Background: In Ethiopia, the maternal death is still unacceptably high, but instead of women dying in their 'hovels', they die in hospitals. For improving quality of medical care in obstetric emergencies, appropriate timing is extremely important and key to reduce maternal mortality. The aim of the study was to assess delay in receiving adequate and appropriate treatment for women faced emergency obstetric complications admitted to emergency room on five referral hospitals of Ethiopia. Methods: Facility based Cross-sectional study was conducted on five referral hospitals of Ethiopia. Mixed of health facilities (university and non-university hospitals) that provide specialized obstetric care and perform a minimum number of 1,000 deliveries per year was considered. Women faced obstetric complications and fulfill world Health Organizations Criteria for potential life-threatening conditions was included in the study. A total of 360 study subjects were sampled. Samples was proportionally allocated to each facilities based on their clients flow and systematic random sampling technique was used to select study subjects. Data was collected using exist interview and from maternal cards. Data was analyzed using SPSS software. Multivariable analysis was conducted using logistic regression; variables with the largest p-value of 0.2 in bivariable analysis were included. Result: The mean age of the respondent was 30 year with standard deviation of (SD , ± 6). Out of the total sampled, 60% of them faced obstetric complications at home. Even though, the time of getting appropriate treatment for a women faced obstetric complications vary from complication to complication they faced, but the median time were 1.10 hours. About 49 percent of women faced obstetric complications were delayed to get appropriate treatment which was above the median time. Of which, one in six women were delayed to received appropriate treatment because of training issues. women who got information about emergency obstetric complications were two times more likely to reduce delay in receiving appropriate treatment than women who did not get the information (AOR: 2.09, 95% CI, 1.0-4.36). Conclusion : About 49 percent of women were delayed in receiving appropriate treatment, and women who were got information about emergency obstetric complications were got appropriate treatment on time. Therefore referral hospitals of Ethiopia, are recommended to check there liaison system and emergency medical management protocols. Keywords : Emergency obstetric care, Multivariable analysis, SPSS software, Third delay
{"title":"Assessing Delay in Receiving Adequate and Appropriate Treatment: A Client Perspective among Women Admitted to Emergency Obstetric Hospitals of Ethiopia","authors":"Gedamu Abera Zegeye","doi":"10.37628/IJBME.V6I2.750","DOIUrl":"https://doi.org/10.37628/IJBME.V6I2.750","url":null,"abstract":"Background: In Ethiopia, the maternal death is still unacceptably high, but instead of women dying in their 'hovels', they die in hospitals. For improving quality of medical care in obstetric emergencies, appropriate timing is extremely important and key to reduce maternal mortality. The aim of the study was to assess delay in receiving adequate and appropriate treatment for women faced emergency obstetric complications admitted to emergency room on five referral hospitals of Ethiopia. Methods: Facility based Cross-sectional study was conducted on five referral hospitals of Ethiopia. Mixed of health facilities (university and non-university hospitals) that provide specialized obstetric care and perform a minimum number of 1,000 deliveries per year was considered. Women faced obstetric complications and fulfill world Health Organizations Criteria for potential life-threatening conditions was included in the study. A total of 360 study subjects were sampled. Samples was proportionally allocated to each facilities based on their clients flow and systematic random sampling technique was used to select study subjects. Data was collected using exist interview and from maternal cards. Data was analyzed using SPSS software. Multivariable analysis was conducted using logistic regression; variables with the largest p-value of 0.2 in bivariable analysis were included. Result: The mean age of the respondent was 30 year with standard deviation of (SD , ± 6). Out of the total sampled, 60% of them faced obstetric complications at home. Even though, the time