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An enhanced multi-scale deep convolutional orchard capsule neural network for multi-modal breast cancer detection 用于多模态乳腺癌检测的增强型多尺度深度卷积果园胶囊神经网络
Pub Date : 2023-12-30 DOI: 10.1016/j.health.2023.100298
Sangeeta Parshionikar , Debnath Bhattacharyya

Breast cancer is the second-leading cause of cancer death in women. Breast cells develop into malignant, cancerous lumps, the first signs of breast cancer. Breast cancer can be discovered by the automated diagnostic system when it is still too little to be found by conventional medical methods. Early breast cancers identified with automated screening and diagnosis technologies are generally treatable. This study proposes an enhanced multi-scale deep Convolutional Capsule Neural Network (CapsNet) optimized with Orchard Optimization Algorithm for breast cancer detection. The proposed system consists of preprocessing, feature extraction, segmentation, and classification process. Two input images are taken initially: the Breast Cancer Histopathology Images dataset and the Infrared Thermal Images dataset. The quality of the collected data is improved, and unwanted noises are removed. The features are extracted to segment the image to derive a Region of Interest for effectively segmenting the affected region. Finally, the images are classified as benign/malignant for histopathology images and healthy/cancer for thermal images. The proposed CapsNet is implemented in Python, run for 200 epochs, and compared with existing methods in terms of evaluation metrics. The result shows that the proposed CapsNet attained 99.74 % accuracy, 0.0482 binary entropy loss on the Breast Cancer Histopathology Image dataset and 97 % accuracy, 0.2081 binary entropy loss on the Infrared Thermal Images dataset while incrementing the epochs at each level.

乳腺癌是女性癌症死亡的第二大原因。乳腺细胞发展成恶性肿瘤肿块是乳腺癌的最初征兆。当传统医学方法无法发现乳腺癌时,自动诊断系统就能发现乳腺癌。通过自动筛查和诊断技术发现的早期乳腺癌通常是可以治疗的。本研究提出了一种增强型多尺度深度卷积胶囊神经网络(CapsNet),利用奥查德优化算法进行优化,用于乳腺癌检测。该系统包括预处理、特征提取、分割和分类过程。首先采集两幅输入图像:乳腺癌组织病理学图像数据集和红外热图像数据集。对采集到的数据进行质量改进,并去除不需要的噪音。提取特征后,对图像进行分割,得出感兴趣区域,从而有效分割受影响区域。最后,对组织病理学图像进行良性/恶性分类,对热图像进行健康/癌症分类。所提出的 CapsNet 是用 Python 实现的,运行了 200 个历时,并与现有方法的评估指标进行了比较。结果表明,在乳腺癌组织病理学图像数据集上,所提出的 CapsNet 的准确率达到 99.74%,二元熵损失为 0.0482;在红外热图像数据集上,准确率达到 97%,二元熵损失为 0.2081。
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引用次数: 0
A novel machine learning algorithm for finger movement classification from surface electromyogram signals using welch power estimation 利用韦尔奇功率估算从表面肌电信号进行手指运动分类的新型机器学习算法
Pub Date : 2023-12-27 DOI: 10.1016/j.health.2023.100296
Afroza Sultana , Md Tawhid Islam Opu , Farruk Ahmed , Md Shafiul Alam

Electromyogram (EMG) signal monitoring is an effective method for controlling the movements of a prosthetic limb. The classification of the EMG pattern of various finger motions in upper-arm amputees has drawn much attention in recent years to develop algorithms that provide adequate accuracy. However, due to the complexity of EMG data, movement detection is a challenging task. Therefore, an effective model is needed that can accurately process, analyze, and classify various hand and finger movements. This paper proposes a novel algorithm for processing and classifying 15 finger movements from surface EMG signals based on Welch power estimation from frequency analysis. Five time-domain features are extracted and trained with a machine learning classifier to classify 15 single fingers and combined finger gestures from eight healthy subjects. The experimental results show 92.30 % classification accuracy considering data from eight channels which was improved to 94.15 % after selecting two channels as dominating. For performance evaluation, 10-fold cross-validation is used during classification. We demonstrate an average accuracy of 92.35 % with 25 % test data.

