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An integrated data mining algorithms and meta-heuristic technique to predict the readmission risk of diabetic patients 预测糖尿病患者再入院风险的综合数据挖掘算法和元启发式技术
Pub Date : 2023-12-16 DOI: 10.1016/j.health.2023.100292
Masoomeh Zeinalnezhad , Saman Shishehchi

Reducing hospital readmission rate is a significant challenge in the healthcare industry for managers and policymakers seeking to improve healthcare and lower costs. This study integrates data mining and meta-heuristic techniques to predict the early readmission probability of diabetic patients within 30 days of discharge. The research dataset was obtained from the UC Irvine Machine Learning Repository, including 101765 instances with 50 features representing patient and hospital outcomes, collected from 130 US hospitals. After data preprocessing, including cleansing, sampling, and normalization, a Chi-square analysis is done to confirm and rank the 20 identified factors affecting the readmission risk. As the algorithms' performance could vary based on the features’ characteristics, several classification algorithms, including a Random Forest (RF), Neural Network (NN), and Support Vector Machine (SVM), are employed. Moreover, the Genetic Algorithm (GA) is integrated into the SVM algorithm, called GA-SVM, for hyper-parameter tuning and increasing the prediction accuracy. The performance of the models was evaluated using accuracy, recall, precision, and f-measure metrics. The results indicate that the accuracy of RF, GA-SVM, SVM, and NN are calculated respectively as 74.04 %, 73.52 %, 72.40 %, and 70.44 %. Using GA to adjust c and gamma hyper-parameters led to a 1.12 % increase in SVM prediction accuracy. In response to increasing demand and considering poor hospital conditions, particularly during epidemics, these findings point out the potential benefits of a more tailored methodology in managing diabetic patients.

降低再入院率是医疗行业管理者和政策制定者在改善医疗服务和降低成本方面面临的一项重大挑战。本研究整合了数据挖掘和元启发式技术,以预测糖尿病患者出院后 30 天内的早期再入院概率。研究数据集来自加州大学欧文分校的机器学习资料库,包括 101765 个实例和 50 个代表患者和医院结果的特征,收集自美国 130 家医院。经过数据预处理(包括清洗、采样和归一化)后,进行了卡方分析,以确认影响再入院风险的 20 个已识别因素并对其进行排序。由于算法的性能会因特征的不同而不同,因此采用了多种分类算法,包括随机森林(RF)、神经网络(NN)和支持向量机(SVM)。此外,遗传算法(GA)被集成到 SVM 算法中,称为 GA-SVM,用于超参数调整和提高预测精度。使用准确度、召回率、精确度和 f-measure 指标对模型的性能进行了评估。结果表明,RF、GA-SVM、SVM 和 NN 的准确率分别为 74.04%、73.52%、72.40% 和 70.44%。使用 GA 调整 c 和 gamma 超参数使 SVM 的预测准确率提高了 1.12%。为了应对日益增长的需求,并考虑到恶劣的医院条件,特别是在流行病期间,这些研究结果表明,在管理糖尿病患者时,采用更有针对性的方法可能会带来好处。
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引用次数: 0
A predictive analytics model using machine learning algorithms to estimate the risk of shock development among dengue patients 利用机器学习算法估算登革热病人休克风险的预测分析模型
Pub Date : 2023-12-12 DOI: 10.1016/j.health.2023.100290
Jun Kit Chaw , Sook Hui Chaw , Chai Hoong Quah , Shafrida Sahrani , Mei Choo Ang , Yanfeng Zhao , Tin Tin Ting

Dengue is a common viral disease in tropical and subtropical countries. The clinical manifestation of dengue has a wide spectrum, from asymptomatic seroconversion to severe dengue infection. Severe dengue is defined as dengue with the presence of specific symptoms, including severe plasma leakage leading to shock or the accumulation of fluids with respiratory distress, severe bleeding, and severe organ impairment. Examining the progression of shock with the integration of patients’ physiological information and biochemical parameters would help in understanding the progression of the disease and early detection of shock. In this study, physiological patient data diagnosed with dengue are collected from a University Malaya Medical Centre’s electronic record. A prediction model learned from the measurement of a patient’s physiological data is the basis for effective treatment and prevention of shock development in critically ill patients. Hence, this study presents the predictive performance of machine learning algorithms to estimate the risk of shock development among dengue patients. Logistic regression, decision trees, support vector machines and neural networks are evaluated. Lastly, ensemble learnings of bagging and boosting are also applied to the weak learner to optimize performance. The experimental results show that the bagging algorithm outperforms other competing methods with a 14.5% improvement from the individual decision tree. The full blood count (FBC) specifically haemoglobin (Hb) on day 2 is found to be a strong predictor for severe dengue occurrence.

