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2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)最新文献

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Detection of tip convolution effects based on lateral force analysis 基于侧向力分析的尖端卷积效应检测
Chao Wang, Yongchun Fang
Atomic force microscopy (AFM) has been widely used in various fields due to its excellent performance. Unfortunately the imaging principle of an AFM determines that tip convolution occurs in the scanning process, resulting in image distortion. A model is established to reveal the relationship between the lateral force and the topography of sample surface, and the variation of the lateral force in the tip convolution process is analyzed. On this basis, a method for detecting tip convolution effects based on lateral force analysis is presented. The method uses a specific image to visually represent the distortion areas in the topography image of the sample surface. Experiments show that this method can effectively detect the distortion areas caused by the tip convolution effects in the image.
原子力显微镜(AFM)以其优异的性能被广泛应用于各个领域。不幸的是,AFM的成像原理决定了扫描过程中发生尖端卷积,导致图像畸变。建立了侧向力与试样表面形貌的关系模型,分析了侧向力在尖端卷积过程中的变化规律。在此基础上,提出了一种基于侧向力分析的尖端卷积效应检测方法。该方法使用特定的图像直观地表示样品表面的地形图像中的畸变区域。实验表明,该方法能有效检测出图像中尖端卷积效应引起的畸变区域。
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引用次数: 1
Design and analysis of a large-stroke multi-layer XY compliant nanomanipulator of linear stiffness 线性刚度大行程多层XY柔性纳米机械臂的设计与分析
Mengjia Cui, Zhen Zhang
This paper proposes a multi-layer compliant XY nanomanipulator. Aiming at achieving a large stroke and compact desktop-size, a spatial redundant constraint module in two layers is proposed to restrict parasitic rotations. In addition, a combined Z-shaped beam and multi-beam flexure module is proposed to realize load bearing, and a double parallelogram beam flexure module is utilized to achieve kinematic decoupling. Within the designed stroke, the stiffness of the manipulator behaves linearly. Numerous FEA simulations are conducted to show that the proposed manipulator is able to achieve ±2 × 2 mm2 operation range, and a good agreement between the theoretical analysis and numerical results.
提出了一种多层柔性XY纳米机械臂。为了实现大笔划和紧凑桌面尺寸,提出了一种两层空间冗余约束模块来限制寄生旋转。此外,提出了一种组合z形梁和多梁挠曲模块来实现承载,并利用双平行四边形梁挠曲模块来实现运动解耦。在设计行程内,机械手的刚度呈线性变化。大量的有限元仿真结果表明,该机械手能够实现±2 × 2 mm2的操作范围,理论分析与数值结果吻合良好。
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引用次数: 0
High output piezoelectric composite nanogenerators composed of FAPbBr3-PVDF 由FAPbBr3-PVDF组成的高输出压电复合纳米发电机
B. Han, Xiaohui Ning, Q. Meng, Jin Yan, Chenchen Xie, R. Ding, Zuobin Wang
The FAPbBrc perovskite nanoparticles are applied to mix in PVDF polymer for piezoelectric composite nanogenerators. The FAPbBn-PVDF based piezoelectric nanogenerators exhibit maximum piezoelectric outputs reaching over 29.5 V and 6.15 μA/cm2. The improved performance is attributed to the usage of PVDF polymer which working as the major matrix resulting in enhanced stress on the homogeneously distributed piezoelectric FAPbBn nanoparticles. Then the output piezoelectric signals were utilized to charge capacitances which can lighten purchased LEDs. The work demonstrates an effective approach to develop high-performance energy harvesters based on organometal trihalide perovskite materials.
