首页 > 最新文献

Alcohol (Hanover, York County, Pa.)最新文献

英文 中文
Articles of Public Interest 公益文章
Pub Date : 2024-05-06 DOI: 10.1111/acer.15343

When drinking choices are perceived as “just one drink,” with each single drink representing relatively slight risk, it may ironically lead to heavier drinking and alcohol-related harms. That's the finding of a novel study exploring the decision-making process around binge drinking. A better understanding of how people think about heavy episodic drinking could inform prevention and intervention approaches and help reduce the serious negative consequences of alcohol use. Young adults are especially vulnerable to high-risk drinking and its consequences; 29% are recent binge drinkers, and 15% meet the criteria for alcohol use disorder (AUD). Research and prevention efforts commonly assume that binge drinking reflects a lack of knowledge about its harmful effects. This implies that people consciously decide to consume large amounts. Another possibility is that each drink presents its own low-stakes decision: whether to have one (or one more) drink. For the study in Alcohol: Clinical & Experimental Research, investigators at Cornell University examined drinking decisions through the lens of “fuzzy-trace theory,” which involves varying framings of choices that involve risk. Fuzzy processing may shape decisions about alcohol use as a series of drink-by-drink choices rather than a decision to consume, say, 5 drinks in a night.

The researchers worked with 351 college students aged 18–31; 3 in 4 were women. The participants took surveys assessing their perceived risk of one drink, of heavy drinking, and of drinking consequences, and their overall sensitivity to risk. They also provided information on their recent drinking and experiences of negative consequences (such as risky driving or embarrassment) and were screened for dangerous drinking and AUD. Each participant was asked how likely they would be at a hypothetical party to get a first drink, then a second, and so on, up to 8. The researchers used statistical analysis to explore varying perceptions of risk related to alcohol use and their associations with measures of participants' drinking behaviors: drinks consumed per week, peak blood alcohol content (BAC), binge drinking in the last month, and criteria for dangerous drinking or AUD.

Close to 1 in 4 participants reported binge drinking in the past month, and 1 in 3 met criteria for hazardous drinking. Their perceived risk of one drink strongly predicted alcohol-related decision-making when choices were made one drink at a time. Those who perceived no risk in a single drink drank more and experienced greater alcohol consequences than those who saw low risk in one drink. Participants who perceived less risk in a single drink were more likely to start and continue drinking than those who associated one drink with higher risk. This effect continued for five drinks, equivalent to the threshold for binge drinking. These participants also reported more drinks per week, higher peak BAC, and more alcohol binges, and scored higher o

当饮酒选择被视为 "只喝一杯",每喝一杯都代表着相对较小的风险时,它可能会具有讽刺意味地导致更严重的饮酒和与酒精相关的伤害。这是一项探索暴饮决策过程的新研究的发现。更好地了解人们如何看待大量偶发性饮酒,可以为预防和干预方法提供参考,并有助于减少饮酒带来的严重负面影响。青壮年尤其易受高风险饮酒及其后果的影响;29%的人最近曾暴饮,15%的人符合酒精使用障碍(AUD)的标准。研究和预防工作通常认为,酗酒反映了人们对其有害影响缺乏了解。这意味着人们有意识地决定大量饮酒。另一种可能是,每次饮酒都是一个低风险的决定:是否喝一杯(或多喝一杯)。在《酒精:临床与实验研究》(Alcohol:的研究中,康奈尔大学的研究人员从 "模糊轨迹理论 "的角度研究了饮酒决策。模糊处理可能会将饮酒决策塑造成一系列逐次饮酒的选择,而不是决定一晚喝 5 杯酒。研究人员对 351 名 18-31 岁的大学生进行了调查,其中每 4 人中就有 3 人是女性。研究人员对参与者进行了调查,评估他们对一杯酒、大量饮酒和饮酒后果的风险感知,以及他们对风险的总体敏感度。他们还提供了近期饮酒的信息和负面后果的经历(如危险驾驶或尴尬),并接受了危险饮酒和 AUD 筛查。每位参与者都被问及,在一个假设的聚会上,他们有多大可能喝第一杯酒,然后是第二杯,依此类推,直至8杯。研究人员利用统计分析探讨了与饮酒有关的不同风险认知及其与参与者饮酒行为测量指标之间的关联:每周饮酒量、血液酒精含量峰值(BAC)、上个月的酗酒情况以及危险饮酒或 AUD 标准。当每次选择一种饮酒方式时,他们对一种饮酒方式风险的感知强烈地预示着与酒精有关的决策。认为一次饮酒无风险的人比认为一次饮酒风险低的人饮酒更多,经历的酒精后果也更严重。与认为一杯酒风险较高的人相比,认为一杯酒风险较低的人更有可能开始并继续饮酒。这种效应持续到五次饮酒,相当于暴饮的阈值。与认为一杯酒的风险较高的人相比,这些人每周饮酒的次数更多,酒精浓度峰值更高,酗酒次数更多,在危险饮酒和酒精相关危害的量表上得分更高。中度饮酒者和禁酒者比大量饮酒者更能规避风险,也更有可能认为单次饮酒的风险更大。对大量饮酒的风险认知较高与接受第四、第五、第六、第七或第八次饮酒的可能性较低有关。"一次饮酒 "的思维方式可以预测对酒精的风险决策,这一发现支持了模糊痕迹理论在饮酒决策中的相关性。一次假想饮酒的感知风险预示着现实世界中的饮酒行为和发生 AUD 的可能性。对于那些认为一杯酒的风险为零的人来说,AUD 的风险尤其高。与后来的饮酒决策相比,早期饮酒决策对饮酒和酒精结果的影响可能更大。这项研究对限制饮酒信息的有效性提出了质疑,因为限制饮酒信息可能暗示少量饮酒没有风险。相反,减少危害的信息可以解决人们对喝一杯酒的安全性的看法。未来的研究可以确定促使人们做出拒绝过早饮酒决定的其他过程。还可以研究这些发现是否与其他自我调节挑战有关,这些挑战可能也涉及对少量酒做出连续决定,而不是对大量酒做出单一决定,如赌博、拖延症和暴饮暴食:有害饮酒的模糊轨迹理论模型。B. Hayes, V. Reyna, S. Edelson.(pp.889-902)某些饮酒行为,不仅仅是饮酒量,可能会预测一个人经历酒精诱发昏厥的可能性。
{"title":"Articles of Public Interest","authors":"","doi":"10.1111/acer.15343","DOIUrl":"https://doi.org/10.1111/acer.15343","url":null,"abstract":"<p>When drinking choices are perceived as “just one drink,” with each single drink representing relatively slight risk, it may ironically lead to heavier drinking and alcohol-related harms. That's the finding of a novel study exploring the decision-making process around binge drinking. A better understanding of how people think about heavy episodic drinking could inform prevention and intervention approaches and help reduce the serious negative consequences of alcohol use. Young adults are especially vulnerable to high-risk drinking and its consequences; 29% are recent binge drinkers, and 15% meet the criteria for alcohol use disorder (AUD). Research and prevention efforts commonly assume that binge drinking reflects a lack of knowledge about its harmful effects. This implies that people consciously decide to consume large amounts. Another possibility is that each drink presents its own low-stakes decision: whether to have one (or one more) drink. For the study in <i>Alcohol: Clinical &amp; Experimental Research</i>, investigators at Cornell University examined drinking decisions through the lens of “fuzzy-trace theory,” which involves varying framings of choices that involve risk. Fuzzy processing may shape decisions about alcohol use as a series of drink-by-drink choices rather than a decision to consume, say, 5 drinks in a night.</p><p>The researchers worked with 351 college students aged 18–31; 3 in 4 were women. The participants took surveys assessing their perceived risk of one drink, of heavy drinking, and of drinking consequences, and their overall sensitivity to risk. They also provided information on their recent drinking and experiences of negative consequences (such as risky driving or embarrassment) and were screened for dangerous drinking and AUD. Each participant was asked how likely they would be at a hypothetical party to get a first drink, then a second, and so on, up to 8. The researchers used statistical analysis to explore varying perceptions of risk related to alcohol use and their associations with measures of participants' drinking behaviors: drinks consumed per week, peak blood alcohol content (BAC), binge drinking in the last month, and criteria for dangerous drinking or AUD.</p><p>Close to 1 in 4 participants reported binge drinking in the past month, and 1 in 3 met criteria for hazardous drinking. Their perceived risk of one drink strongly predicted alcohol-related decision-making when choices were made one drink at a time. Those who perceived no risk in a single drink drank more and experienced greater alcohol consequences than those who saw low risk in one drink. Participants who perceived less risk in a single drink were more likely to start and continue drinking than those who associated one drink with higher risk. This effect continued for five drinks, equivalent to the threshold for binge drinking. These participants also reported more drinks per week, higher peak BAC, and more alcohol binges, and scored higher o","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.15343","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140844718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of childhood trauma and traumatic stress on a woman's risk of having a child with a fetal alcohol spectrum disorder 童年创伤和创伤应激对妇女生育胎儿酒精谱系障碍患儿风险的影响
Pub Date : 2024-05-03 DOI: 10.1111/acer.15334
Michelle Parker, Philip A. May, Anna-Susan Marais, Marlene de Vries, Wendy O. Kalberg, David Buckley, Julie Hasken, H. Eugene Hoyme, Soraya Seedat

