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Graphdiyne-Related Materials in Biomedical Applications and Their Potential in Peripheral Nerve Tissue Engineering 石墨烯相关材料在生物医学中的应用及其在周围神经组织工程中的潜力
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-09-10 DOI: 10.34133/2022/9892526
Xiao Li, Huiquan Jiang, Ning He, Wei-En Yuan, Y. Qian, Y. Ouyang
Graphdiyne (GDY) is a new member of the family of carbon-based nanomaterials with hybridized carbon atoms of sp and sp2, including α, β, γ, and (6,6,12)-GDY, which differ in their percentage of acetylene bonds. The unique structure of GDY provides many attractive features, such as uniformly distributed pores, highly π-conjugated structure, high thermal stability, low toxicity, biodegradability, large specific surface area, tunable electrical conductivity, and remarkable thermal conductivity. Therefore, GDY is widely used in energy storage, catalysis, and energy fields, in addition to biomedical fields, such as biosensing, cancer therapy, drug delivery, radiation protection, and tissue engineering. In this review, we first discuss the synthesis of GDY with different shapes, including nanotubes, nanowires, nanowalls, and nanosheets. Second, we present the research progress in the biomedical field in recent years, along with the biodegradability and biocompatibility of GDY based on the existing literature. Subsequently, we present recent research results on the use of nanomaterials in peripheral nerve regeneration (PNR). Based on the wide application of nanomaterials in PNR and the remarkable properties of GDY, we predict the prospects and current challenges of GDY-based materials for PNR.
石墨烯(GDY)是碳基纳米材料家族中的一个新成员,具有sp和sp2的杂化碳原子,包括α、β、γ和(6,6,12)-GDY,它们在乙炔键中的百分比不同。GDY独特的结构提供了许多吸引人的特征,如均匀分布的孔隙、高度π-共轭的结构、高热稳定性、低毒性、生物降解性、大比表面积、可调的电导率和显著的热导率。因此,GDY广泛应用于储能、催化和能源领域,以及生物医学领域,如生物传感、癌症治疗、药物输送、辐射防护和组织工程。在这篇综述中,我们首先讨论了不同形状的GDY的合成,包括纳米管、纳米线、纳米壁和纳米片。其次,在现有文献的基础上,介绍了近年来生物医学领域的研究进展,以及GDY的生物降解性和生物相容性。随后,我们介绍了纳米材料在外周神经再生(PNR)中的最新研究结果。基于纳米材料在PNR中的广泛应用和GDY的显著性能,我们预测了GDY基材料用于PNR的前景和当前的挑战。
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引用次数: 8
The Inverse Problems for Computational Psychophysiology: Opinions and Insights 计算心理生理学的反问题:观点和见解
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-08-24 DOI: 10.34133/2022/9850248
B. Hu, Kun Qian, Ye Zhang, Jian Shen, B. Schuller
Since a long time, measuring the psychological status of subjects in a quantitative paradigm is a challenging problem in the scientific community. It is known that there is not a direct way to measure the psychological quantities [1], whereas an emerging methodology, i.e., computational psychophysiology (CPP), was introduced [2]. The core idea of CPP is to explore the link between the psychological quantities and the physiological quantities, which the latter ones can be measured via ubiquitous equipment (e.g., a braincomputer interface device). Psychiatric diseases are usually accompanied by abnormal psychological status, which can be objectively quantified by psychophysiological quantities. Evaluating psychiatric diseases is of great significance for mental health. With the fast development of artificial intelligence, big data, wearables, and the internet of things, we can observe successful achievements in finding quantitative methods for evaluating the degree of psychiatric diseases (e.g., depression) under the guidance of CPP. Nevertheless, the underlying mechanisms of these engineering milestones are still “up in the air” [3]. Investigating the fundamentals of CPP is a prerequisite for strengthening our power to extend the knowledge frontiers of mental health and benefit from clinical practice. D. R. Bach et al. proposed the concept of the “psychophysiological inverse problem,” claiming that psychologists use the peripheral physiological quantities to infer psychological quantities [4]. In particular, compared to other domains (e.g., intelligent disease diagnosis), understanding the mechanism of the mind could even benefit the development of novel clinical treatment methods for psychiatric disease. Therefore, the inverse problem tool cannot only facilitate a more personalised and precised medicine but also help discover the inherited characteristics of the psychophysiology. It is reasonable to think that the fundamental mechanism of CPP can be validated and/or interpreted by introducing the methodology of mathematical inverse problems. By the language of mathematical inverse problems [5], the computational psychophysiological problems can be formulated through an abstract equation,
长期以来,用定量范式测量被试的心理状态一直是科学界面临的难题。众所周知,没有一种直接的方法来测量心理量[1],而一种新兴的方法,即计算心理生理学(CPP),被引入[1]。CPP的核心思想是探索心理量和生理量之间的联系,后者可以通过无处不在的设备(如脑机接口设备)来测量。精神疾病通常伴有异常的心理状态,可以用心理生理量客观地量化。精神疾病的评估对心理健康具有重要意义。随着人工智能、大数据、可穿戴设备和物联网的快速发展,在CPP的指导下,我们可以看到精神疾病(如抑郁症)程度的定量评估方法的成功成果。然而,这些工程里程碑的潜在机制仍然“悬而未决”。研究CPP的基本原理是加强我们扩展精神卫生知识前沿和从临床实践中获益的先决条件。d.r.b ach等人提出了“心理生理逆问题”的概念,声称心理学家使用外围生理量来推断心理量[4]。特别是,与其他领域(例如,智能疾病诊断)相比,了解心理机制甚至可能有利于精神疾病的新型临床治疗方法的发展。因此,逆问题工具不仅可以促进更个性化和精确的医学,而且有助于发现心理生理的遗传特征。有理由认为,CPP的基本机制可以通过引入数学逆问题的方法来验证和/或解释。用数学逆问题[5]的语言来说,计算心理生理问题可以用一个抽象的方程来表述,
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引用次数: 2
A Survey on Design, Actuation, Modeling, and Control of Continuum Robot. 连续体机器人的设计、驱动、建模与控制综述
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-07-25 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9754697
Jingyu Zhang, Qin Fang, Pingyu Xiang, Danying Sun, Yanan Xue, Rui Jin, Ke Qiu, Rong Xiong, Yue Wang, Haojian Lu