of getting appropriate treatment for a women faced obstetric complications vary from complication to complication they faced, but the median time were 1.10 hours. About 49 percent of women faced obstetric complications were delayed to get appropriate treatment which was above the median time. Of which, one in six women were delayed to received appropriate treatment because of training issues. women who got information about emergency obstetric complications were two times more likely to reduce delay in receiving appropriate treatment than women who did not get the information (AOR: 2.09, 95% CI, 1.0-4.36). Conclusion : About 49 percent of women were delayed in receiving appropriate treatment, and women who were got information about emergency obstetric complications were got appropriate treatment on time. Therefore referral hospitals of Ethiopia, are recommended to check there liaison system and emergency medical management protocols. Keywords : Emergency obstetric care, Multivariable analysis, SPSS software, Third delay","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69924335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nature of Obstetric Emergency Health Services in India","authors":"S. Kaur, Manpreet Kaur","doi":"10.37628/IJBME.V6I2.749","DOIUrl":"https://doi.org/10.37628/IJBME.V6I2.749","url":null,"abstract":"","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69924273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-28DOI: 10.3760/CMA.J.ISSN.1673-4181.2019.06.013
Liang Tang
Colorectal cancer (CRC) is one of the most common human malignant diseases, the cumulative result of genetic and epigenetic mutations, and its mortality rate is second only to that of lung cancer. Most patients with CRC have developed to middle to advanced stage when symptoms appear, and the treatment effects of surgery and chemotherapy are usually not satisfactory. With the emergence of targeted drugs in recent years, individualized treatment of colorectal cancer has gradually become a trend. With the development of colorectal cancer research, more and more molecular markers of colorectal cancer have been continuously discovered, and its impact on tumorigenesis, development and treatment has gradually received more attention. The application of molecular markers in the screening of colorectal cancer can help the early detection and diagnosis. Detection of molecular markers before individualized treatment can optimize the treatment plan and prompt the patient's prognosis. In this paper, the most recent findings of molecular markers with promising clinical application were summarized, in order to provide reference for the early diagnosis and treatment of colorectal cancer. Key words: Colorectal cancer; Biomarker; CpG island methylator phenotype; Oncogene; Tumor suppressor gene
{"title":"Research progress of biomarkers in diagnosis and therapy of colorectal cancer","authors":"Liang Tang","doi":"10.3760/CMA.J.ISSN.1673-4181.2019.06.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2019.06.013","url":null,"abstract":"Colorectal cancer (CRC) is one of the most common human malignant diseases, the cumulative result of genetic and epigenetic mutations, and its mortality rate is second only to that of lung cancer. Most patients with CRC have developed to middle to advanced stage when symptoms appear, and the treatment effects of surgery and chemotherapy are usually not satisfactory. With the emergence of targeted drugs in recent years, individualized treatment of colorectal cancer has gradually become a trend. With the development of colorectal cancer research, more and more molecular markers of colorectal cancer have been continuously discovered, and its impact on tumorigenesis, development and treatment has gradually received more attention. The application of molecular markers in the screening of colorectal cancer can help the early detection and diagnosis. Detection of molecular markers before individualized treatment can optimize the treatment plan and prompt the patient's prognosis. In this paper, the most recent findings of molecular markers with promising clinical application were summarized, in order to provide reference for the early diagnosis and treatment of colorectal cancer. \u0000 \u0000 \u0000Key words: \u0000Colorectal cancer; Biomarker; CpG island methylator phenotype; Oncogene; Tumor suppressor gene","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46862781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-28DOI: 10.3760/CMA.J.ISSN.1673-4181.2019.06.011
