Journal of Leather Science and Engineering最新文献_第8页

Wrapping collagen-based nanoparticle with macrophage membrane for treating multidrug-resistant bacterial infection 巨噬细胞膜包裹胶原基纳米颗粒治疗多重耐药细菌感染

Journal of Leather Science and Engineering

Pub Date : 2022-12-02 DOI: 10.1186/s42825-022-00106-2

Yuanyuan Li, Jianming Xiong, Yi Hu, Wenjun Miao, He Huang

Nowadays, multidrug-resistant (MDR) bacterial infectious diseases has become a thorny issue in the healthcare field. Owning to its intrinsic merits, photodynamic therapy (PDT) shows tremendous strengths in fighting against MDR bacterial infections. However, most photodynamic nanoplatforms exhibit unsatisfactory targeting efficiency towards bacteria and infection site, which may compromise the bactericidal effect of PDT. Herein, we firstly reported a bacteria-targeted collagen-based nanoparticle, named Ce6/Col/MM, for treating methicillin-resistant Staphylococcus aureus (MRSA)-infected wound. Ce6/Col/MM was fabricated by wrapping chlorin e6 (Ce6)-loaded collagen-based nanoparticles with macrophage membrane (MM), showing excellent photodynamic activity and good biocompatibility. In vitro studies demonstrated that Ce6/Col/MM could target to bacteria and then exhibit prominent antibacterial capacity against planktonic MRSA under light irradiation. Furthermore, the treatment of MRSA-infected wound in mice with Ce6/Col/MM plus light illumination resulted in potent bacterial inactivation and accelerated wound healing, accompanied by favorable histological compatibility. Collectively, Ce6/Col/MM with superior targeting ability towards bacteria, effective photodynamic antibacterial potency and minimal safety concerns, might be a powerful bactericidal nanoagent for treating infections caused by MDR bacteria.

Graphical Abstract

目前，耐多药细菌传染病已成为卫生保健领域的一个棘手问题。光动力疗法(PDT)由于其固有的优点，在对抗耐多药细菌感染方面显示出巨大的优势。然而，大多数光动力纳米平台对细菌和感染部位的靶向效率不理想，这可能会影响PDT的杀菌效果。在此，我们首次报道了一种细菌靶向胶原蛋白纳米颗粒，命名为Ce6/Col/MM，用于治疗耐甲氧西林金黄色葡萄球菌(MRSA)感染的伤口。用巨噬细胞膜(MM)包裹载氯e6 (Ce6)的胶原基纳米颗粒制备Ce6/Col/MM，具有良好的光动力活性和生物相容性。体外实验表明，Ce6/Col/MM可靶向细菌，在光照下对浮游MRSA表现出较强的抑菌能力。此外，用Ce6/Col/MM加光照治疗mrsa感染的小鼠伤口，结果是有效的细菌灭活和加速伤口愈合，并伴有良好的组织相容性。综上所述，Ce6/Col/MM具有优异的细菌靶向能力、有效的光动力抗菌效力和最小的安全性问题，可能成为治疗耐多药细菌感染的强力杀菌纳米剂。图形抽象

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引用次数: 5

Characterization of recombinant humanized collagen type III and its influence on cell behavior and phenotype 重组人源ⅲ型胶原蛋白的表征及其对细胞行为和表型的影响

Journal of Leather Science and Engineering

Pub Date : 2022-12-01 DOI: 10.1186/s42825-022-00103-5

Jing Wang, Hong Hu, Jian Wang, He Qiu, Yongli Gao, Yang Xu, Zhanhong Liu, Yajun Tang, Lu Song, John Ramshaw, Hai Lin, Xingdong Zhang

Collagen made a tremendous impact in the field of regenerative medicine as a bioactive material. For decades, collagen has been used not only as a scaffolding material but also as an active component in regulating cells' biological behavior and phenotype. However, animal-derived collagen as a major source suffered from problems of immunogenicity, risk of viral infection, and the unclear relationship between bioactive sequence and function. Recombinant humanized collagen (rhCol) provided alternatives for regenerative medicine with more controllable risks. However, the characterization of rhCol and the interaction between rhCol and cells still need further investigation, including cell behavior and phenotype. The current study preliminarily demonstrated that recombinant humanized collagen type III (rhCol III) conformed to the theoretical amino acid sequence and had an advanced structure resembling bovine collagen. Furthermore, rhCol III could facilitate basal biological behaviors of human skin fibroblasts, such as adhesion, proliferation and migration. rhCol III was beneficial for some extracellular matrix-expressing cell phenotypes. The study would shed light on the mechanism research of rhCol and cell interactions and further understanding of effectiveness in tissue regeneration.

