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Treatment engagement in comorbid alcohol use disorder and alcohol-related liver disease: A qualitative exploration of barriers and facilitators with service users 合并酒精使用障碍和酒精相关肝病的治疗参与度:与服务使用者一起对障碍和促进因素进行定性探索。
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-08-27 DOI: 10.1111/acer.15427
Sofia Hemrage, Stephen Parkin, Nicola Kalk, Naina Shah, Paolo Deluca, Colin Drummond

Background

Effective interventions to improve patient outcomes in comorbid alcohol use disorder (AUD) and alcohol-related liver disease (ARLD) remain a clinical unmet need. While the choice of abstinence is the cornerstone for the prevention of disease progression and mortality, evidence suggests a suboptimal engagement with treatment supporting recovery. This qualitative investigation aims to understand barriers and facilitators to treatment as experienced by this clinical population by applying a multidimensional adherence model proposed by the World Health Organization.

Methods

Twenty-four participants with comorbid AUD and ARLD were recruited from an inpatient clinical setting. Data for this study were collected through semistructured, in-depth interviews. Deductive analysis was organized by the Framework method, and theory-driven themes were identified according to the multidimensional adherence model. This included factors across the social and economic, patient, condition, treatment, and healthcare system levels.

Results

The findings in this study indicate systematic challenges in maintaining continuity between primary, secondary, and community care. Aspects related to social and economic context, treatment, and healthcare systems were found to hinder engagement. Identified facilitators to engagement included the participatory role of family, shared lived experience of addiction/recovery, and therapeutic alliance with healthcare providers.

Conclusion

The understanding of these barriers and facilitators from a service user's perspective can bridge the treatment gap for this clinical population. This can provide an opportunity for the implementation of effective interventions and inform the development of policies promoting accessible care. Government and public health bodies have fundamental roles in shifting treatment paradigms in comorbid AUD and ARLD.

背景:改善合并酒精使用障碍(AUD)和酒精相关肝病(ARLD)患者治疗效果的有效干预措施仍是临床未满足的需求。虽然选择戒酒是预防疾病恶化和死亡的基石,但有证据表明,参与支持康复治疗的效果并不理想。本定性调查旨在通过应用世界卫生组织提出的多维依从性模型,了解该临床人群在治疗过程中遇到的障碍和促进因素:从住院临床环境中招募了24名合并有AUD和ARLD的参与者。本研究通过半结构式深度访谈收集数据。采用框架法进行演绎分析,并根据多维依从性模型确定了理论驱动的主题。这包括社会和经济、患者、病情、治疗和医疗系统等各个层面的因素:本研究的结果表明,在保持初级、二级和社区医疗之间的连续性方面存在系统性挑战。研究发现,与社会和经济环境、治疗和医疗保健系统相关的因素阻碍了患者的参与。已确定的促进参与的因素包括家庭的参与作用、共同的成瘾/康复生活经历以及与医疗服务提供者的治疗联盟:结论:从服务使用者的角度了解这些障碍和促进因素,可以弥补这一临床人群的治疗差距。这可以为实施有效的干预措施提供机会,并为制定促进无障碍护理的政策提供信息。政府和公共卫生机构在转变合并症 AUD 和 ARLD 的治疗模式方面发挥着重要作用。
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引用次数: 0
Long-term effects of alcohol-avoidance training: Do changes in approach bias predict who will remain abstinent? 避酒训练的长期效果:方法偏差的变化能预测哪些人将继续戒酒吗?
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-08-27 DOI: 10.1111/acer.15431
Edwin J. Schenkel, Robert Schöneck, Eni S. Becker, Reinout W. Wiers, Johannes Lindenmeyer, Mike Rinck

Background

Patients with alcohol use disorder (AUD) tend to selectively approach alcohol cues in the environment, demonstrating an alcohol-approach bias. Alcohol-approach-bias modification (Alcohol-ApBM) effectively increases abstinence rates in patients with AUD when added to abstinence-focused treatment, but the evidence for its proposed working mechanism (reduction of the alcohol-approach bias) is limited. Moreover, not all patients benefit from Alcohol-ApBM, and previous research did not identify reliable pretreatment predictors of Alcohol-ApBM effectiveness. Therefore, the current study focused on learning processes during the Alcohol-ApBM training itself. Specifically, we examined whether changes in approach-avoidance tendencies over the course of Alcohol-ApBM would predict abstinence after inpatient treatment.

Methods

The training data of 543 AUD patients in Germany (70% male, M = 47.96, SD = 9.08), receiving Alcohol-ApBM training during inpatient treatment, were used to examine whether various aspects of learning during training predicted abstinence 1 year after treatment discharge, both separately and in interaction with potential sociodemographic and clinical moderators of Alcohol-ApBM effectiveness.

