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2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)最新文献

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Digital Read-Out Modules of CRYO System-an-Chip ASIC for Cryogenic TPC Detectors 低温TPC探测器用低温系统单片ASIC数字读出模块
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9508032
Aseem Gupta, A. Pena-Perez, B. Markovic, C. Tamma, D. Doering, Hussein Ali, Umanath Kamath, P. Caragiulo, L. Rota, S. Petrignani, Xiaobin Xu, F. Abu-Nimeh, B. Reese, A. Dragone
This work describes the primary modules of the digital read-out system implemented in a System-On-Chip (SoC) ASIC optimized for noble liquid Time Projection Chambers (TPCs). The ASIC, referred here as CRYO, performs digital and analog functions and has been designed as the charge read-out system for neutrino science experiments. The digital back-end of the chip provides data throughput up to 1 Gbps and operates with cryogenic liquids (Liquid Xenon, 160 K and Liquid Argon, 87 K). The ASIC is fabricated with 130 nm CMOS technology and the read-out process implements a sequential digital multiplexer, a custom encoder, a high-speed serializer, and LVDS (Low-Voltage Differential Signaling) drivers assisted with pre-emphasis techniques to preserve signal integrity up to 25 m cable length. The back-end system is fully programmable through a dedicated slow control unit interface to operate across temperatures and different cable lengths. A subset of simulation results of the readout of CRYO at target temperatures are validated using a custom verification flow.
这项工作描述了数字读出系统的主要模块,该系统实现在针对高贵液体时间投影室(TPCs)优化的片上系统(SoC) ASIC中。ASIC,在这里被称为CRYO,执行数字和模拟功能,并被设计为中微子科学实验的电荷读出系统。芯片的数字后端提供高达1 Gbps的数据吞吐量,并在低温液体(液态氙,160 K和液态氩气,87 K)下运行。ASIC采用130 nm CMOS技术制造,读出过程实现了顺序数字多路复用器、定制编码器、高速串行化器和LVDS(低压差分信号)驱动器,辅以预强调技术,以保持长达25米电缆长度的信号完整性。后端系统通过专用的慢速控制单元接口完全可编程,可以在不同温度和不同电缆长度下运行。使用自定义验证流程验证了目标温度下CRYO读数的模拟结果子集。
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引用次数: 0
Multigrid Reconstruction Technique for X-ray Fluorescence Computed Tomography x射线荧光计算机断层扫描的多网格重建技术
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507913
Bo Gao, L. Van Hoorebeke, L. Vincze, M. Boone
X-ray Fluorescence Computed Tomography (XFCT) is an imaging modality aiming at mapping the elemental distribution inside the sample non-invasively. However, the self-absorption effect associated with XFCT makes the accurate reconstruction challenging. To solve this issue, reconstruction algorithms that compensates this effect have been proposed. Due to the computational complexity, almost all algorithms proposed for XFCT reconstruction have modelled XFCT in a 2D plane, which is an approximation only accurate in limited cases. In this manuscript, the limitation of modelling XFCT in a 2D plane is demonstrated. Then, an effective method for the acceleration of XFCT reconstruction in the 3D space, namely multigrid XFCT reconstruction, is proposed. Specifically, multigrid refers to the different discretization grids, on which the elemental distributions and the attenuation coefficients at the energies of fluorescence X-rays are reconstructed. Through test, it can be shown that an accurate density distribution could be obtained even if the attenuation coefficients have been reconstructed on a coarser grid. As the multigrid reconstruction strategy is independent of the methodology behind the reconstruction algorithms, it could be used to accelerate all XFCT reconstruction algorithms that simultaneously reconstruct the elemental density and the attenuation coefficients at the energies of fluorescence X-rays.