In this paper, we describe the advances in the design, actuation, modeling, and control field of continuum robots. After decades of pioneering research, many innovative structural design and actuation methods have arisen. Untethered magnetic robots are a good example; its external actuation characteristic allows for miniaturization, and they have gotten a lot of interest from academics. Furthermore, continuum robots with proprioceptive abilities are also studied. In modeling, modeling approaches based on continuum mechanics and geometric shaping hypothesis have made significant progress after years of research. Geometric exact continuum mechanics yields apparent computing efficiency via discrete modeling when combined with numerical analytic methods such that many effective model-based control methods have been realized. In the control, closed-loop and hybrid control methods offer great accuracy and resilience of motion control when combined with sensor feedback information. On the other hand, the advancement of machine learning has made modeling and control of continuum robots easier. The data-driven modeling technique simplifies modeling and improves anti-interference and generalization abilities. This paper discusses the current development and challenges of continuum robots in the above fields and provides prospects for the future.

本文介绍了连续体机器人的设计、驱动、建模和控制等方面的研究进展。经过几十年的开创性研究,出现了许多创新的结构设计和驱动方法。无系绳磁力机器人就是一个很好的例子;它的外部驱动特性允许小型化,他们已经得到了很多学者的兴趣。此外,还研究了具有本体感觉能力的连续体机器人。在建模方面,基于连续介质力学和几何成形假设的建模方法经过多年的研究取得了重大进展。几何精确连续介质力学通过离散建模与数值分析方法相结合具有明显的计算效率,从而实现了许多有效的基于模型的控制方法。在控制中,闭环和混合控制方法结合传感器反馈信息提供了很高的运动控制精度和弹性。另一方面,机器学习的进步使连续体机器人的建模和控制变得更加容易。数据驱动建模技术简化了建模,提高了抗干扰能力和泛化能力。本文讨论了连续统机器人在上述领域的发展现状和面临的挑战,并对未来进行了展望。
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引用次数: 0
Experimental Verification on Steering Flight of Honeybee by Electrical Stimulation. 电刺激控制蜜蜂飞行的实验验证
IF 10.5 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-07-21 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9895837
Li Yu, Jieliang Zhao, Zhiyun Ma, Wenzhong Wang, Shaoze Yan, Yue Jin, Yu Fang