Results

Overall, successful learning across six Alcohol-ApBM training sessions was observed; that is, the approach tendency toward alcoholic stimuli was reduced over time. However, none of the examined learning parameters were predictive of abstinence, neither separately nor in combination with clinical or sociodemographic variables.

Conclusions

Previous studies have shown that Alcohol-ApBM is an effective add-on to abstinence-focused treatment for AUD, and this study showed that learning took place during Alcohol-ApBM training. However, specific learning parameters during training did not predict abstinence 1 year after treatment discharge. Therefore, we cannot specify which patients are most likely to benefit from ApBM with regard to abstinence after 1 year.

背景:酒精使用障碍(AUD)患者倾向于选择性地接近环境中的酒精线索,表现出酒精接近偏差。酒精接近偏差修正法(Alcohol-ApBM)在添加到以戒酒为重点的治疗中时,能有效提高 AUD 患者的戒酒率,但其提出的工作机制(减少酒精接近偏差)的证据有限。此外,并非所有患者都能从酒精-促进戒酒治疗中获益,而且之前的研究也未发现酒精-促进戒酒治疗效果的可靠预测因素。因此,本研究重点关注酒精-ApBM 训练本身的学习过程。具体来说,我们研究了在酒精-ApBM训练过程中,接近-回避倾向的变化是否能预测住院治疗后的戒断情况:方法:我们利用德国 543 名 AUD 患者(70% 为男性,M=47.96,SD=9.08)在住院治疗期间接受 Alcohol-ApBM 培训的培训数据,研究了培训期间学习的各个方面是否能预测出院治疗 1 年后的戒断情况,包括单独预测以及与 Alcohol-ApBM 效果的潜在社会人口学和临床调节因素相互作用的情况:结果:总体而言,在六次酒精-ApBM训练中都观察到了成功的学习;也就是说,随着时间的推移,对酒精刺激的接近倾向降低了。然而,无论是单独还是与临床或社会人口变量相结合,所考察的学习参数都不能预测戒酒情况:以往的研究表明,酒精-ApBM 是以戒酒为重点的 AUD 治疗的有效附加疗法。然而,训练期间的特定学习参数并不能预测治疗出院一年后的戒断情况。因此,我们无法明确哪些患者最有可能在一年后的戒酒方面受益于ApBM。
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引用次数: 0
From alcohol and other drug treatment mediator to mechanism to implementation: A systematic review and the cases of self-efficacy, social support, and craving 从酒精和其他药物治疗中介到机制再到实施:系统回顾以及自我效能、社会支持和渴求的案例。
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-08-25 DOI: 10.1111/acer.15411
Stephen A. Maisto, Dezarie Moskal, Madison K. Firkey, Brandon G. Bergman, Brian Borsari, Kevin A. Hallgren, Jon M. Houck, Margo Hurlocker, Brian D. Kiluk, Alexis Kuerbis, Allecia E. Reid, Molly Magill

Research designed to establish alcohol and other drug (AOD) mechanisms of behavioral change (MOBC) has centered on what variables mediate the relation between AOD treatment and outcomes. The purpose of this paper was to review this research evidence to identify empirically supported mediators of alcohol and other drug use and related outcomes and then to evaluate their potential as being AOD treatment MOBC. The first phase was a systematic review of reviews (2008–2023) to identify the variables with the strongest empirical support as mediators of AOD treatment effects. Eligible reviews focused on AOD treatment modalities, included empirically tested mediators, and targeted adult samples. The second phase was a systematic review of empirical studies (1990–2023) testing the hypothesis that variables identified in phase one were AOD treatment mediators/mechanisms and then evaluating each eligible stage two study according to the Kazdin and Nock (Journal of Child Psychology and Psychiatry, 44, 1116) criteria. Eligible articles included empirical studies with adult samples attending AOD treatment and empirically tested one of the three treatment mechanisms as a mediator of an AOD-related outcome. Databases were searched in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. This systematic review was not preregistered. The first review of 11 eligible review articles identified self-efficacy, social support, and craving as having the strongest empirical support. The second review captured 48 individual studies. An evaluation of each of these studies by the Kazdin and Nock criteria suggested that they likely are MOBC and therefore are ready for implementation. The implementation of self-efficacy, social support, and craving into clinical practice and training is warranted. Six directions for future research to solidify and generalize empirical support for the case that self-efficacy, social support, and craving are MOBC are presented, as are five implications for clinical practice and training.