x射线荧光计算机断层扫描(XFCT)是一种旨在无创性地绘制样品内部元素分布的成像方式。然而,与XFCT相关的自吸收效应使得精确重建具有挑战性。为了解决这一问题,已经提出了补偿这一影响的重建算法。由于计算的复杂性,几乎所有提出的XFCT重建算法都是在二维平面上对XFCT进行建模,这种近似只在有限的情况下是准确的。在这篇手稿中,XFCT在二维平面上建模的局限性被证明。然后,提出了一种在三维空间加速XFCT重建的有效方法,即多网格XFCT重建。具体来说,多重网格是指在不同的离散网格上重建荧光x射线能量处的元素分布和衰减系数。试验表明,即使在较粗的网格上重构衰减系数,也能得到较精确的密度分布。由于多重网格重建策略独立于重建算法背后的方法,它可以用来加速所有同时重建荧光x射线能量下元素密度和衰减系数的XFCT重建算法。
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引用次数: 0
Compton Camera Imaging Sensitivity with Improved Event Selection 康普顿相机成像灵敏度与改进的事件选择
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507802
M. Mikeli, Mina-Ermioni Tomazinaki, E. Stiliaris
Besides the noiseless extraction of the energy deposited in the absorber, an ideal event reconstruction in a Compton-Camera system requires the accurate determination of both interaction points in the scatterer and absorber. Limited energy and spatial resolution of the system combined with other misidentification effects leads frequently to the acceptance of faulty events, which affect the quality of the reconstructed image. Based on GEANT4/GATE simulation studies, a filtering procedure to eliminate energy and spatially unbalanced events is proposed in the current work. Attention has been paid to exclude from the coincidence selection procedure events that alternate the normal interaction sequence in the scatterer-absorber subsystems or violate total energy sum rules. Following the proposed filtering approach, volume effects traced back to the angular acceptance of a two-stage Compton-Camera system are systematically investigated and a normalization-correction technique to improve the performance of the system for phantoms with out-of-plane sources is presented.
在康普顿-照相机系统中,除了对吸收体中沉积的能量进行无噪声提取外,理想的事件重建还需要准确地确定散射体和吸收体中的相互作用点。由于系统能量和空间分辨率有限,再加上其他误识别效应,导致系统经常接受错误事件,从而影响重构图像的质量。基于GEANT4/GATE仿真研究,提出了一种消除能量和空间不平衡事件的滤波方法。注意从偶合选择程序中排除那些在散射-吸收子系统中改变正常相互作用顺序或违反总能量和规则的事件。根据提出的滤波方法,系统地研究了可追溯到两级康普顿相机系统的角度接受的体积效应,并提出了一种归一化校正技术,以提高系统对面外光源的幻影的性能。
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引用次数: 2
Hybrid Spectral and Image Deconvolution for High-Resolution CZT Imaging Spectrometers 高分辨率CZT成像光谱仪的混合光谱和图像反卷积
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9508056
C. Wahl, S. Brown, B. Kitchen, Weiyi Wang, W. Kaye
Large-volume 3D-position-sensitive CdZnTe is used in many applications for spectroscopy and Compton imaging. Being able to determine the incident gamma-ray flux, as a function of both the energy and direction, is, of course, a useful feature to provide more information from each measurement. Deconvolution in the energy domain should be able to identify emission lines and continuous distributions over energy. Deconvolution in the direction domain should be able to identify point sources and distributed sources. In this work, a hybrid deconvolution method is introduced, which uses the image to improve the spectral deconvolution and the spectrum to improve the image deconvolution, while still being fast enough to run on practical problems. Details of the deconvolution method are presented along with representative results.