Background

Maternal risk factors for having a child diagnosed on the fetal alcohol spectrum disorders (FASD) continuum are complex and include not only the quantity, frequency, and timing of alcohol use but also a woman's physical stature, socio-economic status, and pregnancy-related factors. Exposure to trauma may predispose women to a range of physiological and mental disorders. A woman's mental and physical health may in turn influence her probability of having a child with FASD. This study investigated the role of maternal childhood trauma and lifetime traumatic stress on prenatal alcohol consumption and on the risk of having a child with FASD.

Methods

A nested, case-control study was conducted for maternal risk assessment. Study participants were mothers of first-grade learners from five rural communities in the Western Cape Province of South Africa who were assessed for FASD. Face-to-face surveys were conducted, which included mental health and trauma assessment questionnaires.

Results

In logistic regression analyses, higher maternal childhood trauma scores were associated with an increased likelihood of having a child diagnosed with FASD, although the increase in risk was modest (OR = 1.014, p = 0.015). In addition, structural equation modeling investigated relationships between maternal drinking, childhood trauma, traumatic stress, and a child's FASD diagnosis. Traumatic stress and drinking during pregnancy, but not lifetime alcohol use, were associated with maternal childhood trauma. Lifetime alcohol use influenced drinking during pregnancy, which in turn was significantly associated with having a child diagnosed on the continuum of FASD.

Conclusion

No direct influence of maternal childhood trauma on FASD diagnosis could be demonstrated. However, maternal trauma may indirectly contribute to the risk of having a child diagnosed with FASD.

