Advances in integrative medicine最新文献_第7页

The effectiveness of herbal remedies in preventing striae gravidarum: A systematic review and meta-analysis 中药预防妊娠纹的有效性：一项系统回顾和荟萃分析

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-06-23 DOI: 10.1016/j.aimed.2025.100530

Masoumeh Razavi , Mojgan Mirghafourvand , Mahnaz Shahnazi , Khadije Hajizadeh

Background

Striae gravidarum is a common skin condition that affects approximately 60–90 % of pregnant women. This systematic review aimed to evaluate the effectiveness of herbal remedies in preventing stretch marks during pregnancy.

Methods

A comprehensive literature search was conducted in PubMed, Cochrane Library, Embase, Scopus, and SID databases for studies published between January 1972 and May 2024. Randomized controlled trials (RCTs) assessing the preventive effects of herbal remedies—including oils, creams, and plant-based extracts—on pregnant women were included. Data were analyzed using RevMan software, and meta-analysis was performed using fixed-effect or random-effects models based on the degree of heterogeneity. Subgroup analysis was performed based on the type of herbal remedies on incidence (primary outcome) and itching and erythema (secondary outcomes).

Results

A total of 12 randomized controlled trials involving 1956 pregnant women were included. Herbal treatments such as Aloe vera gel, sweet almond oil, and sesame oil showed a significant reduction in the incidence of stretch marks compared to placebo (12 studies, n = 1956; OR = 0.47, 95 % CI: 0.28–0.79, p = 0.004). In addition, four subgroup analyses from four distinct studies (n = 601) demonstrated that herbal products significantly reduced the incidence of itching compared to controls (OR = 0.09, 95 % CI: 0.03–0.30, p < 0.00001), while two studies (n = 139) showed a significant reduction in erythema incidence in the intervention groups (OR = 0.17, 95 % CI: 0.07–0.38, p < 0.0001).

Conclusion

Although some herbal remedies, especially Aloe vera, Sweet Almond oil and Sesame oil have high potential for the prevention and management of stretch marks, the heterogeneity in the studies' design and results indicates the need for more high-quality research.

背景：妊娠纹是一种常见的皮肤病，影响了大约60 - 90% %的孕妇。本系统综述旨在评估草药在怀孕期间预防妊娠纹的有效性。方法在PubMed、Cochrane Library、Embase、Scopus和SID数据库中检索1972年1月至2024年5月间发表的文献。随机对照试验（rct）评估了草药（包括油、面霜和植物提取物）对孕妇的预防作用。使用RevMan软件对数据进行分析，并根据异质性程度采用固定效应或随机效应模型进行meta分析。根据草药类型对发生率（主要结局）和瘙痒和红斑（次要结局）进行亚组分析。结果共纳入12项随机对照试验，涉及孕妇1956例。与安慰剂相比，芦荟凝胶、甜杏仁油和芝麻油等草药治疗显著降低了妊娠纹的发生率(12项研究，n = 1956；OR = 0.47, 95 % CI: 0.28-0.79, p = 0.004)。此外,四子群分析从四个不同的研究(n = 601)表明,草药产品显著降低发病率的瘙痒而控制(或= 0.09,95 % CI: 0.03 - -0.30, p & lt; 0.00001),而两项研究(n = 139)显示,红斑发生率显著减少干预组(或= 0.17,95 % CI: 0.07 - -0.38, p & lt; 0.0001)。结论虽然芦荟、甜杏仁油和芝麻油等一些草药在预防和治疗妊娠纹方面具有很大的潜力，但研究设计和结果的异质性表明需要更多高质量的研究。

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引用次数: 0

Inflammatory biomarkers modulation in postmenopausal women: A randomized controlled trial of the superiority of Co-supplementing curcumin nano-micelles and Nigella sativa 绝经后妇女的炎症生物标志物调节：一项随机对照试验，共同补充姜黄素纳米胶束和黑草的优势

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-06-18 DOI: 10.1016/j.aimed.2025.100528

Amir Mehdi Iranshahi , Mahdi Amirpour , Soraya Babaie , Azizeh Farshbaf-Khalili , Alireza Ostadrahimi

Background

Lasting inflammation, whether directly mediated by hormonal changes or induced by oxidative stress, has significant negative effects on bone health, potentially contributing to the development of postmenopausal osteopenia and osteoporosis. Anti-inflammatory herbal products, known for cost-effectiveness and safety, support bone remodeling. This study evaluates the efficacy of Curcumin Nano-micelles (CUR), Nigella sativa (NS), and their co-supplementation (NS-CUR) on serum inflammatory factors in postmenopausal women with osteopenia or osteoporosis.

