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Multimodal Locomotion and Cargo Transportation of Magnetically Actuated Quadruped Soft Microrobots. 磁驱动四足软微型机器人的多模式运动与货物运输。
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-01-01 DOI: 10.34133/cbsystems.0004
Chenyang Huang, Zhengyu Lai, Xinyu Wu, Tiantian Xu

Untethered microrobots have attracted extensive attention due to their potential for biomedical applications and micromanipulation at the small scale. Soft microrobots are of great research importance because of their highly deformable ability to achieve not only multiple locomotion mechanisms but also minimal invasion to the environment. However, the existing microrobots are still limited in their ability to locomote and cross obstacles in unstructured environments compared to conventional legged robots. Nature provides much inspiration for developing miniature robots. Here, we propose a bionic quadruped soft thin-film microrobot with a nonmagnetic soft body and 4 magnetic flexible legs. The quadruped soft microrobot can achieve multiple controllable locomotion modes in the external magnetic field. The experiment demonstrated the robot's excellent obstacle-crossing ability by walking on the surface with steps and moving in the bottom of a stomach model with gullies. In particular, by controlling the conical angle of the external conical magnetic field, microbeads gripping, transportation, and release of the microrobot were demonstrated. In the future, the quadruped microrobot with excellent obstacle-crossing and gripping capabilities will be relevant for biomedical applications and micromanipulation.

无系绳微型机器人由于其在生物医学应用和小规模微操作方面的潜力而引起了广泛的关注。软体微型机器人具有高度可变形的能力,不仅可以实现多种运动机制,而且对环境的影响最小,因此具有重要的研究意义。然而,与传统的有腿机器人相比,现有的微型机器人在非结构化环境中移动和跨越障碍物的能力仍然有限。大自然为开发微型机器人提供了很多灵感。本文提出了一种具有非磁性软体和4条磁性柔性腿的仿生四足柔性薄膜微型机器人。四足软体微型机器人可以在外加磁场中实现多种可控运动模式。实验通过在有台阶的表面行走和在有沟壑的胃模型底部移动,证明了机器人出色的过障能力。特别地,通过控制外部锥形磁场的锥形角,演示了微型机器人对微珠的抓取、运输和释放。在未来,具有优异的跨障和抓握能力的四足微型机器人将与生物医学应用和微操作相关。
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引用次数: 28
Generalized Pose Decoupled Network for Unsupervised 3D Skeleton Sequence-Based Action Representation Learning. 基于无监督三维骨架序列动作表示学习的广义姿态解耦网络。
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-01-01 DOI: 10.34133/cbsystems.0002
Mengyuan Liu, Fanyang Meng, Yongsheng Liang

Human action representation is derived from the description of human shape and motion. The traditional unsupervised 3-dimensional (3D) human action representation learning method uses a recurrent neural network (RNN)-based autoencoder to reconstruct the input pose sequence and then takes the midlevel feature of the autoencoder as representation. Although RNN can implicitly learn a certain amount of motion information, the extracted representation mainly describes the human shape and is insufficient to describe motion information. Therefore, we first present a handcrafted motion feature called pose flow to guide the reconstruction of the autoencoder, whose midlevel feature is expected to describe motion information. The performance is limited as we observe that actions can be distinctive in either motion direction or motion norm. For example, we can distinguish "sitting down" and "standing up" from motion direction yet distinguish "running" and "jogging" from motion norm. In these cases, it is difficult to learn distinctive features from pose flow where direction and norm are mixed. To this end, we present an explicit pose decoupled flow network (PDF-E) to learn from direction and norm in a multi-task learning framework, where 1 encoder is used to generate representation and 2 decoders are used to generating direction and norm, respectively. Further, we use reconstructing the input pose sequence as an additional constraint and present a generalized PDF network (PDF-G) to learn both motion and shape information, which achieves state-of-the-art performances on large-scale and challenging 3D action recognition datasets including the NTU RGB+D 60 dataset and NTU RGB+D 120 dataset.

