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Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis 用于脊柱转移瘤止血和抗癌治疗的可注射纳米机器人-水凝胶超结构。
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2024-08-01 DOI: 10.1007/s40820-024-01469-3
Qing Chen, Miao Yan, Annan Hu, Bing Liang, Hongwei Lu, Lei Zhou, Yiqun Ma, Chao Jia, Dihan Su, Biao Kong, Wei Hong, Libo Jiang, Jian Dong

Surgery remains the standard treatment for spinal metastasis. However, uncontrolled intraoperative bleeding poses a significant challenge for adequate surgical resection and compromises surgical outcomes. In this study, we develop a thrombin (Thr)-loaded nanorobot-hydrogel hybrid superstructure by incorporating nanorobots into regenerated silk fibroin nanofibril hydrogels. This superstructure with superior thixotropic properties is injected percutaneously and dispersed into the spinal metastasis of hepatocellular carcinoma (HCC) with easy bleeding characteristics, before spinal surgery in a mouse model. Under near-infrared irradiation, the self-motile nanorobots penetrate into the deep spinal tumor, releasing Thr in a controlled manner. Thr-induced thrombosis effectively blocks the tumor vasculature and reduces bleeding, inhibiting tumor growth and postoperative recurrence with Au nanorod-mediated photothermal therapy. Our minimally invasive treatment platform provides a novel preoperative therapeutic strategy for HCC spinal metastasis effectively controlling intraoperative bleeding and tumor growth, with potentially reduced surgical complications and enhanced operative outcomes.

手术仍然是治疗脊柱转移瘤的标准方法。然而,无法控制的术中出血对充分的手术切除构成了巨大挑战,并影响手术效果。在这项研究中,我们将纳米机器人融入再生丝纤维蛋白纳米纤维水凝胶中,开发出一种凝血酶(Thr)负载纳米机器人-水凝胶混合上层结构。在小鼠脊柱手术前,经皮注射这种具有卓越触变性能的超结构,并将其分散到具有易出血特性的肝细胞癌(HCC)脊柱转移灶中。在近红外照射下,自运动纳米机器人穿透脊柱深部肿瘤,以可控方式释放 Thr。Thr诱导的血栓形成可有效阻断肿瘤血管并减少出血,通过金纳米棒介导的光热疗法抑制肿瘤生长和术后复发。我们的微创治疗平台为 HCC 脊柱转移提供了一种新的术前治疗策略,可有效控制术中出血和肿瘤生长,减少手术并发症,提高手术效果。
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引用次数: 0
Boosting High-Voltage Practical Lithium Metal Batteries with Tailored Additives 利用定制添加剂提高高压实用金属锂电池的性能。
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2024-07-29 DOI: 10.1007/s40820-024-01479-1
Jinhai You, Qiong Wang, Runhong Wei, Li Deng, Yiyang Hu, Li Niu, Jingkai Wang, Xiaomei Zheng, Junwei Li, Yao Zhou, Jun-Tao Li

Highlights

  • FGN-182 electrolytes exhibit highly reversible Li plating/stripping with an average Coulombic efficiency reaching up to 99.56% determined from Auerbach’s test.

  • The gas-evolution process of LiNO3 in high-voltage lithium cobalt oxide (LCO) cathodes is revealed by in situ differential electrochemical mass spectrometry.

  • Pouch cells equipped with high-loading LCO (3 mAh cm−2) cathodes, ultrathin Li chips (25 μm), and lean electrolytes (5 g Ah−1) using optimized electrolyte (FGN-182 + 1%HTCN) demonstrate outstanding cycling performance.