登革热是热带和亚热带国家常见的病毒性疾病。登革热的临床表现范围很广,从无症状的血清转换到严重的登革热感染。重症登革热的定义是出现特定症状的登革热,包括严重的血浆渗漏导致休克或体液蓄积并伴有呼吸困难、严重出血和严重器官损伤。通过整合患者的生理信息和生化参数来研究休克的进展,有助于了解疾病的进展和早期发现休克。本研究从马来亚大学医疗中心的电子病历中收集了登革热患者的生理数据。通过测量病人的生理数据得出的预测模型是有效治疗和预防危重病人休克的基础。因此,本研究介绍了机器学习算法的预测性能,以估计登革热病人发生休克的风险。本研究对逻辑回归、决策树、支持向量机和神经网络进行了评估。最后,为了优化性能,还对弱学习者采用了袋式学习和提升学习的集合学习方法。实验结果表明,袋集算法优于其他竞争方法,比单个决策树提高了 14.5%。研究发现,第 2 天的全血细胞计数(FBC),特别是血红蛋白(Hb)是严重登革热发生的有力预测指标。
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引用次数: 0
A LinkedIn-based analysis of the U.S. dynamic adaptations in healthcare during the COVID-19 pandemic 基于 LinkedIn 对 COVID-19 大流行期间美国医疗保健动态适应性的分析
Pub Date : 2023-12-12 DOI: 10.1016/j.health.2023.100291
Theodoros Daglis, Konstantinos P. Tsagarakis

Despite its side effects on the global environment, the pandemic has created business opportunities for healthcare. This work utilizes LinkedIn data to examine the features of U.S. healthcare companies that operate within a COVID-19 framework. Data from 304 companies in May 2022 and 333 companies in June 2023 from COVID-19-related companies with LinkedIn presence in the U.S. has been collected and analyzed. This study investigates the distinct characteristics of these companies through statistical measures and analysis at the state level. Some of these companies were established long before the pandemic but shifted their orientation toward COVID-19 in response to the crisis, while many others emerged explicitly due to the pandemic. These companies are primarily active in “Health, wellness and fitness,” “Hospital and healthcare,” Nonprofit organization and management,” “Medical practice,” and “Civic and Social organizations.” We show most companies and employees are located in California, and most followers are in the companies in Washington in the first and California in the second data mining.

尽管大流行病对全球环境产生了副作用,但它也为医疗保健行业创造了商机。本研究利用 LinkedIn 数据研究了在 COVID-19 框架下运营的美国医疗保健公司的特点。我们收集并分析了 2022 年 5 月的 304 家公司和 2023 年 6 月的 333 家公司的数据,这些公司都与 COVID-19 相关,并在美国有 LinkedIn 存在。本研究通过州一级的统计措施和分析,调查了这些公司的显著特征。其中一些公司早在大流行之前就已成立,但在应对危机时将其定位转向了 COVID-19,而其他许多公司则是明确因大流行而出现的。这些公司主要活跃在 "健康、保健和健身"、"医院和医疗保健"、"非营利组织和管理"、"医疗实践 "以及 "公民和社会组织 "等领域。我们显示,大多数公司和员工都位于加利福尼亚州,而在第一次数据挖掘和第二次数据挖掘中,大多数追随者都在华盛顿州和加利福尼亚州的公司中。
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引用次数: 0
A novel convolutional neural network for identification of retinal layers using sliced optical coherence tomography images 利用切片光学相干断层扫描图像识别视网膜层的新型卷积神经网络
Pub Date : 2023-12-07 DOI: 10.1016/j.health.2023.100289
Akshat Tulsani , Jeh Patel , Preetham Kumar , Veena Mayya , Pavithra K.C. , Geetha M. , Sulatha V. Bhandary , Sameena Pathan

Retinal imaging is crucial for observing the retina and accurately diagnosing pathological problems. Optical Coherence Tomography (OCT) has been a transformative breakthrough for developing high-resolution cross-sectional images. It is imperative to delineate the multiple layers of the retina for a proper diagnosis. A novel segmentation-based approach is introduced in this study to identify seven distinct layers of the retina using OCT images. The developed approach presents SliceOCTNet, a customized U-shaped Convolutional Neural Network (CNN) that introduces group normalization and intricate skip connections. Paired alongside a hybrid loss function, the SliceOCTNet outperformed most state-of-the-art approaches. The introduction of Group Normalization in SliceOCTNet stabilized the model and improved layer identification even when working with small datasets. The use of skip connections also contributed to an improvement in the spatial outlook of the model. Implementing a hybrid loss function addresses the class imbalance problem in the dataset. Duke University’s spectral-domain optical coherence tomography (SD-OCT) B-scan dataset of healthy and Diabetic Macular Edema (DME) afflicted patients was utilized to train and evaluate the SliceOCTNet. The model accurately recognizes the seven layers of the retina. It can achieve a high dice coefficient value of 0.941 and refine the segmentation process to a higher level of precision.

