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2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)最新文献

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Study of micromanipulation systemfor observing and positioning pathological slides 病理切片观察定位显微操作系统的研究
Junhui Zhu, Yong Wang, Fujun Sun, Changhai Ru, Ruihua Chen
Pathological observation is necessary for pathological diagnosis. In hospitals, the observation is done under the microscope to find the lesions on a pathological slide. Manual operating suffers from time consuming, unable to preserve and poor repeatability. In order to raise efficiency of pathological observation and be able to locate to the selected areas of slides for more specific investigations, an image expert system is study in this paper. The system is capable of image scanning, image mosaicking, and repeated positioning. A custom-adapted hardware platform is used for pathological slide scanning and image capturing. The scanning error caused by platform and camera is dealt with coordinate compensation. The images are mosaicked as a panorama by image registration and fusion. To realize the repeated positioning, the screen coordinate system and physical coordinate system are proposed. As the experimental results show, the system is able to acquire and store all the pathological images of a slide (20mm × 20mm) within 3 minutes and mosaic them as a panorama for observing and positioning. After repeated positioning, the positioning of those selected areas shown in the middle zone of the camera screen, covered the range of (420pix × 420pix). The success rate of repeated positioning is about 96%. The error is acceptable in pathological slide observation.
病理观察是病理诊断的必要条件。在医院,观察是在显微镜下进行的,以在病理切片上找到病变。人工操作耗时长,无法保存,重复性差。为了提高病理观察的效率,能够定位到切片的选定区域进行更具体的检查,本文研究了一种图像专家系统。该系统具有图像扫描、图像拼接、重复定位等功能。采用自定义的硬件平台进行病理切片扫描和图像采集。采用坐标补偿的方法处理由平台和摄像机引起的扫描误差。通过图像配准和融合,将图像拼接成全景图像。为了实现重复定位,提出了屏幕坐标系和物理坐标系。实验结果表明,该系统能够在3分钟内获取并存储一张20mm × 20mm的切片的所有病理图像,并将其拼接成全景图,用于观察和定位。经过反复定位,所选区域的定位显示在摄像头屏幕的中间区域,覆盖范围为(420pix × 420pix)。重复定位成功率约96%。病理切片观察误差是可以接受的。
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引用次数: 0
Detection of gold nanoparticles based on solid-state nanopore 基于固态纳米孔的金纳米颗粒检测
Feng He, Bohua Yin, Wanyi Xie, Leyong Yu, Shoufeng Tong, Liyuan Liang, Deqiang Wang
Gold nanoparticles hold unique optical and electronic properties and have been extensively applied as optical and electrochemical labels for DNA and protein detection. The nanopore based analysis of gold nanoparticles will provide us good insight for further study the conjugation of nanoparticles and DNA. In the present work, we demonstrated gold nanoparticles translocation through silicon nitride (SiN) nanopore via investigation of distribution of current blockage and dwell time of gold nanoparticles with different sizes, 10 nm and 15 nm respectively. 100 mM KCl solution with 0.075% Triton X-100 and 5 mM Tris was used to avoid the aggregation of negatively charged gold nanoparticles caused by van der Waals force. Nanopore based on SiN membrane was fabricated by current dielectric breakdown technology, and the diameter of the nanopore was calculated from an empirical equation, which is 18 nm. Experimental data was analyzed via Clampfit, version 10.6.0.13, and Origin 8 (OriginLab).
金纳米颗粒具有独特的光学和电子特性,已广泛应用于DNA和蛋白质检测的光学和电化学标记。基于纳米孔的金纳米颗粒的分析将为进一步研究纳米颗粒与DNA的结合提供良好的见解。本文通过研究10 nm和15 nm两种不同尺寸的金纳米颗粒的电流阻塞分布和停留时间,证明了金纳米颗粒在氮化硅纳米孔中的迁移。在100mm KCl溶液中加入0.075% Triton X-100和5mm Tris,以避免范德华力导致带负电荷的金纳米粒子聚集。采用电流介质击穿技术制备了基于SiN膜的纳米孔,并根据经验公式计算出纳米孔直径为18 nm。实验数据通过Clampfit 10.6.0.13版本和Origin 8 (OriginLab)进行分析。
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引用次数: 1
Tunable graphene-based infrared perfect absorber for sensing 可调谐石墨烯基红外传感完美吸收器
Peng Sun, F. Xia, Lili Liu, Lipeng Jiao, Kai Chen, M. Li, Qiyong Liu, Maojin Yun
In this paper, we proposed a perfect absorber composed of a periodic double-layer graphene ribbon arrays placed on a metallic reflector separated by a dielectric layer for infrared sensing. The anti-symmetric dipole-dipole coupling mode is excited as the impedance matchingCnar-rowband absorption spectrum. Numerical simulations show that the absorption and reflection properties of the absorber are sensitive to the refractive index of the surrounding medium. Furthermore, the plasmon resonance wavelength can be tuned by varying the Fermi energy level of graphene. Such a plas-monic absorber with high sensitivity can be beneficial for chemical and biosensor applications.