旨在建立酒精和其他药物(AOD)行为改变机制(MOBC)的研究主要集中在哪些变量可以调节 AOD 治疗与结果之间的关系。本文旨在回顾这些研究证据,找出酒精和其他药物使用及相关结果的经验支持中介因素,然后评估它们作为 AOD 治疗 MOBC 的潜力。第一阶段是对综述(2008-2023 年)进行系统性回顾,以确定哪些变量作为 AOD 治疗效果的中介变量具有最有力的经验支持。符合条件的综述侧重于 AOD 治疗模式,包括经过经验检验的中介变量,并以成人样本为对象。第二阶段是对实证研究(1990-2023 年)进行系统回顾,检验第一阶段确定的变量是否为 AOD 治疗中介/机制的假设,然后根据 Kazdin 和 Nock(《儿童心理学和精神病学杂志》,44, 1116)的标准对符合条件的第二阶段研究进行评估。符合条件的文章包括对接受 AOD 治疗的成人样本进行的实证研究,并对三种治疗机制中的一种作为 AOD 相关结果的中介因素进行了实证测试。根据《系统综述和元分析首选报告项目》对数据库进行了检索。本系统综述未经预先登记。对 11 篇符合条件的综述文章进行了第一次综述,发现自我效能感、社会支持和渴望得到了最有力的经验支持。第二次审查收集了 48 项单独研究。根据卡兹丁和诺克标准对这些研究逐一进行评估后发现,它们很可能是 MOBC,因此可以实施。在临床实践和培训中实施自我效能感、社会支持和渴求是有必要的。本文提出了未来研究的六个方向,以巩固和推广对自我效能、社会支持和渴求是 MOBC 这一论点的经验支持,以及对临床实践和培训的五点启示。
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引用次数: 0
Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence 戒酒早期纹状体末端床核网络对不可预测威胁的反应
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-08-24 DOI: 10.1111/acer.15407
Nicole L. Zabik, Elizabeth A. Flook, Brandee Feola, Margaret M. Benningfield, Marisa M. Silveri, Danny G. Winder, Jennifer Urbano Blackford

Background

Anxiety during early alcohol abstinence, likely resulting from neural changes caused by chronic alcohol use, contributes to high relapse rates. Studies in rodents show heightened activation during early abstinence in the bed nucleus of the stria terminalis (BNST)—a neural hub for anxiety—and its extended anxiety-related corticolimbic network. Despite the clinical importance of early abstinence, few studies investigate the underlying neural mechanisms.

Methods

To address this gap, we investigated brain function in early alcohol abstinence (EA = 20, 9 women) relative to controls (HC = 20, 11 women) using an unpredictable threat task shown to engage the BNST and corticolimbic brain regions involved in anxiety and alcohol use disorder (AUD). Group, anxiety, and sex were predictors used to determine whole-brain activation and BNST functional connectivity.

Results

We found widespread interactions of group × anxiety and group × anxiety × sex for both activation and BNST connectivity during unpredictable threat. In the EA group, higher anxiety was correlated with activation in the BNST, rostral anterior cingulate cortex (ACC), insula (men only), and dorsal ACC (men only). In the HC group, higher anxiety was negatively correlated with activation in the BNST, nucleus accumbens, thalamus, and insula (men only). For connectivity, anxiety was positively correlated in EA and negatively correlated in HC, between the BNST and the amygdala, ventromedial prefrontal cortex (PFC), and dorsomedial PFC; EA men showed stronger BNST-vmPFC connectivity than HC men.

Conclusions

These novel findings provide preliminary evidence for alterations in the BNST and anxiety-related corticolimbic brain regions in early alcohol abstinence, adding to growing literature in humans supporting the BNST's role in anxiety and sex-dependent effects of chronic alcohol use.