锂(Li)金属阳极被广泛认为是高能量密度电池的理想阳极材料。然而,不受控制的锂枝晶生长往往会导致不利的界面和较低的库仑效率(CE),从而限制了其更广泛的应用。本文制备了一种醚基电解质(称为 FGN-182),通过掺入 LiFSI 和 LiNO3 作为双盐,展示了超稳定的锂金属阳极。双盐的协同效应促进了具有快速 Li+ 传输动力学的高稳定性 SEI 膜的形成。值得注意的是,Li||Cu 半电池的平均 CE 值高达 99.56%。特别是,配备了高负载氧化钴锂(LCO,3 mAh cm-2)阴极、超薄锂芯片(25 μm)和贫电解质(5 g Ah-1)的袋式电池表现出卓越的循环性能,在 125 个循环后仍能保持 80% 的容量。为了解决高电压下阴极中的气体问题,在 FGN-182 中加入了阴极添加剂 1,3,6-三氰基己烷;由此产生的高电压 LCO||Li (4.4 V) 袋式电池可以稳定地循环 93 个周期。这项研究表明,即使使用醚基电解质,通过探索阴极和阳极的适当功能添加剂,也可以同时显著提高锂的高利用率和电解质对高压的耐受性。
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引用次数: 0
Constructed Mott–Schottky Heterostructure Catalyst to Trigger Interface Disturbance and Manipulate Redox Kinetics in Li-O2 Battery 构建莫特-肖特基异质结构催化剂,以引发界面扰动并操纵锂-O2 电池中的氧化还原动力学。
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2024-07-29 DOI: 10.1007/s40820-024-01476-4
Yongji Xia, Le Wang, Guiyang Gao, Tianle Mao, Zhenjia Wang, Xuefeng Jin, Zheyu Hong, Jiajia Han, Dong-Liang Peng, Guanghui Yue

Highlights

  • A carbon free self supported Mott-Schottky heterostructure was constructed as an efficient cathode catalyst for lithium oxygen batteries, achieving homogeneous contact between the two materials for strong interfacial interactions.

  • The heterostructure triggered interfacial perturbations and band structure changes, which accelerated oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) kinetics, resulting in an extremely long cycle life of 800 cycles and an extremely low overpotential of 0.73 V.

  • Combined with advanced characterization techniques and density functional theory calculations, the underlying mechanism behind the boosted ORR/OER activities and the electrocatalytic mechanism were revealed.

具有高能量密度的锂氧电池(LOB)是一种前景广阔的先进储能技术。然而,在循环过程中,缓慢的阴极氧化还原动力学会导致放电产物不能及时分解,从而产生较大的极化,使电池在短时间内失效。因此,我们在钛纸(TP-NCO/MO)上巧妙地设计了一种具有莫特-肖特基异质结构的自支撑互连纳米片阵列网络 NiCo2O4/MnO2,作为 LOB 的高效阴极催化剂材料。这种异质结构可以通过引发异质界面的界面扰动,加速电子传递并影响中间体吸附过程中的电荷转移过程,从而加速氧还原和氧进化动力学,调节产物分解,有望解决上述问题。该研究利用一种简单的方法,通过构建 Mott-Schottky 异质结构巧妙地调节了放电产物的形态,为设计旨在优化反应中间产物吸附的高效催化剂提供了重要参考。
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引用次数: 0
Design of AI-Enhanced and Hardware-Supported Multimodal E-Skin for Environmental Object Recognition and Wireless Toxic Gas Alarm 设计用于环境物体识别和无线有毒气体报警的人工智能增强型和硬件支持的多模态电子皮肤。
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2024-07-29 DOI: 10.1007/s40820-024-01466-6
Jianye Li, Hao Wang, Yibing Luo, Zijing Zhou, He Zhang, Huizhi Chen, Kai Tao, Chuan Liu, Lingxing Zeng, Fengwei Huo, Jin Wu

Highlights

  • A novel organohydrogel-based multimodal e-skin with excellent sensing performance for temperature, humidity, pressure, proximity, and NO2 is proposed for the first time, showing powerful sensing capabilities beyond natural skin.

  • The developed multimodal e-skin exhibited extraordinary sensing performance at room temperature, including fast pressure response time (0.2 s), high temperature sensitivity (9.38% °C-1), a wide range of humidity response (22%–98% RH), high NO2 sensitivity (254% ppm-1), a low detection limit (11.1 ppb NO2) and the abilities to sense the proximity of objects accurately, which are yet achieved by previous e-skins.