在本文中,我们提出了一种完美的吸收器,该吸收器由放置在由介电层隔开的金属反射器上的周期性双层石墨烯带状阵列组成,用于红外传感。将反对称偶极子-偶极子耦合模式激发为与cnar波段吸收谱相匹配的阻抗。数值模拟表明,吸收器的吸收和反射特性对周围介质的折射率很敏感。此外,等离子体共振波长可以通过改变石墨烯的费米能级来调节。这种具有高灵敏度的等离子体吸收剂可用于化学和生物传感器的应用。
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引用次数: 6
An implementation of SLAM using ROS and Arduino 基于ROS和Arduino的SLAM实现
A. Ibanez, Renxi Qiu, Dayou Li
This paper aims to explore the Simultaneous Localization and Mapping (SLAM) problem in the context of implementation using the Robot Operating System (ROS) framework and the Arduino technology. The implementation of an inexpensive differential drive robot for SLAM is detailed and verified by mapping experiments conducted within domestic environments. Furthermore, a modest, yet convenient, theoretical explanation of the algorithm (Rao-Blackwellization particle filter) behind the platform is also presented. Overall, this report leads to a simple and cost effective way — including a code base and guidelines — to create robots for 2D mapping using modern technologies such as ROS.
本文旨在探讨在机器人操作系统(ROS)框架和Arduino技术实现背景下的同步定位和地图绘制(SLAM)问题。通过在国内环境中进行的测绘实验,详细介绍了一种用于SLAM的廉价差动驱动机器人的实现和验证。此外,对平台背后的算法(rao - blackwell化粒子滤波)也给出了一个适度但方便的理论解释。总体而言,本报告提供了一种简单且经济有效的方法,包括代码库和指南,可以使用ROS等现代技术创建用于2D绘图的机器人。
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引用次数: 9
Stretching of DNA molecules on mica surfaces by magnetic field 磁场对云母表面DNA分子的拉伸
Feifei Wang, Ying Wang, Tingting Huang, Fenfen Guo, Jinyun Liu, Zhengxun Song, Z. Weng, Zuobin Wang
This paper presents a method for the stretching of DNA molecules on mica surfaces by magnetic field. In the experiment, the magnetic fields with different intensities were generated using a cylindrical coil and were used to study their effects on DNA molecules. The magnetic field intensity was controlled by the electric current flowing through the coil. The imaging of DNA molecules was performed by atomic force microscope (AFM) in the same position on the mica surface after the treatment with the magnetic field. It was found that the DNA molecules were gradually straightened with the increase of magnetic field intensity, and the straightening performance was better than that of the molecular combing method in the experiment. In addition, the degree of DNA straightening was related to the speed at which DNA molecules were dropped to the mica surface, the amount of DNA charges and the direction of magnetic field.
本文提出了一种利用磁场对云母表面DNA分子进行拉伸的方法。在实验中,使用圆柱形线圈产生不同强度的磁场,并用于研究它们对DNA分子的影响。磁场强度由流经线圈的电流来控制。利用原子力显微镜(AFM)对经磁场处理后的云母表面相同位置的DNA分子进行成像。结果发现,随着磁场强度的增加,DNA分子逐渐被拉直,且实验中的拉直性能优于分子梳理方法。此外,DNA的矫直程度与DNA分子落向云母表面的速度、DNA的电荷量和磁场方向有关。
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引用次数: 1
Intentionally encapsulated metal alloys within vertically aligned multi-walled carbon nanotube array via chemical vapor deposition technique 利用化学气相沉积技术将金属合金封装在垂直排列的多壁碳纳米管阵列中
H. Inoue, Takuma Hayashi, T. Nishikawa, Y. Hayashi, M. Hada, T. Tokunaga, G. Amaratunga
This paper presents a growth and characterization of vertically aligned PdxCoi-x alloy encapsulated inside Multi-Walled Carbon Nanotube (MWCNT) arrays on Pd/Co thin layers coated on Si substrate by a dc bias-enhanced plasma chemical vapor deposition (CVD) method. The Metal Alloy Encapsulated within MWCNTs (MAE-MWCNTs) were characterized by a scanning electron microscope (SEM) and a transmission electron microscopy (TEM). The SEM images show the teardrop-shape particles encapsulated within the tube top of MWCNTs. A vibrating sample magnetometer was used to study the magnetism of a large number of MAE-MWCNTs on Si substrate at room temperature. The hysteresis loop of the ME-MWCNTs shows clear ferromagnetic behavior and the easy axis of magnetization is parallel to the MEA-MWCNT tube axis, as can be elucidated from the large coercive fields and remanence values. Moreover, TEM off-axis electron holograms were used to study the magnetism of the individual MAE-MWCNT or the two pair of MAE-MWCNTs. Based on electron holography, we have successfully obtained the saturation magnetization of 0.7 T and 1.12 T for the individual MAE-MWCNT with diameters of 41 nm and 83 nm, respectively.