背景:早期戒酒期间的焦虑可能是由长期饮酒引起的神经变化造成的,这也是导致高复发率的原因之一。对啮齿类动物的研究表明,在早期戒酒期间,作为焦虑神经中枢的纹状体末端床核(BNST)及其扩展的焦虑相关皮质边缘网络的激活增强。尽管早期戒断具有重要的临床意义,但很少有研究调查其潜在的神经机制:为了填补这一空白,我们利用一项不可预测的威胁任务,研究了早期戒酒者(EA = 20 人,9 名女性)相对于对照组(HC = 20 人,11 名女性)的大脑功能,该任务显示了 BNST 和皮质边缘脑区参与焦虑和酒精使用障碍(AUD)。组别、焦虑和性别是用于确定全脑激活和 BNST 功能连接的预测因子:结果:我们发现,在不可预测的威胁下,组别×焦虑和组别×焦虑×性别对激活和 BNST 连接具有广泛的交互作用。在 EA 组,较高的焦虑与 BNST、喙状前扣带回皮层 (ACC)、脑岛(仅男性)和背侧 ACC(仅男性)的激活相关。在高危人群组中,较高的焦虑与 BNST、伏隔核、丘脑和脑岛(仅男性)的激活呈负相关。在连通性方面,EA 组的焦虑与 BNST 和杏仁核、腹外侧前额叶皮层 (PFC) 以及背内侧前额叶皮层之间呈正相关,而 HC 组则呈负相关;EA 组男性比 HC 组男性表现出更强的 BNST-vmPFC 连通性:这些新发现提供了初步证据,证明在早期戒酒过程中,BNST和焦虑相关的皮质边缘脑区发生了改变,为越来越多的人类文献支持BNST在焦虑和长期饮酒的性别依赖效应中的作用增添了新的内容。
{"title":"Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence","authors":"Nicole L. Zabik,&nbsp;Elizabeth A. Flook,&nbsp;Brandee Feola,&nbsp;Margaret M. Benningfield,&nbsp;Marisa M. Silveri,&nbsp;Danny G. Winder,&nbsp;Jennifer Urbano Blackford","doi":"10.1111/acer.15407","DOIUrl":"10.1111/acer.15407","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Anxiety during early alcohol abstinence, likely resulting from neural changes caused by chronic alcohol use, contributes to high relapse rates. Studies in rodents show heightened activation during early abstinence in the bed nucleus of the stria terminalis (BNST)—a neural hub for anxiety—and its extended anxiety-related corticolimbic network. Despite the clinical importance of early abstinence, few studies investigate the underlying neural mechanisms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To address this gap, we investigated brain function in early alcohol abstinence (EA = 20, 9 women) relative to controls (HC = 20, 11 women) using an unpredictable threat task shown to engage the BNST and corticolimbic brain regions involved in anxiety and alcohol use disorder (AUD). Group, anxiety, and sex were predictors used to determine whole-brain activation and BNST functional connectivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found widespread interactions of group × anxiety and group × anxiety × sex for both activation and BNST connectivity during unpredictable threat. In the EA group, higher anxiety was correlated with activation in the BNST, rostral anterior cingulate cortex (ACC), insula (men only), and dorsal ACC (men only). In the HC group, higher anxiety was negatively correlated with activation in the BNST, nucleus accumbens, thalamus, and insula (men only). For connectivity, anxiety was positively correlated in EA and negatively correlated in HC, between the BNST and the amygdala, ventromedial prefrontal cortex (PFC), and dorsomedial PFC; EA men showed stronger BNST-vmPFC connectivity than HC men.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These novel findings provide preliminary evidence for alterations in the BNST and anxiety-related corticolimbic brain regions in early alcohol abstinence, adding to growing literature in humans supporting the BNST's role in anxiety and sex-dependent effects of chronic alcohol use.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"48 9","pages":"1716-1727"},"PeriodicalIF":3.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.15407","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BNST GluN2D-containing NMDARs contribute to ethanol intake but not negative affective behaviors in female mice BNST 含 GluN2D 的 NMDARs 会导致雌性小鼠摄入乙醇,但不会导致其产生负面情绪行为。
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-08-23 DOI: 10.1111/acer.15432
Marie A. Doyle, Gregory J. Salimando, Megan E. Altemus, Justin K. Badt, Michelle N. Bedenbaugh, Alexander S. Vardy, Danielle N. Adank, Anika S. Park, Danny G. Winder

Background

Alcohol use disorder (AUD) is a chronic, relapsing disease, highly comorbid with anxiety and depression. The bed nucleus of the stria terminalis (BNST) and Crh+ neurons in this region play a key role in chronic ethanol-induced increases in volitional intake, hypothesized to be driven by emergent negative affective behaviors. Excitatory N-methyl-d-aspartate receptors (NMDARs) are a major target of ethanol, and chronic ethanol exposure has been shown to regulate NMDAR function and expression. Specifically, GluN2D subunit-containing NMDARs have emerged as a target of interest due to their limited distribution and potential roles in affective behavior.

Methods

Male and female mice underwent a home cage chronic drinking forced abstinence model (CDFA) to assess the impact of 1 day or 2 weeks of ethanol abstinence on BNST synaptic transmission and BNST Grin gene expression. Constitutive and conditional BNST GluN2D knockout mice were used to assess the impact of GluN2D deletion on continuous access ethanol intake as well as negative affect behaviors, using the open field, elevated zero maze, and forced swim tasks.

Results

We report here that excitatory transmission undergoes time-dependent upregulation in BNST Crh+ cells. Further, knockdown of dorsal BNST (dBNST) GluN2D expression significantly decreases ethanol intake in female, but not male, mice. While BNST Grin2b expression was significantly increased in protracted abstinence following CDFA, no differences in Grin2d expression were observed in the dBNST or dBNST Crh+ neurons. Finally, we find that deletion of GluN2D fails to alter negative affect in ethanol-naïve female mice.

Conclusions

These data suggest a role for BNST GluN2D-containing NMDARs in ethanol drinking but not ethanol abstinence, highlighting sex differences and behavioral specificity. Overall, these data further suggest roles for BNST synaptic signaling in volitional ethanol intake that are partially independent of actions on affective behavior.