人体动作表征来源于对人体形状和动作的描述。传统的无监督三维人体动作表征学习方法采用基于递归神经网络(RNN)的自编码器重构输入姿态序列,然后将自编码器的中级特征作为表征。虽然RNN可以隐式学习一定量的运动信息,但提取的表示主要描述人体形状,不足以描述运动信息。因此,我们首先提出了一个称为姿态流的手工运动特征来指导自编码器的重建,其中级特征被期望描述运动信息。由于我们观察到动作在运动方向或运动规范上可能是独特的,因此性能是有限的。例如,我们可以从运动方向上区分“坐下”和“站起来”,从运动规范上区分“跑步”和“慢跑”。在这种情况下,很难从方向和规范混合的姿势流中学习到独特的特征。为此,我们提出了一种明确的姿态解耦流网络(PDF-E),用于在多任务学习框架中从方向和范数中学习,其中1个编码器用于生成表示,2个解码器分别用于生成方向和范数。此外,我们使用重建输入姿态序列作为附加约束,并提出广义PDF网络(PDF- g)来学习运动和形状信息,该网络在大规模和具有挑战性的3D动作识别数据集(包括NTU RGB+D 60数据集和NTU RGB+D 120数据集)上实现了最先进的性能。
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引用次数: 9
Classification of Soft Tissue Sarcoma Specimens with Raman Spectroscopy as Smart Sensing Technology 拉曼光谱智能传感技术在软组织肉瘤分类中的应用
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2021-12-06 DOI: 10.34133/2021/9816913
Liming Li, Vamiq M. Mustahsan, Guangyu He, F. Tavernier, Gurtej Singh, B. Boyce, F. Khan, I. Kao
Intraoperative confirmation of negative resection margins is an essential component of soft tissue sarcoma surgery. Frozen section examination of samples from the resection bed after excision of sarcomas is the gold standard for intraoperative assessment of margin status. However, it takes time to complete histologic examination of these samples, and the technique does not provide real-time diagnosis in the operating room (OR), which delays completion of the operation. This paper presents a study and development of sensing technology using Raman spectroscopy that could be used for detection and classification of the tumor after resection with negative sarcoma margins in real time. We acquired Raman spectra from samples of sarcoma and surrounding benign muscle, fat, and dermis during surgery and developed (i) a quantitative method (QM) and (ii) a machine learning method (MLM) to assess the spectral patterns and determine if they could accurately identify these tissue types when compared to findings in adjacent H&E-stained frozen sections. High classification accuracy (>85%) was achieved with both methods, indicating that these four types of tissue can be identified using the analytical methodology. A hand-held Raman probe could be employed to further develop the methodology to obtain spectra in the OR to provide real-time in vivo capability for the assessment of sarcoma resection margin status.
术中确认切缘阴性是软组织肉瘤手术的重要组成部分。肉瘤切除后,对切除床上的样本进行冷冻切片检查是术中评估边缘状态的金标准。然而,完成这些样本的组织学检查需要时间,而且该技术不能在手术室(OR)中提供实时诊断,这会延迟手术的完成。本文介绍了一种利用拉曼光谱的传感技术的研究和发展,该技术可用于实时检测和分类切除后肉瘤阴性边缘的肿瘤。我们在手术期间从肉瘤和周围良性肌肉、脂肪和真皮的样本中获得了拉曼光谱,并开发了(i)定量方法(QM)和(ii)机器学习方法(MLM)来评估光谱模式,并确定与相邻H&E染色冷冻切片的结果相比,它们是否能够准确识别这些组织类型。这两种方法都达到了较高的分类准确率(>85%),表明使用分析方法可以识别这四种类型的组织。手持拉曼探针可用于进一步开发在OR中获得光谱的方法,为评估肉瘤切除边缘状态提供实时体内能力。
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引用次数: 4
Application Research on Optimization Algorithm of sEMG Gesture Recognition Based on Light CNN+LSTM Model 基于Light CNN+LSTM模型的表面肌电信号手势识别优化算法应用研究
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2021-11-08 DOI: 10.34133/2021/9794610
Dianchun Bai, Tie Liu, Xinghua Han, Hongyu Yi
The deep learning gesture recognition based on surface electromyography plays an increasingly important role in human-computer interaction. In order to ensure the high accuracy of deep learning in multistate muscle action recognition and ensure that the training model can be applied in the embedded chip with small storage space, this paper presents a feature model construction and optimization method based on multichannel sEMG amplification unit. The feature model is established by using multidimensional sequential sEMG images by combining convolutional neural network and long-term memory network to solve the problem of multistate sEMG signal recognition. The experimental results show that under the same network structure, the sEMG signal with fast Fourier transform and root mean square as feature data processing has a good recognition rate, and the recognition accuracy of complex gestures is 91.40%, with the size of 1 MB. The model can still control the artificial hand accurately when the model is small and the precision is high.