Methods

A triple-blind randomized trial was conducted on 120 postmenopausal women. Patients were allocated to four groups stratified by bone density. During the 6-month intervention, the NS group took an NS oil capsule and a CUR placebo capsule daily. The CUR group consumed a CUR capsule and an NS placebo capsule daily. The NS-CUR group received a CUR capsule and an NS oil capsule daily. The placebo group received two microcrystalline cellulose (MCC) capsules daily. The serum concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were determined.

Result

The serum levels of TNF-α, IL-6, and hs-CRP significantly declined in the NS group (p < 0.001), CUR (p < 0.001, p < 0.001, p = 0.001, respectively), and NS-CUR (p < 0.001) groups compared to baseline. Between-group analyses revealed that IL-6 and TNF-α showed significant reductions in the NS, CUR, and NS-CUR groups (p < 0.001) compared to placebo. Despite significant reductions in hs-CRP in the NS and NS-CUR groups (p = 0.001, p < 0.001, respectively), no significant differences were identified between the CUR and placebo groups (p = 0.096).

Conclusion

The supplementation of CUR, NS, and NS-CUR modulated IL-6, TNF-α, and hs-CRP levels. Moreover, the co-supplementation of NS and CUR significantly influenced inflammatory biomarkers.

持续的炎症，无论是由激素变化直接介导的还是由氧化应激诱导的，都对骨骼健康有显著的负面影响，可能导致绝经后骨质减少和骨质疏松症的发生。抗炎草药产品，以成本效益和安全性而闻名，支持骨骼重塑。本研究评估姜黄素纳米胶束（CUR）、黑草（NS）及其共补充物（NS-CUR）对绝经后骨质疏松或骨质疏松妇女血清炎症因子的影响。方法对120例绝经后妇女进行三盲随机对照试验。根据骨密度将患者分为四组。在6个月的干预期间，NS组每天服用NS油胶囊和CUR安慰剂胶囊。CUR组每天服用一个CUR胶囊和一个NS安慰剂胶囊。NS-CUR组每日给予1颗CUR胶囊和1颗NS油胶囊。安慰剂组每天服用两粒微晶纤维素（MCC）胶囊。测定血清中高敏c反应蛋白（hs-CRP）、白细胞介素-6 （IL-6）、肿瘤坏死因子-α (TNF-α)的浓度。ResultThe血清TNF -α、il - 6和hs-CRP NS组显著下降(p & lt; 0.001),坏蛋(p & lt; 0.001,p & lt; 0.001,p = 0.001,分别),和NS-CUR (p & lt; 0.001)组与基线相比。组间分析显示，与安慰剂组相比，NS组、CUR组和NS-CUR组IL-6和TNF-α显著降低（p <； 0.001）。尽管NS组和NS-CUR组hs-CRP显著降低（p = 0.001,p <； 0.001），但在CUR组和安慰剂组之间没有发现显著差异（p = 0.096）。结论补充CUR、NS和NS-CUR可调节IL-6、TNF-α和hs-CRP水平。此外，NS和CUR的共同补充显著影响炎症生物标志物。

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引用次数: 0

Promoting emotional resilience through laughter yoga in health professions education 在卫生专业教育中通过笑瑜伽促进情绪恢复

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-06-18 DOI: 10.1016/j.aimed.2025.100527

Manuel Millán-Hernández , Daniela F. Albarrán-Pérez

引用次数: 0

Ending the exploitation of wild animals in traditional medicine: An urgent call for global conservation action 终止在传统医学中利用野生动物：紧急呼吁采取全球保护行动

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-05-30 DOI: 10.1016/j.aimed.2025.100525

Emad M. Abdallah

引用次数: 0

A new paradigmatic framework for integrative medicine, and its implications for medicine and politics 结合医学的新范式框架及其对医学和政治的影响

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-05-28 DOI: 10.1016/j.aimed.2025.100526

Josef M. Schmidt

Introduction

One of the major shortcomings of the discussion concerning integrative medicine is often an insufficient awareness of the peculiarity and multi-dimensionality of the object in question, on the part of critics and advocates alike.

Methods

Focusing on homeopathy as an example, this paper points out that the essence of this unique concept of healing cannot be wholly understood without a basic knowledge of the dimensions that constitute it.

Results

The three traditions of thinking on which it is based date back to antiquity, namely: lógos-thinking, hómoion-thinking and iásthai-thinking, i.e. thinking in terms of rationality, similarity and healing.