Graphical abstract

胶原蛋白作为一种生物活性材料在再生医学领域产生了巨大的影响。几十年来，胶原蛋白不仅被用作支架材料，而且还被用作调节细胞生物学行为和表型的活性成分。然而，作为主要来源的动物源性胶原存在免疫原性、病毒感染风险以及生物活性序列与功能之间关系不明确等问题。重组人源胶原蛋白(rhCol)为再生医学提供了风险可控的替代方案。然而，rhCol的特性和rhCol与细胞的相互作用还需要进一步的研究，包括细胞行为和表型。本研究初步证实重组人源化III型胶原(rhCol III)符合理论氨基酸序列，具有类似牛胶原的高级结构。rhCol III能够促进人皮肤成纤维细胞的粘附、增殖和迁移等基本生物学行为。rhCol III对一些表达细胞外基质的细胞表型有益。本研究为rhCol与细胞相互作用的机制研究和进一步了解rhCol在组织再生中的作用提供了新的思路。图形抽象

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引用次数: 4

Advanced application of collagen-based biomaterials in tissue repair and restoration 胶原基生物材料在组织修复和修复中的先进应用

Journal of Leather Science and Engineering

Pub Date : 2022-11-07 DOI: 10.1186/s42825-022-00102-6

Jiayi Zhu, Zhulian Li, Yaping Zou, Gonggong Lu, Alfredo Ronca, Ugo D’Amora, Jie Liang, Yujiang Fan, Xingdong Zhang, Yong Sun

In tissue engineering, bioactive materials play an important role, providing structural support, cell regulation and establishing a suitable microenvironment to promote tissue regeneration. As the main component of extracellular matrix, collagen is an important natural bioactive material and it has been widely used in scientific research and clinical applications. Collagen is available from a wide range of animal origin, it can be produced by synthesis or through recombinant protein production systems. The use of pure collagen has inherent disadvantages in terms of physico-chemical properties. For this reason, a processed collagen in different ways can better match the specific requirements as biomaterial for tissue repair. Here, collagen may be used in bone/cartilage regeneration, skin regeneration, cardiovascular repair and other fields, by following different processing methods, including cross-linked collagen, complex, structured collagen, mineralized collagen, carrier and other forms, promoting the development of tissue engineering. This review summarizes a wide range of applications of collagen-based biomaterials and their recent progress in several tissue regeneration fields. Furthermore, the application prospect of bioactive materials based on collagen was outlooked, aiming at inspiring more new progress and advancements in tissue engineering research.

Graphical Abstract

在组织工程中，生物活性材料发挥着重要的作用，提供结构支持、细胞调控和建立适宜的微环境来促进组织再生。胶原蛋白作为细胞外基质的主要成分，是一种重要的天然生物活性物质，在科学研究和临床应用中有着广泛的应用。胶原蛋白可从多种动物来源获得，它可以通过合成或重组蛋白生产系统生产。就物理化学性质而言，使用纯胶原蛋白具有固有的缺点。因此，以不同方式加工的胶原蛋白可以更好地满足组织修复生物材料的特定要求。在这里，胶原可用于骨/软骨再生、皮肤再生、心血管修复等领域，通过不同的加工方法，包括交联胶原、复合、结构化胶原、矿化胶原、载体等形式，促进组织工程的发展。本文综述了胶原基生物材料的广泛应用及其在组织再生领域的最新进展。展望了以胶原蛋白为基础的生物活性材料的应用前景，以期激发组织工程研究的新进展和新进展。图形抽象

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引用次数: 18

Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical, anticoagulation and anti-calcification properties 多酚基杂化纳米聚集体修饰生物瓣膜小叶的胶原纤维，实现增强的机械、抗凝血和抗钙化性能

Journal of Leather Science and Engineering

Pub Date : 2022-10-23 DOI: 10.1186/s42825-022-00105-3

Shufen Li, Shiying Lang, Zhiqian Chen, Jingruo Chen, Weihua Zhuang, Yangrui Du, Yawen Yao, Gongyan Liu, Mao Chen

