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The mRNA-Based Innovative Strategy: Progress and Challenges. 基于mrna的创新策略:进展与挑战。
IF 36.3 1区 材料科学 Q1 Engineering Pub Date : 2026-01-15 DOI: 10.1007/s40820-025-01906-x
Huayuan Zhou, Dali Wei, Zhejie Chen, Hao Chen, Chuhuang Dong, Wei Yao, Jiawen Wang, Xueliang Liu, Yuqing Li, Yu Yang, Weihong Tan

As the central template for protein expression, messenger ribonucleic acid (mRNA) holds immense potential for novel therapeutic strategies. Over the past few decades, mRNA-based therapeutics have demonstrated remarkable efficacy in a range of applications, including epidemic vaccine, cancer vaccine, protein replacement therapy, cytokine therapy, cell therapy and gene editing. Due to the inherent instability of mRNA, the rational design of mRNA structure is the prerequisite for therapeutic utility while effective delivery systems are also essential for in vivo applications. This review focuses on the optimization of mRNA structure and highlights key delivery strategies. It also provides a comprehensive overview of the major applications of mRNA-based strategies. In addition, it highlights the persistent challenges in mRNA therapeutics, particularly in terms of stability, immunogenicity, delivery efficiency and safety. By examining recent advances in mRNA design, delivery and application, this review aims to support ongoing research and development in the field of mRNA-based therapeutics.

作为蛋白质表达的中心模板,信使核糖核酸(mRNA)在新的治疗策略方面具有巨大的潜力。在过去的几十年里,基于mrna的治疗方法在流行病疫苗、癌症疫苗、蛋白质替代疗法、细胞因子疗法、细胞疗法和基因编辑等一系列应用中显示出显著的疗效。由于mRNA固有的不稳定性,合理的mRNA结构设计是治疗效用的先决条件,而有效的递送系统对于体内应用也是必不可少的。本文综述了mRNA结构的优化和关键的递送策略。它还提供了基于mrna的策略的主要应用的全面概述。此外,它还强调了mRNA治疗方法的持续挑战,特别是在稳定性、免疫原性、递送效率和安全性方面。通过研究mRNA设计、传递和应用的最新进展,本综述旨在支持基于mRNA的治疗领域正在进行的研究和开发。
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引用次数: 0
Mechano-Electrochemical Synergy in Cellulose@MOF Scaffold-Based Asymmetric Electrolyte for Stable Solid-State Lithium Metal Batteries 稳定固态锂金属电池中Cellulose@MOF支架基不对称电解质的机械-电化学协同作用
IF 36.3 1区 材料科学 Q1 Engineering Pub Date : 2026-01-15 DOI: 10.1007/s40820-025-02039-x
Wanqing Fan, Xuetao Shi, Ying Huang, Kaihang She, Bowei Song, Zheng Zhang

Highlights

  • A structurally simple asymmetric solid-state electrolyte successfully stabilizes the interface between lithium metal and high-voltage cathodes in solid-state lithium metal batteries.

  • Environmentally friendly cellulose provides high mechanical support, while layered self-assembled metal–organic frameworks restrict TFSI⁻, efficiently promoting Li⁺ transport.

  • The assembled pouch cell exhibited a high gravimetric/volume energy density of 337.9 Wh kg−1/711.7 Wh L−1.

一种结构简单的非对称固态电解质成功地稳定了固态锂金属电池中锂金属与高压阴极之间的界面。环保的纤维素提供了高的机械支撑,而层状自组装的金属有机框架限制了TFSI⁻,有效地促进了Li⁺的传输。组装后的袋状电池具有较高的重量/体积能量密度,为337.9 Wh kg−1/711.7 Wh L−1。
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引用次数: 0
Creation of an Artificial Layer for Boosting Zn2+ Mass Transfer and Anode Stability in Aqueous Zinc Metal Batteries 用于提高锌金属水电池中Zn2+传质和阳极稳定性的人工层的创建
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2026-01-15 DOI: 10.1007/s40820-025-01973-0
Mingcong Tang, Qun Liu, Gang Liu, Xiaohong Zou, Kouer Zhang, Zhenlu Yu, Biao Zhang, Liang An
  • Natural extract, curcumin, was employed as the protective layer to improve the zinc anode stability.

