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2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)最新文献

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A hyperelastic model for mechanical responses of adherent cells in microinjection 显微注射中贴壁细胞力学反应的超弹性模型
Tianyao Shen, B. Shirinzadeh, Y. Zhong, Julian Smith
Single cell microinjection is widely used in biological sciences, especially in genetic engineering and cytopathology. To investigate mechanical responses of the adherent cell in microinjection, a general geometrical description of adherent cells in microinjection is proposed. Based on finite strain theory in isotropic hyperelasticity and minimal potential energy principle, a hyperelastic model of the adherent cell is developed. Factors affecting the interaction force and the stress distribution in the adherent cell penetration are revealed and analyzed. The force-deformation relationship obtained in the proposed model shows high similarity with classical Hertz model, while more detailed mechanical behaviours of the adherent cell in microinjection can be discovered from the proposed model.
单细胞显微注射在生物科学,特别是基因工程和细胞病理学中有着广泛的应用。为了研究微注射中贴壁细胞的力学响应,提出了一种微注射中贴壁细胞的一般几何描述。基于各向同性超弹性的有限应变理论和最小势能原理,建立了贴壁单元的超弹性模型。揭示并分析了影响贴壁细胞穿透过程中相互作用力和应力分布的因素。该模型得到的力-变形关系与经典赫兹模型具有较高的相似性,同时该模型可以揭示微注射过程中贴壁细胞更详细的力学行为。
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引用次数: 3
Growth of single crystal WS2 thin films via atmospheric pressure CVD 常压CVD法生长WS2单晶薄膜
Biao Zhou, Chen-Yi Su, Biao Shi, Yunjiao Wang, Leyong Yu, Shuanglong Feng, Deqiang Wang
Single crystal WS2 film has been paid much more attentions due to its special optical-electrical performance and potential application in the field of biosensor and photodetector in recent years. In this work, we focused on the growth of single crystal WS2 and explored the effect of the position of sulfur and carrier gas flow rate on the nucleation density systematically. The results indicated that the nucleation density of WS2 varies obviously correspond to sulfur position and gas flow, the reasons of the variety on the nucleation density was investigated. Meanwhile, granular and massive WS2 was characterized by an optical microscope, atomic force microscope and Raman spectra.
单晶WS2薄膜由于其特殊的光电性能和在生物传感器、光电探测器等领域的潜在应用,近年来受到了广泛的关注。本文以WS2单晶的生长为研究对象,系统地探讨了硫的位置和载气流速对WS2单晶成核密度的影响。结果表明,WS2的成核密度随硫的位置和气体流量的变化有明显的变化,并探讨了成核密度变化的原因。同时,利用光学显微镜、原子力显微镜和拉曼光谱对颗粒状和块状WS2进行了表征。
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引用次数: 0
A novel electromagnetic force method for micro/nano newton force measurement 一种用于微纳牛顿力测量的新型电磁力法
Chongkai Zhou, Yanling Tian, Fujun Wang, Zhiyong Guo, Dawei Zhang
Based on the electromagnetic actuator, a novel mechanical system is developed for the measurement of micro/nano newton force, as well as the deformation of the suspension mechanism. The system mainly includes the electromagnetic actuator, flexible suspension mechanism and displacement sensor. A null position measurement method for the suspension mechanism is introduced. The electromagnetic force is theoretically modeled and simulated in ANSYS Maxwell software to optimize the position of the magnet. And then, the suspension mechanism is simulated by Finite Element Analysis (FEA). According to the experimental results, the developed system has a current resolution 1mA, electromagnetic force conversion rate 400μN/mA, the stiffness 27.5N/m.
基于电磁作动器,设计了一种新型的微纳牛顿力测量系统,并对悬挂机构的变形进行了测量。该系统主要包括电磁执行机构、柔性悬架机构和位移传感器。介绍了一种悬架机构零位测量方法。在ANSYS Maxwell软件中对电磁力进行理论建模和仿真,优化磁体的位置。然后,通过有限元分析对悬架机构进行了仿真。实验结果表明,所研制的系统电流分辨率为1mA,电磁力转化率为400μN/mA,刚度27.5N/m。
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引用次数: 0
The micro hydrogen sensor chip with low power consumption 低功耗微型氢传感器芯片
Hairong Wang, M. Wang, Xiaowei Chen, B. Han
An integrated micro H2 sensor chip with low power consumption is presented. A pair of interdigitated sensing electrodes, sensing layer and heating electrodes surrounding them were designed on the same layer. To realize low power consumption, the silicon substrate with high thermal conduction was released by wet etching and the 1.3#x03BC;m thick membrane with excellent thermal insulation which consists of Si3N4/SiO2/Si3N4/SiO2 four films, was reserved to support the above structure. Annealing was carried out to reduce the stresses of the films. The stacked TiO2/SnO2 composite materials were used to detect H2 and they had six layers consisting of deposited SnO2 and TiO2 through RF magnetron sputtering in turn. The preparation process of the composite materials was combined with the conventional MEMS process to realize mass production of the wafer-level sensor chips with good consistency. The H2 sensor can work steadily for H2 detection (100–900ppm) at 244 °C with low power consumption as 36mW.