Glutaraldehyde (Glut)-crosslinked porcine pericardium and bovine pericardium are mainly consisted of collagen and widely used for the preparation of heterogenous bioprosthetic heart valves (BHV), which play an important role in the replacement therapy of severe valvular heart disease, while their durability is limited by degeneration due to calcification, thrombus, endothelialization difficulty and prosthetic valve endocarditis. Herein, we develop a novel BHV, namely, TPly-BP, based on natural tannic acid and polylysine to improve the durability of Glut crosslinked bovine pericardium (Glut-BP). Impressively, tannic acid and polylysine could form nanoaggregates via multiple hydrogen bonds and covalent bonds, and the introduction of nanoaggregates not only improved the mechanical properties and collagen stability but also endowed TPly-BP with good biocompatibility and hemocompatibility. Compared to Glut-BP, TPly-BP showed significantly reduced cytotoxicity, improved endothelial cell adhesion, a low hemolysis ratio and obviously reduced platelet adhesion. Importantly, TPly-BP exhibited great antibacterial and in vivo anti-calcification ability, which was expected to improve the in vivo durability of BHVs. These results suggested that TPly-BP would be a potential candidate for BHV.

Graphical abstract

戊二醛(Glut)交联的猪心包和牛心包主要由胶原蛋白组成，广泛用于制备异质生物人工心脏瓣膜(BHV)，在严重瓣膜性心脏病的替代治疗中发挥重要作用，但由于钙化、血栓、内皮化困难和人工瓣膜心内膜炎等原因导致的退变，限制了其耐久性。为了提高Glut交联牛心包(Glut- bp)的耐久性，我们开发了一种基于天然单宁酸和聚赖氨酸的新型BHV，即TPly-BP。单宁酸和聚赖氨酸可以通过多个氢键和共价键形成纳米聚集体，纳米聚集体的引入不仅提高了tpoly - bp的力学性能和胶原稳定性，而且赋予了tpoly - bp良好的生物相容性和血液相容性。与Glut-BP相比，TPly-BP显著降低细胞毒性，改善内皮细胞粘附，降低溶血率，明显降低血小板粘附。重要的是，TPly-BP具有良好的抗菌和体内抗钙化能力，有望提高bhv的体内持久性。这些结果表明，TPly-BP可能是BHV的潜在候选者。图形抽象

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引用次数: 1

Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical, anticoagulation and anti-calcification properties 多酚基杂化纳米聚集体修饰生物瓣膜小叶的胶原纤维，实现增强的机械、抗凝血和抗钙化性能

Journal of Leather Science and Engineering

Pub Date : 2022-10-23 DOI: 10.1186/s42825-022-00105-3

Shufen Li, Shiying Lang, Zhiqian Chen, Jing-Heng Chen, Weihua Zhuang, Yangrui Du, Yawen Yao, Gongyan Liu, Mao Chen

引用次数: 1

Optimization and application of UVC irradiation for prevention of fungal biodeterioration of vegetable tanned and chrome tanned leather 紫外线照射防止植物鞣革和铬鞣革真菌生物变质的优化及应用

Journal of Leather Science and Engineering

Pub Date : 2022-10-21 DOI: 10.1186/s42825-022-00104-4

Eshita Jhahan, Subarna Bhattacharyya, Anirban Chaudhuri, Nirmal Sarkar, Shaheen Akhtar, Punarbasu Chaudhuri

UV-C irradiation critically effects the growth of micro-fungi and also deteriorate leather materials. In the present study vegetable tanned and chrome tanned leather were infected with pure cultures of Aspergillus niger and Aspergillus flavus, which were isolated from stored leather materials. UV-C light (λ = 254 nm) was applied on infected leather for 15 and 60 min. The changes in leather qualities were examined through weight, tensile strength, scanning electron microscope, energy dispersive X-ray and Fourier transform infrared spectroscopy study after 15 and 30 days of fungal inoculation. Vegetable tanned leather was more vulnerable in case of fungal attack than chrome tanned leather while A. flavus showed more influence on leather deterioration than A. niger. The results showed that weight loss after 30 days for 15 and 60 min irradiation exposure was 1.3% compared to A. flavus infected leather (3.93%). The tensile strength of vegetable and chrome tanned UV irradiated leather was increased by 44% and 7% respectively. The scanning electron microscopic images exhibit the limited presence of conidiophores in UV-C exposed leather which confirmed the potentiality of irradiation for controlling fungal growth. The infrared spectral analysis of UV-C exposed infected leather samples showed neither shifting of wavenumber nor displacement of any functional groups. Altogether the efficacy of UV-C irradiation against biodeterioration of leather was concluded to be effective. This method can be used to control fungal growth without compromising the leather quality.