大体积3d位置敏感CdZnTe用于光谱学和康普顿成像的许多应用。能够确定入射伽马射线通量,作为能量和方向的函数,当然是一个有用的特征,可以从每次测量中提供更多的信息。能量域中的反褶积应该能够识别发射线和能量上的连续分布。方向域中的反褶积应该能够识别点源和分布源。本文提出了一种混合反褶积方法,即利用图像改进光谱反褶积,利用频谱改进图像反褶积,同时速度足够快,可以在实际问题中运行。详细介绍了反褶积方法,并给出了代表性的结果。
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引用次数: 0
A Novel Concept for PET Scanners Design using Polaroid-based Detectors for Filtering Reflected Optical Photons 利用宝丽来探测器过滤反射光子的PET扫描仪设计新概念
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9508069
Amirhossein Sanaat, Aydin Ashrafi-Belgabad, H. Zaidi
The aim of this work is to propose and assess a new detector module for an animal PET scanner, called Polaroid-PET. Polaroid-PET's detector modules consist of monolithic crystals on which a layer of Polaroid sheet is stick on one side to filter unpolarized optical photons. The polaroid sheet filter reflects optical photons and thus enhances the spatial resolution in the detector module based on monolithic scintillator crystals. In the initial step, the GEANT4 Monte Carlo toolkit is used to simulate a detector block consisting of a lutecium-based monolithic crystal (LYSO) with a crystal thickness of 10 mm and semiconductor-based Silicon Photomultipliers. A Polaroid sheet was placed between the crystal and the SiPMs to block unpolarized photons come from the crystal. In the next step, two preclinical PET scanners with and without Polaroid based on 10 detector modules were simulated. The performance of the two detector modules and preclinical PET scanners were assessed by calculating the spatial resolution, and depth of interaction (DOI). The Polaroid-equipped detector module resulted in a better spatial resolution with ~1.05 mm full-width at half maximum (FWHM) compared with the regular detector (~1.3 mm FHWM) for a point source placed in front of the center of the detector's entrance face. Our Polaroid-based PET scanner led to better axial spatial resolution in comparison with the regular small-animal PET scanner for a point source placed at the center of the field-of-view (0.83 mm vs. 1.01 mm FWHM). By filtering reflected unpolarized optical photons, Polaroid-PET was able to achieve improved spatial resolution and sensitivity compared to the original design.
这项工作的目的是提出并评估一种新的检测器模块,用于动物PET扫描仪,称为宝丽来PET。宝丽来pet的探测器模块由单片晶体组成,单片晶体的一侧粘着一层宝丽来片来过滤非偏振光子。偏振片滤光片反射光子,从而提高了基于单片闪烁晶体的探测器模块的空间分辨率。在初始步骤中,使用GEANT4蒙特卡罗工具包模拟由晶体厚度为10 mm的基于镥的单片晶体(LYSO)和基于半导体的硅光电倍增管组成的探测器块。在晶体和sipm之间放置了一个宝丽来片,以阻止来自晶体的非偏振光子。在接下来的步骤中,分别模拟了两台基于10个检测器模块的有宝丽来和没有宝丽来的临床前PET扫描仪。通过计算空间分辨率和相互作用深度(DOI)来评估两个检测器模块和临床前PET扫描仪的性能。对于放置在探测器入口面中心前的点源,配备宝丽来的探测器模块与普通探测器(~1.3 mm FHWM)相比,获得了更好的空间分辨率,达到了~1.05 mm的半最大全宽(FWHM)。与常规的小动物PET扫描仪相比,我们基于宝丽来的PET扫描仪在视场中心放置的点源(0.83 mm vs 1.01 mm FWHM)具有更好的轴向空间分辨率。通过过滤反射的非偏振光子,与原始设计相比,宝丽来pet能够实现更高的空间分辨率和灵敏度。
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引用次数: 0
Measurement of Discharge Events Due to Voltage Breakdown in High-Voltage Ceramic Feedthroughs 高压陶瓷馈线中电压击穿放电事件的测量
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507934
E. Yamamoto, S. Shermer, A. Hutchinson
Ceramic insulated hermetic feedthroughs are used as signal and high-voltage conduits for sealed gamma radiation detectors with applications in oil and gas exploration. In configurations where signal and high-voltage are supplied via the same feedthrough, voltage breakdown of the gas filling the gap between the conducting wire and coaxial ceramic insulator may produce a charge pulse that is indistinguishable from a gamma detection pulse. This work describes a method to measure the discrete pulses generated by discharges across an air gap between a conducting wire and a coaxial ceramic insulator at 1600V and 150C ambient temperature. The data presented show results of measurements from discrete discharge events containing between ~0.5 pico-Coulombs and 200 pico-Coulombs of charge per event. Samples were tested that had undergone various operations including welding and soldering. Different cleaning operations were applied to some samples to determine whether discharges could be attributed to surface contamination. Measurements of samples where the ceramic insulator was manufactured using two different forming processes was also performed. This method is shown to provide a sensitive tool to screen hermetic components in radiation detectors used for oil and gas exploration.