将FAPbBrc钙钛矿纳米粒子掺入PVDF聚合物中用于压电复合纳米发电机。基于FAPbBn-PVDF的压电纳米发电机的最大压电输出超过29.5 V和6.15 μA/cm2。性能的提高是由于使用PVDF聚合物作为主要基体,使得均匀分布的压电FAPbBn纳米颗粒上的应力增强。然后利用输出的压电信号对电容进行充电,使所购led发光。这项工作展示了一种基于有机金属三卤化物钙钛矿材料开发高性能能量收集器的有效方法。
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引用次数: 0
Detecting the micro/nano physical properties of single lymphoma cells with atomic force microscopy 原子力显微镜检测单个淋巴瘤细胞的微纳物理性质
B. Liu, Mi Li, Bo Wang, Lianqing Liu, Fanan Wei
Non-Hodgkin's lymphoma (NHL) is the most common adult hematological cancer. With the advent of combination therapy of chemotherapy and the monoclonal anti-CD20 antibody Rituximab, the substantial advancement in the treatment of B-cell malignancies has been achieved. In the clinical treatment of NHL, however, there are still many patients who are not sensitive to the therapy of rituximab. Hence investigating the interactions between rituximab and lymphoma cells is crucial for us to understand the actions of rituximab and design drugs with better efficacies. Traditional biochemical methods for cell detection require the various pretreatments of the cell, destroying the structures of cells. This paper uses atomic force microscopy (AFM) to label-free characterize the micro/nano physical properties of single lymphoma cells, including cell morphology, cell elasticity, and molecular interactions on the cell surface. The study improved our understanding of the rituximab actions.
非霍奇金淋巴瘤(NHL)是最常见的成人血液学癌症。随着化疗和单克隆抗cd20抗体利妥昔单抗联合治疗的出现,b细胞恶性肿瘤的治疗取得了实质性进展。然而,在NHL的临床治疗中,仍有许多患者对美罗华治疗不敏感。因此,研究利妥昔单抗与淋巴瘤细胞之间的相互作用,对于我们了解利妥昔单抗的作用,设计出更有效的药物至关重要。传统的细胞检测生化方法需要对细胞进行各种预处理,破坏细胞的结构。本文利用原子力显微镜(AFM)对单个淋巴瘤细胞的微纳物理特性进行了无标记表征,包括细胞形态、细胞弹性和细胞表面的分子相互作用。该研究提高了我们对利妥昔单抗作用的理解。
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引用次数: 0
Micro-fabricated packed metal gas preconcentrator for low detection limit exhaled VOC gas measurements 用于低检测限呼出VOC气体测量的微型制造填充金属气体预富集器
B. Han, Guishan Wu, Hairong Wang, Jiuhong Wang
Gas preconcentrator is critical for many microanalyzer and allows the monitoring of ultra-low concentrations of VOC gas in the sub-ppm level. Especially, it can be used in field test to analyze the low-concentration exhaled VOC gases by improving the gas detection limit for the purpose of noninvasive medical diagnoses. In this paper, a micro metal gas preconcentrator (MGP) was fabricated by using laser etching technology (LET), which is a very powerful means to process more sophisticated and high-quality trenches compared with traditional machining. The preconcentrator chip consists of an array of microchannels that are filled with activeated-car-bon-based sorbent (Carboxen-1000) as the extraction medium. The main structure of chip is made of copper (C11000) because of its good thermal conductivity and small specific heat capacity. Compared with Si substrate, C11000 has better thermal properties, which is advantageous for achieving high concentration factor at relative low power. The copper channel layer is covered with the upper plate of the same material using of vacuum diffusion welding (VDW). At the bottom of the chip the platinum heater is deposited to quickly elevate temperature during its activation and desorption processes. The MGP has flat dimensions of 16 mm × 12.6 mm and a total inner volume about 14.4 μL with no filling the adsorbent granules. The MGP can be connected with GC (Gas chromatography) column and photo ionization detector (PID) to realize ultra-low concentration gas detection.
