperature by 7 °C under sunlight irradiation. In addition, this SSPG window has good thermal-/photostability and excellent NIR shielding performance after heat treatment and UV irradiation. This work may provide a new avenue for the development of energy-saving windows.

{"title":"Highly Transparent, Spectrally Selective Power-Generating Windows Based on WO3–x Nanorods and Carbon Dots for Full-Spectrum Utilization","authors":"Xianglong Zhao, Yueling Lai, Kanghui Zheng, Qianqian Song, Lianju Wang, Yiqing Chen, Hao Chen, Ruilin Wang, Yufeng Zhou","doi":"10.1021/acsami.4c19629","DOIUrl":"https://doi.org/10.1021/acsami.4c19629","url":null,"abstract":"Near-infrared (NIR) shielding windows can selectively regulate excess solar radiation to reduce heating and cooling energy consumption in a built environment. However, the dissipation of ultraviolet (UV) and visible light into waste heat is inevitable, leading to inefficient solar energy utilization. Herein, a tandem spectrally selective power-generating (SSPG) window is developed by incorporating oxygen-deficient tungsten oxide WO3–x nanorod-based NIR shielding windows and red-emissive carbon dot-based luminescent solar concentrators (LSCs) to realize full-spectrum utilization. Semitransparent NIR shielding modules absorb NIR light to reduce indoor thermal radiation, while a semitransparent LSC coupled with a photovoltaic system converts UV and partially visible light into electricity. The SSPG window exhibits a visible light transmittance of up to 70.44% and power conversion efficiency of 0.31%, while effectively reducing the indoor temperature by 7 °C under sunlight irradiation. In addition, this SSPG window has good thermal-/photostability and excellent NIR shielding performance after heat treatment and UV irradiation. This work may provide a new avenue for the development of energy-saving windows.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"38 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Strain/Pressure Sensor Based on Ag@Polydopamine Nanohybrid Methacrylamide Chitosan/Polyacrylamide Hydrogel for Healthcare Monitoring.

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces

Pub Date : 2025-02-02 DOI: 10.1021/acsami.4c20994

Gaoyi Wu, Wei Shi, Moran Liu, Lixin Liang, Tao Wang, Jinyong Zhang, Jing Chen, Yongsheng Liang, Wei Tang, Hui Li

Hydrogels have emerged as promising candidates for flexible sensors due to their softness, biocompatibility, and tunable physicochemical properties. However, achieving synchronous satisfaction of conformality, conductivity, and diverse biological functions in hydrogel sensors remains a challenge. Here, we proposed a multifunctional hydrogel sensor by incorporating silver-loaded polydopamine nanoparticles (Ag@PDA) into a thermally cross-linked methacrylamide chitosan (CSMA) and acrylamide network, namely, Ag@PDA/(CSMA-PAM). The Ag@PDA/(CSMA-PAM) hydrogel showed the capability to respond effectively to both strain and pressure, enabling its independent application as either a strain sensor or a pressure sensor. The sensitivity of the hydrogel can reach 2.13 within the strain range of 65 to 150%, exhibiting a response and recovery time of 550 ms when utilized as a strain sensor. In contrast, its sensitivity was 0.07 kPa^-1 during pressures ranging from 0 to 2.15 kPa, with a response and recovery time of 136 ms when employed as a pressure sensor. Additionally, the hydrogel sensor demonstrated high linearity (0.998 for strain and 0.98 for pressure), stable cycling ability (500 cycles), and low detection limit (0.5% for strain and 150 Pa for pressure). Moreover, the Ag@PDA/(CSMA-PAM) hydrogel exhibited good stability and reliability for a variety of practical applications, including the detection of subtle and large deformations, as well as real-time physiological activity monitoring. Further, owing to the bioactive components of chitosan and Ag@PDA present in the hydrogel, the Ag@PDA/(CSMA-PAM) sensor exhibited satisfactory biocompatibility along with excellent antioxidant and antibacterial activities, making it highly promising for applications as wearable sensors in personalized healthcare.

