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Effect of yoga intervention on skeletal muscle linked glucose homeostasis in pre-diabetic individuals: Study protocol for a randomized controlled trial 瑜伽干预对糖尿病前期个体骨骼肌相关葡萄糖稳态的影响:随机对照试验的研究方案
IF 1.7 Q2 Medicine Pub Date : 2022-12-01 DOI: 10.1016/j.aimed.2022.11.002
Supriya Bhalerao , Jayshree Kharche , Shubhangi Harke

Background

The pre-diabetic stage is important in terms of identification and timely management due to its reversible nature. Along with other factors, insulin resistance in skeletal muscle is often considered as primary defect before development of overt hyperglycemia and Diabetes Mellitus (DM). Physical exercises are beneficial in prevention of DM by improving skeletal muscle mediated glucose metabolism. Evidence suggests that Yoga interventions appear to be equal and/or superior to exercise in most outcome measures. As the Yogic postures are relatable to exercises, they are considered to improve skeletal muscle function and reverse the pre-diabetic stage.

Methods

This open-labelled, randomized clinical study is planned to evaluate effect of Yoga interventions on muscle mass, strength, endurance and flexibility which are direct/indirect indicators of fat deposition in skeletal muscles. Association between changes in muscle quality/ functionality and glycemic control will also be explored. With ethics committee permission, 120 pre-diabetic individuals of either sex between age group of 35–49 years with BMI range of 25–35 kg/m2 and family history of Type 2 Diabetes Mellitus (T2DM) will be recruited after obtaining written informed consent. They will be randomly allocated to either Yoga or exercise group by computer generated randomized method in a 1:1 ratio. One group will receive defined Yoga interventions, while other group will receive fixed program of physical exercises. Prior to initiating this 12-week study, both groups will undergo a training session for 4 weeks under supervision of a trained instructor. The outcome measures will be parameters related to muscle quality/functionality and glucose metabolism markers.

Discussion

Our study aims to explore practicality of Yoga in pre-diabetic stage on skeletal muscle related glycemic control, which is novel. Additionally, the study will generate awareness about pre-diabetes and provide people with active coping skills for reversing it.

糖尿病前期由于其可逆性,在识别和及时管理方面具有重要意义。与其他因素一起,骨骼肌的胰岛素抵抗通常被认为是发展为显性高血糖和糖尿病(DM)之前的原发性缺陷。体育锻炼通过改善骨骼肌介导的葡萄糖代谢,有助于预防糖尿病。有证据表明,在大多数结果测量中,瑜伽干预似乎与运动相同或优于运动。由于瑜伽姿势与运动相关,它们被认为可以改善骨骼肌功能并逆转糖尿病前期。方法本开放标签随机临床研究旨在评估瑜伽干预对骨骼肌脂肪沉积的直接/间接指标肌肉质量、力量、耐力和柔韧性的影响。还将探讨肌肉质量/功能变化与血糖控制之间的关系。经伦理委员会许可,在获得书面知情同意后,将招募年龄在35-49岁、BMI在25-35 kg/m2之间、有2型糖尿病(T2DM)家族史的120名糖尿病前期患者,不限性别。通过计算机生成的随机方法,将他们按1:1的比例随机分配到瑜伽组和运动组。一组将接受明确的瑜伽干预,而另一组将接受固定的体育锻炼计划。在开始这项为期12周的研究之前,两组都将在一位训练有素的指导员的监督下接受为期4周的培训。结果测量将是与肌肉质量/功能和葡萄糖代谢标志物相关的参数。本研究旨在探讨糖尿病前期瑜伽对骨骼肌相关血糖控制的实用性,是一项新颖的研究。此外,这项研究将提高人们对糖尿病前期的认识,并为人们提供积极的应对技能来扭转它。
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引用次数: 0
Breathing-based meditation (Sudarshan Kriya Yoga) increases sense of coherence. No-cost stress prevention 以呼吸为基础的冥想(苏达山克里亚瑜伽)增加了连贯性。无成本应力预防
IF 1.7 Q2 Medicine Pub Date : 2022-12-01 DOI: 10.1016/j.aimed.2022.11.001
Agnieszka Banaś-Ząbczyk , Paweł Jakubczyk , Barbara Pikuła , Anna Sendera , Marta Kopańska

