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An application of natural language processing for hypoglycemic event identification in patients with diabetes mellitus 自然语言处理在糖尿病患者低血糖事件识别中的应用
Pub Date : 2025-01-21 DOI: 10.1016/j.health.2024.100381
J.E. Camacho-Cogollo , Cristhian Felipe Patiño Zambrano , Christian Lochmuller , Claudia C. Colmenares-Mejia , Nicolas Rozo , Mario A. Isaza-Ruget , Paul Rodriguez , Andrés García
The therapeutic goal for diabetes mellitus is to maintain normal blood glucose levels, but in some cases, hypoglycemia may occur as a consequence of treatment. Identifying patients with hypoglycemia is critical to preventing adverse events and mortality. However, hypoglycemic events are often not accurately documented in electronic health records (EHRs). This study presents a retrospective analysis of the EHRs of patients with diabetes mellitus. We hypothesize that text analytics and machine learning can identify possible hypoglycemic incidents from unstructured physician notes in electronic health records. Our analysis applies these techniques using the Python programming language as a tool. It also considers words that describe symptoms related to hypoglycemia. The analysis involves searching physicians' notes for keywords and applying supervised classification methods to 146,542 records. Natural language processing (NLP) and machine learning algorithms are used to identify possible hypoglycemic events and related symptoms in physicians’ notes. A multi-layer perceptron (MLP) model produces the best classification performance among all the models tested in this study, with an obtained accuracy of 0.87. We show that the NLP approach can effectively identify and automate the text-based detection process of potential hypoglycemic events, and can subsequently be used to make informed decisions about potential patient risks.
糖尿病的治疗目标是维持正常的血糖水平,但在某些情况下,治疗后可能出现低血糖。识别低血糖患者对于预防不良事件和死亡率至关重要。然而,低血糖事件通常不能准确地记录在电子健康记录(EHRs)中。本研究对糖尿病患者的电子病历进行回顾性分析。我们假设文本分析和机器学习可以从电子健康记录中的非结构化医生笔记中识别可能的低血糖事件。我们的分析使用Python编程语言作为工具来应用这些技术。它还考虑描述与低血糖相关症状的单词。该分析包括搜索医生笔记中的关键词,并对146,542条记录应用监督分类方法。自然语言处理(NLP)和机器学习算法用于识别医生记录中可能的低血糖事件和相关症状。在本研究测试的所有模型中,多层感知器(MLP)模型的分类性能最好,获得的准确率为0.87。我们表明,NLP方法可以有效地识别和自动化基于文本的潜在低血糖事件检测过程,并随后可用于对潜在的患者风险做出明智的决定。
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引用次数: 0
An automated information extraction model for unstructured discharge letters using large language models and GPT-4 基于大语言模型和GPT-4的非结构化离职信自动信息提取模型
Pub Date : 2025-01-10 DOI: 10.1016/j.health.2024.100378
Robert M. Siepmann , Giulia Baldini , Cynthia S. Schmidt , Daniel Truhn , Gustav Anton Müller-Franzes , Amin Dada , Jens Kleesiek , Felix Nensa , René Hosch
The administrative burden of manually extracting clinical information from discharge letters is a common challenge in healthcare. This study aims to explore the use of Large Language Models (LLMs), specifically Generative Pretrained Transformer 4 (GPT-4) by OpenAI, for automated extraction of diagnoses, medications, and allergies from discharge letters. Data for this study were sourced from two healthcare institutions in Germany, comprising discharge letters for ten patients from each institution. The first experiment is conducted using a standardized prompt for information extraction. However, challenges were encountered, and the prompt was fine-tuned in a second experiment to improve the results. We further tested whether open-source LLMs can achieve similar results. In the first experiment, primary diagnoses were identified with 85% accuracy and secondary diagnoses with 55.8%. Medications and allergies were extracted with 85.9% and 100% accuracy, respectively. The International Classification of Diseases, 10th revision (ICD-10) codes for the identified diagnoses achieved an accuracy of 85% for primary diagnoses and 60.7% for secondary diagnoses. Anatomical Therapeutic Chemical (ATC) codes were identified with an accuracy of 78.8%. On the other hand, open-source LLMs did not provide similar levels of accuracy and could not consistently fill the template. With prompt fine-tuning in the second experiment, the primary diagnoses, secondary diagnoses, and medications could be predicted with 95%, 88.9%, and 92.2% accuracy, respectively. GPT-4 shows excellent potential for automated extraction of crucial diagnostic and medication information from discharge letters, presumably lowering the administrative burden for healthcare professionals and improving patient outcomes.