本文采用直流偏置增强等离子体化学气相沉积(CVD)方法,在Si衬底上涂覆Pd/Co薄层的多壁碳纳米管(MWCNT)阵列中生长和表征了垂直排列的PdxCoi-x合金。采用扫描电镜(SEM)和透射电镜(TEM)对包封在MWCNTs内的金属合金(MAE-MWCNTs)进行了表征。SEM图像显示泪滴状颗粒包裹在MWCNTs的管顶。采用振动样品磁强计研究了Si衬底上大量MAE-MWCNTs在室温下的磁性。me - mwcnt的磁滞回线表现出明显的铁磁行为,易磁化轴平行于MEA-MWCNT管轴,这可以从大的矫顽力场和剩磁值中得到解释。此外,利用TEM离轴电子全息图研究了单个MAE-MWCNT或两对MAE-MWCNT的磁性。基于电子全息技术,我们成功地获得了直径为41 nm和83 nm的MAE-MWCNT的饱和磁化强度分别为0.7 T和1.12 T。
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引用次数: 0
Fabrication and evaluation of aluminum nano-wire grid polarizer array in two different structure types 两种不同结构类型铝纳米线栅极器阵列的制备与评价
Shuyi Li, M. Yu, Zhengxun Song, Zuobin Wang, Yinxue Fan, Bingyu Zhao
Aluminum nano-wire grid structure based on stokes vector plays an important role in the polarization application technology. In this paper, we present the methods of fabricating aluminum nano-wire grid in a single direction structure and a four-orientation structure using EBL (electron beam lithography) and ICP-RIE (inductively coupled plasma-reactive ion etching). According to the request of visible light polarization, the grating's period was designed to 200nm. Based on the experimental measurement and simulation analysis, the extinction ratio of single direction nano-wire grid structure is higher than multi-orientation nano-wire grid structure in preparation of parameters under the same conditions. Two aspects were optimized to improve the performance of latter grating array structure.
基于斯托克斯矢量的铝纳米线网格结构在极化应用技术中起着重要的作用。本文介绍了利用电子束光刻技术和电感耦合等离子体反应离子刻蚀技术制备单向结构和四向结构铝纳米线网格的方法。根据可见光偏振的要求,将光栅的周期设计为200nm。基于实验测量和仿真分析,在相同条件下制备参数时,单向纳米线网格结构的消光比高于多向纳米线网格结构。从两个方面对后一种光栅阵列结构的性能进行了优化。
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引用次数: 1
Microstructural characteristics and nanomechanical properties of hindwings of the Asian ladybeetle, harmonia axyridis 亚洲瓢虫后翅的微观结构特征和纳米力学性能
Jiyu Sun, Chao Liu, Wei Wu, Ruijuan Du, Zhijun Zhang
The hindwings are thin and fragile. However, they can display countless folding/unfolding actions during their lifetime. At the root of the Asian ladybeetle (Harmonia axyridis) hindwings, three thicker veins spread out. In this study, laser scanning confocal microscope (LSCM) was used to acquire the cross-section microstructures of the three thinker main veins. And it was found that the thickness of dorsal side (DS) and ventral side (VS) are different. The irregularly shaped vein chambers are observed from the cross-section microstructure of the three veins. Then the reduced modulus (Er) and hardness (H) of DS and VS were investigated along the veins varying from wing base to the region of principal transverse fold by nanoindentation. All the Er and H appear a tendency of linear increasing. In the folding region, the Er and H of DS were larger than that of VS. The results will be useful to the design of new deployable MAV and bioinspired systems.