Background and aim

Our society deals with multiple challenges such as psychological stress, anxiety, and depression, as well as disasters, crises including the pandemic crisis, and the current war. Excess stress can manifest itself in a variety of emotional, behavioral, and even physical symptoms, which strongly correlate with deterioration of health and a decrease in quality of life. Sense of coherence (SOC) is a central pillar of Antonovsky’s salutogenic model of health and it is focused on the relationship between health, stress, and coping. The SOC scale comprises the evaluation of the sense of comprehensibility (SC), the sense of manageability (SM), and the sense of meaningfulness (SMF), which are associated with both physical and psychological health.

Methods

The Mind-Body Medicine intervention breathing-based meditation (SKY-Sudarshan Kriya Yoga) was evaluated to assess its impact on the sense of coherence of practitioners in a pilot trial. The study groups consisted of 132 practitioners of SKY during the Youth Empowerment Seminar (YES!+) and 128 not participating/not practicing (260 in total). Both groups filled out SOC-29 questionnaire twice, on day first and sixth. Based on the SOC-29 test, SOC, SC, SM, and SMF have been evaluated in both groups.

Results and conclusion

Experience with the SKY breathing technique showed a statistically significant (p < 0.05) increase of the sense of coherence of practitioners. Also, the senses of comprehensibility, manageability, and meaningfulness increased by 12%. The SKY exercise does not require any additional preparation, or equipment and may present a no-cost solution to help deal with stress and life demands.

我们的社会面临着多重挑战,如心理压力、焦虑和抑郁,以及灾难、危机,包括大流行危机和当前的战争。过度的压力可以表现为各种情绪、行为甚至身体症状,这些症状与健康状况的恶化和生活质量的下降密切相关。和谐感(SOC)是安东诺夫斯基健康健康模型的核心支柱,它关注健康、压力和应对之间的关系。SOC量表包括对可理解感(SC)、可管理感(SM)和意义感(SMF)的评估,它们与生理和心理健康相关。方法对身心医学干预呼吸冥想(SKY-Sudarshan Kriya Yoga)进行评估,以评估其对练习者连贯感的影响。研究小组由132名青年赋权研讨会(YES!+)的SKY实践者和128名未参加/未实践的人组成(共260人)。两组在第一天和第六天分别填写了两次SOC-29问卷。基于SOC-29测试,对两组的SOC、SC、SM和SMF进行了评估。结果与结论:SKY呼吸技术的经验显示有统计学意义(p <0.05)从业人员的连贯性意识增加。此外,可理解性、可管理性和意义感也提高了12%。SKY演习不需要任何额外的准备或设备,并且可能提供一种无成本的解决方案来帮助应对压力和生活需求。
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引用次数: 1
Balancing promoting the public’s right to traditional, complementary and integrative health with evidence-based health care 在促进公众获得传统、补充和综合保健的权利与循证保健之间取得平衡
IF 1.7 Q2 Medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.07.001
Jon Wardle
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引用次数: 2
Chronic plaque psoriasis treated with topical Unani formulation Marham Ḥina – A series of case reports 慢性斑块型银屑病治疗局部Unani制剂Marham Ḥina -一系列病例报告
IF 1.7 Q2 Medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.06.005
Faiza Khatoon , Arzeena Jabeen , Qamar Uddin , Nazim Husain , Mohd Azahar , Md Sanaul Moin

Background

Although psoriasis treatment has advanced significantly in recent years, the disease remains incurable and relapsing. Alternatively, several potent systemic and topical formulations have been described in the Unani (Greco-Arab) system of medicine for conditions clinically similar to psoriasis, but there is a dearth of scientific evidence.

Aim

The purpose of this study was to investigate the efficacy and safety of the Unani formulation Marham Ḥina in chronic plaque psoriasis.