手动从出院信中提取临床信息的管理负担是医疗保健领域的一个常见挑战。本研究旨在探索使用大型语言模型(llm),特别是OpenAI的生成预训练转换器4 (GPT-4),从出院信中自动提取诊断、药物和过敏。本研究的数据来自德国的两家医疗机构,包括每家机构10名患者的出院信。第一个实验是使用标准化提示进行信息提取。然而,遇到了挑战,在第二次实验中对提示进行了微调,以改善结果。我们进一步测试了开源llm是否可以达到类似的结果。在第一次实验中,原发性诊断的准确率为85%,继发性诊断的准确率为55.8%。药物和过敏反应的提取准确率分别为85.9%和100%。国际疾病分类第10版(ICD-10)对已确定诊断的编码,原发性诊断的准确率为85%,继发性诊断的准确率为60.7%。解剖治疗化学(ATC)编码的识别准确率为78.8%。另一方面,开源法学硕士没有提供类似的准确性,也不能始终如一地填充模板。在第二次实验中,通过及时的微调,初步诊断、二次诊断和药物预测的准确率分别为95%、88.9%和92.2%。GPT-4显示了从出院信中自动提取关键诊断和药物信息的巨大潜力,可能会降低医疗保健专业人员的管理负担,并改善患者的治疗效果。
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引用次数: 0
An optimal control model with sensitivity analysis for COVID-19 transmission using logistic recruitment rate 基于logistic招募率的COVID-19传播最优控制模型及敏感性分析
Pub Date : 2025-01-08 DOI: 10.1016/j.health.2024.100375
Jonner Nainggolan , Moch. Fandi Ansori , Hengki Tasman
This study proposes an optimal control model for COVID-19 spread, incorporating a logistic recruitment rate. The observations show the disease-free equilibrium exists when the population-existing threshold exceeds 1. The stability of equilibrium is determined by the basic reproduction number R0. This implies that equilibrium is stable when R0 is less than or equal to 1, but it is unstable when the value is greater than 1. Furthermore, an endemic equilibrium and stability is recorded when R0 exceeds 1. To identify influential factors in COVID-19 spread, sensitivity index and sensitivity analyses of R0 are conducted. The model perfectly integrates both prevention and therapy controls. As a result, numerical simulations show that the prevention control is more effective than the treatment control in reducing COVID-19 spread. Moreover, the simultaneous implementation of prevention and treatment controls outperforms individual control methods in mitigating COVID-19 spread. Finally, sensitivity analysis conducted with constant controls shows the contributions of the controls to disease dynamics.