Graphical Abstract

UV-C辐照严重影响微真菌的生长，也会使皮革材料变质。本研究用从贮存皮革材料中分离的黑曲霉和黄曲霉纯培养物对植物鞣革和铬鞣革进行了感染。紫外- c光(λ = 254 nm)照射染病皮革15和60 min，接种真菌15和30 d后，通过重量、抗拉强度、扫描电镜、能量色散x射线和傅里叶变换红外光谱研究皮革质量的变化。植物鞣皮比铬鞣皮更容易受到真菌的侵袭，而黄曲霉对皮革变质的影响大于黑曲霉。结果表明，辐照15和60 min后30 d的革重损失为1.3%，而黄曲霉感染革重损失为3.93%。植物鞣和铬鞣紫外辐照皮革的抗拉强度分别提高44%和7%。扫描电镜图像显示，在UV-C暴露的皮革中存在有限的分生孢子，这证实了辐射控制真菌生长的潜力。对暴露于UV-C下的感染皮革样品进行红外光谱分析，未发现波数移位和官能团移位。综上所述，UV-C照射对皮革生物变质的效果是有效的。这种方法可以在不影响皮革质量的情况下控制真菌的生长。图形抽象

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引用次数: 1

Organosilicon leather coating technology based on carbon peak strategy 基于碳峰策略的有机硅皮革涂层技术

Journal of Leather Science and Engineering

Pub Date : 2022-10-19 DOI: 10.1186/s42825-022-00101-7

Wenkai Wang, Haojun Fan, Lijiang Song, Zhenya Wang, Heng Li, Jun Xiang, Qiang Huang, Xiangquan Chen

Based on the demand of carbon peak and carbon emission reduction strategy, divinyl-terminated polydimethylsiloxane (^ViPDMS^Vi), poly(methylhydrosiloxane) (PMHS), divinyl-terminated polymethylvinylsiloxane (^ViPMVS^Vi), and fumed silica were used as primary raw materials, polydimethylsiloxane (PDMS) synthetic leather coating was in situ constructed by thermally induced hydrosilylation polymerization on the synthetic leather substrate. The effect of the viscosity of ^ViPDMS^Vi, the active hydrogen content of PMHS, the molar ratio of vinyl groups to active hydrogen, the dosage of ^ViPMVS^Vi and fumed silica on the performance of PDMS polymer coating, including mechanical properties, cold resistance, flexural resistance, abrasion resistance, hydrophobic and anti-fouling properties were investigated. The results show that ^ViPDMS^Vi with high vinyl content and PMHS with low active hydrogen content is more conducive to obtaining organosilicon coating with better mechanical properties, the optimized dosage of ^ViPMVS^Vi and fumed silica was 7 wt% and 40 wt%, respectively. In this case, the tensile strength and the broken elongation of the PDMS polymer coating reached 5.96 MPa and 481%, showing reasonable mechanical properties for leather coating. Compared with polyurethane based or polyvinyl chloride based synthetic leather, the silicon based synthetic leather prepared by this method exhibits excellent cold resistance, abrasion resistance, super hydrophobicity, and anti-fouling characteristics.

Graphical Abstract

基于碳峰需求和碳减排策略，以端二乙烯基聚二甲基硅氧烷(ViPDMSVi)、聚甲基氢硅氧烷(PMHS)、端二乙烯基聚甲基乙烯硅氧烷(ViPMVSVi)和气相二氧化硅为主要原料，通过热诱导硅氢化聚合在合成革基体上原位构建聚二甲基硅氧烷(PDMS)合成革涂层。考察了ViPDMSVi的粘度、PMHS的活性氢含量、乙烯基与活性氢的摩尔比、vipmdmsvi和气相二氧化硅的用量对PDMS聚合物涂层的力学性能、耐寒性、抗弯性、耐磨性、疏水性和防污性能的影响。结果表明，高乙烯基含量的ViPDMSVi和低活性氢含量的PMHS更有利于获得力学性能较好的有机硅涂层，vipmdmsvi和气相二氧化硅的最佳用量分别为7 wt%和40 wt%。在此情况下，PDMS聚合物涂层的抗拉强度和断裂伸长率分别达到5.96 MPa和481%，具有较好的皮革涂层力学性能。与聚氨酯基或聚氯乙烯基合成革相比，该方法制备的硅基合成革具有优异的耐寒性、耐磨性、超疏水性和防污性。图形抽象

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引用次数: 2

The improvement of dispersity, thermal stability and mechanical properties of collagen fibers by silane modification: an exploration for developing new leather making technology 硅烷改性提高胶原纤维的分散性、热稳定性和力学性能:开发皮革新工艺的探索