Methods

Seven patients with chronic plaque psoriasis, were treated with Marham Ḥina for 12 weeks.

Results

The mean ± SD of the psoriasis area and severity index (PASI) was significantly decreased from 24.00 ± 10.18 at baseline to 2.00 ± 1.29. One case attained PASI 100, two cases attained PASI 95, another two cases attained PASI 90, and the remaining two cases attained PASI 75.

Conclusion

The trial formulation appears to have a strong anti-psoriatic effect, while posing no adverse effects. However, more precise prospective clinical studies are recommended to confirm its scientific validity

背景:尽管近年来银屑病的治疗取得了显著进展,但这种疾病仍然无法治愈并会复发。另外,在Unani(希腊-阿拉伯)医学系统中,已经描述了几种有效的全身和局部配方,用于临床类似牛皮癣的病症,但缺乏科学证据。目的探讨Unani复方Marham Ḥina治疗慢性斑块型银屑病的疗效和安全性。方法对7例慢性斑块型银屑病患者采用Marham Ḥina治疗12周。结果银屑病面积及严重程度指数(PASI)均值±SD由基线时的24.00±10.18降至2.00±1.29。1例达到PASI 100, 2例达到PASI 95, 2例达到PASI 90,其余2例达到PASI 75。结论该制剂具有较强的抗银屑病作用,且无不良反应。然而,建议更精确的前瞻性临床研究来证实其科学有效性
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引用次数: 1
Effects of antioxidant supplement on immune health and physical wellbeing: A randomized, controlled trial 抗氧化剂补充对免疫健康和身体健康的影响:一项随机对照试验
IF 1.7 Q2 Medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.06.007
Jessie Hawkins, Christy Hires, Elizabeth Dunne, Lindsey Keenan

Background

Maintaining a healthy immune system came to the forefront of people’s minds as SARS-CoV-2 (COVID-19) was introduced. Antioxidants contained in dark berries have been shown to support the physical wellbeing of otherwise healthy adults. Adding a supplement rich in dark berries and citrus essential oils contributes antioxidants to the body and serves as an aid to reduce free radicals.

Aim

We evaluated the effects of an antioxidant rich supplement on immune health and overall physical wellbeing compared to a control group.

Method

Participants were otherwise healthy adults, aged 18–60 years old, and were placed in either the antioxidant supplement group or control group using adaptive randomization. Data was collected at day 1 and 60. The Physical Health Questionnaire was used to measure the primary outcomes of this study. The immune health was reflected through the Jackson Symptom Scale.

Results

155 participants were analyzed. Participants who consumed the antioxidant beverage saw improvements to overall health which dramatically exceeded those of the control group. The sleep domain produced improvements which represented disturbances in sleep habits as they pertain to general health. Those in the supplement group who reported illness, had illnesses lasting 1–2 days while those in the control group had illnesses lasting from 1 to 9 days.

Conclusion

Length of illness was shorter and sleep duration improved in the supplement group compared to the control group. Daily consumption of 60 ml of the antioxidant drink NingXia RedⓇ showed significant improvement after 60 days.

随着新冠肺炎(SARS-CoV-2)的出现,保持健康的免疫系统成为人们关注的焦点。黑莓中含有的抗氧化剂已被证明对健康成年人的身体健康有益。添加富含黑莓和柑橘精油的补充剂有助于身体抗氧化剂,并有助于减少自由基。与对照组相比,我们评估了富含抗氧化剂的补充剂对免疫健康和整体身体健康的影响。方法参与者为18-60岁的健康成年人,采用适应性随机分组法分为抗氧化剂补充组和对照组。在第1天和第60天收集数据。采用体质健康问卷来衡量本研究的主要结果。通过Jackson症状量表反映免疫健康状况。结果对155名参与者进行了分析。饮用抗氧化饮料的参与者的整体健康状况明显优于对照组。睡眠领域产生了改善,这代表了睡眠习惯的紊乱,因为它们与一般健康有关。那些服用补充剂的人患病持续1 - 2天而对照组的人患病持续1 - 9天。结论与对照组相比,补充组患者病程缩短,睡眠时间延长。每天饮用60毫升的抗氧化饮料宁夏红Ⓡ,60天后效果显著改善。
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引用次数: 1
The effects of a 12-week yoga intervention on body awareness in people with multiple sclerosis: A non-controlled pilot study 12周瑜伽干预对多发性硬化症患者身体意识的影响:一项非对照的初步研究
IF 1.7 Q2 Medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.06.001
Signe Reitzel Gunnersen , Kirsten Hanehøj , Signe Gro , Clara Mosborg Petersen , Lasse Skovgaard

