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The Impact of Valve Stenosis and Replacement on Wave Characteristics in Cardiac Shear Wave Elastography 瓣膜狭窄及瓣膜置换术对心脏横波弹性成像波形特性的影响
Pub Date : 2025-06-06 DOI: 10.1109/OJUFFC.2025.3577142
Laurine Wouters;Lennert Minten;Marta Orlowska;Annette Caenen;Jürgen Duchenne;Jens-Uwe Voigt;Jan D’Hooge
Cardiac shear wave elastography (SWE) is a non-invasive technique to assess myocardial stiffness, based on the speed of waves that travel through the heart after valve closure. The wave physics underlying natural SWE remains incompletely understood. Therefore, we investigated the impact of wave excitation sources on 3 wave propagation aspects – wave amplitude (determined as wave acceleration magnitude), temporal wave width and speed. SWE was applied to 17 patients with aortic stenosis (AS), 13 AS patients that underwent transcatheter aortic valve implantation (TAVI), 10 AS patients that underwent surgical aortic valve replacement (AVR) and 18 age-matched healthy volunteers (HV). Absolute wave acceleration was lower in AS, TAVI and AVR patients compared to HV (1.5±0.60 vs 2.8±1.1 m/s2; p=0.001; 1.6±0.78 vs 2.8±1.1 m/s2; p=0.010; 1.7±0.66 vs 2.8±1.1 m/s2; p=0.015). Wave acceleration amplitude (measured as negative peak acceleration of the tissue) correlated with wave speed (r=0.388; p=0.003), implying that absolute wave acceleration is smaller in a stiffer heart. Subgroup analysis showed that the correlation between wave peak acceleration and speed is less steep in AS patients vs. HV (slopes: 0.23 vs 0.47 s). This implies that stenotic valves generate a wave with a lower acceleration magnitude compared to native valves. Further, temporal wave width was lower in TAVI patients vs. HV (8.7±2.3 vs 12.5±3.0 ms; p=0.002) and there was no difference in wave speed after aortic valve closure (AVC) between the groups. To conclude, wave acceleration magnitude and width offer additional insights into SWE physics next to wave speed and should be verified in a larger cohort.
心脏剪切波弹性成像(SWE)是一种评估心肌硬度的无创技术,基于瓣膜关闭后穿过心脏的波的速度。自然SWE背后的波动物理仍未完全被理解。因此,我们研究了波激励源对波传播3个方面的影响——波幅(以波加速度大小确定)、时间波宽度和速度。SWE应用于17例主动脉瓣狭窄患者(AS), 13例经导管主动脉瓣植入术(TAVI)的AS患者,10例手术主动脉瓣置换术(AVR)的AS患者和18例年龄匹配的健康志愿者(HV)。AS、TAVI和AVR患者的绝对波加速度较HV患者低(1.5±0.60 vs 2.8±1.1 m/s2;p = 0.001;1.6±0.78 vs 2.8±1.1 m/s2;p = 0.010;1.7±0.66 vs 2.8±1.1 m/s2;p = 0.015)。波加速度幅值(以组织负峰值加速度测量)与波速相关(r=0.388;P =0.003),这意味着在较硬的心脏中,绝对波加速度较小。亚组分析显示,AS患者与HV患者相比,波峰加速度和速度之间的相关性不那么陡峭(斜率:0.23 vs 0.47 s)。这意味着狭窄瓣膜产生的波与原生瓣膜相比具有较低的加速度量级。此外,TAVI患者的颞波宽度低于HV患者(8.7±2.3 vs 12.5±3.0 ms);p=0.002),两组间主动脉瓣关闭(AVC)后的波速无差异。综上所述,波加速度的大小和宽度除了波速之外,还提供了对SWE物理的进一步了解,应该在更大的队列中进行验证。
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引用次数: 0
IEEE OPEN JOURNAL OF ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL Ieee超音波学、铁电学与频率控制开放期刊
Pub Date : 2025-06-05 DOI: 10.1109/OJUFFC.2025.3541756
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引用次数: 0
Construction of Orthogonal Transmit Sequences Using the Nearest Orthogonal Matrix 用最近正交矩阵构造正交发射序列
Pub Date : 2025-06-04 DOI: 10.1109/OJUFFC.2025.3576722
Håvard Kjellmo Arnestad;Andreas Austeng;Sven Peter Näsholm