Qi Li, Qi Wu, Na-xin Zhang
Objective To study the clinical application value of long term home noninvasive positive pressure ventilation in the therapy of silicosis patients with type 2 respiratory failure. Methods A total of 85 silicosis patients with type 2 respiratory failure were enrolled, and their clinical data were retrospectively analyzed. According to the therapeutic method, they were divided into noninvasive positive pressure ventilation group (group A) and basic therapy group (group B). The various indicators of the patients were analyzed before and after the treatment including vital signs, laboratory indicators, 6-minute walking distance (6MWD), and modified dyspnea index (mMRC). The admission times, length of hospital stay and annual mortality of the patients were also recorded by follow-up after the treatment for one year. Results After the one year follow-up, the heart rate, respiratory rate, PaO2, PaCO2, SO2%, 6MWD, and mMRC of group A were significantly improved than those of group B (all P 0.05). Conclusions The therapeutic method of home noninvasive positive pressure ventilation has significant effects on silicosis combined with type 2 respiratory failure. It can improve clinical symptoms and the quality of life, and reduce the length of hospital stay and admission times, and reduced medical insurance burden. Key words: Home; Noninvasive positive pressure ventilation; Silicosis; Type 2 respiratory failure
{"title":"Clinical study of home noninvasive positive pressure ventilation treatment of silicosis patients with respiratory failure","authors":"Qi Li, Qi Wu, Na-xin Zhang","doi":"10.3760/CMA.J.ISSN.1673-4181.2019.06.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2019.06.011","url":null,"abstract":"Objective \u0000To study the clinical application value of long term home noninvasive positive pressure ventilation in the therapy of silicosis patients with type 2 respiratory failure. \u0000 \u0000 \u0000Methods \u0000A total of 85 silicosis patients with type 2 respiratory failure were enrolled, and their clinical data were retrospectively analyzed. According to the therapeutic method, they were divided into noninvasive positive pressure ventilation group (group A) and basic therapy group (group B). The various indicators of the patients were analyzed before and after the treatment including vital signs, laboratory indicators, 6-minute walking distance (6MWD), and modified dyspnea index (mMRC). The admission times, length of hospital stay and annual mortality of the patients were also recorded by follow-up after the treatment for one year. \u0000 \u0000 \u0000Results \u0000After the one year follow-up, the heart rate, respiratory rate, PaO2, PaCO2, SO2%, 6MWD, and mMRC of group A were significantly improved than those of group B (all P 0.05). \u0000 \u0000 \u0000Conclusions \u0000The therapeutic method of home noninvasive positive pressure ventilation has significant effects on silicosis combined with type 2 respiratory failure. It can improve clinical symptoms and the quality of life, and reduce the length of hospital stay and admission times, and reduced medical insurance burden. \u0000 \u0000 \u0000Key words: \u0000Home; Noninvasive positive pressure ventilation; Silicosis; Type 2 respiratory failure","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49108157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-28DOI: 10.3760/CMA.J.ISSN.1673-4181.2019.06.006
Yi Liu, Hua Fan, Huihui Wang, B. Zhang, Jing-ming Zhai, Yonggang Fan
Objective To study the expression of kinesin family member C1 (KIFC1) in hepatocellular carcinoma (HCC) and analyze its correlation with the clinicopathological features and prognosis of patients. Methods The expression levels of KIFC1 protein in the HCC tissues from 82 patients were determined by immunohistochemical staining. The correlation between KIFC1 protein and clinicopathological characteristics (including age, gender, tumor nodules, tumor grade, tumor volume, lymph node metastasis, and alpha-fetoprotein expression) was analyzed. The Kaplan-Meier analysis was used to analyze the effect of KIFC1 expression level on overall survival and progression-free survival in patients with HCC. The expression level of KIFC1 mRNA in liver cancer tissue was analyzed by GPEIA database. The correlation between KIFC1 expression and prognosis was analyzed by KM-plotter. Results