Introduction and objective

Multiple sclerosis is a neurological autoimmune disease. Different disease-modifying treatments exist; however, they do not control the neurodegenerative processes and often result in adverse events. Therefore, many people with multiple sclerosis turn to complementary or integrative health (CIH) practices. Yoga is one of the more popular CIH practices among people with multiple sclerosis, and evidence points to an association between yoga and improved body awareness. The objective of this study was to investigate if a 12-week yoga course can improve body awareness in patients with multiple sclerosis as measured with the Multidimensional Assessment of Interoceptive Awareness (MAIA) questionnaire.

Material and methods

In this non-controlled pilot study, 22 patients participated in a 12-week yoga course. They attended weekly classes with the instructor and were encouraged to practice the exercises at home twice weekly. Before and after the course, all participants filled in the MAIA questionnaire, which consists of the eight dimensions: Noticing, Not-distracting, Not-Worrying, Attention regulation, Emotional awareness, Self-regulation, Body-listening and Trusting. Changes in mean scores were estimated with two-tailed paired t-tests.

Results

After the 12-week yoga course, participants’ total mean scores for body awareness improved significantly. Significant improvements were detected within three of the eight subscales from the MAIA, Attention regulation, Emotional awareness and Trusting.

Conclusion

The results of this non-controlled pilot study suggest that yoga may have a positive effect on body awareness in patients with multiple sclerosis. Improvements were found in all subscales of body awareness although only improvements in three of the eight subscales were significant.