本研究提出了一个包含logistic招募率的COVID-19传播最优控制模型。观察结果表明,当种群存在阈值超过1时,存在无病平衡。平衡的稳定性由基本繁殖数R0决定。这意味着当R0小于等于1时平衡是稳定的,当R0大于1时平衡是不稳定的。此外,当R0超过1时,记录了地方性平衡和稳定性。为了确定COVID-19传播的影响因素,进行了敏感性指数和R0的敏感性分析。该模型完美地结合了预防和治疗控制。因此,数值模拟结果表明,预防控制比治疗控制在减少COVID-19传播方面更有效。此外,预防和治疗控制同时实施,在缓解COVID-19传播方面优于单独控制方法。最后,在恒定控制下进行的敏感性分析显示了控制对疾病动力学的贡献。
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引用次数: 0
Deterministic compartmental model for optimal control strategies of Giardiasis infection with saturating incidence and environmental dynamics 具有饱和发病率和环境动态的贾第虫病感染最优控制策略的确定性室室模型
Pub Date : 2025-01-07 DOI: 10.1016/j.health.2025.100383
Stephen Edward , Nyimvua Shaban
This study develops a deterministic compartmental model that tracks Giardiasis’s direct and indirect transmission dynamics. The study begins by constructing a model incorporating four constant controls: health education, screening, hospitalization, and sanitation. The analytical results of the model are investigated and presented. The positivity of the solutions and the existence of invariant regions were established. The model exhibits a unique disease-free equilibrium and multiple endemic equilibria. The effective reproduction number was derived using the Next-Generation Matrix (NGM) approach, and its implications for the stability of the equilibria were explored. Local stability of the disease-free equilibrium was confirmed using the Routh–Hurwitz criteria, while global stability results were also presented. Sensitivity analysis was conducted based on the effective reproduction number, identifying the most influential parameters. We introduce an optimal control problem to curb the spread of Giardiasis. We rigorously establish the existence of optimal control solutions and analytically characterize these solutions using Pontryagin’s Maximum Principle. We conduct numerical simulations to evaluate the effectiveness of various control strategies. The results are promising, showing that the simultaneous implementation of all four control measures, education, screening, treatment, and sanitation, can lead to a significant reduction in disease cases, thereby offering a reassuring solution to the spread of Giardiasis.
本研究开发了一个确定性的室室模型,跟踪贾第虫病的直接和间接传播动力学。该研究首先构建了一个包含四个恒定控制因素的模型:健康教育、筛查、住院和卫生。对模型的分析结果进行了研究和介绍。证明了解的正性和不变量区域的存在性。该模型具有独特的无病平衡和多个地方性平衡。利用新一代矩阵(NGM)方法推导了有效繁殖数,并探讨了其对平衡稳定性的影响。利用Routh-Hurwitz准则证实了无病平衡的局部稳定性,同时也给出了全局稳定性结果。根据有效繁殖数进行敏感性分析,找出影响最大的参数。我们引入一个最优控制问题来抑制贾第虫病的传播。我们严格地建立了最优控制解的存在性,并利用庞特里亚金极大值原理对这些解进行了解析表征。我们通过数值模拟来评估各种控制策略的有效性。结果令人鼓舞,表明同时实施所有四项控制措施,即教育、筛查、治疗和卫生,可导致疾病病例显著减少,从而为贾第虫病的传播提供了一种令人放心的解决方案。
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引用次数: 0
An exploration of machine learning approaches for early Autism Spectrum Disorder detection 机器学习方法在早期自闭症谱系障碍检测中的探索
Pub Date : 2025-01-06 DOI: 10.1016/j.health.2024.100379
Nawshin Haque, Tania Islam, Md Erfan
Autism Spectrum Disorder is a neurodevelopmental condition impacting an individual’s repetitive behaviours, social skills, verbal and nonverbal communication abilities, and capacity for acquiring new knowledge. Manifesting typically in early childhood, specifically between 6 months and 5 years, the symptoms of autism exhibit a progressive nature over time. This study explores the application of Logistic Regression, Support Vector Classifier, K-Nearest Neighbour, Decision Tree, and Random Forest for predicting Autism in children and toddlers by leveraging advancements in machine learning. The efficacy of these techniques is evaluated using publicly accessible datasets specific to both age groups. The findings indicate remarkable performance, with the toddler dataset achieving a mean Intersection over Union (mIoU) of 100% for Support Vector Classifier and 99.80% for Logistic Regression. Similarly, the children dataset demonstrates outstanding results, achieving an mIoU of 100% for Support Vector Classifier and 99.96% for Logistic Regression. Furthermore, all algorithms achieved 100% accuracy on the children (age 4–11) dataset collected from real-world sources. Logistic Regression, Random Forest, Support Vector Classifier, and Decision Tree attained 100% accuracy and mIoU with the real-world dataset. These results underscore the potential of machine learning in aiding the early detection of ASD in children and toddlers, offering promising avenues for future research and clinical applications.
