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2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)最新文献

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Double layer nanopore fabricated by FIB and TEM 用FIB和TEM制备双层纳米孔
Haojie Yang, Wei Si, Jingjie Sha, Yunfei Chen, Xiao Xie, Anping Ji
In order to support the third generation DNA sequencing technique, a double layers nanopore consisting of silicon nitride (Si3N4) and graphene is fabricated in this paper. Firstly, high yield Si3N4 nanofilm chips were manufactured successfully after SißNt deposition, etching and release process. Then, focused ion beam (FIB) was used to manufacture SißNi nanopore on Si3N4 nanofilm chips with optimized process. The graphene sheet was synthesized with chemical vapor deposition (CVD) method and transferred onto the Si3N4 membrane milling area. We use transmission electron microscope (TEM) to fabricate the nanopore in the graphene membrane above the center of the Si3N4 nanopore. The diameter of SißNt layer was characterized to be 28 nm and the diameter of graphene nanopore was 4 nm which is fabricated by FIB and electron beam respectively. This method provides a useful tool to nanopore-based DNA sequence.
为了支持第三代DNA测序技术,本文制备了由氮化硅(Si3N4)和石墨烯组成的双层纳米孔。首先,通过SißNt沉积、蚀刻和释放工艺,成功制备出高产量的Si3N4纳米膜芯片。然后,利用聚焦离子束(FIB)优化工艺,在Si3N4纳米膜芯片上制备SißNi纳米孔。采用化学气相沉积(CVD)法制备了石墨烯薄片,并将其转移到氮化硅制膜区。利用透射电子显微镜(TEM)在氮化硅纳米孔中心上方的石墨烯膜上制备了纳米孔。采用FIB法和电子束法制备的SißNt层直径为28 nm,石墨烯纳米孔直径为4 nm。该方法为基于纳米孔的DNA测序提供了一种有用的工具。
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引用次数: 1
Manipulation of magnetic nanoparticles by optically induced dielectrophoresis 光诱导介质电泳对磁性纳米颗粒的操纵
Ying Wang, Feifei Wang, Tingting Huang, Fenfen Guo, Ying Xie, Zhengxun Song, Jinyun Liu, Zuobin Wang, Yihui Wang
This paper presents a method for the manipulation of magnetic nanoparticles by optically induced dielectrophoresis (ODEP) device that can realize the transportation and convergence of nanoparticles. ODEP can be realized with a sandwich structure of three layers including the photoconductive layer, the liquid layer with the sample and the indium tin oxide electrode (ITO) layer. In this work, magnetic nanoparticles with the diameter of 10–100nm were successfully manipulated by positive dielectrophoresis force. The solution with magnetic nanoparticles on a mica substrate placed in the sandwich structure was dried in the air and imaged by atomic force microscope (AFM). The AFM images showed that the magnetic nanoparticles were converged in the illumination area. This method can be used to manipulate magnetic nanoparticles.
本文提出了一种利用光诱导介电泳(ODEP)装置对磁性纳米粒子进行操纵的方法,实现了纳米粒子的输运和会聚。ODEP可以通过三层夹层结构实现,包括光导层、样品液体层和氧化铟锡电极(ITO)层。在本研究中,我们成功地利用正电介质力对直径为10-100nm的磁性纳米颗粒进行了制备。将磁性纳米颗粒溶液置于夹层结构的云母衬底上,在空气中干燥,并通过原子力显微镜(AFM)成像。原子力显微镜(AFM)图像显示,磁性纳米颗粒在光照区聚集。该方法可用于操纵磁性纳米颗粒。
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引用次数: 0
Lithography-induced wettability changes of silicon 光刻诱导硅的润湿性变化
Jiajing Zhu, Chengjuan Yang, Fujun Wang, Yanling Tian, Xianping Liu
In recent years, the fabrication of hydrophobic surface has become a research hotspot. In this paper, three different patterns were fabricated successfully on the silicon wafers by lithography technology and the effects of dimension and interval parameters on surface wettability were the highlights in this study. Due to the different structural features, the overall average of linear pattern's contact angles were less than the overall average of grid pattern's contact angles and dot pattern's contact angles. What's more, the dimension parameters played a more important role than the interval parameters on the surface wettability. The smaller dimension of microstructure obviously preferred to have higher contact angle with better surface hydrophobic performance, especially when the size is less than 100μm. When the dimension of microstructure was 60μm, the contact angle were all larger than 90°, and some of them even reached the super-hydrophobic surface (larger than 150°).