简介与目的多发性硬化症是一种神经系统自身免疫性疾病。存在不同的疾病改善疗法;然而,它们不能控制神经退行性过程,并经常导致不良事件。因此,许多多发性硬化症患者转向补充或综合健康(CIH)实践。瑜伽是多发性硬化症患者中比较流行的CIH练习之一,有证据表明瑜伽和提高身体意识之间存在联系。本研究的目的是调查为期12周的瑜伽课程是否可以改善多发性硬化症患者的身体意识,并通过多维内感受性意识评估(MAIA)问卷进行测量。材料和方法在这项非对照的初步研究中,22名患者参加了为期12周的瑜伽课程。他们每周跟随教练上课,并被鼓励每周在家练习两次。课程前后,所有参与者均填写了MAIA问卷,该问卷由注意、不分心、不担忧、注意力调节、情绪意识、自我调节、身体倾听和信任八个维度组成。用双尾配对t检验估计平均得分的变化。结果经过12周的瑜伽课程后,参与者身体意识的总平均分显著提高。在MAIA的八个子量表中,注意调节、情绪意识和信任的三个子量表中发现了显著的改善。结论这项非对照的初步研究结果表明,瑜伽可能对多发性硬化症患者的身体意识有积极作用。身体意识的所有子量表都有改善,尽管八个子量表中只有三个有显著的改善。
{"title":"The effects of a 12-week yoga intervention on body awareness in people with multiple sclerosis: A non-controlled pilot study","authors":"Signe Reitzel Gunnersen ,&nbsp;Kirsten Hanehøj ,&nbsp;Signe Gro ,&nbsp;Clara Mosborg Petersen ,&nbsp;Lasse Skovgaard","doi":"10.1016/j.aimed.2022.06.001","DOIUrl":"10.1016/j.aimed.2022.06.001","url":null,"abstract":"<div><h3>Introduction and objective</h3><p><span><span>Multiple sclerosis is a neurological autoimmune disease. Different disease-modifying </span>treatments exist; however, they do not control the neurodegenerative processes and often result in adverse events. Therefore, many people with multiple sclerosis turn to complementary or integrative health (CIH) practices. Yoga is one of the more popular CIH practices among people with multiple sclerosis, and evidence points to an association between yoga and improved body awareness. The objective of this study was to investigate if a 12-week yoga course can improve body awareness </span>in patients with multiple sclerosis as measured with the Multidimensional Assessment of Interoceptive Awareness (MAIA) questionnaire.</p></div><div><h3>Material and methods</h3><p>In this non-controlled pilot study, 22 patients participated in a 12-week yoga course. They attended weekly classes with the instructor and were encouraged to practice the exercises at home twice weekly. Before and after the course, all participants filled in the MAIA questionnaire, which consists of the eight dimensions: Noticing, Not-distracting, Not-Worrying, Attention regulation, Emotional awareness, Self-regulation, Body-listening and Trusting. Changes in mean scores were estimated with two-tailed paired t-tests.</p></div><div><h3>Results</h3><p>After the 12-week yoga course, participants’ total mean scores for body awareness improved significantly. Significant improvements were detected within three of the eight subscales from the MAIA, Attention regulation, Emotional awareness and Trusting.</p></div><div><h3>Conclusion</h3><p>The results of this non-controlled pilot study suggest that yoga may have a positive effect on body awareness in patients with multiple sclerosis. Improvements were found in all subscales of body awareness although only improvements in three of the eight subscales were significant.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"9 3","pages":"Pages 167-172"},"PeriodicalIF":1.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85531523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of an on-campus herb garden in facilitating teaching and learning for students enroled in a naturopathic and herbal medicine degree 校园草药园在促进自然疗法和草药学位学生教学中的作用
IF 1.7 Q2 Medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.06.003
Asmita Patel, Wayne Hill, Karen Wesseling, Karen Mees, Robyn Carruthers, Clive Standen

Objectives

The educational role of elementary/primary school gardens for school-aged children has been well-researched and documented. Within tertiary education, limited published research exists regarding the role that on-campus gardens have as a practical teaching resource for the learning of degree curriculum. Therefore, the aim of the present study was to ascertain the role that an extensive on-campus herb garden had in facilitating teaching and learning for students enroled in a naturopathic and herbal medicine degree.

Methods

Twenty-one students enroled in a naturopathy and herbal medicine degree at a naturopathic college in Auckland, New Zealand were individually interviewed. Data was analysed using an inductive thematic approach.

Results

A number of themes and subthemes were identified. The on-campus herb garden provided students with ongoing access to a wide range of herbs and plants that are not readily accessible in the wider community. The herb garden acted as a practical resource for teaching and learning, as it aided coursework by providing students with salient opportunities for practical learning, which included the manufacturing of products for assessments. The direct physical interaction that the herb garden provided, was perceived by students as taking their learning of course material to a level beyond what a textbook could provide. The herb garden provided sensory/kinaesthetic learning opportunities, which were perceived to aid student learning. Students also utilised the herb garden for the acquisition of herbs for food and tea consumption, including the preparation of tea to provide to clients in the student clinic.

Conclusions

The present study provided qualitative insights from students regarding the salient role and multiple ways in which an extensive on-campus herb garden supported and aided their learning within a naturopathic and herbal medicine degree curriculum.