自闭症谱系障碍是一种影响个体重复行为、社交技能、语言和非语言沟通能力以及获取新知识能力的神经发育疾病。自闭症的症状通常表现在儿童早期,特别是在6个月到5岁之间,随着时间的推移,自闭症的症状表现出渐进的性质。本研究探讨了逻辑回归、支持向量分类器、k近邻、决策树和随机森林在预测儿童和幼儿自闭症方面的应用,利用机器学习的进步。使用针对两个年龄组的可公开访问的数据集来评估这些技术的有效性。研究结果显示了显著的性能,幼儿数据集实现了100%的支持向量分类器和99.80%的逻辑回归的平均交集(mIoU)。同样,儿童数据集也显示出出色的结果,支持向量分类器的mIoU为100%,逻辑回归的mIoU为99.96%。此外,所有算法在从现实世界中收集的儿童(4-11岁)数据集上都达到了100%的准确率。逻辑回归、随机森林、支持向量分类器和决策树在真实数据集上达到100%的准确率和mIoU。这些结果强调了机器学习在帮助儿童和幼儿早期发现ASD方面的潜力,为未来的研究和临床应用提供了有希望的途径。
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引用次数: 0
A large-scale risk assessment and classification model for pneumococcus using Finnish national health data 基于芬兰国家卫生数据的肺炎球菌大规模风险评估和分类模型
Pub Date : 2025-01-03 DOI: 10.1016/j.health.2025.100382
Viljami Männikkö , Juha Turunen , Heidi Åhman , Esa Harju
Streptococcus pneumoniae, or pneumococcus, poses a significant health risk, particularly to infants, the elderly, and individuals with underlying medical conditions. In Finland, pneumococcal vaccination is part of the national immunization program, with vaccination provided to young children and only selected at-risk adult populations included. This study aims to leverage the Finnish national electronic health record system, Kanta, to analyze treatment histories and identify individuals at increased risk for disease to improve vaccination strategies. Kanta provides a comprehensive, nationwide database of patient treatment histories, which can be utilized to track individual risk factors and disease episodes. We analyzed health data from 96,200 Finnish residents with risk factors for pneumococcal disease following guidelines from the Finnish Institute for Health and Welfare and the World Health Organization. We prioritize vaccination for those at the greatest risk by categorizing individuals based on their identified risk factors. This study demonstrates the potential for using national health record data to conduct large-scale risk analyses, allowing for more targeted and efficient vaccination strategies. The novelty of our approach lies in the automatic identification of high-risk individuals, which can inform public health initiatives and enhance the monitoring of pneumococcal disease risk at a population level.
肺炎链球菌或肺炎球菌具有重大的健康风险,特别是对婴儿、老年人和有潜在疾病的个体。在芬兰,肺炎球菌疫苗接种是国家免疫规划的一部分,仅向幼儿和选定的高危成年人口提供疫苗接种。本研究旨在利用芬兰国家电子健康记录系统Kanta来分析治疗史,并识别疾病风险增加的个体,以改进疫苗接种策略。Kanta提供了一个全面的、全国性的患者治疗史数据库,可用于跟踪个人风险因素和疾病发作。我们根据芬兰卫生与福利研究所和世界卫生组织的指导方针,分析了96,200名具有肺炎球菌疾病危险因素的芬兰居民的健康数据。我们根据已确定的危险因素对个体进行分类,优先为风险最大的人群接种疫苗。这项研究证明了利用国家健康记录数据进行大规模风险分析的潜力,从而允许制定更有针对性和更有效的疫苗接种战略。我们的方法的新颖之处在于自动识别高危人群,这可以为公共卫生措施提供信息,并在人群层面加强对肺炎球菌疾病风险的监测。
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引用次数: 0
A comparative assessment of machine learning models and algorithms for osteosarcoma cancer detection and classification 骨肉瘤癌症检测和分类的机器学习模型和算法的比较评估
Pub Date : 2025-01-02 DOI: 10.1016/j.health.2024.100380
Amoakoh Gyasi-Agyei
Osteosarcoma is a bone-forming tumor that is more common in children and young adults than in adults. Timely detection and classification of its type is crucial to its proper treatment and possible survival. Machine learning (ML) models trained on disease datasets are more effective in detection and classification than the conventional methods with hand-crafted features highly dependent on pathologists’ expertise. A publicly available raw osteosarcoma dataset was explored and then preprocessed using different combinations of data denoising techniques (including principal component analysis, mutual information