KIFC1 protein is significantly overexpressed in liver cancer tissues, and its expression level is significantly correlated with tumor nodule number (P=0.023) and tumor size (P=0.011). Patients with high expression of KIFC1 had poor overall disease and disease-free survival (all P<0.05). KIFC1 mRNA is significantly overexpressed in liver cancer tissues and correlated with disease-free survival and overall survival. Conclusions The expression of KIFC1 protein is highly expressed in liver cancer tissues, and its expression level is related to the clinicopathological characteristics of liver cancer. Bioinformatics analysis results show that KIFC1 is related to the poor prognosis of patients, suggesting that KIFC1 is expected to be a potential predictor and therapeutic target for liver cancer prognosis. Key words: Hepatocellular carcinoma; Kinesin family member C1; Immunohistochemistry; Clinicopathological features; Prognosis
{"title":"Expression of kinesin family member C1 in hepatocellular carcinoma and its correlation with prognosis and clinicopathological features","authors":"Yi Liu, Hua Fan, Huihui Wang, B. Zhang, Jing-ming Zhai, Yonggang Fan","doi":"10.3760/CMA.J.ISSN.1673-4181.2019.06.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2019.06.006","url":null,"abstract":"Objective \u0000To study the expression of kinesin family member C1 (KIFC1) in hepatocellular carcinoma (HCC) and analyze its correlation with the clinicopathological features and prognosis of patients. \u0000 \u0000 \u0000Methods \u0000The expression levels of KIFC1 protein in the HCC tissues from 82 patients were determined by immunohistochemical staining. The correlation between KIFC1 protein and clinicopathological characteristics (including age, gender, tumor nodules, tumor grade, tumor volume, lymph node metastasis, and alpha-fetoprotein expression) was analyzed. The Kaplan-Meier analysis was used to analyze the effect of KIFC1 expression level on overall survival and progression-free survival in patients with HCC. The expression level of KIFC1 mRNA in liver cancer tissue was analyzed by GPEIA database. The correlation between KIFC1 expression and prognosis was analyzed by KM-plotter. \u0000 \u0000 \u0000Results \u0000KIFC1 protein is significantly overexpressed in liver cancer tissues, and its expression level is significantly correlated with tumor nodule number (P=0.023) and tumor size (P=0.011). Patients with high expression of KIFC1 had poor overall disease and disease-free survival (all P<0.05). KIFC1 mRNA is significantly overexpressed in liver cancer tissues and correlated with disease-free survival and overall survival. \u0000 \u0000 \u0000Conclusions \u0000The expression of KIFC1 protein is highly expressed in liver cancer tissues, and its expression level is related to the clinicopathological characteristics of liver cancer. Bioinformatics analysis results show that KIFC1 is related to the poor prognosis of patients, suggesting that KIFC1 is expected to be a potential predictor and therapeutic target for liver cancer prognosis. \u0000 \u0000 \u0000Key words: \u0000Hepatocellular carcinoma; Kinesin family member C1; Immunohistochemistry; Clinicopathological features; Prognosis","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45917570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-28DOI: 10.3760/CMA.J.ISSN.1673-4181.2019.06.008
Saihui Cui, Hongwang Zhu, Zhenai Pan, Haochen Wang
Objective To compare and analyze the relationship between geometric parameters of the needle of different insulin pens and their puncture force, flow rate, and pressing force. Methods The human skin tissue model and needle model were established, and the finite element simulation analysis of needle puncture was performed. Using a test platform, 25 kinds of needles with different geometric parameters were tested for the puncture force, pushing pressure, flow rate and other parameters. The influence of geometric parameters on the performance of the needles were analyzed. Results The puncture force of the needle was closely related to its section design. Compared with the three-section needle, the five-section needle increases the secondary inclination angle and the condyle angle, increases the contact area between the needle and the tissue, and make the change of the contact angle more smoothly, which reduce the needle penetration force. The smaller the outer diameter of the needle, the smaller the penetrating power. The larger the inner diameter of the needle, the greater the fluid flow rate, the smaller the pushing pressure, and the higher the injection accuracy. Conclusions Five-section, ultra-thin-walled or ultra-thin-walled needles have more excellent performance. On the basis of ensuring the strength of the needle, the needle's geometry can be optimized to reduce the puncture force. The results of this study can provide theoretical basis and experimental basis for the design of needles for insulin pens. Key words: Insulin pen needle; Puncture force; Flow rate; Finite element analysis