The artificial locomotion control strategy is the fundamental technique to ensure the accomplishment of the preset assignments for cyborg insects. The existing research has recognized that the electrical stimulation applied to the optic lobes was an appropriate flight control strategy for small insects represented by honeybee. This control technique has been confirmed to be effective for honeybee flight initiation and cessation. However, its regulation effect on steering locomotion has not been fully verified. Here, we investigated the steering control effect of honeybee by applying electrical stimulation signals with different duty cycles and frequencies on the unilateral optic lobes and screened the stimulus parameters with the highest response successful rate. Moreover, we confirmed the effectiveness of steering control by verifying the presence of rotation torque on tethered honeybees and the body orientation change of crawling honeybees. Our study will contribute some reliable parameter references to the motion control of cyborg honeybees.

人工运动控制策略是保证机器人昆虫完成预设任务的基本技术。现有研究已经认识到,对以蜜蜂为代表的小昆虫来说,对视叶进行电刺激是一种合适的飞行控制策略。这种控制技术已被证实对蜜蜂飞行的开始和停止是有效的。然而,其对转向运动的调节作用尚未得到充分验证。在这里,我们通过对单侧视叶施加不同占空比和频率的电刺激信号来研究蜜蜂的转向控制效果,并筛选出响应成功率最高的刺激参数。此外,我们通过验证系留蜜蜂的旋转扭矩和爬行蜜蜂的身体方向变化,证实了转向控制的有效性。我们的研究将为半机械人蜜蜂的运动控制提供一些可靠的参数参考。
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引用次数: 0
Recognition of Drivers' Hard and Soft Braking Intentions Based on Hybrid Brain-Computer Interfaces. 基于脑机混合接口的驾驶员硬、软制动意图识别
IF 10.5 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-07-19 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9847652
Jiawei Ju, Aberham Genetu Feleke, Longxi Luo, Xinan Fan

In this paper, we propose simultaneous and sequential hybrid brain-computer interfaces (hBCIs) that incorporate electroencephalography (EEG) and electromyography (EMG) signals to classify drivers' hard braking, soft braking, and normal driving intentions to better assist driving for the first time. The simultaneous hBCIs adopt a feature-level fusion strategy (hBCI-FL) and classifier-level fusion strategies (hBCIs-CL). The sequential hBCIs include the hBCI-SE1, where EEG signals are prioritized to detect hard braking, and hBCI-SE2, where EMG signals are prioritized to detect hard braking. Experimental results show that the proposed hBCI-SE1 with spectral features and the one-vs-rest classification strategy performs best with an average system accuracy of 96.37% among hBCIs. This work is valuable for developing human-centric intelligent assistant driving systems to improve driving safety and driving comfort and promote the application of BCIs.

在本文中,我们提出了同步和顺序混合脑机接口(hBCIs),结合脑电图(EEG)和肌电图(EMG)信号来分类驾驶员的硬制动,软制动和正常驾驶意图,以更好地辅助驾驶。同时hbci采用特征级融合策略(hBCI-FL)和分类器级融合策略(hbci - cl)。顺序hbci包括hBCI-SE1,其中脑电图信号优先检测硬制动,以及hBCI-SE2,其中肌电信号优先检测硬制动。实验结果表明,结合光谱特征和1 -vs-rest分类策略的hBCI-SE1在hbci中表现最好,平均系统准确率为96.37%。该工作对于开发以人为中心的智能辅助驾驶系统,提高驾驶安全性和舒适性,促进脑机接口的应用具有重要价值。
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引用次数: 0
A Manta Ray-Inspired Biosyncretic Robot with Stable Controllability by Dynamic Electric Stimulation.
IF 10.5 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-07-05 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9891380
Chuang Zhang, Yiwei Zhang, Wenxue Wang, Ning Xi, Lianqing Liu