孕产妇被诊断为胎儿酒精中毒综合症(FASD)的风险因素非常复杂,不仅包括饮酒的数量、频率和时间,还包括妇女的身材、社会经济地位以及与妊娠有关的因素。遭受创伤可能会导致妇女出现一系列生理和心理疾病。妇女的身心健康反过来又会影响其生育 FASD 患儿的概率。本研究调查了母亲的童年创伤和终生创伤压力对产前饮酒量和生育 FASD 患儿风险的影响。
{"title":"Influence of childhood trauma and traumatic stress on a woman's risk of having a child with a fetal alcohol spectrum disorder","authors":"Michelle Parker,&nbsp;Philip A. May,&nbsp;Anna-Susan Marais,&nbsp;Marlene de Vries,&nbsp;Wendy O. Kalberg,&nbsp;David Buckley,&nbsp;Julie Hasken,&nbsp;H. Eugene Hoyme,&nbsp;Soraya Seedat","doi":"10.1111/acer.15334","DOIUrl":"10.1111/acer.15334","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Maternal risk factors for having a child diagnosed on the fetal alcohol spectrum disorders (FASD) continuum are complex and include not only the quantity, frequency, and timing of alcohol use but also a woman's physical stature, socio-economic status, and pregnancy-related factors. Exposure to trauma may predispose women to a range of physiological and mental disorders. A woman's mental and physical health may in turn influence her probability of having a child with FASD. This study investigated the role of maternal childhood trauma and lifetime traumatic stress on prenatal alcohol consumption and on the risk of having a child with FASD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A nested, case-control study was conducted for maternal risk assessment. Study participants were mothers of first-grade learners from five rural communities in the Western Cape Province of South Africa who were assessed for FASD. Face-to-face surveys were conducted, which included mental health and trauma assessment questionnaires.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In logistic regression analyses, higher maternal childhood trauma scores were associated with an increased likelihood of having a child diagnosed with FASD, although the increase in risk was modest (OR = 1.014, <i>p</i> = 0.015). In addition, structural equation modeling investigated relationships between maternal drinking, childhood trauma, traumatic stress, and a child's FASD diagnosis. Traumatic stress and drinking during pregnancy, but not lifetime alcohol use, were associated with maternal childhood trauma. Lifetime alcohol use influenced drinking during pregnancy, which in turn was significantly associated with having a child diagnosed on the continuum of FASD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>No direct influence of maternal childhood trauma on FASD diagnosis could be demonstrated. However, maternal trauma may indirectly contribute to the risk of having a child diagnosed with FASD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.15334","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140838578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lower resting state functional connectivity partially mediates adverse effects of prenatal alcohol exposure on arithmetic performance in children 较低的静息状态功能连通性部分介导了产前酒精暴露对儿童算术成绩的不良影响。
Pub Date : 2024-05-02 DOI: 10.1111/acer.15332
Jia Fan, Keri J. Woods, Joseph L. Jacobson, Paul A. Taylor, Jadrana T. F. Toich, Christopher D. Molteno, Sandra W. Jacobson, Ernesta M. Meintjes

Background

Fetal alcohol spectrum disorders (FASD) include a range of neurocognitive and behavioral impairments resulting from prenatal alcohol exposure (PAE). Among the PAE-related cognitive deficits, number processing is particularly affected. This study examines alterations in number processing networks and whether changes in functional connectivity mediate the adverse effects of PAE on arithmetic performance.

Methods

Magnetic resonance imaging (MRI) was acquired in 57 children (mean (SD) age = 11.3 (+0.9) yr), 38 with FASD (19 fetal alcohol syndrome (FAS) or partial FAS (PFAS), 19 heavily exposed (HE)) and 19 controls. Whole-brain correlation analyses were performed from five seeds located in regions involved in number processing.

Results

Children with FAS/PFAS showed dose-dependent reductions in resting state functional connectivity between the seed in the right (R) posterior superior parietal lobule and a cluster in the left (L) inferior frontal gyrus, and between a seed in the R horizontal intraparietal sulcus and clusters in the R precentral gyrus and L cerebellar lobule VI. HE children showed lower resting state functional connectivity in a subset of these regions. Lower functional connectivity in the two fronto-parietal connections partially mediated the adverse effects of PAE on arithmetic performance.

Conclusion

This study demonstrates PAE-related functional connectivity impairments in functional networks involved in number processing. The weaker connectivity between the R posterior superior parietal lobule and the L inferior frontal gyrus suggests that impaired verbal processing and visuospatial working memory may play a role in number processing deficits, while weaker connectivity between the R intraparietal sulcus and the R precentral gyrus points to poorer finger-based numerical representation, which has been linked to arithmetic computational skills.

背景:胎儿酒精谱系障碍(FASD)包括产前酒精暴露(PAE)导致的一系列神经认知和行为障碍。在与 PAE 相关的认知缺陷中,数字处理尤其受到影响。本研究探讨了数字处理网络的改变,以及功能连接的变化是否介导了 PAE 对算术成绩的不良影响:对 57 名儿童(平均(标清)年龄 = 11.3 (+0.9) 岁)进行了磁共振成像(MRI)检查,其中 38 名儿童患有 FASD(19 名患有胎儿酒精综合征(FAS)或部分 FAS(PFAS),19 名患有严重暴露(HE)),19 名儿童为对照组。对涉及数字处理区域的五颗种子进行了全脑相关性分析:结果:FAS/PFAS 患儿的右侧顶叶后上小叶种子与左侧额叶下回集群之间的静息状态功能连通性,以及右侧顶叶内水平沟种子与右侧中央前回集群和左侧小脑第六小叶之间的静息状态功能连通性,均显示出剂量依赖性降低。HE 儿童在这些区域中的一部分表现出较低的静息状态功能连通性。这两个前顶叶连接区较低的功能连接部分介导了PAE对算术成绩的不良影响:结论:本研究表明,在涉及数字处理的功能网络中,存在与 PAE 相关的功能连接损伤。R后顶叶上小叶和L额叶下回之间较弱的连接性表明,言语处理和视觉空间工作记忆受损可能在数字处理缺陷中起作用,而R顶叶内沟和R中央前回之间较弱的连接性表明,基于手指的数字表征能力较差,这与算术计算技能有关。
{"title":"Lower resting state functional connectivity partially mediates adverse effects of prenatal alcohol exposure on arithmetic performance in children","authors":"Jia Fan,&nbsp;Keri J. Woods,&nbsp;Joseph L. Jacobson,&nbsp;Paul A. Taylor,&nbsp;Jadrana T. F. Toich,&nbsp;Christopher D. Molteno,&nbsp;Sandra W. Jacobson,&nbsp;Ernesta M. Meintjes","doi":"10.1111/acer.15332","DOIUrl":"10.1111/acer.15332","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Fetal alcohol spectrum disorders (FASD) include a range of neurocognitive and behavioral impairments resulting from prenatal alcohol exposure (PAE). Among the PAE-related cognitive deficits, number processing is particularly affected. This study examines alterations in number processing networks and whether changes in functional connectivity mediate the adverse effects of PAE on arithmetic performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Magnetic resonance imaging (MRI) was acquired in 57 children (mean (SD) age = 11.3 (+0.9) yr), 38 with FASD (19 fetal alcohol syndrome (FAS) or partial FAS (PFAS), 19 heavily exposed (HE)) and 19 controls. Whole-brain correlation analyses were performed from five seeds located in regions involved in number processing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Children with FAS/PFAS showed dose-dependent reductions in resting state functional connectivity between the seed in the right (R) posterior superior parietal lobule and a cluster in the left (L) inferior frontal gyrus, and between a seed in the R horizontal intraparietal sulcus and clusters in the R precentral gyrus and L cerebellar lobule VI. HE children showed lower resting state functional connectivity in a subset of these regions. Lower functional connectivity in the two fronto-parietal connections partially mediated the adverse effects of PAE on arithmetic performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study demonstrates PAE-related functional connectivity impairments in functional networks involved in number processing. The weaker connectivity between the R posterior superior parietal lobule and the L inferior frontal gyrus suggests that impaired verbal processing and visuospatial working memory may play a role in number processing deficits, while weaker connectivity between the R intraparietal sulcus and the R precentral gyrus points to poorer finger-based numerical representation, which has been linked to arithmetic computational skills.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.15332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current and ideal living arrangements and supports for Canadian adults with fetal alcohol spectrum disorder: Part II—Perspectives from caregivers 患有胎儿酒精谱系障碍的加拿大成年人目前和理想的生活安排与支持:第二部分--来自照顾者的观点
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-04-29 DOI: 10.1111/acer.15337
Siann Gault, Lauren Gnat, Paula C. Fletcher, Maritt Kirst, Lauren O'Neill, Robert MacDonald, Melody E. Morton Ninomiya

