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A Structural Constitutive Model for Planar Collagenous Tissues That Integrates SALS-Derived Fiber Orientation Data 平面胶原组织的结构本构模型,整合了sals衍生的纤维取向数据
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23065
M. Sacks
Structurally based constitutive models attempt to exploit the tissue composition and structure to avoid ambiguities in material characterization, and offer insight into the function, structure, and mechanics of tissue components. In the structural approach, the tissues total strain energy is assumed to be the sum of the individual fiber strain energies [1–3]. Although theoretically complete, the fiber architecture must be estimated from assumed distributions and “backed-out” from the mechanical data. Thus, fall realization of the structural approach is significantly limited without direct quantitative structural information to either validate structural model predictions or for direct implementation into the model. This limitation of the structural constitutive modeling approach motivated the development of the following structural constitutive model for planar collagenous tissue that directly incorporates the experimentally measured angular distribution of collagen fibers.
基于结构的本构模型试图利用组织组成和结构来避免材料表征中的歧义,并提供对组织成分的功能,结构和力学的见解。在结构方法中,组织总应变能被假设为单个纤维应变能的总和[1-3]。虽然理论上是完整的,但必须从假设的分布中估计光纤结构,并从力学数据中“退出”。因此,如果没有直接的定量结构信息来验证结构模型预测或直接实施到模型中,结构方法的实现将受到严重限制。结构本构建模方法的这一局限性促使了平面胶原组织结构本构模型的发展,该模型直接结合了实验测量的胶原纤维的角度分布。
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引用次数: 4
Flow Evaluation of a Compliant Coronary Artery Anastomosis Model 顺应性冠状动脉吻合模型的血流评价
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23123
Pedro D. Pedroso, R. Venugopalan, A. Anayiotos
Coronary artery bypass grafting (CABG) is a common surgical procedure for coronary artery diseases or severe stenosis of the coronary arteries. It makes use of a peripheral vein (usually the saphenous vein of the leg) to form a conduit between the aorta and the coronary artery distal to the obstructive lesion. It is rapidly becoming the treatment of choice in cases where the vessel is more than 70% occluded or when angioplasty is not possible. However, a significant number of grafts subsequently fail due to acute thrombosis in the early post-operative period or to restenosis within months or years. Intimal thickening in the CABG anastomosis has been implicated as the major cause of restenosis and long-term graft failure. Several studies point to the interplay between non-uniform hemodynamics (including disturbed flows and recirculation zones), wall shear stress, and long particle residence time as possible etiologies. An important feature of the anastomosis geometry, is a bulge that forms at the veno-arterial junction. This sinus forms as a result of the stretching of the thin venous wall when the graft is exposed to aortic pressure conditions. The resultant sinus, and the impedance mismatch of the vein-artery connection, contribute to a complicated region of highly disturbed flow at the divider and may have a primary role in restenosis and final failure of the graft.
冠状动脉旁路移植术(CABG)是治疗冠状动脉疾病或冠状动脉严重狭窄的常用手术方法。它利用外周静脉(通常是腿的隐静脉)在主动脉和远端阻塞病变的冠状动脉之间形成导管。在血管阻塞超过70%或血管成形术不可行的情况下,它迅速成为治疗的选择。然而,大量移植物在术后早期因急性血栓形成或数月或数年内再狭窄而失败。冠状动脉搭桥吻合的内膜增厚已被认为是再狭窄和长期移植失败的主要原因。一些研究指出,不均匀的血流动力学(包括紊乱的流动和再循环区)、壁面剪切应力和长颗粒停留时间之间的相互作用是可能的病因。吻合几何的一个重要特征是在静脉-动脉交界处形成一个凸起。当移植物暴露在主动脉压力条件下时,由于薄静脉壁的拉伸而形成的静脉窦。由此产生的窦,以及静脉-动脉连接的阻抗不匹配,导致了分隔处复杂的血流高度紊乱,可能是再狭窄和移植物最终衰竭的主要原因。
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引用次数: 0
A Material Model for Shortening-Dependent Stiffness of Tracheal Smooth Muscle 气管平滑肌缩短相关刚度的材料模型
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23161
P. A. Sarma, R. Pidaparti, R. Meiss
The objectives of the present study are to develop a material model of a tracheal smooth muscle tissue from experimental data, and to simulate the mechanical response through a three-dimensional nonlinear finite element analysis. The developed material model and simulation models are validated against the experimental data. The results obtained indicate that the approach and the material model developed are useful for describing the length-dependent characteristics of tracheal smooth muscle tissue.