A wide variety of transmit sequences can be employed in medical ultrasound, including plane waves, diverging waves, and focused beams. The choice of sequence often involves trade-offs between resolution, signal-to-noise ratio (SNR), frame rate, and harmonic imaging capabilities. However, the desirable mathematical property of orthogonality (i.e., absence of cross-talk) between transmits has generally received less attention. This property, often lacking, becomes particularly relevant for the recent REFoCUS (retrospective encoding for conventional ultrasound sequences) technique, which we in this work connect to the array signal processing technique called beamspace processing. Given an arbitrary transmit sequence, REFoCUS enables the recovery of signals from single-element transmissions (known as the multistatic dataset) thereby enhancing beamforming flexibility. In this context, the choice of transmit sequence influences the recovery process when using the intuitively appealing and computationally efficient adjoint-based method, which must be replaced by a regularized pseudoinverse for general applicability. In the current work, we derive the “closest” alternative to any chosen transmit sequence that makes the regularized and adjoint methods yield equal estimates of the multistatic dataset, and show via numerical experiments a reduction in beam and/or element cross-talk. The derivation is based on a matrix nearness problem of finding the nearest orthogonal (or unitary) matrix to the encoding matrix using singular value decomposition (SVD). The resulting transmit sequences offer a time-domain equivalent understanding of the regularized REFoCUS method, as well as a solution for optimizing the invertibility of ultrasound sequences.
多种传输序列可用于医学超声,包括平面波、发散波和聚焦光束。序列的选择通常涉及分辨率、信噪比(SNR)、帧率和谐波成像能力之间的权衡。然而,传输之间的正交性(即无串扰)的理想数学性质通常受到的关注较少。这种通常缺乏的特性与最近的REFoCUS(传统超声序列的回顾性编码)技术特别相关,我们在这项工作中将其与称为波束空间处理的阵列信号处理技术联系起来。给定任意传输序列,REFoCUS能够从单元素传输(称为多静态数据集)中恢复信号,从而增强波束形成的灵活性。在这种情况下,当使用直观吸引和计算效率高的基于伴随的方法时,传输序列的选择会影响恢复过程,必须用正则化伪逆来代替。在当前的工作中,我们推导出任何选择的传输序列的“最接近”替代方案,使正则化和伴随方法产生多静态数据集的相等估计,并通过数值实验显示波束和/或单元串扰的减少。该推导是基于一个矩阵接近问题,即利用奇异值分解(SVD)找到距离编码矩阵最近的正交(或酉)矩阵。由此产生的传输序列提供了正则化REFoCUS方法的时域等效理解,以及优化超声序列可逆性的解决方案。
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引用次数: 0
Online Scaphoid Tracking Using a Wearable and Flexible Ultrasound Array: A First Proof of Concept 使用可穿戴和柔性超声阵列的在线舟状骨跟踪:第一个概念验证
Pub Date : 2025-04-30 DOI: 10.1109/OJUFFC.2025.3566006
Hasti Rostamikhanghahi;Marcus Ingram;Brian G. Booth;Jan D’Hooge
Percutaneous Scaphoid Fixation is a minimally invasive technique used to treat fractures of the scaphoid, the most fractured bone in the wrist. A significant challenge in this procedure is managing complications due to scaphoid movement due to wrist motion. This study aims to enhance the effectiveness of the intervention by introducing a novel wearable ultrasound array capable of flexible adherence and real-time tracking. By accurately monitoring scaphoid movement throughout the surgery, this innovation seeks to improve the overall success of the treatment. In previous research, a wearable transducer was designed to track the scaphoid during Percutaneous Scaphoid Fixation. In this study, ultrasound data was collected from this transducer and streamed to MATLAB, where an in-house developed algorithm employed template matching methods to track the scaphoid, specifically by identifying image segments that match a predefined template. With this method, we were able to demonstrate online processing at a frame rate of 28 Hz, which aligns with most clinical scanners, indicating the potential of this scaphoid tracking method for deployment on a clinical scanner.