gain, analysis of variance and Kendall’s rank correlation analysis) and data augmentation to derive seven different datasets. Using the seven derived datasets and eight ML algorithms, this study designed and performed an extensive comparative analysis of seven sets of ML models (altogether over 160 models) with their hyperparameters optimized using grid search. The performance differences between the learned ML models were then validated using repeated stratified 10-fold cross-validation and 5x2 cross-validation paired t-tests to select the best model for our task. The empirical model based on the extra trees algorithm and fitted to class-balanced dataset via random oversampling and multicollinearity removed via principal component analysis proved to be the best, as it detected and classified osteosarcoma cancer in 10 ms with 97.8% area under the receiver operating characteristics curve and acceptably low false alarm and misdetection. Thus, the proposed models can be cutting-edge techniques for automated detection and classification of osteosarcoma tumors to aid timely diagnosis, prognosis, and treatment.
骨肉瘤是一种骨形成肿瘤,在儿童和年轻人中比在成人中更常见。及时发现和分类其类型对其适当治疗和可能的生存至关重要。在疾病数据集上训练的机器学习(ML)模型在检测和分类方面比具有高度依赖病理学家专业知识的手工特征的传统方法更有效。研究人员探索了一个公开可用的原始骨肉瘤数据集,然后使用不同的数据去噪技术组合(包括主成分分析、互信息增益、方差分析和肯德尔秩相关分析)和数据增强进行预处理,得出七个不同的数据集。利用七个衍生数据集和八种机器学习算法,本研究设计并对七组机器学习模型(总共超过160个模型)进行了广泛的比较分析,并使用网格搜索优化了它们的超参数。然后使用重复分层10倍交叉验证和5倍交叉验证配对t检验验证学习ML模型之间的性能差异,以选择最适合我们任务的模型。基于额外树算法并通过随机过采样和主成分分析去除多重共线性拟合到类平衡数据集的经验模型被证明是最好的,因为它在10 ms内检测和分类骨肉瘤癌症,接受者工作特征曲线下面积为97.8%,可接受的低虚警和误检。因此,所提出的模型可以成为骨肉瘤肿瘤自动检测和分类的前沿技术,有助于及时诊断、预后和治疗。
{"title":"A comparative assessment of machine learning models and algorithms for osteosarcoma cancer detection and classification","authors":"Amoakoh Gyasi-Agyei","doi":"10.1016/j.health.2024.100380","DOIUrl":"10.1016/j.health.2024.100380","url":null,"abstract":"<div><div>Osteosarcoma is a bone-forming tumor that is more common in children and young adults than in adults. Timely detection and classification of its type is crucial to its proper treatment and possible survival. Machine learning (ML) models trained on disease datasets are more effective in detection and classification than the conventional methods with hand-crafted features highly dependent on pathologists’ expertise. A publicly available raw osteosarcoma dataset was explored and then preprocessed using different combinations of data denoising techniques (including principal component analysis, mutual information gain, analysis of variance and Kendall’s rank correlation analysis) and data augmentation to <em>derive</em> seven different datasets. Using the seven derived datasets and eight ML algorithms, this study designed and performed an extensive comparative analysis of seven sets of ML models (altogether over 160 models) with their hyperparameters optimized using grid search. The performance differences between the learned ML models were then validated using repeated stratified 10-fold cross-validation and 5x2 cross-validation paired <em>t</em>-tests to select the best model for our task. The empirical model based on the extra trees algorithm and fitted to class-balanced dataset via random oversampling and multicollinearity removed via principal component analysis proved to be the best, as it detected and classified osteosarcoma cancer in 10 ms with 97.8% area under the receiver operating characteristics curve and acceptably low false alarm and misdetection. Thus, the proposed models can be cutting-edge techniques for automated detection and classification of osteosarcoma tumors to aid timely diagnosis, prognosis, and treatment.</div></div>","PeriodicalId":73222,"journal":{"name":"Healthcare analytics (New York, N.Y.)","volume":"7 ","pages":"Article 100380"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An efficient blood supply chain network model with multiple echelons for managing outdated products 一种高效的多梯队血液供应链网络模型,用于过期产品的管理
