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Actas dermo-sifiliograficas最新文献

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Prognostic Differences in Melanoma Between Patients With Locoregional Disease at Initial Diagnosis and Those Who Develop Locoregional Disease After Progression During Follow-Up 黑色素瘤的预后差异在最初诊断为局部疾病的患者和在随访期间进展为局部疾病的患者之间。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-04 DOI: 10.1016/j.ad.2025.104517
A. Luna , A. Alkhawaja , D. Rizo , C. Carrera , J. Malvehy , S. Puig , S. Podlipnik

Background and aims

Stage III cutaneous melanoma affects a heterogeneous group of patients. AJCC staging subdivides stage III according to micro- or macroscopic lymph nodes or in transit/cutaneous locoregional metastasis, without accounting for whether locoregional involvement is identified at diagnosis or post-progression. Information on potential divergent behavior among these subgroups is lacking.
The aim of the study is to analyze the differences in survival of melanoma patients with stages IIIB–IIID at diagnosis vs stages IIIB–IIID after relapse.

Materials and method

We conducted a cohort study with patients diagnosed with cutaneous melanoma between 1998 and 2022. Patients in stage III (AJCC 8th) were identified and divided into 2 cohorts: initial stages IIIB-D (iSIII) and stages IIIB-D during progression (pSIII). We analyzed the clinical and histopathological characteristics and performed Cox regression analysis for melanoma specific survival (MSS) and overall survival (OS).

Results

Of the 939 patients included, 608 had incident stage III (iSIII) melanoma and 331 had progressive stage III (pSIII) melanoma. Primary melanomas in the iSIII cohort showed greater Breslow thickness and higher mitotic indices and were more frequently ulcerated than those in the pSIII group (p < .001). Multivariable Cox regression analysis showed a slightly worse MSS and OS for patients in the pSIII cohort with an HR of 1.32 (95%CI, 1.05–1.66; p = 0.017) and an HR of 1.40 (95%CI, 1.14–1.72; p = 0.001) respectively.