Discussion

While modern medicine is, for the most part, driven by reasoning in terms of quantification and generalisation, this at the cost of neglecting the remaining two dimensions, – homeopathy, due to its methodology, finds itself constantly searching to find a balance for all of its constituents.

Conclusions

This model of a three-dimensional art of healing may serve as a paradigm for integrative medicine to recollect an awareness of its own strength and multi-dimensionality, and, finally, also for medicine and politics in general.

关于中西医结合的讨论的一个主要缺点是，批评者和倡导者对所讨论对象的特殊性和多维性往往认识不足。方法本文以顺势疗法为例，指出如果不了解其构成维度的基本知识，就不能完全理解这种独特治疗概念的本质。结果它所依据的三种思维传统可以追溯到古代，即：lógos-thinking、hómoion-thinking和iásthai-thinking，即理性思维、相似性思维和治愈思维。虽然现代医学在很大程度上是由量化和概括的推理所驱动的，但这是以忽视剩余的两个维度为代价的，——顺势疗法，由于其方法论，发现自己不断地寻找所有成分的平衡。这个三维治疗艺术的模型可以作为一个范例，让整合医学重新认识到其自身的力量和多维度，最后，也可以作为医学和政治的一般范例。

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引用次数: 0

An altmetric analysis of the research literature about traditional, complementary, and integrative medicine 对传统医学、补充医学和综合医学研究文献的替代分析

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-05-23 DOI: 10.1016/j.aimed.2025.100506

Jeremy Y. Ng , Alep Judge , Holger Cramer

Background

The use of traditional, complementary, and integrative medicine (TCIM) is known to be popular worldwide; there have been over 200,000 research articles published on this topic as of 2024. For decades, traditional citation-based metrics have been the assumed norm when assessing the impact of research, but in the digital age, alternative metrics (altmetrics) have also become a valuable proxy. By analyzing trends associated with the altmetrics of scholarly outputs relating to TCIM, patterns of social engagement were identified to obtain a better understanding of the factors that drive social impact in this field online.

Methods

This study was conducted using Altmetric.com, whereby this database was searched by the subject area “Traditional, Complementary and Integrative Medicine”. The subsequent data obtained was further analyzed to discern social trends within TCIM scholarly outputs at the article level.

Results

62,278 research outputs, from 1925 to 2024, with +497,000 online mentions were analyzed. Outputs from the Journal of Natural Products were mentioned the most frequently online (n = 5314, 10.56 %). The highest average Altmetric attention scores were associated with news outputs (M = 203.67), and outputs published under a bronze OA type (M = 17.54). The most mentions were contributed by X (n = 350,630, 70.41 %), Facebook (n = 57,540, 11.55 %), and news outlets (n = 39,941, 8.02 %).

Conclusions

Using the features found in this study to be linked with higher online attention, and sharing research through well-used online platforms, may help make TCIM research more visible to the public and more relevant to policy discussions.

传统、补充和综合医学（TCIM）的使用在全世界都很流行；截至2024年，已经有超过20万篇关于这一主题的研究论文发表。几十年来，传统的基于引用的指标一直是评估研究影响的假设标准，但在数字时代，替代指标（altmetrics）也已成为一种有价值的替代指标。通过分析与TCIM相关的学术产出替代指标相关的趋势，确定了社会参与模式，以便更好地了解在线推动该领域社会影响的因素。方法本研究使用Altmetric.com进行，该数据库按主题领域“传统、补充和综合医学”进行检索。随后获得的数据被进一步分析，以在文章水平上辨别TCIM学术产出的社会趋势。结果共收录1925 - 2024年62278篇论文，其中网络提及次数497000次。《自然产物杂志》（Journal of Natural Products）的产出在网上被提及的频率最高（n = 5314,10.56 %）。最高的Altmetric平均注意力得分与新闻产出（M = 203.67）和青铜OA类型下发表的产出（M = 17.54）相关。提到大多数是由X (70.41 n = 350630年  %),Facebook (11.55 n = 57540年  %),和新闻媒体(8.02 n = 39941年  %)。利用本研究中发现的特征与更高的在线关注相关联，并通过使用良好的在线平台分享研究，可能有助于使TCIM研究更容易被公众看到，并与政策讨论更相关。

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引用次数: 0

The effects of the pregnant woman’s mental visualization of her baby during the non-stress test on maternal anxiety and fetal parameters: A randomized controlled clinical trial 非压力测试中孕妇对婴儿的心理可视化对母亲焦虑和胎儿参数的影响：一项随机对照临床试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-05-23 DOI: 10.1016/j.aimed.2025.100508

Fatma Keskin Töre , Cansu Ağralı , Gülçin Nacar , Özlem Özel Özcan

Objective

The aim of this study is to examine the effects of pregnant women’s mental visualization of their babies during the non-stress test on maternal anxiety and fetal parameters.