肌电图(EMG)信号监测是控制假肢运动的有效方法。近年来,对上臂截肢者各种手指运动的肌电图模式进行分类以开发具有足够准确性的算法引起了广泛关注。然而,由于 EMG 数据的复杂性,运动检测是一项具有挑战性的任务。因此,需要一个有效的模型来准确处理、分析和分类各种手部和手指运动。本文提出了一种基于频率分析韦尔奇功率估计的新算法,用于处理表面肌电信号中的 15 个手指动作并对其进行分类。本文提取了五个时域特征,并使用机器学习分类器对八个健康受试者的 15 个单指和组合手指手势进行了分类训练。实验结果表明,考虑到八个通道的数据,分类准确率为 92.30%,在选择两个通道作为主要通道后,分类准确率提高到 94.15%。在进行性能评估时,分类过程中使用了 10 倍交叉验证。在 25% 测试数据的情况下,平均准确率为 92.35%。
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引用次数: 0
A health information systems architecture study in intellectual disability care: Commonalities and variabilities 智障护理中的医疗信息系统架构研究:共性与差异
Pub Date : 2023-12-23 DOI: 10.1016/j.health.2023.100295
J. Tummers , H. Tobi , C. Catal , B. Tekinerdogan , B. Schalk , G. Leusink

Care providers in intellectual disability care use various health information systems (HIS) to document the care they provide. This generates a substantial amount of structured and unstructured data with significant potential for reuse, which is currently underexploited. To enhance data reuse, it is important to understand the architecture of health information systems in intellectual disability care, including their commonalities and variabilities (differences), as well as to identify related privacy and security issues. Our study adopts a multiple-case study approach, examining the architectures of four health information systems in the Netherlands. We conducted interviews with seven stakeholders from four HISs and reviewed multiple documents concerning system infrastructure. We identified commonalities and differences between these systems and outlined the primary challenges regarding privacy and security for data reuse. For each HIS, four architectural views were developed: a context diagram, decomposition view, layered view, and deployment view. The study discusses crucial security and privacy aspects for data reuse in intellectual disability care and highlights several challenges that must be addressed to unlock the full potential of this data. This research provides initial guidelines for overcoming these challenges.

智障护理服务提供者使用各种医疗信息系统(HIS)来记录他们所提供的护理服务。由此产生的大量结构化和非结构化数据具有巨大的重用潜力,但目前尚未得到充分利用。为了加强数据再利用,了解智障护理中医疗信息系统的架构非常重要,包括其共性和差异性(差异),以及确定相关的隐私和安全问题。我们的研究采用了多案例研究方法,考察了荷兰四个医疗信息系统的架构。我们对四个医疗信息系统的七位利益相关者进行了访谈,并查阅了有关系统基础设施的多份文件。我们确定了这些系统之间的共性和差异,并概述了数据再利用在隐私和安全方面面临的主要挑战。我们为每个 HIS 开发了四种架构视图:上下文图、分解视图、分层视图和部署视图。本研究讨论了智障护理中数据再利用的关键安全和隐私问题,并强调了释放这些数据的全部潜力所必须应对的几个挑战。本研究为克服这些挑战提供了初步指南。
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引用次数: 0
An intuitionistic fuzzy differential equation approach for the lake water and sediment phosphorus model 湖泊水和沉积物磷模型的直观模糊微分方程方法
Pub Date : 2023-12-19 DOI: 10.1016/j.health.2023.100294
Ashish Acharya , Sanjoy Mahato , Nikhilesh Sil , Animesh Mahata , Supriya Mukherjee , Sanat Kumar Mahato , Banamali Roy

Intuitionistic fuzzy sets cannot consider the degree of indeterminacy (i.e., the degree of hesitation). This study presents an intuitionistic fuzzy differential equation approach for the lake water and sediment phosphorus model. We examine the proposed model by assuming generalized trapezoidal intuitionistic fuzzy numbers for the initial condition. Feasible equilibrium points, along with their stability criteria, are evaluated. We describe the characteristics of intuitionistic fuzzy solutions and clarify the difference between strong and weak intuitionistic fuzzy solutions. Numerical simulations are performed in MATLAB to validate the model results.