提出了一种集成式低功耗微型氢气传感器芯片。在同一层上设计了一对交错的感应电极、感应层和围绕它们的加热电极。为实现低功耗,采用湿法蚀刻法释放高导热硅衬底,并保留由Si3N4/SiO2/Si3N4/SiO2四层膜组成的1.3#x03BC;m厚、隔热性能优良的膜来支撑上述结构。退火是为了降低薄膜的应力。利用堆叠后的TiO2/SnO2复合材料对H2进行检测,通过射频磁控溅射,该复合材料由沉积的SnO2和TiO2依次组成6层。将复合材料的制备工艺与传统MEMS工艺相结合,实现了具有良好一致性的晶圆级传感器芯片的量产。H2传感器可在244°C下稳定工作(100-900ppm),功耗低至36mW。
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引用次数: 0
Narrow-band and polarization cut-offfiltering based on the bionic structure of unidirectional microvilli array 基于单向微绒毛阵列仿生结构的窄带极化截止滤波
Qifan Zhu, Zhiying Liu, Yuegang Fu, Chun-Jie Hao
Based on assumption of the visual system characteristics of the unidirectional microvilli array, this paper simulated the bionic model. The unidirectional microvilli array is simulated and it is simplified as cylinders, which is composed of material with index of refraction of n2 periodically arranged and is surrounded by medium with index of refraction of n1. Then, the bionic structure is equivalent to numbers of binary grating layers with different periods and thicknesses. Based on the effective medium theory (EMT) and transfer matrix method, this paper analyzed the relation between the transmittance of s-and p-modes and wavelengths in visible spectrum (400nm-700nm) for this bionic model. The result shows that the bionic model can work as a polarizer in two different narrow spectral ranges, and in two orthogonal polarization direction and can achieve the function of narrow-band and polarization cut-off filtering. Changing the thicknesses of the binary grating layers, the spectrum band of two spectral ranges would be different.
本文在假设单向微绒毛阵列视觉系统特性的基础上,对仿生模型进行了仿真。对单向微绒毛阵列进行了模拟,并将其简化为圆柱体,由折射率为n2的材料周期性排列,周围是折射率为n1的介质。然后,将仿生结构等效为不同周期和厚度的二元光栅层数。基于有效介质理论(EMT)和传递矩阵法,分析了该仿生模型的- p模式透射率与可见光谱波长(400nm-700nm)之间的关系。结果表明,该仿生模型可以在两个不同的窄光谱范围和两个正交偏振方向上作为偏振器,并能实现窄带滤波和偏振截止滤波的功能。改变二元光栅层的厚度,两个光谱范围的光谱带会有所不同。
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引用次数: 0
Fabrication of size-controlled microstructures of Al alloy surface based on nanosecond laser 基于纳秒激光的铝合金表面尺寸控制微结构制备
Yanling Wan, Lining Xu, Jinkai Xu, Jing Li, Yonghua Wang
Aluminum alloy surface was machined by nanosecond laser equipment, and the effect of different processing parameters on the microstructure of aluminum alloy surface was studied. The surface microstructure was observed by scanning electron microscopy and confocal microscopy. Surface hydrophobicity was evaluated with deionized water. The experiment results show that, by controlling the machining parameters, the surface microstructure morphology can be designed and controlled, at the same time, the influence of processing parameters on microstructure depth and width are also determined.