陶瓷绝缘密封馈线作为信号和高压管道,用于密封伽马辐射探测器,在石油和天然气勘探中的应用。在信号和高压通过同一馈通提供的配置中,填充导线和同轴陶瓷绝缘体之间空隙的气体的电压击穿可能产生与伽马探测脉冲难以区分的电荷脉冲。这项工作描述了一种在1600V和150C环境温度下测量导线和同轴陶瓷绝缘体之间的气隙放电产生的离散脉冲的方法。所提供的数据显示了对离散放电事件的测量结果,每个事件的电荷在~0.5皮库仑到200皮库仑之间。测试的样品经过了各种操作,包括焊接和焊接。不同的清洗操作应用于一些样品,以确定排放是否可归因于表面污染。对陶瓷绝缘体采用两种不同成型工艺制造的样品进行了测量。该方法被证明为筛选用于石油和天然气勘探的辐射探测器中的密封元件提供了一种灵敏的工具。
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引用次数: 0
A High-performance Onboard Small Animal PET for Preclinical Radiotherapy Research 一种用于临床前放疗研究的高性能机载小动物PET
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507964
Xinyi Cheng, K. Hu, Dongxu Yang, Y. Shao
We have developed and evaluated a prototype animal PET dedicated for PET/CT/RT. It consists of 12 detectors configured in a dodecagon; each panel has a 30x30 array of 1x1x20 mm3 LYSO scintillators with each end of the scintillator array optically connected to Silicon Photomultiplier (SiPM) arrays for depth-of-interaction (DOI) measurement. The trans-axial and axial field-of-view (FOV) are ~10 cm in diameter and 3.5 cm long. PCB and FPGA based detector readout and processing electronics has been developed. Preliminary system and imaging performances were evaluated with a Na-22 point source and a F-18 ultra-micro hot-rod phantom. The energy, DOI, and coincidence timing resolutions of the system are around 23%, 3.2 mm, and 4.88 ns, respectively. The measured system sensitivity is ~2.2% at the center of FOV, and the image resolution measured from the reconstructed point source images over the FOV ranges from 0.77 to 1.03 mm (mean 0.83 mm). Hot-rods with diameters from 1.0 to 2.4 mm are well separated on the reconstructed phantom image when DOI is applied.
我们已经开发并评估了一种用于PET/CT/RT的动物PET原型。它由12个探测器组成,呈十二角形;每个面板都有一个30x30的1x1x20mm3的LYSO闪烁体阵列,闪烁体阵列的每一端光学连接到硅光电倍增管(SiPM)阵列,用于相互作用深度(DOI)测量。跨轴和轴向视场(FOV)直径约10厘米,长3.5厘米。基于PCB和FPGA的检测器读出和处理电子器件已经开发出来。采用Na-22点源和F-18超微热杆模体对系统和成像性能进行了初步评估。系统的能量分辨率约为23%,DOI约为3.2 mm,符合时序分辨率约为4.88 ns。在视场中心测得的系统灵敏度为~2.2%,在视场中心测得的重构点源图像分辨率范围为0.77 ~ 1.03 mm(平均0.83 mm)。当应用DOI时,直径为1.0 ~ 2.4 mm的热棒在重建的幻影图像上分离得很好。
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引用次数: 0
Wireless Sensor Platform for Dry Spent Fuel Cask Monitoring 干乏燃料桶监测无线传感器平台
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9508083
D. McAdams, Erik B. Johnson, M. Squillante, Andrew Harrington, R. Blakeley, E. Weststrate, Jane He, S. Bader, J. Christian
Nuclear power plants regularly generate spent fuel that must be stored on the decade timescale. Often this is done in dry nuclear waste storage casks. Long-term monitoring would provide data that improves the safe maintenance of stored spent fuel. This requires measuring the conditions within waste casks using a self-contained sensor system. Radiation Monitoring Devices, Inc. is developing a system that detects damaged fuel rod cladding by sensing and quantifying the amount of 85Kr present using a diamond sensor. A potential means for power and data transfer through the cask wall uses an ultrasonic transmission method. The work described here advances the prototype toward inclusion in a specific model fuel cask, the NUHOMS® 32 PTH1 manufactured by Orano (formally, Areva Transnuclear, Inc.). The results include extensive radiological modeling studies, an estimation of the leaked activity due to 85Kr after a cladding breach (~ 1013Bq) derived from a literature review, a design for a prototype, and the characterization of a diamond detector at room temperature and in the presence of 85Kr.