本研究的目的是根据实验数据建立气管平滑肌组织的材料模型,并通过三维非线性有限元分析模拟其力学响应。建立的材料模型和仿真模型与实验数据进行了对比验证。结果表明,所建立的方法和材料模型对描述气管平滑肌组织的长度依赖特性是有用的。
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引用次数: 1
Relationships Between Transfemoral Socket Interface Pressure and Hip Moment of Residual Limb With a 4-Bar Pneumatic Knee During Stance Phase of Gait 步态站立阶段4-Bar气动膝关节残肢髋关节力矩与经股窝界面压力的关系
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23051
Junghwa Hong, J. Ryu, Shin-Ki Kim, M. Mun
For transfemoral amputees, the biomechanical interaction between the stump and the prosthetic socket during stance phase of gait is critically important to achieve normal-like ambulation. It is widely accepted that abnormal socket interface pressure distribution and temporal behavior cause pathology in the stump directly affecting gait of amputees. Therefore, many investigators have studied static and dynamic socket pressure behaviors. The results of the investigations suggested that the pressure changes during gait of transfemoral amputees are closely related to the prosthetic alignment, the socket shape, the stump size, and the residual muscle activity [1,2]. In addition, the temporal changes of hip moment during ambulation may affect the socket pressure distributions of transfemoral amputees [3,4]. However, relationships between the hip moment and the socket pressure have not been well understood. The purpose of this study is to investigate the relationships between the hip moment and the socket pressure during amputee gait with transfemoral prostheses.
对于经股截肢者,在站立步态阶段,残肢和假肢窝之间的生物力学相互作用对于实现正常行走至关重要。残端异常的窝界面压力分布和颞部行为导致残端病变,直接影响截肢者的步态,已被广泛接受。因此,许多研究者研究了静态和动态套管压力行为。研究结果表明,经股截肢者步态中的压力变化与假体对齐、窝形、残肢大小和残肌活动密切相关[1,2]。此外,行走时髋关节力矩的时间变化可能影响经股截肢者的窝压分布[3,4]。然而,髋部力矩和髋臼压力之间的关系尚未得到很好的理解。本研究的目的是探讨髋关节力矩与经股假体截肢者步态时髋窝压力之间的关系。
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引用次数: 0
Shape Opimization of Femoral Components of an Artificial Hip Prosthesis Using the Three-Dimensional P-Version Finite Element Method 三维p型有限元法优化人工髋关节假体股骨假体的形状
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23012
M. Higa, I. Nishimura, H. Tanino, Y. Mitamura
The three-dimensional shape optimization of cemented total hip arthroplasty (THA) was introduced in this paper. The P-version Finite Element Method (FEM) combined with an optimization procedure was used to minimize the peak stress in the bone cement near the tip of the implant. Six-design variables were used in this study. Each variable represents the dimension of the medial-lateral width and anterior-posterior width of the three levels (proximal, distal and middle) of cross sectional area of the prosthesis. The results of the design optimization showed considerable reduction in stress concentration compared to the initial design that is currently used clinically.
介绍了骨水泥全髋关节置换术(THA)的三维形状优化。采用p型有限元法(FEM)结合优化程序最小化种植体尖端附近骨水泥的峰值应力。本研究使用了6个设计变量。每个变量代表假体横截面积的三个水平(近端、远端和中端)的内外侧宽度和前后宽度的尺寸。设计优化的结果显示,与目前临床使用的初始设计相比,应力集中程度显著降低。
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引用次数: 0
Numerical Simulation and Evaluation of the Reduced-Platen Compression Test for Estimating Cancellous Bone Mechanical Properties in the Rat 估计大鼠松质骨力学性能的减压试验数值模拟与评价
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23030
H. Hogan, Kent D. Harms, H. Sampson
Animal models are utilized in numerous research studies aimed at better understanding skeletal biology, bone biomechanics, and many orthopedic diseases or pathologies. Prominent among these animal models are rodents, most commonly rats and mice. In estimating bone mechanical properties in these animals, cortical bone is routinely assessed by bending one of the long bones such as the femur or tibia, which targets the mid-diaphysis region. Testing specimens of isolated cancellous bone is exceedingly challenging, however, even for the larger rat skeleton. Recognizing the prominence and importance of cancellous bone mechanical properties has led to increased mechanical testing of vertebra and femoral neck specimens in skeletal research employing rats and mice. The specimens in these tests actually consist of a combination of both cortical and cancellous tissue, however. In an attempt to more closely approximate the ideal of isolated cancellous bone specimens a method has been developed recently for testing specimens from the proximal tibia metaphysis and distal femoral metaphysis [1]. In either case, the specimen in this so-called “reduced-platen compression” (RPC) test consists of a section of the metaphysis containing both cortical and cancellous bone. The specimen and test configuration are illustrated schematically in Fig. 1.