采用纳秒激光设备对铝合金表面进行加工,研究了不同加工参数对铝合金表面组织的影响。用扫描电镜和共聚焦显微镜观察了表面微观结构。用去离子水评价表面疏水性。实验结果表明,通过控制加工参数,可以设计和控制表面微观组织形态,同时确定加工参数对微观组织深度和宽度的影响。
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引用次数: 0
Anomalous ion transport through hydrophilic and hydrophobic nanopores 通过亲水和疏水纳米孔的异常离子传输
Kun Li, Zhongwu Li, Kabin Lin, Chen Chen, Pinyao He, Jingjie Sha, Yunfei Chen
Nanopores promise wide applications in biosensing, ion-sieve and supercapacitors, ect. However, when the pore diameter approaches nanoscale, ion dynamic properties would deviate from the continuum analysis. In this paper, we reported that ion mobility in a nanopore depended on the surface hydrophobicity of the nanopore material through molecular dynamics (MD) simulation methods. The surface hydrophobicity was regulated by changing the polarity of the Si-N bond and the Van der Waals coefficient. For the nonpolar bond case, the solid-liquid hydrophobic force left an area as expressway for ion and water transport. The ion velocity within 3 Â of the surface was even faster than that in the central diffusion layer. In contrast, for the polar bond case, the strong interaction between the surface charges and the counter ions resulted in the formation of the Stern layer where the velocity of ions as well as water molecules sharply deviated from pore center value. Consequently, the average Na+ velocity in the polar bond nanopore was at least 5 times slower than that in non-polar bond nanopore.
纳米孔在生物传感、离子筛、超级电容器等领域有着广阔的应用前景。然而,当孔径接近纳米尺度时,离子动力学性质将偏离连续统分析。在本文中,我们通过分子动力学(MD)模拟方法报道了离子在纳米孔中的迁移率取决于纳米孔材料的表面疏水性。表面疏水性通过改变Si-N键极性和范德华系数来调节。在非极性键的情况下,固液疏水力留下了一个区域作为离子和水运输的高速公路。表面3 Â内的离子速度比中心扩散层内的离子速度更快。相反,在极性键情况下,表面电荷和反离子之间的强烈相互作用导致Stern层的形成,离子和水分子的速度都急剧偏离孔中心值。因此,极性键纳米孔中的Na+平均速度比非极性键纳米孔中的Na+平均速度慢至少5倍。
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引用次数: 0
Experimental study on cutting characteristics of thin walled structures with weak rigidity 弱刚度薄壁结构切削特性试验研究
Qimeng Liu, Jinkai Xu, Huadong Yu, Zhanjiang Yu, Yiquan Li, Yanling Wan, Xianghui Zhang, Zhongxu Lian
In this paper, the milling experiments of the 7075 Aluminum alloy thin wall specimens are carried out. In the dry cutting under the experimental conditions, the hard alloy cutter the use of the 7075 Aluminum alloy milling can get better quality of the thin-walled specimens, machining, cutting and cutting edge burr and the source, the chip adhesion phenomenon, in the selection of cutting speed for variable conditions, with the increase of cutting speed, milling of thin-walled specimen deformation gradually becomes smaller the thin, the specimen surface residual stress gradually increase, in the selection of feed speed conditions within the range of variables, with the increase of feed speed, the 7075 Aluminum alloy milling of thin-walled specimens. The deformation degree increased, thin specimen surface residual stress decreases gradually, in the selection of cutting depth conditions the range of variables, with the increase of cutting depth, the 7075 Aluminum alloy test milling of thin-walled parts is the greater the degree of deformation, thin-walled specimen surface residual stress was gradually decreased, residual stress the hour gradually thin plate specimens deformation amount is small, the milling of thin-walled specimens after deformation is inevitable.