视网膜成像对于观察视网膜和准确诊断病理问题至关重要。光学相干断层扫描(OCT)在开发高分辨率横截面图像方面取得了突破性进展。为了进行正确诊断,必须对视网膜的多个层次进行划分。本研究引入了一种基于分割的新方法,利用 OCT 图像识别视网膜的七个不同层。所开发的方法采用了 SliceOCTNet,这是一种定制的 U 型卷积神经网络(CNN),引入了组归一化和复杂的跳过连接。在混合损失函数的配合下,SliceOCTNet 的表现优于大多数最先进的方法。在 SliceOCTNet 中引入组归一化后,即使在处理小型数据集时,也能稳定模型并改进层识别。跳转连接的使用也有助于改善模型的空间前景。采用混合损失函数解决了数据集中的类不平衡问题。杜克大学的光谱域光学相干断层扫描(SD-OCT)B-扫描健康和糖尿病黄斑水肿(DME)患者数据集被用来训练和评估 SliceOCTNet。该模型能准确识别视网膜的七个层次。它的骰子系数高达 0.941,并能将分割过程细化到更高的精度水平。
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引用次数: 0
Supervised and unsupervised learning models for pharmaceutical drug rating and classification using consumer generated reviews 使用消费者评论的药品评级和分类的监督和无监督学习模型
Pub Date : 2023-12-06 DOI: 10.1016/j.health.2023.100288
Corban Allenbrand

Optimization of medication therapy depends on maximizing benefits and minimizing side effects of medications. This research showed how a joint approach using text mining, natural language processing, and machine learning can provide information for personalized and optimized medication therapy. Reviews on the benefits and side effects of prescription and over-the-counter medications were used to determine how well an integrated supervised and unsupervised learning could learn medication satisfaction. Supervised learning with naïve-Bayes, non-linear support vector machine with radial basis function kernels, and random forests with CART decision trees was measured by a micro-aggregated Matthews correlation coefficient and a macro-averaged F1 measure. Random forests outperformed support vector machines by almost 250% and naive-Bayes by 600% on the two evaluation metrics. All models did better with three rating levels, instead of five. Topic modeling and stacked cluster analysis were coupled with parts-of-speech tagging and text mining operations to establish a robust data preprocessing procedure to eliminate noisy features from the data. Unsupervised topic modeling and clustering represented an exploratory validation of how easy supervised classification would be. Well-defined latent topics were discovered including topics on “sleep quality”, “the opportunity to get back to work”, and “weight gain”. Overlapping clusters revealed that incorporating more information on social, demographic, or medical history variables could improve classifier performance. This research provided evidence that medication satisfaction can be learned with carefully designed joint supervised, unsupervised, and natural language learning techniques.

药物治疗的优化取决于药物的最大益处和最小副作用。这项研究展示了使用文本挖掘、自然语言处理和机器学习的联合方法如何为个性化和优化药物治疗提供信息。通过对处方药和非处方药的益处和副作用的评价来确定综合监督学习和非监督学习在学习药物满意度方面的效果。通过微聚集的马修斯相关系数和宏观平均的F1测度,对naïve-Bayes监督学习、径向基函数核非线性支持向量机和CART决策树随机森林进行测度。在两个评估指标上,随机森林比支持向量机高出250%,比朴素贝叶斯高出600%。所有型号都有三个等级,而不是五个等级。主题建模和堆叠聚类分析与词性标注和文本挖掘操作相结合,建立了一个鲁棒的数据预处理程序,以消除数据中的噪声特征。无监督主题建模和聚类代表了对监督分类有多容易的探索性验证。明确定义的潜在话题包括“睡眠质量”、“重返工作岗位的机会”和“体重增加”。重叠的聚类表明,结合更多关于社会、人口统计或病史变量的信息可以提高分类器的性能。这项研究提供的证据表明,药物满意度可以通过精心设计的联合监督、无监督和自然语言学习技术来学习。
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引用次数: 0
A flexible analytic wavelet transform and ensemble bagged tree model for electroencephalogram-based meditative mind-wandering detection 基于脑电图的冥想思维游走检测的灵活分析小波变换和集合袋装树模型
Pub Date : 2023-12-04 DOI: 10.1016/j.health.2023.100286
Ajay Dadhich , Jaideep Patel , Rovin Tiwari , Richa Verma , Pratha Mishra , Jay Kumar Jain