  • The curcumin-based layer balanced the efficient thickness, robust adhesion, and facilitated Zn2+ transportation.

  • The desolvation mechanism with a metal ion chelating agent aside was clearly elucidated.

采用天然提取物姜黄素作为保护层,提高锌阳极的稳定性。姜黄素基层的有效厚度平衡,附着力强,有利于Zn2+的运输。明确了除金属离子螯合剂外的脱溶机理。
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引用次数: 0
Key Advancements and Emerging Trends of Perovskite Solar Cells in 2024–2025 2024-2025年钙钛矿太阳能电池的关键进展和新兴趋势
IF 36.3 1区 材料科学 Q1 Engineering Pub Date : 2026-01-15 DOI: 10.1007/s40820-025-02022-6
Xiangqian Shen, Xuesong Lin, Hongzhen Su, Ziyang Zhang, Tianhao Wu, Jing Zhang, Yong Peng, Yiqiang Zhang, Shufang Zhang, Zhongmin Zhou, Xiangyue Meng, Peng Gao, Wei Chen, Yongzhen Wu, Chuanjiang Qin, Qifeng Han, Yanbo Wang, Liyuan Han

The past two years have witnessed remarkable progress in perovskite solar cells (PSCs), marked by breakthroughs in power conversion efficiency and strides in addressing long-term operational stability. At present, the certified power conversion efficiencies of single-junction PSCs and silicon/perovskite tandem cells have surpassed 27% and 34%, respectively. Regarding stability, researchers begun to focus their attention on the challenges faced by PSCs when operated in outdoor environments. Furthermore, breakthroughs in the utilization of green solvents, fabrication in ambient air conditions, aqueous-phase synthesis of perovskite raw materials at kilogram scale, vacuum flash evaporation, and machine learning-assisted design are accelerating the commercialization of PSCs. The review summarizes the key advancements of PSCs during 2024–2025. It identifies a critical performance discrepancy between small-area devices and perovskite solar modules and delves into strategies aimed at bridging this gap. Finally, perspectives on the future directions of PSCs are presented, with a particular emphasis on improving photocurrent and environmental sustainability.

