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Development of Wrist Separated Exoskeleton Socket of Myoelectric Prosthesis Hand for Symbrachydactyly. 开发治疗共济失调的腕分离式外骨骼肌电假手。
IF 10.5 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-07-15 eCollection Date: 2024-01-01 DOI: 10.34133/cbsystems.0141
Yuki Inoue, Yuki Kuroda, Yusuke Yamanoi, Yoshiko Yabuki, Hiroshi Yokoi

In recent years, the functionality of myoelectric prosthetic hands has improved as motors have become smaller and controls have become more advanced. Attempts have been made to reproduce the rotation and flexion of the wrist by adding degrees of freedom to the wrist joint. However, it is still difficult to fully reproduce the functionality of the wrist joint owing to the weight of the prosthesis and size limitations. In this study, we developed a new socket and prosthetic hand control system that does not interfere with the wrist joint motion. This allows individuals with hand defects who previously used prosthetic hands with fixed wrist joints to freely use their remaining wrist functionality. In the pick-and-place experiment, where blocks were moved from higher to lower locations, we confirmed that the proposed system resulted in a lower elbow position compared with the traditional prosthesis, and the number of blocks transported increased. This significantly reduced the compensatory motion of the elbow and improved the user's performance compared with the use of a conventional prosthetic hand. This study demonstrates the usefulness of a new myoelectric prosthetic hand that utilizes the residual functions of people with hand deficiencies, which have not been utilized in the past, and the direction of its development.

近年来,随着电机越来越小,控制装置越来越先进,肌电假手的功能也得到了改善。人们试图通过增加腕关节的自由度来再现腕关节的旋转和弯曲。然而,由于假肢的重量和尺寸限制,仍然很难完全再现腕关节的功能。在这项研究中,我们开发了一种不会干扰腕关节运动的新型插座和假手控制系统。这样,以前使用固定腕关节假手的手部缺损者就可以自由使用剩余的腕关节功能。在将积木从较高位置移至较低位置的拾放实验中,我们证实,与传统假手相比,拟议的系统可使肘部位置更低,而且搬运的积木数量也有所增加。与使用传统假手相比,这大大减少了肘部的代偿运动,提高了使用者的表现。这项研究表明,新型肌电假手可以利用手部缺陷患者的残余功能,这在过去并没有得到利用,它的实用性和发展方向也是值得肯定的。
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引用次数: 0
Biomimetic Peripheral Nerve Stimulation Promotes the Rat Hindlimb Motion Modulation in Stepping: An Experimental Analysis. 仿生外周神经刺激促进大鼠后肢在迈步中的运动调节:实验分析
IF 10.5 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-07-04 eCollection Date: 2024-01-01 DOI: 10.34133/cbsystems.0131
Pengcheng Xi, Qingyu Yao, Yafei Liu, Jiping He, Rongyu Tang, Yiran Lang

Peripheral nerve stimulation is an effective neuromodulation method in patients with lower extremity movement disorders caused by stroke, spinal cord injury, or other diseases. However, most current studies on rehabilitation using sciatic nerve stimulation focus solely on ankle motor regulation through stimulation of common peroneal and tibial nerves. Using the electrical nerve stimulation method, we here achieved muscle control via different sciatic nerve branches to facilitate the regulation of lower limb movements during stepping and standing. A map of relationships between muscles and nerve segments was established to artificially activate specific nerve fibers with the biomimetic stimulation waveform. Then, characteristic curves depicting the relationship between neural electrical stimulation intensity and joint control were established. Finally, by testing the selected stimulation parameters in anesthetized rats, we confirmed that single-cathode extraneural electrical stimulation could activate combined movements to promote lower limb movements. Thus, this method is effective and reliable for use in treatment for improving and rehabilitating lower limb motor dysfunction.

