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Food safety (Tokyo, Japan)最新文献

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Monepantel (Veterinary Medicinal Products). Monepantel(兽药产品)
Pub Date : 2020-03-27 eCollection Date: 2020-03-01 DOI: 10.14252/foodsafetyfscj.D-20-00001

FSCJ conducted a risk assessment of monepantel (CAS No.887148-69-8), a parasiticide based on results from various studies. Data on pharmacokinetics (cattle) and residues (cattle) were newly submitted. Negative results were obtained in all genotoxicity and carcinogenicity studies. The no-observed-adverse-effect level (NOAEL) obtained in all studies was 100 ppm (equivalent to 3 mg/kg bw per day for both sexes). In the 52-week chronic toxicity study in dogs, FSCJ specified an ADI for monepantel at 0.03 mg/kg bw per day based on NOAEL of 3 mg/kg bw per day, by applying a safety factor of 100.

FSCJ根据多项研究结果,对杀虫药monepantel (CAS No.887148-69-8)进行了风险评估。新提交了药代动力学(牛)和残留(牛)数据。所有的遗传毒性和致癌性研究结果均为阴性。在所有研究中获得的未观察到的不良反应水平(NOAEL)为100 ppm(相当于男女每天3 mg/kg体重)。在为期52周的犬类慢性毒性研究中,FSCJ在NOAEL为3 mg/kg bw / day的基础上,应用安全系数为100,规定了monepantel的每日推荐摄入量为0.03 mg/kg bw。
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引用次数: 1
Dedication 奉献
Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818219-2.00014-4
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引用次数: 0
Index 指数
Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818219-2.00021-1
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引用次数: 0
Front matter 前页
Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818219-2.00012-0
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引用次数: 0
Foreword 2 前言2
Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818219-2.00020-x
William “Bill” Marler
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引用次数: 0
Selected cases 选定的情况下
Pub Date : 2020-01-01 DOI: 10.4337/9780857939562.00006
Darin S. Detwiler
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引用次数: 0
Copyright 版权
Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818219-2.00013-2
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引用次数: 0
Acknowledgments 致谢
Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818219-2.00017-x
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引用次数: 0
Fosfomycin (Veterinary Medicinal Products): Summary. 磷霉素(兽药产品):综述。
Pub Date : 2019-12-27 eCollection Date: 2019-12-01 DOI: 10.14252/foodsafetyfscj.D-19-00020

The Food Safety Commission of Japan (FSCJ) conducted a risk assessment of fosfomycin (CAS No. 23155-02-4), using documents submitted for the ‟re-examination" of veterinary medicinal products. The data used for the assessment include ADME of fosfomycin Ca, residue of fosfomycin Ca and of fosfomycin Na, acute toxicity of fosfomycin Ca and fosfomycin Na. Data on subacute toxicity, reproductive and developmental toxicity, genotoxicity and microbiological effect are also included. The lowest-observed-adverse-effect level (LOAEL) in these toxicity studies was 175 mg (titer)/kg body weight (bw) per day based on adverse effects including diarrhea, autopsy findings such as erosion, hyperplasia, and exfoliation of glandular stomach mucosa, and histopathological findings such as erosion of the stomach and ileum mucosa observed as adverse effects in the 35-day subacute toxicity study in rats. Fosfomycin was not teratogenic in rats and rabbits. FSCJ considered that fosfomycin is not a genotoxic carcinogen. The toxicological ADI of fosfomycin was established to be 0.175 mg/kg bw per day by applying a safety factor of 1000 based on the LOAEL of 175 mg (titer)/kg bw per day. On the other hand, the microbiological ADI was calculated to be 0.019 mg/kg bw per day, which is lower than the toxicological ADI. Thus, FSCJ established the ADI for fosfomycin as 0.019 mg/kg bw per day.

日本食品安全委员会(FSCJ)利用提交给兽药产品“复核”的文件,对磷霉素(CAS No. 23155-02-4)进行了风险评估。用于评价的数据包括磷霉素Ca的ADME、磷霉素Ca和磷霉素Na的残留、磷霉素Ca和磷霉素Na的急性毒性。亚急性毒性、生殖和发育毒性、遗传毒性和微生物效应的数据也包括在内。在这些毒性研究中,最低观察到的不良反应水平(LOAEL)为每天175 mg(滴度)/kg体重(bw),这是基于在35天的大鼠亚急性毒性研究中观察到的不良反应,包括腹泻、胃粘膜糜烂、增生和腺体脱落等尸检结果,以及胃和回肠粘膜糜烂等组织病理学结果。磷霉素对大鼠和家兔无致畸作用。FSCJ认为磷霉素不是遗传毒性致癌物。基于每日175 mg(滴度)/kg bw的LOAEL,应用安全系数为1000,确定磷霉素的毒理学ADI为0.175 mg/kg bw / day。另一方面,计算出微生物ADI为0.019 mg/kg bw / d,低于毒理学ADI。因此,FSCJ确定磷霉素的每日推荐摄入量为0.019 mg/kg bw / d。
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引用次数: 0
Effect of Citric Acid on Prolonging the Half-life of Dissolved Ozone in Water. 柠檬酸对延长水中溶解臭氧半衰期的影响。
Pub Date : 2019-12-27 eCollection Date: 2019-12-01 DOI: 10.14252/foodsafetyfscj.D-19-00005
Yoshichika Hirahara, Kazuyoshi Iwata, Katsuhiko Nakamuro

To elucidate the effect of citric acid on the stability of dissolved ozone, half-lives of ozone in a citric acid solution was investigated. Prolongation of the half-life of ozone was clearly shown in the presence of citric acid in ozonized water. In the presence of ethylenediaminetetraacetic acid (EDTA), the half-life of ozone was decreased. The addition of various concentrations of citric acid to the EDTA solution, however, reversed the half-life in a concentration-dependent manner. These indicate that citric acid suppresses ozone self-decomposition in water. A citric acid-mediated suppression mechanism of ozone self-decomposition involving hydroxy radical (HO•) was proposed as follows: HO• formed by the radical chain reaction process of ozone is scavenged by a way of abstracting the hydrogen atom bound to a carbon atom located α-position of a carbonyl group. The radical chain reaction of ozone is, thus, suppressed. These findings demonstrate that the addition of citric acid to ozonized water is useful for the stabilization of ozone. This ability may contribute to the application of ozone sterilization in food production processes.

为了阐明柠檬酸对溶解臭氧稳定性的影响,研究了臭氧在柠檬酸溶液中的半衰期。臭氧水中柠檬酸的存在明显延长了臭氧的半衰期。在乙二胺四乙酸(EDTA)存在下,臭氧的半衰期缩短。然而,在EDTA溶液中加入不同浓度的柠檬酸会以浓度依赖的方式逆转半衰期。说明柠檬酸抑制臭氧在水中的自分解。提出了柠檬酸对臭氧自分解羟基自由基(HO•)的抑制机理:臭氧自由基链反应过程中形成的HO•通过抽离羰基α-位碳原子上的氢原子而被清除。因此,臭氧的自由基链式反应被抑制。这些结果表明,在臭氧化水中加入柠檬酸有助于臭氧的稳定。这种能力可能有助于臭氧灭菌在食品生产过程中的应用。
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引用次数: 12
期刊
Food safety (Tokyo, Japan)
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