{"title":"Finite element analysis and experimental study of the performance of insulin pen needles","authors":"Saihui Cui, Hongwang Zhu, Zhenai Pan, Haochen Wang","doi":"10.3760/CMA.J.ISSN.1673-4181.2019.06.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2019.06.008","url":null,"abstract":"Objective \u0000To compare and analyze the relationship between geometric parameters of the needle of different insulin pens and their puncture force, flow rate, and pressing force. \u0000 \u0000 \u0000Methods \u0000The human skin tissue model and needle model were established, and the finite element simulation analysis of needle puncture was performed. Using a test platform, 25 kinds of needles with different geometric parameters were tested for the puncture force, pushing pressure, flow rate and other parameters. The influence of geometric parameters on the performance of the needles were analyzed. \u0000 \u0000 \u0000Results \u0000The puncture force of the needle was closely related to its section design. Compared with the three-section needle, the five-section needle increases the secondary inclination angle and the condyle angle, increases the contact area between the needle and the tissue, and make the change of the contact angle more smoothly, which reduce the needle penetration force. The smaller the outer diameter of the needle, the smaller the penetrating power. The larger the inner diameter of the needle, the greater the fluid flow rate, the smaller the pushing pressure, and the higher the injection accuracy. \u0000 \u0000 \u0000Conclusions \u0000Five-section, ultra-thin-walled or ultra-thin-walled needles have more excellent performance. On the basis of ensuring the strength of the needle, the needle's geometry can be optimized to reduce the puncture force. The results of this study can provide theoretical basis and experimental basis for the design of needles for insulin pens. \u0000 \u0000 \u0000Key words: \u0000Insulin pen needle; Puncture force; Flow rate; Finite element analysis","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47704848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-28DOI: 10.3760/CMA.J.ISSN.1673-4181.2019.06.009
Jian Kang, Jinrong Zhao, Jing Li, Ying Zhang, Rui-dan Su, Yongqiang Ma, Zhi-Tao Wang
Objective To compare the clinical effects of guided tissue regeneration (GTR) combined with different bone graft materials, including Bio-Gene, Bone3 and Bio-Oss, in the treatment of periodontal intra-bony defects. Methods Eighteen patients with chronic periodontitis with periodontal intra-bony defects were randomly divided into the Bio-Gene group, the Bone3 group and Bio-Oss group. After periodontal debridement, periodontal bone grafting combined with GTR surgery was performed in all patients. The clinical and radiographic parameters of patients were collected before surgery, suture removal (2 weeks after surgery), and 6 months after surgery, including periodontal exploration depth (PD), clinical attachment loss (CAL), gingival recession (GR), and residual alveolar bone height (RBH). Results The wounds healed well in all patients when the suture was removed. The stage I healing was obtained without infection or wound dehiscence, and the postoperative discomfort was acceptable. At 6 months after periodontal bone grafting combined with GTR treatment, the PD and CAL indexes in the three groups were significantly improved compared with those before surgery (all P 0.05). Imaging results showed that new bone formation was observed in the original bone defect area in all three groups after 6 months of the treatment, the bone density was similar to the surrounding bone tissue. Besides, the RBH% increased significantly compared with that before the treatment (all P 0.05). Conclusions Bio-Gene, Bone3 and Bio-Oss are all reliable bone graft materials for the treatment of alveolar bone defects caused by periodontitis, which can significantly improve the osteogenesis effect. Key words: Periodontitis; Intra-bony defects; Periodontal bone grafting; Guided tissue regeneration; Bone substitute