Background

Caregivers supporting adults with fetal alcohol spectrum disorder (FASD) report concerns regarding living arrangements and services for their adult children with FASD. Best practices for living support for adults with FASD are under-researched, and few studies have explored the experiences of caregivers whose children are adults. This study examined the perspectives of caregivers who support adults (18+) with FASD regarding: (1) current ways adults with FASD are supported with daily life activities; and (2) ideal future living arrangements and supports.

Methods

This article presents findings from the perspective of caregivers who support adults with FASD, as part of a broader project involving both adults with FASD and caregivers. Semi-structured interviews were conducted with 11 Canadian caregivers who live at home with an adult with FASD (aged 18+). Responses were examined using framework analysis, a structured approach to analyzing qualitative data.

Results

Caregivers described their experiences and perspectives regarding: (1) current ways adults with FASD are supported in their daily activities; (2) strategies for successful support; (3) ideal future living arrangements and supports; and (4) concerns for the future. Notably, almost every participant raised pressing concerns regarding the future living arrangements for the person they support once they are no longer able to provide care.

Conclusions

This study explores caregivers' perspectives regarding living support needed by adults with FASD, which can inform support programs and housing services. Findings demonstrate an urgent need for policy change directed toward developing available, affordable, and appropriate housing for adults with FASD.

为患有胎儿酒精谱系障碍(FASD)的成年患者提供支持的照顾者对其患有 FASD 的成年子女的生活安排和服务表示担忧。对 FASD 成人生活支持的最佳实践研究不足,很少有研究探讨子女已成年的照顾者的经验。本研究探讨了为患有 FASD 的成人(18 岁以上)提供支持的照顾者对以下问题的看法:(1)目前为患有 FASD 的成人提供日常生活活动支持的方式;(2)未来理想的生活安排和支持。
{"title":"Current and ideal living arrangements and supports for Canadian adults with fetal alcohol spectrum disorder: Part II—Perspectives from caregivers","authors":"Siann Gault,&nbsp;Lauren Gnat,&nbsp;Paula C. Fletcher,&nbsp;Maritt Kirst,&nbsp;Lauren O'Neill,&nbsp;Robert MacDonald,&nbsp;Melody E. Morton Ninomiya","doi":"10.1111/acer.15337","DOIUrl":"10.1111/acer.15337","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Caregivers supporting adults with fetal alcohol spectrum disorder (FASD) report concerns regarding living arrangements and services for their adult children with FASD. Best practices for living support for adults with FASD are under-researched, and few studies have explored the experiences of caregivers whose children are adults. This study examined the perspectives of caregivers who support adults (18+) with FASD regarding: (1) current ways adults with FASD are supported with daily life activities; and (2) ideal future living arrangements and supports.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This article presents findings from the perspective of caregivers who support adults with FASD, as part of a broader project involving both adults with FASD and caregivers. Semi-structured interviews were conducted with 11 Canadian caregivers who live at home with an adult with FASD (aged 18+). Responses were examined using framework analysis, a structured approach to analyzing qualitative data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Caregivers described their experiences and perspectives regarding: (1) current ways adults with FASD are supported in their daily activities; (2) strategies for successful support; (3) ideal future living arrangements and supports; and (4) concerns for the future. Notably, almost every participant raised pressing concerns regarding the future living arrangements for the person they support once they are no longer able to provide care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study explores caregivers' perspectives regarding living support needed by adults with FASD, which can inform support programs and housing services. Findings demonstrate an urgent need for policy change directed toward developing available, affordable, and appropriate housing for adults with FASD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.15337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140838584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current and ideal living arrangements and supports for Canadian adults with fetal alcohol spectrum disorder (FASD)—Part I: Perspectives from adults with FASD 加拿大患有胎儿酒精谱系障碍(FASD)的成年人目前和理想的生活安排与支持--第一部分:患有 FASD 的成年人的观点
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-04-29 DOI: 10.1111/acer.15336
Siann Gault, Lauren Gnat, Paula C. Fletcher, Maritt Kirst, Robert MacDonald, Melody E. Morton Ninomiya

Background

Adults with fetal alcohol spectrum disorder (FASD) can thrive with lifelong support in daily living activities. Previous research examining living support for adults with FASD has heavily relied on caregiver reports rather than lived experiences, which can undermine opportunities for self-determination. In this study, we examined the perspectives of adults with FASD to better understand: (1) the ways in which they are supported with daily life activities; and (2) their ideal future living arrangements and supports.