Biosyncretic robots, which are new nature-based robots in addition to bionic robots, that utilize biological materials to realize their core function, have been supposed to further promote the progress in robotics. Actuation as the main operation mechanism relates to the robotic overall performance. Therefore, biosyncretic robots actuated by living biological actuators have attracted increasing attention. However, innovative propelling modes and control methods are still necessary for the further development of controllable motion performance of biosyncretic robots. In this work, a muscle tissue-based biosyncretic swimmer with a manta ray-inspired propelling mode has been developed. What is more, to improve the stable controllability of the biosyncretic swimmer, a dynamic control method based on circularly distributed multiple electrodes (CDME) has been proposed. In this method, the direction of the electric field generated by the CDME could be real-time controlled to be parallel with the actuation tissue of the dynamic swimmer. Therefore, the instability of the tissue actuation induced by the dynamic included angle between the tissue axis and electric field direction could be eliminated. Finally, the biosyncretic robot has demonstrated stable, controllable, and effective swimming, by adjusting the electric stimulation pulse direction, amplitude, and frequency. This work may be beneficial for not only the development of biosyncretic robots but also other related studies including bionic design of soft robots and muscle tissue engineering.

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引用次数: 0
Hydrodynamic Modeling and Parameter Identification of a Bionic Underwater Vehicle: RobDact. 仿生水下机器人的水动力建模与参数辨识:RobDact
IF 10.5 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-05-31 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9806328
Qiyuan Cao, Rui Wang, Tiandong Zhang, Yu Wang, Shuo Wang

In this paper, the hydrodynamic modeling and parameter identification of the RobDact, a bionic underwater vehicle inspired by Dactylopteridae, are carried out based on computational fluid dynamics (CFD) and force measurement experiment. Firstly, the paper briefly describes the RobDact, then establishes the kinematics model and rigid body dynamics model of the RobDact according to the hydrodynamic force and moment equations. Through CFD simulations, the hydrodynamic force of the RobDact at different speeds is obtained, and then, the hydrodynamic model parameters are identified. Furthermore, the measurement platform is developed to obtain the relationship between the thrust generated by the RobDact and the input fluctuation parameters. Finally, by combining the rigid body dynamics model and the fin thrust mapping model, the hydrodynamic model of the RobDact at different motion states is constructed.