Conclusions

Although patients from the pSIII cohort initially exhibited primary tumors with fewer aggressive features than primary tumors of the iSIII, after progression to stage III they showed a slightly worse MSS and OS than the iSIII cohort.
背景和目的：III期皮肤黑色素瘤影响异质组患者。AJCC分期根据微观或宏观淋巴结或运输/皮肤局部转移来细分III期，而不考虑是否在诊断时或进展后确定局部受病灶。关于这些亚群体之间潜在的分化行为的信息是缺乏的。本研究的目的是分析诊断时IIIB-IIID期黑色素瘤患者与复发后IIIB-IIID期患者的生存差异。材料和方法：我们对1998年至2022年间诊断为皮肤黑色素瘤的患者进行了一项队列研究。III期患者（AJCC第8期）被确定并分为2组：初始IIIB-D期（iSIII）和进展期IIIB-D期（pSIII）。我们分析了临床和组织病理学特征，并对黑色素瘤特异性生存期（MSS）和总生存期（OS）进行了Cox回归分析。结果：在纳入的939例患者中，608例为偶发III期（iSIII）黑色素瘤，331例为进行性III期（pSIII）黑色素瘤。与pSIII组相比，iSIII组原发性黑色素瘤的brreslow厚度和有丝分裂指数更高，溃疡发生率更高（P < 0.001）。多变量Cox回归分析显示，pSIII队列患者的MSS和OS稍差，HR分别为1.32 （95%CI, 1.05-1.66, p = 0.017）和1.40 （95%CI, 1.14-1.72, p = 0.001）。结论：尽管来自pSIII队列的患者最初表现出的原发肿瘤的侵袭性特征少于iSIII的原发肿瘤，但在进展到III期后，他们的MSS和OS比iSIII队列略差。
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引用次数: 0
Flushing in Carcinoid Syndrome 类癌综合征的潮红。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-04 DOI: 10.1016/j.ad.2025.104515
Á. Fernández Camporro, L. Palacio Aller
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引用次数: 0
Seborrheic Keratosis-like Pigmented Condylomata Acuminata: A Study of 62 Cases 脂溢性角化样色素性尖锐湿疣62例分析。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-04 DOI: 10.1016/j.ad.2025.104520
R. Corbalán-Vélez , D. López-Martínez , J.A. Ruiz-Maciá , A. Moreno-Docón , J. Román Gómez
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引用次数: 0
Co-occurrence of Dowling-Degos Disease and Hidradenitis Suppurativa: An Exploratory Study Dowling-Degos病与化脓性汗腺炎共发的探索性研究。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-04 DOI: 10.1016/j.ad.2025.104507
P. Garbayo-Salmons , J.C. Pascual , V. Exposito-Serrano , E. Agut-Busquet , A. Martorell , J. Romaní de Gabriel
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引用次数: 0
RF-Trichophyton indotineae: A New Diagnostic and Therapeutic Challenge 吲哚毛癣：一个新的诊断和治疗挑战。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-04 DOI: 10.1016/j.ad.2025.104516
M. Castillo Gutiérrez, B. Van Ingen Arteaga
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引用次数: 0
Psychotropic Drugs: A Practical Guide for Use in Dermatology 精神药物：皮肤病学实用指南。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-04 DOI: 10.1016/j.ad.2025.104518
E. Carmona-Rocha , J. De Diego-Adeliño , M.J. Tribó , L. Puig
In the routine clinical practice in dermatology, there is a high burden of psychiatric morbidity due to primary psychiatric disorders that secondarily affect the skin or dermatological disorders that secondarily can have a profound psychosocial and mental health impact. We present a narrative review on the use of psychotropic drugs, with the aim of addressing the intersection between mental health and dermatology. The article aims to be a practical guide, providing clear and concise recommendations on the indications, dosing, adverse effects, special considerations, or contraindications of the most widely used drugs today, with the goal of providing dermatologists with the basic tools for the appropriate global therapeutic management of these patients.
在皮肤科的常规临床实践中，由于继发影响皮肤的原发性精神疾病或继发影响社会心理和精神健康的皮肤病，精神疾病发病率的负担很高。我们提出了一个叙述性的审查使用精神药物，以解决精神健康和皮肤病学之间的交集的目的。本文旨在成为一个实用指南，就当今最广泛使用的药物的适应症、剂量、不良反应、特殊注意事项或禁忌症提供清晰简明的建议，目的是为皮肤科医生提供适当的全球治疗管理这些患者的基本工具。
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引用次数: 0
Bariatric Stamp 减肥邮票。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-04 DOI: 10.1016/j.ad.2025.104511
L. Taboada Paz, E. Vicente Basanta, M.M. Otero Rivas
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引用次数: 0
Progressive Verrucous Plaques of the Face 面部的渐进性疣状斑块。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-04 DOI: 10.1016/j.ad.2025.104509
L. Becker Micheletto , M. Ceolin Vione , J. Peruzzo
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引用次数: 0
Semi-Buried Dermogaleal Subcutaneous Suture: How to Keep Tension Away From the Wound 真皮半埋式皮下缝合：如何使张力远离伤口。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-04 DOI: 10.1016/j.ad.2025.104521
A. Bennassar Vicens
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引用次数: 0
Identification of a Novel Heterozygous Variant c.497g>a (p.gly166glu) in Exon 5 of the Sting1 Gene as the Causative Factor of Sting-Associated Vasculopathy With Onset in Infancy (SAVI): A Case Report 鉴定sting基因5外显子c.497g>a （p.gly166glu）是婴儿期发病的蜇伤相关血管病变（SAVI）的致病因素：一个病例报告。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-04 DOI: 10.1016/j.ad.2025.104512
M. Mansilla-Polo , D. Martín-Torregrosa , M. Saro-Buendía , B. Escutia-Muñoz , R. Botella-Estrada
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引用次数: 0
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