{"title":"Comparison of clinical effects of three kinds of bone graft in the treatment of periodontal intra-bony defects","authors":"Jian Kang, Jinrong Zhao, Jing Li, Ying Zhang, Rui-dan Su, Yongqiang Ma, Zhi-Tao Wang","doi":"10.3760/CMA.J.ISSN.1673-4181.2019.06.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2019.06.009","url":null,"abstract":"Objective \u0000To compare the clinical effects of guided tissue regeneration (GTR) combined with different bone graft materials, including Bio-Gene, Bone3 and Bio-Oss, in the treatment of periodontal intra-bony defects. \u0000 \u0000 \u0000Methods \u0000Eighteen patients with chronic periodontitis with periodontal intra-bony defects were randomly divided into the Bio-Gene group, the Bone3 group and Bio-Oss group. After periodontal debridement, periodontal bone grafting combined with GTR surgery was performed in all patients. The clinical and radiographic parameters of patients were collected before surgery, suture removal (2 weeks after surgery), and 6 months after surgery, including periodontal exploration depth (PD), clinical attachment loss (CAL), gingival recession (GR), and residual alveolar bone height (RBH). \u0000 \u0000 \u0000Results \u0000The wounds healed well in all patients when the suture was removed. The stage I healing was obtained without infection or wound dehiscence, and the postoperative discomfort was acceptable. At 6 months after periodontal bone grafting combined with GTR treatment, the PD and CAL indexes in the three groups were significantly improved compared with those before surgery (all P 0.05). Imaging results showed that new bone formation was observed in the original bone defect area in all three groups after 6 months of the treatment, the bone density was similar to the surrounding bone tissue. Besides, the RBH% increased significantly compared with that before the treatment (all P 0.05). \u0000 \u0000 \u0000Conclusions \u0000Bio-Gene, Bone3 and Bio-Oss are all reliable bone graft materials for the treatment of alveolar bone defects caused by periodontitis, which can significantly improve the osteogenesis effect. \u0000 \u0000 \u0000Key words: \u0000Periodontitis; Intra-bony defects; Periodontal bone grafting; Guided tissue regeneration; Bone substitute","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44305156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-28DOI: 10.3760/CMA.J.ISSN.1673-4181.2019.06.012
Xiaoyue Liang, Zhaohui Zou, Xiaoxi Dong, Ranran Du, Yu Zhang
Objective To analyze the influence of a dental caries phototherapy device using neodymium-yttrium-aluminum-garnet (Nd:YAG) laser on the temperature of tooth pulp chamber of different sites and morphologies under different irradiation duration and power. Methods Fifty intact isolated teeth were collected and randomly divided into middle incisor group, upper right first premolar group, upper right second molar group, upper left first premolar group, and upper left second molar group. Each experimental group was irradiated according to the laser power 1.5, 1.6, 1.7, 1.8, 1.9 and 2.0 W, and the irradiation duration 30, 60, 90 s. The temperature rise of the pulp chamber was recorded with a thermocouple thermometer. Results After the laser irradiation, the temperature of the tooth pulp chamber increased, and the temperature rise was less than 5.5 ℃, i.e. the threshold leading to the dental pulp necrosis. Conclusions The use of laser to prevent dental caries will increase the temperature of the tooth pulp chamber, but the temperature rise in the range of 5.5 ° C is relatively safe and will not cause irreversible damage to the pulp tissue. Key words: Oral phototherapy device; Laser; Pulp chamber; Temperature