近年来,疏水表面的制备已成为研究热点。本文采用光刻技术在硅片上成功制备了三种不同的图案,其中尺寸和间隔参数对表面润湿性的影响是本研究的重点。由于结构特征不同,线形图案接触角的总体平均值小于网格图案和点形图案接触角的总体平均值。尺寸参数比间距参数对表面润湿性的影响更大。微观结构尺寸越小,接触角越大,表面疏水性能越好,特别是当微观结构尺寸小于100μm时。当微观结构尺寸为60μm时,接触角均大于90°,有的甚至达到超疏水表面(大于150°)。
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引用次数: 4
A parallel kinematic scanner designed for high-speed atomic force microscopy 一种为高速原子力显微镜设计的平行运动扫描仪
Xianbin He, Liangyu Cui, K. Cai, Yanling Tian, Xianping Liu
Atomic force microscopy (AFM) is a useful tool in nanoscale measurement. However, conventional AFM suffers from slow scan speed, limiting the use for biological detection or nanofabrication, due to the limited bandwidth of AFM components. In which the resonant frequency of the AFM scanner is usually too low to achieve high-speed scanning. In this paper, a parallel kinematic piezoelectric actuator (PZT) AFM scanner is designed to achieve high-speed atomic force microscopy (HS-AFM) scanning. After that, finite element analysis (FEA) is adopted to characterize the scanner. Finally, images of standard gratings obtained at 25 Hz with our home-made AFM system is presented after calibration and motion coupling compensation.
原子力显微镜(AFM)是纳米尺度测量的一种有用工具。然而,由于AFM组件的带宽有限,传统AFM的扫描速度较慢,限制了其在生物检测或纳米制造中的应用。其中原子力显微镜扫描仪的谐振频率通常太低,无法实现高速扫描。为了实现原子力显微镜(HS-AFM)的高速扫描,设计了一种并联运动压电致动器(PZT) AFM扫描仪。然后,采用有限元分析(FEA)对扫描仪进行表征。最后给出了国产AFM系统经标定和运动耦合补偿后在25 Hz下得到的标准光栅图像。
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引用次数: 0
Design and modeling of a 2-DOF decoupled rotation platform for micro-manipulation 面向微操作的二自由度解耦旋转平台设计与建模
C. Liang, Fujun Wang, Yanling Tian, Dawei Zhang
In high precision micro-manipulation task, precision angle adjustment is very important, which directly affects the quality of micro-manipulation. In this paper a novel 2-DOF (degree of freedom) rotation platform driven by two piezoelectric (PZT) actuators is designed to realize precision angle adjustment. The rotation platform has compact flexure-based mechanical structure and light weight. The rotation decoupling in X-and Y-axes are realized through the Hook joint. In order to obtain large range rotational angle, bridge-type mechanism is utilized in the 2-DOF rotation platform. An analytical model for rotational angle and input stiffness calculation is established. The influences of key parameters on the rotational angle as well as input stiffness of the rotation platform are analyzed. Finite element analysis (FEA) is conducted to evaluate the analytical model. The results of FEA fit the analytical model well and show the rotation platform exhibits good performance.
在高精度的微操作任务中,角的精确调节是非常重要的,它直接影响微操作的质量。本文设计了一种由两个压电驱动器驱动的2自由度旋转平台,实现了高精度角度调节。旋转平台具有紧凑的挠性机械结构,重量轻。通过Hook关节实现x轴和y轴的旋转解耦。为了获得大范围的旋转角度,在二自由度旋转平台中采用了桥式机构。建立了转角和输入刚度计算的解析模型。分析了关键参数对旋转平台转角和输入刚度的影响。对分析模型进行了有限元分析(FEA)。有限元分析结果与解析模型吻合较好,表明旋转平台具有良好的性能。
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引用次数: 0
Fluidic simulation and analysis of spiral, U-shape and curvilinear nano channels for biomedical application 生物医学应用中螺旋、u形和曲线纳米通道的流体模拟与分析
M. Afzal, S. Tayyaba, Fazal-e-Aleem, M. Ashraf, M. Khalid Hossain, N. Afzulpurkar
This research work presents the simulation and analysis of blood flow in tortuous veins. Three different sized nano channels like spiral, u-shape and curvilinear have been simulated using ANSYS FLUENT. The radius of 200 nm has been considered for all channels during simulation. Flow rate and velocity of these channels have been determined. For spiral, U-shape and curvilinear channels, the flow rate and velocity of 236 pL/s and 18.73 cm/s, 245 pL/s and 19.45 cm/s and 248.8 pL/s and 19.75 cm/s have been observed respectively.