对于因中风、脊髓损伤或其他疾病导致下肢运动障碍的患者来说,周围神经刺激是一种有效的神经调节方法。然而,目前大多数利用坐骨神经刺激进行康复治疗的研究仅侧重于通过刺激腓总神经和胫总神经来调节踝关节运动。在此,我们利用神经电刺激方法,通过不同的坐骨神经分支实现肌肉控制,以促进步态和站立时下肢运动的调节。我们建立了肌肉与神经节段之间的关系图,利用生物模拟刺激波形人为激活特定神经纤维。然后,建立了描述神经电刺激强度与关节控制之间关系的特征曲线。最后,通过在麻醉大鼠体内测试选定的刺激参数,我们证实单阴极硬膜外电刺激可以激活联合运动,从而促进下肢运动。因此,这种方法在改善和康复下肢运动功能障碍的治疗中是有效和可靠的。
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引用次数: 0
Augmented Recognition of Distracted Driving State Based on Electrophysiological Analysis of Brain Network. 基于脑网络电生理分析的分心驾驶状态增强识别。
IF 10.5 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-07-04 eCollection Date: 2024-01-01 DOI: 10.34133/cbsystems.0130
Geqi Qi, Rui Liu, Wei Guan, Ailing Huang

In this study, we propose an electrophysiological analysis-based brain network method for the augmented recognition of different types of distractions during driving. Driver distractions, such as cognitive processing and visual disruptions during driving, lead to distinct alterations in the electroencephalogram (EEG) signals and the extracted brain networks. We designed and conducted a simulated experiment comprising 4 distracted driving subtasks. Three connectivity indices, including both linear and nonlinear synchronization measures, were chosen to construct the brain network. By computing connectivity strengths and topological features, we explored the potential relationship between brain network configurations and states of driver distraction. Statistical analysis of network features indicates substantial differences between normal and distracted states, suggesting a reconfiguration of the brain network under distracted conditions. Different brain network features and their combinations are fed into varied machine learning classifiers to recognize the distracted driving states. The results indicate that XGBoost demonstrates superior adaptability, outperforming other classifiers across all selected network features. For individual networks, features constructed using synchronization likelihood (SL) achieved the highest accuracy in distinguishing between cognitive and visual distraction. The optimal feature set from 3 network combinations achieves an accuracy of 95.1% for binary classification and 88.3% for ternary classification of normal, cognitively distracted, and visually distracted driving states. The proposed method could accomplish the augmented recognition of distracted driving states and may serve as a valuable tool for further optimizing driver assistance systems with distraction control strategies, as well as a reference for future research on the brain-computer interface in autonomous driving.

在这项研究中,我们提出了一种基于电生理分析的脑网络方法,用于增强对驾驶过程中不同类型分心的识别。驾驶员分心,如驾驶过程中的认知处理和视觉干扰,会导致脑电图(EEG)信号和提取的脑网络发生明显变化。我们设计并进行了一项模拟实验,其中包括 4 个分心驾驶子任务。我们选择了三种连通性指数(包括线性和非线性同步测量)来构建大脑网络。通过计算连接强度和拓扑特征,我们探索了大脑网络配置与驾驶员分心状态之间的潜在关系。对网络特征的统计分析表明,正常状态和分心状态之间存在巨大差异,这表明在分心状态下大脑网络发生了重新配置。我们将不同的大脑网络特征及其组合输入不同的机器学习分类器,以识别分心驾驶状态。结果表明,XGBoost 具有出色的适应性,在所有选定的网络特征方面均优于其他分类器。就单个网络而言,使用同步似然法(SL)构建的特征在区分认知分心和视觉分心方面的准确性最高。3 个网络组合的最佳特征集在二元分类中的准确率为 95.1%,在正常、认知分心和视觉分心驾驶状态的三元分类中的准确率为 88.3%。所提出的方法可实现对分心驾驶状态的增强识别,可作为进一步优化具有分心控制策略的驾驶辅助系统的重要工具,并为未来自动驾驶中的脑机接口研究提供参考。
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引用次数: 0
A Survey on 3D Skeleton-Based Action Recognition Using Learning Method. 使用学习方法进行基于 3D 骨架的动作识别研究。
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-05-16 eCollection Date: 2024-01-01 DOI: 10.34133/cbsystems.0100
Bin Ren, Mengyuan Liu, Runwei Ding, Hong Liu