  • The multimodal e-skin was combined with the deep neural network algorithm and wireless alarm circuit to achieve zero-error classification of different objects and rapid response to NOx leak incidents, proving the feasibility of the e-skin-assisted rescue robot for post-earthquake rescue.

由于废墟结构不稳定和余震不断,震后救援任务充满挑战。目前的救援机器人大多缺乏与环境互动的能力,导致救援效率低下。此次提出的多模态电子皮肤(e-skin)不仅再现了自然皮肤的压力、温度和湿度感知能力,还开发了自然皮肤之外的感知功能--感知物体的接近程度和二氧化氮气体。基于 Ecoflex 和有机水凝胶的多层堆叠结构使电子皮肤具有与天然皮肤相似的机械性能。集成了多模态电子皮肤和人工智能(AI)算法的救援机器人具有很强的环境感知能力,能准确分辨物体并通过抓取识别人体肢体,为震后自动救援奠定了基础。此外,电子皮肤与二氧化氮无线报警电路的结合,使机器人能够实时感知环境中的有毒气体,从而采取相应措施保护被困人员免受有毒环境的伤害。由人工智能算法和硬件电路驱动的多模态电子皮肤具有强大的环境感知和信息处理能力,作为与物理世界交互的界面,极大地拓展了智能机器人的应用场景。
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引用次数: 0
Ultra-Stable Sodium-Ion Battery Enabled by All-Solid-State Ferroelectric-Engineered Composite Electrolytes 全固态铁电工程复合电解质带来的超稳定钠离子电池
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2024-07-25 DOI: 10.1007/s40820-024-01474-6
Yumei Wang, Zhongting Wang, Xiaoyu Xu, Sam Jin An Oh, Jianguo Sun, Feng Zheng, Xiao Lu, Chaohe Xu, Binggong Yan, Guangsheng Huang, Li Lu

Highlights

  • The capacity fading mechanism of the conventional Na3V2(PO4)3//Na3V2(PO4)3 (NVP//NVP) cell has been investigated.

  • All-solid-state ferroelectric-engineered composite electrolyte could improve the electrolyte–electrode interfacial stability as well as the interfacial ion conduction of the Na-ion battery using the NVP anode.

  • Outstanding cyclic stability has been achieved in the all-solid-state Na-ion battery using the NVP anode, with a capacity fading rate as low as 0.005% per cycle.

研究了传统 Na3V2(PO4)3//Na3V2(PO4)3(NVP//NVP)电池的容量衰减机制。全固态铁电工程复合电解质可以提高使用 NVP 负极的钠离子电池的电解质-电极界面稳定性以及界面离子传导性。使用 NVP 阳极的全固态钠离子电池实现了出色的循环稳定性,每循环容量衰减率低至 0.005%。
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引用次数: 0
Metal–Organic Framework-Based Photodetectors 基于金属有机框架的光电探测器
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2024-07-25 DOI: 10.1007/s40820-024-01465-7
Jin-Biao Zhang, Yi-Bo Tian, Zhi-Gang Gu, Jian Zhang

Highlights

  • The methods of preparing metal–organic framework (MOF)-based photodetectors and various types of MOFs are introduced.

  • The applications of MOF photodetectors in the detection of X-ray, ultraviolet, and infrared radiation, biosensing, and circularly polarized light detection are summarized.

  • Challenges in developing practical MOF photodetector and concepts to solve those critical challenges are discussed.

