Pub Date : 2025-12-04DOI: 10.1016/j.ad.2025.104516
M. Castillo Gutiérrez, B. Van Ingen Arteaga
{"title":"RF-Trichophyton indotineae: A New Diagnostic and Therapeutic Challenge","authors":"M. Castillo Gutiérrez, B. Van Ingen Arteaga","doi":"10.1016/j.ad.2025.104516","DOIUrl":"10.1016/j.ad.2025.104516","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 2","pages":"Article 104516"},"PeriodicalIF":2.8,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-04DOI: 10.1016/j.ad.2025.104518
E. Carmona-Rocha , J. De Diego-Adeliño , M.J. Tribó , L. Puig
In the routine clinical practice in dermatology, there is a high burden of psychiatric morbidity due to primary psychiatric disorders that secondarily affect the skin or dermatological disorders that secondarily can have a profound psychosocial and mental health impact. We present a narrative review on the use of psychotropic drugs, with the aim of addressing the intersection between mental health and dermatology. The article aims to be a practical guide, providing clear and concise recommendations on the indications, dosing, adverse effects, special considerations, or contraindications of the most widely used drugs today, with the goal of providing dermatologists with the basic tools for the appropriate global therapeutic management of these patients.
{"title":"Psychotropic Drugs: A Practical Guide for Use in Dermatology","authors":"E. Carmona-Rocha , J. De Diego-Adeliño , M.J. Tribó , L. Puig","doi":"10.1016/j.ad.2025.104518","DOIUrl":"10.1016/j.ad.2025.104518","url":null,"abstract":"<div><div>In the routine clinical practice in dermatology, there is a high burden of psychiatric morbidity due to primary psychiatric disorders that secondarily affect the skin or dermatological disorders that secondarily can have a profound psychosocial and mental health impact. We present a narrative review on the use of psychotropic drugs, with the aim of addressing the intersection between mental health and dermatology. The article aims to be a practical guide, providing clear and concise recommendations on the indications, dosing, adverse effects, special considerations, or contraindications of the most widely used drugs today, with the goal of providing dermatologists with the basic tools for the appropriate global therapeutic management of these patients.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 2","pages":"Article 104518"},"PeriodicalIF":2.8,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-04DOI: 10.1016/j.ad.2025.104521
A. Bennassar Vicens
{"title":"Semi-Buried Dermogaleal Subcutaneous Suture: How to Keep Tension Away From the Wound","authors":"A. Bennassar Vicens","doi":"10.1016/j.ad.2025.104521","DOIUrl":"10.1016/j.ad.2025.104521","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 2","pages":"Article 104521"},"PeriodicalIF":2.8,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-04DOI: 10.1016/j.ad.2025.104512
M. Mansilla-Polo , D. Martín-Torregrosa , M. Saro-Buendía , B. Escutia-Muñoz , R. Botella-Estrada
{"title":"Identification of a Novel Heterozygous Variant c.497g>a (p.gly166glu) in Exon 5 of the Sting1 Gene as the Causative Factor of Sting-Associated Vasculopathy With Onset in Infancy (SAVI): A Case Report","authors":"M. Mansilla-Polo , D. Martín-Torregrosa , M. Saro-Buendía , B. Escutia-Muñoz , R. Botella-Estrada","doi":"10.1016/j.ad.2025.104512","DOIUrl":"10.1016/j.ad.2025.104512","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 2","pages":"Article 104512"},"PeriodicalIF":2.8,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-04DOI: 10.1016/j.ad.2025.104508
C. Fernández Romero , L. Vila Cobreros , P. Navarro Conde , E. Gimeno Carpio
{"title":"Treatment of Basosquamous Carcinoma With Sonidegib in a Patient with HIV","authors":"C. Fernández Romero , L. Vila Cobreros , P. Navarro Conde , E. Gimeno Carpio","doi":"10.1016/j.ad.2025.104508","DOIUrl":"10.1016/j.ad.2025.104508","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 2","pages":"Article 104508"},"PeriodicalIF":2.8,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-04DOI: 10.1016/j.ad.2025.104519
R. Moro , F. Mayo-Martínez , Z. García-Casado , M. Aguerralde-Martin , Victor Traves , E. Manrique-Silva , C. Requena , D.E. Elder , E. Nagore
Background and aims
The new WHO classification distinguishes two main pathogenic pathways for cutaneous melanoma, low and high-chronic sun damage (CSD). However, there are no studies to support its validity in the category of non-acral cutaneous lentiginous melanoma (NACLM). Thus, the aim of this study was to correlate the degree of solar elastosis (SE) with a range of clinicopathologic and genomic parameters in a cohort of NACLMs.