基于表面肌电的深度学习手势识别在人机交互中发挥着越来越重要的作用。为了保证深度学习在多状态肌肉动作识别中的高精度,并确保训练模型能够应用于存储空间较小的嵌入式芯片中,本文提出了一种基于多通道表面肌电放大单元的特征模型构建和优化方法。将卷积神经网络和长期记忆网络相结合,利用多维序列sEMG图像建立特征模型,以解决多状态sEMG信号识别问题。实验结果表明,在相同的网络结构下,采用快速傅立叶变换和均方根作为特征数据处理的sEMG信号具有良好的识别率,复杂手势的识别准确率为91.40%,大小为1 MB。当模型较小且精度较高时,该模型仍然可以精确地控制假手。
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引用次数: 20
Self-Assembly of DNA Molecules: Towards DNA Nanorobots for Biomedical Applications DNA分子的自组装:迈向生物医学应用的DNA纳米机器人
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2021-10-19 DOI: 10.34133/2021/9807520
Yong Hu
DNA nanotechnology takes DNA molecule out of its biological context to build nanostructures that have entered the realm of robots and thus added a dimension to cyborg and bionic systems. Spurred by spring-like properties of DNA molecule, the assembled nanorobots can be tuned to enable restricted, mechanical motion by deliberate design. DNA nanorobots can be programmed with a combination of several unique features, such as tissue penetration, site-targeting, stimuli responsiveness, and cargo-loading, which makes them ideal candidates as biomedical robots for precision medicine. Even though DNA nanorobots are capable of detecting target molecule and determining cell fate via a variety of DNA-based interactions both in vitro and in vivo, major obstacles remain on the path to real-world applications of DNA nanorobots. Control over nanorobot's stability, cargo loading and release, analyte binding, and dynamic switching both independently and simultaneously represents the most eminent challenge that biomedical DNA nanorobots currently face. Meanwhile, scaling up DNA nanorobots with low-cost under CMC and GMP standards represents other pertinent challenges regarding the clinical translation. Nevertheless, DNA nanorobots will undoubtedly be a powerful toolbox to improve human health once those remained challenges are addressed by using a scalable and cost-efficient method.
DNA纳米技术将DNA分子从其生物背景中分离出来,构建纳米结构,这些纳米结构已进入机器人领域,从而为半机械人和仿生系统增加了一个维度。在DNA分子类似弹簧的特性的刺激下,组装的纳米机器人可以通过精心设计来调整,使其能够进行有限的机械运动。DNA纳米机器人可以通过编程结合几个独特的特征,如组织穿透、定位、刺激反应和货物装载,这使它们成为精准医疗生物医学机器人的理想候选人。尽管DNA纳米机器人能够在体外和体内通过多种基于DNA的相互作用检测目标分子并决定细胞命运,但在DNA纳米机器人的实际应用道路上仍然存在主要障碍。控制纳米机器人的稳定性、装载和释放、分析物结合和动态切换是生物医学DNA纳米机器人目前面临的最突出的挑战。同时,在CMC和GMP标准下,以低成本扩大DNA纳米机器人的规模是临床转化的其他相关挑战。然而,DNA纳米机器人无疑将成为改善人类健康的强大工具箱,一旦使用可扩展且经济有效的方法解决这些挑战。
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引用次数: 21
Pt/CNT Micro-Nanorobots Driven by Glucose Catalytic Decomposition 葡萄糖催化分解驱动Pt/CNT微纳米机器人
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2021-08-06 DOI: 10.34133/2021/9876064
Hao Wang, Jiacheng Kan, Xin Zhang, C. Gu, Zhan Yang
Swimming micro-nanorobots have attracted researchers' interest in potential medical applications on target therapy, biosensor, drug carrier, and others. At present, the experimental setting of the swimming micro-nanorobots was mainly studied in pure water or H2O2 solution. This paper presents a micro-nanorobot that applied glucose in human body fluid as driving fuel. Based on the catalytic properties of the anode and cathode materials of the glucose fuel cell, platinum (Pt) and carbon nanotube (CNT) were selected as the anode and cathode materials, respectively, for the micro-nanorobot. The innovative design adopted the method of template electrochemical and chemical vapor deposition to manufacture the Pt/CNT micro-nanorobot structure. Both the scanning electron microscope (SEM) and transmission electron microscope (TEM) were employed to observe the morphology of the sample, and its elements were analyzed by energy-dispersive X-ray spectroscopy (EDX). Through a large number of experiments in a glucose solution and according to Stoker's law of viscous force and Newton's second law, we calculated the driving force of the fabricated micro-nanorobot. It was concluded that the structure of the Pt/CNT micro-nanorobot satisfied the required characteristics of both biocompatibility and motion.