气体预浓缩器是许多微量分析仪的关键,允许监测超低浓度的挥发性有机化合物气体在ppm以下的水平。特别是可用于现场检测,通过提高气体检测限,对低浓度VOC气体进行分析,达到无创医疗诊断的目的。本文采用激光刻蚀技术(LET)制备了一种微型金属气体预浓缩器(MGP),与传统的加工工艺相比,它是加工更精细、高质量沟槽的有力手段。预富集芯片由微通道阵列组成,微通道中填充了活化碳基吸附剂(Carboxen-1000)作为萃取介质。芯片的主要结构是铜(C11000),因为它的导热性好,比热容小。与Si衬底相比,C11000具有更好的热性能,有利于在相对较低的功率下实现较高的集中系数。采用真空扩散焊(VDW)将铜通道层覆盖在相同材料的上板上。在芯片的底部沉积了铂加热器,以便在其激活和解吸过程中快速提高温度。在不填充吸附剂颗粒的情况下,MGP的平面尺寸为16 mm × 12.6 mm,总内积约为14.4 μL。MGP可与GC(气相色谱)柱和光电离检测器(PID)连接,实现超低浓度气体检测。
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引用次数: 1
Magnetically coupled flextensional transducer for impulsive energy harvesting 用于脉冲能量采集的磁耦合弯张换能器
H. Zou, Wenming Zhang, Wen-Bo Li, G. Meng, Xinsheng Wei, Sen Wang
Impulsive energy is widespread in civil and industrial environment. Energy harvesting from ambient environment is considered as a promising way to replace the conventional batteries for powering wireless autonomous electronic devices. The combination of nonlinear bistable and flextensional mechanisms for impulsive energy harvesting has the advantages of high equivalent piezoelectric constant, high reliability and high sensitivity. The design consists of a cantilever beam with tip magnet and two magnetically coupled flextensional transducers (MCFTs). The coupled dynamical model is provided to describe the electromechanical transition. Experiments and simulations are carried out to evaluate the performances of the harvesters under different impulsive inputs by fingertip. Results verify that the coupled dynamical model can be used to characterize the harvester under impulsive excitation. The magnetically coupled flextensional impulsive energy harvester can work effectively under weak inputs and is reliable and durable under strong inputs.
脉冲能在民用和工业环境中广泛应用。从周围环境中收集能量被认为是替代传统电池为无线自主电子设备供电的一种很有前途的方法。非线性双稳与弯张相结合的脉冲能量收集机构具有高等效压电常数、高可靠性和高灵敏度等优点。该设计由一个带有尖端磁铁的悬臂梁和两个磁耦合伸缩换能器(mcft)组成。给出了描述机电过渡的耦合动力学模型。通过实验和仿真,对不同指尖脉冲输入条件下收割机的性能进行了评价。结果表明,该耦合动力学模型可用于脉冲激励下收割机的特性描述。磁耦合弯张脉冲能量采集器能在弱输入条件下有效工作,在强输入条件下可靠耐用。
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引用次数: 1
Imaging of DNA molecules by atomic force microscope DNA分子的原子力显微镜成像
Fenfen Guo, Feifei Wang, Ying Wang, Wenxiao Zhang, Xinyue Wang, Lu Zhao, Zhengxun Song, Zuobin Wang
This paper explores suitable conditions for the imaging of DNA molecules by atomic force microscope (AFM). As a typical biological macro-molecule, DNA with genetic information has attracted extensive attention, which is an important research subject in molecular biology and biomedicine. In this work, 3-Aminopropyl Triethyl Silane (APTES), Ni2+ and Mg2+ were used to modify the surface of mica substrate, and DNA molecules were adhered to the mica surface through the physical interaction of charges. The DNA molecules were imaged using an AFM under both air and liquid conditions. By analyzing the images of DNA molecules obtained in the experiments, it was found that the mica surface modified with Ni2+ had the best imaging quality under the liquid condition. This work will be useful for the study of high quality AFM imaging of DNA molecules, and the manipulation of DNA molecules by AFM mechanical forces.
本文探讨了原子力显微镜(AFM)成像DNA分子的适宜条件。作为一种典型的生物大分子,具有遗传信息的DNA受到了广泛的关注,是分子生物学和生物医学领域的重要研究课题。本研究利用3-氨基丙基三乙基硅烷(APTES)、Ni2+和Mg2+对云母基质表面进行修饰,DNA分子通过电荷的物理相互作用粘附在云母表面。DNA分子在空气和液体条件下使用原子力显微镜成像。通过对实验中获得的DNA分子图像进行分析,发现用Ni2+修饰的云母表面在液体条件下具有最好的成像质量。这项工作将有助于研究高质量的DNA分子AFM成像,以及利用AFM机械力操纵DNA分子。
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引用次数: 1
Double layer nanopore fabricated by FIB and TEM 用FIB和TEM制备双层纳米孔
Haojie Yang, Wei Si, Jingjie Sha, Yunfei Chen, Xiao Xie, Anping Ji
In order to support the third generation DNA sequencing technique, a double layers nanopore consisting of silicon nitride (Si3N4) and graphene is fabricated in this paper. Firstly, high yield Si3N4 nanofilm chips were manufactured successfully after SißNt deposition, etching and release process. Then, focused ion beam (FIB) was used to manufacture SißNi nanopore on Si3N4 nanofilm chips with optimized process. The graphene sheet was synthesized with chemical vapor deposition (CVD) method and transferred onto the Si3N4 membrane milling area. We use transmission electron microscope (TEM) to fabricate the nanopore in the graphene membrane above the center of the Si3N4 nanopore. The diameter of SißNt layer was characterized to be 28 nm and the diameter of graphene nanopore was 4 nm which is fabricated by FIB and electron beam respectively. This method provides a useful tool to nanopore-based DNA sequence.