直观模糊集无法考虑不确定程度(即犹豫程度)。本研究提出了一种湖泊水和沉积物磷模型的直观模糊微分方程方法。我们通过假设初始条件为广义梯形直觉模糊数来检验所提出的模型。评估了可行的平衡点及其稳定性标准。我们描述了直觉模糊解的特点,并阐明了强直觉模糊解和弱直觉模糊解之间的区别。我们使用 MATLAB 进行了数值模拟,以验证模型结果。
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引用次数: 0
An integrated data mining algorithms and meta-heuristic technique to predict the readmission risk of diabetic patients 预测糖尿病患者再入院风险的综合数据挖掘算法和元启发式技术
Pub Date : 2023-12-16 DOI: 10.1016/j.health.2023.100292
Masoomeh Zeinalnezhad , Saman Shishehchi

Reducing hospital readmission rate is a significant challenge in the healthcare industry for managers and policymakers seeking to improve healthcare and lower costs. This study integrates data mining and meta-heuristic techniques to predict the early readmission probability of diabetic patients within 30 days of discharge. The research dataset was obtained from the UC Irvine Machine Learning Repository, including 101765 instances with 50 features representing patient and hospital outcomes, collected from 130 US hospitals. After data preprocessing, including cleansing, sampling, and normalization, a Chi-square analysis is done to confirm and rank the 20 identified factors affecting the readmission risk. As the algorithms' performance could vary based on the features’ characteristics, several classification algorithms, including a Random Forest (RF), Neural Network (NN), and Support Vector Machine (SVM), are employed. Moreover, the Genetic Algorithm (GA) is integrated into the SVM algorithm, called GA-SVM, for hyper-parameter tuning and increasing the prediction accuracy. The performance of the models was evaluated using accuracy, recall, precision, and f-measure metrics. The results indicate that the accuracy of RF, GA-SVM, SVM, and NN are calculated respectively as 74.04 %, 73.52 %, 72.40 %, and 70.44 %. Using GA to adjust c and gamma hyper-parameters led to a 1.12 % increase in SVM prediction accuracy. In response to increasing demand and considering poor hospital conditions, particularly during epidemics, these findings point out the potential benefits of a more tailored methodology in managing diabetic patients.

降低再入院率是医疗行业管理者和政策制定者在改善医疗服务和降低成本方面面临的一项重大挑战。本研究整合了数据挖掘和元启发式技术,以预测糖尿病患者出院后 30 天内的早期再入院概率。研究数据集来自加州大学欧文分校的机器学习资料库,包括 101765 个实例和 50 个代表患者和医院结果的特征,收集自美国 130 家医院。经过数据预处理(包括清洗、采样和归一化)后,进行了卡方分析,以确认影响再入院风险的 20 个已识别因素并对其进行排序。由于算法的性能会因特征的不同而不同,因此采用了多种分类算法,包括随机森林(RF)、神经网络(NN)和支持向量机(SVM)。此外,遗传算法(GA)被集成到 SVM 算法中,称为 GA-SVM,用于超参数调整和提高预测精度。使用准确度、召回率、精确度和 f-measure 指标对模型的性能进行了评估。结果表明,RF、GA-SVM、SVM 和 NN 的准确率分别为 74.04%、73.52%、72.40% 和 70.44%。使用 GA 调整 c 和 gamma 超参数使 SVM 的预测准确率提高了 1.12%。为了应对日益增长的需求,并考虑到恶劣的医院条件,特别是在流行病期间,这些研究结果表明,在管理糖尿病患者时,采用更有针对性的方法可能会带来好处。
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引用次数: 0
A predictive analytics model using machine learning algorithms to estimate the risk of shock development among dengue patients 利用机器学习算法估算登革热病人休克风险的预测分析模型
Pub Date : 2023-12-12 DOI: 10.1016/j.health.2023.100290
Jun Kit Chaw , Sook Hui Chaw , Chai Hoong Quah , Shafrida Sahrani , Mei Choo Ang , Yanfeng Zhao , Tin Tin Ting