这项研究工作是对弯曲静脉血流的模拟和分析。利用ANSYS FLUENT软件对螺旋形、u形和曲线形三种不同尺寸的纳米通道进行了数值模拟。仿真中考虑了所有通道的半径为200nm。测定了这些通道的流量和流速。螺旋、u形和曲线通道的流速和速度分别为236 pL/s和18.73 cm/s, 245 pL/s和19.45 cm/s, 248.8 pL/s和19.75 cm/s。
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引用次数: 5
Orthogonal experiment on the preparation of hydrophobic Ti6Al4V surface by WEDM 电火花切割制备疏水Ti6Al4V表面的正交实验
Jinkai Xu, Xuefeng Li, Jingjing Liu, Huadong Yu
The surface roughness of the hydrophobic titanium alloy was obtained by using the electric spark wire cutting (Ti6Al4V) technology. The surface of the titanium alloy was measured and characterized by means of ultra depth of field microscopy, scanning electron microscopy and contact angle measurement. The pulse width, the number of power transistors (peak current) and feed speed parameters were optimized by orthogonal experiment, and the influence of these parameters on the wettability of Ti6Al4V surface was discussed. The results show that when the pulse width is 32μs, the number of the power tube is 4, the feed rate is 50 μm/s, the contact angle of Ti6Al4V is preferably 142 degrees.
采用电火花线切割(Ti6Al4V)技术获得疏水钛合金的表面粗糙度。采用超景深显微镜、扫描电镜和接触角测量等方法对钛合金表面进行了测量和表征。通过正交实验优化了脉冲宽度、功率晶体管数(峰值电流)和馈电速度等参数,并讨论了这些参数对Ti6Al4V表面润湿性的影响。结果表明:当脉冲宽度为32μs,功率管数为4根,进给速率为50 μm/s时,Ti6Al4V的接触角为142°。
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引用次数: 1
H∞ control for piezo-actuated nanopositioning stages with time delays 具有时滞的压电驱动纳米定位平台的H∞控制
Zhiming Zhang, P. Yan
Many piezo-driven nanopositioning systems employ ultra high resolution capacitive sensors for displacement feedback, which results in significant time delays induced by AD conversion. The infinite dimensionality of such systems poses new challenges for nanopositioning control, where traditional control methods can not be applied directly. In this paper, a model with time delay on a nanopositioning stage is discussed, and a parameter identification method is further deployed using experiments to determine the time delay and other model parameters. A robust H∞ control design approach is also developed by using Pade expansion to approximate the time delay block. Real time experiments with the proposed control design are conducted on a piezo-actuated nanopositioning stage, where high precision motions, robustness against model uncertainties, as well as hysteresis compensation capability, are demonstrated, which significantly outperforms traditional PI control approach.
许多压电驱动的纳米定位系统采用超高分辨率电容式传感器进行位移反馈,这导致了AD转换引起的明显的时间延迟。这类系统的无限维性给传统控制方法无法直接应用的纳米定位控制提出了新的挑战。本文讨论了纳米定位阶段的时滞模型,并通过实验进一步部署了一种参数识别方法来确定模型的时滞和其他参数。利用Pade展开逼近时滞块,提出了一种鲁棒的H∞控制设计方法。在一个压电驱动的纳米定位平台上进行了实时实验,实验结果表明,该控制设计具有高精度运动、对模型不确定性的鲁棒性以及滞回补偿能力,显著优于传统的PI控制方法。
{"title":"H∞ control for piezo-actuated nanopositioning stages with time delays","authors":"Zhiming Zhang, P. Yan","doi":"10.1109/3M-NANO.2017.8286292","DOIUrl":"https://doi.org/10.1109/3M-NANO.2017.8286292","url":null,"abstract":"Many piezo-driven nanopositioning systems employ ultra high resolution capacitive sensors for displacement feedback, which results in significant time delays induced by AD conversion. The infinite dimensionality of such systems poses new challenges for nanopositioning control, where traditional control methods can not be applied directly. In this paper, a model with time delay on a nanopositioning stage is discussed, and a parameter identification method is further deployed using experiments to determine the time delay and other model parameters. A robust H∞ control design approach is also developed by using Pade expansion to approximate the time delay block. Real time experiments with the proposed control design are conducted on a piezo-actuated nanopositioning stage, where high precision motions, robustness against model uncertainties, as well as hysteresis compensation capability, are demonstrated, which significantly outperforms traditional PI control approach.","PeriodicalId":6582,"journal":{"name":"2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)","volume":"84 1","pages":"224-228"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82065489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Controlled manipulation of TRAIL into single human colon cancer cells using atomic force microscope 利用原子力显微镜控制TRAIL进入单个人结肠癌细胞
Yingmin Qu, Jinyun Liu, Guoliang Wang, Zhengxun Song, Zuobin Wang
In this study, an AFM tip was used to penetrate the human colon cancer cells (SW480) in the culture medium containing pEGFP-N1-TRAIL plasmids. The trail plasmids encoded with the enhanced green fluorescent protein (EGFP) were moved into the SW480 cells through membrane holes created by the AFM probe. Following the penetration, the culture medium was changed into the RPMI1640 medium supplemented with 10% of fetal bovine serum and incubated for 24h. The expression of PEGFP-N1-TRAIL in SW480 cells was then observed by inverted fluorescence microscope. The experiment results indicate that the AFM tip can be used to penetrate the membranes of targeted cells individually.