Mind-wandering (MW) is when an individual’s concentration drifts away from the task or activity. Researchers found a greater variability in electroencephalogram (EEG) signals due to MW. Collecting more nuanced information from raw EEG data to examine the harmful effects of MW is time-consuming. This study proposes a multi-resolution assessment of EEG signals using the flexible analytic wavelet transform (FAWT). The FAWT algorithm decomposes raw EEG data into more representative sub-bands (SBs). Several statistical characteristics are derived from the obtained SBs, and the effects of MW during meditation on the EEG signals are investigated. A set of significant characteristics is chosen and fed into the machine learning modules using a 10-fold validation approach to detect MW subjects automatically. Our proposed framework attained the highest classification accuracy of 92.41%, the highest sensitivity of 93.56%, and the highest specificity of 91.97%. The proposed framework can be used to design a suitable brain-computer interface (BCI) system to reduce MW and increase meditation depth for holistic and long-term health in society.

思维游离(MW)是指一个人的注意力偏离任务或活动。研究人员发现,MW 会导致脑电图(EEG)信号的更大变化。从原始脑电图数据中收集更多细微信息来研究 MW 的有害影响非常耗时。本研究提出使用灵活分析小波变换(FAWT)对脑电信号进行多分辨率评估。FAWT 算法将原始脑电图数据分解为更具代表性的子带 (SB)。从获得的子带中得出若干统计特征,并研究了冥想时 MW 对脑电信号的影响。我们选择了一组重要的特征,并将其输入机器学习模块,使用 10 倍验证方法自动检测 MW 受试者。我们提出的框架达到了 92.41% 的最高分类准确率、93.56% 的最高灵敏度和 91.97% 的最高特异性。所提出的框架可用于设计合适的脑机接口(BCI)系统,以减少MW和增加冥想深度,从而促进社会的整体和长期健康。
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引用次数: 0
An investigation of income inequality through autoregressive integrated moving average and regression analysis 通过自回归综合移动平均数和回归分析调查收入不平等问题
Pub Date : 2023-12-02 DOI: 10.1016/j.health.2023.100287
John Wang , Zhi Kacie Pei , Yawei Wang , Zhaoqiong Qin

Income inequality is a prominent contributor to health disparities in the U.S. As a leading capitalist nation, the U.S. registers the highest healthcare expenditure among developed countries yet grapples with widening income disparities. The chasm between the rich and the underprivileged has expanded significantly in recent decades, profoundly impacting American society. This study explores the nuances of income inequality, its ramifications, and potential remedies, analyzed through the Gini Coefficient. Advanced forecasting models, including AutoRegressive Integrated Moving Average and Regression Analysis, are employed to anticipate future patterns. The research highlights the value of healthcare analytics in understanding the complexities of income inequality. The findings underscore the pressing need for effective policies to address this mounting challenge.

作为一个主要的资本主义国家,美国是发达国家中医疗支出最高的国家,但却面临着收入差距不断扩大的问题。近几十年来,富人与弱势群体之间的鸿沟显著扩大,对美国社会产生了深远影响。本研究通过对基尼系数的分析,探讨了收入不平等的细微差别、其影响以及潜在的补救措施。研究采用了先进的预测模型,包括自回归综合移动平均法和回归分析法,以预测未来的模式。研究强调了医疗保健分析在了解收入不平等的复杂性方面的价值。研究结果强调,迫切需要制定有效的政策来应对这一日益严峻的挑战。
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引用次数: 0
An explainable artificial intelligence model for identifying local indicators and detecting lung disease from chest X-ray images 一个可解释的人工智能模型,用于从胸部x射线图像中识别局部指标和检测肺部疾病
Pub Date : 2023-12-01 DOI: 10.1016/j.health.2023.100206
Shiva prasad Koyyada , Thipendra P. Singh
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引用次数: 2
A Medical Cyber-physical system for predicting maternal health in developing countries using machine learning 利用机器学习预测发展中国家孕产妇健康状况的网络物理医疗系统
Pub Date : 2023-11-28 DOI: 10.1016/j.health.2023.100285
Mohammad Mobarak Hossain , Mohammod Abdul Kashem , Nasim Mahmud Nayan , Mohammad Asaduzzaman Chowdhury