核电站定期产生的乏燃料必须以十年为周期进行储存。这通常是在干燥的核废料储存桶中完成的。长期监测将提供数据,以改进储存的乏燃料的安全维护。这需要使用一个独立的传感器系统来测量废物桶内的条件。辐射监测设备公司正在开发一种系统,该系统通过使用钻石传感器感应和量化85氪的含量来检测受损的燃料棒包层。通过桶壁进行功率和数据传输的一种潜在手段是使用超声波传输方法。这里所描述的工作将原型推进到包含在特定模型燃料桶中,由Orano(正式名称为Areva Transnuclear, Inc.)制造的NUHOMS®32 PTH1。结果包括广泛的放射学建模研究,根据文献综述对包层破裂(~ 1013Bq)后85Kr泄漏活度的估计,原型设计,以及在室温和85Kr存在下的金刚石探测器的表征。
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引用次数: 0
Radioisotope Identification with Scintillation Detector Based on Artificial Neural Networks Using Simulated Training Data 基于模拟训练数据的人工神经网络闪烁探测器放射性同位素识别
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507888
Peng Fan, Siliang Feng, Chenglin Zhu, Chunqing Zhao, Y. Ding, Zicai Shen, Yaqiang Liu, Tianyu Ma, Y. Xia
Artificial neural networks (ANN) based on learning the features of the entire measured gamma energy spectrum has been used for radioisotope identification and proved promising especially for gamma-ray spectroscopy with low energy resolution. The implementation of ANN method, however, requires tedious experimental measurement process in generation of training data for various radioisotopes. In this work, we propose an ANN-based radioisotope identification method with simulated training data. Gamma energy spectra of 27 different radioisotopes were generated with Monte Carlo simulation. A detector energy response model was proposed to match the energy spectra generated from simulation and measured from experiment, thus “pseudo” measured energy spectra of various radioisotopes transformed from simulation can be used for ANN training, which eliminates the tedious experimental measurement process for training data generation. To reduce the complexity of the training process, the principal component analysis (PCA) method was used for dimension reduction of the input energy spectra in ANN and the channel number of the energy spectra was reduced from 2000 to 50. The trained ANN was further used to identify experimentally measured gamma energy spectra of various radioisotopes including 60Co., 137CS., 18F, 131I, 226Ra and 232Th at 103, 104 and 105 count levels. In single isotope identification test, with increased count level, higher correct identification rate is achieved and at 105 count level, all the isotopes are correctly identified for all the samples. In mixed isotope identification test, at 105 count level, all the radioisotope combinations can be identified with a correct identification rate larger than 98%, which demonstrates the feasibility and accuracy of the ANN method. To conclude, the proposed ANN method with simulated training data features good radioisotope identification capability with greatly simplified training data generation process and is feasible for gamma spectroscopy with relatively poor energy resolution.