目的对小学/小学花园对学龄儿童的教育作用进行了充分的研究和记录。在高等教育中,关于校园花园作为学位课程学习的实用教学资源的作用,发表的研究有限。因此,本研究的目的是确定一个广泛的校园草药园在促进自然疗法和草药学位学生的教学和学习方面的作用。方法对新西兰奥克兰一所自然疗法学院自然疗法和草药医学专业的21名学生进行单独访谈。数据分析采用归纳专题方法。结果确定了若干主题和副主题。校园内的草药花园为学生提供了持续接触各种草药和植物的机会,这些草药和植物在更广泛的社区中是不容易接触到的。草药园作为教学和学习的实用资源,因为它通过为学生提供实践学习的突出机会来辅助课程,其中包括制造用于评估的产品。香草园所提供的直接物理互动,被学生们认为是将他们的学习材料提升到教科书所不能提供的水平。香草园提供了感官/动觉学习的机会,这被认为有助于学生的学习。学生们还利用草药园获取草药用于食品和茶的消费,包括准备茶提供给学生诊所的客户。本研究从学生那里提供了定性的见解,了解了广泛的校园草药园在支持和帮助他们在自然疗法和草药学位课程中学习的突出作用和多种方式。
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引用次数: 3
Efficacy of the barley-based remedy, a Persian medicine formula, in coronavirus disease 2019 (COVID-19) hospitalized patients: An open-labeled randomized controlled trial 以大麦为基础的波斯药物配方对2019冠状病毒病(COVID-19)住院患者的疗效:一项开放标签随机对照试验
IF 1.7 Q2 Medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.04.001
Fatemeh Sadat Hasheminasab , Maryam Azimi , Mahmood Khodadoost , Bahram Chouban , Nezhat Shakeri , Saeedeh Ghasemi , Azam Farokhi , Roshanak Mokaberinajad

Background

With the pandemic of coronavirus disease 2019 (COVID-19), and the growing attention of people around the world to the use of traditional and complementary medicines to control of the disease, evaluating the effectiveness of these treatments has received special attention.

Aim

This study aimed to assess the clinical efficacy of a barley-based (Hordeum vulgare) remedy combined with conventional medicine in comparison to the conventional therapy in confirmed COVID-19 patients.

Materials and methods

Seventy COVID-19 patients were randomly divided into barley-based remedy plus conventional medicine (barley-based remedy group) and conventional therapy (control group). Both groups were treated for 5 days. The outcomes were oxygen saturation, main symptoms (fever, respiratory rate, cough, and fatigue), and laboratory data (lymphocytic count, and CRP); they were measured for 6 days.

Results

In comparison to the control group, the oxygen saturation level in the barley-based remedy group significantly increased, from the second day of the intervention (P < 0.05). The herbal remedy significantly improved fatigue from the third day (P < 0.05). Meanwhile, the severity and frequency of cough between the groups were not significantly different. The herbal remedy had no significant effect on the CRP and the lymphocytic count of every time points of measurement. The average of respiratory rate and temperature of patients were in the normal range in both groups during the intervention.

Conclusion

Barley-based remedy could significantly enhance the blood oxygen saturation and reduce fatigue. However, it needs to be confirmed by large sample size trials.

随着2019年冠状病毒病(COVID-19)的大流行,以及世界各地人们越来越关注使用传统和补充药物来控制疾病,评估这些治疗方法的有效性受到了特别关注。目的评价以大麦为基础的中药联合常规药物治疗新冠肺炎确诊患者的临床疗效。材料与方法将70例COVID-19患者随机分为大麦方加常规药物组(大麦方组)和常规治疗组(对照组)。两组均治疗5 d。结果包括血氧饱和度、主要症状(发热、呼吸频率、咳嗽和疲劳)和实验室数据(淋巴细胞计数和CRP);随访6天。结果与对照组相比,大麦基疗法组患者血氧饱和度从干预第2天起显著升高(P <0.05)。该药从第3天起显著改善疲劳(P <0.05)。同时,两组患者咳嗽的严重程度和频率无显著差异。中药对CRP及各时间点淋巴细胞计数无明显影响。干预期间两组患者呼吸频率和体温均在正常范围内。结论大麦汤能明显提高血氧饱和度,减轻疲劳。然而,这需要通过大样本量的试验来证实。
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引用次数: 2
Safety and tolerability of Pau d′ Arco (Tabebuia avellanedae) for primary dysmenorrhea: A single-arm, open-label trial on adults ages 18–45 Pau d ' Arco (Tabebuia avellanedae)治疗原发性痛经的安全性和耐受性:一项针对18-45岁成年人的单臂、开放标签试验
IF 1.7 Q2 Medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.04.003
C. McClure , M. Bollen , L. Buttolph , E. Stack , B.O. Langley , D. Hanes , K.M. Wright , D. Tibbitts , R. Bradley

Objectives

To evaluate the safety and tolerability of encapsulated Tabebuia avellanedae in generally healthy women aged 18–45 with primary dysmenorrhea.