Methods

This article presents findings from the perspective of adults with FASD as part of a broader project involving both adults with FASD and the caregivers who support them. Interviews were conducted with four Canadian adults with FASD who live in housing with supportive services and seven adults with FASD who live at home with the support of caregivers. Framework analyses, a structured approach to analyzing qualitative data, were used to examine participants' perspectives.

Results

In addition to providing support for previous findings, participants provided novel information regarding: (1) their daily living supports; (2) positive and negative aspects of their arrangements; and (3) ideal living environments and supports.

Conclusions

This study offers insight into participants' perspectives regarding their living support, which is critical to inform housing and aid in self-determination. Areas of support outlined by participants can be used to begin conversations regarding the support required in housing arrangements for adults with FASD.

患有胎儿酒精谱系障碍(FASD)的成年人可以在日常生活活动中获得终身支持,从而茁壮成长。以往对 FASD 成年人生活支持的研究主要依赖于照顾者的报告,而不是生活经验,这可能会破坏自我决定的机会。在这项研究中,我们考察了患有 FASD 的成年人的观点,以便更好地了解:(1)他们在日常生活活动中获得支持的方式;以及(2)他们理想的未来生活安排和支持。
{"title":"Current and ideal living arrangements and supports for Canadian adults with fetal alcohol spectrum disorder (FASD)—Part I: Perspectives from adults with FASD","authors":"Siann Gault,&nbsp;Lauren Gnat,&nbsp;Paula C. Fletcher,&nbsp;Maritt Kirst,&nbsp;Robert MacDonald,&nbsp;Melody E. Morton Ninomiya","doi":"10.1111/acer.15336","DOIUrl":"10.1111/acer.15336","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Adults with fetal alcohol spectrum disorder (FASD) can thrive with lifelong support in daily living activities. Previous research examining living support for adults with FASD has heavily relied on caregiver reports rather than lived experiences, which can undermine opportunities for self-determination. In this study, we examined the perspectives of adults with FASD to better understand: (1) the ways in which they are supported with daily life activities; and (2) their ideal future living arrangements and supports.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This article presents findings from the perspective of adults with FASD as part of a broader project involving both adults with FASD and the caregivers who support them. Interviews were conducted with four Canadian adults with FASD who live in housing with supportive services and seven adults with FASD who live at home with the support of caregivers. Framework analyses, a structured approach to analyzing qualitative data, were used to examine participants' perspectives.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In addition to providing support for previous findings, participants provided novel information regarding: (1) their daily living supports; (2) positive and negative aspects of their arrangements; and (3) ideal living environments and supports.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study offers insight into participants' perspectives regarding their living support, which is critical to inform housing and aid in self-determination. Areas of support outlined by participants can be used to begin conversations regarding the support required in housing arrangements for adults with FASD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.15336","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140838381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating cognitive and motivational proximal outcomes in a randomized clinical trial of writing about the future self to reduce drinking 调查 "书写未来的自己以减少饮酒 "随机临床试验的认知和动机近端结果
Pub Date : 2024-04-24 DOI: 10.1111/acer.15326
Kristen P. Lindgren, Scott A. Baldwin, Ethan Kross, Jason J. Ramirez, Ty Tristao, Kirsten P. Peterson, Bethany A. Teachman, Reinout W. Wiers, Clayton Neighbors

Background

Drinking identity (the extent to which one links the self with drinking alcohol) is a unique risk factor for college students' hazardous drinking that is not directly targeted by existing interventions. We conducted a study that aimed to decrease drinking identity among college students with hazardous drinking. We adapted a writing task about the future self and tested whether three writing sessions could decrease drinking identity and change drinking. We also investigated whether two additional factors (writing perspective and inclusion of participants' social networks) would enhance task impact. The present study evaluated whether posited proximal cognitive and motivational outcomes (drinking identity, self-efficacy, readiness to change, and drinking intentions) changed immediately after each writing session.

Method

The study is a randomized clinical trial in which hypotheses and analyses were pre-registered. Participants were 328 college students who met hazardous drinking criteria. The study had a 2 (narrative writing topic: low-risk drinker vs. reduced smartphone use) × 2 (writing perspective: first-person vs. non-first-person) × 2 (social network instruction: instructed to include vs. not) factorial design. Proximal outcomes were drinking identity, self-efficacy, readiness to change, and drinking intentions. The clinical outcome was alcohol consumption. Participants completed three laboratory sessions at weekly intervals that included the writing task and pre- and post-task assessments.

Results

Results were largely null, except that readiness to reduce drinking was higher in the low-risk drinker condition and increased over the lab sessions. Time effects indicated that reductions in drinking identity, drinking intentions, and alcohol consumption, and increases in self-efficacy were observed but did not change above and beyond control conditions.

Conclusions

Findings indicate the need to strengthen the writing task and select a more appropriate control task to target proposed proximal outcomes. Future studies might try personalizing the task, evaluating its efficacy with individuals motivated to change their drinking, and using a control task that does not involve imagining a future self.