本文基于计算流体力学(CFD)和测力实验,对仿生水下机器人RobDact进行了流体动力学建模和参数识别。本文首先简要介绍了RobDact,然后根据水动力方程和力矩方程建立了RobDact的运动学模型和刚体动力学模型。通过CFD模拟,获得了RobDact在不同速度下的流体动力,并确定了流体动力学模型参数。此外,开发了测量平台,以获得RobDact产生的推力与输入波动参数之间的关系。最后,将刚体动力学模型和鳍推力映射模型相结合,建立了RobDact在不同运动状态下的流体动力学模型。
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引用次数: 0
A Cyborg Insect Reveals a Function of a Muscle in Free Flight 半机械昆虫揭示了自由飞行时肌肉的功能
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-05-04 DOI: 10.34133/2022/9780504
T. Vo-Doan, V. T. Dung, Hirotaka Sato
While engineers put lots of effort, resources, and time in building insect scale micro aerial vehicles (MAVs) that fly like insects, insects themselves are the real masters of flight. What if we would use living insect as platform for MAV instead? Here, we reported a flight control via electrical stimulation of a flight muscle of an insect-computer hybrid robot, which is the interface of a mountable wireless backpack controller and a living beetle. The beetle uses indirect flight muscles to drive wing flapping and three major direct flight muscles (basalar, subalar, and third axilliary (3Ax) muscles) to control the kinematics of the wings for flight maneuver. While turning control was already achieved by stimulating basalar and 3Ax muscles, electrical stimulation of subalar muscles resulted in braking and elevation control in flight. We also demonstrated around 20 degrees of contralateral yaw and roll by stimulating individual subalar muscle. Stimulating both subalar muscles lead to an increase of 20 degrees in pitch and decelerate the flight by 1.5 m/s2 as well as an induce in elevation of 2 m/s2.
虽然工程师们投入了大量的精力、资源和时间来制造像昆虫一样飞行的昆虫微型飞行器(MAVs),但昆虫本身才是真正的飞行大师。如果我们用活体昆虫作为MAV的平台呢?在这里,我们报道了通过电刺激昆虫-计算机混合机器人的飞行肌肉来控制飞行,这是一个可安装的无线背包控制器和一只活甲虫的界面。甲虫使用间接飞行肌肉驱动翅膀拍打,三个主要的直接飞行肌肉(基底肌、翼下肌和第三腋肌)控制翅膀的运动以进行飞行机动。虽然已经通过刺激基底肌和3Ax肌实现了转向控制,但在飞行中对翼下肌的电刺激可以实现制动和高度控制。我们还通过刺激个别的颚下肌肉,演示了大约20度的对侧偏航和侧滚。刺激翼下肌肉会导致俯仰增加20度,飞行减速1.5 m/s2,并诱导高度上升2 m/s2。
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引用次数: 6
Design and Dynamic Locomotion Control of Quadruped Robot with Perception-Less Terrain Adaptation 无感知地形适应四足机器人的设计与动态运动控制
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-02-22 DOI: 10.34133/2022/9816495
Lei Wang, Libo Meng, Ru Kang, Botao Liu, Sai Gu, Zhi Zhang, Fei Meng, A. Ming
In this paper, a parallel quadrupedal robot was designed that is capable of versatile dynamic locomotion and perception-less terrain adaptation. Firstly, a quadrupedal robot with a symmetric legs and a powerful actuator was implemented for highly dynamic movement. Then, a fast and reliable method based on generalized least square was proposed for estimating the terrain parameters by fusing the body, leg, and contact information. On the basis of virtual model control (VMC) with the quadratic program (QP) method, the optimal foot force for terrain adaptation was achieved. Finally, the results obtained by simulation and indoor and outdoor experiments demonstrate that the robot can achieve a robust and versatile dynamic locomotion on uneven terrain, and the rejection of disturbances is reliable, which proves the effectiveness and robustness of this proposed method.
本文设计了一种具有多功能动态运动和无感知地形适应能力的并联四足机器人。首先,实现了一个具有对称腿和强大执行器的四足机器人的高动态运动。然后,提出了一种基于广义最小二乘的快速可靠的方法,通过融合身体、腿和接触信息来估计地形参数。在虚拟模型控制(VMC)的基础上,采用二次规划(QP)方法,实现了地形适应的最优足力。最后,仿真和室内外实验结果表明,该机器人能够在不平坦的地形上实现鲁棒、通用的动态运动,并且对干扰的抑制是可靠的,证明了该方法的有效性和鲁棒性。
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引用次数: 17
Magnetically Driven Soft Continuum Microrobot for Intravascular Operations in Microscale 用于微尺度血管内手术的磁驱动软连续体微型机器人
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-02-15 DOI: 10.34133/2022/9850832
Dan Liu, Xiaoming Liu, Zhuo Chen, Zhaofeng Zuo, Xiaoqing Tang, Qiang Huang, T. Arai
Remotely controlled soft continuum robots with active steering capability have broad prospects in medical applications. However, conventional continuum robots have the miniaturization challenge. This paper presents a microscale soft continuum microrobot with steering and locomotion capabilities based on magnetic field actuation. The magnetically driven soft continuum microrobot is made of NdFeB particles and polydimethylsiloxane (PDMS), and it can be as small as 200 μm in diameter. Moreover, a hydrogel layer is covered on the surface of the microrobot, which not only overcomes the adhesion force between the microobjects and the soft tip but also reduces the friction between the microrobot and substrate. The performance test indicates the soft continuum microrobot featured excellent control and steering capabilities. The experimental results demonstrate that the soft continuum microrobot can travel through the microfluidic channel by its own vibration and flexibly steer in a bifurcation environment. Moreover, the micromanipulation of microbeads in the microfluidic channels proves that the proposed microscale soft continuum microrobot has a great potential for intravascular manipulation.
具有主动转向能力的远程控制软连续体机器人在医疗领域有着广阔的应用前景。然而,传统的连续体机器人具有小型化的挑战。本文提出了一种基于磁场驱动的具有转向和运动能力的微型软连续体微型机器人。磁驱动的软连续体微型机器人由钕铁硼颗粒和聚二甲基硅氧烷(PDMS)制成,它可以小到200 μm。此外,在微型机器人的表面覆盖了水凝胶层,这不仅克服了微型物体与软尖端之间的附着力,还减少了微型机器人与基底之间的摩擦。性能测试表明,该柔性连续体微型机器人具有良好的控制和转向能力。实验结果表明,柔性连续体微机器人可以通过自身的振动穿过微流体通道,并在分叉环境中灵活操纵。此外,微流体通道中微珠的微观操作证明了所提出的微尺度软连续体微机器人在血管内操作方面具有巨大的潜力。
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引用次数: 25
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Cyborg and bionic systems (Washington, D.C.)
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