为了更好地理解骨骼生物学、骨生物力学和许多骨科疾病或病理,动物模型被用于许多研究中。这些动物模型中最突出的是啮齿动物,最常见的是大鼠和小鼠。在评估这些动物的骨力学特性时,通常通过弯曲长骨(如股骨或胫骨)来评估皮质骨,其目标是骨干中部区域。然而,对分离的松质骨标本进行测试是极具挑战性的,即使是对较大的大鼠骨骼也是如此。认识到松质骨力学特性的突出和重要性,导致在骨骼研究中使用大鼠和小鼠增加了椎体和股骨颈标本的力学测试。然而,这些测试中的标本实际上由皮质组织和松质组织组成。为了更接近分离松质骨标本的理想,最近开发了一种方法来测试胫骨近端干骺端和股骨远端干骺端[1]的标本。在这两种情况下,在这种所谓的“减压”(RPC)试验中,标本由一段包含皮质骨和松质骨的干骺端组成。试件和试验结构如图1所示。
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引用次数: 0
Characterization of Agarose and Alginate Gels for Cell Compression Experiments 琼脂糖和海藻酸盐凝胶在细胞压缩实验中的表征
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23143
J. Srinivasan, N. Mukherjee
Various concentrations of folly hydrated agarose and alginate gel formed into cuboid shapes are tested in unconfined compression with impermeable plattens to determine Young’s modulus at equilibrium (relaxed elastic modulus) of the gel blocks. Repeat testing of a single block was performed to assess intra-test variability in testing conditions and deterioration of the gels during the testing procedure. Variability in material properties of gels formed in a single batch was assessed. The data was compared with values obtained from a search of relevant literature. While general trends in the data were the same (increased modulus for larger concentration gel), large differences in actual values of material properties were noted which could be ascribed to differences in the method and conditions of testing and theoretical models used to obtain material properties. Accurate properties of the gels are needed in gel-cell (cells embedded in gel) compression experiments in order to extract accurate cellular properties. It is concluded that it is necessary to use the gel material properties obtained under the same conditions of testing in order to determine cellular material properties in gel-cell compression experiments.
不同浓度的水合琼脂糖和海藻酸盐凝胶形成了长方体的形状,在无侧限压缩与不渗透平板测试,以确定杨氏模量在平衡(松弛弹性模量)的凝胶块。对单个块进行重复测试,以评估测试条件下测试内的可变性和测试过程中凝胶的劣化。在单一批次形成的凝胶的材料性能的可变性进行了评估。将这些数据与从相关文献中检索得到的值进行比较。虽然数据的一般趋势是相同的(较大浓度凝胶的模量增加),但注意到材料性能的实际值存在很大差异,这可归因于用于获得材料性能的测试方法和条件以及理论模型的差异。在凝胶细胞(包埋在凝胶中的细胞)压缩实验中,为了提取准确的细胞特性,需要准确的凝胶特性。因此,在凝胶-细胞压缩实验中,有必要使用在相同测试条件下获得的凝胶材料性能来确定细胞材料的性能。
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引用次数: 0
Improved Histologic Analysis of Component Distribution and Wall Behavior in Cyanoacrylate-Embolized Vessels 氰基丙烯酸酯栓塞血管中成分分布和管壁行为的改进组织学分析
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23131
W. Calvo, B. Lieber, A. Wakhloo, L. Hopkins
Use of embolic agents is currently an accepted treatment modality among neurointerventional clinicians in order to completely occlude abnormal shunts in the cerebral vasculature known as arteriovenous malformations or AVMs. The first cyanoacrylate polymer recently approved by the US Food and Drug Administration for use in humans is n-butyl 2-cyanoacrylate (NBCA). In order to control the polymerization time of NBCA, as well as to opacify the mixture for angiographic visualization, an iodized poppyseed oil-based contrast agent (Lipiodol) is added to the NBCA. Glacial acetic acid is also used to delay polymerization further by decreasing the pH of the mixture.