Three-dimensional skeleton-based action recognition (3D SAR) has gained important attention within the computer vision community, owing to the inherent advantages offered by skeleton data. As a result, a plethora of impressive works, including those based on conventional handcrafted features and learned feature extraction methods, have been conducted over the years. However, prior surveys on action recognition have primarily focused on video or red-green-blue (RGB) data-dominated approaches, with limited coverage of reviews related to skeleton data. Furthermore, despite the extensive application of deep learning methods in this field, there has been a notable absence of research that provides an introductory or comprehensive review from the perspective of deep learning architectures. To address these limitations, this survey first underscores the importance of action recognition and emphasizes the significance of 3-dimensional (3D) skeleton data as a valuable modality. Subsequently, we provide a comprehensive introduction to mainstream action recognition techniques based on 4 fundamental deep architectures, i.e., recurrent neural networks, convolutional neural networks, graph convolutional network, and Transformers. All methods with the corresponding architectures are then presented in a data-driven manner with detailed discussion. Finally, we offer insights into the current largest 3D skeleton dataset, NTU-RGB+D, and its new edition, NTU-RGB+D 120, along with an overview of several top-performing algorithms on these datasets. To the best of our knowledge, this research represents the first comprehensive discussion of deep learning-based action recognition using 3D skeleton data.

由于骨架数据所具有的固有优势,基于三维骨架的动作识别(3D SAR)在计算机视觉领域得到了广泛关注。因此,多年来已有大量令人印象深刻的作品问世,其中包括基于传统手工特征和学习特征提取方法的作品。然而,之前关于动作识别的调查主要集中在以视频或红绿蓝(RGB)数据为主的方法上,与骨架数据相关的评论覆盖范围有限。此外,尽管深度学习方法在这一领域得到了广泛应用,但从深度学习架构角度进行介绍或全面评述的研究明显缺乏。为了解决这些局限性,本研究首先强调了动作识别的重要性,并强调了三维(3D)骨骼数据作为一种有价值的模式的意义。随后,我们全面介绍了基于 4 种基本深度架构(即递归神经网络、卷积神经网络、图卷积网络和变形器)的主流动作识别技术。然后,我们以数据驱动的方式介绍了所有采用相应架构的方法,并进行了详细讨论。最后,我们对目前最大的三维骨骼数据集 NTU-RGB+D 及其新版本 NTU-RGB+D 120 进行了深入分析,并概述了在这些数据集上表现最出色的几种算法。据我们所知,这项研究首次全面讨论了使用三维骨骼数据进行基于深度学习的动作识别。
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引用次数: 0
Magnetic Soft Microrobot Design for Cell Grasping and Transportation. 用于细胞抓取和运输的磁性软微型机器人设计
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.34133/cbsystems.0109
Fanghao Wang, Youchao Zhang, Daoyuan Jin, Zhongliang Jiang, Yaqian Liu, Alois Knoll, Huanyu Jiang, Yibin Ying, Mingchuan Zhou

Manipulating cells at a small scale is widely acknowledged as a complex and challenging task, especially when it comes to cell grasping and transportation. Various precise methods have been developed to remotely control the movement of microrobots. However, the manipulation of micro-objects necessitates the use of end-effectors. This paper presents a study on the control of movement and grasping operations of a magnetic microrobot, utilizing only 3 pairs of electromagnetic coils. A specially designed microgripper is employed on the microrobot for efficient cell grasping and transportation. To ensure precise grasping, a bending deformation model of the microgripper is formulated and subsequently validated. To achieve precise and reliable transportation of cells to specific positions, an approach that combines an extended Kalman filter with a model predictive control method is adopted to accomplish the trajectory tracking task. Through experiments, we observe that by applying the proposed control strategy, the mean absolute error of path tracking is found to be less than 0.155 mm. Remarkably, this value accounts for only 1.55% of the microrobot's size, demonstrating the efficacy and accuracy of our control strategy. Furthermore, an experiment involving the grasping and transportation of a zebrafish embryonic cell (diameter: 800 μm) is successfully conducted. The results of this experiment not only validate the precision and effectiveness of the proposed microrobot and its associated models but also highlight its tremendous potential for cell manipulation in vitro and in vivo.