游泳微型纳米机器人吸引了研究人员对靶向治疗、生物传感器、药物载体等潜在医学应用的兴趣。目前,游泳微纳米机器人的实验环境主要是在纯水或H2O2溶液中进行的。本文介绍了一种应用人体体液中葡萄糖作为驱动燃料的微型纳米机器人。基于葡萄糖燃料电池阳极和阴极材料的催化性能,选择铂(Pt)和碳纳米管(CNT)分别作为微型纳米机器人的阳极和阴极。创新设计采用模板电化学和化学气相沉积的方法制备了Pt/CNT微纳米机器人结构。采用扫描电子显微镜(SEM)和透射电子显微镜(TEM)对样品的形貌进行了观察,并用能谱仪(EDX)对其元素进行了分析。通过在葡萄糖溶液中的大量实验,根据斯托克斯粘性力定律和牛顿第二定律,计算了所制造的微纳机器人的驱动力。结果表明,Pt/CNT微纳米机器人的结构满足了生物相容性和运动特性的要求。
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引用次数: 24
Human Somatosensory Processing and Artificial Somatosensation 人体体感觉加工与人工体感觉
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2021-07-02 DOI: 10.34133/2021/9843259
Luyao Wang, Lihua Ma, Jiajia Yang, Jinglong Wu
In the past few years, we have gained a better understanding of the information processing mechanism in the human brain, which has led to advances in artificial intelligence and humanoid robots. However, among the various sensory systems, studying the somatosensory system presents the greatest challenge. Here, we provide a comprehensive review of the human somatosensory system and its corresponding applications in artificial systems. Due to the uniqueness of the human hand in integrating receptor and actuator functions, we focused on the role of the somatosensory system in object recognition and action guidance. First, the low-threshold mechanoreceptors in the human skin and somatotopic organization principles along the ascending pathway, which are fundamental to artificial skin, were summarized. Second, we discuss high-level brain areas, which interacted with each other in the haptic object recognition. Based on this close-loop route, we used prosthetic upper limbs as an example to highlight the importance of somatosensory information. Finally, we present prospective research directions for human haptic perception, which could guide the development of artificial somatosensory systems.
在过去的几年里,我们对人类大脑中的信息处理机制有了更好的了解,这导致了人工智能和人形机器人的进步。然而,在各种感觉系统中,研究体感系统是最大的挑战。在这里,我们对人类体感系统及其在人工系统中的相应应用进行了全面的综述。由于人手在整合受体和致动器功能方面的独特性,我们重点研究了体感系统在物体识别和动作指导中的作用。首先,总结了人工皮肤的基本原理,即人体皮肤中的低阈值机械感受器和沿着上升路径的躯体组织原理。其次,我们讨论了在触觉对象识别中相互作用的高级大脑区域。基于这种闭环路线,我们以假肢上肢为例来强调体感信息的重要性。最后,我们提出了人类触觉感知的前瞻性研究方向,这可以指导人工体感系统的发展。
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引用次数: 21
Application of Interactive Video Games as Rehabilitation Tools to Improve Postural Control and Risk of Falls in Prefrail Older Adults 应用互动视频游戏作为康复工具改善体位控制和老年人跌倒风险
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2021-06-25 DOI: 10.34133/2021/9841342
Hammad Alhasan, P. Wheeler, D. Fong
The purpose of this study was to examine whether interactive video game (IVG) training is an effective way to improve postural control outcomes and decrease the risk of falls. A convenience sample of 12 prefrail older adults were recruited and divided into two groups: intervention group performed IVG training for 40 minutes, twice per week, for a total of 16 sessions. The control group received no intervention and continued their usual activity. Outcome measures were centre of pressure (COP), mean velocity, sway area, and sway path. Secondary outcomes were Berg Balance Scale, Timed Up and Go (TUG), Falls Efficacy Scale International (FES-I), and Activities-Specific Balance Confidence (ABC). Assessment was conducted with preintervention (week zero) and postintervention (week eight). The intervention group showed significant improvement in mean velocity, sway area, Berg Balance Scale, and TUG (p < 0.01) compared to the control group. However, no significant improvement was observed for sway path (p = 0.35), FES-I (p = 0.383), and ABC (p = 0.283). This study showed that IVG training led to significant improvements in postural control but not for risk of falls.