基于学习整个测量伽马能谱特征的人工神经网络(ANN)已被用于放射性同位素识别,特别是在低能量分辨率的伽马射线能谱中被证明是有前途的。然而,人工神经网络方法的实施需要繁琐的实验测量过程来生成各种放射性同位素的训练数据。在这项工作中,我们提出了一种基于人工神经网络的模拟训练数据的放射性同位素识别方法。用蒙特卡罗模拟生成了27种不同放射性同位素的γ能谱。提出了一种探测器能量响应模型,将模拟生成的能谱与实验测量的能谱进行匹配,从而将模拟生成的各种放射性同位素的“伪”测量能谱用于人工神经网络训练,从而消除了训练数据生成过程中繁琐的实验测量过程。为了降低训练过程的复杂性,采用主成分分析(PCA)方法对神经网络输入的能谱进行降维,并将能谱的通道数从2000个降为50个。训练后的人工神经网络进一步用于识别包括60Co在内的各种放射性同位素的实验测量γ能谱。137 cs。, 18F, 131I, 226Ra和232Th计数水平为103,104和105。在单同位素鉴定试验中,随着计数水平的增加,正确率更高,在105计数水平下,所有样品的所有同位素都被正确鉴定。在混合同位素鉴定试验中,在105个计数水平下,所有放射性同位素组合的正确率均大于98%,证明了人工神经网络方法的可行性和准确性。综上所述,基于模拟训练数据的人工神经网络方法具有良好的放射性同位素识别能力,大大简化了训练数据生成过程,对于能量分辨率相对较差的伽马能谱也是可行的。
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引用次数: 0
Spatial Registration of Neuroimaging Data: Analysis of the Convenience of Performing Non-Affine Transformations 神经影像数据的空间配准:执行非仿射变换的便利性分析
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507925
F. Bayo, D. Castillo-Barnes, D. Salas-González, C. Jiménez-Mesa, J. Górriz, J. Ramírez, F. Segovia
Computer-based analysis of neuroimaging data in multisubject studies requires a previous spatial registration procedure, which ensures that the same voxel across different images refers to the same anatomical position. Several algorithms have been proposed to this end and most of them perform the spatial registration in two steps, an affine transformation followed by a non-linear registration. While the former applies only translations, rotations, zoom and shears to the neuroimages, the non-linear registration step can deform them to adjust the size and shape of individual regions. Although the scientific community generally accepts that these transformations are necessary, even though they may introduce certain distortions (noise), some recent works indicate that it is preferable to perform the spatial registration as an affine transformation only, in order to prevent the non-linear registration from removing information that could be relevant in the further analysis. In this work we evaluated the influence of applying nonlinear transformations during the special registration of molecular neuroimages that will be used in computer systems intended to assist the diagnosis of neurodegenerative disorders. Specifically, we compared the performance of a Support Vector Machine classifier that used data spatially registered using only affine transformations and other one that used data that have been registered using the classical procedure, which includes non-linear transformations. Two datasets were considered, one intended to assist the diagnosis of Alzheimer's disease and other one intended to assist the diagnosis of Parkinsonism. The results suggest that non-linear transformations facilitate the subsequent classification and provide slightly higher accuracy rates. The different is more important with data in which the intensity is concentrated in a small target region such as DatSCAN neuroimages, used to assist the diagnosis of Parkinsonism.
在多学科研究中,基于计算机的神经成像数据分析需要先前的空间配准程序,以确保不同图像中的相同体素指的是相同的解剖位置。为此提出了几种算法,大多数算法分两步进行空间配准,即仿射变换和非线性配准。前者只对神经图像进行平移、旋转、缩放和剪切,而非线性配准步骤可以对神经图像进行变形,以调整单个区域的大小和形状。尽管科学界普遍认为这些变换是必要的,尽管它们可能会引入某些失真(噪声),但最近的一些研究表明,为了防止非线性配准去除可能在进一步分析中相关的信息,最好只将空间配准作为仿射变换进行。在这项工作中,我们评估了在分子神经图像的特殊注册过程中应用非线性变换的影响,这些图像将用于计算机系统,旨在协助诊断神经退行性疾病。具体来说,我们比较了仅使用仿射变换在空间上注册数据的支持向量机分类器和使用经典过程(包括非线性变换)注册数据的支持向量机分类器的性能。考虑了两个数据集,一个旨在协助阿尔茨海默病的诊断,另一个旨在协助帕金森病的诊断。结果表明,非线性变换有利于后续分类,并提供略高的准确率。这种差异在数据中更为重要,这些数据的强度集中在一个小的目标区域,比如用于辅助帕金森病诊断的DatSCAN神经图像。
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引用次数: 0
期刊
2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
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