在过去的两年里,钙钛矿太阳能电池(PSCs)取得了显著的进展,在功率转换效率方面取得了突破,在解决长期运行稳定性方面取得了长足的进步。目前,单结PSCs和硅/钙钛矿串联电池的认证功率转换效率分别超过27%和34%。在稳定性方面,研究人员开始关注psc在室外环境下运行时所面临的挑战。此外,绿色溶剂的利用、环境空气条件下的制造、钙钛矿原料在公斤级的水相合成、真空闪蒸和机器学习辅助设计等方面的突破正在加速psc的商业化。综述总结了2024-2025年PSCs的主要进展。它确定了小面积器件和钙钛矿太阳能模块之间的关键性能差异,并深入研究了旨在弥合这一差距的策略。最后,对PSCs的未来发展方向进行了展望,特别强调了改善光电流和环境可持续性。
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引用次数: 0
Construction of Modifiable Phthalocyanine-Based Covalent Organic Frameworks with Irreversible Linking for Efficient Photocatalytic CO2 Reduction 基于不可逆连接的可修饰酞菁共价有机框架的构建及其光催化CO2的高效还原
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2026-01-15 DOI: 10.1007/s40820-025-01967-y
Xuefei Zhou, Shaowei Yang, Zhengyang Hu, Zhanwei Chen, Ying Guo, Tianshuai Wang, Qiuyu Zhang, Hepeng Zhang
Covalent organic frameworks (COFs) are considered promising catalysts for photocatalytic CO 2 reduction reaction (pCO 2 RR) due to facilitated regulations. However, the instability of COFs with dynamic reversible covalent bonds and the limited modifiability of COFs with irreversible covalent bonds restricted the enhancement of the pCO 2 RR performance. Herein, three phthalocyanine-based COFs with ether-linked, CoOP, CoPOP, and CoBOP, were successfully prepared via in situ polycondensation using modifiable bis-phthalonitrile. CoBOP achieved a record of syngas performance in pCO 2 RR systems with photosensitizers and sacrificial agents (CO 83.7 mmol g −1 h −1 and H 2 54.7 mmol g −1 h −1 ), surpassing most COF photocatalysts. Additionally, CoOP, CoPOP, and CoBOP exhibit stabilities in extreme environments owing to their irreversible covalent bonds. Experimental and density functional theory analyses confirm that the optimally matched the lowest unoccupied molecular orbital of the linking unit between the photosensitizer and active unit endowed CoBOP with the highest photoelectron transfer efficiency among the three catalysts, boosting its pCO 2 RR activity. This work is highly instructive for designing COFs with structure-adjustable and irreversible covalent bonds.
共价有机框架(COFs)因其易于调控而被认为是光催化co2还原反应(pco_2 RR)中很有前途的催化剂。然而,具有动态可逆共价键的COFs的不稳定性和具有不可逆共价键的COFs的有限可改性性限制了pco_2 RR性能的提高。本文以改性双邻苯二腈为原料,通过原位缩聚法制备了三种以醚连接的酞菁基COFs,分别为CoOP、CoPOP和CoBOP。CoBOP在具有光敏剂和牺牲剂(CO 83.7 mmol g−1 h−1和h2 54.7 mmol g−1 h−1)的pco_2 RR体系中取得了创纪录的合成气性能,超过了大多数COF光催化剂。此外,CoOP、CoPOP和CoBOP由于其不可逆的共价键在极端环境中表现出稳定性。实验和密度功能理论分析证实,光敏剂与活性单元之间的最低未占据分子轨道最优匹配使CoBOP具有最高的光电子传递效率,提高了CoBOP的pco2 RR活性。这对设计具有结构可调和不可逆共价键的COFs具有重要的指导意义。
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引用次数: 0
High-Efficiency Perovskite/Silicon Tandem Solar Cells Based on Wide-Bandgap Perovskite Solar Cells with Unprecedented Fill Factor. 基于具有空前填充系数的宽禁带钙钛矿太阳能电池的高效钙钛矿/硅串联太阳能电池。
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2026-01-14 DOI: 10.1007/s40820-025-01959-y
Li-Chun Chang,The Duong,Viqar Ahmad,Hualin Zhan,Anh Dinh Bui,Jana-Isabelle Polzin,Armin Richter,Gabriel Bartholazzi,Keqing Huang,Zhongshu Yang,Wei Wang,Yihui Hou,Li Li,Qian Cui,Rabin Basnet,Jianfei Yang,Hong Lin,Guozheng Du,Khoa Nguyen,Dang-Thuan Nguyen,Lachlan E Black,Daniel MacDonald,Daniel Walter,Klaus J Weber,Kylie R Catchpole,Heping Shen
Recent progress in inverted perovskite solar cells (iPSCs) highlights the critical role of interface engineering between the charge transport layer and perovskite. Self-assembled monolayers (SAM) on transparent conductive oxide electrodes serve effectively as hole transport layers, though challenges such as energy mismatches and surface inhomogeneities remain. Here, a blended self-assembled monolayer of (2-(9H-carbazol-9-yl)ethyl)phosphonic acid (2PACz) and (4-(3,6-Dimethyl-9H-carbazol-9-yl)butyl)phosphonic acid (Me-4PACz) is developed, offering improved surface potential uniformity and interfacial energy alignment compared to individual SAMs. Interactions between the SAMs and ionic species are investigated with simulation analysis conducted, revealing the elimination of interfacial energy barriers through precise energy-level tuning. This strategy enables wide-bandgap (1.67 eV) perovskite solar cells with inverted structures with over 24% efficiency, an open-circuit voltage (Voc) of 1.268 V, and a certified fill factor (FF) of 86.8%, leading to a certified efficiency of 23.42%. The approach also enables high-efficiency semi-transparent devices and a mechanically stacked four-terminal perovskite/silicon tandem solar cell reaching 30.97% efficiency.
近年来倒置钙钛矿太阳能电池(iPSCs)的研究进展突出了电荷传输层与钙钛矿之间界面工程的关键作用。透明导电氧化物电极上的自组装单层(SAM)可以有效地作为空穴传输层,尽管存在能量不匹配和表面不均匀性等挑战。在这里,(2-(9h -咔唑-9-基)乙基)膦酸(2PACz)和(4-(3,6-二甲基- 9h -咔唑-9-基)丁基)膦酸(Me-4PACz)的混合自组装单层被开发出来,与单个sam相比,提供了更好的表面电位均匀性和界面能排列。通过模拟分析研究了SAMs与离子之间的相互作用,揭示了通过精确的能级调谐消除界面能垒。该策略使具有倒置结构的宽带隙(1.67 eV)钙钛矿太阳能电池的效率超过24%,开路电压(Voc)为1.268 V,认证填充因子(FF)为86.8%,从而获得23.42%的认证效率。该方法还实现了高效半透明器件和机械堆叠的四端钙钛矿/硅串联太阳能电池,效率达到30.97%。