Dengue is a common viral disease in tropical and subtropical countries. The clinical manifestation of dengue has a wide spectrum, from asymptomatic seroconversion to severe dengue infection. Severe dengue is defined as dengue with the presence of specific symptoms, including severe plasma leakage leading to shock or the accumulation of fluids with respiratory distress, severe bleeding, and severe organ impairment. Examining the progression of shock with the integration of patients’ physiological information and biochemical parameters would help in understanding the progression of the disease and early detection of shock. In this study, physiological patient data diagnosed with dengue are collected from a University Malaya Medical Centre’s electronic record. A prediction model learned from the measurement of a patient’s physiological data is the basis for effective treatment and prevention of shock development in critically ill patients. Hence, this study presents the predictive performance of machine learning algorithms to estimate the risk of shock development among dengue patients. Logistic regression, decision trees, support vector machines and neural networks are evaluated. Lastly, ensemble learnings of bagging and boosting are also applied to the weak learner to optimize performance. The experimental results show that the bagging algorithm outperforms other competing methods with a 14.5% improvement from the individual decision tree. The full blood count (FBC) specifically haemoglobin (Hb) on day 2 is found to be a strong predictor for severe dengue occurrence.

登革热是热带和亚热带国家常见的病毒性疾病。登革热的临床表现范围很广,从无症状的血清转换到严重的登革热感染。重症登革热的定义是出现特定症状的登革热,包括严重的血浆渗漏导致休克或体液蓄积并伴有呼吸困难、严重出血和严重器官损伤。通过整合患者的生理信息和生化参数来研究休克的进展,有助于了解疾病的进展和早期发现休克。本研究从马来亚大学医疗中心的电子病历中收集了登革热患者的生理数据。通过测量病人的生理数据得出的预测模型是有效治疗和预防危重病人休克的基础。因此,本研究介绍了机器学习算法的预测性能,以估计登革热病人发生休克的风险。本研究对逻辑回归、决策树、支持向量机和神经网络进行了评估。最后,为了优化性能,还对弱学习者采用了袋式学习和提升学习的集合学习方法。实验结果表明,袋集算法优于其他竞争方法,比单个决策树提高了 14.5%。研究发现,第 2 天的全血细胞计数(FBC),特别是血红蛋白(Hb)是严重登革热发生的有力预测指标。
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引用次数: 0
A LinkedIn-based analysis of the U.S. dynamic adaptations in healthcare during the COVID-19 pandemic 基于 LinkedIn 对 COVID-19 大流行期间美国医疗保健动态适应性的分析
Pub Date : 2023-12-12 DOI: 10.1016/j.health.2023.100291
Theodoros Daglis, Konstantinos P. Tsagarakis

Despite its side effects on the global environment, the pandemic has created business opportunities for healthcare. This work utilizes LinkedIn data to examine the features of U.S. healthcare companies that operate within a COVID-19 framework. Data from 304 companies in May 2022 and 333 companies in June 2023 from COVID-19-related companies with LinkedIn presence in the U.S. has been collected and analyzed. This study investigates the distinct characteristics of these companies through statistical measures and analysis at the state level. Some of these companies were established long before the pandemic but shifted their orientation toward COVID-19 in response to the crisis, while many others emerged explicitly due to the pandemic. These companies are primarily active in “Health, wellness and fitness,” “Hospital and healthcare,” Nonprofit organization and management,” “Medical practice,” and “Civic and Social organizations.” We show most companies and employees are located in California, and most followers are in the companies in Washington in the first and California in the second data mining.