Pub Date : 2024-12-18 DOI: 10.1016/j.health.2024.100377
Agus Mansur , Ivan Darma Wangsa , Novrianty Rizky , Iwan Vanany
This study examines the lack of coordination between blood production and inventories in the blood supply chain networks. Prior studies neglect to optimize operational costs through blood production, inventory, and waste. We propose a mixed-integer linear programming approach addressing multiple echelons, types of blood, and blood bag shelf lifetime. The model is developed by determining the facility locations, assigning regional blood banks, and allocating the right products. Indonesia's blood supply chain is used as a case study to evaluate the applicability of the proposed model using optimization software. A sensitivity analysis is performed on production rate and patient demand to assess how these factors affect the overall cost of expired products. The results show that the proposed method's total cost and expired products are 4.69%–5.60% and 4.71%–5.75%, respectively.
本研究探讨了血液供应链网络中血液生产和库存之间缺乏协调。先前的研究忽略了通过血液生产、库存和浪费来优化运营成本。我们提出了一种混合整数线性规划方法来处理多梯队、血液类型和血袋保质期。该模型是通过确定设施位置、分配区域血库和分配正确的产品来开发的。以印度尼西亚的血液供应链为例,利用优化软件评估所提出模型的适用性。对生产率和患者需求进行敏感性分析,以评估这些因素如何影响过期产品的总成本。结果表明,该方法的总成本为4.69% ~ 5.60%,过期产品为4.71% ~ 5.75%。
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引用次数: 0
An enhanced machine learning approach with stacking ensemble learner for accurate liver cancer diagnosis using feature selection and gene expression data 基于特征选择和基因表达数据的肝癌准确诊断的增强机器学习方法
Pub Date : 2024-12-12 DOI: 10.1016/j.health.2024.100373
Amena Mahmoud , Eiko Takaoka
Liver cancer is a significant global health concern, necessitating accurate and timely diagnosis for effective treatment. Machine learning approaches have emerged as promising tools for improving liver cancer classification using gene expression data in recent years. This study presents an advanced machine learning approach for liver cancer diagnosis using gene expression data, combining feature selection techniques with a stacking ensemble learning model. Our method addresses the challenges of high dimensionality and complex patterns in genomic data to improve diagnostic accuracy and interpretability. We employed a feature selection process to identify the most relevant gene expressions associated with liver cancer. This approach reduced the dimensionality of the data while preserving crucial biological information. The selected features were then used to train a stacking ensemble model, which combined multiple base learners, including Multi-Layer Perceptron (MLP), Random Forest (RF) model, K-nearest neighbor (KNN) model, and Support vector machine (SVM), with a meta-learner Extreme Gradient Boosting (Xgboost) model to make final predictions. The stacking ensemble achieved an accuracy of (97%), outperforming individual machine learning algorithms and traditional diagnostic methods. Furthermore, the model demonstrated high sensitivity (96.8%) and specificity (98.1%), crucial for early detection and minimizing false positives.