饮酒认同(将自我与饮酒联系起来的程度)是大学生危险饮酒的一个独特风险因素,而现有干预措施并未直接针对这一因素。我们开展了一项研究,旨在降低有饮酒危险的大学生的饮酒认同感。我们改编了一个关于未来自我的写作任务,并测试了三次写作是否能减少饮酒认同并改变饮酒。我们还调查了两个附加因素(写作视角和纳入参与者的社交网络)是否会增强任务效果。本研究评估了假设的近端认知和动机结果(饮酒认同、自我效能感、改变意愿和饮酒意向)是否会在每次写作后立即发生变化。
{"title":"Investigating cognitive and motivational proximal outcomes in a randomized clinical trial of writing about the future self to reduce drinking","authors":"Kristen P. Lindgren,&nbsp;Scott A. Baldwin,&nbsp;Ethan Kross,&nbsp;Jason J. Ramirez,&nbsp;Ty Tristao,&nbsp;Kirsten P. Peterson,&nbsp;Bethany A. Teachman,&nbsp;Reinout W. Wiers,&nbsp;Clayton Neighbors","doi":"10.1111/acer.15326","DOIUrl":"10.1111/acer.15326","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Drinking identity (the extent to which one links the self with drinking alcohol) is a unique risk factor for college students' hazardous drinking that is not directly targeted by existing interventions. We conducted a study that aimed to decrease drinking identity among college students with hazardous drinking. We adapted a writing task about the future self and tested whether three writing sessions could decrease drinking identity and change drinking. We also investigated whether two additional factors (writing perspective and inclusion of participants' social networks) would enhance task impact. The present study evaluated whether posited proximal cognitive and motivational outcomes (drinking identity, self-efficacy, readiness to change, and drinking intentions) changed immediately after each writing session.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>The study is a randomized clinical trial in which hypotheses and analyses were pre-registered. Participants were 328 college students who met hazardous drinking criteria. The study had a 2 (narrative writing topic: low-risk drinker vs. reduced smartphone use) × 2 (writing perspective: first-person vs. non-first-person) × 2 (social network instruction: instructed to include vs. not) factorial design. Proximal outcomes were drinking identity, self-efficacy, readiness to change, and drinking intentions. The clinical outcome was alcohol consumption. Participants completed three laboratory sessions at weekly intervals that included the writing task and pre- and post-task assessments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Results were largely null, except that readiness to reduce drinking was higher in the low-risk drinker condition and increased over the lab sessions. Time effects indicated that reductions in drinking identity, drinking intentions, and alcohol consumption, and increases in self-efficacy were observed but did not change above and beyond control conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Findings indicate the need to strengthen the writing task and select a more appropriate control task to target proposed proximal outcomes. Future studies might try personalizing the task, evaluating its efficacy with individuals motivated to change their drinking, and using a control task that does not involve imagining a future self.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140797770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term trends in beverage-specific drinking in the National Alcohol Surveys: Differences by sex, age, and race and ethnicity 全国酒精调查中特定饮料饮酒的长期趋势:性别、年龄、种族和民族的差异
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-04-24 DOI: 10.1111/acer.15335
William C. Kerr, Camillia K. Lui, Yu Ye, Libo Li, Thomas Greenfield, Katherine J. Karriker-Jaffe, Priscilla Martinez

Background

Despite substantial declines in underage drinking and binge drinking, alcohol consumption has increased in the past 30 years. This study examined how beverage-specific drinking patterns varied by sex, age, and race and ethnicity from 1979 to 2020.

Methods

Secondary data analysis was conducted on pooled data from the National Alcohol Survey series from 1979 to 2020 of a sample of U.S. adults ages 18 years or older. Total and beverage-specific volume were calculated from graduated frequency questions on reported beverage type, which included beer, wine, and spirits. Sex-stratified analyses focused on descriptive trends of each alcohol measure over time and by age and race and ethnicity. Time-varying effect models were also conducted to identify subgroups at higher risk for increased consumption over time.

Results

Women's drinking increased, with alcohol volume rising substantially from 2000 to 2020; the largest increase was among women 30 and older. Men's alcohol volume also rose over this period but remained below the levels of 1979 and 1984, with older adults increasing their consumption those 18–29 decreased their drinking. Beverage-specific trends showed some similarities by gender: in 2020, wine volume was at its highest level for both women and men, while spirits volume also was at its highest level for men and in women was tied with the 1979 peak in spirits consumption. Increases were also found among Black men and women and Latina women from 2000 to 2020.

Conclusions

Given the increases in alcohol volume, particularly among women and older age groups, alcohol policy, interventions, and education should consider ways to reduce harms associated with alcohol use among these groups. Continued monitoring of beverage-specific drinking patterns is needed to track policy-relevant changes.

尽管未成年人饮酒和酗酒现象大幅减少,但在过去 30 年中,酒精消费量却有所增加。本研究考察了从 1979 年到 2020 年,不同性别、年龄、种族和民族的特定饮料饮酒模式的变化情况。
{"title":"Long-term trends in beverage-specific drinking in the National Alcohol Surveys: Differences by sex, age, and race and ethnicity","authors":"William C. Kerr,&nbsp;Camillia K. Lui,&nbsp;Yu Ye,&nbsp;Libo Li,&nbsp;Thomas Greenfield,&nbsp;Katherine J. Karriker-Jaffe,&nbsp;Priscilla Martinez","doi":"10.1111/acer.15335","DOIUrl":"10.1111/acer.15335","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite substantial declines in underage drinking and binge drinking, alcohol consumption has increased in the past 30 years. This study examined how beverage-specific drinking patterns varied by sex, age, and race and ethnicity from 1979 to 2020.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Secondary data analysis was conducted on pooled data from the National Alcohol Survey series from 1979 to 2020 of a sample of U.S. adults ages 18 years or older. Total and beverage-specific volume were calculated from graduated frequency questions on reported beverage type, which included beer, wine, and spirits. Sex-stratified analyses focused on descriptive trends of each alcohol measure over time and by age and race and ethnicity. Time-varying effect models were also conducted to identify subgroups at higher risk for increased consumption over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Women's drinking increased, with alcohol volume rising substantially from 2000 to 2020; the largest increase was among women 30 and older. Men's alcohol volume also rose over this period but remained below the levels of 1979 and 1984, with older adults increasing their consumption those 18–29 decreased their drinking. Beverage-specific trends showed some similarities by gender: in 2020, wine volume was at its highest level for both women and men, while spirits volume also was at its highest level for men and in women was tied with the 1979 peak in spirits consumption. Increases were also found among Black men and women and Latina women from 2000 to 2020.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Given the increases in alcohol volume, particularly among women and older age groups, alcohol policy, interventions, and education should consider ways to reduce harms associated with alcohol use among these groups. Continued monitoring of beverage-specific drinking patterns is needed to track policy-relevant changes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140797777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Participant diversity in ACER: 2010–2022 ACER 参与者的多样性:2010-2022 年
Pub Date : 2024-04-23 DOI: 10.1111/acer.15324
Heather A. Kissel, Ga Hee Lee, Sara McFarland, Dexton Berger, Elizabeth Enneking, Jenna Dunham, Ty Brumback

Background

Increasing diversity has become a priority for all fields working with human subjects due to historic exclusions and misrepresentations of participants with minoritized identities. To create a more representative and generalizable science of alcohol use, the Research Society on Alcohol (RSA) and its official journal, Alcohol: Clinical and Experimental Research (ACER), have increasingly incorporated diversity and inclusion into their posted values and programming.