尽管大流行病对全球环境产生了副作用,但它也为医疗保健行业创造了商机。本研究利用 LinkedIn 数据研究了在 COVID-19 框架下运营的美国医疗保健公司的特点。我们收集并分析了 2022 年 5 月的 304 家公司和 2023 年 6 月的 333 家公司的数据,这些公司都与 COVID-19 相关,并在美国有 LinkedIn 存在。本研究通过州一级的统计措施和分析,调查了这些公司的显著特征。其中一些公司早在大流行之前就已成立,但在应对危机时将其定位转向了 COVID-19,而其他许多公司则是明确因大流行而出现的。这些公司主要活跃在 "健康、保健和健身"、"医院和医疗保健"、"非营利组织和管理"、"医疗实践 "以及 "公民和社会组织 "等领域。我们显示,大多数公司和员工都位于加利福尼亚州,而在第一次数据挖掘和第二次数据挖掘中,大多数追随者都在华盛顿州和加利福尼亚州的公司中。
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引用次数: 0
A novel convolutional neural network for identification of retinal layers using sliced optical coherence tomography images 利用切片光学相干断层扫描图像识别视网膜层的新型卷积神经网络
Pub Date : 2023-12-07 DOI: 10.1016/j.health.2023.100289
Akshat Tulsani , Jeh Patel , Preetham Kumar , Veena Mayya , Pavithra K.C. , Geetha M. , Sulatha V. Bhandary , Sameena Pathan

Retinal imaging is crucial for observing the retina and accurately diagnosing pathological problems. Optical Coherence Tomography (OCT) has been a transformative breakthrough for developing high-resolution cross-sectional images. It is imperative to delineate the multiple layers of the retina for a proper diagnosis. A novel segmentation-based approach is introduced in this study to identify seven distinct layers of the retina using OCT images. The developed approach presents SliceOCTNet, a customized U-shaped Convolutional Neural Network (CNN) that introduces group normalization and intricate skip connections. Paired alongside a hybrid loss function, the SliceOCTNet outperformed most state-of-the-art approaches. The introduction of Group Normalization in SliceOCTNet stabilized the model and improved layer identification even when working with small datasets. The use of skip connections also contributed to an improvement in the spatial outlook of the model. Implementing a hybrid loss function addresses the class imbalance problem in the dataset. Duke University’s spectral-domain optical coherence tomography (SD-OCT) B-scan dataset of healthy and Diabetic Macular Edema (DME) afflicted patients was utilized to train and evaluate the SliceOCTNet. The model accurately recognizes the seven layers of the retina. It can achieve a high dice coefficient value of 0.941 and refine the segmentation process to a higher level of precision.

视网膜成像对于观察视网膜和准确诊断病理问题至关重要。光学相干断层扫描(OCT)在开发高分辨率横截面图像方面取得了突破性进展。为了进行正确诊断,必须对视网膜的多个层次进行划分。本研究引入了一种基于分割的新方法,利用 OCT 图像识别视网膜的七个不同层。所开发的方法采用了 SliceOCTNet,这是一种定制的 U 型卷积神经网络(CNN),引入了组归一化和复杂的跳过连接。在混合损失函数的配合下,SliceOCTNet 的表现优于大多数最先进的方法。在 SliceOCTNet 中引入组归一化后,即使在处理小型数据集时,也能稳定模型并改进层识别。跳转连接的使用也有助于改善模型的空间前景。采用混合损失函数解决了数据集中的类不平衡问题。杜克大学的光谱域光学相干断层扫描(SD-OCT)B-扫描健康和糖尿病黄斑水肿(DME)患者数据集被用来训练和评估 SliceOCTNet。该模型能准确识别视网膜的七个层次。它的骰子系数高达 0.941,并能将分割过程细化到更高的精度水平。
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引用次数: 0
Supervised and unsupervised learning models for pharmaceutical drug rating and classification using consumer generated reviews 使用消费者评论的药品评级和分类的监督和无监督学习模型
Pub Date : 2023-12-06 DOI: 10.1016/j.health.2023.100288
Corban Allenbrand

Optimization of medication therapy depends on maximizing benefits and minimizing side effects of medications. This research showed how a joint approach using text mining, natural language processing, and machine learning can provide information for personalized and optimized medication therapy. Reviews on the benefits and side effects of prescription and over-the-counter medications were used to determine how well an integrated supervised and unsupervised learning could learn medication satisfaction. Supervised learning with naïve-Bayes, non-linear support vector machine with radial basis function kernels, and random forests with CART decision trees was measured by a micro-aggregated Matthews correlation coefficient and a macro-averaged F1 measure. Random forests outperformed support vector machines by almost 250% and naive-Bayes by 600% on the two evaluation metrics. All models did better with three rating levels, instead of five. Topic modeling and stacked cluster analysis were coupled with parts-of-speech tagging and text mining operations to establish a robust data preprocessing procedure to eliminate noisy features from the data. Unsupervised topic modeling and clustering represented an exploratory validation of how easy supervised classification would be. Well-defined latent topics were discovered including topics on “sleep quality”, “the opportunity to get back to work”, and “weight gain”. Overlapping clusters revealed that incorporating more information on social, demographic, or medical history variables could improve classifier performance. This research provided evidence that medication satisfaction can be learned with carefully designed joint supervised, unsupervised, and natural language learning techniques.