背景:酒精使用障碍(AUD)是一种慢性、复发性疾病,与焦虑和抑郁高度共存。纹状体末端床核(BNST)和该区域的Crh+神经元在慢性乙醇诱导的意志摄入量增加中起着关键作用,据推测,乙醇诱导的意志摄入量增加是由新出现的负性情感行为驱动的。兴奋性 N-甲基-d-天冬氨酸受体(NMDARs)是乙醇的一个主要靶点,慢性乙醇暴露已被证明能调节 NMDAR 的功能和表达。特别是含 GluN2D 亚基的 NMDARs,由于其有限的分布和在情感行为中的潜在作用,已成为一个受关注的靶点:方法:对雌雄小鼠进行家笼慢性饮酒强迫戒断模型(CDFA),以评估1天或2周的乙醇戒断对BNST突触传递和BNST Grin基因表达的影响。我们利用连续性和条件性BNST GluN2D基因敲除小鼠来评估GluN2D基因缺失对连续摄入乙醇以及负性情绪行为的影响,包括开放场地、高架零迷宫和强迫游泳任务:结果:我们在此报告了兴奋性传递在 BNST Crh+ 细胞中发生的时间依赖性上调。此外,敲除背侧 BNST(dBNST)GluN2D 的表达会显著降低雌性小鼠的乙醇摄入量,而雄性小鼠则不会。虽然 BNST Grin2b 的表达在 CDFA 后的长期戒断中显著增加,但在 dBNST 或 dBNST Crh+ 神经元中并未观察到 Grin2d 表达的差异。最后,我们发现删除 GluN2D 无法改变乙醇成瘾雌性小鼠的负性情绪:这些数据表明,含 BNST GluN2D 的 NMDARs 在乙醇饮酒中发挥作用,但在乙醇戒断中不发挥作用,凸显了性别差异和行为特异性。总之,这些数据进一步表明,BNST 突触信号在乙醇自愿摄入中的作用部分独立于对情感行为的作用。
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引用次数: 0
The impact of COVID-19-related national lockdowns on alcohol-related traffic collisions, injuries, and fatalities in Lithuania 立陶宛与 COVID-19 有关的全国封锁对与酒精有关的交通碰撞、伤亡事故的影响。
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-08-23 DOI: 10.1111/acer.15429
Shannon Lange, Huan Jiang, Laura Miščikienė, Alexander Tran, Mindaugas Štelemėkas, Jürgen Rehm

Background

The national lockdowns that occurred all over the world in response to the Coronavirus Disease 2019 (COVID-19) pandemic have been found to have impacted alcohol use. The aim was to evaluate the impact of COVID-19-related national lockdowns on alcohol-related traffic collisions, injuries, and fatalities in Lithuania.

Methods

Using monthly data from the Lithuanian Road Police Service for January 2004 to December 2022, we performed interrupted time-series analyses using a generalized additive model to evaluate the impact of COVID-19-related national lockdowns on alcohol-related traffic collisions, injuries, and fatalities. In Lithuania, the COVID-19-related lockdowns occurred from March 2020 to June 2020 and from November 2020 to June 2021.

Results

Although overall rates for traffic collisions and injuries decreased during the COVID-19-related lockdowns in Lithuania, these lockdowns were associated with a 3.21% (95% CI: 1.19%, 5.23%) increase in the relative proportion of alcohol-related traffic collisions and a 2.46% (95% CI: 0.12%, 4.80%) increase in the relative proportion of alcohol-related traffic injuries. The association between the lockdowns and alcohol-related traffic fatalities was not statistically significant.

Conclusion

The COVID-19-related national lockdowns in Lithuania were associated with a decrease in the overall rate of traffic collisions and injuries, but an increase in the relative proportion of alcohol-related traffic collisions and injuries.

背景:世界各地为应对 2019 年冠状病毒病(COVID-19)大流行而采取的全国封锁措施已被发现对酒精的使用产生了影响。本研究旨在评估与 COVID-19 相关的国家禁酒令对立陶宛与酒精相关的交通碰撞、伤亡事故的影响:利用立陶宛道路警察局提供的 2004 年 1 月至 2022 年 12 月的月度数据,我们使用广义加法模型进行了间断时间序列分析,以评估与 COVID-19 相关的国家禁酒令对与酒精相关的交通碰撞、受伤和死亡事故的影响。立陶宛于 2020 年 3 月至 2020 年 6 月和 2020 年 11 月至 2021 年 6 月实施了与 COVID-19 相关的禁酒令:尽管在立陶宛与 COVID-19 相关的封锁期间,交通碰撞和受伤的总体比率有所下降,但这些封锁与酒精相关的交通碰撞相对比例增加了 3.21%(95% CI:1.19%,5.23%),与酒精相关的交通受伤相对比例增加了 2.46%(95% CI:0.12%,4.80%)。封锁与酒精相关交通死亡事故之间的联系在统计学上并不显著:立陶宛与 COVID-19 相关的全国禁酒令降低了交通碰撞和伤害的总体发生率,但增加了与酒精相关的交通碰撞和伤害的相对比例。
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引用次数: 0
Self-reported alcohol consumption during participation in a text messaging-based online drinking moderation platform 参与基于短信的在线饮酒节制平台期间的自我报告饮酒量。
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-08-23 DOI: 10.1111/acer.15414
Nehal P. Vadhan, Hayley Treloar Padovano, Frederick J. Muench, Svetlana Levak, Nicholas Allen