人们普遍认为,在小尺度上操纵细胞是一项复杂而具有挑战性的任务,尤其是在细胞的抓取和运输方面。目前已开发出各种精确方法来远程控制微型机器人的运动。然而,操纵微型物体必须使用末端执行器。本文介绍了一项关于控制磁性微型机器人运动和抓取操作的研究,该机器人仅使用了 3 对电磁线圈。微机器人上采用了专门设计的微型抓取器,以实现高效的细胞抓取和运输。为确保精确抓取,制定了微抓手的弯曲变形模型,并随后进行了验证。为了精确可靠地将细胞运送到特定位置,我们采用了一种结合了扩展卡尔曼滤波器和模型预测控制方法的方法来完成轨迹跟踪任务。通过实验,我们发现应用所提出的控制策略,路径跟踪的平均绝对误差小于 0.155 毫米。值得注意的是,这一数值仅占微机器人体积的 1.55%,这证明了我们的控制策略的有效性和准确性。此外,我们还成功地进行了抓取和运输斑马鱼胚胎细胞(直径:800 微米)的实验。该实验的结果不仅验证了所提出的微型机器人及其相关模型的精确性和有效性,还凸显了其在体外和体内细胞操作方面的巨大潜力。
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引用次数: 0
MonoAux: Fully Exploiting Auxiliary Information and Uncertainty for Monocular 3D Object Detection. MonoAux:充分利用辅助信息和不确定性进行单目三维物体检测
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-03-27 eCollection Date: 2024-01-01 DOI: 10.34133/cbsystems.0097
Zhenglin Li, Wenbo Zheng, Le Yang, Liyan Ma, Yang Zhou, Yan Peng

Monocular 3D object detection plays a pivotal role in autonomous driving, presenting a formidable challenge by requiring the precise localization of 3D objects within a single image, devoid of depth information. Most existing methods in this domain fall short of harnessing the limited information available in monocular 3D detection tasks. They typically provide only a single detection outcome, omitting essential uncertainty analysis and result post-processing during model inference, thus limiting overall model performance. In this paper, we propose a comprehensive framework that maximizes information extraction from monocular images while encompassing diverse depth estimation and incorporating uncertainty analysis. Specifically, we mine additional information intrinsic to the monocular 3D detection task to augment supervision, thereby addressing the information scarcity challenge. Moreover, our framework handles depth estimation by recovering multiple sets of depth values from calculated visual heights. The final depth estimate and 3D confidence are determined through an uncertainty fusion process, effectively reducing inference errors. Furthermore, to address task weight allocation in multi-task training, we present a versatile training strategy tailored to monocular 3D detection. This approach leverages measurement indicators to monitor task progress, adaptively adjusting loss weights for different tasks. Experimental results on the KITTI and Waymo dataset confirm the effectiveness of our approach. The proposed method consistently provides enhanced performance across various difficulty levels compared to the original framework while maintaining real-time efficiency.

单目三维物体检测在自动驾驶中起着举足轻重的作用,它要求在缺乏深度信息的单幅图像中对三维物体进行精确定位,因此是一项艰巨的挑战。该领域的大多数现有方法都无法利用单目三维检测任务中的有限信息。它们通常只提供单一的检测结果,在模型推理过程中忽略了重要的不确定性分析和结果后处理,从而限制了模型的整体性能。在本文中,我们提出了一个综合框架,它能最大限度地从单目图像中提取信息,同时包含多种深度估算和不确定性分析。具体来说,我们挖掘单目三维检测任务的固有额外信息来增强监督,从而解决信息匮乏的难题。此外,我们的框架通过从计算出的视觉高度恢复多组深度值来处理深度估计。通过不确定性融合过程确定最终的深度估计值和三维置信度,从而有效减少推理误差。此外,为了解决多任务训练中的任务权重分配问题,我们提出了一种专为单目三维检测量身定制的多功能训练策略。该方法利用测量指标监控任务进度,针对不同任务自适应调整损失权重。在 KITTI 和 Waymo 数据集上的实验结果证实了我们方法的有效性。与原始框架相比,所提出的方法在保持实时效率的同时,在各种难度下都能持续提供更高的性能。
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引用次数: 0
Rational Design of Bioactive Materials for Bone Hemostasis and Defect Repair. 骨止血及骨缺损修复生物活性材料的合理设计。
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2023-10-11 eCollection Date: 2023-01-01 DOI: 10.34133/cbsystems.0058
Yuqi Gai, Yue Yin, Ling Guan, Shengchang Zhang, Jiatian Chen, Junyuan Yang, Huaijuan Zhou, Jinhua Li