肝癌是一个重大的全球健康问题,需要准确和及时的诊断才能有效治疗。近年来,机器学习方法已成为利用基因表达数据改进肝癌分类的有前途的工具。本研究提出了一种利用基因表达数据进行肝癌诊断的先进机器学习方法,将特征选择技术与堆叠集成学习模型相结合。我们的方法解决了基因组数据中高维和复杂模式的挑战,以提高诊断的准确性和可解释性。我们采用特征选择过程来确定与肝癌相关的最相关的基因表达。这种方法降低了数据的维数,同时保留了关键的生物信息。然后使用选择的特征来训练堆叠集成模型,该模型结合了多个基础学习器,包括多层感知器(MLP),随机森林(RF)模型,k -近邻(KNN)模型和支持向量机(SVM),以及元学习器极端梯度增强(Xgboost)模型来进行最终预测。堆叠集成实现了(97%)的准确率,优于单个机器学习算法和传统诊断方法。此外,该模型具有很高的灵敏度(96.8%)和特异性(98.1%),这对于早期检测和减少假阳性至关重要。
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引用次数: 0
An integrated stacked convolutional neural network and the levy flight-based grasshopper optimization algorithm for predicting heart disease 一种集成的堆叠卷积神经网络和基于levy飞行的蚱蜢优化算法用于心脏病预测
Pub Date : 2024-12-07 DOI: 10.1016/j.health.2024.100374
Syed Muhammad Salman Bukhari , Muhammad Hamza Zafar , Syed Kumayl Raza Moosavi , Majad Mansoor , Filippo Sanfilippo
Cardiovascular disease is the leading cause of death worldwide, including critical conditions such as blood vessel blockage, heart failure, and stroke. Accurate and early prediction of heart disease remains a significant challenge due to the complexity of symptoms and the variability of contributing factors. This study proposes a novel hybrid model integrating a Stacked Convolutional Neural Network (SCNN) with the Levy Flight-based Grasshopper Optimization Algorithm (LFGOA) to address this challenge. The SCNN provides robust feature extraction, while LFGOA enhances the model by optimizing hyperparameters, improving classification accuracy, and reducing overfitting. The proposed approach is evaluated using four publicly available heart disease datasets, each representing diverse clinical and demographic features. Compared to traditional classifiers, including Regression Trees, Support Vector Machine, Logistic Regression, K-Nearest Neighbors, and standard Neural Networks, the SCNN-LFGOA consistently outperforms these methods. The results highlight that the SCNN-LFGOA achieves an average accuracy of 99%, with significant improvements in specificity, sensitivity, and F1-Score, showcasing its adaptability and robustness across datasets. This study highlights the SCNN-LFGOA's potential as a transformative tool for early and accurate heart disease prediction, contributing to improved patient outcomes and more efficient healthcare resource utilization. By combining deep learning with an advanced optimization technique, this research introduces a scalable and effective solution to a critical healthcare problem.
心血管疾病是世界范围内导致死亡的主要原因,包括血管阻塞、心力衰竭和中风等严重疾病。由于症状的复杂性和促成因素的可变性,对心脏病的准确和早期预测仍然是一项重大挑战。本研究提出了一种新的混合模型,将堆叠卷积神经网络(SCNN)与Levy基于飞行的蚱蜢优化算法(LFGOA)相结合,以解决这一挑战。SCNN提供鲁棒性特征提取,而LFGOA通过优化超参数、提高分类精度和减少过拟合来增强模型。所提出的方法使用四个公开可用的心脏病数据集进行评估,每个数据集代表不同的临床和人口统计学特征。与传统分类器(包括回归树、支持向量机、逻辑回归、k近邻和标准神经网络)相比,SCNN-LFGOA始终优于这些方法。结果表明,SCNN-LFGOA的平均准确率达到99%,特异性、敏感性和F1-Score均有显著提高,显示出其在数据集上的适应性和鲁棒性。这项研究强调了SCNN-LFGOA作为早期和准确的心脏病预测的变革性工具的潜力,有助于改善患者的预后和更有效的医疗资源利用。通过将深度学习与先进的优化技术相结合,本研究为关键的医疗保健问题引入了可扩展且有效的解决方案。
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引用次数: 0
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Healthcare analytics (New York, N.Y.)
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