Methods

A single arm, open-label trial was conducted in which 1050 mg/day of encapsulated Tabebuia avellanedae (Pau d′Arco) was administered to twelve healthy women aged 18–45 for eight weeks. The primary outcome was safety and tolerability as measured by standardized adverse events scales and serial collection of laboratory markers to assess general health, prothrombin times, and the presence or absence of anemia. Secondary outcomes included pain intensity, quality of life, and pain interference measured by the Visual Analog Scale (VAS), the Patient-Reported Outcomes Measurement Information System (PROMIS) 29 survey, and the PROMIS Visual Sexual Function and Satisfaction: Interfering Factors survey, respectively. Exploratory outcomes included serum concentration of high-sensitivity C-reactive protein as a marker of systemic inflammation.

Results

Seventy-five percent of participants (n = 9/12) completed the study. Seventy-five percent of study participants (n = 9/12) reported an adverse event, most of which were characterized as mild, and none were determined to be a Food and Drug Administration (FDA) serious adverse event. Most laboratory markers stayed within normal limits throughout the study period with a few clinically mild abnormalities. There was a significant decrease in pain intensity compared to baseline after the first dose (p < .01), after 4 weeks of treatment (p < .01), and after 8 weeks of treatment (p < .01). Over the 8-week intervention period, pain interference, quality of life, and sexual function and satisfaction scores improved nonsignificantly and hs-CRP decreased nonsignificantly.

Conclusions

Tabebuia avellanedae supplementation of 1050 mg/day dose for eight weeks in generally healthy women aged 18–45 with primary dysmenorrhea was generally safe, associated with moderate tolerability, and associated with significant improvements in pain intensity scores. Future studies examining the safety and efficacy of Tabebuia avellanedae on primary dysmenorrhea are warranted.

目的评价胶囊化阿韦兰他布亚在18-45岁原发性痛经女性患者中的安全性和耐受性。方法采用单臂、开放标签试验,对12名年龄在18-45岁的健康女性,给予1050 mg/d胶囊化阿韦兰他布亚(Pau d’arco),持续8周。主要结局是安全性和耐受性,通过标准化不良事件量表和实验室标志物的系列收集来评估一般健康状况、凝血酶原时间和贫血的存在或不存在。次要结果包括疼痛强度、生活质量和疼痛干扰,分别由视觉模拟量表(VAS)、患者报告结果测量信息系统(PROMIS) 29调查和PROMIS视觉性功能和满意度:干扰因素调查测量。探索性结果包括作为全身性炎症标志的高敏c反应蛋白的血清浓度。75%的参与者(n = 9/12)完成了研究。75%的研究参与者(n = 9/12)报告了不良事件,其中大多数是轻微的,没有一个被确定为食品和药物管理局(FDA)的严重不良事件。大多数实验室标志物在整个研究期间保持在正常范围内,只有少数临床轻度异常。与基线相比,第一次给药后疼痛强度显著降低(p <.01),治疗4周后(p <.01),治疗8周后(p <. 01)。在8周的干预期内,疼痛干扰、生活质量、性功能和满意度评分无显著改善,hs-CRP无显著下降。结论对18-45岁原发性痛经的健康女性,补充1050 mg/天剂量,持续8周是安全的,具有中等耐受性,并与疼痛强度评分显著改善相关。未来研究他伯布亚治疗原发性痛经的安全性和有效性是有必要的。
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引用次数: 0
Increased hope levels correlate with life satisfaction in cancer patients: A systematic review 癌症患者生活满意度与希望水平的增加相关:一项系统综述
IF 1.7 Q2 Medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.06.002
Gunel Guliyeva , Antonio J. Forte , Heidi McLeod , Manisha Salinas , Francisco R. Avila , Adam I. Perlman

Introduction

Hope is an integral and essential part of the cancer journey. Its association with satisfaction has been described in previous studies. Measures to increase cancer patients’ levels of hope may contribute to the perception of an improvement in patient-centered healthcare delivery.