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引用次数: 0
Dopant-Free Ultra-Thin Spiro-OMeTAD Enables Near 30%-Efficient n-i-p Perovskite/Silicon Tandem Solar Cells. 无掺杂超薄Spiro-OMeTAD实现近30%效率的n-i-p钙钛矿/硅串联太阳能电池。
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2026-01-14 DOI: 10.1007/s40820-025-01962-3
Xiangying Xue,Weichuang Yang,Zhiqin Ying,Fangfang Cao,Yuheng Zeng,Zhenhai Yang,Xi Yang,Jichun Ye
A major challenge for n-i-p structured perovskite/silicon tandem solar cells (TSCs) is the use of 2,2',7,7'-tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9'-spirobifluorene (spiro-OMeTAD), a commonly used hole transport layer, which induces significant optical losses and consequently reduces device current. Herein, we propose an ultra-thin (10 nm) vacuum thermal evaporation (VTE)-deposited spiro-OMeTAD, coupled with a 2D/3D perovskite heterojunction, to simultaneously enhance the optical and electrical properties of n-i-p perovskite/silicon TSCs. Our results demonstrate that the 10-nm-thick spiro-OMeTAD layer significantly improves optical performance, achieving a 92.2% reduction in parasitic absorption and an 18.4% decrease in reflection losses. Additionally, the incorporation of the 2D/3D perovskite heterojunction facilitates improved molecular arrangement and enhanced surface uniformity of the ultrathin spiro-OMeTAD, leading to higher tolerance to interface defects and more efficient hole extraction. Consequently, n-i-p perovskite/silicon TSCs featuring ultrathin spiro-OMeTAD exhibit remarkable efficiencies of 29.73% (0.135 cm2) and 28.77% (28.25% certified efficiency, 1.012 cm2), along with improved stability.
N- i-p结构钙钛矿/硅串联太阳能电池(tsc)的一个主要挑战是使用2,2',7,7'-四基[N,N-二(4-甲氧基苯基)氨基]-9,9'-螺双芴(spiro-OMeTAD),一种常用的空穴传输层,它会引起显著的光学损耗,从而降低器件电流。在此,我们提出了超薄(10 nm)真空热蒸发(VTE)沉积的spiro-OMeTAD,加上2D/3D钙钛矿异质结,以同时提高n-i-p钙钛矿/硅tsc的光学和电学性能。我们的研究结果表明,10nm厚的spiro-OMeTAD层显着提高了光学性能,实现了92.2%的寄生吸收减少和18.4%的反射损失减少。此外,2D/3D钙钛矿异质结的掺入有助于改善分子排列,增强超薄spiro-OMeTAD的表面均匀性,从而提高了对界面缺陷的耐受性,提高了空穴提取效率。因此,具有超薄spiro-OMeTAD的n-i-p钙钛矿/硅tsc的效率分别为29.73% (0.135 cm2)和28.77%(28.25%认证效率,1.012 cm2),稳定性也有所提高。
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引用次数: 0
Recycling of High-Purity Lithium Metal from Waste Battery by Photoelectrochemical Extraction at Ultralow Overall Potential. 超低总电位下光电萃取法回收废电池中高纯金属锂。
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2026-01-14 DOI: 10.1007/s40820-025-01958-z
Longfei Yang,Chao Huang,Yanhong Lyu,Dawei Chen,Aibin Huang,Jianyun Zheng
To ease the scarcity of lithium (Li) resource and cut down on environmental pollution, an efficient, selective, inexpensive and sustainable Li recycling process from waste batteries is needed, which is yet to be achieved. Here, we report a low-potential photoelectrochemical (PEC) system that selectively and efficiently extracts Li metals from multi-cation electrolytes under 1 sun illumination. Based on the difference of redox potential, we can get rid of the disturbance of other cations (i.e., Fe, Co and Ni ions) by a bias-free PEC device to realize the extraction of high-purity Li metals on a coplanar Si-based photocathode-TiO2 photoanode tandem device at 2 V of applied bias (far less than the redox potentials of Li+/Li). In such system, the extraction rate of Li metals (purity > 99.5%) exceeds 1.35 g h-1 m-2 with 90% of Faradaic efficiency. Long-term experiments, different electrode/electrolyte tests, and various price assessments further demonstrate the stability, compatibility and economy of PEC extraction system, enabling a solar-driven pathway for the recycling of critical metal resources.
为了缓解锂资源的短缺和减少环境污染,需要一种高效、有选择性、廉价和可持续的废电池锂回收工艺,但目前尚未实现。在这里,我们报道了一种低电位光电化学(PEC)系统,该系统在1个太阳光照下选择性和有效地从多阳离子电解质中提取锂金属。基于氧化还原电位的差异,我们可以通过无偏置PEC装置消除其他阳离子(即Fe、Co和Ni离子)的干扰,在2 V的外加偏置(远小于Li+/Li的氧化还原电位)下,在共面si基光电阴极- tio2光阳极串联装置上实现高纯Li金属的萃取。在该体系中,Li金属(纯度> 99.5%)的提取率超过1.35 g h-1 m-2,法拉第效率达到90%。长期实验、不同电极/电解质测试和各种价格评估进一步证明了PEC提取系统的稳定性、兼容性和经济性,为关键金属资源的回收提供了太阳能驱动的途径。
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引用次数: 0
A Multi-Scale Cross-Band Defense System Integrating Decoupled Visible, Dynamic Infrared Camouflage and Electromagnetic Shielding 集解耦可见、动态红外伪装和电磁屏蔽于一体的多尺度跨波段防御系统
IF 26.6 1区 材料科学 Q1 Engineering Pub Date : 2026-01-13 DOI: 10.1007/s40820-025-01961-4
Junlin Liu, Shujuan Tan, Xinrui Yang, Jiajie Zhu, Xin Yan, Tianyu Chen, Guangbin Ji
  • A multi-scale cross-band military lightweight camouflage system is constructed via elaborate hierarchical structure design.