介绍了基于金属有机框架(MOF)的光检测器的制备方法和各种类型的 MOF,总结了 MOF 光检测器在 X 射线、紫外线和红外线辐射检测、生物传感和圆偏振光检测方面的应用,讨论了开发实用 MOF 光检测器所面临的挑战和解决这些关键挑战的概念。
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引用次数: 0
Interpenetrated Structures for Enhancing Ion Diffusion Kinetics in Electrochemical Energy Storage Devices 用于增强电化学储能设备中离子扩散动力学的互穿结构
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2024-07-25 DOI: 10.1007/s40820-024-01472-8
Xinzhe Xue, Longsheng Feng, Qiu Ren, Cassidy Tran, Samuel Eisenberg, Anica Pinongcos, Logan Valdovinos, Cathleen Hsieh, Tae Wook Heo, Marcus A. Worsley, Cheng Zhu, Yat Li

Highlights

  • A new and compact device configuration was created with two interpenetrated, individually addressable electrodes, allowing precise control over the geometric features and interactions between the electrodes.

  • The interpenetrated electrode design improves ion diffusion kinetics in electrochemical energy storage devices by shortening the ion diffusion length and reducing ion concentration inhomogeneity.

  • The device with interpenetrated electrodes outperformed the traditional separate electrode configuration, enhancing both volumetric energy density and capacity retention rate.

穿插电极设计通过缩短离子扩散长度和减少离子浓度不均匀性,改善了电化学储能装置中的离子扩散动力学。穿插电极装置的性能优于传统的独立电极配置,提高了体积能量密度和容量保持率。
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引用次数: 0
A Review of Anode Materials for Dual-Ion Batteries 双离子电池阳极材料综述。
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2024-07-24 DOI: 10.1007/s40820-024-01470-w
Hongzheng Wu, Shenghao Luo, Hubing Wang, Li Li, Yaobing Fang, Fan Zhang, Xuenong Gao, Zhengguo Zhang, Wenhui Yuan

Highlights

  • The development history and working mechanism of dual-ion batteries are reviewed, with an emphasis on the latest advancement in anode materials.

  • A comprehensive and detailed summary of the synthesis strategies, structural optimization, performance characterization, and reaction principles of four types of anode materials for dual-ion batteries is presented.

  • The current challenges of anode materials are highlighted, and the optimization strategies of advanced anode materials and battery systems are discussed, providing future research directions for the design of commercial dual-ion batteries.

有别于 "摇椅式 "锂离子电池(LIB),双离子电池(DIB)正极侧独特的阴离子插层化学反应赋予其低成本、高电压和生态友好的内在优势,受到广泛关注,有望实现下一代大规模储能应用。虽然 DIBs 阳极侧的电化学反应与 LIBs 相似,但实际上,为了配合阴极侧阴离子的快速插入动力学,并考虑与同时作为活性材料的电解质体系的兼容性,阳极材料起着非常重要的作用,迫切需要合理的结构设计和性能优化。对以往研究的回顾和总结将有助于未来对 DIB 的探索和优化。在此,我们总结了 DIBs 的发展过程和工作机理,并对 DIBs 阳极材料的最新研究及其在不同电池体系中的应用进行了详尽分类。此外,还简要讨论了阳极材料的结构设计、反应机理和电化学性能。最后,还提出了基本挑战、潜在策略和前景展望。希望这篇综述能为研究人员探索更优越的负极材料和先进系统提供一些启示,从而进一步推动 DIBs 的发展。
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引用次数: 0
Delivering Microrobots in the Musculoskeletal System 在肌肉骨骼系统中输送微型机器人。
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2024-07-22 DOI: 10.1007/s40820-024-01464-8
Mumin Cao, Renwang Sheng, Yimin Sun, Ying Cao, Hao Wang, Ming Zhang, Yunmeng Pu, Yucheng Gao, Yuanwei Zhang, Panpan Lu, Gaojun Teng, Qianqian Wang, Yunfeng Rui

Highlights

  • A systematic review of recent advances of microrobots applied in the musculoskeletal system with an emphasis on design strategies of microrobotic systems for tissue regeneration.

  • The fabrication, motion and control, and image-guided delivery of microrobots in the musculoskeletal system are reviewed based on the up-to-date works.

  • Prospects and challenges for future clinical translation of microrobots in the musculoskeletal system and regenerative medicine are discussed.