经皮舟状骨固定术是一种微创技术,用于治疗舟状骨骨折,舟状骨是腕部骨折最多的骨。该手术的一个重大挑战是处理手腕运动引起的舟状骨运动并发症。本研究旨在通过引入一种新型可穿戴超声阵列来提高干预的有效性,该阵列能够灵活粘附和实时跟踪。通过在整个手术过程中精确监测舟状骨的运动,这项创新旨在提高治疗的整体成功率。在之前的研究中,设计了一种可穿戴传感器,用于在经皮舟状骨固定期间跟踪舟状骨。在本研究中,从该换能器收集超声数据并传输到MATLAB中,在MATLAB中,内部开发的算法采用模板匹配方法来跟踪舟状骨,特别是通过识别与预定义模板匹配的图像片段。通过这种方法,我们能够以28 Hz的帧率演示在线处理,这与大多数临床扫描仪一致,表明这种舟状骨跟踪方法在临床扫描仪上部署的潜力。
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引用次数: 0
Evaluation of a Dual Linear Flexible Ultrasound Array for Surgical Interventional Guidance 双线性柔性超声阵列对外科介入引导的评价
Pub Date : 2025-04-15 DOI: 10.1109/OJUFFC.2025.3560938
Hasti Rostamikhanghahi;Marcus Ingram;Brian G. Booth;Jan D’Hooge
Scaphoid fractures, the most common of wrist bone fractures, are typically treated using Percutaneous Scaphoid Fixation (PSF). Incorporating ultrasound guidance into this technique could reduce reliance on fluoroscopy, thereby avoiding ionizing radiation and improving procedural accuracy. However, the scaphoid’s position can shift as a result of hand movement during PSF, adding complexity to the procedure. Real-time ultrasound motion tracking of the scaphoid during PSF could simplify the intervention, which would necessitate a flexible transducer array to maintain contact during wrist motion. Our previous research proposed a transducer design with two parallel flexible 1D arrays, enabling simultaneous acquisition of two parallel images. This study focuses on transitioning from theoretical design to practical application by evaluating the performance of the custom array in terms of image quality using phantoms. We assessed image quality using the generalized contrast-to-noise ratio (gCNR) on a cyst phantom and the full width at half maximum (FWHM) on a wire phantom. Results demonstrated gCNR values above 0.67 and FWHM values below 0.70 mm across all sequences. These measurements fall within the acceptable range for the phantoms. Since the primary goal of the array is to track the scaphoid bone during surgery, requiring relatively high image quality, the values observed in this study are suitable for this application.
舟状骨骨折是最常见的腕骨骨折,通常采用经皮舟状骨固定(PSF)治疗。将超声引导纳入该技术可以减少对透视的依赖,从而避免电离辐射并提高程序准确性。然而,在PSF过程中,由于手部运动,舟状骨的位置可能会发生变化,这增加了手术的复杂性。PSF期间舟状骨的实时超声运动跟踪可以简化干预,这将需要一个灵活的传感器阵列来保持手腕运动期间的接触。我们之前的研究提出了一种具有两个平行柔性1D阵列的换能器设计,可以同时获取两个平行图像。本研究的重点是从理论设计过渡到实际应用,通过使用幻影评估自定义阵列在图像质量方面的性能。我们使用囊肿幻影的广义对比度-噪声比(gCNR)和线幻影的半最大全宽度(FWHM)来评估图像质量。结果表明,各序列gCNR值均大于0.67 mm, FWHM值均小于0.70 mm。这些测量值在幻影的可接受范围内。由于阵列的主要目的是在术中跟踪舟状骨,对图像质量要求较高,因此本研究中观察到的值适合于此应用。
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引用次数: 0
Optical Characteristics of an Ultrasound Gel Lens 超声凝胶透镜的光学特性
Pub Date : 2025-04-15 DOI: 10.1109/OJUFFC.2025.3561101
Haruto Miki;Fumiko Taniguchi;Kosuke Nakamura;Yuki Harada;Mami Matsukawa;Daisuke Koyama
Conventional camera modules are characterized by a substantial size, thickness, and weight. This is a consequence of the need for multiple lens elements to achieve the required level of image quality. However, as portable electronic devices continue to undergo miniaturization, there is a growing demand for smaller and thinner camera modules. In this paper, the optical characteristics of an ultrasound gel lens were evaluated quantitatively by expanding the wavefront of the transmitted light in terms of the Zernike polynomial. It was possible to control the focal length of the lens by changing its surface profile through the acoustic radiation force generated by ultrasonic vibration. The effects of ultrasound excitation on spherical aberration, coma aberrations, and astigmatisms were investigated. It was observed that spherical and coma aberrations increased with voltage amplitude, while astigmatism exhibited a reduction in magnitude.