Background

Many individuals with excessive alcohol consumption desire moderation but do not seek formalized treatment. Commercially available, technology-assisted options are flexible and highly accessible, yet often not empirically validated.

Methods

Individuals desiring alcohol moderation (age 21+) self-selected to use Sunnyside®, a web application with tailored and adaptive text messaging. The evaluable dataset included 46,411 members who completed a baseline assessment, enrolled in the program, and tracked their drinking at least once. An adaptive and customizable weekly plan was generated from typical drinking patterns, goals, and weekly reported progress. Personalized daily messages included reminders for real-time drink tracking, plans, and available interactive messaging with peer coaches. Generalized mixed-effect growth models characterized change in drinks per week and daily drinking for 12 weeks after enrollment. Models allowed for nonlinear change and individual variability across members and weeks.

Results

A majority (64.3%) of members reported typically drinking 7 of 7 days per week at baseline. During tracking, drinks per week decreased most in the initial weeks and slowed thereafter, with an overall 33% reduction in weekly drink counts. More severe alcohol-use patterns and concern over drinking at baseline were associated with greater relative benefit.

Conclusions

Drinking patterns appeared amenable to change during 12 weeks of daily drink tracking with Sunnyside®, a tailored web program to reduce drinking and improve overall wellness. Overall, the findings of this naturalistic study, one of the first of its kind, supplement data from randomized clinical trials and support the use of adaptive, technology-assisted tools for alcohol moderation.

背景:许多过度饮酒者希望节制饮酒,但并不寻求正规治疗。商业上可获得的技术辅助方案非常灵活且易于使用,但往往未经经验验证:方法:希望节制饮酒的个人(21 岁以上)自主选择使用 Sunnyside®,这是一款具有定制和自适应短信功能的网络应用程序。可评估的数据集包括 46,411 名完成基线评估、注册该计划并至少跟踪一次其饮酒情况的成员。根据典型的饮酒模式、目标和每周报告的进展情况,生成了自适应和可定制的每周计划。个性化的每日信息包括实时饮酒跟踪提醒、计划以及与同伴教练的互动信息。广义混合效应增长模型描述了入组后 12 周内每周饮酒量和每日饮酒量的变化。模型考虑了非线性变化以及成员和周之间的个体差异:大多数成员(64.3%)表示,在基线时,他们通常每周 7 天中有 7 天喝酒。在跟踪过程中,每周饮酒量在最初几周下降最多,之后有所减缓,每周饮酒量总体下降了 33%。基线时较严重的饮酒模式和对饮酒的担忧与更大的相对受益相关:结论:在使用阳光®进行为期12周的每日饮酒跟踪期间,饮酒模式似乎可以改变,阳光®是一项量身定制的网络计划,旨在减少饮酒并提高整体健康水平。总之,这项自然研究是同类研究中的首例,其结果补充了随机临床试验的数据,并支持使用适应性技术辅助工具来节制饮酒。
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引用次数: 0
Alcohol and arterial stiffness in middle-aged and older adults: Cross-sectional evidence from the UK Biobank study 酒精与中老年人动脉僵化:来自英国生物库研究的横断面证据。
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-08-20 DOI: 10.1111/acer.15426
Rudolph Schutte, Jufen Zhang, Mahreen Kiran, Graham Ball

Background

The association between arterial stiffness and alcohol consumption is still controversial. We investigated this relationship by performing continuous analysis in men drinking only beer/cider, and women drinking only red wine.

Methods

This cross-sectional study involved participants aged 40–69 years consisting of 9029 men who drank only beer/cider, and 6989 women drinking only red wine. Alcohol consumption was captured by self-reported questionnaire and reported as units per week, where one unit is equal 10 mL pure ethanol. Arterial stiffness index (ASI) was estimated using photoplethysmography.