{"title":"Nd:YAG Laser therapy device for caries control and prevention and its influence on temperature of isolated tooth pulp chamber","authors":"Xiaoyue Liang, Zhaohui Zou, Xiaoxi Dong, Ranran Du, Yu Zhang","doi":"10.3760/CMA.J.ISSN.1673-4181.2019.06.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2019.06.012","url":null,"abstract":"Objective \u0000To analyze the influence of a dental caries phototherapy device using neodymium-yttrium-aluminum-garnet (Nd:YAG) laser on the temperature of tooth pulp chamber of different sites and morphologies under different irradiation duration and power. \u0000 \u0000 \u0000Methods \u0000Fifty intact isolated teeth were collected and randomly divided into middle incisor group, upper right first premolar group, upper right second molar group, upper left first premolar group, and upper left second molar group. Each experimental group was irradiated according to the laser power 1.5, 1.6, 1.7, 1.8, 1.9 and 2.0 W, and the irradiation duration 30, 60, 90 s. The temperature rise of the pulp chamber was recorded with a thermocouple thermometer. \u0000 \u0000 \u0000Results \u0000After the laser irradiation, the temperature of the tooth pulp chamber increased, and the temperature rise was less than 5.5 ℃, i.e. the threshold leading to the dental pulp necrosis. \u0000 \u0000 \u0000Conclusions \u0000The use of laser to prevent dental caries will increase the temperature of the tooth pulp chamber, but the temperature rise in the range of 5.5 ° C is relatively safe and will not cause irreversible damage to the pulp tissue. \u0000 \u0000 \u0000Key words: \u0000Oral phototherapy device; Laser; Pulp chamber; Temperature","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48586792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-28DOI: 10.3760/CMA.J.ISSN.1673-4181.2019.06.005
Zaiyu Guo, Heliang Zhang, Qian Chen, Yanwei Hou
Objective To study on the role of histone methylation enzyme enhancer of zeste homolog 2 (EHZ2) and vascular endothelial growth factor 165 (VEGF165) in momymoya disease. Methods The animal model of moyamoya disease was established by ear vein injection of horse serum in New Zealand rabbits. VEGF165 was over-expressed in situ by packaging lentivirus. Real-time quantitative PCR and Western Blot were used to detect the expression of VEGF165, EZH2 and H3K27me3 in the brain tissues of the animal models. Results Compared with the normal control group, the expression levels of mRNA and protein of EZH2 in the moyamoya disease model group were increased (EZH2 mRNA: P<0.01), and the level of histone H3K27me3 was increased. After overexpression of VEGF165 in the moyamoya disease model group, the expression levels of mRNA and protein of EZH2 was further increased (EZH2 mRNA: P<0.01), and the level of histone H3K27me3 was also increased. Conclusions EZH2 plays a certain role in the pathogenesis of moyamoya disease, and the expression of EZH2 is regulated by VEGF 165, which provides a theoretical basis for the study of the pathogenesis of moyamoya disease. Key words: Moyamoya disease; Enhancer of zeste homolog 2; Vascular endothelial growth factor 165
{"title":"Role of histone methylation enzyme EZH2 and VEGF165 in momymoya disease","authors":"Zaiyu Guo, Heliang Zhang, Qian Chen, Yanwei Hou","doi":"10.3760/CMA.J.ISSN.1673-4181.2019.06.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2019.06.005","url":null,"abstract":"Objective \u0000To study on the role of histone methylation enzyme enhancer of zeste homolog 2 (EHZ2) and vascular endothelial growth factor 165 (VEGF165) in momymoya disease. \u0000 \u0000 \u0000Methods \u0000The animal model of moyamoya disease was established by ear vein injection of horse serum in New Zealand rabbits. VEGF165 was over-expressed in situ by packaging lentivirus. Real-time quantitative PCR and Western Blot were used to detect the expression of VEGF165, EZH2 and H3K27me3 in the brain tissues of the animal models. \u0000 \u0000 \u0000Results \u0000Compared with the normal control group, the expression levels of mRNA and protein of EZH2 in the moyamoya disease model group were increased (EZH2 mRNA: P<0.01), and the level of histone H3K27me3 was increased. After overexpression of VEGF165 in the moyamoya disease model group, the expression levels of mRNA and protein of EZH2 was further increased (EZH2 mRNA: P<0.01), and the level of histone H3K27me3 was also increased. \u0000 \u0000 \u0000Conclusions \u0000EZH2 plays a certain role in the pathogenesis of moyamoya disease, and the expression of EZH2 is regulated by VEGF 165, which provides a theoretical basis for the study of the pathogenesis of moyamoya disease. \u0000 \u0000 \u0000Key words: \u0000Moyamoya disease; Enhancer of zeste homolog 2; Vascular endothelial growth factor 165","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47449542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-28DOI: 10.3760/CMA.J.ISSN.1673-4181.2019.06.003
Tao Ma, Jia-yi Liang, Junhua Shi