药物治疗的优化取决于药物的最大益处和最小副作用。这项研究展示了使用文本挖掘、自然语言处理和机器学习的联合方法如何为个性化和优化药物治疗提供信息。通过对处方药和非处方药的益处和副作用的评价来确定综合监督学习和非监督学习在学习药物满意度方面的效果。通过微聚集的马修斯相关系数和宏观平均的F1测度,对naïve-Bayes监督学习、径向基函数核非线性支持向量机和CART决策树随机森林进行测度。在两个评估指标上,随机森林比支持向量机高出250%,比朴素贝叶斯高出600%。所有型号都有三个等级,而不是五个等级。主题建模和堆叠聚类分析与词性标注和文本挖掘操作相结合,建立了一个鲁棒的数据预处理程序,以消除数据中的噪声特征。无监督主题建模和聚类代表了对监督分类有多容易的探索性验证。明确定义的潜在话题包括“睡眠质量”、“重返工作岗位的机会”和“体重增加”。重叠的聚类表明,结合更多关于社会、人口统计或病史变量的信息可以提高分类器的性能。这项研究提供的证据表明,药物满意度可以通过精心设计的联合监督、无监督和自然语言学习技术来学习。
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引用次数: 0
A flexible analytic wavelet transform and ensemble bagged tree model for electroencephalogram-based meditative mind-wandering detection 基于脑电图的冥想思维游走检测的灵活分析小波变换和集合袋装树模型
Pub Date : 2023-12-04 DOI: 10.1016/j.health.2023.100286
Ajay Dadhich , Jaideep Patel , Rovin Tiwari , Richa Verma , Pratha Mishra , Jay Kumar Jain

Mind-wandering (MW) is when an individual’s concentration drifts away from the task or activity. Researchers found a greater variability in electroencephalogram (EEG) signals due to MW. Collecting more nuanced information from raw EEG data to examine the harmful effects of MW is time-consuming. This study proposes a multi-resolution assessment of EEG signals using the flexible analytic wavelet transform (FAWT). The FAWT algorithm decomposes raw EEG data into more representative sub-bands (SBs). Several statistical characteristics are derived from the obtained SBs, and the effects of MW during meditation on the EEG signals are investigated. A set of significant characteristics is chosen and fed into the machine learning modules using a 10-fold validation approach to detect MW subjects automatically. Our proposed framework attained the highest classification accuracy of 92.41%, the highest sensitivity of 93.56%, and the highest specificity of 91.97%. The proposed framework can be used to design a suitable brain-computer interface (BCI) system to reduce MW and increase meditation depth for holistic and long-term health in society.

思维游离(MW)是指一个人的注意力偏离任务或活动。研究人员发现,MW 会导致脑电图(EEG)信号的更大变化。从原始脑电图数据中收集更多细微信息来研究 MW 的有害影响非常耗时。本研究提出使用灵活分析小波变换(FAWT)对脑电信号进行多分辨率评估。FAWT 算法将原始脑电图数据分解为更具代表性的子带 (SB)。从获得的子带中得出若干统计特征,并研究了冥想时 MW 对脑电信号的影响。我们选择了一组重要的特征,并将其输入机器学习模块,使用 10 倍验证方法自动检测 MW 受试者。我们提出的框架达到了 92.41% 的最高分类准确率、93.56% 的最高灵敏度和 91.97% 的最高特异性。所提出的框架可用于设计合适的脑机接口(BCI)系统,以减少MW和增加冥想深度,从而促进社会的整体和长期健康。
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Healthcare analytics (New York, N.Y.)
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