Results

In men consuming a mean 17.8 (5th and 95th percentiles, 2.6–76.7) units/week, ASI increased by heptiles (sevenths) of alcohol captured from beer/cider consumption and after adjusting for age (9.14, 9.40, 9.51, 9.53, 9.80, 9.80, 10.00 m/s; p-trend < 0.001) and after full adjustment (9.29, 9.46. 9.55, 9.55, 9.73, 9.73, 9.75 m/s; p-trend = 0.013). Similarly, in women consuming a mean 8.1 (1.6–29.3) units/week, ASI increased by heptiles of alcohol captured from red wine consumption and after adjusting for age (8.05, 8.05, 8.05, 8.11, 8.17, 8.30, 8.45 m/s; p-trend = 0.012) and borderline significant after full adjustment (8.05, 8.07, 8.05, 8.07, 8.11, 8.22, 8.43 m/s; p-trend = 0.055). These associations were confirmed in multivariable-adjusted regression analysis in all men, men younger and older than 50 years, and when consuming more than 14 units per week. Similarly, these associations were confirmed in all women, women older than 50 years, and in those consuming more than 14 units per week.

Conclusions

Positive linear relationships exist between arterial stiffness and alcohol, irrespective of whether captured from beer/cider consumption in men or red wine consumption in women. No evidence existed to support the notion that our arteries benefit from any level of alcohol consumption.

背景:动脉僵化与饮酒之间的关系仍存在争议。我们通过对只喝啤酒/苹果酒的男性和只喝红酒的女性进行连续分析来研究这种关系:这项横断面研究的参与者年龄在 40-69 岁之间,包括 9029 名只喝啤酒/苹果酒的男性和 6989 名只喝红酒的女性。酒精消耗量通过自我报告问卷调查获得,以每周为单位进行报告,其中一个单位等于 10 毫升纯乙醇。动脉僵化指数(ASI)通过光电血压计进行估算:结果:在平均每周摄入 17.8 单位(第 5 和第 95 百分位数,2.6-76.7)酒精的男性中,ASI 按啤酒/苹果酒酒精摄入量的七分位数(七分位数)和年龄调整后增加(9.14、9.40、9.51、9.53、9.80、9.80、10.00 m/s;p-趋势):动脉僵化与酒精之间存在正线性关系,不管是男性饮用啤酒/苹果酒还是女性饮用红酒。没有证据支持我们的动脉从任何程度的饮酒中获益的观点。
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引用次数: 0
Recovery from alcohol use disorder: Reinforcer pathology theory, measurement, and methods 酒精使用障碍的康复:强化剂病理学理论、测量和方法。
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-08-18 DOI: 10.1111/acer.15406
Warren K. Bickel, Katie Witkiewitz, Liqa N. Athamneh, Alena Kuhlemeier

Recovery from alcohol use disorder (AUD) is a dynamic process that often entails periods of drinking but has been defined primarily by abstinence. Recently, a broader interpretation of recovery was developed, including meeting the Diagnostic and Statistical Manual of Mental Disorders (DSM) remission criteria and improved psychosocial functioning. This new understanding of recovery has facilitated the development of novel theories and methodologies. This paper reviews a new theoretical perspective of recovery, Reinforcer Pathology, and two novel methodological approaches in light of this broader view of recovery. Using this theoretical framework as a foundation, we propose an alternative perspective to explain the recovery process as it relates to environmental factors and valuation of the future; we suggest that changing the environment in which substances are available (e.g., increasing non-alcohol-related activities) and extending one's temporal window are associated with improved recovery outcomes (e.g., remission and quality of life). In this review, we discuss two novel methodological approaches. The first uses latent profile analysis to show that using a measure of Relative Reinforcement Value of Alcohol-Free Activities is associated with a greater likelihood of belonging to a high functioning/infrequent heavy drinking recovery profile. The second developed an online national sample and used an accelerated longitudinal design to study longer-term recovery of up to 12 years over a 5-year study period. Reinforcer Pathology theory, novel methods, and measures may further our understanding of recovery and begin to address critical questions for future studies. Subsequent randomized clinical trials should examine whether the suggested targets and interventions based on the theoretical model improve recovery outcomes prospectively. Measuring and promoting alcohol-free activity engagement may facilitate improved recovery outcomes, while novel methodologies permit an understanding of returning to use or remission across different recovery durations.