Objective To investigate the effects of tea-polyphenols on diabetic nephropathy (DN) mice by regulating nuclear factor E2-related factor 2/antioxidant response element (Nrf-2/ARE) signaling pathway. Methods A total of ten male 9-week-old normal (db/m) mice were randomly and equally divided into blank control group and tea-polyphenol control group, and ten male 9-week-old homologous type 2 diabetes (db/db) mice were randomly divided into model group and tea polyphenol treatment group. The animals in the tea-polyphenol control group and the treatment group were given 50 mg/(kg·d) tea-polyphenols by oral gavage, and the animals in the blank control group and model group were given same volume of double distilled water. The administration was once a day for 8 weeks. The blood glucose and 24-hour urine protein quantization (24 h-UP) were measured and recorded at 0, 4, and 8 weeks. After 8 weeks of the treatment, the mice were sacrificed. The intraocular blood stasis samples were collected for renal function indicators (serum creatinine and urea nitrogen), and kidney tissue samples were also collected for the tests of superoxide dismutase (SOD), reactive oxygen species, and malondialdehyde. Periodic acid Schiff reaction (PAS) staining was used to observe glomerular injury and scored. Western blot was used to detect the expression of Nrf-2 and hemeoxygenase-1 (HO-1) protein. Results Compared with the blank control group, the blood glucose and 24 h-UP of the mice in the model group and the tea-polyphenol treatment group increased after 4 and 8 weeks of the treatment (all P 0.05). Conclusions Renal tissue of DN mice will undergo significant oxidative stress injury. Tea-polyphenols may reduce the oxidative stress injury in DN mice by regulating the Nrf-2/ARE signaling pathway, and play a protective role in the kidney. Key words: Diabetic nephropathy; Tea-polyphenols; Nuclear factor E2-related factor 2/antioxidant response element signaling pathway; Oxidative stress
{"title":"Effect of tea polyphenols on diabetic nephropathy mice by regulating Nrf-2/ARE signaling pathway","authors":"Tao Ma, Jia-yi Liang, Junhua Shi","doi":"10.3760/CMA.J.ISSN.1673-4181.2019.06.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2019.06.003","url":null,"abstract":"Objective \u0000To investigate the effects of tea-polyphenols on diabetic nephropathy (DN) mice by regulating nuclear factor E2-related factor 2/antioxidant response element (Nrf-2/ARE) signaling pathway. \u0000 \u0000 \u0000Methods \u0000A total of ten male 9-week-old normal (db/m) mice were randomly and equally divided into blank control group and tea-polyphenol control group, and ten male 9-week-old homologous type 2 diabetes (db/db) mice were randomly divided into model group and tea polyphenol treatment group. The animals in the tea-polyphenol control group and the treatment group were given 50 mg/(kg·d) tea-polyphenols by oral gavage, and the animals in the blank control group and model group were given same volume of double distilled water. The administration was once a day for 8 weeks. The blood glucose and 24-hour urine protein quantization (24 h-UP) were measured and recorded at 0, 4, and 8 weeks. After 8 weeks of the treatment, the mice were sacrificed. The intraocular blood stasis samples were collected for renal function indicators (serum creatinine and urea nitrogen), and kidney tissue samples were also collected for the tests of superoxide dismutase (SOD), reactive oxygen species, and malondialdehyde. Periodic acid Schiff reaction (PAS) staining was used to observe glomerular injury and scored. Western blot was used to detect the expression of Nrf-2 and hemeoxygenase-1 (HO-1) protein. \u0000 \u0000 \u0000Results \u0000Compared with the blank control group, the blood glucose and 24 h-UP of the mice in the model group and the tea-polyphenol treatment group increased after 4 and 8 weeks of the treatment (all P 0.05). \u0000 \u0000 \u0000Conclusions \u0000Renal tissue of DN mice will undergo significant oxidative stress injury. Tea-polyphenols may reduce the oxidative stress injury in DN mice by regulating the Nrf-2/ARE signaling pathway, and play a protective role in the kidney. \u0000 \u0000 \u0000Key words: \u0000Diabetic nephropathy; Tea-polyphenols; Nuclear factor E2-related factor 2/antioxidant response element signaling pathway; Oxidative stress","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42850215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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