Everyday unnatural events such as trauma, accidents, military conflict, disasters, and even medical malpractice create open wounds and massive blood loss, which can be life-threatening. Fractures and large bone defects are among the most common types of injuries. Traditional treatment methods usually involve rapid hemostasis and wound closure, which are convenient and fast but may result in various complications such as nerve injury, deep infection, vascular injury, and deep hematomas. To address these complications, various studies have been conducted on new materials that can be degraded in the body and reduce inflammation and abscesses in the surgical area. This review presents the latest research progress in biomaterials for bone hemostasis and repair. The mechanisms of bone hemostasis and bone healing are first introduced and then principles for rational design of biomaterials are summarized. After providing representative examples of hemostatic biomaterials for bone repair, future challenges and opportunities in the field are proposed.

日常非自然事件,如创伤、事故、军事冲突、灾难,甚至医疗事故,都会造成开放性伤口和大量失血,这可能危及生命。骨折和大块骨缺损是最常见的损伤类型。传统的治疗方法通常包括快速止血和伤口闭合,方便快捷,但可能导致各种并发症,如神经损伤、深部感染、血管损伤和深部血肿。为了解决这些并发症,已经对可以在体内降解并减少手术区域炎症和脓肿的新材料进行了各种研究。本文综述了骨止血修复生物材料的最新研究进展。首先介绍了骨止血和骨愈合的机理,然后总结了生物材料合理设计的原则。在提供了用于骨修复的止血生物材料的代表性实例后,提出了该领域未来的挑战和机遇。
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引用次数: 1
A Review of Energy Supply for Biomachine Hybrid Robots. 生物机械混合机器人能源供应综述。
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-26 eCollection Date: 2023-01-01 DOI: 10.34133/cbsystems.0053
Zhiyun Ma, Jieliang Zhao, Li Yu, Mengdan Yan, Lulu Liang, Xiangbing Wu, Mengdi Xu, Wenzhong Wang, Shaoze Yan

Biomachine hybrid robots have been proposed for important scenarios, such as wilderness rescue, ecological monitoring, and hazardous area surveying. The energy supply unit used to power the control backpack carried by these robots determines their future development and practical application. Current energy supply devices for control backpacks are mainly chemical batteries. To achieve self-powered devices, researchers have developed solar energy, bioenergy, biothermal energy, and biovibration energy harvesters. This review provides an overview of research in the development of chemical batteries and self-powered devices for biomachine hybrid robots. Various batteries for different biocarriers and the entry points for the design of self-powered devices are outlined in detail. Finally, an overview of the future challenges and possible directions for the development of energy supply devices used to biomachine hybrid robots is provided.

生物机械混合机器人已被提出用于重要场景,如荒野救援、生态监测和危险区域调查。用于为这些机器人携带的控制背包供电的能量供应单元决定了它们未来的发展和实际应用。目前用于控制背包的能量供应装置主要是化学电池。为了实现自供电设备,研究人员开发了太阳能、生物能、生物热能和生物振动能量采集器。本文综述了用于生物机械混合机器人的化学电池和自供电装置的开发研究。详细概述了用于不同生物载体的各种电池以及自供电装置设计的切入点。最后,概述了用于生物机械混合机器人的能量供应装置的未来挑战和可能的发展方向。
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引用次数: 0
Emulation of Brain Metabolic Activities Based on a Dynamically Controllable Optical Phantom. 基于动态可控光体的脑代谢活动仿真
IF 10.5 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-13 eCollection Date: 2023-01-01 DOI: 10.34133/cbsystems.0047
Yuxiang Lin, Cheng Chen, Zhouchen Ma, Nabil Sabor, Yanyan Wei, Tianhong Zhang, Mohamad Sawan, Guoxing Wang, Jian Zhao