Methods

This randomized controlled clinical trial was completed with 64 pregnant women (32 experimental, 32 control). It was conducted in a public hospital located in eastern Turkey. Data were collected using a personal information form, a non-stress test findings form, a baby picture evaluation form, and the State Anxiety Inventory.

Results

It was determined that during NST (Non-Stress Test), pregnant women’s visualization of their babies reduced the fetal heart rate (t = 2.083, p = 0.041) and fetal movements (t = 2.110, p = 0.039) while increasing the number of accelerations (t = 4.845, p = 0.001). There was no significant difference between the maternal anxiety levels in the experimental group and those in the control group (t = 1.184, p = 0.241). The maternal anxiety levels of the participants in the experimental increased in the posttest compared to the pretest (t = 3.371, p = 0.002).

Conclusion

It was determined that the pregnant woman’s mental visualization of her baby during the non-stress test reduced the fetal heart rate and fetal movements, increased the number of accelerations, and did not significantly affect maternal anxiety.

目的探讨孕妇在非应激测试中对婴儿的心理可视化对母亲焦虑和胎儿参数的影响。方法随机对照临床试验64例孕妇，其中试验组32例，对照组32例。这是在土耳其东部的一家公立医院进行的。数据通过个人信息表、非压力测试结果表、婴儿照片评估表和状态焦虑量表收集。淬硬决心,在望远镜(那样正常学习测试),孕妇的可视化婴儿减少了胎儿心率(t = 2.083,p = 0.041)和胎儿运动(t = 2.110,p = 0.039)的数量,同时增加加速度(t = 4.845,p = 0.001)。实验组与对照组产妇焦虑水平差异无统计学意义（t = 1.184,p = 0.241）。实验参与者的母亲焦虑水平在测试后较测试前有所增加（t = 3.371,p = 0.002）。结论在非应激试验中，孕妇对胎儿的心理可视化降低了胎儿心率和胎动，增加了加速次数，对产妇焦虑无显著影响。

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引用次数: 0

Effects of scalp acupuncture treatment on motor dysfunction in children with spastic cerebral palsy: A multicenter randomized controlled trial 头皮针刺治疗痉挛型脑瘫患儿运动功能障碍的疗效：一项多中心随机对照试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-05-21 DOI: 10.1016/j.aimed.2025.100505

Jun Wang , Xueyan Li , Wei Shi , Bingpei Shi , Xiaojuan Shi , Dandan Luo , Xiushu Shen , Chun Zhai , Lei Xu , Meirong Li , Nan Su , Rencai Deng , Huayu Huang , Jian Li , Yin Wang , Hong Yang

Introduction

Scalp acupuncture has been widely used as a treatment for motor dysfunction in children with cerebral palsy (CP). Previous studies have not provided high-quality evidence to demonstrate the effectiveness of this treatment in children with CP. To date, no high-quality randomized controlled trials on scalp acupuncture have been reported. The present study aims to evaluate the effectiveness of Jiao's scalp acupuncture for the treatment of motor dysfunction in children with spastic CP.

Methods

This was a randomized controlled trial. One hundred CP patients were randomly allocated to either the treatment or control group. The control group received conventional rehabilitation treatment, while the treatment group received both conventional rehabilitation treatment and Jiao’s scalp acupuncture. Thirty-six treatment sessions were conducted over a 12-week period. Outcomes were assessed using the Gross Motor Function Measure (GMFM)-66 and the Fine Motor Function Measure (FMFM) at baseline, week 4, 8, 12 (post-treatment) and week 24 (follow-up).

Results

Both groups showed significant improvements in motor function (p < 0.01), as assessed by the GMFM-66 and the FMFM. Compared to the control, the treatment group demonstrated a significantly greater improvement in both gross and fine motor function (p < 0.05).

Conclusions

Acupuncture in the motor area of Jiao's scalp acupuncture significantly improved motor function in children with spastic CP. Scalp acupuncture treatment may serve as a beneficial adjunct to conventional rehabilitation for motor dysfunction in this population.

Trial registration

ClinicalTrials.gov, NCT03921281.