本文对7075铝合金薄壁试样进行了铣削试验。在干式切削实验条件下,采用硬质合金刀具对7075铝合金进行铣削,可以得到质量较好的薄壁试样,加工过程中,切边毛刺和切屑附着现象的来源及刃口,在选择切削速度为可变条件下,随着切削速度的增加,铣削的薄壁试样变形逐渐变小变薄,试样表面残余应力逐渐增大;在选择进给速度条件的变量范围内,随着进给速度的增大,可铣削7075铝合金薄壁试样。随着变形程度的增加,薄试件表面残余应力逐渐减小,在选择切削深度条件的变量范围内,随着切削深度的增加,7075铝合金试验铣削薄壁件的变形程度越大,薄壁试件表面残余应力逐渐减小,薄板试件变形量小时内残余应力逐渐减小;薄壁试样变形后的铣削是不可避免的。
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引用次数: 0
The effect of loading rate on the measurement of cellular viscoelasticity properties with atomic force microscopy 加载速率对原子力显微镜测定细胞粘弹性的影响
Wenxue Wang, Yuechao Wang, B. Liu, Lianqing Liu, Bo Wang
Organisms are composed by cells, and the cells can also reflect the physiology of creatures. The composition of a single cell and its cytoskeletal structure can be reflected by the mechanical properties of the cell. The cellular mechanical properties are correlated to the biological functions of the cell and its physiological activities. Therefore, establishing the mathematical model for the mechanical properties of single cells could provide the foundation for analyzing and regulating the physiological state of cells. In our previous work, we established a dynamical mathematical model with the viscose and elastic properties of single cells as the system parameters of the cellular system. The mathematical model can characterize the stressrelaxation phenomenon of a single cell, which is caused by an atomic force microscope (AFM). However, in this model, the effect of the loading rate of the AFM cantilever was neglected and all the stress-relaxation curves needed to be measured at a constant loading rate, in case that different loading rates would cause errors in the stress-relaxation curves. In this study, we discussed the effect of the loading rate on the measurement of cellular viscoelasticity properties with AFM. We clearly illustrated that the cellular stress-relaxation curves won't be effected by the loading rate of AFM when the loading rate is higher than a threshold. The stress-relaxation curves with the loading rate which is higher than the threshold can be used to extract viscoelasticity parameters more accurately.
生物体是由细胞组成的,细胞也能反映生物的生理机能。单个细胞的组成及其细胞骨架结构可以通过细胞的力学性能来反映。细胞的力学性质与细胞的生物学功能和生理活动密切相关。因此,建立单细胞力学特性的数学模型可以为分析和调控细胞的生理状态提供基础。在我们之前的工作中,我们建立了一个以单个细胞的粘弹性特性作为细胞系统参数的动力学数学模型。该数学模型可以描述原子力显微镜(AFM)下单个细胞的应力松弛现象。然而,在该模型中,忽略了AFM悬臂梁加载速率的影响,所有应力松弛曲线都需要在恒定加载速率下测量,以免不同的加载速率会导致应力松弛曲线出现误差。在本研究中,我们讨论了加载速率对AFM测量细胞粘弹性性能的影响。结果表明,当AFM加载速率大于某一阈值时,细胞应力松弛曲线不受AFM加载速率的影响。加载速率大于阈值时的应力松弛曲线可以更准确地提取粘弹性参数。
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引用次数: 0
A varying set-point AFM scanning method for simultaneous measurement of sample topography and elasticity 一种同时测量试样形貌和弹性的变设定值AFM扫描方法
Xiaozhe Yuan, Yongchun Fang
Atomic force microscopy (AFM) is a powerful tool for measuring the topography and mechanical properties in nano-scale. The topography of the sample can be achieved by contact mode scanning, while the mechanical properties can be investigated with the help of force curve. However the force curve characterizes the mechanical properties of the sample at a certain point. In many cases, it is important to get the elasticity distribution of the entire surface, which means a huge amount of points need to be selected for measuring force curves. It is obvious that this operation is very time-consuming. As generally known, AFM force curve represents the relationship between the piezo scanner displacement in z-axis and the deflection of the cantilever. Thus the topography images consisted of the vertical displacements of the scanner and the deflection images can be combined to investigate some features of the force curve. The deflection set-point is set to be a time-varying value for increasing the range of scanning data. It is assumed that the elasticity is continuous in a small neighborhood of a scanning point, then a Kalman filter is utilized for conducting data fusion in the neighborhood and estimating the elasticity of the sample.
原子力显微镜(AFM)是在纳米尺度上测量形貌和力学性能的有力工具。试样的形貌可以通过接触模式扫描得到,而力学性能可以借助力曲线进行研究。而力曲线表征的是试样在某一点上的力学性能。在许多情况下,获得整个表面的弹性分布是很重要的,这意味着需要选择大量的点来测量力曲线。很明显,这个操作非常耗时。众所周知,AFM力曲线代表了压电扫描仪在z轴上的位移与悬臂梁挠度之间的关系。这样,由扫描仪的垂直位移和挠度图像组成的地形图像可以结合起来研究力曲线的一些特征。偏转设定值设置为时变值,以增加扫描数据的范围。假设在扫描点的小邻域内弹性是连续的,利用卡尔曼滤波在邻域内进行数据融合,估计样本的弹性。
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引用次数: 1
期刊
2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)
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