栓塞剂的使用是目前神经介入临床医生公认的治疗方式,目的是完全阻断被称为动静脉畸形(AVMs)的脑血管异常分流。美国食品和药物管理局最近批准用于人体的第一种氰基丙烯酸酯聚合物是2-氰基丙烯酸酯正丁酯(NBCA)。为了控制NBCA的聚合时间,同时为了使混合物的血管造影显示不透明,在NBCA中加入了一种碘化的罂粟籽油基造影剂(脂醇)。冰醋酸也被用来通过降低混合物的pH值来进一步延缓聚合。
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引用次数: 0
The Role of Biomechanics in the Modern Biomedical Engineering Undergraduate Curriculum 生物力学在现代生物医学工程本科课程中的作用
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23023
R. Spilker, R. Kamm
During the Summer and Fall of 2000, the Whitaker Foundation engaged the biomedical engineering community in a curriculum assessment and vision exercise that included: collection and posting (www.Whitaker.org) of a curriculum database from departments and programs in bioengineering (note that within this document, bioengineering is understood to be synonymous with biomedical engineering); identification of key curricular topic areas and facilitators for each of these areas; posting of white papers by the facilitators; and a period of community comment. This activity culminated in the Whitaker Educational Summit, held in December 2000, at which representatives of virtually all US bioengineering departments and programs, numerous international participants, and those interested in establishing programs, gathered for a series of lectures and discussions on general topics in the undergraduate bioengineering curriculum, and for focused group discussions in each of the topic areas. Summary comments were prepared at that meeting by professional science writers and published at the Whitaker web site, and a period of comment followed. As facilitators for the area of biomechanics, and representatives of the US National Committee on Biomechanics, we offer a vision of biomechanics in the undergraduate bioengineering curriculum, and a set of recommendations that result from the. Whitaker process.
在2000年的夏季和秋季,惠特克基金会与生物医学工程社区进行了课程评估和愿景练习,其中包括:收集和发布(www.Whitaker.org)来自生物工程部门和项目的课程数据库(注意,在本文件中,生物工程被理解为生物医学工程的同义词);确定关键的课程主题领域和每个领域的促进因素;由主持人张贴白皮书;还有一段时间的社区评论。这一活动在2000年12月举行的惠特克教育峰会上达到高潮,在峰会上,几乎所有美国生物工程部门和项目的代表、众多国际参与者和那些对建立项目感兴趣的人聚集在一起,就本科生物工程课程的一般主题进行了一系列讲座和讨论,并在每个主题领域进行了重点小组讨论。在那次会议上,专业科学作家准备了总结意见,并发表在惠特克网站上,随后是一段时间的评论。作为生物力学领域的推动者,以及美国国家生物力学委员会的代表,我们提供了生物力学在本科生物工程课程中的愿景,以及一套由美国国家生物力学委员会提出的建议。惠特克的过程。
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引用次数: 0
A Device for Driving a Wire or a Drill Precisely in a Given Direction Through a Point Under Closed Sky Conditions 在封闭的天空条件下,沿着给定的方向精确地穿过一点的一种装置
Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23079
G. Danieli, G. Fragomeni, E. Giuzio
The paper presents a new device which allows the precise positioning of a guide through a point and in a given direction, or which can permit to reach a given bone section. Other devices exist mainly addressed to the insertion of a screw in the correct position on endo-medullary nails, but these are usually based on the knowledge of the geometry of the nail, and are therefore made by the maker of the nail. In other instances, often the doctors use trial drilling under fluoroscopy to place a kirshner wire in the required position. The actual device is instead based only on an aiming methodology resting on geometrical considerations. Previous knowledge of the position of such a point and direction, which can be given by a hole belonging to a plate or to an endo-medullary nail or can be part of the patient’s bone structure, is not necessary. This is due to the use of fluoroscopy coupled to the localisation of two aiming planes on whose interception is placed the line of interest. A first instrument developed on this principle found limited clinical success due to the complexity of the first kinematic chain used in the aiming process and to human error. A new version has been designed and is at present under construction, which solves the kinematic problem through a careful choice of a series of constraints enabling the aiming process to be divided in sub processes, thus gradually controlling the final result.
本文提出了一种新的装置,它可以通过一个点和一个给定的方向精确定位一个引导器,或者可以允许到达一个给定的骨部分。其他设备主要用于将螺钉插入到髓内钉的正确位置,但这些设备通常是基于对钉的几何形状的了解,因此由钉的制造者制造。在其他情况下,医生通常在透视下使用试验钻孔将克氏针放置在所需位置。而实际的装置仅仅基于基于几何考虑的瞄准方法。这一点的位置和方向,可以通过属于钢板或髓内钉的孔来给出,也可以是患者骨结构的一部分,以前的知识是没有必要的。这是由于使用了透视镜,结合了两个瞄准平面的定位,在两个瞄准平面上放置了感兴趣的线。由于瞄准过程中使用的第一个运动链的复杂性和人为错误,根据这一原理开发的第一个仪器在临床上的成功有限。一个新的版本已经设计并正在建造中,它通过仔细选择一系列约束来解决运动学问题,使瞄准过程划分为子过程,从而逐步控制最终结果。
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引用次数: 0
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Advances in Bioengineering
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