头皮针刺已被广泛用于治疗脑瘫（CP）患儿的运动功能障碍。以前的研究没有提供高质量的证据来证明这种治疗对CP儿童的有效性。迄今为止，尚无关于头皮针灸的高质量随机对照试验的报道。本研究旨在评价焦氏头皮针治疗小儿痉挛性脑瘫运动障碍的疗效。方法采用随机对照试验。100名CP患者被随机分配到治疗组和对照组。对照组接受常规康复治疗，治疗组在常规康复治疗的基础上同时进行焦氏头皮针刺治疗。在12周的时间内进行了36次治疗。在基线、第4周、第8周、第12周（治疗后）和第24周（随访）时，使用大运动功能量表(GMFM)-66和精细运动功能量表（FMFM）评估结果。结果通过GMFM-66和FMFM评估，两组患者的运动功能均有显著改善（p <； 0.01）。与对照组相比，治疗组在粗大和精细运动功能方面均表现出更大的改善（p <； 0.05）。结论头皮针运动区针刺可显著改善痉挛性脑瘫患儿的运动功能，头皮针治疗可作为该人群运动功能障碍常规康复的有益辅助。临床试验注册：clinicaltrials .gov, NCT03921281。

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引用次数: 0

Aromatherapy as an antimicrobial intervention: Anecdotal promise or evidence-based therapy? A call for rigorous scientific evaluation 芳香疗法作为一种抗菌干预：道听途说还是循证疗法？呼吁进行严格的科学评估

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-05-20 DOI: 10.1016/j.aimed.2025.100507

Emad M. Abdallah

引用次数: 0

Effects of various hydrotherapeutic procedures on heart rate variability and blood pressure: A systematic review 各种水疗法对心率变异性和血压的影响：一项系统综述

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-05-16 DOI: 10.1016/j.aimed.2025.100500

S. Abinaya , A. Vijay , L. Nivethitha , A. Mooventhan , N. Manavalan

Background

The autonomic nervous system (ANS) regulates involuntary physiological processes including blood pressure. Hydrotherapy uses water to treat various conditions and research on effect of different hydrotherapy modalities at varying temperatures on the heart rate variability (HRV) is increasing for the past few years. However, there is no systematic review of on it. Hence, this systematic review was performed to provide evidence-based effects of hydrotherapy on HRV.

Materials and methods

We have searched PubMed/Medline and google scholar electronic databases to find relevant articles using following keywords: hydrotherapy, balneotherapy, cryotherapy, sauna bath, immersion bath, foot bath, spinal bath, hip bath, arm and foot bath, ice massage and heart rate variability. Out of 121 articles found, 24 potentially eligible articles were reported in this review.

Results

In this systematic review 24 articles (including 6 RCTs) with 961 participants with various condition, underwent various hydrotherapy modalities with different temperatures were reported. The finding showed that majority of the hydrotherapy modalities produces improvements in parasympathetic activity and regulation of autonomic nervous system. However, only one study showed increased sympathetic activity during the session and transitioned into parasympathetic activity after 15–120 min of session.

Conclusion

Literature suggests that hydrotherapy is effective in reducing blood pressure and improving HRV as an adjuvant in healthy volunteers, sportspeople, and in patients with hypertension, heart failure, migraines, allergic rhinitis, and chronic fatigue syndrome. However, the quality of the studies included in this review low. Hence, we recommend high quality long-term RCTs to determine the efficacy and safety of hydrotherapy.

自主神经系统（ANS）调节包括血压在内的不自主生理过程。水疗法利用水来治疗各种疾病，在过去的几年里，关于不同温度下不同水疗法对心率变异性（HRV）影响的研究越来越多。然而，目前还没有对其进行系统的评价。因此，本系统综述旨在提供基于证据的水疗法对HRV的影响。材料与方法我们检索PubMed/Medline和谷歌学者电子数据库，使用以下关键词检索相关文章：水疗法，浴疗，冷冻疗法，桑拿浴，浸泡浴，足浴，脊柱浴，髋关节浴，手臂和足浴，冰按摩和心率变异性。在121篇文章中，本综述报告了24篇潜在符合条件的文章。结果本系统综述共纳入24篇文献（包括6篇随机对照试验），961名不同病情、不同温度、不同水疗方式的受试者。研究结果表明，大多数水疗方式可改善副交感神经活动和自主神经系统的调节。然而，只有一项研究显示，在会话期间交感神经活动增加，并在会话15-120 分钟后过渡到副交感神经活动。结论文献表明，在健康志愿者、运动员、高血压、心力衰竭、偏头痛、变应性鼻炎和慢性疲劳综合征患者中，水疗法作为辅助疗法可有效降低血压和改善HRV。然而，本综述纳入的研究质量较低。因此，我们推荐高质量的长期随机对照试验来确定水疗法的疗效和安全性。

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引用次数: 0