Material and methods
We conducted a retrospective cohort study of patients affected by an in situ or invasive NACLM distributed across three groups depending on the grade of SE. NACLM includes lentigo maligna melanoma and lentigo maligna, and other non-acral cutaneous lesions with a lentiginous growth pattern.
Results
The study included a total of 257 patients, 132 men (51.4%) and 125 women (48.6%) with a median age of 71 years. SE grade I was reported in 38 cases (14.8%), grade II in 61 cases (23.7%), and grade III in 158 cases (61.5%). Higher SE grade was related to head/neck location, older age at diagnosis and presence of lentigines in melanoma area. Lower SE grade was related to other locations, higher nevi count, presence of regression and BRAF V600E mutation (univariate logistic regression quantification: V600E vs WT; OR, 0.23; 95%CI, 0.05–1.06; p = 0.059).
Conclusion
SE grade is useful to classify NACLMs in different groups distinguished by their clinical, pathological, and molecular features. These results endorse the new WHO classification of low- and high-CSD melanomas. Moreover, they highlight the importance of reporting the grade of SE in the pathological report.
背景和目的：世卫组织的新分类区分了皮肤黑色素瘤的两种主要致病途径：低慢性和高慢性太阳损伤（CSD）。然而，尚无研究支持其在非肢端皮肤黄斑性黑色素瘤（NACLM）类别中的有效性。因此，本研究的目的是在NACLMs队列中将太阳弹性弹性（SE）的程度与一系列临床病理和基因组参数相关联。材料和方法：我们对原位或侵袭性NACLM患者进行了回顾性队列研究，根据SE的等级分为3组。NACLM包括恶性小晶状体黑色素瘤和恶性小晶状体，以及其他具有小晶状体生长模式的非肢端皮肤病变。结果：共纳入257例患者，其中男性132例（51.4%），女性125例（48.6%），中位年龄71岁。SE I级38例（14.8%），SE II级61例（23.7%），SE III级158例（61.5%）。SE等级越高，与头颈部位置、诊断时年龄越大以及黑素瘤区域存在小体有关。低SE等级与其他部位、高nevi计数、存在回归和BRAF V600E突变相关（单变量logistic回归量化：V600E vs WT； OR, 0.23; 95%CI, 0.05-1.06; p = 0.059）。结论：SE分级可以根据不同的临床、病理和分子特征对不同的NACLMs进行分类。这些结果支持世界卫生组织对低csd和高csd黑色素瘤的新分类。此外，他们还强调了在病理报告中报告SE分级的重要性。
{"title":"Comparison of Nonacral Cutaneous Lentiginous Melanomas According to the Degree of Solar Elastosis: Support for the New World Health Organization Classification","authors":"R. Moro , F. Mayo-Martínez , Z. García-Casado , M. Aguerralde-Martin , Victor Traves , E. Manrique-Silva , C. Requena , D.E. Elder , E. Nagore","doi":"10.1016/j.ad.2025.104519","DOIUrl":"10.1016/j.ad.2025.104519","url":null,"abstract":"<div><h3>Background and aims</h3><div>The new WHO classification distinguishes two main pathogenic pathways for cutaneous melanoma, low and high-chronic sun damage (CSD). However, there are no studies to support its validity in the category of non-acral cutaneous lentiginous melanoma (NACLM). Thus, the aim of this study was to correlate the degree of solar elastosis (SE) with a range of clinicopathologic and genomic parameters in a cohort of NACLMs.</div></div><div><h3>Material and methods</h3><div>We conducted a retrospective cohort study of patients affected by an in situ or invasive NACLM distributed across three groups depending on the grade of SE. NACLM includes lentigo maligna melanoma and lentigo maligna, and other non-acral cutaneous lesions with a lentiginous growth pattern.</div></div><div><h3>Results</h3><div>The study included a total of 257 patients, 132 men (51.4%) and 125 women (48.6%) with a median age of 71 years. SE grade I was reported in 38 cases (14.8%), grade II in 61 cases (23.7%), and grade III in 158 cases (61.5%). Higher SE grade was related to head/neck location, older age at diagnosis and presence of lentigines in melanoma area. Lower SE grade was related to other locations, higher nevi count, presence of regression and BRAF V600E mutation (univariate logistic regression quantification: V600E vs WT; OR, 0.23; 95%CI, 0.05–1.06; <em>p</em> <!-->=<!--> <!-->0.059).</div></div><div><h3>Conclusion</h3><div>SE grade is useful to classify NACLMs in different groups distinguished by their clinical, pathological, and molecular features. These results endorse the new WHO classification of low- and high-CSD melanomas. Moreover, they highlight the importance of reporting the grade of SE in the pathological report.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 2","pages":"Article 104519"},"PeriodicalIF":2.8,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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