本研究使用AFM尖端在含有pEGFP-N1-TRAIL质粒的培养基中穿透人结肠癌细胞(SW480)。用增强的绿色荧光蛋白(EGFP)编码的trail质粒通过AFM探针形成的膜孔进入SW480细胞。穿透后,将培养基改为添加10%胎牛血清的RPMI1640培养基,孵育24h。倒置荧光显微镜观察PEGFP-N1-TRAIL在SW480细胞中的表达。实验结果表明,AFM尖端可以单独穿透目标细胞的膜。
{"title":"Controlled manipulation of TRAIL into single human colon cancer cells using atomic force microscope","authors":"Yingmin Qu, Jinyun Liu, Guoliang Wang, Zhengxun Song, Zuobin Wang","doi":"10.1109/3M-NANO.2017.8286333","DOIUrl":"https://doi.org/10.1109/3M-NANO.2017.8286333","url":null,"abstract":"In this study, an AFM tip was used to penetrate the human colon cancer cells (SW480) in the culture medium containing pEGFP-N1-TRAIL plasmids. The trail plasmids encoded with the enhanced green fluorescent protein (EGFP) were moved into the SW480 cells through membrane holes created by the AFM probe. Following the penetration, the culture medium was changed into the RPMI1640 medium supplemented with 10% of fetal bovine serum and incubated for 24h. The expression of PEGFP-N1-TRAIL in SW480 cells was then observed by inverted fluorescence microscope. The experiment results indicate that the AFM tip can be used to penetrate the membranes of targeted cells individually.","PeriodicalId":6582,"journal":{"name":"2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)","volume":"24 1","pages":"345-348"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85672869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Construction of superhydrophobic surfaces by sol-gel techniques 溶胶-凝胶技术构建超疏水表面
Liang Gu, Yanyan Wang, Chengyun Xu, Feng Zhang, Zhuhui Wu, Xiaoxing Zhang, Zhenwu Shi, C. Peng
In this work, SÌO2 sol and 1H, 1H, 2H, 2H-perfluorodecylsilane are mixed in a certain proportion by ultrasonic to obtain modified SiO2 sol and gel. A superhydrophobic coating with a contact angle of 160° and a slide angle of less than 5° was constructed by spin coating on a glass substrate. The sol-gel techniques we used is simple and inexpensive, and the as-constructed superhydrophobic coatings are relatively uniform. In addition, by controlling the number of spin coating, the durability of the coating can be effectively enhanced. It is believed that this technique can hold a great potential in superhydrophobic surface fabrication.
本工作将SÌO2溶胶与1H、1H、2H、2H-全氟十二烷基硅烷按一定比例超声混合,得到改性SiO2溶胶和凝胶。在玻璃基板上采用自旋镀膜的方法制备了接触角为160°、滑动角小于5°的超疏水涂层。采用溶胶-凝胶技术制备的超疏水涂层结构简单,成本低廉,且制备的超疏水涂层相对均匀。另外,通过控制旋涂次数,可以有效地提高涂层的耐久性。认为该技术在超疏水表面制造中具有很大的潜力。
{"title":"Construction of superhydrophobic surfaces by sol-gel techniques","authors":"Liang Gu, Yanyan Wang, Chengyun Xu, Feng Zhang, Zhuhui Wu, Xiaoxing Zhang, Zhenwu Shi, C. Peng","doi":"10.1109/3M-NANO.2017.8286295","DOIUrl":"https://doi.org/10.1109/3M-NANO.2017.8286295","url":null,"abstract":"In this work, SÌO2 sol and 1H, 1H, 2H, 2H-perfluorodecylsilane are mixed in a certain proportion by ultrasonic to obtain modified SiO2 sol and gel. A superhydrophobic coating with a contact angle of 160° and a slide angle of less than 5° was constructed by spin coating on a glass substrate. The sol-gel techniques we used is simple and inexpensive, and the as-constructed superhydrophobic coatings are relatively uniform. In addition, by controlling the number of spin coating, the durability of the coating can be effectively enhanced. It is believed that this technique can hold a great potential in superhydrophobic surface fabrication.","PeriodicalId":6582,"journal":{"name":"2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)","volume":"18 1","pages":"156-160"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85645309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
期刊
2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)
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