Methods

Four databases (Pubmed, Scopus, Embase, and CINAHL) were queried for relevant studies. The study inclusion criteria were limited to the peer-reviewed original research articles published in English.

Results

Four hundred seventy seven articles, published between 1911 and 2020, were found. Nine studies with different cancer populations met the inclusion criteria. A positive correlation between hope levels and life, marital, and information satisfaction was observed in all studies. Analysis of five studies that reported correlation coefficients showed a moderate correlation between hope and satisfaction with life.

Conclusion

The described relationship between hope and patient satisfaction should encourage the development of new techniques to increase hope levels in cancer patients to improve their satisfaction with the quality of healthcare delivery received. Future prospective studies are needed to evaluate the effectiveness of hope interventions on satisfaction levels in cancer patients. Reliability testing and comparison of current hope and satisfaction scales would allow for determining the “gold standard” scales and standardizing the research in this area.

希望是癌症治疗过程中不可或缺的一部分。在以前的研究中已经描述了它与满意度的关系。提高癌症患者希望水平的措施可能有助于改善以患者为中心的医疗保健服务。方法检索Pubmed、Scopus、Embase、CINAHL等数据库进行相关研究。研究纳入标准仅限于同行评议的英文原创研究文章。结果共发现477篇发表于1911年至2020年间的论文。涉及不同癌症人群的9项研究符合纳入标准。在所有研究中都观察到希望水平与生活、婚姻和信息满意度呈正相关。对报告相关系数的五项研究的分析显示,希望与生活满意度之间存在适度的相关性。结论希望与患者满意度之间的关系应鼓励新技术的发展,以提高癌症患者的希望水平,提高他们对医疗服务质量的满意度。未来的前瞻性研究需要评估希望干预对癌症患者满意度的有效性。目前的希望和满意量表的可靠性测试和比较将允许确定“金标准”量表,并使这一领域的研究标准化。
{"title":"Increased hope levels correlate with life satisfaction in cancer patients: A systematic review","authors":"Gunel Guliyeva ,&nbsp;Antonio J. Forte ,&nbsp;Heidi McLeod ,&nbsp;Manisha Salinas ,&nbsp;Francisco R. Avila ,&nbsp;Adam I. Perlman","doi":"10.1016/j.aimed.2022.06.002","DOIUrl":"10.1016/j.aimed.2022.06.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Hope is an integral and essential part of the cancer journey. Its association with satisfaction has been described in previous studies. Measures to increase cancer patients’ levels of hope may contribute to the perception of an improvement in patient-centered healthcare delivery.</p></div><div><h3>Methods</h3><p>Four databases (Pubmed, Scopus, Embase, and CINAHL) were queried for relevant studies. The study inclusion criteria were limited to the peer-reviewed original research articles published in English.</p></div><div><h3>Results</h3><p>Four hundred seventy seven articles, published between 1911 and 2020, were found. Nine studies with different cancer populations met the inclusion criteria. A positive correlation between hope levels and life, marital, and information satisfaction was observed in all studies. Analysis of five studies that reported correlation coefficients showed a moderate correlation between hope and satisfaction with life.</p></div><div><h3>Conclusion</h3><p>The described relationship between hope and patient satisfaction should encourage the development of new techniques to increase hope levels in cancer patients to improve their satisfaction with the quality of healthcare delivery received. Future prospective studies are needed to evaluate the effectiveness of hope interventions on satisfaction levels in cancer patients. Reliability testing and comparison of current hope and satisfaction scales would allow for determining the “gold standard” scales and standardizing the research in this area.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"9 3","pages":"Pages 145-150"},"PeriodicalIF":1.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88970689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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Advances in integrative medicine
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