Methods

We analyzed the content of articles published in ACER from 2010 through 2022 (6 years before and after the formation of RSA's Diversity Committee) to assess the reporting of participants' demographic information and whether there has been increased inclusion of diverse samples in alcohol research over time. Our team screened 3292 abstracts for data extraction; studies were included if they were primary analyses of data collected from human subjects (n = 1043).

Results

Reporting of all demographic variables increased over time, with significant increases in reporting for race/ethnicity, sexual orientation, gender identity, socioeconomic status (SES), income, and educational attainment. Demographic variables were also increasingly used in analyses. However, representation of research outside the United States diminished significantly over time.

Conclusions

We provide recommended journal article reporting standards for ACER to continue the positive progress in reporting demographics in alcohol research and facilitate meta-analyses examining demographic modulation and the impact of social determinants of health.

由于历史上对少数身份参与者的排斥和误解,提高多样性已成为所有以人为研究对象的领域的首要任务。为了建立更具代表性和普适性的酒精使用科学,酒精研究协会(RSA)及其官方期刊《酒精:临床与实验研究》(ACER)越来越多地将多样性和包容性纳入其中:临床与实验研究》(ACER)越来越多地将多样性和包容性纳入其发布的价值观和计划中。
{"title":"Participant diversity in ACER: 2010–2022","authors":"Heather A. Kissel,&nbsp;Ga Hee Lee,&nbsp;Sara McFarland,&nbsp;Dexton Berger,&nbsp;Elizabeth Enneking,&nbsp;Jenna Dunham,&nbsp;Ty Brumback","doi":"10.1111/acer.15324","DOIUrl":"10.1111/acer.15324","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Increasing diversity has become a priority for all fields working with human subjects due to historic exclusions and misrepresentations of participants with minoritized identities. To create a more representative and generalizable science of alcohol use, the Research Society on Alcohol (RSA) and its official journal, <i>Alcohol: Clinical and Experimental Research</i> (<i>ACER</i>), have increasingly incorporated diversity and inclusion into their posted values and programming.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed the content of articles published in <i>ACER</i> from 2010 through 2022 (6 years before and after the formation of RSA's Diversity Committee) to assess the reporting of participants' demographic information and whether there has been increased inclusion of diverse samples in alcohol research over time. Our team screened 3292 abstracts for data extraction; studies were included if they were primary analyses of data collected from human subjects (<i>n</i> = 1043).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Reporting of all demographic variables increased over time, with significant increases in reporting for race/ethnicity, sexual orientation, gender identity, socioeconomic status (SES), income, and educational attainment. Demographic variables were also increasingly used in analyses. However, representation of research outside the United States diminished significantly over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We provide recommended journal article reporting standards for <i>ACER</i> to continue the positive progress in reporting demographics in alcohol research and facilitate meta-analyses examining demographic modulation and the impact of social determinants of health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140797768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex differences in neural response to an acute stressor in individuals with an alcohol use disorder 酒精使用障碍患者对急性应激源的神经反应的性别差异
Pub Date : 2024-04-23 DOI: 10.1111/acer.15301
Erica N. Grodin, Dylan Kirsch, Malia Belnap, Lara A. Ray

Background

Alcohol use disorder (AUD) and stress influence overlapping neural circuits in the brain. The literature is mixed regarding the presence of sex differences in the neural response to acute stressors, and this issue has not been examined in individuals with AUD. We validated a stress functional magnetic resonance imaging (fMRI) paradigm in individuals with AUD and tested for sex differences.

Methods

Twenty-five treatment-seeking individuals with AUD (15M/10F) were recruited to participate in the neuroimaging study linked to a clinical trial of ibudilast (NCT03594435). To assess social-evaluative stress, participants completed the Montreal Imaging Stress Task (MIST). Whole brain and amygdala region-of-interest analyses were conducted. Subjective ratings of anxiety and distress were collected. Repeated measures ANCOVAs were performed to evaluate the effect of stress on anxiety and distress and to evaluate sex differences.

Results

There were trend-level effects of stress on anxiety ratings and amygdala activation (p's = 0.06). There was a significant effect of stress in the bilateral thalamus, ventral tegmental area, and paracingulate (Z's > 4.09, p's < 0.03). There was a trend-level effect of sex on subjective ratings of stress (p's = 0.07). Females had higher amygdala activation in response to stress (p = 0.02). Females also had greater activation than males in the precuneus, posterior cingulate cortex, and right inferior frontal gyrus during acute stress (Z's > 3.56, p's < 0.03).

Conclusions

This study provides an initial validation of the MIST in a sample of individuals with AUD. It also provides preliminary evidence of sex differences in the response to social-evaluative stress, which is important, given the relevance of stress and negative emotionality as motivators for alcohol use in females.