后翅又薄又脆弱。然而,它们一生中可以展示无数的折叠/展开动作。在亚洲瓢虫(Harmonia axyridis)后翅的根部,有三条较粗的静脉展开。本研究采用激光扫描共聚焦显微镜(LSCM)获得了三条思考者主静脉的横截面显微结构。发现背侧(DS)和腹侧(VS)的厚度不同。从三个矿脉的断面显微结构可以观察到不规则形状的脉室。然后利用纳米压痕法研究了从翼基到主横向褶皱区域沿不同纹路DS和VS的降低模量Er和硬度H。所有的Er和H都呈现线性增加的趋势。在折叠区,DS的Er和H均大于vs,研究结果将为新型可展开MAV和仿生系统的设计提供参考。
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引用次数: 3
Surface properties of graphene platelets/nickel composite coatings 石墨烯薄片/镍复合涂层的表面性能
M. Li, Xiaoping Zhang, Yaqin Tian, Jie Ren, Jian Liu, Sai Priya Munagala, K. Jiang
Nickel has been widely used as a strong and highly wear resistant material in super alloys, electronics, gas turbines, and automotive industry to name a few. Further improvements on some properties, such as wear and corrosion resistances, of nickel alloys and composites have been performed. The appearance of graphene provides a new possibility to further the exploration of a new nickel composite to suit particular applications. In this paper, research on electrodeposition of graphene platelets (GPLs) and laminates is reported in an effort to study the potential of the nickel composites in electrical conductivity and hardness for applications. The presented research focusses on the electrodeposition of GPL in Ni matrix and characterisation of the composite properties. SEM analysis showed homogenous dispersion of the GPL over the Ni Surface. Characterisation was also carried out by hardness measurements and conductivity test. The results are compared with each other and with pure Ni samples. The comparison shows an increased hardness and conductivity of the surface with the increase in number of graphene layers. This work opens a new window of applications and provides a way to improvise Ni components for better.
镍作为一种强而耐磨的材料被广泛应用于超级合金、电子、燃气轮机和汽车工业等领域。镍合金和复合材料的某些性能,如耐磨性和耐腐蚀性得到了进一步的改进。石墨烯的出现为进一步探索适合特定应用的新型镍复合材料提供了新的可能性。本文报道了电沉积石墨烯薄片(GPLs)和层压板的研究,以研究镍复合材料在电导率和硬度方面的应用潜力。本文主要研究了GPL在Ni基体上的电沉积及其复合材料性能的表征。SEM分析表明GPL在Ni表面呈均匀分散。还通过硬度测量和电导率测试进行了表征。结果与纯Ni样品进行了比较。比较表明,随着石墨烯层数的增加,表面的硬度和导电性增加。这项工作打开了一个新的应用窗口,并提供了一种更好地即兴制作Ni组件的方法。
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引用次数: 1
Development and analysis of a tip-separated flexure needle based on piezo actuation 基于压电驱动的针尖分离柔性针的研制与分析
Bo Zhang, Fangxin Chen, Haiyang Li, Z. Du, W. Dong
The bevel-tip flexure needle will naturally bend during insertion in soft tissue due to the tip asymmetry. Therefore the needle enables robotically steering by rotating the needle tip resulting from the needle base rotating. However a significant orientation discrepancy between the needle tip and the needle base caused by the friction torque between the needle shaft and the tissue results in inaccurately steering. To address this problem, a tip-separated flexure needle actuated by the shear piezoelectric actuator (SPA) based on the stick-slip theory is proposed in this paper. Compared to the conventional needles, the proposed one is directly driven at the tip end, which will significantly decrease the friction torque in the inserting procedure. Essentially, the separated tip is a rotary motor based on the piezo actuated. To verify the feasibility of the proposed design for the insertion application, the motion performances of the rotary motor such as the load capacity, step characters are analyzed by the established model in this paper. Furthermore, an experimental setup with an enlarged rotary motor is designed and fabricated. Finally, it is verified that the motion performance has no connection to the motor size, i.e., the tip can, in some extent, be downsized according to the actual requirement. The proposed piezo-actuated tip can also been employed in other micro scale application as a rotary actuator.
由于针尖不对称,斜尖弯曲针在插入软组织时自然弯曲。因此,该针通过旋转由针基旋转产生的针尖来实现机器人转向。然而,由于针轴和组织之间的摩擦扭矩,针尖和针基之间的方向差异很大,导致转向不准确。针对这一问题,本文提出了一种基于粘滑理论的剪切压电致动器(SPA)驱动的尖端分离柔性针。与传统的针相比,该针在针尖端直接驱动,这将大大减少插入过程中的摩擦力矩。本质上,分离的尖端是一个基于压电驱动的旋转电机。为了验证所提出的设计在插入应用中的可行性,本文利用所建立的模型对旋转电机的负载能力、阶跃特性等运动特性进行了分析。在此基础上,设计并制作了一个放大旋转电机的实验装置。最后验证了运动性能与电机尺寸无关,即针尖可以根据实际需要进行一定程度的缩小。所提出的压电驱动尖端也可以作为旋转驱动器用于其他微尺度应用。
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引用次数: 0
期刊
2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)
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