本研究的目的是检验交互式视频游戏(IVG)训练是否能有效改善姿势控制结果和降低跌倒风险。为了方便起见,我们招募了12名体弱多病的老年人作为样本,并将其分为两组:干预组进行IVG训练,每次40分钟,每周两次,共16次。对照组没有接受任何干预,继续他们的日常活动。结果测量为压力中心(COP)、平均速度、摇摆面积和摇摆路径。次要结果是Berg平衡量表、计时起走量表(TUG)、国际跌倒效能量表(FES-I)和活动特定平衡信心量表(ABC)。评估在干预前(第0周)和干预后(第8周)进行。干预组的平均速度、摇摆面积、Berg平衡量表、TUG均较对照组有显著改善(p < 0.01)。然而,在摇摆路径(p = 0.35)、FES-I (p = 0.383)和ABC (p = 0.283)方面没有观察到显著的改善。这项研究表明,IVG训练可以显著改善姿势控制,但不能降低跌倒的风险。
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引用次数: 5
Noninvasive Human-Prosthesis Interfaces for Locomotion Intent Recognition: A Review 用于运动意图识别的无创人-假体接口:综述
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2021-06-04 DOI: 10.34133/2021/9863761
Dongfang Xu, Qining Wang
The lower-limb robotic prostheses can provide assistance for amputees' daily activities by restoring the biomechanical functions of missing limb(s). To set proper control strategies and develop the corresponding controller for robotic prosthesis, a prosthesis user's intent must be acquired in time, which is still a major challenge and has attracted intensive attentions. This work focuses on the robotic prosthesis user's locomotion intent recognition based on the noninvasive sensing methods from the recognition task perspective (locomotion mode recognition, gait event detection, and continuous gait phase estimation) and reviews the state-of-the-art intent recognition techniques in a lower-limb prosthesis scope. The current research status, including recognition approach, progress, challenges, and future prospects in the human's intent recognition, has been reviewed. In particular for the recognition approach, the paper analyzes the recent studies and discusses the role of each element in locomotion intent recognition. This work summarizes the existing research results and problems and contributes a general framework for the intent recognition based on lower-limb prosthesis.
下肢机器人假肢可以通过恢复失去肢体的生物力学功能,为截肢者的日常活动提供帮助。为了制定合适的假肢机器人控制策略和开发相应的控制器,必须及时获取假肢使用者的意图,这仍然是一个重大挑战,并引起了人们的广泛关注。本文从识别任务的角度(运动模式识别、步态事件检测和连续步态相位估计)对基于无创传感方法的机器人义肢使用者的运动意图识别进行了研究,并对目前下肢义肢范围内的最新意图识别技术进行了综述。综述了人类意图识别的研究现状,包括识别方法、进展、挑战和未来展望。特别是在识别方法方面,本文分析了近年来的研究成果,讨论了各要素在动作意图识别中的作用。本文总结了现有的研究成果和存在的问题,提出了基于下肢假肢的意图识别的总体框架。
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引用次数: 21
Origami Folding by Multifingered Hands with Motion Primitives 多指手与运动原语的折纸折叠
Q1 ENGINEERING, BIOMEDICAL Pub Date : 2021-05-30 DOI: 10.34133/2021/9851834
A. Namiki, Shuichi Yokosawa
Origami, a traditional Japanese art, is an example of superior handwork produced by human hands. Achieving such extreme dexterity is one of the goals of robotic technology. In the work described in this paper, we developed a new general-purpose robot system with sufficient capabilities for performing Origami. We decomposed the complex folding motions into simple primitives and generated the overall motion as a combination of these primitives. Also, to measure the paper deformation in real-time, we built an estimator using a physical simulator and a depth camera. As a result, our experimental system achieved consecutive valley folds and a squash fold.
折纸是日本的一种传统艺术,是由人手制作的高级手工作品的一个例子。实现这种极端的灵活性是机器人技术的目标之一。在本文描述的工作中,我们开发了一种新的通用机器人系统,该系统具有足够的折纸能力。我们将复杂的折叠运动分解为简单的基元,并将整体运动生成为这些基元的组合。此外,为了实时测量纸张变形,我们使用物理模拟器和深度相机构建了一个估计器。结果,我们的实验系统实现了连续的山谷褶皱和南瓜褶皱。
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引用次数: 20
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Cyborg and bionic systems (Washington, D.C.)
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