为了支持第三代DNA测序技术,本文制备了由氮化硅(Si3N4)和石墨烯组成的双层纳米孔。首先,通过SißNt沉积、蚀刻和释放工艺,成功制备出高产量的Si3N4纳米膜芯片。然后,利用聚焦离子束(FIB)优化工艺,在Si3N4纳米膜芯片上制备SißNi纳米孔。采用化学气相沉积(CVD)法制备了石墨烯薄片,并将其转移到氮化硅制膜区。利用透射电子显微镜(TEM)在氮化硅纳米孔中心上方的石墨烯膜上制备了纳米孔。采用FIB法和电子束法制备的SißNt层直径为28 nm,石墨烯纳米孔直径为4 nm。该方法为基于纳米孔的DNA测序提供了一种有用的工具。
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引用次数: 1
Fluidic simulation and analysis of spiral, U-shape and curvilinear nano channels for biomedical application 生物医学应用中螺旋、u形和曲线纳米通道的流体模拟与分析
M. Afzal, S. Tayyaba, Fazal-e-Aleem, M. Ashraf, M. Khalid Hossain, N. Afzulpurkar
This research work presents the simulation and analysis of blood flow in tortuous veins. Three different sized nano channels like spiral, u-shape and curvilinear have been simulated using ANSYS FLUENT. The radius of 200 nm has been considered for all channels during simulation. Flow rate and velocity of these channels have been determined. For spiral, U-shape and curvilinear channels, the flow rate and velocity of 236 pL/s and 18.73 cm/s, 245 pL/s and 19.45 cm/s and 248.8 pL/s and 19.75 cm/s have been observed respectively.
这项研究工作是对弯曲静脉血流的模拟和分析。利用ANSYS FLUENT软件对螺旋形、u形和曲线形三种不同尺寸的纳米通道进行了数值模拟。仿真中考虑了所有通道的半径为200nm。测定了这些通道的流量和流速。螺旋、u形和曲线通道的流速和速度分别为236 pL/s和18.73 cm/s, 245 pL/s和19.45 cm/s, 248.8 pL/s和19.75 cm/s。
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引用次数: 5
Control of particle size in energetic drop-on-demand inkjet method 高能按需滴墨法中粒径的控制
Ruirui Zhang, Jun Luo, Hongcheng Lian, Haobo Liu, L. Qi
Nano-energetic materials have attracted the worldwide attention since they play an important role in fabricating insensitive high-energy explosives, microenergetic devices, and explosive detectors. However, applications of nano-energetic materials are still limited by the low loading accuracy, material-wasting, and complicated steps. To solve this problem, the drop-on-demand inkjet method is proposed to precisely print energetic droplets. We expect to achieve energetic materials with nanoscale particles by integrating the deposition and the nanocrystallization of energetic droplets in one step. A proprietary uniform energetic micro-droplet printing equipment is utilized to reveal the influence of temperature and frequency on the particle size of energetic materials. Finally, a uniform line, with the particle size between nanometer and microns, is successfully obtained, showing the feasibility of the proposed method for preparing the micro scale charge of nano-energetic materials.
纳米能材料在制造不敏感高能炸药、微能器件和炸药探测器等方面发挥着重要作用,引起了世界各国的广泛关注。然而,纳米能量材料的应用仍然受到装载精度低、材料浪费和步骤复杂等问题的限制。为了解决这一问题,提出了按需喷墨法精确打印高能液滴。我们期望通过将能滴的沉积和纳米晶化在一个步骤中结合起来,获得具有纳米级粒子的能材料。利用专有的均匀高能微滴打印设备,揭示了温度和频率对含能材料粒径的影响。最后,成功地获得了一条粒径介于纳米和微米之间的均匀线,证明了该方法制备纳米含能材料微尺度电荷的可行性。
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引用次数: 2
期刊
2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)
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