传统相机模组的特点是尺寸、厚度和重量都很大。这是需要多个镜头元件来达到所需的图像质量水平的结果。然而,随着便携式电子设备的不断小型化,对更小更薄的相机模块的需求也在不断增长。本文利用Zernike多项式对透射光的波前展开,定量评价了超声凝胶透镜的光学特性。利用超声振动产生的声辐射力,通过改变透镜的表面轮廓来控制透镜的焦距。研究了超声激发对球面像差、彗差和像散的影响。球差和彗差随电压幅值增大而增大,而像散随电压幅值减小而减小。
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引用次数: 0
VisR Ultrasound Improves Diagnosis of Breast Cancer by the Elastogram-to-B-Mode Ratio in a Blinded Reader Study 在盲法读者研究中,VisR超声通过弹性图与b模式比提高乳腺癌的诊断
Pub Date : 2025-04-14 DOI: 10.1109/OJUFFC.2025.3560585
Anna V. Phillips;Cherie M. Kuzmiak;Gabriela Torres;Caterina M. Gallippi
Ultrasound elastography is increasingly being used alongside mammography for breast cancer diagnosis, particularly in women with radiographically dense breasts. The elastogram-to-B-Mode ratio (E/B), which compares lesion sizes in B-Mode and stiffness images, has been shown to differentiate malignant (E/B >1) from benign (E/B <1)>1 in malignant lesions and <1 in benign lesions) to those observed in stiffness images. Additionally, E/B values calculated from RE alone, RV alone, or a combination of RE and RV achieved 4-16% higher AUCs for discriminating malignant lesions compared to E/B derived solely from Acoustic Radiation Force Impulse (ARFI) peak displacement. These results suggest that incorporating VisR-derived viscosity and elasticity metrics into E/B calculations could significantly improve diagnostic accuracy for breast cancer detection.
超声弹性成像越来越多地与乳房x线照相术一起用于乳腺癌诊断,特别是在乳房密度较高的女性中。弹性图-B-模比(E/B),比较B-模图像和刚度图像中的病变大小,已被证明可以区分恶性(E/B >1)和良性(恶性病变E/B 1,良性病变E/B 1 <1)与刚度图像中观察到的病变。此外,与单独使用声辐射力脉冲(ARFI)峰值位移计算的E/B值相比,单独使用RE、RV或联合使用RE和RV计算的E/B值在鉴别恶性病变方面的auc高出4-16%。这些结果表明,将visr衍生的粘度和弹性指标纳入E/B计算可以显着提高乳腺癌检测的诊断准确性。
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引用次数: 0
Defect Orientation Evaluation in Structural Plates Using Reflective Correlation Indexing 基于反射相关索引的结构板缺陷定位评价
Pub Date : 2025-04-01 DOI: 10.1109/OJUFFC.2025.3556974
Ambuj K. Gautam;Ching-Chung Yin;Bishakh Bhattacharya
The fundamental shear horizontal (SH0) modes exhibit conversion behaviors to higher mode (SH1) influenced by the symmetric and anti-symmetric defects within a plate. Specifically, reflected SH0 modes remain unaffected by symmetrically oriented defects while transitioning to SH1 mode in the presence of anti-symmetrically oriented defects. This prompts inquiry into the effects when defects lie between symmetric and anti-symmetric positions within the plate thickness. In order to quantify the impact of mode conversion resulting from diverse defect orientations, a thorough analysis has been conducted, and a methodology has been proposed to assess the defect’s position using mode conversion of shear horizontal (SH) guided waves. Particularly, as defects move from symmetric to anti-symmetric positions, the energy of the reflected wave is notably influenced by the defect’s orientation. This indicates that defects located close to symmetric orientations yield minimal reflected energy in the converted SH1 mode, whereas those approaching anti-symmetric orientations exhibit significant reflected energy in the converted SH1 mode. To precisely identify the defect’s position, an assessment of the Reflective Correlation Indexing (RCI) of the converted mode has been conducted. Numerical simulations have been performed to investigate these phenomena and validated with an experimental result using chevron EMAT.