It is essential to monitor any health issues during pregnancy to ensure a safe delivery because pregnancy is crucial for both mother and child. However, developing countries have poor access to healthcare, making managing possible health risks during pregnancy challenging. An Internet of Things (IoT)-based Medical Cyber-Physical System (MCPS) can offer a valuable and affordable solution for anticipating and controlling health hazards during pregnancy to solve this issue. This paper presents the design and development of an MCPS for recognizing health risks in pregnant women in developing countries. The system collects key health metrics using temperature, blood pressure, glucose levels, and heart rate sensors. It automatically considers risk factors to predict health risks using Machine Learning (ML) and sends them to the nearest clinic or hospital. Patients can manually enter their risk factors into the program and talk with a doctor through it. The efficacy of the proposed MCPS is evaluated using a dataset of pregnant women, and the results demonstrate that the system can accurately detect health issues during pregnancy. Medical experts can.

enhance maternal and fetal health outcomes using the systems real-time data collecting and processing capabilities. Despite restricted access to healthcare in developing countries, the proposed MCPS provides a valuable and economical method of addressing pregnancy-related health risks. The MCPS can assist medical personnel in making quick and informed choices, enhancing the level of care provided to expectant mothers and their unborn children.

由于怀孕对母婴都至关重要,因此必须监测孕期的任何健康问题,以确保安全分娩。然而,发展中国家的医疗条件很差,因此管理孕期可能出现的健康风险具有挑战性。为解决这一问题,基于物联网(IoT)的医疗网络物理系统(MCPS)可为预测和控制孕期健康危害提供有价值且经济实惠的解决方案。本文介绍了用于识别发展中国家孕妇健康风险的 MCPS 的设计和开发。该系统利用体温、血压、血糖水平和心率传感器收集关键的健康指标。它自动考虑风险因素,利用机器学习(ML)预测健康风险,并将其发送到最近的诊所或医院。患者可以手动将自己的风险因素输入程序,并通过程序与医生交流。我们使用一个孕妇数据集对所提议的 MCPS 的功效进行了评估,结果表明该系统能准确检测出孕期的健康问题。医学专家可以利用该系统的实时数据收集和处理能力,提高孕产妇和胎儿的健康水平。尽管发展中国家的医疗条件有限,但拟议的 MCPS 为解决与妊娠有关的健康风险提供了一种有价值且经济的方法。MCPS 可以帮助医务人员迅速做出明智的选择,从而提高为准妈妈及其胎儿提供的护理水平。
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引用次数: 0
An analytical investigation of body parts more susceptible to aging and composition changes using statistical hypothesis testing 使用统计假设检验对易受老化和成分变化影响的身体部位进行分析研究
Pub Date : 2023-11-28 DOI: 10.1016/j.health.2023.100284
Masaya Mori , Roberto Gonzalez Flores , Hiroteru Kamimura , Kentaro Yamaura , Hirofumi Nonaka

In recent years, age-related changes in body composition in the elderly are attracting attention. This is associated with a decline in physical functions and an increased risk of disease development. In general, age-related changes in body composition can be minimized with appropriate exercise. However, there are no studies that investigate body parts susceptibility to aging and changes in body composition of those parts. Therefore, devising exercise programs and advising daily life while taking these into account becomes difficult. This study aims to identify body parts that are more susceptible to aging and their body composition changes. The body composition was obtained with a Direct Segmental Multi-frequency Bioelectrical Impedance Analysis using InBody770 in 8 male elderly patients who had been shortly hospitalized. Statistical hypothesis testing was used to determine whether site-specific body composition changed significantly between hospital discharge and 1 year, 1 year and 2 years, and hospital discharge and 2 years. The results showed that Lean body mass, Total Body Water, Intracellular Water, Extracellular Water in the right arm; Lean body mass and Total Body Water in the left arm and trunk are more sensitive to aging.

近年来,老年人身体成分与年龄相关的变化引起了人们的关注。这与身体功能下降和疾病发展风险增加有关。一般来说,通过适当的锻炼,可以将与年龄相关的身体成分变化降到最低。然而,没有研究调查身体部位对衰老的易感性以及这些部位的身体成分的变化。因此,在考虑这些因素的同时制定锻炼计划和建议日常生活变得很困难。这项研究的目的是找出更容易衰老的身体部位及其身体成分的变化。采用InBody770进行直接节段多频生物电阻抗分析,获得8例短期住院的老年男性患者的体成分。采用统计假设检验确定部位特异性体成分在出院至1年、1年至2年、出院至2年之间是否有显著变化。结果表明:右臂瘦体质量、总体水、细胞内水、细胞外水;左臂和躯干的瘦体重和总身体水分对衰老更敏感。
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引用次数: 0
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Healthcare analytics (New York, N.Y.)
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