  • This system can achieve rich color presentation to meet the visible camouflage requirements in different backgrounds.

  • This system can simultaneously achieve an infrared emissivity modulation of Δε > 0.5, achieving excellent dynamic infrared stealth.

  • This system characterized by its light weight can also achieve efficient electromagnetic interference shielding and excellent electrothermal conversion.

通过精细的分层结构设计,构建了多尺度跨波段军用轻型迷彩系统。该系统可以实现丰富的色彩呈现,满足不同背景下的可见伪装要求。该系统可同时实现Δε >; 0.5的红外发射率调制,实现优异的动态红外隐身。该系统还具有重量轻的特点,可以实现高效的电磁干扰屏蔽和优良的电热转换。
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引用次数: 0
Stabilizing the Anode and Cathode Interface Synchronously via Electrolyte-Triggered Hydrogel Interphase for Zinc Metal Batteries 通过电解触发水凝胶界面同步稳定锌金属电池的阳极和阴极界面
IF 36.3 1区 材料科学 Q1 Engineering Pub Date : 2026-01-13 DOI: 10.1007/s40820-025-02051-1
Xinze Cai, Xin Li, Jiahui Liang, Jiazhen Qiu, Wenkuo Lin, Chunlong Dai, Zifeng Lin, Jiangqi Zhao

Highlights

  • Decipher the multi-scale causes of interfacial instability in aqueous electrolyte systems via numerical simulations.

  • Develop an electrolyte-triggered interphase construction strategy to achieve synergistic regulation of both the anode and cathode.

  • Achieve high Coulombic efficiency (99.5%) and long-term cycling stability (over 6000 h) at ultra-low current density (0.1 mA cm−2) in zinc metal batteries.

通过数值模拟破译水电解质系统界面不稳定性的多尺度原因。开发一种电解质触发的间相构建策略,以实现阳极和阴极的协同调节。锌金属电池在超低电流密度(0.1 mA cm−2)下实现高库仑效率(99.5%)和长期循环稳定性(超过6000 h)。
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引用次数: 0
期刊
Nano-Micro Letters
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