肌肉骨骼系统疾病是造成全球疾病负担的主要因素,而目前的治疗方法疗效有限。患者经常遭受慢性疼痛的折磨,最终可能不得不接受终末期手术。因此,未来的治疗应侧重于早期发现和干预区域病变。微型机器人具有智能、精确和微创靶向给药的优势,已逐渐应用于生物体内。通过与控制系统和成像系统的结合,具有良好生物安全性的微机器人可被输送到所需的区域进行治疗。在肌肉骨骼系统中,微机器人主要用于运送干细胞/药物或清除体内有害物质。与传统的生物材料和组织工程策略相比,主动运动提高了细胞/药物局部靶向的效率和穿透力。本综述讨论了微机器人系统在肌肉骨骼系统不同组织中的前沿应用。通过评估不同微型机器人的特点,我们总结了阻碍临床转化的挑战和障碍,最后指出了微型机器人在肌肉骨骼系统中的未来发展方向。
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引用次数: 0
Heterogeneous CuxO Nano-Skeletons from Waste Electronics for Enhanced Glucose Detection 从废弃电子产品中提取异质 CuxO 纳米微晶用于增强葡萄糖检测。
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2024-07-18 DOI: 10.1007/s40820-024-01467-5
Yexin Pan, Ruohan Yu, Yalong Jiang, Haosong Zhong, Qiaoyaxiao Yuan, Connie Kong Wai Lee, Rongliang Yang, Siyu Chen, Yi Chen, Wing Yan Poon, Mitch Guijun Li

Electronic waste (e-waste) and diabetes are global challenges to modern societies. However, solving these two challenges together has been challenging until now. Herein, we propose a laser-induced transfer method to fabricate portable glucose sensors by recycling copper from e-waste. We bring up a laser-induced full-automatic fabrication method for synthesizing continuous heterogeneous CuxO (h-CuxO) nano-skeletons electrode for glucose sensing, offering rapid (< 1 min), clean, air-compatible, and continuous fabrication, applicable to a wide range of Cu-containing substrates. Leveraging this approach, h-CuxO nano-skeletons, with an inner core predominantly composed of Cu2O with lower oxygen content, juxtaposed with an outer layer rich in amorphous CuxO (a-CuxO) with higher oxygen content, are derived from discarded printed circuit boards. When employed in glucose detection, the h-CuxO nano-skeletons undergo a structural evolution process, transitioning into rigid Cu2O@CuO nano-skeletons prompted by electrochemical activation. This transformation yields exceptional glucose-sensing performance (sensitivity: 9.893 mA mM−1 cm−2; detection limit: 0.34 μM), outperforming most previously reported glucose sensors. Density functional theory analysis elucidates that the heterogeneous structure facilitates gluconolactone desorption. This glucose detection device has also been downsized to optimize its scalability and portability for convenient integration into people’s everyday lives.

电子废物(e-waste)和糖尿病是现代社会面临的全球性挑战。然而,要同时解决这两个难题,至今仍是一项挑战。在此,我们提出了一种激光诱导转移方法,通过回收电子垃圾中的铜来制造便携式葡萄糖传感器。我们提出了一种激光诱导全自动合成用于葡萄糖传感的连续异质 CuxO(h-CuxO)纳米骨架电极的方法,该方法可从废弃的印刷电路板中快速(xO 纳米骨架的内核主要由含氧量较低的 Cu2O 组成,外层则富含含氧量较高的无定形 CuxO(a-CuxO)。在葡萄糖检测中使用时,h-CuxO 纳米骨架会经历一个结构演变过程,在电化学活化的作用下转变为坚硬的 Cu2O@CuO 纳米骨架。这种转变产生了卓越的葡萄糖传感性能(灵敏度:9.893 mA mM-1 cm-2;检测限:0.34 μM),优于之前报道的大多数葡萄糖传感器。密度泛函理论分析表明,异质结构有利于葡萄糖酸内酯的解吸。该葡萄糖检测装置还进行了缩小,以优化其可扩展性和便携性,方便融入人们的日常生活。
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引用次数: 0
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Nano-Micro Letters
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