{"title":"Multifunctional Strain/Pressure Sensor Based on Ag@Polydopamine Nanohybrid Methacrylamide Chitosan/Polyacrylamide Hydrogel for Healthcare Monitoring.","authors":"Gaoyi Wu, Wei Shi, Moran Liu, Lixin Liang, Tao Wang, Jinyong Zhang, Jing Chen, Yongsheng Liang, Wei Tang, Hui Li","doi":"10.1021/acsami.4c20994","DOIUrl":"https://doi.org/10.1021/acsami.4c20994","url":null,"abstract":"Hydrogels have emerged as promising candidates for flexible sensors due to their softness, biocompatibility, and tunable physicochemical properties. However, achieving synchronous satisfaction of conformality, conductivity, and diverse biological functions in hydrogel sensors remains a challenge. Here, we proposed a multifunctional hydrogel sensor by incorporating silver-loaded polydopamine nanoparticles (Ag@PDA) into a thermally cross-linked methacrylamide chitosan (CSMA) and acrylamide network, namely, Ag@PDA/(CSMA-PAM). The Ag@PDA/(CSMA-PAM) hydrogel showed the capability to respond effectively to both strain and pressure, enabling its independent application as either a strain sensor or a pressure sensor. The sensitivity of the hydrogel can reach 2.13 within the strain range of 65 to 150%, exhibiting a response and recovery time of 550 ms when utilized as a strain sensor. In contrast, its sensitivity was 0.07 kPa-1 during pressures ranging from 0 to 2.15 kPa, with a response and recovery time of 136 ms when employed as a pressure sensor. Additionally, the hydrogel sensor demonstrated high linearity (0.998 for strain and 0.98 for pressure), stable cycling ability (500 cycles), and low detection limit (0.5% for strain and 150 Pa for pressure). Moreover, the Ag@PDA/(CSMA-PAM) hydrogel exhibited good stability and reliability for a variety of practical applications, including the detection of subtle and large deformations, as well as real-time physiological activity monitoring. Further, owing to the bioactive components of chitosan and Ag@PDA present in the hydrogel, the Ag@PDA/(CSMA-PAM) sensor exhibited satisfactory biocompatibility along with excellent antioxidant and antibacterial activities, making it highly promising for applications as wearable sensors in personalized healthcare.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arginine-Rich Peptides Regulate the Pathogenic Galectin-10 Crystallization and Mitigate Crystallopathy-Associated Inflammation

IF 9.5 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces

Pub Date : 2025-02-02 DOI: 10.1021/acsami.4c18411

Wenbo Zhang, Shuyuan Li, Yang Wang, Shuli Liu, Lei Liu, Zhun Deng, Shanshan Mo, Mingrui Chen, Zhenyan Li, Ruonan Wang, Xin Zhou, Longxin Xu, Lanlan Yu, Zhenlin Liu, Hongwei Li, Junbo Liang, Chenxuan Wang

Protein self-assembly into a crystal in vivo triggers acute or chronic organ injury that can lead to intractable diseases lacking specific treatment options. In this study, we report the discovery of ionic arginine-rich peptides to disrupt the pathogenic galectin-10 (gal-10) crystallization, where the aberrant deposition of gal-10 crystals in airways causes the activation of IL-1β-dependent inflammation and the stimulation of epithelial cells to produce TNF-α. Gal-10 crystals show susceptibility to pH changes and charged residue substitutions at the protein packing interfaces, manifesting the role of charge–charge attractions across protein–protein interaction interfaces in governing gal-10 crystallization. To dissolve the gal-10 crystal, the ionic peptides R9 and R12Y8 were identified to eliminate the interprotein charge–charge interactions. The efficacy of R12Y8 in mitigating the gal-10 crystallopathy in vivo was assessed in a crystal-induced lung inflammation mice model. The mice intratracheally administrated by R12Y8 exhibited a downregulated release of proinflammatory cytokines and reduced infiltration of inflammatory cells in the lungs. Our study demonstrates that the pathogenic gal-10 crystallization is readily eliminated by R-rich peptides, which may display translational potentials for the treatment of gal-10 crystallopathy.

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引用次数: 0

Near-Perfect Purification of 2,6-Xylenol from Ternary Cresol Mixtures Using Cucurbit[7]uril.

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces

Pub Date : 2025-02-02 DOI: 10.1021/acsami.5c00654

Xin Lu, Tao Hou, Zhu Tao, Qing Li

The separation of m-cresol (m-cre), p-cresol (p-cre), and 2,6-xylenol (2,6-xyl) poses a significant challenge in industrial processes. This study focuses on selectively separating m-cre and p-cre from a ternary mixture using a cucurbit[7]uril (Q[7]) aqueous solution to achieve the near-perfect purification of 2,6-xyl. Experimental results show that m-cre and p-cre can be selectively encapsulated by the Q[7] host, while 2,6-xyl, due to its larger volume, cannot be encapsulated. The synergistic effect of steric hindrance and complex stability contributes to effective host-guest selective encapsulation separation. The Q[7] aqueous solution can be easily recovered and reused without a significant decrease in separation performance. In the simulated industrial separation experiment, the purity of the purified cresol reached 100%. This research underscores the importance of macrocyclic host molecules in enhancing industrial separations and reducing energy costs through precise guest molecule recognition.

引用次数: 0

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