酒精使用障碍(AUD)和压力会影响大脑中重叠的神经回路。关于神经系统对急性应激源的反应是否存在性别差异,目前的文献说法不一,而这一问题尚未在 AUD 患者中进行研究。我们在 AUD 患者中验证了压力功能磁共振成像(fMRI)范式,并测试了性别差异。
{"title":"Sex differences in neural response to an acute stressor in individuals with an alcohol use disorder","authors":"Erica N. Grodin,&nbsp;Dylan Kirsch,&nbsp;Malia Belnap,&nbsp;Lara A. Ray","doi":"10.1111/acer.15301","DOIUrl":"10.1111/acer.15301","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol use disorder (AUD) and stress influence overlapping neural circuits in the brain. The literature is mixed regarding the presence of sex differences in the neural response to acute stressors, and this issue has not been examined in individuals with AUD. We validated a stress functional magnetic resonance imaging (fMRI) paradigm in individuals with AUD and tested for sex differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty-five treatment-seeking individuals with AUD (15M/10F) were recruited to participate in the neuroimaging study linked to a clinical trial of ibudilast (NCT03594435). To assess social-evaluative stress, participants completed the Montreal Imaging Stress Task (MIST). Whole brain and amygdala region-of-interest analyses were conducted. Subjective ratings of anxiety and distress were collected. Repeated measures ANCOVAs were performed to evaluate the effect of stress on anxiety and distress and to evaluate sex differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were trend-level effects of stress on anxiety ratings and amygdala activation (<i>p</i>'s = 0.06). There was a significant effect of stress in the bilateral thalamus, ventral tegmental area, and paracingulate (<i>Z</i>'s &gt; 4.09, <i>p</i>'s &lt; 0.03). There was a trend-level effect of sex on subjective ratings of stress (<i>p</i>'s = 0.07). Females had higher amygdala activation in response to stress (<i>p</i> = 0.02). Females also had greater activation than males in the precuneus, posterior cingulate cortex, and right inferior frontal gyrus during acute stress (<i>Z</i>'s &gt; 3.56, <i>p</i>'s &lt; 0.03).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides an initial validation of the MIST in a sample of individuals with AUD. It also provides preliminary evidence of sex differences in the response to social-evaluative stress, which is important, given the relevance of stress and negative emotionality as motivators for alcohol use in females.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140797831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modest effect of differential dietary vitamin A intake on the pathogenesis of alcohol-associated liver disease 膳食中维生素 A 摄入量的差异对酒精相关肝病的发病机制影响不大
Pub Date : 2024-04-22 DOI: 10.1111/acer.15329
Afroza Ferdouse, Robin D. Clugston

Background

Chronic alcohol consumption is a major public health issue. The primary organ damaged by alcohol abuse is the liver, leading to alcohol-associated liver disease (ALD). ALD begins with hepatic steatosis and can progress to fibrosis and cirrhosis; however, we have an incomplete understanding of ALD pathogenesis. Interestingly, the liver is also the major organ for vitamin A metabolism and storage, and ALD has previously been linked with altered hepatic vitamin A homeostasis. We hypothesize that alcohol-induced vitamin A depletion disrupts its normal function in the liver, contributing to the pathogenesis of ALD. To test this hypothesis, we postulated that adding copious vitamin A to the diet might alleviate ALD, and conversely, that a vitamin A deficient diet would worsen ALD.

Methods

We conducted two dietary intervention studies in mice comparing deficient (0 IU/g diet) and copious (25 IU/g diet) dietary vitamin A intake versus control (4 IU/g diet), using the NIAAA chronic-binge model of ALD. Hepatic steatosis was assessed using histopathological and biochemical approaches. Tissue Vitamin A levels were measured using high-performance liquid chromatography. Markers of ALD, hepatic inflammation and lipid metabolism were analyzed by the quantitative polymerase chain reaction and western blotting.

Results

As expected, a 0 IU/g Vitamin A diet decreased, and a 25 IU/g Vitamin A diet increased hepatic Vitamin A stores. However, alcohol induced changes in hepatic triglyceride levels, markers of hepatic lipid metabolism, inflammation and fibrosis were not significantly different in mice consuming a copious or deficient vitamin A diet compared to control.

Conclusions

Altered vitamin A intake and hepatic vitamin A storage have a minor effect on the pathogenesis of ALD. Thus, given the known link between altered retinoic acid signaling and ALD, future studies that further explore this linkage are warranted.

长期饮酒是一个重大的公共卫生问题。酗酒损害的主要器官是肝脏,从而导致酒精相关性肝病(ALD)。酒精相关性肝病始于肝脂肪变性,可发展为肝纤维化和肝硬化;然而,我们对酒精相关性肝病的发病机理尚不完全了解。有趣的是,肝脏也是维生素 A 代谢和储存的主要器官,而 ALD 以前与肝脏维生素 A 平衡的改变有关。我们假设,酒精引起的维生素 A 缺乏会破坏其在肝脏中的正常功能,从而导致 ALD 的发病。为了验证这一假设,我们推测在饮食中添加大量维生素 A 可能会缓解 ALD,反之,缺乏维生素 A 的饮食会加重 ALD。
{"title":"Modest effect of differential dietary vitamin A intake on the pathogenesis of alcohol-associated liver disease","authors":"Afroza Ferdouse,&nbsp;Robin D. Clugston","doi":"10.1111/acer.15329","DOIUrl":"10.1111/acer.15329","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic alcohol consumption is a major public health issue. The primary organ damaged by alcohol abuse is the liver, leading to alcohol-associated liver disease (ALD). ALD begins with hepatic steatosis and can progress to fibrosis and cirrhosis; however, we have an incomplete understanding of ALD pathogenesis. Interestingly, the liver is also the major organ for vitamin A metabolism and storage, and ALD has previously been linked with altered hepatic vitamin A homeostasis. We hypothesize that alcohol-induced vitamin A depletion disrupts its normal function in the liver, contributing to the pathogenesis of ALD. To test this hypothesis, we postulated that adding copious vitamin A to the diet might alleviate ALD, and conversely, that a vitamin A deficient diet would worsen ALD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted two dietary intervention studies in mice comparing deficient (0 IU/g diet) and copious (25 IU/g diet) dietary vitamin A intake versus control (4 IU/g diet), using the NIAAA chronic-binge model of ALD. Hepatic steatosis was assessed using histopathological and biochemical approaches. Tissue Vitamin A levels were measured using high-performance liquid chromatography. Markers of ALD, hepatic inflammation and lipid metabolism were analyzed by the quantitative polymerase chain reaction and western blotting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>As expected, a 0 IU/g Vitamin A diet decreased, and a 25 IU/g Vitamin A diet increased hepatic Vitamin A stores. However, alcohol induced changes in hepatic triglyceride levels, markers of hepatic lipid metabolism, inflammation and fibrosis were not significantly different in mice consuming a copious or deficient vitamin A diet compared to control.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Altered vitamin A intake and hepatic vitamin A storage have a minor effect on the pathogenesis of ALD. Thus, given the known link between altered retinoic acid signaling and ALD, future studies that further explore this linkage are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.15329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140797858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Alcohol (Hanover, York County, Pa.)
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1