This paper presents a dynamic optical phantom for the simulation of metabolic activities in the brain, and a linear equivalent model is built for control voltage versus substance concentration. A solid-solid dynamic optical phantom is realized by using liquid crystal film as a voltage-controlled light intensity regulator on the surface of basic phantom, which uses epoxy resin as matrix material and nanometer carbon powder and titanium dioxide powder as absorption and scattering dopants, respectively. The dynamic phantom could mimic near-infrared spectrum (NIRS) signals with sampling rate up to 10 Hz, and the maximum simulation errors for oxy-hemoglobin and deoxy-hemoglobin concentrations varying in the range of 1 μmol/l are 7.0% and 17.9%, respectively. Compared with similar solid biomimetic phantoms, the adjustable mimic substance concentration range is extended by an order of magnitude, which meets the simulation requirements of most brain NIRS signals.

本文提出了一种用于模拟大脑代谢活动的动态光学幻影,并建立了控制电压与物质浓度的线性等效模型。以环氧树脂为基体材料,纳米碳粉和二氧化钛粉分别作为吸收和散射掺杂剂,利用液晶膜作为压控光强调节器,在基本型光体表面实现了固-固动态光体。动态模体可以模拟近红外光谱信号,采样率高达10 Hz,对氧血红蛋白和脱氧血红蛋白浓度在1 μmol/l范围内变化的最大模拟误差分别为7.0%和17.9%。与同类固体仿生模型相比,可调节的模拟物质浓度范围扩大了一个数量级,满足大多数脑近红外信号的模拟要求。
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引用次数: 0
Integrated Design Fabrication and Control of a Bioinspired Multimaterial Soft Robotic Hand. 生物启发多材料软机械手的集成设计制造与控制
IF 10.5 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2023-08-08 eCollection Date: 2023-01-01 DOI: 10.34133/cbsystems.0051
Samuel Alves, Mihail Babcinschi, Afonso Silva, Diogo Neto, Diogo Fonseca, Pedro Neto

Machines that mimic humans have inspired scientists for centuries. Bioinspired soft robotic hands are a good example of such an endeavor, featuring intrinsic material compliance and continuous motion to deal with uncertainty and adapt to unstructured environments. Recent research led to impactful achievements in functional designs, modeling, fabrication, and control of soft robots. Nevertheless, the full realization of life-like movements is still challenging to achieve, often based on trial-and-error considerations from design to fabrication, consuming time and resources. In this study, a soft robotic hand is proposed, composed of soft actuator cores and an exoskeleton, featuring a multimaterial design aided by finite element analysis (FEA) to define the hand geometry and promote finger's bendability. The actuators are fabricated using molding, and the exoskeleton is 3D-printed in a single step. An ON-OFF controller keeps the set fingers' inner pressures related to specific bending angles, even in the presence of leaks. The FEA numerical results were validated by experimental tests, as well as the ability of the hand to grasp objects with different shapes, weights, and sizes. This integrated solution will make soft robotic hands more available to people, at a reduced cost, avoiding the time-consuming design-fabrication trial-and-error processes.

几个世纪以来,模仿人类的机器一直激励着科学家。受生物启发的软体机器人手就是这种努力的一个很好的例子,它具有内在的材料顺应性和连续运动性,能够应对不确定性并适应非结构化环境。最近的研究在软机器人的功能设计、建模、制造和控制方面取得了具有影响力的成就。然而,要完全实现栩栩如生的动作仍具有挑战性,从设计到制造往往需要反复试验,耗费大量时间和资源。本研究提出了一种软机器人手,由软致动器核心和外骨骼组成,采用多材料设计,并通过有限元分析(FEA)确定手的几何形状,提高手指的可弯曲性。致动器采用模塑工艺制作,外骨骼则采用三维打印工艺一次成型。即使在出现泄漏的情况下,一个开-关控制器也能使设定的手指内压与特定的弯曲角度保持一致。实验测试验证了有限元分析的数值结果,以及手抓取不同形状、重量和尺寸物体的能力。这种集成解决方案将使人们能够以更低的成本获得软机械手,避免了耗时的设计-制造-试错过程。
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引用次数: 0
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