酒精使用障碍(AUD)的康复是一个动态的过程,通常需要一段时间的饮酒,但主要以戒酒来定义。最近,人们对康复有了更广泛的解释,包括达到《精神障碍诊断与统计手册》(DSM)的缓解标准和改善社会心理功能。这种对康复的新理解促进了新理论和新方法的发展。本文回顾了康复的一个新理论视角--强化者病理学,以及根据这一更广泛的康复视角提出的两种新方法。以这一理论框架为基础,我们提出了另一种视角来解释与环境因素和对未来的评价有关的康复过程;我们认为,改变可获得物质的环境(如增加与酒精无关的活动)和延长一个人的时间窗口与改善康复结果(如病情缓解和生活质量)有关。在本综述中,我们将讨论两种新颖的方法。第一种方法使用潜在特征分析表明,使用 "无酒精活动的相对强化价值 "衡量标准与更有可能属于 "高功能/不经常大量饮酒康复特征 "相关。第二项研究开发了一个在线全国样本,并采用加速纵向设计来研究在 5 年研究期内长达 12 年的长期恢复情况。强化者病理学理论、新方法和测量方法可以进一步加深我们对康复的理解,并开始解决未来研究的关键问题。随后的随机临床试验应检查基于该理论模型的建议目标和干预措施是否能改善康复效果。衡量和促进无酒精活动的参与可能有助于改善康复结果,而新的方法则有助于了解在不同的康复持续时间内恢复饮酒或病情缓解的情况。
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引用次数: 0
Phosphatidylethanol is a promising tool for screening alcohol consumption during pregnancy 磷脂酰乙醇是筛查孕期饮酒的一种很有前景的工具。
IF 3 Q2 SUBSTANCE ABUSE Pub Date : 2024-08-15 DOI: 10.1111/acer.15418
Margareeta Häkkinen, Anne Arponen, Antti Jylhä, Kati Sulin, Teemu Gunnar

Background

Prenatal alcohol exposure (PAE) is one of the leading causes of preventable developmental disabilities. A lack of objective screening methods results in an under-recognition of the phenomenon. Phosphatidylethanol (PEth) is a specific ethanol biomarker that reveals alcohol intake up to several weeks after alcohol use. So far, PEth has mostly been a tool for detecting moderate and heavy drinking. With lower PEth cut-offs, revealing even minor prenatal alcohol consumption is possible. We aimed to find out if a sensitive method for PEth analysis would give additional information about PAE and to assess the cut-off value for a positive alcohol result in prenatal screening.

Methods

The study was an observational study of 3000 anonymous blood samples collected from the Helsinki University Hospital Diagnostic Center between June and September 2023. The Finnish Red Cross Blood Service received the samples originally for blood group typing and antibody screening as part of the prenatal blood screening program. We developed a sensitive PEth 16:0/18:1 analysis method using ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) equipment after liquid–liquid extraction of PEth from whole blood. The lower limit of quantification was 1 ng/mL.

Results

PEth was ≥2 ng/mL in 5.2% of the cases, ≥8 ng/mL in 2.0%, and ≥20 ng/mL in 1.0%. The detection time of PEth can be several weeks, especially with low PEth concentrations and after heavy alcohol consumption. It remained unknown whether the positive PEth tests resulted from drinking deliberately during pregnancy or before pregnancy recognition.

Conclusions

We suggest adding PEth 16:0/18:1 to a routine prenatal blood screening program with a cut-off of 2 ng/mL—and in positive cases, clinical evaluation and retesting in 2–4 weeks. In clinical settings, information on gestational week and alcohol consumption before pregnancy is relevant and needs to be considered when interpreting low PEth concentrations.

背景:产前酒精暴露(PAE)是导致可预防的发育障碍的主要原因之一。由于缺乏客观的筛查方法,人们对这一现象的认识不足。磷脂酰乙醇(PEth)是一种特异性乙醇生物标志物,可在饮酒后数周内显示酒精摄入量。迄今为止,PEth 主要用于检测中度和重度饮酒。如果 PEth 的临界值较低,那么即使是轻微的产前饮酒也有可能被发现。我们的目的是找出一种敏感的 PEth 分析方法是否能提供 PAE 的额外信息,并评估产前筛查中酒精检测结果呈阳性的临界值:本研究是一项观察性研究,研究对象是 2023 年 6 月至 9 月期间从赫尔辛基大学医院诊断中心采集的 3000 份匿名血液样本。作为产前血液筛查项目的一部分,芬兰红十字会血液服务机构接收这些样本的初衷是进行血型配型和抗体筛查。我们使用超高效液相色谱-串联质谱(UHPLC-MS/MS)设备从全血中提取 PEth 后,开发了一种灵敏的 PEth 16:0/18:1 分析方法。定量下限为 1 ng/mL:结果:5.2%的病例 PEth ≥2 ng/mL,2.0%的病例 PEth ≥8 ng/mL,1.0%的病例 PEth ≥20 ng/mL。PEth 的检测时间可能长达数周,尤其是 PEth 浓度较低和大量饮酒后。目前仍不清楚 PEth 检测呈阳性的原因是怀孕期间故意饮酒还是在妊娠确认前饮酒:我们建议在常规产前血液筛查项目中加入 PEth 16:0/18:1,以 2 纳克/毫升为临界值。在临床环境中,妊娠周数和孕前饮酒量是相关信息,在解释低浓度 PEth 时需要加以考虑。
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引用次数: 0
期刊
Alcohol (Hanover, York County, Pa.)
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