受板内对称和反对称缺陷的影响,基剪水平模态(SH0)表现出向高模态(SH1)的转换行为。具体来说,反射SH0模式不受对称取向缺陷的影响,而在存在反对称取向缺陷的情况下过渡到SH1模式。这促使人们探究当缺陷位于板厚内的对称和反对称位置之间时的影响。为了量化由不同缺陷方向引起的模态转换的影响,进行了深入的分析,并提出了一种使用剪切水平(SH)导波的模态转换来评估缺陷位置的方法。特别是,当缺陷从对称位置移动到反对称位置时,反射波的能量受到缺陷方向的显著影响。这表明,接近对称取向的缺陷在转换SH1模式下产生的反射能量最小,而接近反对称取向的缺陷在转换SH1模式下产生的反射能量显著。为了准确地识别缺陷的位置,对转换模式的反射相关索引(RCI)进行了评估。本文对这些现象进行了数值模拟,并与实验结果进行了验证。
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引用次数: 0
Small-Signal Equivalent Circuit Model of Long Rectangular CMUT Membranes 长矩形CMUT膜的小信号等效电路模型
Pub Date : 2025-03-20 DOI: 10.1109/OJUFFC.2025.3571698
Eric B. Dew;Shayan Khorassany;Mahyar Ghavami;Mohammad Rahim Sobhani;Mohammad Maadi;Roger J. Zemp
Capacitive micromachined ultrasound transducers (CMUTs) are typically designed with many small membranes per linear array element. However, these membranes can operate out of phase or collapse at different voltages, leading to suboptimal transmit performance and unreliable operation. To avoid these problems, we recently proposed a CMUT architecture with a single large rectangular membrane per element and novel insulated electrode post structures. These single-membrane CMUTs outperformed comparable piezoelectric transducers by almost 3-fold in terms of output pressure and demonstrated electromechanical efficiency values as high as 0.95. In this paper, we present an analytical model which can be used to simulate and optimize single-membrane rectangular CMUTs with or without post structures. Our approach relies on a polynomial deflection model, which was used to derive lumped element model parameters. Using this method, we developed expressions to model both electrostatic and pre-collapse small-signal dynamic CMUT behavior. This modeling framework was incorporated into a MATLAB program. We validated our approach using finite element method (FEM) simulations and experimental results in both air and immersion media. Model predictions for collapse voltage and operating frequency are within 4% of FEM results in both air and immersion. However, the runtime of our MATLAB program was 6 orders of magnitude faster than the corresponding FEM simulations. Compared with experiment, collapse voltage predictions were within 8%, and operating frequency predictions were within 5% in air and 18% in soybean oil. Our results indicate that that rectangular CMUTs may be optimized much further, potentially enabling even greater improvements over piezoelectric transducers.