Journal of Leather Science and Engineering

Pub Date : 2022-09-14 DOI: 10.1186/s42825-022-00100-8

Shuangfeng Xu, Hanzhong Xiao, Bi Shi

The effect of hydrophobic modification on the performances of collagen fibers (CFs) was investigated by using silane coupling agents with different alkyl chains as hydrophobic modifiers. It was found silane could be easily grafted onto CF surface through covalent bonds under 5% water content. This modification led to the transformation of surface wettability of CF from hydrophilic to hydrophobic. Interestingly, the change of surface wettability resulted in substantial improvement of the modified CF properties, presenting well dispersity of collagen fibers, higher thermal stability and enhanced mechanical properties in comparison with natural CF. The degree of improvement mainly depended on the length of alkyl chain in silane. Longer alkyl chain produced strong hydrophobicity and subsequently more superior performances of the modified CF. When the length of alkyl chain increased to 18 carbon atoms, the modified CF possessed durable superhydrophobicity even exposed to aqueous solutions of different pH, UV, and organic solvents, and had excellent thermal and mechanical properties like leather fibers. In general, this work clearly revealed that the properties of CF are closely and positively related to the hydrophobicity, which is suggestive in developing new leather making technology.

Graphical Abstract

以不同烷基链的硅烷偶联剂为疏水改性剂，研究了疏水改性对胶原纤维性能的影响。结果表明，在水含量为5%的条件下，硅烷可以很容易地通过共价键接枝到CF表面。这种改性导致CF的表面润湿性由亲水性转变为疏水性。有趣的是，表面润湿性的改变使得改性CF的性能有了很大的改善，与天然CF相比，胶原纤维的分散性好，热稳定性更高，力学性能也有所增强。改善的程度主要取决于硅烷中烷基链的长度。烷基链越长，改性后的CF疏水性越强，性能越优越。当烷基链长度增加到18个碳原子时，改性后的CF即使暴露在不同pH、UV和有机溶剂的水溶液中也具有持久的超疏水性，并具有优异的热性能和机械性能，如皮革纤维。总的来说，这项工作清楚地揭示了CF的性能与疏水性密切相关，这对开发新的皮革制造技术具有指导意义。图形抽象

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引用次数: 7

A review on room-temperature self-healing polyurethane: synthesis, self-healing mechanism and application 室温自愈聚氨酯的研究进展:合成、自愈机理及应用

Journal of Leather Science and Engineering

Pub Date : 2022-08-30 DOI: 10.1186/s42825-022-00097-0

Yupeng Li, Yong Jin, Wuhou Fan, Rong Zhou

Polyurethanes have been widely used in many fields due to their remarkable features such as excellent mechanical strength, good abrasion resistance, toughness, low temperature flexibility, etc. In recent years, room-temperature self-healing polyurethanes have been attracting broad and growing interest because under mild conditions, room-temperature self-healing polyurethanes can repair damages, thereby extending their lifetimes and reducing maintenance costs. In this paper, the recent advances of room-temperature self-healing polyurethanes based on dynamic covalent bonds, noncovalent bonds and combined dual or triple dynamic bonds are reviewed, focusing on their synthesis methods and self-healing mechanisms, and their mechanical properties, healing efficiency and healing time are also described in detial. In addition, the latest applications of room-temperature self-healing polyurethanes in the fields of leather coatings, photoluminescence materials, flexible electronics and biomaterials are summarized. Finally, the current challenges and future development directions of the room-temprature self-healing polyurethanes are highlighted. Overall, this review is expected to provide a valuable reference for the prosperous development of room-temperature self-healing polyurethanes.

Graphical abstract

聚氨酯具有优异的机械强度、良好的耐磨性、韧性、低温柔韧性等特点，在许多领域得到了广泛的应用。近年来，室温自愈聚氨酯引起了广泛和日益增长的兴趣，因为在温和的条件下，室温自愈聚氨酯可以修复损伤，从而延长其使用寿命并降低维护成本。本文综述了基于动态共价键、非共价键和复合双键或三重动态键的室温自修复聚氨酯的最新研究进展，重点介绍了它们的合成方法和自修复机理，并详细介绍了它们的力学性能、愈合效率和愈合时间。综述了室温自愈聚氨酯在皮革涂料、光致发光材料、柔性电子和生物材料等领域的最新应用。最后，重点介绍了室温自愈聚氨酯目前面临的挑战和未来的发展方向。综上所述，可望为室温自愈聚氨酯的繁荣发展提供有价值的参考。图形抽象

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引用次数: 6

Essential role of isoelectric point of skin/leather in leather processing 皮革等电点在皮革加工中的重要作用

Journal of Leather Science and Engineering

Pub Date : 2022-08-25 DOI: 10.1186/s42825-022-00099-y

Ya-nan Wang, Longyu Hu

引用次数: 7