电容式微机械超声换能器(CMUTs)通常在每个线性阵列元件上设计许多小膜。然而,这些膜可以在不同的电压下失相或崩溃,导致传输性能不理想和不可靠的运行。为了避免这些问题,我们最近提出了一种CMUT架构,每个元件都有一个大的矩形膜和新颖的绝缘电极柱结构。这些单膜CMUTs在输出压力方面比同类压电换能器性能高出近3倍,机电效率值高达0.95。在本文中,我们提出了一个解析模型,可用于模拟和优化单膜矩形CMUTs有或没有后结构。我们的方法依赖于一个多项式挠度模型,该模型用于导出集总单元模型参数。利用这种方法,我们开发了表达式来模拟静电和崩溃前的小信号动态CMUT行为。将该建模框架整合到MATLAB程序中。我们在空气和浸没介质中使用有限元方法(FEM)模拟和实验结果验证了我们的方法。在空气和浸没条件下,模型预测的崩溃电压和工作频率都在有限元计算结果的4%以内。然而,我们的MATLAB程序的运行时间比相应的FEM模拟快6个数量级。与实验相比,在空气和大豆油中,崩溃电压预测值在8%以内,工作频率预测值在5%以内。我们的研究结果表明,矩形CMUTs可以进一步优化,可能比压电换能器有更大的改进。
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引用次数: 0
Contactless Respiratory Waveform Estimation Using Ultrasound Planar Array 基于超声平面阵列的非接触式呼吸波形估计
Pub Date : 2025-03-17 DOI: 10.1109/OJUFFC.2025.3552048
Geng-Shi Jeng;Sheng Chen;Le-Tung Hsieh;Men-Tzung Lo
Accurate and contactless respiratory monitoring is essential for both clinical diagnostics and home healthcare, offering the potential for continuous, non-invasive observation. Ultrasound-based systems, particularly when integrated into home smart devices, provide a cost-effective solution. However, existing approaches are limited by poor directivity, inadequate clothing penetration, reliance on averaged respiratory rates without waveform details, and the inability to measure range due to continuous-wave Doppler techniques. To address these challenges, this study develops a novel 18-kHz, 16-channel two-dimensional (2-D) ultrasound array system employing adaptive beamforming to enhance sensitivity and accuracy in respiratory waveform detection. The system integrates pulsed and frequency-modulated continuous-wave (FMCW) excitation to improve the signal-to-noise ratio (SNR) by 20 dB, while the 2-D beamforming technique directly estimates delays from respiratory movements, boosting SNR by an additional 8.5 dB and eliminating the need for time-intensive volumetric scanning. Experimental results demonstrate sub-millimeter displacement accuracy in motor-controlled plate tests, surpassing wearable inertial measurement devices, and human trials reveal an average respiratory rate error of 0.13 breaths per minute across various clothing types and distances. The proposed system not only advances remote respiratory monitoring but also paves the way for enhanced health diagnostics in both clinical and home settings.
准确和非接触式呼吸监测对于临床诊断和家庭医疗保健都是必不可少的,它提供了持续、非侵入性观察的潜力。基于超声波的系统,特别是集成到家庭智能设备中时,提供了一种经济高效的解决方案。然而,现有的方法受到指向性差、衣服穿透力不足、依赖平均呼吸率而没有波形细节以及由于连续波多普勒技术而无法测量范围的限制。为了解决这些挑战,本研究开发了一种新的18khz, 16通道二维(2-D)超声阵列系统,采用自适应波束形成来提高呼吸波形检测的灵敏度和准确性。该系统集成了脉冲和调频连续波(FMCW)激励,将信噪比(SNR)提高了20 dB,而二维波束形成技术直接估计呼吸运动的延迟,将信噪比提高了8.5 dB,并且无需进行耗时的体积扫描。实验结果表明,在电机控制板测试中,亚毫米位移精度超过可穿戴惯性测量设备,人体试验表明,在不同服装类型和距离下,平均呼吸频率误差为每分钟0.13次。提出的系统不仅推进了远程呼吸监测,而且为增强临床和家庭环境中的健康诊断铺平了道路。
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引用次数: 0
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IEEE open journal of ultrasonics, ferroelectrics, and frequency control
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